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" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (2) Amyloid-β (2) Antibiotic (2) Apoptosis (22) Autophagy (9) Bacterial (8) Biochemical Assay Reagents (31) Calcium Channel (4) Calmodulin (3) CaMK (3) Carbonic Anhydrase (1) Casein Kinase (1) CD3 (2) Cholinesterase (ChE) (1) Cryptochrome (1) Cytochrome P450 (3) DNA Alkylator/Crosslinker (2) DNA Stain (5) DNA/RNA Synthesis (4) Dopamine Receptor (1) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (7) Epigenetic Reader Domain (1) ERK (1) Ferroptosis (4) FKBP (1) Fluorescent Dye (68) Fungal (2) GLUT (2) HCN Channel (2) HDAC (3) Hedgehog (1) Histone Methyltransferase (2) IKK (1) Integrin (2) Isotope-Labeled Compounds (3) Kinesin (1) mGluR (1) Mitochondrial Metabolism (1) Myosin (8) NAMPT (1) Necroptosis (2) Parasite (6) PD-1/PD-L1 (2) Phosphodiesterase (PDE) (1) Photosystem II (2) PI3K (2) PKA (1) PKC (1) Potassium Channel (6) PROTACs (3) Reactive Oxygen Species (11) ROCK (2) ROS Kinase (1) SARS-CoV (1) Sirtuin (1) Smo (2) SOD (1) Sodium Channel (3) STING (1) TNF Receptor (2) Toll-like Receptor (TLR) (9) Trk Receptor (1) TRP Channel (1) TrxR (1) Wnt (1)
By Research Areas:	Cancer (69) Cardiovascular Disease (10) Endocrinology (1) Infection (15) Inflammation/Immunology (38) Metabolic Disease (7) Neurological Disease (27)
Click Chemistry:	Azide (1) Alkynes (2)
Oligonucleotides:	CpG ODNs (9) mRNA (2)

282

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126367

Light green SF yellowish 1 Publications Verification Acid Green 5	Fluorescent Dye	Others
Light green SF yellowish (Acid Green 5) is a triarylmethane dye. Light green SF yellowish is a highly selective mitochondrial stain. Light green SF yellowish is usually available as a disodium salt and has a maximum absorption value as 629 nm. Light green SF yellowish can be used as a histological stain for collagen and a critical component of Papanicolaou stains .

HY-D1416

HMBR	Fluorescent Dye	Others
HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant .

HY-B1556

Benzyl salicylate NSC 6647	Others	Others
Benzyl salicylate is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber.

HY-P99481

Birtamimab NEOD001	Amyloid-β	Neurological Disease
Birtamimab (NEOD001) is an investigational monoclonal antibody that specifically and selectively target and clear the amyloid. Birtamimab can be used for the research of light chain amyloidosis .

HY-131551

Drometrizole	Biochemical Assay Reagents	Others
Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies .

HY-154636A

Light Liquid Paraffin	Biochemical Assay Reagents	Others
Light Liquid Paraffin can be used as an excipient, such as excipient, lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .

HY-P5998

*Myosin Light* Chain Kinase Substrate (smooth muscle)**	Myosin	Cancer
Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate .

HY-126789

DM-Nitrophen	Others	Others
DM-Nitrophen is a Ca ²⁺ cage. DM-Nitrophen releases Ca ²⁺ when cleaved upon illumination with near-ultraviolet light .

HY-145890

LC kinetic stabilizer-2	Others	Inflammation/Immunology
LC kinetic stabilizer-2 is a potent amyloidogenic immunoglobulin light chain (LC) kinetic stabilizer with an EC₅₀ of 24 nM .

HY-B1556R

Benzyl salicylate (Standard)	Others	Others
Benzyl salicylate (Standard) is the analytical standard of Benzyl salicylate. This product is intended for research and analytical applications. Benzyl salicylate?is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber.

HY-131551R

Drometrizole (Standard)	Biochemical Assay Reagents	Others
Drometrizole (Standard) is the analytical standard of Drometrizole. This product is intended for research and analytical applications. Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies .

HY-126913

Rhodblock 6	ROCK	Cancer
Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits phospho-MRLC (myosin regulatory light chain) localization .

HY-131019

JF-NP-26	mGluR	Neurological Disease
JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm). JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals .

HY-119994

DFPM	Others	Others
DFPM activates plant resistance protein signaling in roots, and triggers root growth arrest. DFPM decreases root cell viability in accession Col-0. DFPM is light sensitive in aqueous solutions. DFPM becomes bioactive during light and oxygen-dependent modification .

HY-B0754

Hematoporphyrin Hematoporphyrin IX	Apoptosis Endogenous Metabolite	Cancer
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-B0754A

Hematoporphyrin dihydrochloride 10+ Cited Publications Hematoporphyrin IX dihydrochloride	Apoptosis Endogenous Metabolite	Cancer
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-161092

KIO-301 chloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium channels during exposure to visible light .

HY-161092A

KIO-301 chloride (hydrochloride)	HCN Channel Potassium Channel	Others
KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels) .

HY-126789A

DM-Nitrophen tertasodium	Others	Others
DM-Nitrophen tertasodium is a Ca ²⁺ cage. DM-Nitrophen releases Ca ²⁺ when cleaved upon illumination with near-ultraviolet light . DM-Nitrophen tertasodium can be used for study of Ca ²⁺ signaling .

HY-161650

PROTAC BRD4 Degrader-26	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC, which degrades 80% BRD4 at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 (HY-161651); Black: linker (HY-161653); Blue: E3 ligase ligand Thalidomide 4-fluoride (HY-41547))

HY-P99810

Quisovalimab AVTX-002; AEVI 002; SAR 252067	SARS-CoV	Cardiovascular Disease
Quisovalimab (AVTX-002; AEVI 002; SAR 252067) is a human monoclonal antibody against *LIGHT*, a tumor necrosis factor (TNF)-related cytokine (TNFSF14) that plays an important role in acute respiratory distress syndrome (ARDS) and cytokine release syndrome (CRS) COVID-19. Quisovalimab can be used in COVID-19 acute respiratory distress syndrome and other studies .

HY-145889

LC kinetic stabilizer-1	Others	Others
LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC₅₀s of 140 and 74.1 nM for WIL-FL ^* and WIL-FL ^* T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer .

HY-116420

ROCK2-IN-8	ROCK	Neurological Disease
ROCK2-IN-8 (Compound 1) is an orally active ROCK2 inhibitor, with an IC₅₀ of 7.2 nM. ROCK2-IN-8 can be used for the research of aqueous humor outflow in porcine eyes and myosin light chain phosphorylation .

HY-P10628

β Amyloid (1-14), human	Amyloid-β	Neurological Disease
β Amyloid (1-14), human is a peptide fragment of β-amyloid protein (Aβ), which is obtained by hydrolysis of Aβ1-40 peptide by catalytic antibody light chain #7TR. β Amyloid (1-14), human can be used for Alzheimer's disease research .

HY-155996

FD2157	PI3K Apoptosis	Cancer
FD2157 is a photosensitive PI3K inhibitor, with IC₅₀s of 43 nM, 83 nM, 84 nM, 14 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ respectively. FD2157 potently inhibits cancer cell proliferation and induces cell apoptosis when exposed to 365 nm UV light .

HY-P990785

ABBV-383 TNB 383B; Etentamig	CD3	Cardiovascular Disease Inflammation/Immunology Cancer
ABBV-383 (ABBV-383) is a BCMA × CD3 bispecific T-cell engager (BiTE) that can inhibit the activity of B-cell maturation antigen (BCMA) and activate the T-cell surface glycoprotein CD3 complex. ABBV-383 can be used for research in multiple myeloma, immunoglobulin light chain amyloidosis, and cardiovascular diseases .

HY-112841

PTZ-343 3-(10′-Phenothiazinyl)propane-1-sulfonate sodium; SPTZ sodium	Others	Cancer
PTZ-343 is a potent enhancer of Luminol (HY-15922). PTZ-343 greatly increases the light output of the peroxidase-catalyzed luminol chemiluminescent oxidation reaction (>80%) .

HY-100912

W-7 hydrochloride 4 Publications Verification	Phosphodiesterase (PDE) Myosin Apoptosis Calmodulin	Cancer
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca ²⁺-calmodulin-dependent phosphodiesterase and *myosin light* chain kinase with IC₅₀ values of 28 μM and 51 μM, respectively . W-7 hydrochloride induces apoptosis** and has antitumor activity .

HY-110211

BODIPY TMR-X SE	Fluorescent Dye	Others
BODIPY TMR-X SE is a potent fluorescent dye. BODIPY TMR-X SE can be used to label the primary amines (R-NH₂) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, orange fluorescent light. (λ_ex=544 nm, λ_em=570 nm) .

HY-D0367

Fluorescent Brightener 28 Calcofluor White M2R	Fluorescent Dye	Others
Fluorescent brightener 28 is a fluorescent whitening agent commonly used in the padding process of the textile industry. Fluorescent brightener 28 is capable of staining polysaccharides such as cellulose, and when the plasma membrane ruptures, it also weakly stains the cytoplasm and strongly stains the cell nucleus. Additionally, Fluorescent brightener 28 can be utilized to detect intracellular chitin in living cells. Fluorescent Brightener 28 also is a visible light emitting diode (LED)-light sensitive photoinitiator for free radical photopolymerizations .

HY-W750459

Fluorescent brightener 28 (Technical Grade)	Fluorescent Dye	Others
Fluorescent brightener 28 (Technical Grade) is a fluorescent whitening agent commonly used in the padding process of the textile industry. Fluorescent brightener 28 is capable of staining polysaccharides such as cellulose, and when the plasma membrane ruptures, it also weakly stains the cytoplasm and strongly stains the cell nucleus. Additionally, Fluorescent brightener 28 can be utilized to detect intracellular chitin in living cells. Fluorescent Brightener 28 also is a visible light emitting diode (LED)-light sensitive photoinitiator for free radical photopolymerizations .

HY-110212

BODIPY TR-X BODIPY TR-X NHS Ester	Fluorescent Dye	Others
BODIPY TR-X (BODIPY TR-X NHS Ester) is a potent fluorescent dye. BODIPY TR-X can be used to label the primary amines (R-NH₂) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, red fluorescent light. (λ_ex=545 nm, λ_em=560 nm) .

HY-124717

YC-001	Endogenous Metabolite	Others
YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration .

HY-100224

SANT-1 2 Publications Verification	Smo Hedgehog	Cancer
SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC₅₀s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively .

HY-P2162

Kemptamide	Myosin	Cancer
Kemptamide, a 13 amino acid fragment with a sequence corresponding to residues 11-23 of gizzard light chain. Kemptamide is a peptide substrate of myosin light-chain kinase (MLCK) .

HY-D0823

CY3-SE Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester	Fluorescent Dye	Others
Storage: protect from light.

HY-D1815

Allophycocyanin 1 Publications Verification APC Dye	Fluorescent Dye	Others
Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .

HY-P99325

Toralizumab IDEC-131; Anti-Human CD40 ligand Recombinant Antibody	TNF Receptor	Inflammation/Immunology
Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab, a immunosuppressive agent, has the potential for active systemic lupus erythematosus (SLE) research .

HY-125667

PA1 Photoamiloride-1	Sodium Channel	Metabolic Disease
PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC₅₀ values of 4.3nM, 90 nM, and 390 nM, respectively .

HY-161093

PROTAC BRD4 Degrader-23	PROTACs	Cancer
PROTAC BRD4 Degrader-23 (compound 17) is an effective visible-light-controlled degrader. PROTAC BRD4 Degrader-23 can inhibit tumor cell proliferation under 405 nm light irradiation .

HY-161897

CENP-E-IN-2	Kinesin	Cancer
CENP-E-IN-2 (compound 3) is a photoswitchable CENP-E inhibitor, with the pIC₅₀ of 6.82 without light illumination and 5.85 with 365 nm light illumination. CENP-E-IN-2 has antitumor activity .

HY-P1004A

Luciferase, firefly	Fluorescent Dye	Others
Luciferase, firefly is the light-emitting enzyme responsible for the bioluminescence of fireflies and click beetles.

HY-131123

N-Nitrosomorpholine	Others	Others
N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen .

HY-112794

Topanol CA	Others	Others
Topanol CA serves as an effective antioxidant and stabilizer for resins and light-colored rubber products.

HY-P990757

Ragistomig	TNF Receptor PD-1/PD-L1	Inflammation/Immunology
Ragistomig is an anti-TNFRSF9/CD274 IgG1 monoclonal antibody composed of a κ light chain and a variable region with a λ light chain and an IgG1 heavy chain. The overall structure is a dimer composed of two identical IgG1 heavy chains .

HY-137477

Spiropyran hexyl methacrylate	Others	Others
Spiropyran hexyl methacrylate is used for spiropyran-based polymeric hydrogel for light-activated mechanical actuation .

HY-D0114

3-Carboxy-7-Hydroxycoumarin	Fluorescent Dye	Others
3-Carboxy-7-Hydroxycoumarin is a UV-light excitable fluorescent dye .

HY-32247

DCAF	Others	Others
DCAF is an electron-deficient azaacene and acts as an electron injection material for organic light-emitting diodes .

HY-W087913

alpha-Naphtholphthalein	Biochemical Assay Reagents	Others
alpha-Naphtholphthalein is an indicator that is light yellow at pH 6 and gradually shows a clear color change with increasing pH to light green-green-blue. alpha-Naphtholphthalein can be impregnated into cotton-blend fabrics and used to develop medical supplies for wound pH monitoring, such as medical gauze, hospital gowns and compression bandages .

HY-161652

Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione is the conjugate of a linker and a ligand for E3 ligase. Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione can be used for synthesis of PROTAC BRD4 Degrader-26 (HY-161650) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1556

Benzyl salicylate NSC 6647	Monophenols Cornaceae Classification of Application Fields Cornus walteri Wangerin Source classification Other Diseases Phenols Plants Disease Research Fields	Others
Benzyl salicylate is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber.

HY-B0754A

Hematoporphyrin dihydrochloride 10+ Cited Publications Hematoporphyrin IX dihydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-124717

YC-001	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration .

HY-113485

Melanin 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation.

HY-N4096

Tsugaric acid A	Triterpenes Structural Classification Human Gut Microbiota Metabolites other families Microorganisms Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields	Others
Tsugaric acid A can significantly inhibit superoxide anion formation. Tsugaric acid A also protects human keratinocytes against damage induced by ultraviolet B (UV B) light. Tsugaric acid A can protect keratinocytes from photodamage.

HY-B1556R

Benzyl salicylate (Standard)	Monophenols Cornaceae Cornus walteri Wangerin Source classification Phenols Plants	Others
Benzyl salicylate (Standard) is the analytical standard of Benzyl salicylate. This product is intended for research and analytical applications. Benzyl salicylate?is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber.

HY-148851

Bacteriochlorophyll a, from Rhodopseudomonas sphaeroides (under argon) BChl a, from Rhodopseudomonas sphaeroides (under argon)	Structural Classification Natural Products Microorganisms Source classification	Others
Bacteriochlorophyll a, from Rhodopseudomonas sphaeroides (under argon) (BChl a, from Rhodopseudomonas sphaeroides (under argon)) is a chlorophyll analog found in some bacteria that participates in the light absorption and energy transfer processes of photosynthesis .

HY-B0754

Hematoporphyrin Hematoporphyrin IX	Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite
Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .

HY-N3491

Isodictamnine	Structural Classification Alkaloids Dictamnus dasycarpus Turcz. Source classification Rutaceae Plants	Others
Isodictamnine is a phototoxic furoquinoline compound of the Turnipaceae family. Isodictamnine is phototoxic to certain bacteria and yeasts under long-wave UV light .

HY-W753500

(E,E)-9,11-Tetradecadienyl acetate	Structural Classification Natural Products Animals Source classification	Others
(E,E)-9,11-Tetradecadienyl acetate is a female sex pheromone isolated from light-induced isomerization products in female coastal noctuid moths .

HY-N7523

Neoxanthin	Structural Classification Natural Products Classification of Application Fields Source classification Plants Food Research Agricultural Research other families Microorganisms Pigments Abscisic acid Phytohormone Disease Research Fields Cancer	DNA/RNA Synthesis Apoptosis
Neoxanthin is a major xanthophyll carotenoid and a precursor of the plant hormone abscisic acid in dark green leafy vegetables. Neoxanthin is a potent antioxidant and light-harvesting pigment. Neoxanthin induces apoptosis and has anticancer actions .

HY-N9625

Violaxanthin	Structural Classification Natural Products Microorganisms Viola tricolor L. Source classification Violaceae Plants	Photosystem II
Violaxanthin is a carotenoid which can be biosynthesized from zeaxanthin with zeaxanthin epoxidase (ZEP) by way of antheraxanthin only in photosynthetic eukaryotes including higher plants and involved in the xanthophyll cycle to eliminate excessive light energy .

HY-N7270

Apigenin-7-diglucuronide	Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology	Others
Apigenin-7-diglucuronide is a flavonoid glycoside and is present in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation .

HY-N7523R

Neoxanthin (Standard)	Structural Classification Natural Products Microorganisms other families Source classification Plants	DNA/RNA Synthesis Apoptosis
Neoxanthin (Standard) is the analytical standard of Neoxanthin. This product is intended for research and analytical applications. Neoxanthin is a major xanthophyll carotenoid and a precursor of the plant hormone abscisic acid in dark green leafy vegetables. Neoxanthin is a potent antioxidant and light-harvesting pigment. Neoxanthin induces apoptosis and has anticancer actions .

HY-N9625R

Violaxanthin (Standard)	Structural Classification Natural Products Microorganisms Viola tricolor L. Source classification Violaceae Plants	Photosystem II
Violaxanthin (Standard) is the analytical standard of Violaxanthin. This product is intended for research and analytical applications. Violaxanthin is a carotenoid which can be biosynthesized from zeaxanthin with zeaxanthin epoxidase (ZEP) by way of antheraxanthin only in photosynthetic eukaryotes including higher plants and involved in the xanthophyll cycle to eliminate excessive light energy .

HY-N10611

Elsinochrome A	Structural Classification Natural Products Microorganisms Source classification	Reactive Oxygen Species Apoptosis Autophagy Fungal Fluorescent Dye
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .

HY-12591A

D-Luciferin Maximum Cited Publications 43 Publications Verification D-(-)-Luciferin; Firefly luciferin; Beetle Luciferin	Natural Products Animals Source classification Other Diseases Disease Research Fields	Fluorescent Dye
D-luciferin is the natural substrate of the enzyme luciferase (Luc) that catalyzes the production of the typical yellowgreen light of fireflies. The 560 nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase concentration when the substrate luciferin is present in excess. The luciferase (luc) gene is a popular reporter gene for research and agent screening. Chemiluminescent techniques are virtually background-free, making the luc reporter gene ideal for detecting low-level gene expression. As little as 0.02 pg of luciferase can be reliably measured in a standard scintillation counter. In addition to its role as a reporter of gene expression, luciferase is commonly used in an extremely sensitive assay for ATP . We of er the firefly luciferase (HY-P1004), luciferin free acid (HY-12591A), as well as its water-soluble sodium salts (HY-12591) and potassium salts (HY-12591B) .

HY-N7171

4,4'-Di-O-methylellagic acid 4,4'-DiOMEA; Nasutin C	Structural Classification Animals Source classification Phenols Polyphenols	Wnt
4,4'-Di-O-methylellagic acid (4,4'-DiOMEA; Nasutin C) can be isolated from the Australian termites. 4,4'-Di-O-methylellagic acid is blue-fluorescent under ultra-violet light . 4,4'-Di-O-methylellagic acid inhibits colon cancer cell proliferation via the wnt signal pathway .

HY-P9954

Catumaxomab	Classification of Application Fields Disease Research Fields Cancer	CD3
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers .

HY-N11499

Myricetin 3-O-α-L-arabinopyranoside	Structural Classification Flavonoids Flavones Source classification Plants Sapotaceae Pouteria torta (Mart.) Radlk.	Bacterial
Myricetin 3-O-α-L-arabinopyranoside is a quercetin derivative and plant flavonoid with antioxidant, antibacterial and antiurease effects. Myricetin 3-O-α-L-arabinopyranoside inhibits A2E photooxidation-induced RPE cell death. Myricetin 3-O-α-L-arabinopyranoside is protective against retinal degeneration and protects against blue light (BL)-induced damage in RPE cells and mouse models .

HY-B1247

Protoporphyrin IX 10+ Cited Publications	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma .

HY-N6871

Abietic acid	Infection Structural Classification Colophony Classification of Application Fields Pinaceae Ketones, Aldehydes, Acids Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	Bacterial IKK Ferroptosis
Abietic acid, an orally active diterpene isolated from Colophony, displays significant anti-proliferative, anti-inflammatory, anti-obesity effect, bacteriostatic, cell cycle arresting and pro-apoptotic activities. Abietic acid inhibits lipoxygenase activity for allergy. Abietic acid enhances cell migration and tube formation in HUVECs. Abietic acid induces significant angiogenic potential, which is associated with upregulation of extracellular signal-regulated kinase (ERK) and p38 expression. Abietic acid attenuates sepsis-induced lung injury by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway to inhibit M1 macrophage polarization. Abietic acid exhibits a positive effect against liver injury by attenuating inflammation and ferroptosis. Abietic acid shows accelerated wound closure in a mouse model of cutaneous wounds. Abietic acid significantly reduces the proliferation and growth of NSCLC cells by IKKβ inhibition.Additionally, Abietic acid ameliorates psoriasis-like inflammation and modulates gut microbiota in mice. Abietic acid is promising for research in non-small-cell lung cancer (NSCLC), liver injury-related deseases and psoriasis .

HY-N0194

Asiatic acid 3 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Tagetes lucida Cav. Umbelliferae Plants Inflammation/Immunology Disease Research Fields	Apoptosis Parasite
Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

HY-N0194R

Asiatic acid (Standard)	Triterpenes Structural Classification Terpenoids Source classification Tagetes lucida Cav. Umbelliferae Plants	Apoptosis Parasite
Asiatic acid (Standard) is the analytical standard of Asiatic acid. This product is intended for research and analytical applications. Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

Cat. No.	Product Name	Chemical Structure

HY-131123S1

N-Nitrosomorpholine-d8
N-Nitrosomorpholine-d₈ is deuterium labeled N-Nitrosomorpholine. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[1].

HY-B0265S

Nimodipine-d7
Nimodipine-d₇ is the deuterium labeled Nimodipine. Nimodipine (BAY-e 9736) is an orally active, well-tolerated and light-sensitive dihydropyridine calcium antagonist. Nimodipine can be used for the research of cerebrovascular disorders[1].

HY-134928AS

Pyridinium bisretinoid A2E-d4 TFA
Pyridinium bisretinoid A2E-d₄ TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species .

HY-131123S

N-Nitrosomorpholine-d4
N-Nitrosomorpholine-d₄ is the deuterium labeled N-Nitrosomorpholine[1]. N-Nitrosomorpholine is a nitrosamine that is sensitive to light. N-nitrosomorpholine is a strong animal carcinogen[2].

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Species:	Human (18) Mouse (4) Rat (1) Pig (2)
Tag:	His (22) SUMO (1) Tag Free (1) Myc (2) GST (1) Fc (2) Flag (1)
Source:	HEK293 (6) Sf9 insect cells (4) P. pastoris (1) E. coli (14)


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