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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

HL-60 cell

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (5) Akt (1) AMPK (2) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (40) Autophagy (12) Bacterial (4) Bcl-2 Family (2) Bombesin Receptor (1) Calcium Channel (1) Cannabinoid Receptor (2) Casein Kinase (1) Caspase (6) Cathepsin (1) CDK (4) Checkpoint Kinase (Chk) (1) COX (2) CXCR (1) Cytochrome P450 (3) DNA Alkylator/Crosslinker (1) DNA-PK (1) DNA/RNA Synthesis (7) EBI2/GPR183 (1) Endogenous Metabolite (11) Epigenetic Reader Domain (4) Farnesyl Transferase (4) Ferroptosis (1) Filovirus (1) FLT3 (1) Fluorescent Dye (1) Fungal (1) Glyoxalase (GLO) (1) HDAC (8) Histone Acetyltransferase (1) Histone Methyltransferase (1) HIV (2) Integrin (2) Interleukin Related (3) Isotope-Labeled Compounds (6) Lipoxygenase (2) MNK (1) Molecular Glues (1) mTOR (1) NF-κB (3) NO Synthase (2) Parasite (2) Phosphatase (4) PI3K (2) Pim (1) PKA (1) Polo-like Kinase (PLK) (1) Potassium Channel (1) Prostaglandin Receptor (1) PROTACs (6) RANKL/RANK (1) RAR/RXR (1) Reactive Oxygen Species (3) Ser/Thr Protease (1) Serotonin Transporter (8) SphK (1) Src (1) Telomerase (1) Topoisomerase (1) Transferrin Receptor (1) VD/VDR (2) VEGFR (1) Xanthine Oxidase (2)
By Research Areas:	Cancer (131) Cardiovascular Disease (2) Endocrinology (2) Infection (11) Inflammation/Immunology (28) Metabolic Disease (7) Neurological Disease (11)

By Targets:

ADC Cytotoxin (5)

Akt (1)

AMPK (2)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

Apoptosis (40)

Autophagy (12)

Bacterial (4)

Bcl-2 Family (2)

Bombesin Receptor (1)

Calcium Channel (1)

Cannabinoid Receptor (2)

Casein Kinase (1)

Caspase (6)

Cathepsin (1)

CDK (4)

Checkpoint Kinase (Chk) (1)

COX (2)

CXCR (1)

Cytochrome P450 (3)

DNA Alkylator/Crosslinker (1)

DNA-PK (1)

DNA/RNA Synthesis (7)

EBI2/GPR183 (1)

Endogenous Metabolite (11)

Epigenetic Reader Domain (4)

Farnesyl Transferase (4)

Ferroptosis (1)

Filovirus (1)

FLT3 (1)

Fluorescent Dye (1)

Fungal (1)

Glyoxalase (GLO) (1)

HDAC (8)

Histone Acetyltransferase (1)

Histone Methyltransferase (1)

HIV (2)

Integrin (2)

Interleukin Related (3)

Isotope-Labeled Compounds (6)

Lipoxygenase (2)

MNK (1)

Molecular Glues (1)

mTOR (1)

NF-κB (3)

NO Synthase (2)

Parasite (2)

Phosphatase (4)

PI3K (2)

Pim (1)

PKA (1)

Polo-like Kinase (PLK) (1)

Potassium Channel (1)

Prostaglandin Receptor (1)

PROTACs (6)

RANKL/RANK (1)

RAR/RXR (1)

Reactive Oxygen Species (3)

Ser/Thr Protease (1)

Serotonin Transporter (8)

SphK (1)

Src (1)

Telomerase (1)

Topoisomerase (1)

Transferrin Receptor (1)

VD/VDR (2)

VEGFR (1)

Xanthine Oxidase (2)

By Research Areas:

Cancer (131)

Cardiovascular Disease (2)

Endocrinology (2)

Infection (11)

Inflammation/Immunology (28)

Metabolic Disease (7)

Neurological Disease (11)

151

Inhibitors & Agonists

Fluorescent Dye

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Itk TOPK NAMPT ALCAM/CD166 GDNF Receptor VISTA BCL6 Tim3 BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113978

6-Formylpterin	Xanthine Oxidase Apoptosis Reactive Oxygen Species	Metabolic Disease
6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells .

HY-107471

CB2 receptor agonist 3 GP2a	Cannabinoid Receptor	Cancer
CB2 receptor agonist 3 is a robust and selective CB2 cannabinoid agonist with K_is of 7.6 and 900 nM for CB2 and CB1, respectively. CB2 receptor agonist 3 significantly increases P-ERK 1/2 expression in HL-60 cells .

HY-155390

Caspase-3 activator 3	Caspase Apoptosis	Cancer
Caspase-3 activator 3 (compound 2h) induces apoptosis in HL-60 and K562 cells via significant caspase 3 activation. Caspase-3 activator 3 shows antileukemic acticity against HL-60 and K562 cells, with IC₅₀ values of 42.89 and 33.61 μM, respectively .

HY-N10531

Lewis a trisaccharide Lewis a	Others	Others
Lewis a trisaccharide (Lewis a) is a trisaccharide that has been found to be present in the glycan structures of spermatozoa. Lewis a trisaccharide also is a major component of the glycan structures on the surface of HL-60 cells .

HY-N8658

Epinodosin	Others	Infection Inflammation/Immunology
Epinodosin is a diterpenoid. Epinodosin has moderate cytotoxicity against HL-60 cells with IC₅₀ value of 10.4 μM. Epinodosin can be used for the research of inflammatory diseases .

HY-158019

Anticancer agent 196	DNA/RNA Synthesis	Cancer
Anticancer agent 196 (compound 1) shows cell cytotoxicity with IC₅₀ values of 7.69 µM and 54.2 µM for HL-60 cells and A549 cells, respectively. Anticancer agent 196 can induce DNA damage .

HY-158020

Anticancer agent 197	DNA/RNA Synthesis	Cancer
Anticancer agent 197 (compound 2b) shows cell cytotoxicity with IC₅₀ values of 10.03 µM and 73.54 µM for HL-60 cells and A549 cells, respectively. Anticancer agent 197 can induce DNA damage .

HY-N10364

6β,7β-Epoxyasteriscunolide A	Others	Cancer
6β,7β-Epoxyasteriscunolide A, a sesquiterpenoid, shows cytotoxicity against the HL-60 and MOLT-3 leukemia cell lines, with IC₅₀s range 4.1-5.4 μM .

HY-N10206

11-epi-Chaetomugilin I	Endogenous Metabolite	Cancer
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-N12108

Forphenicine	Phosphatase	Infection Inflammation/Immunology Cancer
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .

HY-112328

Fascaplysin	Apoptosis Autophagy Reactive Oxygen Species CDK	Infection Cancer
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity .

HY-N8088

Neolancerin	Others	Cancer
Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

HY-N7338

Yadanziolide C	Others	Cancer
Yadanziolide C is a quassinoid with antiproliferative and differentiation-inducing properties in promyelocytic HL-60 cells .

HY-129583

Lepidiline A	Others	Cancer
Lepidiline A shows cytotoxic activity against HL-60 cells with an IC₅₀ of 32.3 μM.

HY-N10127

Lepidiline C	Others	Cancer
Lepidiline C shows cytotoxic activity against HL-60 cells with an IC₅₀ of 27.7 μM.

HY-17563R

2'-Deoxyguanosine (Standard)	Endogenous Metabolite	Cancer
2'-Deoxyguanosine (Standard) is the analytical standard of 2'-Deoxyguanosine. This product is intended for research and analytical applications. 2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells . In Vitro: 2'-Deoxyguanosine inhibits the clonal growth of HL-60 and K562 leukemia cells with IC₅₀ values of 50 and 80 μM, respectively .

HY-N8477

Isolupalbigenin	NO Synthase	Inflammation/Immunology
Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC₅₀ of 5.1 μM .

HY-N10208

Aspericin C	Endogenous Metabolite	Cancer
Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC₅₀=14.6, 7.1, 61.4, and 24.2 μM, respectively) .

HY-N7562

Ustusolate E	Others	Cancer
Ustusolate E is a drimane sesquiterpene with moderate cytotoxicity against HL-60 cells with an IC₅₀ value of 9.0 μM .

HY-N1081A

Viteralone (S)-Viteralone	Others	Cancer
Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

HY-108277

Ginsenoside F5	Apoptosis	Cancer
Ginsenoside F5, from crude extracts of flower buds of Panax ginseng, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway .

HY-111008

Trimidox VF-233	DNA/RNA Synthesis	Cancer
Trimidox (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-111008A

Trimidox hydrochloride VF-233 hydrocHLoride	DNA/RNA Synthesis	Cancer
Trimidox hydrochloride (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox hydrochloride inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-N10852

Shikokianin	Others	Cancer
Shikokianin, a diterpenoid, shows significant cytotoxicity against HL-60 and A-549 cells with IC₅₀ values of 3.4 μM and 18.8 μM, respectively .

HY-N9339

Norglaucine (+)-Norglaucine	Others	Cancer
Norglaucine ((+)-Norglaucine), a cytotoxic alkaloid, exhibits cytotoxicity towards the tumor cell lines B16-F10, HepG2, K562 and HL-60 cells .

HY-136684

BrBzGCp2 2 Publications Verification S-p-Bromobenzylglutathione cyclopentyl diester	Glyoxalase (GLO)	Neurological Disease Cancer
BrBzGCp2 is a Glyoxalase 1 (GLO1) inhibitor, with a GC₅₀ of 4.23 μM in HL-60 cells. BrBzGCp2 possesses antitumor and neuroprotective activity .

HY-D1267

PAO-Nap	Apoptosis	Cancer
PAO-Nap is the modified PAO attached a naphthalimide fluorophore using aminocaproic acid as a linker. PAO induces oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase .

HY-124122

BPTQ	VEGFR Checkpoint Kinase (Chk) Apoptosis Caspase Bcl-2 Family	Cancer
BPTQ is a potent inhibitor against VEGFR1 and CHK2 with IC₅₀ values of 0.54 and 1.70 µmol/L, respectively. BPTQ is also an intercalator of DNA with anticancer activities. BPTQ inhibits the proliferation of HL-60 cells by arresting cells at S and G2/M phase with an IC₅₀ value of 12 µmol/L. BPTQ also activates the mitochondria-mediated Apoptosis pathway by a decrease in mitochondrial membrane potential, increase in the Bax:Bcl-2 ratio and activation of caspases .

HY-33350

Clofilium tosylate 1 Publications Verification	Potassium Channel Apoptosis	Cardiovascular Disease Cancer
Clofilium tosylate, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Antiarrhythmic agent .

HY-N10392

(S)-Erypoegin K	Apoptosis	Cancer
(S)-Erypoegin K is a potent anticancer agent. (S)-Erypoegin K shows potent anti-proliferative activity against HL-60 cells. (S)-Erypoegin K induces apoptosis .

HY-117220

Aspochalasin M	Others	Cancer
Aspochalasin M is a colorless solid. Aspochalasin M shows modest activity against HL-60 cells with an IC₅₀ of 20.0 μM. Aspochalasin M has the potential for the research of leukemic disease .

HY-N9159

Piptocarphin F	Others	Cancer
Piptocarphin F (Compound 5) is a sesquiterpene lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell line HL-60 (IC₅₀=5.69 μmol*L ^-1) .

HY-159610

PROTAC GSPT1 degrader-2	Molecular Glues	Cancer
PROTAC GSPT1 degrader-2 (compound A) is a GSPT1 molecule glue with more than 95% degradation. GSPT1 degrader-8 inhibits cell viability in HL-60 cells with an IC₅₀ of 10 nM .

HY-N0753

Eupalinolide B	Others	Cancer
Eupalinolide B is a germacrane sesquiterpene isolated from Eupatorium lindleyanum. Eupalinolide B demonstrates potent cytotoxicity against A-549, BGC-823 and HL-60 tumour cell lines .

HY-N8098

Pulchinenoside E2	Others	Cancer
Pulchinenoside E2 (Compound 8) is a triterpene saponin isolated from the roots of Pulsatilla chinensis. Pulchinenoside E2 shows cytotoxic to HL-60 cells with an IC₅₀ value of 2.6 µg/mL .

HY-N6694

4-Bromo A23187	Calcium Channel Bacterial Apoptosis Antibiotic	Infection Cancer
4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187, a calcium modulator, induces apoptosis in different cells, including HL-60 cells .

HY-131555

p-Decylaminophenol	Apoptosis	Cancer
p-Decylaminophenol is an aminophenol analog with anticancer activities. p-Decylaminophenol induces apoptosis of HL60 cells .

HY-N2113

Glaucocalyxin B	Autophagy	Cancer
Glaucocalyxin B is an ent kaurane diterpenoid isolated from the Chinese traditional medicine Rabdosia japonica with anticancer and antitumor activity; decreases the growth of HL-60 cells with an IC₅₀ of approximately 5.86 μM at 24 h.

HY-N7154

2,3-O-Isopropylidenyl euscaphic acid	Others	Cancer
2,3-O-Isopropylidenyl euscaphic acid, a triterpenoid from the seeds of blackberry (Rubus fructicosus), exhibits cytotoxic activity towards HL-60 human leukaemia cells with IC₅₀ value of 72.8 μM .

HY-N10765

Salvinolone	Bacterial	Inflammation/Immunology Cancer
Salvinolone is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). Salvinolone shows cytotoxic activity with an IC₅₀ of 47.6 μM against the HL-60 tumor cell line for 72 h .

HY-N12534

Monaspin B	Apoptosis	Cancer
Monaspin B is a natural product produced by the co-culture of Monascus purpureus and Aspergillus oryzae. Monaspin B exerts anti-proliferation activity by inducing apoptosis of HL-60 cells, IC₅₀ 160 nM. Monaspin B has antitumor activity .

HY-W588250

Surfactin C1	Integrin	Inflammation/Immunology
Surfactin C1 is an amphiphilic biosurfactants. Surfactin C1 inhibits leukemic cell (HL-60) adhesion to human umbilical vein endothelial cells (HUVEC). Surfactin C1 inhibits adhesion melecules expression, such as ICAM-1 and VCAM-1 .

HY-W267446

6-Methoxy-4-methylcoumarin	Others	Cancer
6-Methoxy-4-methylcoumarin is an ether compound containing a substituted benzylamino group, exhibiting antitumor activity, and can inhibit the growth of cell lines such as leukemia cell line HL-60, lung cancer, bladder cancer, prostate cancer, and rectal cancer .

HY-N7623

Ursonic acid methyl ester	Others	Cancer
Ursonic acid methyl ester is an esterified derivative of Ursolic acid (HY-N0140). Ursonic acid methyl ester shows growth inhibitory activity against four tumor cell lines, HL-60, BGC, Bel-7402 and Hela with ED₅₀ values of >100 µg/ml .

HY-106784

Ajoene	Fungal Apoptosis	Infection Cancer
Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities .

HY-129578

Asperphenamate	Autophagy Cathepsin	Infection Inflammation/Immunology Cancer
Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC₅₀ values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively .

HY-155066

FD274	PI3K mTOR	Cancer
FD274 is a highly potent PI3K/mTOR dual inhibitor with IC₅₀s of 0.65 nM, 1.57 nM, 0.65 nM, 0.42 nM, and 2.03 nM against PI3Kα/β/γ/δ and mTOR, respectively. FD274 exhibits significant anti-proliferation of AML cell lines (HL-60 and MOLM-16). FD274 demonstrates dose-dependent inhibition of tumor growth in the HL-60 xenograft model. FD274 has the potential for acute myeloid leukemia research .

HY-N1231

Sophoraflavanone G 1 Publications Verification Kushenol F	Apoptosis	Cancer
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.? Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways .

HY-135122

DC10SMe	ADC Cytotoxin DNA Alkylator/Crosslinker	Cancer
DC10SMe is a DNA alkylator, can be used in the synthesis of antibody-drug conjugate (ADC). DC10SMe exhibits IC₅₀s of 15 pM, 12 pM, and 12 pM for Ramos, Namalwa, and HL60/s cancer cells, respectively .

HY-155389

Caspase-3 activator 2	Caspase	Cancer
Caspase-3 activator 2 (Compound 2f) is a caspase 3 activator that induces apoptosis and can be used in cancer research. Caspase-3 activator 2 is cytotoxic to HL-60 cells and K562 cells, with IC₅₀ values of 33.52 μM and 76.90 μM respectively .

Cat. No.	Product Name	Type

HY-W127705

Quinacrine mustard dihydrochloride	Fluorescent Dyes/Probes
Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes .

Cat. No.	Product Name	Target	Research Area

HY-W588250

Surfactin C1	Integrin	Inflammation/Immunology
Surfactin C1 is an amphiphilic biosurfactants. Surfactin C1 inhibits leukemic cell (HL-60) adhesion to human umbilical vein endothelial cells (HUVEC). Surfactin C1 inhibits adhesion melecules expression, such as ICAM-1 and VCAM-1 .

HY-P3736

Myelopeptide-2 MP-2	Interleukin Related	Cancer
Myelopeptide-2 is a peptide originally isolated from the supernatant of porcine bone marrow cell cultures, can restore mitogenic reactivity of human T lymphocytes inhibited by HL-60 leukemia cells or measles virus conditions. Myelopeptide-2 also recover depressed interleukin-2 (IL-2) synthesis and interleukin-2 receptor (IL-2R) expression. Myelopeptide-2 involves in immunity homeostasis, is perspective to be applied in antitumor and antivirus research .

Cat. No.	Product Name	Target	Research Area

HY-P99272

Ulocuplumab BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody	CXCR	Cancer
Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8088

Neolancerin	Structural Classification other families Xanthones Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Others
Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells .

HY-129583

Lepidiline A	Alkaloids other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Others
Lepidiline A shows cytotoxic activity against HL-60 cells with an IC₅₀ of 32.3 μM.

HY-N10127

Lepidiline C	Alkaloids Structural Classification other families Classification of Application Fields Other Alkaloids Source classification Plants Disease Research Fields Cancer	Others
Lepidiline C shows cytotoxic activity against HL-60 cells with an IC₅₀ of 27.7 μM.

HY-N10531

Lewis a trisaccharide Lewis a	Structural Classification Natural Products Polysaccharides Classification of Application Fields Animals Other Diseases Disease Research Fields Saccharides	Others
Lewis a trisaccharide (Lewis a) is a trisaccharide that has been found to be present in the glycan structures of spermatozoa. Lewis a trisaccharide also is a major component of the glycan structures on the surface of HL-60 cells .

HY-N8658

Epinodosin	Achillea odorata L. Infection Structural Classification Classification of Application Fields Terpenoids Labiatae Diterpenoids Plants Inflammation/Immunology Disease Research Fields Biological Pesticide Research Agricultural Research	Others
Epinodosin is a diterpenoid. Epinodosin has moderate cytotoxicity against HL-60 cells with IC₅₀ value of 10.4 μM. Epinodosin can be used for the research of inflammatory diseases .

HY-N10364

6β,7β-Epoxyasteriscunolide A	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	Others
6β,7β-Epoxyasteriscunolide A, a sesquiterpenoid, shows cytotoxicity against the HL-60 and MOLT-3 leukemia cell lines, with IC₅₀s range 4.1-5.4 μM .

HY-N10206

11-epi-Chaetomugilin I	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-N12108

Forphenicine	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Phenols	Phosphatase
Forphenicine is a bacterial metabolite that is found in S. fulvoviridis and an inhibitor of alkaline phosphatase. Forphenicine inhibits the growth of HL-60 leukemia cells at 10 µM. Forphenicine also increases survival in a guinea pig model of experimental autoimmune encephalomyelitis (EAE) .

HY-112328

Fascaplysin	Infection Alkaloids Structural Classification Classification of Application Fields Animals Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	Apoptosis Autophagy Reactive Oxygen Species CDK
Fascaplysin is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity .

HY-N7338

Yadanziolide C	Simaroubaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer Brucea javanica (L.) Merr.	Others
Yadanziolide C is a quassinoid with antiproliferative and differentiation-inducing properties in promyelocytic HL-60 cells .

HY-17563R

2'-Deoxyguanosine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Immune System Disorder Microorganisms Source classification Disease markers Endocrine diseases Endogenous metabolite	Endogenous Metabolite
2'-Deoxyguanosine (Standard) is the analytical standard of 2'-Deoxyguanosine. This product is intended for research and analytical applications. 2’-Deoxyguanosine (Deoxyguanosine) is a purine nucleoside with a variety of biological activities. 2’-Deoxyguanosine can induce DNA division in mouse thymus cells. 2’-Deoxyguanosine is a potent cell division inhibitor in plant cells . In Vitro: 2'-Deoxyguanosine inhibits the clonal growth of HL-60 and K562 leukemia cells with IC₅₀ values of 50 and 80 μM, respectively .

HY-N8477

Isolupalbigenin	Structural Classification Flavonoids Source classification Maclura tricuspidata Carriere Plants Moraceae Isoflavones	NO Synthase
Isolupalbigenin is an inhibitor of NO. Isolupalbigenin has anti-proliferative activity on HL-60 cells with an IC₅₀ of 5.1 μM .

HY-N10208

Aspericin C	Natural Products Microorganisms Classification of Application Fields Source classification Marine natural products Disease Research Fields Marine microorganism Cancer	Endogenous Metabolite
Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC₅₀=14.6, 7.1, 61.4, and 24.2 μM, respectively) .

HY-N7562

Ustusolate E	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Others
Ustusolate E is a drimane sesquiterpene with moderate cytotoxicity against HL-60 cells with an IC₅₀ value of 9.0 μM .

HY-N1081A

Viteralone (S)-Viteralone	Terpenoids Verbenaceae Sesquiterpenes Plants Vitex negundo Linn.	Others
Viteralone (compound 5) is a natural product that can be isolated from Vitex negundo. Viteralone is cytotoxic to HL-60 cancer cells .

HY-108277

Ginsenoside F5	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Apoptosis
Ginsenoside F5, from crude extracts of flower buds of Panax ginseng, remarkably inhibits the growth of HL-60 cells by the apoptosis pathway .

HY-N10852

Shikokianin	Structural Classification Tanacetum cinerariifolium (Treviranus) Schultz Bipontinus Terpenoids Labiatae Source classification Diterpenoids Plants	Others
Shikokianin, a diterpenoid, shows significant cytotoxicity against HL-60 and A-549 cells with IC₅₀ values of 3.4 μM and 18.8 μM, respectively .

HY-N9339

Norglaucine (+)-Norglaucine	Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Others
Norglaucine ((+)-Norglaucine), a cytotoxic alkaloid, exhibits cytotoxicity towards the tumor cell lines B16-F10, HepG2, K562 and HL-60 cells .

HY-N10392

(S)-Erypoegin K	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Erythrina poeppigiana Plants Disease Research Fields Isoflavones Cancer	Apoptosis
(S)-Erypoegin K is a potent anticancer agent. (S)-Erypoegin K shows potent anti-proliferative activity against HL-60 cells. (S)-Erypoegin K induces apoptosis .

HY-117220

Aspochalasin M	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Others
Aspochalasin M is a colorless solid. Aspochalasin M shows modest activity against HL-60 cells with an IC₅₀ of 20.0 μM. Aspochalasin M has the potential for the research of leukemic disease .

HY-N9159

Piptocarphin F	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Dalbergia frutescens (Vell.) Britton	Others
Piptocarphin F (Compound 5) is a sesquiterpene lactone. Piptocarphin F shows cytotoxic activity on human leukemia cell line HL-60 (IC₅₀=5.69 μmol*L ^-1) .

HY-N0753

Eupalinolide B	Classification of Application Fields Melilotus albus Desr. Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Cancer	Others
Eupalinolide B is a germacrane sesquiterpene isolated from Eupatorium lindleyanum. Eupalinolide B demonstrates potent cytotoxicity against A-549, BGC-823 and HL-60 tumour cell lines .

HY-N8098

Pulchinenoside E2	Triterpenes Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Source classification Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Cancer	Others
Pulchinenoside E2 (Compound 8) is a triterpene saponin isolated from the roots of Pulsatilla chinensis. Pulchinenoside E2 shows cytotoxic to HL-60 cells with an IC₅₀ value of 2.6 µg/mL .

HY-N2113

Glaucocalyxin B	Structural Classification Classification of Application Fields Terpenoids Labiatae Sesquiterpenes Source classification Plants Glycyrrhiza lepidota Pursh Disease Research Fields Cancer	Autophagy
Glaucocalyxin B is an ent kaurane diterpenoid isolated from the Chinese traditional medicine Rabdosia japonica with anticancer and antitumor activity; decreases the growth of HL-60 cells with an IC₅₀ of approximately 5.86 μM at 24 h.

HY-N7154

2,3-O-Isopropylidenyl euscaphic acid	Triterpenes Classification of Application Fields Terpenoids Source classification Rosaceae Dianthus rupicola Biv. Plants Disease Research Fields Cancer	Others
2,3-O-Isopropylidenyl euscaphic acid, a triterpenoid from the seeds of blackberry (Rubus fructicosus), exhibits cytotoxic activity towards HL-60 human leukaemia cells with IC₅₀ value of 72.8 μM .

HY-N10765

Salvinolone	Structural Classification Stilbenes Terpenoids Labiatae Source classification Diterpenoids Plants Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Bacterial
Salvinolone is active against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). Salvinolone shows cytotoxic activity with an IC₅₀ of 47.6 μM against the HL-60 tumor cell line for 72 h .

HY-N12534

Monaspin B	Structural Classification Natural Products Microorganisms Source classification	Apoptosis
Monaspin B is a natural product produced by the co-culture of Monascus purpureus and Aspergillus oryzae. Monaspin B exerts anti-proliferation activity by inducing apoptosis of HL-60 cells, IC₅₀ 160 nM. Monaspin B has antitumor activity .

HY-W267446

6-Methoxy-4-methylcoumarin	Structural Classification Citrus × aurantium Linnaeus Source classification Rutaceae Coumarins Phenylpropanoids Plants Daphniphyllum macropodum Miq.	Others
6-Methoxy-4-methylcoumarin is an ether compound containing a substituted benzylamino group, exhibiting antitumor activity, and can inhibit the growth of cell lines such as leukemia cell line HL-60, lung cancer, bladder cancer, prostate cancer, and rectal cancer .

HY-106784

Ajoene	Infection Natural Products Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields A．Sativam L. var．Viviparum Regel	Fungal Apoptosis
Ajoene, a garlic-derived compound, is an antithrombotic and antifungal agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities .

HY-129578

Asperphenamate	Infection Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Inflammation/Immunology	Autophagy Cathepsin
Asperphenamate, a fungal metabolite of Aspergillus flatiipes with anti-cancer effect, exhibits IC₅₀ values of 92.3 μM, 96.5 μM and 97.9 μM in T47D, MDA-MB-231 and HL-60 cells, respectively .

HY-N1231

Sophoraflavanone G 1 Publications Verification Kushenol F	Structural Classification Flavonoids Classification of Application Fields Leguminosae Flavonones Source classification Phenols Polyphenols Sophora flavescens Aiton Plants Disease Research Fields Cancer	Apoptosis
Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties.? Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways .

HY-N3615

Confluentin	Structural Classification Natural Products Rhododendron simsii Planch. Source classification Plants Ericaceae	Others
Confluentin can be isolated from Rhododendron dauricum. Confluentin shows weak cytotoxicity against human tumor cells (IC₅₀: 15.05, 17.08, 18.48, and 23.01 μM for HL-60, SMMC-7712, A-549, and MCF-7) .

HY-113455

9S-HODE Alpha-dimorphecolic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
9S-HODE (Alpha-dimorphecolic acid) is an octadecadienoic acid and the main active derivative of linoleic acid, which can reduce the viability of HL-60 cells and induce apoptosis. 9S-HODE is rich in lipid peroxidation (LPO) products and is almost an ideal marker for LPO .

HY-N7450

Icariside D2	Infection Structural Classification Natural Products Classification of Application Fields Source classification Plants Annonaceae Inflammation/Immunology Disease Research Fields Annona glabra Linn.	Angiotensin-converting Enzyme (ACE) Apoptosis HIV
Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC₅₀ value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis .

HY-N11928

Changnanic acid	Structural Classification Kadsura heteroclita (Roxb.) Craib Ketones, Aldehydes, Acids Source classification Plants Schisandraceae	Others
Changnanic acid (schisandrin) is a triterpene compound with potential anti-tumor effects. Changnanic acid exhibits moderate cytotoxic activity against human tumor cell lines Bel-7402, MCF-7 and HL-60, with IC₅₀s of 100 μM, 100 μM and 50.51 μM respectively .

HY-13516

Aloperine 4 Publications Verification	Infection Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Sophora alopecuroides L Plants Inflammation/Immunology Disease Research Fields	Apoptosis Autophagy Filovirus HIV
Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties . Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China . Aloperine induces apoptosis and autophagy in HL-60 cells .

HY-129334

Macrocalin B	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Tagetes minuta Linnaeus	Telomerase
Macrocalin B is a diterpenoid, which can be isolated from Isodon xerophilus. Macrocalin B inhibits the proliferation of cancer cells K562, HL-60, A549, MKN, CA and HCT with IC₅₀ of 2.81-171 μM. Macrocalin B inhibits the telomerase in K562 with an IC₅₀ in nanomolar level .

HY-101413

Iberin 1 Publications Verification NSC 321801	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Bacterial
Iberin (NSC 321801), a sulfoxide analogue of sulforaphane, is a naturally occurring member of isothiocyanate family. Iberin inhibits cell survival with an IC₅₀ of 2.3 μM in HL60 cell. Iberin induces apoptosis.

HY-N12153

Theasaponin E2	Structural Classification Polysaccharides Source classification Plants Camellia sinensis (L.) O. Ktze. Saccharides Theaceae	Others
Theasaponin E2 shows cytotoxicity against K562 and HL60 cells (IC₅₀: 14.7 μg/mL). Theasaponin E2 can be isolated from Camellia sinensis .

HY-N2513

β-Boswellic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC₅₀ values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases .

HY-N0381

Maackiain DL-Maackiain	Infection Natural Products Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	Parasite Apoptosis
Maackiain (DL-Maackiain) is isolated from Maackia amurensis Rupr.et Maxim. Maackiain (DL-Maackiain) is a larvicidal agent against Aedes aegypti mosquito.xp Parasitol with a LD₅₀ of 21.95 µg/mL . Maackiain (DL-Maackiain) induces fragmentations of DNA to oligonucleosomal-sized fragments that like a characteristic of apoptosis in the HL-60 cells .

HY-W728151

3-O-Caffeoylshikimic acid	Structural Classification Livistona chinensis (Jacq.) R. Br. ex Mart. Source classification Phenols Polyphenols Palmae Plants	Endogenous Metabolite
3-O-Caffeoylshikimic acid (Compound 8) is a phenolic and can be isolated from Livistona chinensis. 3-O-Caffeoylshikimic acid is an antioxidant agent. 3-O-Caffeoylshikimic acid inhibits the proliferation of human cancer cells HepG2, HL-60, K562, and CNE-1 with IC₅₀s of 5–150 μM .

HY-N3210

Nb-Demethylechitamine	Apocynaceae Structural Classification Alkaloids Source classification Plants Indole Alkaloids Alstonia rostrata C. E. C. Fischer	Others
Nb-Demethylechitamine is an alkaloid isolated from the methanol extract of Alstonia rostrata twigs. Nb-Demethylechitamine has in vitro cytotoxic activity against several human cancer cell lines, including human myeloid leukemia HL-60, liver cancer SMMC-7721, lung cancer A-549, breast cancer MCF-7, and colon cancer SW480 cells .

HY-N1231R

Sophoraflavanone G (Standard)	Structural Classification Flavonoids Leguminosae Flavonones Source classification Phenols Polyphenols Sophora flavescens Aiton Plants	Apoptosis
Sophoraflavanone G (Standard) is the analytical standard of Sophoraflavanone G. This product is intended for research and analytical applications. Sophoraflavanone G (Kushenol F) is iaolated from Sophora flavescens and shows anti-tumor and anti-inflammatory properties. Sophoraflavanone G (Kushenol F) induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways .

HY-N3097

Pellitorine	Alkaloids Classification of Application Fields Other Alkaloids Source classification Piperaceae Plants Disease Research Fields Piper nigrum Linn. Biological Pesticide Research Cancer Agricultural Research	Others
Pellitorine is a compound isolated from the roots of Piper nigrum. Pellitorine shows strong cytotoxic activities against HL60 and MCT-7 cell lines. Pellitorine has the potential for the research of cancer diseases .

HY-N1746

(2S)-2'-Methoxykurarinone 2'-O-Methylkurarinone	Structural Classification Classification of Application Fields Source classification Metabolic Disease Sophora flavescens Aiton Plants Flavonoids Leguminosae Flavonones Phenols Polyphenols Inflammation/Immunology Disease Research Fields	RANKL/RANK
(2S)-2'-Methoxykurarinone, a compound isolated from the roots of Sophora flavescens, has anti-inflammatory, antipyretic, antidiabetic, and antineoplastic effects. (2S)-2'-Methoxykurarinone (MK) inhibits osteoclastogenesis and bone resorption through down-regulation of RANKL signaling. (2S)-2'-Methoxykurarinone (MK) displays cytotoxic activity against human myeloid leukemia HL-60 cells .

HY-N2513R

β-Boswellic acid (Standard)	Structural Classification other families Classification of Application Fields Terpenoids Source classification Boswellia serrata Plants Burseraceae Disease Research Fields Cancer	Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid (Standard) is the analytical standard of β-Boswellic acid. This product is intended for research and analytical applications. β-Boswellic acid is isolated from the gum resin of Boswellia serrata. β-Boswellic acid is a nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation . β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells .

HY-N1710

28-Deoxonimbolide	Triterpenes Structural Classification Terpenoids Source classification Azadirachta indica A. Juss. Plants Meliaceae	Apoptosis Caspase
28-Deoxonimbolide is a nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways .

HY-N3097R

Pellitorine (Standard)	Alkaloids Other Alkaloids Source classification Piperaceae Plants Piper nigrum Linn.	Others
Pellitorine (Standard) is the analytical standard of Pellitorine. This product is intended for research and analytical applications. Pellitorine is a compound isolated from the roots of Piper nigrum. Pellitorine shows strong cytotoxic activities against HL60 and MCT-7 cell lines. Pellitorine has the potential for the research of cancer diseases .

HY-N11709

Theasaponin E1	Triterpenes Structural Classification Terpenoids Source classification Plants Camellia sinensis (L.) O. Ktze. Theaceae	Others
Theasaponin E1 is a tea saponin isolated from tea seeds. Theasaponin E1 exhibits potential antitumor activity against human tumor cell lines K562 and HL60. Theasaponin E1 also has quinone reductase (QR)-inducing activity and can act as an anti-tumor agent for cancer prevention .

Cat. No.	Product Name	Chemical Structure

HY-B1490S

Imipramine-d4 hydrochloride

Imipramine-d₄ (hydrochloride) is the deuterium labeled Imipramine hydrochloride. Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6].

HY-B1490AS

Imipramine-d6

Imipramine-d₆ is the deuterium labeled Imipramine hydrochloride. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6].

HY-B1490AS1

Imipramine-d4

Imipramine-d₄ is deuterium labeled Imipramine. Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6].

HY-B1490S1

Imipramine-d3 hydrochloride

Imipramine-d₃ (hydrochloride) is deuterium labeled Imipramine (hydrochloride). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects[1][2][3][4][5][6].

HY-B1490AS3

Imipramine-d4-1

Imipramine-d4-1 is the deuterium labeled Imipramine (HY-W010179). Imipramine is an orally active tertiary amine tricyclic antidepressant. Imipramine is a Fascin1 inhibitor with antitumor activities. Imipramine also inhibits serotonin transporter with an IC₅₀ value of 32 nM. Imipramine stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine shows neuroprotective and immunomodulatory effects .

HY-113455S1

9(S)-HODE-13C18
9(S)-HODE- ¹³C₁₈ ((+)-α-Dimophecolic acid- ¹³C₁₈) is ¹³C labeled 9S-HODE. 9S-HODE (Alpha-dimorphecolic acid) is an octadecadienoic acid and the main active derivative of linoleic acid, which can reduce the viability of HL-60 cells and induce apoptosis. 9S-HODE is rich in lipid peroxidation (LPO) products and is almost an ideal marker for LPO .

HY-109015S

Tucidinostat-d4
Tucidinostat-d₄ is the deuterium labeled Tucidinostat. Tucidinostat is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, respectively[1].

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