PRKAB2 - protein kinase AMP-activated non-catalytic subunit beta 2 Gene

Homo sapiens

Gene ID: 5565 | Gene type: protein coding

About PRKAB2

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:147,155,106-147,172,470 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 16.7), liver (RPKM 11.0) and 25 other tissues.

Summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing Enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key Enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

PRKAB2 Products(1)

mRNA	Protein	Name
NM_005399.5	NP_005390.1	5'-AMP-activated protein kinase subunit beta-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to AMP-activated protein kinase activity	IDA IDA: Inferred from direct assay	21399626	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16306228	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to nutrient levels	IDA IDA: Inferred from direct assay	25412657	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nucleotide-activated protein kinase complex	IDA IDA: Inferred from direct assay	17851531	GOA
part of nucleotide-activated protein kinase complex	IPI IPI: Inferred from physical interaction	25412657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKAB2 Protein Structure

AMPKBI

0
100
200
272 a.a.

Protein Preferred Names

Protein Names

5'-AMP-activated protein kinase subunit beta-2

5'-AMP-activated protein kinase, beta-2 subunit

Recombinant PRKAB2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76143	AMPK gamma 1/beta 2/alpha 1 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&O43741 (M1-I272)&Q13131 (M1-Q559)	≥95%
HY-P76144	AMPK gamma 1/beta 2/alpha 2 Heterotrimer Protein, Human (sf9, His-GST)	P54619 (M1-P331)&O43741 (M1-I272)&P54646 (M1-R552)	≥95%

Related Diseases

Diseases

Alias

Acute Apical Periodontitis

Acute Apical Periodontitis Of Pulpal Origin	Acute Apical Periodontitis Nos
Aap - [Acute Apical Periodontitis]

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11103	PRKAB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PRKAB2	VGNC	VGNC:44970
Macaca mulatta	PRKAB2	VGNC	VGNC:76402
Mus musculus	PRKAB2	MGD	MGI:1336185
Rattus norvegicus	PRKAB2	RGD	RGD:620905
Bos taurus	PRKAB2	VGNC	VGNC:33320

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