2. Gene
  3. Hdac1 - histone deacetylase 1 Gene

Hdac1 - histone deacetylase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HD1; RPD3; MommeD5; Hdac1-ps

Gene ID: 433759 | Gene type: protein coding

About Hdac1

Chromosome 4: 129,409,897-129,436,506 reverse strand.GRCm39:CM000997.3

This gene has 7 transcripts (splice variants), 277 orthologues, 10 paralogues and is associated with 31 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 54.8), placenta adult (RPKM 51.1) and 28 other tissues.

Summary

Enables several functions, including E-box binding activity; Krueppel-associated box domain binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including animal organ development; histone deacetylation; and regulation of gene expression. Acts upstream of or within several processes, including negative regulation of signal transduction; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in heterochromatin; neuronal cell body; and nucleus. Part of NuRD complex and transcription repressor complex. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human HDAC1 (histone deacetylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hdac1 Products(1)

mRNA Protein Name
NM_008228.3 NP_032254.1 histone deacetylase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
14593184 MGI
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
18486321 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
24736997 MGI
enables Krueppel-associated box domain binding IPI
IPI: Inferred from physical interaction
21177534 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
19235719 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15608638 MGI
enables histone deacetylase activity IDA
IDA: Inferred from direct assay
10615135 MGI
enables histone decrotonylase activity IDA
IDA: Inferred from direct assay
30279482 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
22770845 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8917507 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
24413057 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
8917507 MGI
Biological Process GO Annotation Evidence Reference Source
involved in circadian regulation of gene expression IDA
IDA: Inferred from direct assay
15226430 MGI
involved in circadian rhythm IDA
IDA: Inferred from direct assay
24736997 MGI
involved in embryonic digit morphogenesis IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within endoderm development IDA
IDA: Inferred from direct assay
15060137 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
15060137 MGI
involved in epidermal cell differentiation IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in eyelid development in camera-type eye IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in fungiform papilla formation IGI
IGI: Inferred from genetic interaction
21093383 MGI
involved in hair follicle placode formation IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within hippocampus development IGI
IGI: Inferred from genetic interaction
19380719 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9271381 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21960634 MGI
involved in negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
19805123 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
19503085 MGI
acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8917507 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within neuron differentiation IGI
IGI: Inferred from genetic interaction
19380719 MGI
involved in odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
19503085 MGI
involved in positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
21093383 MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation IGI
IGI: Inferred from genetic interaction
19503085 MGI
Cellular Component GO Annotation Evidence Reference Source
part of NuRD complex IDA
IDA: Inferred from direct assay
11836251 MGI
part of NuRD complex IPI
IPI: Inferred from physical interaction
14645126 MGI
located in chromatin IDA
IDA: Inferred from direct assay
21093383 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
14519686 MGI
part of histone deacetylase complex IPI
IPI: Inferred from physical interaction
14645126 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
18651664 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11115394 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
19796622 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
17707228 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
17182846 MGI
part of transcription repressor complex IPI
IPI: Inferred from physical interaction
17182846 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hdac1 Protein Structure

HDAC1

HDAC1: cd10010 (3 - 373)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
Protein Preferred Names Protein Names

histone deacetylase 1

protein deacetylase HDAC1

protein decrotonylase HDAC1

Related Agents

Approval
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10221 Vorinostat Inhibitor 99.95% Yes
HY-10585 Valproic acid Inhibitor 99.19% Unkown
HY-15149 Romidepsin Inhibitor 99.98% Unkown
HY-109015 Tucidinostat Inhibitor 98.60% Unkown
HY-10585A Valproic acid sodium Inhibitor ≥99.0% Unkown
HY-12164 Mocetinostat Inhibitor 99.68% Yes
HY-14842 Givinostat Inhibitor 98.16% Yes
HY-13322 Pracinostat Inhibitor 99.82% Yes
HY-10585B Valproic acid (sodium)(2:1) Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Phase
HY-14718A Resminostat hydrochloride Inhibitor 99.68% Phase 4
HY-12163 Entinostat Inhibitor 99.82% Phase 3
HY-50934 Tacedinaline Inhibitor 99.32% Phase 3
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-13606 Dacinostat Inhibitor 98.45% Phase 3
HY-14842B Givinostat hydrochloride monohydrate Inhibitor ≥98.0% Phase 3
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Phase 3
HY-16026 Ricolinostat Inhibitor 99.83% Phase 2
HY-15433 Quisinostat Inhibitor 98.02% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-100748 Zabadinostat Inhibitor 99.81% Phase 2
HY-16012A Domatinostat Inhibitor 99.43% Phase 2
HY-101780 Tinostamustine Inhibitor 99.64% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-14718 Resminostat Inhibitor 99.84% Phase 2
HY-13216 Pyroxamide Inhibitor 99.54% Phase 1
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1
HY-15994 Citarinostat Inhibitor 99.30% Phase 1
HY-10226 JNJ-16241199 Inhibitor 99.05% Phase 1
Pre-clinical Phase
Bioactive Molecules (190)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13271A Tubastatin A Inhibitor 98.37% Unkown
HY-18998 LMK-235 Inhibitor 99.61% Unkown
HY-13428 Tubacin Inhibitor 99.54% Unkown
HY-15224 PCI-34051 Inhibitor 99.84% Unkown
HY-13271 Tubastatin A Hydrochloride Inhibitor 98.19% Unkown
HY-18613 CAY10603 Inhibitor ≥98.0% Unkown
HY-19327 ACY-738 Inhibitor 99.92% Unkown
HY-16699 Nexturastat A Inhibitor 98.28% Unkown
HY-16425 RG2833 Inhibitor 99.86% Unkown
HY-19618 BRD3308 Inhibitor 98.82% Unkown
HY-100719 BRD-6929 Inhibitor ≥99.0% Unkown
HY-144315 CYD19 Inhibitor 99.76% Unkown
HY-119939 CHDI-390576 Inhibitor 98.07% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-19328 ACY-775 Inhibitor 99.69% Unkown
HY-153358 TNG260 Inhibitor 99.91% Unkown
HY-104008 ACY-957 Inhibitor 99.66% Unkown
HY-111400 SR-4370 Inhibitor 99.95% Unkown
HY-123295 HDAC3-IN-T247 Inhibitor 98.94% Unkown
HY-100871 WT-161 Inhibitor 98.36% Unkown
HY-18976 UF010 99.84% Unkown
HY-116818 Crebinostat Inhibitor 99.79% Unkown
HY-19348 Pimelic Diphenylamide 106 Inhibitor 98.54% Unkown
HY-W009776 Suberoyl bis-hydroxamic acid Inhibitor ≥98.0% Unkown
HY-18712 BG45 Inhibitor 99.96% Unkown
HY-19747 HPOB Inhibitor 99.80% Unkown
HY-N11692 9-Hydroxyoctadecanoic acid Inhibitor ≥98.0% Unkown
HY-114414 HDACs/mTOR Inhibitor 1 Inhibitor 99.01% Unkown
HY-126330 SS-208 Inhibitor 99.00% Unkown
HY-114303 CM-675 Inhibitor 99.53% Unkown
HY-124295 Imofinostat Inhibitor 99.40% Unkown
HY-130538 1-Naphthohydroxamic acid Inhibitor 99.72% Unkown
HY-10585R Valproic acid (Standard) Inhibitor / Unkown
HY-12954 PTACH Inhibitor 99.65% Unkown
HY-110280 MC1742 Inhibitor 99.20% Unkown
HY-100384 NKL 22 Inhibitor 97.26% Unkown
HY-117583 cis-BG47 Inhibitor 98.02% Unkown
HY-152134 HDAC6 degrader-3 Degrader 98.60% Unkown
HY-124053 BRD2492 Inhibitor 99.18% Unkown
HY-146346 HD-TAC7 Inhibitor 98.75% Unkown
HY-18700 BRD73954 Inhibitor ≥98.0% Unkown
HY-102083 BRD4884 Inhibitor ≥99.0% Unkown
HY-156422 KPZ560 Inhibitor 99.72% Unkown
HY-141427 MOCPAC 99.64% Unkown
HY-158075 DNMT/HDAC-IN-1 Inhibitor 99.87% Unkown
HY-124782 HDAC8-IN-8 Inhibitor 99.01% Unkown
HY-131708A FNDR-20123 Inhibitor 98.08% Unkown
HY-117554 BRD9757 Inhibitor 99.75% Unkown
HY-162616 SelSA Inhibitor 99.83% Unkown
HY-151261 HDAC6-IN-13 Inhibitor 98.08% Unkown
HY-152174 HDAC-IN-52 Inhibitor 99.46% Unkown
HY-130493 HPB Inhibitor / Unkown
HY-151464 SHP2/HDAC-IN-1 Inhibitor / Unkown
HY-131708 FNDR-20123 free base Inhibitor / Unkown
HY-112147 IDO1 and HDAC1 Inhibitor Inhibitor / Unkown
HY-128582 PI3K/HDAC-IN-1 Inhibitor / Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-146679 HDAC6-IN-6 Inhibitor / Unkown
HY-143497 HDAC1/2 and CDK2-IN-1 Inhibitor / Unkown
HY-150109 Purinostat mesylate Inhibitor 99.45% Unkown
HY-168088 DNMT1/HDAC-IN-1 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-162678 HDAC-IN-75 Inhibitor / Unkown
HY-146539 HDAC-IN-35 Inhibitor / Unkown
HY-146293 HDAC6/HSP90-IN-1 Inhibitor / Unkown
HY-115941 HDAC-IN-9 Inhibitor / Unkown
HY-162910 HDAC-IN-79 Inhibitor / Unkown
HY-151153 HDAC1-IN-5 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-161464 Chlopynostat Inhibitor / Unkown
HY-151443 HDAC-IN-47 Inhibitor / Unkown
HY-161350 ALK/HDAC-IN-1 Inhibitor / Unkown
HY-151364 HDAC6/8/BRPF1-IN-1 Inhibitor / Unkown
HY-162781 HDAC1/6-IN-2 Inhibitor / Unkown
HY-163368 HDAC6-IN-34 Inhibitor / Unkown
HY-149029 TH-6 Inhibitor 95.00% Unkown
HY-144297 HDAC1-IN-3 Inhibitor / Unkown
HY-143233 PIM-1/HDAC-IN-1 Inhibitor / Unkown
HY-168962 HDAC-IN-88 Inhibitor / Unkown
HY-150503 KH-259 Inhibitor / Unkown
HY-161155 HDAC6-IN-31 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-173064 DS-103 Inhibitor / Unkown
HY-146276 CDK/HDAC-IN-2 Inhibitor / Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-162319 Tubulin/HDAC-IN-4 Inhibitor / Unkown
HY-146392 HDAC-IN-39 Inhibitor / Unkown
HY-163282 NB512 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-163207 sEH/HDAC6-IN-1 Inhibitor / Unkown
HY-157481 HDAC1-IN-6 Inhibitor / Unkown
HY-146159 PI3K/HDAC-IN-2 Inhibitor / Unkown
HY-149946 HDAC-IN-57 Inhibitor / Unkown
HY-170379 HDAC-IN-84 Inhibitor / Unkown
HY-169938 LSD1/HDAC-IN-2 Inhibitor / Unkown
HY-150004 c-Met/HDAC-IN-3 Inhibitor / Unkown
HY-169156 HDAC6-IN-49 Inhibitor / Unkown
HY-161783 HDAC6-IN-45 Inhibitor / Unkown
HY-143324 A2AAR/HDAC-IN-1 Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-162361 HDAC1-IN-7 Inhibitor / Unkown
HY-161524 HDAC6-IN-43 Inhibitor / Unkown
HY-169405 AAK1/HDACs-IN-1 Inhibitor / Unkown
HY-152133 PROTAC HDAC6 degrader 1 Degrader / Unkown
HY-144098 HDAC8-IN-2 Inhibitor / Unkown
HY-151569 SAHA-OH Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-172359 PROTAC HDAC6 degrader 4 Degrader / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-151248 HDAC2-IN-1 Inhibitor / Unkown
HY-169433 Naph-Se-TMZ Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-12487 NL-103 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-146351 HDAC-IN-38 Inhibitor / Unkown
HY-145852 Top/HDAC-IN-2 Inhibitor / Unkown
HY-168650 ROCK/HDAC-IN-1 Inhibitor / Unkown
HY-163535 J208 Inhibitor / Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.14% Unkown
HY-145845 HDAC1/MAO-B-IN-1 Inhibitor / Unkown
HY-162769 HDAC3-IN-5 Inhibitor / Unkown
HY-151896 HDAC6-IN-14 Inhibitor / Unkown
HY-147991 PDE5/HDAC-IN-1 Inhibitor / Unkown
HY-157740 XSJ-10 Inhibitor / Unkown
HY-161688 HDAC-IN-73 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-133147 HDAC3/6-IN-2 Inhibitor / Unkown
HY-150577 HDAC-IN-45 Inhibitor / Unkown
HY-163090 HR488B Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 Inhibitor / Unkown
HY-147892 HDAC-IN-42 Inhibitor / Unkown
HY-154855 HDAC-IN-56 Inhibitor / Unkown
HY-150597 HDAC-IN-46 Inhibitor / Unkown
HY-151897 HDAC-IN-49 Inhibitor / Unkown
HY-149208 HDAC-IN-53 Inhibitor / Unkown
HY-161984 HDAC-IN-76 Inhibitor / Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-150774 HDAC6/HSP90-IN-2 Inhibitor / Unkown
HY-152146 HDAC-IN-50 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-143877 NN-390 Inhibitor / Unkown
HY-162487 HDAC-IN-72 Inhibitor / Unkown
HY-143241 HDAC-IN-34 Inhibitor / Unkown
HY-156444 HDAC1/CDK7-IN-1 Inhibitor / Unkown
HY-141701 mTOR/HDAC-IN-1 Inhibitor / Unkown
HY-170495 HDAC6 degrader-5 Inhibitor / Unkown
HY-109015S Tucidinostat-d4 Inhibitor / Unkown
HY-147873 NMDAR/HDAC-IN-1 Inhibitor / Unkown
HY-158371 HDAC/CK2-IN-1 Inhibitor / Unkown
HY-144293 HDAC-IN-31 Inhibitor / Unkown
HY-163503 HDAC6-IN-38 Inhibitor / Unkown
HY-169439 Temozolomide-amino hydrochloride / Unkown
HY-169400 HDACs/EZH2-IN-1 Inhibitor / Unkown
HY-147840 HDAC-IN-41 Inhibitor / Unkown
HY-149578 Tubulin/HDAC-IN-3 Inhibitor / Unkown
HY-152226 MC2590 Inhibitor / Unkown
HY-144395 HDAC6-IN-4 Inhibitor / Unkown
HY-125645 M122 Inhibitor / Unkown
HY-117374 HDAC3-IN-1 Inhibitor / Unkown
HY-147934 HDAC8-IN-3 Inhibitor / Unkown
HY-172159 FF2039 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-126566 Trichostatin C Inhibitor / Unkown
HY-144725 HDAC1/6-IN-1 Inhibitor / Unkown
HY-159172 HDAC3-IN-4 Inhibitor / Unkown
HY-144292 HDAC-IN-30 Inhibitor / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-157385 HDAC-IN-67 Inhibitor / Unkown
HY-168477 HDAC1-IN-8 Inhibitor / Unkown
HY-172200 PD-L1/HDAC6-IN-1 Inhibitor / Unkown
HY-146750 HDAC-IN-37 Inhibitor / Unkown
HY-162955 LSD1/HDAC-IN-1 Inhibitor / Unkown
HY-161868 DLC-50 Inhibitor / Unkown
HY-143462 c-Met/HDAC-IN-2 Inhibitor / Unkown
HY-168502 HDAC-IN-81 Inhibitor / Unkown
HY-144332 PHD2/HDACs-IN-1 Inhibitor / Unkown
HY-172133 HDAC3-IN-6 Inhibitor / Unkown
HY-163894 HDAC6-IN-48 Inhibitor / Unkown
HY-162330 HDAC6-IN-36 Inhibitor / Unkown
HY-170966 HDAC1-IN-9 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-159171 sEH/HDAC6-IN-2 Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown
HY-148624 CHDI-00484077 Inhibitor / Unkown
HY-150109A Purinostat Inhibitor / Unkown
HY-135714 Bavarostat Inhibitor / Unkown
HY-124337 BG48 Inhibitor / Unkown
HY-155222 TW9 Inhibitor / Unkown
HY-117583A BG47 Inhibitor / Unkown
HY-119316A CM-545 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hdac1 NCBI NCBI:3065