2. Gene
  3. Hdac1 - histone deacetylase 1 Gene

Hdac1 - histone deacetylase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 297893 | Gene type: protein coding

About Hdac1

Primary_assembly 5: 141,853,989-141,881,111 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 189 orthologues, 12 paralogues and is associated with 30 phenotypes. Biased expression in Thymus (RPKM 374.), Adrenal (RPKM 298.9) and 9 other tissues.

Summary

Enables DNA-binding transcription factor binding activity; chromatin binding activity; and histone deacetylase activity. Involved in several processes, including positive regulation of cytokine production; regulation of apoptotic process; and regulation of protein modification process. Located in several cellular components, including chromatin; neuron projection; and perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of pulmonary hypertension. Orthologous to human HDAC1 (histone deacetylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hdac1 Products(1)

mRNA Protein Name
NM_001025409.1 NP_001020580.1 histone deacetylase 1

Hdac1 Protein Structure

HDAC1

HDAC1: cd10010 (3 - 373)

  • 0
  • 100
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  • 400
  • 482 a.a.
Protein Preferred Names Protein Names

histone deacetylase 1

HD1

protein deacetylase HDAC1

protein decrotonylase HDAC1

Related Agents

Approval
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.95% Yes
HY-10585 Valproic acid Inhibitor 98.88% Unkown
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-109015 Tucidinostat Inhibitor 98.60% Unkown
HY-10585A Valproic acid sodium Inhibitor 98.14% Unkown
HY-12164 Mocetinostat Inhibitor 99.68% Yes
HY-13322 Pracinostat Inhibitor 99.82% Yes
HY-14842 Givinostat Inhibitor 98.16% Yes
HY-10585B Valproic acid (sodium)(2:1) Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Phase
HY-12163 Entinostat Inhibitor 99.82% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-10990 Abexinostat Inhibitor 98.63% Phase 3
HY-13606 Dacinostat Inhibitor 98.45% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.34% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 98.81% Phase 2
HY-100748 Zabadinostat Inhibitor 99.81% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 2
HY-101780 Tinostamustine Inhibitor 99.42% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-14718 Resminostat Inhibitor 99.84% Phase 2
HY-13216 Pyroxamide Inhibitor 99.54% Phase 1
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
HY-124295 MPT0E028 Inhibitor 99.63% Phase 1
HY-10226 JNJ-16241199 Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (177)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13271A Tubastatin A Inhibitor 98.37% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-13428 Tubacin Inhibitor 99.54% Unkown
HY-15224 PCI-34051 Inhibitor 99.84% Unkown
HY-13271 Tubastatin A Hydrochloride Inhibitor 98.19% Unkown
HY-18613 CAY10603 Inhibitor ≥98.0% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-16699 Nexturastat A Inhibitor 98.28% Unkown
HY-16425 RG2833 Inhibitor 99.86% Unkown
HY-19618 BRD3308 Inhibitor 98.82% Unkown
HY-100719 BRD-6929 Inhibitor 99.04% Unkown
HY-104008 ACY-957 Inhibitor 99.66% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-153358 TNG260 Inhibitor 99.91% Unkown
HY-111400 SR-4370 Inhibitor 99.95% Unkown
HY-144315 CYD19 Inhibitor 95.48% Unkown
HY-18976 UF010 99.84% Unkown
HY-19328 ACY-775 Inhibitor 99.69% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% Unkown
HY-100871 WT-161 Inhibitor 98.36% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-W009776 Suberoyl bis-hydroxamic acid Inhibitor ≥98.0% Unkown
HY-18712 BG45 Inhibitor 99.96% Unkown
HY-19747 HPOB Inhibitor 99.80% Unkown
HY-116818 Crebinostat Inhibitor 99.79% Unkown
HY-114414 HDACs/mTOR Inhibitor 1 Inhibitor 99.01% Unkown
HY-N11692 9-Hydroxyoctadecanoic acid Inhibitor ≥98.0% Unkown
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.72% Unkown
HY-114303 CM-675 Inhibitor 99.53% Unkown
HY-10585R Valproic acid (Standard) Inhibitor / Unkown
HY-12954 PTACH Inhibitor 99.65% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-100384 NKL 22 Inhibitor 97.27% Unkown
HY-146346 HD-TAC7 Inhibitor 98.75% Unkown
HY-110280 MC1742 Inhibitor 99.20% Unkown
HY-124053 BRD2492 Inhibitor 99.18% Unkown
HY-117583 cis-BG47 Inhibitor 98.02% Unkown
HY-18700 BRD73954 Inhibitor ≥98.0% Unkown
HY-102083 BRD4884 Inhibitor ≥99.0% Unkown
HY-152134 HDAC6 degrader-3 Degrader 98.60% Unkown
HY-141427 MOCPAC 99.64% Unkown
HY-158075 DNMT/HDAC-IN-1 Inhibitor / Unkown
HY-124782 HDAC8-IN-8 Inhibitor 99.01% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-152174 HDAC-IN-52 Inhibitor 99.46% Unkown
HY-156422 KPZ560 Inhibitor 99.72% Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-162616 SelSA Inhibitor 99.83% Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-112147 IDO1 and HDAC1 Inhibitor Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-150109 Purinostat mesylate Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-168088 DNMT1/HDAC-IN-1 Inhibitor / Unkown
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / Unkown
HY-162910 HDAC-IN-79 Inhibitor / Unkown
HY-152133 PROTAC HDAC6 degrader 1 Degrader / Unkown
HY-144332 PHD2/HDACs-IN-1 Inhibitor / Unkown
HY-158371 HDAC/CK2-IN-1 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-12487 NL-103 Inhibitor / Unkown
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / Unkown
HY-147991 PDE5/HDAC-IN-1 Inhibitor / Unkown
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% Unkown
HY-145845 HDAC1/MAO-B-IN-1 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-125645 M122 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-162781 HDAC1/6-IN-2 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-143462 c-Met/HDAC-IN-2 Inhibitor / Unkown
HY-156444 HDAC1/CDK7-IN-1 Inhibitor / Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-144725 HDAC1/6-IN-1 Inhibitor / Unkown
HY-147892 HDAC-IN-42 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-150597 HDAC-IN-46 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-169439 Temozolomide-amino hydrochloride / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-117374 HDAC3-IN-1 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-109015S Tucidinostat-d4 Inhibitor / Unkown
HY-126566 Trichostatin C Inhibitor / Unkown
HY-151153 HDAC1-IN-5 Inhibitor / Unkown
HY-163368 HDAC6-IN-34 Inhibitor / Unkown
HY-130493 HPB Inhibitor / Unkown
HY-163503 HDAC6-IN-38 Inhibitor / Unkown
HY-150503 KH-259 Inhibitor / Unkown
HY-147840 HDAC-IN-41 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-144098 HDAC8-IN-2 Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-169433 Naph-Se-TMZ Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-161688 HDAC-IN-73 Inhibitor / Unkown
HY-163090 HR488B Inhibitor / Unkown
HY-163535 J208 Inhibitor / Unkown
HY-162361 HDAC1-IN-7 Inhibitor / Unkown
HY-162769 HDAC3-IN-5 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-150004 c-Met/HDAC-IN-3 Inhibitor / Unkown
HY-154855 HDAC-IN-56 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-168502 HDAC-IN-81 Inhibitor / Unkown
HY-146539 HDAC-IN-35 Inhibitor / Unkown
HY-162487 HDAC-IN-72 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-162330 HDAC6-IN-36 Inhibitor / Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-157385 HDAC-IN-67 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-169156 HDAC6-IN-49 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-157481 HDAC1-IN-6 Inhibitor / Unkown
HY-169400 HDACs/EZH2-IN-1 Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-161155 HDAC6-IN-31 Inhibitor / Unkown
HY-161984 HDAC-IN-76 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-169938 LSD1/HDAC-IN-2 Inhibitor / Unkown
HY-151248 HDAC2-IN-1 Inhibitor / Unkown
HY-161464 Chlopynostat Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-163894 HDAC6-IN-48 Inhibitor / Unkown
HY-161783 HDAC6-IN-45 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-143241 HDAC-IN-34 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-169405 AAK1/HDACs-IN-1 Inhibitor / Unkown
HY-162678 HDAC-IN-75 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-161868 DLC-50 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-119316A CM-545 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-117583A BG47 Inhibitor / Unkown
HY-124337 BG48 Inhibitor / Unkown
HY-135714 Bavarostat Inhibitor / Unkown
HY-148624 CHDI-00484077 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac1 NCBI NCBI:3065