Search Result
Results for "
Inverse
" in MedChemExpress (MCE) Product Catalog:
10
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-132909
-
-
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- HY-49076
-
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ROR
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Cancer
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RORγ inverse agonist 1 is the inverse agonist of RORγ .
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-
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- HY-122737
-
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ROR
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Inflammation/Immunology
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RORγt Inverse agonist 8 is a potent, selective, orally bioavailable RORγt inverse agonist, with an IC50 of 19 nM for human RORγt-LBD .
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-
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- HY-168179
-
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ROR
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Inflammation/Immunology
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RORγt inverse agonist 32 (compound b14) is orally active. RORγt inverse agonist 32 can be used in inflammation research .
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-
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- HY-143271
-
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ROR
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Inflammation/Immunology
|
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RORγt inverse agonist 29 is a potent, orally active and selective RORγt inverse agonist (IC50: 21 nM). RORγt inverse agonist 29 can be used in the research of skin inflammation and autoimmune diseases like psoriasis .
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-
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- HY-135280
-
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CB1 Inverse agonist 1
|
Cannabinoid Receptor
|
Metabolic Disease
|
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MRL-650 (CB1 inverse agonist 1) is a highly potent, orally active, and specific inverse agonist of CB1 receptor with IC50s of 7.5 nM and 4100 nM for CB1 and CB2 receptors, respectively. Anorexigenic effects .
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-
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- HY-147533
-
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ROR
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Inflammation/Immunology
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RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders .
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-
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- HY-149833
-
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Estrogen Receptor/ERR
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Infection
Metabolic Disease
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ERRγ inverse agonist 2 (compound 19) is a potent and selective ERRγ inverse agonist with a Kd value of 6.5 μM. ERRγ inverse agonist 2 inhibits the expression of hepcidin, fibrinogen and gluconeogenic genes. ERRγ inverse agonist 2 has antimicrobial, anti-coagulant and antidiabetic activities .
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-
-
- HY-111748
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-
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- HY-132195
-
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ROR
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Inflammation/Immunology
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RORγt inverse agonist 14 (8e) is a potent, orally active and selective RORγt inverse agonist (EC50 of 2.5 nM) with anti-inflammatory activity. RORγt inverse agonist 14 is used in the study for rheumatoid arthritis and psoriasis .
|
-
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- HY-139847
-
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ROR
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Inflammation/Immunology
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RORγt inverse agonist 23 is a potent, selective, and orally available novel retinoic acid receptor-related orphan receptor γt inverse agonist.
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-
-
- HY-156354
-
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Others
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Metabolic Disease
|
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GPR61 Inverse agonist 1 (Compound 1) is a GPR61 inverse agonist (IC50: 11 nM). GPR61 Inverse agonist 1 can be used for research of disorders of metabolism and body weight, such as obesity and cachexia .
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-
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- HY-12095
-
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Cannabinoid Receptor
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Neurological Disease
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CB1 inverse agonist 2 is an orally active inverse agonist of Cannabinoid Receptor CB1. CB1 inverse agonist 2 effectively inhibits CP55940-induced hypothermia and anorexia in mice model .
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-
-
- HY-130243
-
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ROR
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Inflammation/Immunology
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RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo .
|
-
-
- HY-114411
-
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Estrogen Receptor/ERR
|
Cancer
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ERRγ Inverse Agonist 1 (Compound 12) is a potent, selective and orally bioavailable Estrogen-related Receptor grammar (ERRγ) inverse agonist, with an IC50 of 40 nM .
|
-
-
- HY-155548
-
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ROR
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Inflammation/Immunology
|
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RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC50 of 0.428 μM. RORγt inverse agonist 31 can alleviate the severity of Imiquimod (HY-B0180)-induced psoriasis in mice .
|
-
-
- HY-131338
-
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ROR
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Inflammation/Immunology
|
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RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved agent-like properties, with an IC50 of 63.8 nM .
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-
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- HY-142806
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ROR
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Inflammation/Immunology
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RORγt inverse agonist 26 is a potent reverse agonist of RORγt. RORγt inverse agonist 26 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 26 has the potential for the research of inflammation and autoimmune diseases (extracted from patent WO2021228215A1, compound 1) .
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-
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- HY-142703
-
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ROR
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Inflammation/Immunology
|
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RORγt inverse agonist 28 is a potent reverse agonist of RORγt. RORγt inverse agonist 28 regulates the differentiation of Th17 cells and inhibits the production of IL-17. RORγt inverse agonist 28 has the potential for the research of inflammation and autoimmune diseases (extracted from patent WO2021228215A1, compound 6) .
|
-
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- HY-128573
-
|
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ROR
|
Neurological Disease
|
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RORγt Inverse agonist 3 is a potent, selective and orally active RORγ inverse agonist, with EC50s of 0.22 μM and 0.15 μM for hRORγ and RORγt (human IL-17 cells), respectively .
|
-
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- HY-133552
-
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ROR
|
Inflammation/Immunology
|
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RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC50 of 51 nM. RORγt is a major transcription factor of genes related to psoriasis pathogenesis such as IL-17A, IL-22, and IL-23R
|
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- HY-118336
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-
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- HY-124225
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-
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- HY-160039
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LXR
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Cancer
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GAC0001E5 is an LXR inverse agonist. GAC0001E5 has antiproliferative activity and can be used in cancer research .
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-
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- HY-169001
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5-HT Receptor
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Neurological Disease
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5-HT2A/5-HT2C inverse agonist 1 is a potent and dual 5-HT2A and 5-HT2C receptor inverse agonist with a hERG inhibitions, thus avoiding cardiovascular risks. 5-HT2A/5-HT2C inverse agonist 1 shows significant antipsychotic efficacy in the MK-801 (HY-15084B)-induced mouse model. 5-HT2A/5-HT2C inverse agonist 1 is promising for research of psychosis .
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- HY-160161
-
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PPAR
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Cancer
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BAY-5094 is a PPAR gamma (PPARG) inverse agonist. BAY-5094 has oral activity. BAY-5094 can be used in the research of luminal bladder cancer .
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- HY-137434
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ABBV-157
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ROR
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Inflammation/Immunology
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Cedirogant (ABBV-157) is an orally active RORγt inverse agonist. Cedirogant can be used for psoriasis research .
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-
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- HY-119010
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-
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- HY-14289
-
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SKF-92334
|
Histamine Receptor
Bacterial
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Cardiovascular Disease
Endocrinology
Cancer
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Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine has anti-cancer and anti-inflammatory activity .
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- HY-14289R
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Histamine Receptor
Bacterial
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Endocrinology
Cancer
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Cimetidine (Standard) is the analytical standard of Cimetidine. This product is intended for research and analytical applications. Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine has anti-cancer and anti-inflammatory activity .
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-
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- HY-137061
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-
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- HY-P1432
-
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GHSR
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Metabolic Disease
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K-(D-1-Nal)-FwLL-NH2 is a high affinity, potent and inverse ghrelin receptor agonist (EC50=3.4 nM, Ki=4.9 nM). K-(D-1-Nal)-FwLL-NH2 can be used for the research of obesity .
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-
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- HY-111273
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-
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- HY-19770
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ROR
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Inflammation/Immunology
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GSK2981278 is a potent and selective RORγ inverse agonist. GSK2981278 inhibits activation of the il17 promoter and interferes RORγ-DNA binding .
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-
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- HY-144699
-
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Estrogen Receptor/ERR
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Cancer
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ERRα antagonist-2 (Compound 11) is a potential ERRα (estrogen related receptor α) inverse agonist with an IC50 of 0.80 μM. ERRα antagonist-2 suppresses the migration and invasion of the ER-negative MDA-MB-231 cell line. ERRα antagonist-2 inhibits breast cancer growth in vivo .
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-
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- HY-133128
-
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ROR
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Cancer
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FM26 (compound 25) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM. FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells .
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-
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- HY-100369A
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GABA Receptor
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Neurological Disease
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DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with Kis of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 ?receptors, respectively .
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- HY-119464
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MRL-871
1 Publications Verification
|
ROR
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Cancer
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MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells .
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- HY-108529
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BMS493
5 Publications Verification
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RAR/RXR
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Metabolic Disease
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BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with RARs. BMS493 also could prevent retinoic acid-induced differentiation . BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-116247
-
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PPAR
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Metabolic Disease
Inflammation/Immunology
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ST247 a potent PPARβ/δ inverse agonist. ST247 has a higher affinity to PPARβ/δ. ST247 modulates expression of the activation marker CCL2 in the opposite direction. ST247 efficiently induces the interaction with corepressors. ST247 inhibits the agonist-induced transcriptional activity of PPARβ/δ .
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- HY-121852
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SCH-225336
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Cannabinoid Receptor
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Inflammation/Immunology
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SCH 336 is a potent, selective, inverse and orally active CB2 agonist. SCH 336 inhibits BaF3/CB2 migration. SCH 336 significantly inhibits the migration of leukocytes in vivo. SCH 336 blocks ovalbumin-induced lung eosinophilia in mice .
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- HY-110329
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Others
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Cancer
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ML179 (SR-1309) is a inverse LRH1 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer .
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- HY-100991
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ZK 39106; LSU-65
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GABA Receptor
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Neurological Disease
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FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of?β-adrenoceptors in mouse cerebral cortex .
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- HY-101198
-
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Histamine Receptor
Apoptosis
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Neurological Disease
Cancer
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Clobenpropit dihydrobromide is a potent histamine H3R antagonist/inverse agonist with a pEC50 of 8.07 for histamine H3LR . Clobenpropit dihydrobromide acts as partial agonist at histamine H4 receptors (Ki 13 nM). Clobenpropit dihydrobromide also binds to serotonin 5-HT3 receptors (Ki 7.4 nM) and α2A/α2C adrenoceptors (Ki 17.4/7.8 nM) . Clobenpropit dihydrobromide increases apoptosis .
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- HY-116603
-
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5-HT Receptor
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Others
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SB-236057 is an inverse agonist of the 5-HT1B receptor that exhibits strong skeletal teratogenicity in rodents and rabbits. SB-236057 affects gene expression during embryonic development through interference with the Notch signaling pathway and interaction with r-esp1. SB-236057 induces somatic patterning and tail extension defects in rat embryos during early organogenesis .
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- HY-110186
-
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Adenosine Receptor
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Metabolic Disease
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PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a Ki value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (Ki=208 nM) and >1,000-fold selectivity over hA3 receptor (Ki >100 μM). PQ-69 can be used for the research of renal dysfunction .
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- HY-103476
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GABA Receptor
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Neurological Disease
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Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR) . Ro15-4513 is a potent ethanol antagonist . Ro15-4513 has anti-anxiety effect . Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-10559
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APD125
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5-HT Receptor
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Neurological Disease
Cancer
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Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.
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-
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- HY-116521
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-
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- HY-B0188
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- HY-12664
-
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Others
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Others
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AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.
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- HY-119208
-
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CXCR
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Others
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VUF11211 is an allosteric inverse CXCR3 agonist with a Kd of 0.65 nM .
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- HY-14289S
-
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SKF-92334-d3
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Histamine Receptor
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Endocrinology
Cancer
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Cimetidine-d3 is the deuterium labeled Cimetidine. Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is an inverse agonist. Cimetidine has anti-cancer and anti-inflammatory activity[1][2][5].
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- HY-16972
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SR9243
5 Publications Verification
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LXR
|
Cancer
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SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction.
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- HY-102075A
-
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- HY-115777
-
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ROR
|
Neurological Disease
|
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ARN-6039 is an orally available inverse agonist of RORγ for autoimmune demyelinating disease.
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- HY-B0188A
-
-
- HY-13421
-
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- HY-159831
-
-
- HY-16998
-
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ROR
|
Inflammation/Immunology
|
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SR2211 is a potent, selective synthetic RORγ modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM.
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- HY-148352
-
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PPAR
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Cancer
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BAY-4931 is a potent, covalent and selective PPARγ inverse-agonist with an IC50 of 0.17 nM .
|
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- HY-14413
-
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ML 176
|
ROR
|
Metabolic Disease
|
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SR3335 (ML 176) is a selective RORα inverse agonist that directly binds to RORα with a Ki of 220 nM .
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- HY-12584
-
-
- HY-114025
-
-
- HY-148237
-
-
- HY-12199
-
-
- HY-12199B
-
-
- HY-103225
-
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SB-737552 phosphate
|
GABA Receptor
|
Neurological Disease
|
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S-8510 (phosphate) is an inverse Benzodiazepine (BDZ) receptor agonist, with Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively.
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- HY-100328
-
-
- HY-128604
-
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ROR
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Cancer
|
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XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC50 of 30 nM and a Kd of 380 nM .
|
-
- HY-12199A
-
-
- HY-14426
-
-
- HY-101192
-
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EBI2/GPR183
|
Inflammation/Immunology
|
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GSK682753A is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM.
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- HY-102075B
-
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ROR
|
Inflammation/Immunology
|
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TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. RORγt is a tractable agent target for the treatment of cutaneous inflammatory disorders .
|
-
- HY-103325
-
-
- HY-116622
-
-
- HY-160160
-
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PPAR
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Cancer
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BAY-5516 is a inverse-agonist o PPARG, with the IC50 value of 6.1±3.6 nM that has anti-tumor effect .
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-
- HY-114685
-
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SB-737552 free base
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GABA Receptor
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Neurological Disease
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S-8510 free base is an inverse Benzodiazepine (BDZ) receptor agonist, with Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively.
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-
- HY-113730
-
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Others
|
Others
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VUF5834 is a non-peptide chemokine receptor CXCR3 antagonist with non-competitive antagonistic and inverse agonistic activities. VUF5834 blocks the effects of CXCL10 and CXCL11 on human CXCR3, exhibits non-competitive antagonistic and inverse agonistic properties to CXCR3, and, except for TAK-779, has a slightly lower affinity for rodent CXCR3 than for primate CXCR3.
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-
- HY-14557
-
-
- HY-101442
-
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LXR
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Metabolic Disease
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SR9238 is a synthetic liver X receptor (LXR) inverse agonist with IC50s of 214 nM and 43 nM for LXRα and LXRβ, respectively.
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-
- HY-143259
-
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LXR
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Cancer
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BE1218 is a liver X receptor (LXR) inverse agonist with IC50 values of 9 nM and 7 nM against LXRα and LXRβ, respectively .
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-
- HY-103500
-
-
- HY-14557A
-
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ACP-103 hemitartrate
|
5-HT Receptor
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Neurological Disease
|
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Pimavanserin (ACP-103) hemitartrate is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.
|
-
- HY-B0188AS
-
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Org GB 94-d3
|
Histamine Receptor
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Neurological Disease
Endocrinology
|
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Mianserin-d3 (hydrochloride) is the deuterium labeled Mianserin hydrochloride. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.
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- HY-135717
-
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Others
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Cancer
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Norbiotinamine is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction .
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- HY-135717A
-
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Others
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Cancer
|
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Norbiotinamine hydrochloride is an alternative to biotin. Norbiotinamine can be coupled with a carboxylic group of amino acids to give inverse peptides, having the amide linkage oriented in the opposite direction .
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-
- HY-147400
-
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KW-6356
|
Adenosine Receptor
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Neurological Disease
|
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Sipagladenant (Compound I) is an orally active adenosine receptor A2A inverse agonist . Sipagladenant can be used in frontal lobe dysfunction research .
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- HY-153344
-
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PPAR
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Cancer
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FX-909 is a covalent peroxisome proliferator-activated receptor gamma (PPARG) inverse agonist. FX-909 can be used for the research of cancer .
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- HY-150308
-
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PPAR
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Cancer
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SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines .
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-
- HY-10013B
-
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MK0364 (1R,2R)stereoisomer
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Cannabinoid Receptor
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Others
|
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Taranabant (1R,2R)stereoisomer is the R-enantiomer of Taranabant. Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist.
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- HY-10013A
-
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MK-0364 racemate
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Cannabinoid Receptor
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Neurological Disease
|
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Taranabant racemate (MK-0364 racemate) is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor extracted from patent WO 2004048317 A1 .
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-
- HY-112219A
-
-
- HY-18286
-
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TSH Receptor
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Endocrinology
|
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NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR). NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously expressed in Graves' disease .
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-
- HY-160188
-
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PPAR
|
Cancer
|
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BAY-9683 is an orally active covalent PPARG inverse agonist. BAY-9683 can be used in the study of diseases with overactive PPARG, such as luminal bladder cancer .
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-
- HY-B0188S
-
-
- HY-119242
-
-
- HY-B0188AR
-
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Histamine Receptor
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Neurological Disease
Endocrinology
|
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Mianserin (hydrochloride) (Standard) is the analytical standard of Mianserin (hydrochloride). This product is intended for research and analytical applications. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.
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-
- HY-120384
-
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ROR
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Inflammation/Immunology
|
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AZD-0284 is a selective inverse agonist of the nuclear receptor RORγ. AZD-0284 has the potential for plaque psoriasis vulgaris and respiratory tract disorders treatment .
|
-
- HY-W140282
-
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Angiotensin Receptor
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Cardiovascular Disease
|
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Angiotensin II antipeptide, a peptide, is an inverse agonist of AR1 receptor. Angiotensin II antipeptide is encoded by mRNA, complementary to that encoding Angiotensin II (HY-13948) itself .
|
-
- HY-163612
-
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ROR
Apoptosis
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Cancer
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XY077 (compound 14a) is a RORγ inverse agonist with the IC50 of 0.004 μM. XY077 induces cell apoptosis and shows antiproliferative activity in vivoand in vitro .
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-
- HY-114706
-
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MDL-26479
|
GABA Receptor
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Neurological Disease
|
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Suritozole (MGL-26479) is a cognitive enhancer that acts as a partial inverse agonist of benzodiazepine receptor sites on GABAA ion channel complexes. Suritozole can be used in the study of neurodegenerative diseases .
|
-
- HY-106025
-
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AC-3933
|
GABA Receptor
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Neurological Disease
|
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Radequinil (AC-3933) is a benzodiazepine receptor (BzR) partial inverse agonist. AC-3933 binds to GABA(-) and GABA(+) ligand with Kis of 5.15 and 6.11 nM, respectively .
|
-
- HY-134661A
-
CVN424
1 Publications Verification
|
GPR6
|
Neurological Disease
|
|
CVN424 is an orally active and selective GPR6 inverse agonist with a Ki of 9.4 nM and an EC50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research .
|
-
- HY-103330
-
-
- HY-163611
-
|
|
ROR
|
Cancer
|
|
XY039 (compound 13e) is a RORγ inverse agonist with the IC50 of 0.55 μM. XY039 induces cell apoptosis and shows antiproliferative activity in vivoand in vitro .
|
-
- HY-112219
-
-
- HY-10013
-
|
MK-0364
|
Cannabinoid Receptor
|
Metabolic Disease
|
|
Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding Ki of 0.13 nM for the human CB1R in vitro.
|
-
- HY-135392
-
|
AC-279
|
Drug Metabolite
|
Neurological Disease
|
|
N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
|
-
- HY-100778
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
SMM-189 is a potent and selective cannabinoid receptor 2 (CB2) inverse agonist. SMM-189 plays an important role in neurodegenerative disorders and traumatic brain injury research .
|
-
- HY-U00443
-
|
|
5-HT Receptor
|
Neurological Disease
Cancer
|
|
SB 258719 is a selective 5-HT7 receptor antagonist with high affinity (pKi=7.5) for the receptor. SB 258719 can be used for the research of cancer and neurological disease .
|
-
- HY-101232
-
|
ICI 125211
|
Histamine Receptor
|
Cardiovascular Disease
|
|
Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors .
|
-
- HY-103123
-
|
|
5-HT Receptor
|
Neurological Disease
Cancer
|
|
SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist displayed high affnity (pKi=7.5) for the receptor. SB-258719 hydrochloride can be used for the research of cancer and neurological diseases .
|
-
- HY-103510
-
|
|
GABA Receptor
|
Neurological Disease
|
|
TB-21007 is an inverse agonist of α5β3γ2 subunit-containing GABAA receptor with a Ki of 1.6 nM. TB-21007 enhanced spatial memory in rats .
|
-
- HY-117118A
-
-
- HY-101630A
-
|
EGIS-3886 fumarate
|
5-HT Receptor
|
Others
|
|
Deramciclane fumarate is an antagonist of 5-HT Receptor. Deramciclane fumarate is an inverse agonist of 5-HT2C Receptor with an IC50 of 168 nM. Deramciclane fumarate also decreases basal phosphoinositide hydrolysis .
|
-
- HY-P10673
-
|
|
GHSR
|
Metabolic Disease
|
|
KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC50=45.6 nM) .
|
-
- HY-109968A
-
|
CEP-26401 hydrochloride
|
Histamine Receptor
|
Neurological Disease
|
|
Irdabisant (CEP-26401) hydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist with Ki values of 7.2 nM and 2.0 nM for rat H3R and human H3R, respectively. Irdabisant hydrochloride has relatively low inhibitory activity against hERG current with an IC50 of 13.8 μM. Irdabisant hydrochloride has cognition-enhancing and wake-promoting activities in the rat social recognition model. Irdabisant hydrochloride can be used to research schizophrenia or cognitive impairment .
|
-
- HY-109968
-
|
CEP-26401
|
Histamine Receptor
|
Neurological Disease
|
|
Irdabisant (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant histamine H3 receptor (H3R) inverse agonist/inverse agonist with Ki values of 7.2 nM and 2.0 nM for rat H3R and human H3R, respectively. Irdabisant has relatively low inhibitory activity against hERG current with an IC50 of 13.8 μM. Irdabisant has cognition-enhancing and wake-promoting activities in the rat social recognition model. Irdabisant can be used to research schizophrenia or cognitive impairment .
|
-
- HY-110060
-
|
|
Complement System
|
Inflammation/Immunology
|
|
NDT 9513727 is a potent, selective, orally active and competitive inverse agonist of the human C5aR (C5a receptor), with an IC50 of 11.6 nM. NDT 9513727 can be used for the research of human inflammatory diseases .
|
-
- HY-148351
-
|
|
PPAR
|
Cancer
|
|
BAY-0069 is a potent and selective PPARγ inverse agonist with an IC50 value of 6.3 nM and 24 nM for human PPARγ and mouse PPARγ. BAY-0069 can be used to research cancer .
|
-
- HY-157070
-
|
|
Others
|
Others
|
|
SCO-L-Lysine contains a SCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. SCO-L-Lysine can be incorporated into the protein of interest by the tRNAPyl/PylRSAF synthetase .
|
-
- HY-14557R
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
Pimavanserin (Standard) is the analytical standard of Pimavanserin. This product is intended for research and analytical applications. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.
|
-
- HY-19775
-
|
|
ROR
|
Inflammation/Immunology
|
|
GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cell. GNE-6468 exhibits an EC50 of 30 nM for IL-17 PBMC .
|
-
- HY-112706
-
|
|
ROR
|
Inflammation/Immunology
|
|
PF-06747711 is a potent, selective, and orally active retinoic acid receptor-related orphan C2 (RORC2, also known as RORγt) inverse agonist, with an IC50 of 4.1 nM. Anti-skin inflammatory activity .
|
-
- HY-157312
-
|
|
Cannabinoid Receptor
|
Metabolic Disease
|
|
CB1 antagonist 4 is a inverse agonist of cannabinoid receptor 1 (CB1) with an IC50 of 0.4 nM. CB1 antagonist 4 can reduce body weight, improve plasma inflammatory markers and glucose homeostasis .
|
-
- HY-17610
-
|
TS-091
|
Histamine Receptor
|
Neurological Disease
|
|
Enerisant is a potent, highly selective, competitive and orally active histamine H3 receptor antagonist/inverse agonist with IC50s of 2.89 nM and 14.5 nM against human and rat histamine H3 receptors, respectively .
|
-
- HY-103365
-
|
VUF2274 hydrochloride
|
CMV
|
Infection
|
|
BX-513 hydrochloride (VUF 2274 hydrochloride)is a novel inverse agonists acting on human cytomegalovirus (HCMV)-encoded receptor US28 with the IC50 of 4.9 μM. BX-513 hydrochloride can be used for study of viral infection .
|
-
- HY-17043
-
-
- HY-106586
-
|
P-286
|
Biochemical Assay Reagents
|
Others
|
|
Ioxaglic acid (P-286) is negatively charged contrast agent, is useful as an inverse indicator for glycosaminoglycan (GAG) used in computed tomography (CT). Ioxaglic acid can be used for imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content .
|
-
- HY-D1646
-
|
|
Fluorescent Dye
|
Others
|
|
BDP TR methyltetrazine is a BDP dye linker containing a methyltetrazine group. BDP TR methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-153895
-
|
|
Estrogen Receptor/ERR
|
Endocrinology
|
|
SLU-PP-1072 is a dual ERRα/γ inverse agonist, used in Prostate cancer (PCa) research. SLU-PP-1072 disrupts PCa cell metabolism, and induces apoptosis via dysregulating cell cycle .
|
-
- HY-151698B
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(R,E)-TCO-NHS Ester is a Click Amino Acid that can be used to label amine-containing compounds or biomolecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-151698A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(S,E)-TCO-NHS Ester is a Click Amino Acid that can be used to label amine-containing compounds or biomolecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-100775
-
|
Setogepram sodium; PBI-4050 sodium
|
Free Fatty Acid Receptor
GPR84
|
Metabolic Disease
Inflammation/Immunology
|
|
Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84 . Fezagepras sodium decreases renal, liver and pancreatic fibrosis . Fezagepras sodium exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions .
|
-
- HY-100775A
-
|
Setogepram; PBI-4050
|
Free Fatty Acid Receptor
GPR84
|
Metabolic Disease
Inflammation/Immunology
|
|
Fezagepras (Setogepram) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84 . Fezagepras decreases renal, liver and pancreatic fibrosis . Fezagepras exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions .
|
-
- HY-151698
-
|
|
ADC Linker
|
Others
|
|
TCO-NHS Ester axial is a click chemistry reagent that can be used as a building block in amine reactions. TCO-NHS Ester axial contains TCO groups, which can undergo inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-160038
-
|
|
LXR
|
Cancer
|
|
GAC0003A4 is an LXR inverse agonist that inhibits LXR transcriptional activity. GAC0003A4 also efficiently degrades LXRβ protein. GAC0003A4 has the potential to be used in advanced pancreatic cancer and other refractory malignancies .
|
-
- HY-124480
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-141186
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-141165
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136095
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136104
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-Maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-17610A
-
|
TS-091 hydrochloride
|
Histamine Receptor
|
Neurological Disease
|
|
Enerisant (TS-091) hydrochloride is a potent, highly selective, competitive and orally active histamine H3 receptor antagonist/inverse agonist with IC50s of 2.89 nM and 14.5 nM against human and rat histamine H3 receptors, respectively .
|
-
- HY-12199BS
-
|
Ciproxidine-d5 hydrochloride; BF 2649-d5 hydrochloride
|
Histamine Receptor
Isotope-Labeled Compounds
|
Neurological Disease
Endocrinology
|
|
Pitolisant-d5 hydrochloride (Ciproxidine-d5 hydrochloride) is the deuterium labeled Pitolisant hydrochloride (HY-12199B). Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM) .
|
-
- HY-14289A
-
|
SKF-92334 hydrochloride
|
Histamine Receptor
Bacterial
|
Endocrinology
Cancer
|
|
Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity .
|
-
- HY-103331
-
-
- HY-155481
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
CB2 receptor antagonist 3 (compound (S)-1) is an inverse agonist of the cannabinoid receptor CB2R with Kd=39 nM. CB2 receptor antagonist 3 can be used as a tool to synthesize a variety of CB2R probes .
|
-
- HY-128353
-
|
|
ROR
|
Inflammation/Immunology
|
|
ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5 .
|
-
- HY-126908
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130283
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-141186A
-
|
|
PROTAC Linkers
|
Cancer
|
|
(R)-TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . (R)-TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136032
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136033
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136039
-
|
|
ADC Linker
|
Cancer
|
|
TCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-SS-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-130928
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-OPSS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136031
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-SS-Biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-W053709
-
|
(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine; Tetrazine-NH2
|
Biochemical Assay Reagents
|
Cancer
|
|
Tetrazine-Amine is a tetrazine linker that can be used to covalently label live cells through a cycloaddition . Tetrazine-Amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-141161B
-
|
|
ADC Linker
|
Cancer
|
|
(R)-TCO-PEG8-acid is an ADC linker containing 8 PEG units. (R)-TCO-PEG8-acid can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-156304
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-C2-TCO is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2243
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3.5 tetrazineis a Tetrazine modified Cy3.5 fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
|
-
- HY-B0349S
-
-
- HY-116625
-
|
|
GHSR
|
Neurological Disease
|
|
PF-04628935 (compound 10n) is a potent ghrelin receptor inverse agonist, with an IC50 of 4.6 nM. PF-04628935 exhibits oral bioavailability of 43% in rats and shows reasonable penetration into the brain. PF-04628935 can be used for stress and anxiety research .
|
-
- HY-133504
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-Ph-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-P1091
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models .
|
-
- HY-150067
-
|
|
Cannabinoid Receptor
|
Metabolic Disease
|
|
CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC50 value of 4.2 μM and EC50 value of ＞10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity .
|
-
- HY-P3561
-
|
|
Melanocortin Receptor
|
Neurological Disease
|
|
Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake .
|
-
- HY-152851
-
|
IMU-935
|
ROR
|
Others
Cancer
|
|
Izumerogant (IMU-935) is an inverse agonist of retinoid-related orphan receptor-gamma (RORγ). Izumerogant (compound 123) also potently inhibits IL-17A, IL-17F and IFN-γ activity with IC50s <50 nM .
|
-
- HY-141167B
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG4-NHS ester is an ADC linker containing 4 PEG units. (S)-TCO-PEG4-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-141169A
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG8-NHS ester is an ADC linker containing 8 PEG units. (S)-TCO-PEG8-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-141169B
-
|
|
ADC Linker
|
Cancer
|
|
(R)-TCO-PEG8-NHS ester is an ADC linker containing 8 PEG units. (R)-TCO-PEG8-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-157008
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG2-Maleimide is an ADC linker containing 2 PEG units. (S)-TCO-PEG2-Maleimide can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-17043S
-
-
- HY-17043S1
-
-
- HY-140015
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-141286
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG4-methyltetrazine is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-methyltetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-140731
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG-TCO (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG-TCO (MW 5000) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-141285
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG4-tetrazine is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-156313
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG4-NHS is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156475
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG2-COOH is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-COOH can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156476
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG2-NHS is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156477
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG8-NHBoc is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156478
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG4-NHBoc is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156479
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG3-NHBoc is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156490
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG5-NHS is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156491
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG9-NHS is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156492
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG4-COOH is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156493
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG5-COOH is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156494
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG9-COOH is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156495
-
|
|
ADC Linker
|
Cancer
|
|
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-D2142
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG2-TCO is a fluorescent dye that reacts with tetrazines. Cy5-PEG2-TCO contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-P3561A
-
|
|
Melanocortin Receptor
|
Neurological Disease
|
|
Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake .
|
-
- HY-W013854
-
|
3β-Hydroxy-5α-androstane
|
Endogenous Metabolite
|
Others
|
|
5α-Androstan-3β-ol (Androstan), a saturated sterol, is a CAR (constitutive androstane receptor) inverse agonist ligand. 5α-Androstan-3β-ol (Androstan) increases the AmB-channel conductance in a concentration dependent manner .
|
-
- HY-101630
-
|
EGIS-3886
|
5-HT Receptor
|
Neurological Disease
|
|
Deramciclane has a high affinity for 5-HT2A and 5-HT2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT2C receptors without direct stimulatory agonist.
|
-
- HY-124717
-
|
|
Endogenous Metabolite
|
Others
|
|
YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration .
|
-
- HY-151691
-
|
|
ADC Linker
|
Others
|
|
Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures .
|
-
- HY-151755
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-Cy3-Tetrazine is a click chemistry reagent containing an tetrazine group. Sulfo-Cy3-Tetrazine is water soluble cyanine fluorescence dye, which is an inverse electron demand [4+2] cycloaddition that takes place between tetrazine and trans-cyclooctene or other strained olefin.
|
-
- HY-156303
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-PEG2-TCO is a dye derivative of Coumarin (HY-N0709) containing 2 PEG units. Coumarin-PEG2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-156306
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-PEG3-TCO is a dye derivative of Coumarin (HY-N0709) containing 3 PEG units. Coumarin-PEG3-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-156309
-
|
|
Fluorescent Dye
|
Others
|
|
Coumarin-PEG8-tetrazine is a dye derivative of Coumarin (HY-N0709) containing 8 PEG units. Coumarin-PEG8-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-17043R
-
|
|
Dengue virus
Flavivirus
Histamine Receptor
|
Infection
Inflammation/Immunology
Endocrinology
Cancer
|
|
Loratadine (Standard) is the analytical standard of Loratadine. This product is intended for research and analytical applications. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
|
-
- HY-10426
-
|
|
Estrogen Receptor/ERR
Autophagy
|
Cancer
|
|
XCT-790 is a potent and selective inverse agonist for ERRα with an IC50 value of 0.37 μM. XCT-790 induces cell death in chemotherapeutic resistant cancer cells. XCT-790 (Compound 12) is inactive against ERRγ and the estrogen receptors ERα and ERβ .
|
-
- HY-126351
-
|
|
Estrogen Receptor/ERR
|
Cancer
|
|
PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM) .
|
-
- HY-140940
-
|
|
PROTAC Linkers
|
Cancer
|
|
Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Biotin-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133467
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG5-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG5-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133468
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG6-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG6-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133474
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG3-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG3-oxyamine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-133476
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG3-alcohol is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-133478
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG11-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG11-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-133475
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG5-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG5-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-133508
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG4-SSPy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG4-SSPy is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133497
-
|
|
PROTAC Linkers
|
Cancer
|
|
HyNic-PEG2-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . HyNic-PEG2-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-P1090
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models .
|
-
- HY-P1091A
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
Hemopressin TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin TFA exerts antinociceptive action in inflammatory pain models .
|
-
- HY-141167A
-
|
|
PROTAC Linkers
|
Cancer
|
|
TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-139780
-
|
|
ROR
|
Inflammation/Immunology
|
|
JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC50 of 9.6 nM. JNJ-61803534 has anti-inflammatory activity. JNJ-61803534 inhibits IL-17A production in human CD4+ T cells under Th17 differentiation conditions .
|
-
- HY-157003
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG2-NH2 is an ADC Linker containing 2 PEG units. (S)-TCO-PEG2-NH2 can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-157006
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG3-NH2 is an ADC linker containing 3 PEG units. (S)-TCO-PEG3-NH2 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-157007
-
|
|
ADC Linker
|
Cancer
|
|
(S)-TCO-PEG7-NH2 is an ADC linker containing 7 PEG units. (S)-TCO-PEG7-NH2 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-D2118
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2116
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG8-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2117
-
|
|
Fluorescent Dye
|
Others
|
|
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130551
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133477
-
|
|
PROTAC Linkers
|
Cancer
|
|
(S)-TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . (S)-TCO-PEG3-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-P1090A
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
Hemopressin(rat) TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) TFA exerts antinociceptive action in inflammatory pain models .
|
-
- HY-111226
-
GSK5182
2 Publications Verification
|
Estrogen Receptor/ERR
Reactive Oxygen Species
|
Cardiovascular Disease
Cancer
|
|
GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM. GSK5182 does not interact with other nuclear receptors, including ERRα or ERα. GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma (HCC) .
|
-
- HY-138747
-
|
|
PROTAC Linkers
|
Cancer
|
|
Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Bis-sulfone-PEG4-Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-111366
-
|
|
ROR
|
Inflammation/Immunology
|
|
CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC50 of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively. CD12681 decreases the IL-17 inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis .
|
-
- HY-156300
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG4-NH2 is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156301A
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG8-NH2 (hydrochloride) is an ADC Linker containing 2 PEG units. Me-Tet-PEG8-NH2 (hydrochloride) can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-W591272
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG3-NH2 is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-100449A
-
|
|
Prostaglandin Receptor
|
Endocrinology
|
|
(S)-AL 8810 is an 11β-fluoro analog of PGF2α that acts as a potent and selective antagonist at the FP receptor. (S)-AL 8810 is the C-15 epimer of AL 8810, having the
inverse, (S), or "natural" configuration at C-15 relative to AL 8810, which is 15-(R) .
|
-
- HY-120531
-
|
|
Histamine Receptor
|
Neurological Disease
|
|
UR-PI376 is a potent and selective histamine H4 receptor (H4R) agonist with a pEC50 value of 7.47. UR-PI376 shows negligible hH1R and hH2R activities and moderate inverse agonistic activity at the hH3R .
|
-
- HY-103186
-
|
|
Adenosine Receptor
|
Inflammation/Immunology
|
|
MRS-1706 is a potent and selective adenosine A2B receptor inverse agonist. MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1 and A3 receptors respectively. MRS-1706 blocks adenosine-mediated cAMP induction .
|
-
- HY-140141
-
|
|
PROTAC Linkers
|
Cancer
|
|
PC Methyltetrazine-PEG4-NHS carbonate ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . PC Methyltetrazine-PEG4-NHS carbonate ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133460
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-NHCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG3-alcohol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133463
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-Ph-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133465
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133479
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136052
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-PEG4-oxyamine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-oxyamine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136050
-
|
|
ADC Linker
|
Cancer
|
|
TCO-PEG3-Biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-Biotin is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136053
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136056
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-PEG4-oxyamine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-oxyamine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136045
-
|
|
ADC Linker
|
Cancer
|
|
APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130977
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-PEG4-amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136074
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-PEG4-aldehyde is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136077
-
|
|
ADC Linker
|
Cancer
|
|
TCO-PEG3-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136086
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-PEG6-amine (hydrochloride) is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG6-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-148211
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-PEG7-amine hydrochloride is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG7-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2148
-
|
|
Fluorescent Dye
|
Others
|
|
AF 430 tetrazine is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. To achieve specific coupling of dye labels and biomolecules .
|
-
- HY-160258
-
|
GDP-Fucose-Am-Tz
|
Biochemical Assay Reagents
|
Others
|
|
GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. GDP-fucose-Am-Tz and TCO-ssDNA were reacted at a ratio of 1:1 to obtain the final product GDP-fucose-ssDNA .
|
-
- HY-118037
-
|
|
CXCR
|
Inflammation/Immunology
|
|
VUF10132 is a non-peptide CXCR3 receptor antagonist with anti-inflammatory activity, inhibiting diseases such as rheumatoid arthritis, multiple sclerosis, and psoriasis. VUF10132 has high affinity for the human CXCR3 receptor but slightly lower affinity for the murine CXCR3 receptor. Additionally, VUF10132 exhibits inverse agonist properties at the CXCR3 receptor .
|
-
- HY-14289AR
-
|
|
Histamine Receptor
Bacterial
|
Endocrinology
Cancer
|
|
Cimetidine (hydrochloride) (Standard) is the analytical standard of Cimetidine (hydrochloride). This product is intended for research and analytical applications. Cimetidine (SKF-92334) hydrochloride is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine hydrochloride is a gastric acid reducer, and can be used for duodenal and gastric ulcers research. Cimetidine hydrochloride has anti-cancer and anti-inflammatory activity .
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-
- HY-133461
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG6-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-133462
-
|
|
PROTAC Linkers
|
Cancer
|
|
Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136040
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-PEG4-SS-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130945
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-PEG5-SS-amine is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG5-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130947
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-PEG4-SS-Py is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-SS-Py is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130955
-
|
|
ADC Linker
|
Cancer
|
|
Amino-bis-PEG3-TCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-bis-PEG3-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-133432
-
|
|
ADC Linker
|
Cancer
|
|
DBCO-PEG4-SS-TCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG4-SS-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-133466
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-PEG4-SS-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-SS-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136035
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136036
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-111226A
-
|
|
Estrogen Receptor/ERR
Reactive Oxygen Species
|
Cardiovascular Disease
Cancer
|
|
(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM . GSK5182 also induces reactive oxyen species (ROS) generation in hepatocellular carcinoma .
|
-
- HY-133505
-
|
|
PROTAC Linkers
|
Cancer
|
|
Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136078
-
|
|
ADC Linker
|
Cancer
|
|
Tetrazine-diazo-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-diazo-PEG4-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-150028
-
|
|
Cannabinoid Receptor
|
Inflammation/Immunology
|
|
CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand, with Ki values of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a full CB1 agonist and CB2 competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity .
|
-
- HY-120785
-
|
|
ROR
|
Inflammation/Immunology
|
|
SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC50 value of 1 μM. SR1555 not only inhibits TH17 cell development and function but also increases the frequency of T regulatory cells, as well as inhibits the expression of IL-17. SR1555 can be used for researching autoimmune diseases .
|
-
- HY-W012974S
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Amino-2-methylpropanoic acid-d3 is the deuterium labeled 3-Amino-2-methylpropanoic acid[1]. 3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors[2].
|
-
- HY-W053709A
-
|
(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine monohydrochloride; Tetrazine-NH2 monohydrochloride
|
Biochemical Assay Reagents
|
Cancer
|
|
Tetrazine-Amine monohydrochloride is the monohydrochloride form of Tetrazine-Amine (HY-W053709). Tetrazine-amine is a Tetrazine linker that can be used to covalently label living cells by cycloaddition . Tetrazine-Amine (monohydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-135392S
-
|
AC-279-d9 hydrochloride
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
N-Desmethyl Pimavanserin-d9 hydrochloride (AC-279-d9 hydrochloride) is the deuterium labeled N-Desmethyl Pimavanserin (HY-135392). N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively .
|
-
- HY-130934
-
|
|
ADC Linker
|
Cancer
|
|
TCO-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136527
-
|
|
ROR
Interleukin Related
|
Inflammation/Immunology
|
|
BMS-986251 is an orally active and selective RORγt inverse agonist with an EC50 of 12 nM for RORγt GAL4. BMS-986251 inhibits IL-17 with an EC50 of 24 nM in human whole blood assay. BMS-986251 demonstrates robust efficacy in mouse acanthosis and Imiquimod-induced (HY-B0180) models (preclinical models of psoriasis) .
|
-
- HY-151730
-
|
|
ADC Linker
|
Others
|
|
(Me)Tz-butanoic acid is a click chemistry reagent containing an azide. (Me)Tz-butanoic acid is tetrazine linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with dienophiles . (Me)Tz-butanoic acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-155322
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3-PEG2-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-155323
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3-PEG3-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-155324
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3-PEG7-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 7 PEG units. Cy3-PEG7-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-D2143
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG3-TCO is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-TCO utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2134
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG3-Tetrazin is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-Tetrazin contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2144
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG7-TCO is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG7-TCO utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2159
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG8-Tetrazin is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG8-Tetrazin contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-151833
-
|
|
ADC Linker
|
Others
|
|
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-10626
-
T0901317
Maximum Cited Publications
28 Publications Verification
|
LXR
FXR
ROR
Apoptosis
|
Cardiovascular Disease
Metabolic Disease
Cancer
|
|
T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα . T0901317 activates FXR with an EC50 of 5 μM . T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively . T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice .
|
-
- HY-130966
-
|
|
ADC Linker
|
Cancer
|
|
TCO-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-PABC-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136100
-
|
|
ADC Linker
|
Cancer
|
|
TCO-PEG1-Val-Cit-PABC-PNP is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-PABC-PNP is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-P1432A
-
|
|
GHSR
|
Cancer
|
|
K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.
|
-
- HY-153095
-
|
|
GHSR
|
Metabolic Disease
|
|
PF-6870961 is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM .
|
-
- HY-153095A
-
|
|
GHSR
|
Metabolic Disease
|
|
PF-6870961 hydrochloride is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 hydrochloride inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 hydrochloride also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM .
|
-
- HY-156307
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG3-Maleimide is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
|
-
- HY-156308
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG4-Maleimide is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
|
-
- HY-156312
-
|
|
ADC Linker
|
Cancer
|
|
Me-Tet-PEG8-Maleimide is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
|
-
- HY-120785A
-
|
|
ROR
|
Inflammation/Immunology
|
|
SR1555 hydrochloride is the hydrochloride salt form of SR1555 (HY-120785). SR1555 hydrochloride is an inverse agonist for retinoic acid receptor-related orphan nuclear receptor γ (RORγ) with an IC50 of 1 μM. SR1555 hydrochloride inhibits the development and function of pro-inflammatory TH17 cell, increases the frequency of anti-inflammatory T regulatory (Treg) cells. SR1555 hydrochloride can be used for research about autoimmune diseases .
|
-
- HY-140313
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136076
-
|
|
ADC Linker
|
Cancer
|
|
TCO-PEG3-CH2-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-CH2-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-155325
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3-PEG2-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-155326
-
|
|
Fluorescent Dye
|
Others
|
|
Cy3-PEG3-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-D2145
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG2-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 2 PEG units. Cy5-PEG2-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2147
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG7-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG7-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2146
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5-PEG3-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-B0349
-
|
Meclozine dihydrochloride
|
Histamine Receptor
Apoptosis
|
Neurological Disease
Endocrinology
Cancer
|
|
Meclizine (Meclozine) dihydrochloride, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride is an effective anti-motion sickness agent. Meclizine dihydrochloride crosses the blood-brain barrier. Meclizine dihydrochloride can be used for the research of polyQ toxicity disorders, such as Huntington's disease. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR .
|
-
- HY-B0349A
-
|
Meclozine
|
Histamine Receptor
Apoptosis
|
Neurological Disease
Inflammation/Immunology
|
|
Meclizine (Meclozine), an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine is a member of the piperazine class of H1 antagonists. Meclizine is an effective anti-motion sickness agent. Meclizine crosses the blood–brain barrier. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine can be used for the research of polyQ toxicity disorders, such as Huntington's disease .
|
-
- HY-B0349B
-
|
Meclozine dihydrochloride monohydrate
|
Histamine Receptor
Apoptosis
|
Neurological Disease
Inflammation/Immunology
|
|
Meclizine (Meclozine) dihydrochloride monohydrate, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride monohydrate is an effective anti-motion sickness agent. Meclizine dihydrochloride monohydrate crosses the blood-brain barrier. Meclizine dihydrochloride monohydrate is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR. Meclizine dihydrochloride monohydrate can be used for the research of polyQ toxicity disorders, such as Huntington's disease .
|
-
- HY-111509
-
|
|
ROR
|
Inflammation/Immunology
|
|
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC50=1.9 nM, reporter gene IC50=6.1 nM). TAK-828F shows excellent RORγt isoforms selectivity (>5000-fold selectivity against human RORα and RORβ) .
|
-
- HY-126252
-
|
|
ROR
Interleukin Related
|
Inflammation/Immunology
|
|
A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 significantly attenuates IL-23 driven psoriasiform dermatitis and is effective in blocking skin and joint inflammation .
|
-
- HY-107489
-
|
|
GABA Receptor
|
Neurological Disease
|
|
RO 4938581 is a potent and selective GABAA α5 inverse agonist, with a Ki of 4.6 nM for GABAA α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (Ki, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.
|
-
- HY-128656
-
|
|
Histamine Receptor
|
Neurological Disease
Endocrinology
|
|
LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders .
|
-
- HY-141009
-
|
|
PROTAC Linkers
|
Cancer
|
|
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-(Mal-PEG6)-N-bis(PEG7-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-130943
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130953
-
|
|
ADC Linker
|
Cancer
|
|
Mal-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Mal-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130970
-
|
|
ADC Linker
|
Cancer
|
|
Amino-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-U00033
-
|
|
Others
|
Neurological Disease
|
|
Iomazenil is a benzodiazepine receptor antagonist with partial inverse agonist activity. Iomazenil can assess the binding potential of central benzodiazepine receptors in the cerebral cortex and may reflect neuronal function in viable tissue. Iomazenil use is associated with improved cognitive function in adult patients with ischemic cerebral pathology after indirect revascularization surgery. Iomazenil demonstrated restoration of benzodiazepine receptor binding potential in the affected hemisphere after surgery on brain SPECT imaging .
|
-
- HY-101460
-
|
|
PROTACs
Molecular Glues
Epigenetic Reader Domain
|
Cancer
|
|
Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
|
-
- HY-115613
-
ML-180
1 Publications Verification
SR1848
|
Others
|
Cancer
|
|
ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 µM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 µM). ML-180 has the potential for LRH-1-dependent cancers .
|
-
- HY-130974
-
|
|
ADC Linker
|
Cancer
|
|
Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-139859
-
|
|
ADC Linker
|
Cancer
|
|
APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG36-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-120124
-
|
SUVN-G3031
|
Histamine Receptor
|
Neurological Disease
|
|
Samelisant (SUVN-G3031) is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant has a similar binding affinity towards human (hH3R; Ki=8.7 nM) and rat (rH3R;Ki=9.8 nM) H3R indicating no inter-species differences. Samelisant can be used for the research of sleep-related disorders .
|
-
- HY-D1598
-
|
|
Fluorescent Dye
|
Others
|
|
Sulfo-CY3 tetrazine potassium is a sulfo-Cyanine3 derivative that contains methyltetrazine moiety (Ex=548 nm, Em=563 nm). Sulfo-CY3 tetrazine potassium can be used for the labeling of metabolically engineered cell-surface glycoconjugates . Sulfo-CY3 tetrazine (potassium) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-145545
-
|
PE(18:0/22:4); 1-Stearoyl-2-Docosatraenoyl-sn-glycero-3-PE
|
Endogenous Metabolite
|
Metabolic Disease
|
|
1-Stearoyl-2-adrenoyl-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) and adrenic acid (HY-W013215) at the sn-1 and sn-2 positions, respectively. 1-Stearoyl-2-adrenoyl-sn-glycero-3-PE levels are inversely correlated with subject age in mitochondria isolated from human post-mortem hippocampus.
|
-
- HY-32329
-
|
Org-8282
|
5-HT Receptor
Adrenergic Receptor
|
Neurological Disease
|
|
Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.
|
-
- HY-D1071
-
|
|
Fluorescent Dye
|
Others
|
|
DBCO-PEG12-TCO cantains a TCO and a DBCO moiety. TCO group can specifically react with terrahydrazine. DBCO-PEG12-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG12-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-141167
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
(E/Z)-TCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. (E/Z)-TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . (E/Z)-TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-140312
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG12-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG12-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136084
-
|
|
ADC Linker
|
Cancer
|
|
Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-D1557
-
|
|
Fluorescent Dye
|
Others
|
|
Cyanine5.5 tetrazine is a far-infrared luminescent dye. Cyanine5.5 tetrazine is a Cyanine5.5 (HY-D0925A) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cyanine5.5 tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-B0349R
-
|
|
Histamine Receptor
Apoptosis
|
Neurological Disease
Endocrinology
Cancer
|
|
Meclizine (dihydrochloride) (Standard) is the analytical standard of Meclizine (dihydrochloride). This product is intended for research and analytical applications. Meclizine (Meclozine) dihydrochloride, an antihistamine, reversibly inhibits the interaction of histamine at the H1 receptors. Meclizine dihydrochloride is a member of the piperazine class of H1 antagonists. Meclizine dihydrochloride is an effective anti-motion sickness agent. Meclizine dihydrochloride crosses the blood-brain barrier. Meclizine dihydrochloride can be used for the research of polyQ toxicity disorders, such as Huntington's disease. Meclizine dihydrochloride is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR .
|
-
- HY-14546
-
|
OPC-14597
|
5-HT Receptor
Dopamine Receptor
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19 .
|
-
- HY-32329A
-
|
MO-8282
|
5-HT Receptor
|
Neurological Disease
|
|
Setiptiline maleate (MO-8282 maleate) is a serotonin receptor antagonist. Setiptiline maleate is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline maleate acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine .
|
-
- HY-133428
-
|
|
ADC Linker
|
Cancer
|
|
DBCO-PEG3-TCO is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG3-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG3-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-122608
-
|
SUVN-G3031 free base
|
Histamine Receptor
|
Neurological Disease
|
|
Samelisant (SUVN-G3031) free base is a potent and selective histamine H3 receptor (H3R) inverse agonist with good brain penetration and oral bioavailability. Samelisant free base has a similar binding affinity towards human (hH3R; Ki=8.7 nM) and rat (rH3R;Ki=9.8 nM) H3R indicating no inter-species differences. Samelisant free base can be used for the research of sleep-related disorders .
|
-
- HY-14546A
-
|
OPC-14597 monohydrate
|
5-HT Receptor
Dopamine Receptor
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole monohydrate is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19 .
|
-
- HY-148057
-
|
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
TCO-PEG4-VC-PAB-MMAE is a agent-linker conjugate for ADC. TCO-PEG4-VC-PAB-MMAE contains a cleavable ADC linker (TCO-PEG4-VC-PA) and a potent tubulin inhibitor MMAE (HY-15162) . TCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136079
-
|
|
ADC Linker
|
Cancer
|
|
Methyltetrazine-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-hydrazone-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG4-hydrazone-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-138659
-
|
JF646, Tetrazine
|
Fluorescent Dye
|
Others
|
|
Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D1482
-
|
|
Fluorescent Dye
|
Others
|
|
Cy5 Tetrazine is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. Its absorption and emission spactra are almost identical to those of Alexa Fluor 647, CF 647 Dye, or any other Cyanine5 based fluorescent dyes. Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-107513
-
|
|
mGluR
|
Neurological Disease
Cancer
|
|
BAY 36-7620 is a potent and noncompetitive antagonist of mGlu1 Receptor (IC50=0.16 μM) with inverse agonist activity. BAY 36-7620 inhibits tumor growth and prolongs the survival of mice with tumors by inhibiting mGlu1 receptor. BAY 36-7620 suppresses AKT phosphorylation in A549 tumors. BAY 36-762 has neuroprotective effect in acute subdural hematoma rat model.BAY 36-7620 is used in non-small cell lung cancer and breast cancer research .
|
-
- HY-32329S
-
|
|
Isotope-Labeled Compounds
5-HT Receptor
Adrenergic Receptor
|
Neurological Disease
|
|
Setiptiline-d3 is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2].
|
-
- HY-130508
-
|
|
PROTAC Linkers
|
Cancer
|
|
Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
-
- HY-14546R
-
|
OPC-14597 (Standard)
|
5-HT Receptor
Dopamine Receptor
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
Aripiprazole (Standard) is the analytical standard of Aripiprazole. This product is intended for research and analytical applications. Aripiprazole (OPC-14597), an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole can be used for the research of schizophrenia and COVID19 .
|
-
- HY-154802
-
|
|
ADC Linker
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2 . TCO-GK-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-129636
-
|
(E)-GABAB receptor antagonist 1
|
GABA Receptor
ERK
|
Neurological Disease
|
|
CLH304a (compound 14) is a specific and noncompetitive GABAB receptor negative allosteric modulator (NAM). CLH304a decreases GABA-induced IP3 production with an IC50 of 37.9 μM. CLH304a has no effect on other GPCR Class C members such as mGluR1, mGluR2, and mGluR5. CLH304a acts on the heptahelical domain of GB2 subunits and non-competitively inhibits the effect of agonists with inverse agonist properties. CLH304a inhibits Baclofen (HY-B0007)-induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptor .
|
-
- HY-140310
-
|
|
ADC Linker
PROTAC Linkers
|
Cancer
|
|
TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-132225
-
|
|
5-HT Receptor
|
Inflammation/Immunology
|
|
SB 206553 is a 5-HT2C inverse agonist. SB 206553 can attenuate methamphetamine-seeking in rats. SB 206553 has activity for 5-HT2 receptor ligands in HEK-293 or CHO-K1 cells expressing human recombinant 5-HT2 receptors with pKi values of 5.6 nM (5-HT2A), 7.7 nM (5-HT2B) and 7.8 nM (5-HT2C), respectively. SB 206553 can be used for the research of psychostimulant abuse disorders .
|
-
- HY-151769
-
|
|
ADC Linker
|
Others
|
|
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-100370
-
|
|
GABA Receptor
|
Cancer
|
|
MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS.
|
-
- HY-N0049
-
|
|
Parasite
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
|
-
- HY-N0049R
-
|
|
5-HT Receptor
Dopamine Receptor
|
Neurological Disease
|
|
Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
|
-
- HY-W008820R
-
|
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .
In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM .
|
-
- HY-103117
-
|
|
5-HT Receptor
|
Neurological Disease
|
|
S 32212 is an inverse agonist of the serotonin (5-HT) receptor subtypes 5-HT2CINI and 5-HT2CVSV (Kis=6.6 and 8.9 nM, respectively). It is also an antagonist of the 5-HT2A receptor and the α2B-adrenergic receptor (Ki=5.8 nM for both). S 32212 is greater than 70-fold selective for these receptors in a panel of 80 receptors, enzymes, and ion channels. S 32212 reduces binding of GTPγS to Gαq and decreases the activity of phospholipase C (PLC) in HEK293 cells expressing 5-HT2CINI receptors (EC50s=38 and 18.6 nM, respectively) and in CHO cells expressing 5-HT2CVSV receptors (EC50s=38 and 18.6 nM, respectively). S 32212 (2.5 mg/kg) decreases head twitching, penile erections, and drug discrimination induced by 5-HT receptor agonists in mice and rats. It reduces immobility time in the forced swim test and decreases marble burying in mice and rats when administered at doses of 10 and 40 mg/kg, indicating anti-depressant-like and anxiolytic activities.
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-D1646
-
|
|
Fluorescent Dyes/Probes
|
|
BDP TR methyltetrazine is a BDP dye linker containing a methyltetrazine group. BDP TR methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-156304
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-C2-TCO is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2243
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3.5 tetrazineis a Tetrazine modified Cy3.5 fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
|
-
- HY-D2142
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG2-TCO is a fluorescent dye that reacts with tetrazines. Cy5-PEG2-TCO contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-151755
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-Cy3-Tetrazine is a click chemistry reagent containing an tetrazine group. Sulfo-Cy3-Tetrazine is water soluble cyanine fluorescence dye, which is an inverse electron demand [4+2] cycloaddition that takes place between tetrazine and trans-cyclooctene or other strained olefin.
|
-
- HY-156303
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-PEG2-TCO is a dye derivative of Coumarin (HY-N0709) containing 2 PEG units. Coumarin-PEG2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-156306
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-PEG3-TCO is a dye derivative of Coumarin (HY-N0709) containing 3 PEG units. Coumarin-PEG3-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-156309
-
|
|
Fluorescent Dyes/Probes
|
|
Coumarin-PEG8-tetrazine is a dye derivative of Coumarin (HY-N0709) containing 8 PEG units. Coumarin-PEG8-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2118
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2116
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA-PEG8-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2117
-
|
|
Fluorescent Dyes/Probes
|
|
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2148
-
|
|
Fluorescent Dyes/Probes
|
|
AF 430 tetrazine is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. To achieve specific coupling of dye labels and biomolecules .
|
-
- HY-155322
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG2-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-155323
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG3-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-155324
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG7-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 7 PEG units. Cy3-PEG7-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-D2143
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG3-TCO is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-TCO utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2134
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG3-Tetrazin is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-Tetrazin contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D2144
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG7-TCO is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG7-TCO utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2159
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG8-Tetrazin is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG8-Tetrazin contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-155325
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG2-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-155326
-
|
|
Fluorescent Dyes/Probes
|
|
Cy3-PEG3-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-D2145
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG2-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 2 PEG units. Cy5-PEG2-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2147
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG7-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG7-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2146
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5-PEG3-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D1598
-
|
|
Fluorescent Dyes/Probes
|
|
Sulfo-CY3 tetrazine potassium is a sulfo-Cyanine3 derivative that contains methyltetrazine moiety (Ex=548 nm, Em=563 nm). Sulfo-CY3 tetrazine potassium can be used for the labeling of metabolically engineered cell-surface glycoconjugates . Sulfo-CY3 tetrazine (potassium) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D1071
-
|
|
Dyes
|
|
DBCO-PEG12-TCO cantains a TCO and a DBCO moiety. TCO group can specifically react with terrahydrazine. DBCO-PEG12-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG12-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-D1557
-
|
|
Fluorescent Dyes/Probes
|
|
Cyanine5.5 tetrazine is a far-infrared luminescent dye. Cyanine5.5 tetrazine is a Cyanine5.5 (HY-D0925A) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cyanine5.5 tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-138659
-
|
JF646, Tetrazine
|
Fluorescent Dyes/Probes
|
|
Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-D1482
-
|
|
Fluorescent Dyes/Probes
|
|
Cy5 Tetrazine is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. Its absorption and emission spactra are almost identical to those of Alexa Fluor 647, CF 647 Dye, or any other Cyanine5 based fluorescent dyes. Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P1091
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models .
|
-
- HY-P3561A
-
|
|
Melanocortin Receptor
|
Neurological Disease
|
|
Agouti-related Protein (AGRP) (83-132) Amide (human) TFA is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake .
|
-
- HY-P1090
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
Hemopressin(rat) is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) exerts antinociceptive action in inflammatory pain models .
|
-
- HY-P1432
-
|
|
GHSR
|
Metabolic Disease
|
|
K-(D-1-Nal)-FwLL-NH2 is a high affinity, potent and inverse ghrelin receptor agonist (EC50=3.4 nM, Ki=4.9 nM). K-(D-1-Nal)-FwLL-NH2 can be used for the research of obesity .
|
-
- HY-W140282
-
|
|
Angiotensin Receptor
|
Cardiovascular Disease
|
|
Angiotensin II antipeptide, a peptide, is an inverse agonist of AR1 receptor. Angiotensin II antipeptide is encoded by mRNA, complementary to that encoding Angiotensin II (HY-13948) itself .
|
-
- HY-P10673
-
|
|
GHSR
|
Metabolic Disease
|
|
KwFwLL-NH2, a hexapeptide, is a ghrelin receptor ligand. KwFwLL-NH2 can act as a specific inverse agonist at the ghrelin receptor but with moderate potency (EC50=45.6 nM) .
|
-
- HY-P3561
-
|
|
Melanocortin Receptor
|
Neurological Disease
|
|
Agouti-related Protein (AGRP) (83-132) Amide (human) is a fragment of agouti-related protein (AGRP) which is a protein found in abundance in the arcuate nucleus of the hypothalamus. AgRP primarily acts as an inverse agonist for the melanocortin-4 receptor (MC4R) to increase food intake .
|
-
- HY-P1091A
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
Hemopressin TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin TFA exerts antinociceptive action in inflammatory pain models .
|
-
- HY-P1090A
-
|
|
Cannabinoid Receptor
|
Neurological Disease
|
|
Hemopressin(rat) TFA is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin(rat) TFA is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin(rat) TFA exerts antinociceptive action in inflammatory pain models .
|
-
- HY-P1432A
-
|
|
GHSR
|
Cancer
|
|
K-(D-1-Nal)-FwLL-NH2 TFA is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). K-(D-1-Nal)-FwLL-NH2 blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-B0188A
-
-
-
- HY-124717
-
-
-
- HY-N0049
-
-
-
- HY-B0188AR
-
-
-
- HY-N0049R
-
|
|
Structural Classification
Alkaloids
other families
Source classification
Plants
|
5-HT Receptor
Dopamine Receptor
|
|
Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
|
-
-
- HY-W008820R
-
|
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
Disease markers
Endocrine diseases
Nervous System Disorder
Endogenous metabolite
|
Endogenous Metabolite
|
|
Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .
In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM .
|
-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-17043S1
-
|
|
|
Loratadine-d5 is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
|
-
-
- HY-W012974S
-
|
|
|
3-Amino-2-methylpropanoic acid-d3 is the deuterium labeled 3-Amino-2-methylpropanoic acid[1]. 3-Amino-2-methylpropanoic acid could induce browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors[2].
|
-
-
- HY-14289S
-
|
|
|
Cimetidine-d3 is the deuterium labeled Cimetidine. Cimetidine (SKF-92334) is an orally active and inverse histamine H2 receptor antagonist with a Ki of 0.6 μM. Cimetidine is an inverse agonist. Cimetidine has anti-cancer and anti-inflammatory activity[1][2][5].
|
-
-
- HY-B0188AS
-
|
|
|
Mianserin-d3 (hydrochloride) is the deuterium labeled Mianserin hydrochloride. Mianserin hydrochloride (Org GB 94) is a H1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant.
|
-
-
- HY-B0188S
-
|
|
|
Mianserin-d3 is the deuterium labeled Mianserin (HY-B0188). Mianserin? is a Histamine 1 receptor inverse agonist and is a psychoactive agent of the tetracyclic antidepressant .
|
-
-
- HY-12199BS
-
|
|
|
Pitolisant-d5 hydrochloride (Ciproxidine-d5 hydrochloride) is the deuterium labeled Pitolisant hydrochloride (HY-12199B). Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM) .
|
-
-
- HY-B0349S
-
|
|
|
Meclizine-d8 is a deuterium labeled Meclizine. Meclizine is a histamine H1 receptor antagonist and has the potential to treat nausea and motion sickness. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for Human CAR[1][2][3].
|
-
-
- HY-17043S
-
|
|
|
Loratadine-d4 is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
|
-
-
- HY-135392S
-
|
|
|
N-Desmethyl Pimavanserin-d9 hydrochloride (AC-279-d9 hydrochloride) is the deuterium labeled N-Desmethyl Pimavanserin (HY-135392). N-Desmethyl Pimavanserin is the active metabolite of Pimavanserin. Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively .
|
-
-
- HY-32329S
-
|
|
|
Setiptiline-d3 is the deuterium labeled Setiptiline. Setiptiline (Org-8282) is a serotonin receptor antagonist. Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine[1][2].
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-103476
-
|
|
|
Azide
|
|
Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR) . Ro15-4513 is a potent ethanol antagonist . Ro15-4513 has anti-anxiety effect . Ro15-4513 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-124480
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-141186
-
|
|
|
PROTAC Synthesis
TCO
|
|
TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-141165
-
|
|
|
PROTAC Synthesis
TCO
|
|
TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136095
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-155481A
-
|
|
|
Azide
|
|
CB2 receptor antagonist 4 (compound (R)-1) is a CB2R-selective inverse agonist with a Kd value of 39 nM .
|
-
- HY-D1646
-
|
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
BDP TR methyltetrazine is a BDP dye linker containing a methyltetrazine group. BDP TR methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-151698B
-
|
|
|
TCO
|
|
(R,E)-TCO-NHS Ester is a Click Amino Acid that can be used to label amine-containing compounds or biomolecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-151698A
-
|
|
|
TCO
|
|
(S,E)-TCO-NHS Ester is a Click Amino Acid that can be used to label amine-containing compounds or biomolecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-151698
-
|
|
|
TCO
|
|
TCO-NHS Ester axial is a click chemistry reagent that can be used as a building block in amine reactions. TCO-NHS Ester axial contains TCO groups, which can undergo inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136104
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-Maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-24592
-
|
|
|
TCO
|
|
(S,E)-Cyclooct-2-enol is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. TCO-NHS ester contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-W784030A
-
|
|
|
TCO
|
|
(S,E)-N-TCO-L-lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. (S,E)-N-TCO-L-lysine contains a TCO group and can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-W784030B
-
|
|
|
TCO
|
|
(R,E)-N-TCO-L-lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. (R,E)-N-TCO-L-lysine contains a TCO group and can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-155481
-
|
|
|
Azide
|
|
CB2 receptor antagonist 3 (compound (S)-1) is an inverse agonist of the cannabinoid receptor CB2R with Kd=39 nM. CB2 receptor antagonist 3 can be used as a tool to synthesize a variety of CB2R probes .
|
-
- HY-126908
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-130283
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-141186A
-
|
|
|
TCO
PROTAC Synthesis
|
|
(R)-TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . (R)-TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-136032
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136033
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Methyltetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136039
-
|
|
|
ADC Synthesis
TCO
|
|
TCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-SS-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-130928
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-Ph-OPSS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-OPSS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-136031
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-SS-Biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-W053709
-
|
(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine; Tetrazine-NH2
|
|
Tetrazine
|
|
Tetrazine-Amine is a tetrazine linker that can be used to covalently label live cells through a cycloaddition . Tetrazine-Amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-141161B
-
|
|
|
TCO
|
|
(R)-TCO-PEG8-acid is an ADC linker containing 8 PEG units. (R)-TCO-PEG8-acid can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-156304
-
|
|
|
TCO
Labeling and Fluorescence Imaging
|
|
Coumarin-C2-TCO is a dye derivative of Coumarin (HY-N0709). Coumarin-C2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
-
- HY-D2243
-
|
|
|
Tetrazine
|
|
Cy3.5 tetrazineis a Tetrazine modified Cy3.5 fluorescent dye. SiR-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
|
-
- HY-133504
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-Ph-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-Ph-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-141167B
-
|
|
|
ADC Synthesis
TCO
|
|
(S)-TCO-PEG4-NHS ester is an ADC linker containing 4 PEG units. (S)-TCO-PEG4-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-141169A
-
|
|
|
TCO
|
|
(S)-TCO-PEG8-NHS ester is an ADC linker containing 8 PEG units. (S)-TCO-PEG8-NHS ester can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-157008
-
|
|
|
TCO
|
|
(S)-TCO-PEG2-Maleimide is an ADC linker containing 2 PEG units. (S)-TCO-PEG2-Maleimide can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
-
- HY-140015
-
|
|
|
TCO
PROTAC Synthesis
|
|
TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-141286
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
TAMRA-PEG4-methyltetrazine is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-methyltetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-140731
-
|
|
|
TCO
PROTAC Synthesis
|
|
TCO-PEG-TCO (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG-TCO (MW 5000) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
-
- HY-141285
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
TAMRA-PEG4-tetrazine is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG4-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
-
- HY-156313
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG4-NHS is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156475
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG2-COOH is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-COOH can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156476
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG2-NHS is an ADC Linker containing 2 PEG units. Me-Tet-PEG2-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156477
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG8-NHBoc is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156478
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG4-NHBoc is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156479
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG3-NHBoc is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NHBoc can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156490
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG5-NHS is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156491
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG9-NHS is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-NHS can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156492
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG4-COOH is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156493
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG5-COOH is an ADC Linker containing 5 PEG units. Me-Tet-PEG5-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156494
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG9-COOH is an ADC Linker containing 9 PEG units. Me-Tet-PEG9-COOH can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-156495
-
|
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
Biotin-PEG3-Me-Tet is an ADC Linker containing 3 PEG units. Biotin-PEG3-Me-Tet can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
-
- HY-D2142
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy5-PEG2-TCO is a fluorescent dye that reacts with tetrazines. Cy5-PEG2-TCO contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing a Tetrazine group.
|
-
- HY-151691
-
|
|
|
Tetrazine
|
|
Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent containing an methyltetrazine group. Methyltetrazine-activated Cy3 probe reacts with TCO-containing compounds via an Inverse-Electron-Demand Diels-Alder reaction to form a stable covalent bond and does not require Cu-catalyst or elevated temperatures .
|
-
- HY-156303
-
|
|
|
TCO
Labeling and Fluorescence Imaging
|
|
Coumarin-PEG2-TCO is a dye derivative of Coumarin (HY-N0709) containing 2 PEG units. Coumarin-PEG2-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
- HY-156306
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Coumarin-PEG3-TCO is a dye derivative of Coumarin (HY-N0709) containing 3 PEG units. Coumarin-PEG3-TCO utilizes its TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
- HY-156309
-
|
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
Coumarin-PEG8-tetrazine is a dye derivative of Coumarin (HY-N0709) containing 8 PEG units. Coumarin-PEG8-tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-140940
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Biotin-PEG4-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Biotin-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133467
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Methyltetrazine-PEG5-methyltetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG5-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133468
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Methyltetrazine-PEG6-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG6-maleimide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133474
-
|
|
|
PROTAC Synthesis
TCO
|
|
TCO-PEG3-oxyamine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG3-oxyamine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-133476
-
|
|
|
PROTAC Synthesis
TCO
|
|
TCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG3-alcohol is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-133478
-
|
|
|
TCO
PROTAC Synthesis
|
|
TCO-PEG11-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG11-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-133475
-
|
|
|
TCO
PROTAC Synthesis
|
|
TCO-PEG5-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG5-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-133508
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Methyltetrazine-PEG4-SSPy is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG4-SSPy is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133497
-
|
|
|
TCO
PROTAC Synthesis
|
|
HyNic-PEG2-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . HyNic-PEG2-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-141167A
-
|
|
|
TCO
PROTAC Synthesis
|
|
TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-157003
-
|
|
|
TCO
|
|
(S)-TCO-PEG2-NH2 is an ADC Linker containing 2 PEG units. (S)-TCO-PEG2-NH2 can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-157006
-
|
|
|
TCO
|
|
(S)-TCO-PEG3-NH2 is an ADC linker containing 3 PEG units. (S)-TCO-PEG3-NH2 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-157007
-
|
|
|
TCO
|
|
(S)-TCO-PEG7-NH2 is an ADC linker containing 7 PEG units. (S)-TCO-PEG7-NH2 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-D2118
-
|
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
TAMRA-PEG3-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-D2116
-
|
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
TAMRA-PEG8-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 8 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-D2117
-
|
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
TAMRA-PEG4-Me-Tet is a dye derivative of TAMRA (HY-135640) containing 4 PEG units. TAMRA-PEG8-Me-Tet contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-130551
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133477
-
|
|
|
TCO
PROTAC Synthesis
|
|
(S)-TCO-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . (S)-TCO-PEG3-maleimide is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-138747
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Bis-sulfone-PEG4-Tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Bis-sulfone-PEG4-Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-156300
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG4-NH2 is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-156301A
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG8-NH2 (hydrochloride) is an ADC Linker containing 2 PEG units. Me-Tet-PEG8-NH2 (hydrochloride) can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-W591272
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG3-NH2 is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-NH2 can use its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups.
|
- HY-140141
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
PC Methyltetrazine-PEG4-NHS carbonate ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . PC Methyltetrazine-PEG4-NHS carbonate ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133460
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-NHCO-PEG3-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG3-alcohol is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133463
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG5-Ph-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133465
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-PEG4-Ph-aldehyde is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-PEG4-Ph-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133479
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136052
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-PEG4-oxyamine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-oxyamine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136050
-
|
|
|
ADC Synthesis
TCO
|
|
TCO-PEG3-Biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-Biotin is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-136053
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Tetrazine-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136056
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-PEG4-oxyamine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-oxyamine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136045
-
|
|
|
Tetrazine
ADC Synthesis
|
|
APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG4-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-130977
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-PEG4-amine (hydrochloride) is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136074
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-PEG4-aldehyde is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-aldehyde is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136077
-
|
|
|
TCO
ADC Synthesis
|
|
TCO-PEG3-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-136086
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-PEG6-amine (hydrochloride) is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG6-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-148211
-
|
|
|
Tetrazine
|
|
Tetrazine-PEG7-amine hydrochloride is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG7-amine (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-D2148
-
|
|
|
Tetrazine
|
|
AF 430 tetrazine is a derivative of the yellow fluorescent dye AF 430. AF430 has an excitation wavelength of 425 nm and an emission wavelength of 542 nm. AF 430 tetrazine contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. To achieve specific coupling of dye labels and biomolecules .
|
- HY-160258
-
|
GDP-Fucose-Am-Tz
|
|
Tetrazine
|
|
GDP-Fucose-Tz (GDP-Fucose-Am-Tz) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. GDP-fucose-Am-Tz and TCO-ssDNA were reacted at a ratio of 1:1 to obtain the final product GDP-fucose-ssDNA .
|
- HY-133461
-
|
|
|
Tetrazine
PROTAC Synthesis
|
|
Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG6-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133462
-
|
|
|
PROTAC Synthesis
Tetrazine
|
|
Tetrazine-Ph-NHCO-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Tetrazine-Ph-NHCO-PEG4-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136040
-
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Tetrazine
ADC Synthesis
|
|
Tetrazine-PEG4-SS-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130945
-
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Tetrazine
ADC Synthesis
|
|
Tetrazine-PEG5-SS-amine is a cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG5-SS-amine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130947
-
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|
Tetrazine
ADC Synthesis
|
|
Tetrazine-PEG4-SS-Py is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-PEG4-SS-Py is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-130955
-
|
|
|
ADC Synthesis
TCO
|
|
Amino-bis-PEG3-TCO is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-bis-PEG3-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-133432
-
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|
|
ADC Synthesis
DBCO
TCO
|
|
DBCO-PEG4-SS-TCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG4-SS-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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- HY-133466
-
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|
Tetrazine
ADC Synthesis
|
|
Methyltetrazine-PEG4-SS-NHS ester is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-SS-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136035
-
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|
|
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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- HY-136036
-
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|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-SS-PEG4-Biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-SS-PEG4-Biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133505
-
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Tetrazine
PROTAC Synthesis
|
|
Me-Tet-PEG4-NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Me-Tet-PEG4-NH2 (hydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136078
-
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|
|
Tetrazine
ADC Synthesis
|
|
Tetrazine-diazo-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Tetrazine-diazo-PEG4-biotin is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-W053709A
-
|
(4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine monohydrochloride; Tetrazine-NH2 monohydrochloride
|
|
Tetrazine
|
|
Tetrazine-Amine monohydrochloride is the monohydrochloride form of Tetrazine-Amine (HY-W053709). Tetrazine-amine is a Tetrazine linker that can be used to covalently label living cells by cycloaddition . Tetrazine-Amine (monohydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-130934
-
|
|
|
ADC Synthesis
TCO
|
|
TCO-PEG1-Val-Cit-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-151730
-
|
|
|
Tetrazine
|
|
(Me)Tz-butanoic acid is a click chemistry reagent containing an azide. (Me)Tz-butanoic acid is tetrazine linker for conjugation via Diels-Alder-reaction, i.e. copper-free Click reaction with dienophiles . (Me)Tz-butanoic acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-155322
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy3-PEG2-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-155323
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy3-PEG3-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-155324
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy3-PEG7-TCO is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 7 PEG units. Cy3-PEG7-TCO can use its own TCO group to perform an inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-D2143
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy5-PEG3-TCO is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-TCO utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
- HY-D2134
-
|
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
Cy5-PEG3-Tetrazin is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-Tetrazin contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-D2144
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy5-PEG7-TCO is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG7-TCO utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
- HY-D2159
-
|
|
|
Tetrazine
|
|
Cy5-PEG8-Tetrazin is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG8-Tetrazin contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-151833
-
|
|
|
Tetrazine
|
|
Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent containing an azide group. Methyltetrazine-amido-N-bis(PEG4-acid) is a PEG derivative that contains a methyltetrazine group and two acid groups. This reagent can react with TCO-containing compounds to form a stable covalent bond without the catalysis of Cu or elevated temperatures. The inverse-electron demand Diels-Alder cycloaddition reaction of TCO with tetrazines is the fastest bioorthogonal reaction with exceptional selectivity. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. PEG linker increases the water solubility of the compound. Reagent grade, for research use only . Methyltetrazine-amido-N-bis(PEG4-acid) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-130966
-
|
|
|
ADC Synthesis
TCO
|
|
TCO-PEG1-Val-Cit-PABC-OH is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-PABC-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-136100
-
|
|
|
ADC Synthesis
TCO
|
|
TCO-PEG1-Val-Cit-PABC-PNP is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG1-Val-Cit-PABC-PNP is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-156307
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG3-Maleimide is an ADC Linker containing 3 PEG units. Me-Tet-PEG3-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
|
- HY-156308
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG4-Maleimide is an ADC Linker containing 4 PEG units. Me-Tet-PEG4-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
|
- HY-156312
-
|
|
|
Tetrazine
|
|
Me-Tet-PEG8-Maleimide is an ADC Linker containing 8 PEG units. Me-Tet-PEG8-Maleimide can utilize its own Tetrazine group to undergo a specific inverse electron demand Diels-Alder reaction (iEDDA) with compounds with TCO groups. Its maleimide group (-Maleimide) degrades in aqueous media and has been used in drug delivery studies.
|
- HY-140313
-
|
|
|
ADC Synthesis
Tetrazine
DBCO
|
|
Methyltetrazine-DBCO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136076
-
|
|
|
TCO
ADC Synthesis
|
|
TCO-PEG3-CH2-aldehyde is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG3-CH2-aldehyde is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-155325
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy3-PEG2-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 2 PEG units. Cy3-PEG2-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-155326
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy3-PEG3-TCO4 is a dye derivative of Cyanine 3 (Cy3) (HY-D0822) containing 3 PEG units. Cy3-PEG3-TCO4 can use its own TCO group to perform the inverse electron demand Diels-Alder reaction (iEDDA) with molecules with Tetrazine groups.
|
- HY-D2145
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy5-PEG2-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 2 PEG units. Cy5-PEG2-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
- HY-D2147
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy5-PEG7-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 7 PEG units. Cy5-PEG7-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
- HY-D2146
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
Cy5-PEG3-TCO4 is a dye derivative of Cyanine 5 (Cy5) (HY-D0821) containing 3 PEG units. Cy5-PEG3-TCO4 utilizes its own TCO group to undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules bearing Tetrazine groups.
|
- HY-141009
-
|
|
|
TCO
PROTAC Synthesis
|
|
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . N-(Mal-PEG6)-N-bis(PEG7-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-130943
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-SS-PEG4-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-130953
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Mal-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Mal-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-130970
-
|
|
|
Tetrazine
ADC Synthesis
|
|
Amino-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Amino-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-101460
-
|
|
|
Tetrazine
|
|
Tz-Thalidomide is a tetrazine tagged Thalidomide (HY-14658) (Ligands for E3 Ligase). Tz-Thalidomide has binding affinity for BRD4, with IC50s of 46.25 μM (BRD4-1) and 62.55 μM (BRD4-2). Tz-Thalidomide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups .
|
- HY-130974
-
|
|
|
ADC Synthesis
Tetrazine
|
|
Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Ald-Ph-PEG4-bis-PEG3-methyltetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-139859
-
|
|
|
ADC Synthesis
Tetrazine
|
|
APN-PEG36-tetrazine is an analogue of APN-PEG4-tetrazine. APN-PEG4-tetrazine is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . APN-PEG36-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-D1598
-
|
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
Sulfo-CY3 tetrazine potassium is a sulfo-Cyanine3 derivative that contains methyltetrazine moiety (Ex=548 nm, Em=563 nm). Sulfo-CY3 tetrazine potassium can be used for the labeling of metabolically engineered cell-surface glycoconjugates . Sulfo-CY3 tetrazine (potassium) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-D1071
-
|
|
|
DBCO
|
|
DBCO-PEG12-TCO cantains a TCO and a DBCO moiety. TCO group can specifically react with terrahydrazine. DBCO-PEG12-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG12-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-141167
-
|
|
|
ADC Synthesis
TCO
PROTAC Synthesis
|
|
(E/Z)-TCO-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. (E/Z)-TCO-PEG4-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . (E/Z)-TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-140312
-
|
|
|
Tetrazine
DBCO
PROTAC Synthesis
|
|
Methyltetrazine-PEG12-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-PEG12-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG12-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-136084
-
|
|
|
TCO
ADC Synthesis
|
|
Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Mal-PEG4-(PEG3-DBCO)-(PEG3-TCO) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-D1557
-
|
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
Cyanine5.5 tetrazine is a far-infrared luminescent dye. Cyanine5.5 tetrazine is a Cyanine5.5 (HY-D0925A) derivative contains a tetrazine moiety. Cyanine5.5 tetrazine can be used for in vivo imaging and low background applications. Cyanine5.5 tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-133428
-
|
|
|
TCO
ADC Synthesis
DBCO
|
|
DBCO-PEG3-TCO is a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG3-TCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-PEG3-TCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-148057
-
|
|
|
ADC Synthesis
TCO
|
|
TCO-PEG4-VC-PAB-MMAE is a agent-linker conjugate for ADC. TCO-PEG4-VC-PAB-MMAE contains a cleavable ADC linker (TCO-PEG4-VC-PA) and a potent tubulin inhibitor MMAE (HY-15162) . TCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-136079
-
|
|
|
ADC Synthesis
DBCO
Tetrazine
|
|
Methyltetrazine-PEG4-hydrazone-DBCO is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Methyltetrazine-PEG4-hydrazone-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. Methyltetrazine-PEG4-hydrazone-DBCO also contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-138659
-
|
JF646, Tetrazine
|
|
Labeling and Fluorescence Imaging
Tetrazine
|
|
Janelia Fluor 646, Tetrazine (JF646, Tetrazine) a red fluorescent dye that contains a tetrazine group. JF646, Tetrazine can be used in cellular imaging . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute. Janelia Fluor? 646, Tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-D1482
-
|
|
|
Tetrazine
Labeling and Fluorescence Imaging
|
|
Cy5 Tetrazine is a water-soluble, pH-insensitive from pH 4 to pH 10, far-red-fluorescent probe with excitation ideally suited for the 633 nm or 647 nm laser lines. Its absorption and emission spactra are almost identical to those of Alexa Fluor 647, CF 647 Dye, or any other Cyanine5 based fluorescent dyes. Sulfo-Cy5-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
|
- HY-130508
-
|
|
|
Azide
Tetrazine
PROTAC Synthesis
|
|
Methyltetrazine-Ph-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Methyltetrazine-Ph-PEG4-azide is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
|
- HY-154802
-
|
|
|
TCO
|
|
TCO-GK-PEG4-NHS ester is an ADC Linker, and can be used for synthesis of [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d. [18F]AlF-NOTA-Tz-TCO-GK-2Rs15d binds with high affinity and immunoreactivity to HER2 . TCO-GK-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-140310
-
|
|
|
DBCO
PROTAC Synthesis
ADC Synthesis
TCO
|
|
TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
|
- HY-151769
-
|
|
|
Labeling and Fluorescence Imaging
TCO
|
|
TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent containing an azide group. TCO-PEG2-Sulfo-NHS ester is a PEG linker containing a TCO moiety and a sulfo-NHS ester moiety. The sulfo group makes this molecule soluble in waqueous buffer. This reagent can be used to label antibodies, proteins and other primary amine-containing macromolecules with TCO moiety. Reagent grade, for research use only . TCO-PEG2-Sulfo-NHS ester-EDC Urea is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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