STAT

STAT Isoform Specific Products:

STAT Isoform Comparison

STAT Related Products (418)
Antibodies (25)
STAT Isoform Comparison

By Effects:	Controls (2) Inhibitors (339) Agonists (3) Degraders (9) Antagonist (1) Activators (23) Modulators (4)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-169242

JAK1-IN-16	Inhibitor
JAK1-IN-16 (compound 4l) is an inhibitor of JAK1/STAT3 and effectively downregulates TLR4 protein expression..

HY-162405

Smad2/3-IN-1	Inhibitor
Smad2/3-IN-2 (Compound 27) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC₅₀s of 90 and 20 nM, respectively.

HY-163176

WB518	Inhibitor
WB518 is a potent STAT3 inhibitor. WB518 effectively inhibits STAT3 activation and Keratin 17 expression. WB518 effectively alleviates imiquimod (HY-B0180) and TPA (HY-18739)-induced animal psoriasis by inhibiting STAT3 phosphorylation and Keratin 17.

HY-168178

Hsp110-STAT3 interaction-IN-2	Inhibitor
Hsp110-STAT3 interaction-IN-2 (compound 10b) is a Hsp110-STAT3 interaction disruptor. Hsp110-STAT3 interaction-IN-2 can be used in pulmonary arterial hypertension (PAH) related research.

HY-164349

WZ-2-033	Inhibitor
WZ-2-033 is a potent STAT3 inhibitor. WZ-2-033 inhibits MDA-MB-231, HCC70, and MDA-MB231-4175 cells proliferation, colony survival, migration, and invasion with IC₅₀s of 0.7, 1.3, and 1.3 μM, respectively.

HY-172201

NF-κB-IN-19	Inhibitor
NF-κB-IN-19 (Compound 8) is an NF-κB inhibitor. NF-κB-IN-19 effectively induces DNA damage, promotes the generation of ROS, and induces autophagy and apoptosis through the NF-κB signaling pathway in tumor cells. In addition, NF-κB-IN-19 can inhibit the levels of VEGF and HIF-1α, and exert antiproliferative activity in tumor cells through the PI3K/AKT and STAT-3 pathways. NF-κB-IN-19 can effectively overcome cisplatin resistance and has anti-tumor activity.

HY-150251

STAT3 degrader-2	Degrader
STAT3 degrader-2 is a PROTAC-based degrader of STAT3. STAT3 degrader-2 can degrade the level of total STAT3 protein. STAT3 degrader-2 can be used for the research of cancer and other diseases. STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-162607

STAT3-IN-28	Inhibitor
STAT3-IN-28 (compound 18) is a STAT3 inhibitor. STAT3-IN-28 can inhibit the activation of microglia and has anti-neuroinflammatory effects. STAT3-IN-28 can cross the blood-brain barrier.

HY-169361

STAT3 ligand 5
STAT3 ligand 5 is a ligand for STAT3, that can be used as target protein ligand for synthesis of PROTAC degrader SD-436 (HY-169360).

HY-119347R

Cirsilineol (Standard)	Inhibitor
Cirsilineol (Standard) is the analytical standard of Cirsilineol. This product is intended for research and analytical applications. Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice.

HY-161136

EGFR/STAT3-IN-1	Inhibitor
EGFR/STAT3-IN-1 (Compound 5k) is a dual inhibitor of EGFR/STAT3 with IC₅₀ values for EGFR and STAT3 are 41 and 3.34 nM, respectively. EGFR/STAT3-IN-1 has antitumor activity.

HY-169007

STAT3-IN-34	Inhibitor
STAT3-IN-34 (Compound 15E) is an inhibitor for STAT3, and inhibits the nuclear translocation and transcriptional regulator activity of STAT3. STAT3-IN-34 inhibits the proliferation of cell HaCaT with IC₅₀ of 0.008 μM. STAT3-IN-34 inhibits IL-17A expression and ameliorates Imiquimod (HY-B0180)-induced psoriasis in mice.

HY-P10201

Ac-GpYLPQTV-NH2	Inhibitor
Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC₅₀ value of 0.33 μM. Ac-GpYLPQTV-NH2 has antitumor activity.

HY-159580

STAT3-IN-31	Inhibitor
STAT3-IN-31 (compound K2071) is a STATtic-derived STAT3 and mitotic inhibitor. STAT3-IN-31 blocks mitotic progression and affects the formation of mitotic spindles. STAT3-IN-31 also affects glioblastoma cell migration and inhibits cell proliferation in tumor spheroids. STAT3-IN-31 is also able to induce glioblastoma senescence, inhibit the growth of Temozolomide (HY-17364)-resistant cells and the secretion of the pro-inflammatory cytokine monocyte chemoattractant protein MCP-1.

HY-N0250R

Saikosaponin D (Standard)	Inhibitor
Saikosaponin D (Standard) is the analytical standard of Saikosaponin D. This product is intended for research and analytical applications. Saikosaponin D is a triterpene saponin isolated from Bupleurum, with anti-inflammatory, anti-bacterial, anti-tumor, and anti-allergic activities; Saikosaponin D inhibits selectin, STAT3 and NF-kB and activates estrogen receptor-β.

HY-168929

SHP1 activator 1	Inhibitor
SHP1 activator 1 (Compound 3n) is an activator for src homology-2 domain-containing protein tyrosine phosphatase 1(SHP1) with an EC₅₀ of 17.66 μM. SHP1 activator 1 inhibits the proliferation of ABC-DLBCL cells, induces apoptosis by inhibiting STAT3 signaling pathway. SHP1 activator 1 emitts blue and green fluorescence signalis in MDA-MB-231 cell, and can be used as a cell imaging agent.

HY-146666

STAT3-IN-9	Inhibitor
STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase.

HY-153902

DG-8	Inhibitor
DG-8 is a potent inhibitor of STAT3-dependent transcription (IC₅₀ 0.98 μM). DG-8 is a fluorescent probe that contains a fluorescent dansyl moiety.

HY-153023

PROTAC STAT3 degrader-2	Degrader
PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC₅₀ of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research. PROTAC STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-170393

iBFAR2	Inhibitor
iBFAR2, a BFAR inhibitor, restores the CD8+ TRM cell subset against solid tumors. iBFAR2 promotes JAK2-STAT1 association and STAT1 phosphorylation.

Stattic	STAT3				99.58%
AG490	Stat-3				99.86%
Cilengitide	STAT3 (^[3])				99.80%
Homoharringtonine	STAT3				99.96%
Ac-GpYLPQTV-NH2 acetate	STAT3, IC₅₀: 0.33 μM				99.38%
AS1517499			STAT6, IC₅₀: 21 nM		99.17%
Niclosamide	STAT3, IC₅₀: 0.25 μM (in HeLa cells)				99.91%
Artesunate	Stat-3				99.84%
C188-9	STAT3, Kd: 4.7 nM				99.90%
GYY4137	Stat-3				98.08%
NSC 74859	STAT3, IC₅₀: 86 μM				98.35%
Butyzamide	STAT3	STAT5			99.62%
Colivelin	STAT3				99.27%
TPCA-1	STAT3				99.66%
Astaxanthin	STAT3				≥98.0%
WP1066	STAT3				99.77%
Scutellarin	STAT3				99.04%
Napabucasin	STAT3				99.94%
Cryptotanshinone	STAT3, IC₅₀: 4.6 μM				98.80%
STAT5-IN-1		STAT5β, IC₅₀: 47 μM			98.35%
Pimozide	STAT3	STAT5			99.91%
Colivelin TFA	STAT3				99.52%
SD-36	STAT3, Kd: 50 nM				99.73%
Diosgenin	STAT3				99.35%
Saikosaponin D	STAT3				98.76%
AC-4-130		STAT5			99.93%
Cucurbitacin I	STAT3				99.44%
AS2863619		STAT5			99.94%
Morusin	STAT3				99.94%
SH-4-54	STAT3, Kd: 300 nM	STAT5, Kd: 464 nM			99.80%
SI-109	STAT3, Ki: 9 nM				99.91%
Alantolactone	STAT3				99.94%
SC-43	p-STAT3				99.02%
BP-1-102	STAT3, IC₅₀: 6.8 μM				99.52%
Nifuroxazide	STAT3				99.90%
AK-2292		STAT5, DC₅₀: 0.10 μM			99.73%
YM-341619			STAT6, IC₅₀: 0.70 nM		99.06%
STAT3-IN-1	Stat-3, IC₅₀: 1.82 μM (in HT29 cells) Stat-3, IC₅₀: 2.14 μM (in MDA-MB 231 cells)
AS1810722			STAT6, IC₅₀: 1.9 nM		98.14%
Erasin	STAT3, IC₅₀: 9.7 μM			STAT1, IC₅₀: 24 μM
NSC-370284	STAT3	STAT5
Brevilin A	STAT3, IC₅₀: 10.6 μM				99.86%
1-Stearoyl-sn-glycero-3-phosphocholine	p-STAT3				99.53%
Peramivir	STAT3				99.32%
Atractylenolide II	p-STAT3				99.94%
Stafia-1		STAT5a, Ki: 10.9 μM STAT5a, IC₅₀: 22.2 μM			99.37%
Broussonin E	STAT3				98.18%
Flubendazole	STAT3				99.33%
STAT3-IN-3	STAT3				98.40%
HJC0152	STAT3				99.76%
HO-3867	STAT3				99.67%
BD750		STAT5			99.10%
STX-0119	STAT3, IC₅₀: 74 μM (STAT3 transcription)				99.21%
Perindopril erbumine	STAT3				99.98%
Picroside I			STAT6		99.55%
GMB-475		STAT5			98.98%
LLL12	p-STAT3				99.45%
Garcinone D	p-STAT3				99.88%
Stafib-1		STAT5b, IC₅₀: 154 nM			≥98.0%
Cenisertib		STAT5			99.86%
STAT3-IN-25	STAT3				99.36%
OSM-SMI-10B	p-STAT3				99.28%
Ginkgolic acid C17:1	STAT3				99.90%
IST5-002		STAT5a, IC₅₀: 1.5 μM STAT5b, IC₅₀: 3.5 μM			99.36%
inS3-54A18	STAT3				99.53%
Triacetylresveratrol	STAT3				99.58%
Corylifol A	STAT3, IC₅₀: 0.81 μM				99.90%
KT-333	STAT3
Mogrol	STAT3				99.76%
STAT3-IN-12	STAT3				99.92%
Perindopril	STAT3				98.11%
STAT5-IN-2		STAT5, EC₅₀: 9 μM (in K562 cells) STAT5, EC₅₀: 5 μM (in KU812 cells )			99.08%
Ochromycinone	STAT3				98.29%
Garcinone C	Stat-3				99.66%
Reticuline	STAT3				98.91%
Golotimod hydrochloride	STAT3				99.79%
HODHBt		STAT5			99.93%
Protosappanin A	STAT3				99.98%
LL-K8-22				STAT1	99.76%
Tetramethylcurcumin	STAT3				99.91%
Balsalazide	STAT3				99.34%
HJC0416 hydrochloride	STAT3				98.68%
STAT3-IN-15	STAT3				98.99%
YMU1	STAT3				99.19%
ASP3026	STAT3				99.88%
AS2863619 free base		STAT5			99.87%
STAT3-IN-17	STAT3				≥98.0%
OK2	p-STAT3
SC99	STAT3				98.96%
Golotimod	STAT3				98.04%
PROTAC FLT-3 degrader 1		STAT5			99.74%
Equisetin	STAT3				99.40%
1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea	p-STAT3				98.02%
SB02024				STAT1	99.7%
Balsalazide sodium hydrate	STAT3				99.61%
WB436B	STAT3				99.93%
MNK8	STAT3				99.76%
Vanicoside B	STAT3				99.82%
APTSTAT3-9R	STAT3
ENMD-1198	STAT3				98.87%
UC-514321	STAT3	STAT5			≥98.0%
SH5-07	STAT3, IC₅₀: 3.9 μM				≥98.0%
Syk-IN-6	STAT3	STAT5
SD-1029	STAT3
Iminostilbene	STAT3				99.34%
Eflepedocokin alfa	STAT3				≥99.0%
Pimozide-d₄	STAT3	STAT5			≥98.0%
Galiellalactone	STAT3, IC₅₀: 250-500 nM
Biflorin				STAT1	99.54%
Stafia-1-dipivaloyloxymethyl ester		STAT5a			98.31%
Eupalinolide K	STAT3				99.20%
Niclosamide monohydrate	STAT3, IC₅₀: 0.25 μM (in HeLa cells)
SD-1008	STAT3				99.10%
STAT3-IN-8	STAT3
KT-333 diammonium	STAT3
YSY01A	Stat-3
c-Met-IN-24	STAT3, IC₅₀: 4.7 μM
STAT3-IN-37	STAT3
STAT3 HiBiT degrader 1	STAT3
STAT3-IN-38	STAT3, Kd: 45.33 μM
STAT3-IN-29	STAT3
VEGFR-2/STAT-3-IN-1	STAT3, IC₅₀: 5.63 nM
8α-Tigloyloxyhirsutinolide 13-O-acetate	STAT3
STAT1/3-IN-1	STAT3			STAT1
KT-333 ammonium	STAT3
WR-S-462	STAT3, Kd: 58 nM
JAK1/STAT3-IN-1	STAT3
FLT3-IN-28		STAT5
SD-436	STAT3, IC₅₀: 19 nM	STAT5, IC₅₀: >10 μM	STAT6, IC₅₀: >10 μM	STAT1, IC₅₀: 270 nM
STAT3/AKT-IN-1	Stat-3
ROCK2-IN-7	Stat-3
Anti-inflammatory agent 92	STAT3
STAT3-IN-41	STAT3
Golotimod TFA	STAT3
HJC0416	STAT3
HJC0123	STAT3
HAT-SIL-TG-1&AT	STAT3	STAT5
7-epi-Isogarcinol	STAT3
Cernuumolide J	Stat-3
Atractylenolide II (Standard)	p-STAT3
Antitumor agent-73	STAT3
STAT3-IN-5	p-STAT3, EC₅₀: 170 nM
K882	Stat-3
STAT3-IN-32	STAT3
WB518	STAT3 p-STAT3
Hsp110-STAT3 interaction-IN-2	STAT3
Ac-GpYLPQTV-NH2	STAT3, IC₅₀: 0.33 μM
STAT3-IN-9	STAT3
PROTAC STAT3 degrader-2	STAT3, ID₅₀: 3.54 μM
Ascochlorin	STAT3
Tyk2-IN-22-d₃		STAT5
1-Stearoyl-sn-glycero-3-phosphocholine-d₃₅	p-STAT3
NW16	STAT3, Kd: 11.0 μM
15(R)-Lipoxin A4			STAT6
Furowanin A	STAT3
Antitumor agent-195	STAT3, IC₅₀: 0.52 μM
STAT3-IN-10	STAT3, IC₅₀: 5.18 μM
Balsalazide disodium	STAT3
GYY4137 (GMP)	Stat-3
CHMFL-48		STAT5
DETD-35	Stat-3
STAT3-IN-39	STAT3
TM-233	Stat-3
BP-1-108		STAT5, Ki: 8.3 μM
PMMB-187	Stat-3, IC₅₀: 1.81 μM

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STAT

STAT

STAT Isoform Specific Products:

STAT Isoform Specific Products:

STAT Related Products (418)

Antibodies (25)

STAT Isoform Comparison

STAT Related Products (418):