1. Signaling Pathways
  2. JAK/STAT Signaling
    Stem Cell/Wnt
  3. STAT

STAT

STAT

STAT is a family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The transcription factors of this family are activated by Janus kinase and dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression. Gene knockout studies have provided evidence that STAT proteins are involved in the development and function of the immune system and play a role in maintaining immune tolerance and tumour surveillance. STAT proteins were originally described as latent cytoplasmic transcription factors that require phosphorylation for nuclear retention. The unphosphorylated STAT proteins shuttle between cytosol and the nucleus waiting for its activation signal. Once the activated transcription factor reaches the nucleus, it binds to consensus DNA-recognition motif called gamma-activated sites (GAS) in the promoter region of cytokine-inducible genes and activates transcription of these genes.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2959R
    Brevilin A (Standard)
    Inhibitor
    Brevilin A (Standard) is the analytical standard of Brevilin A. This product is intended for research and analytical applications. Brevilin A is an orally active STAT3/JAK inhibitor (STAT3 IC50= 10.6 μM). Brevilin A shows anti-tumor activity, anti-proliferative activity to cancer cells, and can induce apoptosis and autophagy.
    Brevilin A (Standard)
  • HY-169182
    AK-068
    AK-068 is a STAT6 ligand, with a Ki of 6 nM and at least >85-fold binding selectivity over STAT5. AK-068 is a ligand for target protein (STAT6) for PROTAC (HY-169179).
    AK-068
  • HY-N13294
    Cernuumolide J
    Inhibitor
    Cernuumolide J (TMJ-105) is an JAK2/STAT3 inhibitor. Cernuumolide J induces G2/M phase arrest and apoptosis in HEL leukemia cells by downregulating the phosphorylation of JAK2, STAT3, and Erk, and activating the phosphorylation of JNK and p38 MAPK. Cernuumolide J inhibits HEL leukemia cell growth in a time- and concentration-dependent manner, with an IC50 value of 1.79 μM. Cernuumolide J can be used for research in the field of anti-cancer therapy.
    Cernuumolide J
  • HY-N0202R
    Atractylenolide II (Standard)
    Inhibitor
    Atractylenolide II (Standard) is the analytical standard of Atractylenolide II. This product is intended for research and analytical applications. Atractylenolide II (Asterolide) is a sesquiterpenoid compound. Atractylenolide II can induce G1 phase cell cycle arrest and apoptosis in B16 melanoma cells. Atractylenolide II is an orally effective anticancer agent that can exert anti-melanoma effects by inhibiting the STAT3 signaling pathway. In addition, Atractylenolide II has been shown to ameliorate myocardial fibrosis, oxidative stress, and neuroprotective activity.
    Atractylenolide II (Standard)
  • HY-172767
    STAT3-D11-PROTAC-VHL
    Degrader
    STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting Signal Transducer and Activator of Transcription 3 (STAT3). STAT3-D11-PROTAC-VHL exhibits anti-tumor activity with IC50 values of 1335 nM and 1973 nM against HeLa and MCF-7 cells, respectively. STAT3-D11-PROTAC-VHL binds to the DNA-binding domain of STAT3 and recruits the E3 ligase VHL to form a ternary complex, leading to the ubiquitination of STAT3 and subsequent degradation by the proteasome. STAT3-D11-PROTAC-VHL also inhibits tumor cell growth, induces cell cycle arrest and apoptosis, and suppresses tumor immune evasion.
    STAT3-D11-PROTAC-VHL
  • HY-151559
    Zn-DPA-maytansinoid conjugate 1
    Modulator
    Zn-DPA-maytansinoid conjugate 1 is a small molecule-based maytansinoid conjugate targeting immune checkpoint. Zn-DPA-maytansinoid conjugate 1 induces lasting regression of tumor growth and rejuvenates tumor microenvironment (TME) to an "inflamed hot tumor" .
    Zn-DPA-maytansinoid conjugate 1
  • HY-151286
    Antitumor agent-73
    Inhibitor
    Antitumor agent-73 is a Diosgenin (HY-N0177) derivative, which inhibits STAT3 signaling and activates Pdia3/ERp57 exogenously. Antitumor agent-73 shows potent anti-tumor activity against various cancer cell lines, 7.9-341.7-fold stronger than Diosgenin.
    Antitumor agent-73
  • HY-N0751R
    Scutellarin (Standard)
    Inhibitor
    Scutellarin (Standard) is the analytical standard of Scutellarin. This product is intended for research and analytical applications. Scutellarin, an active flavone isolated from Scutellaria baicalensis, can down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts. Scutellarin is active against HIV-1IIIB, HIV-1(74V) and HIV-1KM018 with EC50s of 26 μM, 253 μM and 136 μM, respectively.
    Scutellarin (Standard)
  • HY-N6954R
    Garcinone C (Standard)
    Inhibitor
    Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active.
    Garcinone C (Standard)
  • HY-119487
    MMPP
    Inhibitor
    MMPP is an anti-inflammatory agent. MMPP prevents LPS-induced mortality by inhibiting the inflammatory response via STAT3 activity inhibition.
    MMPP
  • HY-159570
    XD2-149
    XD2-149 is a PROTAC targeting STAT3. XD2-149 consists of PROTAC target protein ligand Napabucasin (HY-13919) (red part), E3 ligase Thalidomide (HY-14658) (black part), and linker NH2-C5-Azacyclohexane-N-Boc (HY-159572) (blue part). The E3 ligase + linker conjugate is Thalidomide-NH-C5-azacyclohexane-N-Boc (HY-159571), and the active control of the target protein ligand is Thalidomide acid (HY-159573)[1].
    XD2-149
  • HY-RS13897
    Stat6 Mouse Pre-designed siRNA Set A
    Inhibitor

    Stat6 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stat6 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Stat6 Mouse Pre-designed siRNA Set A
    Stat6 Mouse Pre-designed siRNA Set A
  • HY-169180
    AK-068-OH
    AK-068-OH (Compound 49) is an active control of ligand for target protein for PROTAC (HY-169179).
    AK-068-OH
  • HY-112447
    STAT3-IN-5
    Inhibitor
    STAT3-IN-5 is a potent STAT3 inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC50 value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer.
    STAT3-IN-5
  • HY-168893
    K882
    Inhibitor
    K882 (Compound 4e) is a Src inhibitor, with KD of 0.315 μM. K882 induces Apoptosis. K882 inhibits XIAP and Survivin. K882 inhibits the activation of PI3K/Akt/mTOR, Jak1/Stat3, Ras/MAPK signaling pathways. K882 shows anti-tumor activity against non-small cell lung cancer.
    K882
  • HY-164445
    STAT3-IN-32
    Inhibitor
    STAT3-IN-32 (compound 2p) is an orally active, potent STAT3 dual phosphorylation inhibitor with an indole-containing tetra-aromatic heterocycle scaffold. STAT3-IN-32 exhibits STAT3 luciferase inhibition activity using HEK293T cells with an IC50 of 5.3 nM and ATP production inhibition activity using BxPC-3 cells with an IC50 of 4.2 nM. STAT3-IN-32 significantly blocks p-Tyr705 and p-Ser727 and causes the abrogation of the corresponding nuclear transcription and mitochondrial oxidative phosphorylation functions of STAT3 by targeting the STAT3 SH2 domain (KD=21.3 nM). STAT3-IN-32 exhibits significant suppressive effects in a pancreatic cancer xenograft model.
    STAT3-IN-32
  • HY-173236
    STAT4-IN-1
    Inhibitor
    STAT4-IN-1 is an inhibitor of STAT4 with a Ki of 0.35 μM. STAT4-IN-1 is expected to be used in the research of autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and diabetes.
    STAT4-IN-1
  • HY-D145729F
    FAM-Danvatirsen
    Inhibitor
    FAM-Danvatirsen is a FAM-labeled Danvatirsen (HY-145729). Danvatirsen is an antisense oligonucleotide targeting STAT3 that can be used in the study of cancer.
    FAM-Danvatirsen
  • HY-169242
    JAK1-IN-16
    Inhibitor
    JAK1-IN-16 (compound 4l) is an inhibitor of JAK1/STAT3 and effectively downregulates TLR4 protein expression..
    JAK1-IN-16
  • HY-162405
    Smad2/3-IN-1
    Inhibitor
    Smad2/3-IN-2 (Compound 27) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC50s of 90 and 20 nM, respectively.
    Smad2/3-IN-1
Cat. No. Product Name / Synonyms Application Reactivity

STAT3

STAT5

STAT6

STAT1

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

STAT Degraders, Inducers, Inhibitors & Activators
Product NameSTAT3STAT5STAT6STAT1Purity    
Stattic
STAT3
   99.58%
AG490
Stat-3
   99.86%
Cilengitide
STAT3 ([3])
   99.80%
Homoharringtonine
STAT3
   99.96%
Ac-GpYLPQTV-NH2 acetate
STAT3, IC50: 0.33 μM
   99.38%
AS1517499  
STAT6, IC50: 21 nM
 99.17%
Niclosamide
STAT3, IC50: 0.25 μM (in HeLa cells)
   99.91%
Artesunate
Stat-3
   99.89%
C188-9
STAT3, Kd: 4.7 nM
   99.90%
GYY4137
Stat-3
   98.08%
NSC 74859
STAT3, IC50: 86 μM
   98.35%
Colivelin
STAT3
   99.27%
Butyzamide
STAT3
STAT5
  99.62%
Astaxanthin
STAT3
   ≥98.0%
TPCA-1
STAT3
   99.66%
WP1066
STAT3
   99.77%
Scutellarin
STAT3
   99.04%
Napabucasin
STAT3
   99.94%
Cryptotanshinone
STAT3, IC50: 4.6 μM
   98.80%
STAT5-IN-1 
STAT5β, IC50: 47 μM
  98.35%
Pimozide
STAT3
STAT5
  99.91%
Colivelin TFA
STAT3
   99.52%
SD-36
STAT3, Kd: 50 nM
   99.73%
Diosgenin
STAT3
   99.35%
Saikosaponin D
STAT3
   98.76%
AC-4-130 
STAT5
  99.93%
Cucurbitacin I
STAT3
   99.44%
SH-4-54
STAT3, Kd: 300 nM
STAT5, Kd: 464 nM
  99.80%
Morusin
STAT3
   99.94%
SI-109
STAT3, Ki: 9 nM
   99.91%
AS2863619 
STAT5
  99.94%
BP-1-102
STAT3, IC50: 6.8 μM
   99.52%
Alantolactone
STAT3
   99.94%
SC-43
p-STAT3
   99.01%
Nifuroxazide
STAT3
   99.90%
AK-2292 
STAT5, DC50: 0.10 μM
  99.73%
YM-341619  
STAT6, IC50: 0.70 nM
 98.01%
AS1810722  
STAT6, IC50: 1.9 nM
 98.14%
Erasin
STAT3, IC50: 9.7 μM
  
STAT1, IC50: 24 μM
STAT3-IN-1
Stat-3, IC50: 1.82 μM (in HT29 cells)
Stat-3, IC50: 2.14 μM (in MDA-MB 231 cells)
   
NSC-370284
STAT3
STAT5
  
Brevilin A
STAT3, IC50: 10.6 μM
   99.86%
1-Stearoyl-sn-glycero-3-phosphocholine
p-STAT3
   99.53%
Peramivir
STAT3
   99.32%
Atractylenolide II
p-STAT3
   99.94%
Stafia-1 
STAT5a, Ki: 10.9 μM
STAT5a, IC50: 22.2 μM
  99.37%
STAT3-IN-3
STAT3
   98.40%
Broussonin E
STAT3
   98.18%
AK-1690  
STAT6, DC50: 1 nM
 99.91%
Flubendazole
STAT3
   99.33%
STAT6-IN-4  
STAT6, IC50: 0.34 μM
 99.75%
HO-3867
STAT3
   99.67%
Radotinib
STAT3
   98.92%
HJC0152
STAT3
   99.76%
BD750 
STAT5
  99.10%
STX-0119
STAT3, IC50: 74 μM (STAT3 transcription)
   99.21%
Perindopril erbumine
STAT3
   99.98%
Picroside I  
STAT6
 99.55%
LLL12
p-STAT3
   99.45%
GMB-475 
STAT5
  98.69%
Serplulimab
p-STAT3
   99.30%
Stafib-1 
STAT5b, IC50: 154 nM
  ≥98.0%
Cenisertib 
STAT5
  99.86%
STAT3-IN-25
STAT3
   99.36%
Garcinone D
p-STAT3
   99.88%
Ginkgolic acid C17:1
STAT3
   99.90%
KT-333
STAT3
   
OSM-SMI-10B
p-STAT3
   99.28%
Mogrol
STAT3
   99.76%
IST5-002 
STAT5a, IC50: 1.5 μM
STAT5b, IC50: 3.5 μM
  99.36%
STAT6-IN-5  
STAT6, IC50: 0.24 μM
 99.88%
inS3-54A18
STAT3
   99.53%
Triacetylresveratrol
STAT3
   99.58%
Corylifol A
STAT3, IC50: 0.81 μM
   99.90%
Desmethoxyyangonin
STAT3
   99.47%
Perindopril
STAT3
   98.11%
Garcinone C
Stat-3
   99.66%
Olokizumab
Stat-3
   
STAT5-IN-2 
STAT5, EC50: 9 μM (in K562 cells)
STAT5, EC50: 5 μM (in KU812 cells )
  99.08%
Ochromycinone
STAT3
   98.29%
STAT3-IN-12
STAT3
   99.92%
Reticuline
STAT3
   98.91%
Golotimod hydrochloride
STAT3
   99.79%
Protosappanin A
STAT3
   99.98%
YMU1
STAT3
   99.19%
Tetramethylcurcumin
STAT3
   99.91%
HODHBt 
STAT5
  99.93%
LL-K8-22   
STAT1
99.76%
Balsalazide
STAT3
   99.34%
HJC0416 hydrochloride
STAT3
   98.68%
STAT3-IN-15
STAT3
   98.99%
ASP3026
STAT3
   99.88%
AS2863619 free base 
STAT5
  99.87%
STAT3-IN-17
STAT3
   ≥98.0%
OK2
p-STAT3
   
SC99
STAT3
   98.96%
Golotimod
STAT3
   98.04%
SB02024   
STAT1
99.70%
PROTAC FLT-3 degrader 1 
STAT5
  99.74%
Equisetin
STAT3
   99.40%
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea
p-STAT3
   98.02%
Balsalazide sodium hydrate
STAT3
   99.61%
WB436B
STAT3
   99.93%
MNK8
STAT3
   99.76%
Vanicoside B
STAT3
   99.82%
APTSTAT3-9R
STAT3
   
ENMD-1198
STAT3
   98.87%
UC-514321
STAT3
STAT5
  ≥98.0%
SH5-07
STAT3, IC50: 3.9 μM
   ≥98.0%
Syk-IN-6
STAT3
STAT5
  
SD-1029
STAT3
   
Iminostilbene
STAT3
   99.34%
Eflepedocokin alfa
STAT3
   ≥99.0%
Pimozide-d4
STAT3
STAT5
  ≥98.0%
Galiellalactone
STAT3, IC50: 250-500 nM
   
Biflorin   
STAT1
99.54%
Stafia-1-dipivaloyloxymethyl ester 
STAT5a
  98.31%
Eupalinolide K
STAT3
   99.20%
Niclosamide monohydrate
STAT3, IC50: 0.25 μM (in HeLa cells)
   
SD-1008
STAT3
   99.10%
STAT3-IN-8
STAT3
   
KT-333 diammonium
STAT3
   
YSY01A
Stat-3
   
c-Met-IN-24
STAT3, IC50: 4.7 μM
   
STAT3-IN-37
STAT3
   
STAT3 HiBiT degrader 1
STAT3
   
STAT3-IN-38
STAT3, Kd: 45.33 μM
   
STAT3-IN-29
STAT3
   
VEGFR-2/STAT-3-IN-1
STAT3, IC50: 5.63 nM
   
8α-Tigloyloxyhirsutinolide 13-O-acetate
STAT3
   
STAT1/3-IN-1
STAT3
  
STAT1
KT-333 ammonium
STAT3
   
WR-S-462
STAT3, Kd: 58 nM
   
JAK1/STAT3-IN-1
STAT3
   
FLT3-IN-28 
STAT5
  
SD-436
STAT3, IC50: 19 nM
STAT5, IC50: >10 μM
STAT6, IC50: >10 μM
STAT1, IC50: 270 nM
STAT3/AKT-IN-1
Stat-3
   
ROCK2-IN-7
Stat-3
   
Anti-inflammatory agent 92
STAT3
   
STAT3-IN-41
STAT3
   
Golotimod TFA
STAT3
   
HJC0416
STAT3
   
HJC0123
STAT3
   
HAT-SIL-TG-1&AT
STAT3
STAT5
  
7-epi-Isogarcinol
STAT3
   
AK-068  
STAT6
 
Cernuumolide J
Stat-3
   
Atractylenolide II (Standard)
p-STAT3
   
STAT3-D11-PROTAC-VHL
STAT3
   
Antitumor agent-73
STAT3
   
STAT3-IN-5
p-STAT3, EC50: 170 nM
   
K882
Stat-3
   
STAT3-IN-32
STAT3
   
WB518
STAT3
p-STAT3
   
Hsp110-STAT3 interaction-IN-2
STAT3
   
Ac-GpYLPQTV-NH2
STAT3, IC50: 0.33 μM
   
STAT3-IN-9
STAT3
   
PROTAC STAT3 degrader-2
STAT3, ID50: 3.54 μM
   
Ascochlorin
STAT3
   
Tyk2-IN-22-d3 
STAT5
  
1-Stearoyl-sn-glycero-3-phosphocholine-d35
p-STAT3
   
NW16
STAT3, Kd: 11.0 μM
   
15(R)-Lipoxin A4  
STAT6
 
Furowanin A
STAT3
   
Antitumor agent-195
STAT3, IC50: 0.52 μM
   
STAT3-IN-10
STAT3, IC50: 5.18 μM
   
Balsalazide disodium
STAT3
   
GYY4137 (GMP)
Stat-3
   
CHMFL-48 
STAT5
  
DETD-35
Stat-3
   
STAT3-IN-39
STAT3
   
TM-233
Stat-3
   
BP-1-108 
STAT5, Ki: 8.3 μM
  
PMMB-187
Stat-3, IC50: 1.81 μM