1. Gene
  2. PRKAB2 - protein kinase AMP-activated non-catalytic subunit beta 2 Gene

PRKAB2 - protein kinase AMP-activated non-catalytic subunit beta 2 Gene

Homo sapiens
Gene ID: 5565 | Gene type: protein coding

About PRKAB2

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:147,155,106-147,172,470 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 16.7), liver (RPKM 11.0) and 25 other tissues.

Summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing Enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key Enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

PRKAB2 Products(1)

mRNA Protein Name
NM_005399.5 NP_005390.1 5'-AMP-activated protein kinase subunit beta-2

PRKAB2 Protein Structure

AMPKBI

AMPKBI: 5'-AMP-activated protein kinase beta subunit, interaction domain (198 - 272)

  • 0
  • 100
  • 200
  • 272 a.a.
Protein Preferred Names Protein Names

5'-AMP-activated protein kinase subunit beta-2

5'-AMP-activated protein kinase, beta-2 subunit

Recombinant PRKAB2 Proteins

Cat. No. Product Name Accession Purity
HY-P76143 AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) P54619 (M1-P331)&O43741 (M1-I272)&Q13131 (M1-Q559) ≥95%
HY-P76144 AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) P54619 (M1-P331)&O43741 (M1-I272)&P54646 (M1-R552) ≥95%

Related Diseases

Diseases Alias
Acute Apical Periodontitis

Acute Apical Periodontitis Of Pulpal Origin

Acute Apical Periodontitis Nos

Aap - [Acute Apical Periodontitis]

Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic

Tetralogy Of Fallot

TOF

Fallot Tetralogy

Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle

Tetrad Of Fallot

Fallot Tetrad

Fallot Disease

Fallot Complex

Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy

Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle

Interventricular Septal Defect, In Tetralogy Of Fallot

Ventricular Septal Defect With Obstructed Right Ventricular Outflow

Tof - [Tetralogy Of Fallot]

Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]

Pulmonary Atresia, Ventricular Septal Defect And Mapcas

Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris PRKAB2 VGNC VGNC:44970
Macaca mulatta PRKAB2 VGNC VGNC:76402
Mus musculus PRKAB2 MGD MGI:1336185
Rattus norvegicus PRKAB2 RGD RGD:620905
Bos taurus PRKAB2 VGNC VGNC:33320