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Isoforms Recommended:	MDM2 MDM2 MDM2

Results for "

MDM2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (33) Autophagy (7) Bcl-2 Family (1) c-Myc (1) Casein Kinase (3) CDK (3) Deubiquitinase (5) Dihydroorotate Dehydrogenase (3) E1/E2/E3 Enzyme (39) E3 Ligase Ligand-Linker Conjugates (3) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (3) Ferroptosis (1) Fungal (1) HDAC (3) Histone Methyltransferase (3) IAP (2) Isotope-Labeled Compounds (3) Ligands for E3 Ligase (6) MDM-2/p53 (104) Molecular Glues (1) NF-κB (2) PARP (2) PROTACs (16) Sirtuin (3) Small Interfering RNA (siRNA) (3) Target Protein Ligand-Linker Conjugates (9) β-catenin (2)
By Research Areas:	Cancer (153) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (2) Neurological Disease (1)
Click Chemistry:	Azide (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

159

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128837

Nutlin carboxylic acid MDM2 ligand 1; E3 ligase Ligand 16	Ligands for E3 Ligase	Cancer
Nutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based *MDM2* ligand. Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC .

HY-P5930

HOXB7 8–25 MDM2 32-46	Ligands for E3 Ligase	Cancer
HOXB7 8–25 (MDM2 32-46) is an *MDM2*-derived peptide epitope and can elicit antigen-specifc and tumor-reactive CD4 ⁺ T cell responses .

HY-RS08264

MDM2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MDM2 Human Pre-designed siRNA Set A contains three designed siRNAs for MDM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MDM2 Human Pre-designed siRNA Set A MDM2 Human Pre-designed siRNA Set A

HY-RS08265

Mdm2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mdm2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mdm2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mdm2 Mouse Pre-designed siRNA Set A Mdm2 Mouse Pre-designed siRNA Set A

HY-RS08266

Mdm2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mdm2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mdm2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mdm2 Rat Pre-designed siRNA Set A Mdm2 Rat Pre-designed siRNA Set A

HY-162035

MDM2-IN-23	Ligands for E3 Ligase	Cancer
MDM2-IN-23 (compound 5d) is an inhibitor of MDM2. MDM2-IN-23 has an IC₅₀ of 60.09 μM on MCF-7 cells .

HY-128836

(4R,5S)-Nutlin carboxylic acid MDM2 ligand 2; E3 ligase Ligand 15	Ligands for E3 Ligase	Cancer
(4R,5S)-Nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs .

HY-161039

MDM2-p53-IN-18	MDM-2/p53	Cancer
MDM2-p53-IN-18 (Compd A-7b) is a *MDM2-p53* interaction inhibitor .

HY-161041

MDM2-p53-IN-20	MDM-2/p53	Cancer
MDM2-p53-IN-20 (Compd B-11j) is a synthetic *MDM2-p53* interaction inhibitor that play an important role in cancer .

HY-161040

MDM2-p53-IN-19	Others	Cancer
MDM2-p53-IN-19 (Compound A-8d) is a chemical intermediate that can be used to synthesize inhibitors of the *MDM2-p53* interaction with anticancer activity .

HY-151170

MDM2/4-p53-IN-2	MDM-2/p53 Apoptosis	Cancer
MDM2/4-p53-IN-2 (2q) is a potent dual **MDM2/ MDM4 inhibitor and p53 activator with the IC₅₀** values of 70.7 nM for MDM2- p53 and 81.4 nM for MDM4-p53 complexes. MDM2/4-p53-IN-2 regulates the cell cycle, induces cell apoptosis and has anticancer activity .

HY-139458

MDM2-IN-21	MDM-2/p53	Cancer
MDM2-IN-21 is a potent *MDM2* inhibitor. MDM2-IN-21 can be used for the research of cancer .

HY-162432

MDM2-IN-27	MDM-2/p53	Cancer
MDM2-IN-27 targets *MDM2* protein (K_i = 0.4 nM). MDM2-IN-27 activates the anti-tumor activity of p53 and induces apoptosis by blocking the negative regulation of p53 by MDM2 .

HY-162247

MDM2-IN-26	MDM-2/p53	Cancer
MDM2-IN-26 (compound A3) is an *MDM2* inhibitor that can activate the tumor suppressor function of p53 by blocking the interaction between MDM2 and p53 (MDM2 is the main negative regulator of p53). MDM2-IN-26 can be used for cancer research .

HY-130684

MDM2-IN-1	MDM-2/p53	Cancer
MDM2-IN-1 (Compound 30) is a synthetic **MDM2-p53 interaction (MDM2)** inhibitor and contains the trans (D-)configuration .

HY-155571

MDM2/XIAP-IN-3	MDM-2/p53 IAP	Cancer
MDM2/XIAP-IN-3 (compound 3e) is a dual *MDM2/XIAP* inhibitor. MDM2/XIAP-IN-3 reduces *MDM2* and XIAP protein levels and increases p53 expression, thereby inhibiting cancer cell growth and causing cell death .

HY-153200

MDM2/XIAP-IN-2	MDM-2/p53	Cancer
MDM2/XIAP-IN-2 is a dual inhibitor of murine double minute 2 (MDM2) and X-linked inhibitor of apoptosis protein (XIAP). MDM2/XIAP-IN-2 degrades MDM2, and inhibits XIAP mRNA translation to inhibits cancer cells. Particularly, MDM2/XIAP-IN-2 inhibits acute lymphoblastic leukemia cell line EU-1 with an IC₅₀ value of 0.3 μM .

HY-148833

MDM2-p53-IN-16	MDM-2/p53	Cancer
MDM2-p53-IN-16 is a *MDM2-p53* complex inhibitor with an IC₅₀ value of 4.3 nM to dissociate human p53/MDM2 complex. MDM2-p53-IN-16 reactivates p53, and induces Glioblastoma Multiforme (GBM) cell apoptosis and cell-cycle arrest. MDM2-p53-IN-16 can be used for the cancer research .

HY-153199

MDM2/XIAP-IN-1	Others	Cancer
MDM2/XIAP-IN-1 (compound 14) is an orally active inhibitor of dual MDM2/XIAP. MDM2/XIAP-IN-1 has anti-cancer activity with an IC₅₀ value of 0.3 μM, which can be used in cance rescrch .

HY-151172

MDM2-p53-IN-15	MDM-2/p53 Apoptosis	Cancer
MDM2-p53-IN-15 is a *MDM2-p53* inhibitor with an IC₅₀ value of 26.1 nM. MDM2-p53-IN-15 inhibits the proliferation of various cancer cells and induces cell apoptosis. MDM2-p53-IN-15 can be used for the research of cancer .

HY-163275

MDM2-IN-24	MDM-2/p53 Apoptosis	Cancer
MDM2-IN-24 (compound A3f) exhibits *MDM2*-inhibiting and MDMX-activating properties in triple-negative breast cancer (TNBC) cells, with apoptotic and anti-proliferative activities .

HY-151171

MDM2/4-p53-IN-3	MDM-2/p53	Cancer
MDM2/4-p53-IN-3 is a *MDM2/4-p53* protein-protein interactions (PPIs) inhibitor (IC₅₀s: 18.5 nM for MDM2-p53, 14.8 nM for MDM4-p53). MDM2/4-p53-IN-3 can be used in the research of cancers, such as colon cancer .

HY-151169

MDM2/4-p53-IN-1	MDM-2/p53	Cancer
MDM2/4-p53-IN-1 is a potent *MDM2-p53* and *MDM4-p53* inhibitor with IC₅₀ values of 35.9, 57.4 nM, respectively. MDM2/4-p53-IN-1 shows antiproliferative activity .

HY-128832

Nutlin-C1-amido-PEG4-C2-N3 MDM2 Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 48	E3 Ligase Ligand-Linker Conjugates	Cancer
Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology. Nutlin-C1-amido-PEG4-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-128843

*PROTAC MDM2* Degrader-4**	PROTACs MDM-2/p53 E1/E2/E3 Enzyme	Cancer
PROTAC MDM2 Degrader-4 is a *MDM2* degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase .

HY-128842

*PROTAC MDM2* Degrader-3**	PROTACs MDM-2/p53 E1/E2/E3 Enzyme	Cancer
PROTAC MDM2 Degrader-3 is a *MDM2* degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase .

HY-128840

*PROTAC MDM2* Degrader-1**	PROTACs MDM-2/p53 E1/E2/E3 Enzyme	Cancer
PROTAC MDM2 Degrader-1 is a *MDM2* degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase (CN108610333A) .

HY-128841

*PROTAC MDM2* Degrader-2**	PROTACs MDM-2/p53 E1/E2/E3 Enzyme	Cancer
PROTAC MDM2 Degrader-2 is a *MDM2* degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase (CN108610333A) .

HY-70027A

*p53 and MDM2* proteins-interaction-inhibitor dihydrochloride**	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is an inhibitor of the interaction between p53 and MDM2 proteins.

HY-70027

*p53 and MDM2* proteins-interaction-inhibitor (chiral)**	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
p53 and MDM2 proteins-interaction-inhibitor (chiral) (Compound 32) is an inhibitor of the interaction between p53 and MDM2 proteins.

HY-70028

*p53 and MDM2* proteins-interaction-inhibitor (racemic)**	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
p53 and MDM2 proteins-interaction-inhibitor (racemic) (Compound 2j) is an inhibitor of the interaction between p53 and MDM2 proteins.

HY-163357

*CDK2/MDM2-IN-1*	CDK MDM-2/p53	Cancer
CDK2/MDM2-IN-1 (III-13) is a dual inhibitor of CDK2/MDM2 with an IC₅₀ value of 2.60 nM for CDK2. CDK2/MDM2-IN-1 has antitumor activity .

HY-149250

*MDMX/MDM2-IN-2*	MDM-2/p53 Apoptosis	Cancer
MDMX/MDM2-IN-2 is a potent *p53-MDM2/MDMX* dual inhibitors with K_is of 0.23 μM and 2.45 μM for MDM2 and MDMX, respectively. MDMX/MDM2-IN-2 inhibits the binding of p53 and MDM2 proteins. MDMX/MDM2-IN-2 restores the function of p53 and enables cell cycle arrest and apoptosis. MDMX/MDM2-IN-2 inhibits cell migration and invasion. MDMX/MDM2-IN-2 has antitumor activity .

HY-168606A

*p53-MDM2-IN-7 hydrochloride*	MDM-2/p53	Cancer
p53-MDM2-IN-7 (compound 6d) (hydrochloride) is a *p53-MDM2* inhibitor. p53-MDM2-IN-7 can be used in anti-cancer research .

HY-163661

*p53-MDM2-IN-5*	Apoptosis Autophagy MDM-2/p53	Cancer
p53-MDM2-IN-5 (compound 5a) is a potent *p53-MDM2* inhibitor. p53-MDM2-IN-5 induces apoptosis, autophagy and DNA damage. p53-MDM2-IN-5 induces cell cycle arrest at S and G2/M phases. p53-MDM2-IN-5 shows anti-tumor activity .

HY-162927

*p53-MDM2-IN-6*	MDM-2/p53 Apoptosis	Cancer
p53-MDM2-IN-6 (Compound 10a), a LSM-83177 hydrazone analog, is a potent *p53-MDM2* inhibitor with an IC₅₀ value of 11.08 µg/mL. p53-MDM2-IN-6 arrests the cell cycle in the S phase and induces early and late Apoptosis with antiproliferative activity against HT29 cell lines with an IC₅₀ value of 10.44 µg/mL. p53-MDM2-IN-6 inhibits p53-MDM2 interaction with increment in p-53 level and decrease the expression of GST enzymes. p53-MDM2-IN-6 is promising for research of colorectal cancer .

HY-W340839

*p53-MDM2-IN-1*	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
p53-MDM2-IN-1 (Example 30) is an inhibitor of *p53-MDM2/X* protein interaction with an K_i value of 23.35 µM. p53-MDM2-IN-1 can be used for anti-tumor research .

HY-116052

*p53-MDM2-IN-2*	MDM-2/p53 NF-κB	Cancer
p53-MDM2-IN-2 (Compound 5q) is an orally active *p53-MDM2* inhibitor with a K_i value of 0.25 μM. p53-MDM2-IN-2 exerts antitumor activity by inhibiting NF-κB pathway .

HY-121893

*p53-MDM2-IN-3*	MDM-2/p53 NF-κB	Cancer
p53-MDM2-IN-3 (Compound 5s) is an orally active *p53-MDM2* inhibitor with a K_i value of 0.25 μM. p53-MDM2-IN-3 exerts antitumor activity by inhibiting NF-κB pathway .

HY-W340313

*p53-MDM2-IN-4*	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
p53-MDM2-IN-4 (Example 4) is an inhibitor of *p53-MDM2/X* protein interaction, with a K_i value of 3.079 μM. p53-MDM2-IN-4 can be used in anti-tumor research .

HY-14967

NSC 66811	MDM-2/p53	Cancer
NSC 66811 is a *MDM2-p53* inhibitor, with a K_i of 120 nM for binding to MDM2 .

HY-158684

YX-02-030	PROTACs MDM-2/p53	Cancer
YX-02-030M is a PROTAC *MDM2* degrader. YX-02-030M inhibits MDM2-p53 binding and VHL-HIF1α binding with IC₅₀s of 63 nM and 1.35 μM respectively. YX-02-030M binds MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, and effectively kills p53 mutant or deleted Triple-negative breast cancers (TNBC) cells. (Blue: VHL ligand; Black: linker; Pink: MDM2 inhibitor) .

HY-134823

MD-222	MDM-2/p53 PROTACs E1/E2/E3 Enzyme	Cancer
MD-222 is the first-in-class highly potent PROTAC degrader of *MDM2. MD-222 consists of ligands for Cereblon* and *MDM2. MD-222 induces rapid degradation of the MDM2* protein and activation of wild-type p53 in cells. MD-222 has anticancer effects ^[2].

HY-150620

BI-0282	MDM-2/p53	Cancer
BI-0282 (Compound 1) is a potent *MDM2-p53* interaction inhibitor .

HY-112816

MA242	MDM-2/p53 Apoptosis	Cancer
MA242 is a specific dual inhibitor of *MDM2* and NFAT1. MA242 directly binds both MDM2 and NFAT1 with high affinity, induces their protein degradation, and inhibits NFAT1-mediated transcription of MDM2. MA242 induces apoptosis in pancreatic cancer cell lines regardless of p53 status .

HY-146806

YL93	MDM-2/p53	Cancer
YL93 is a dual inhibitors of *MDM2/4* with K_i values of 0.64 μM and 1.1 nM for MDM4 and MDM2, respectively. YL93 induces cell-cycle arrest and apoptosis. YL93 shows p53-dependent cell growth inhibition .

HY-112816A

MA242 free base	MDM-2/p53 Apoptosis	Cancer
MA242 free base is a specific dual inhibitor of *MDM2* and NFAT1. MA242 free base directly binds both MDM2 and NFAT1 with high affinity, induces their protein degradation, and inhibits NFAT1-mediated transcription of MDM2. MA242 free base induces apoptosis in pancreatic cancer cell lines regardless of p53 status .

HY-117585

Caylin-2	MDM-2/p53	Cancer
Caylin-2, a Nutlin-3 analog, is a *MDM2* inhibitor. Caylin-2 can bind to Bcl-X_L .

HY-15335

Nutlin-3b	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
Nutlin-3b, the inactive form of Nutlin-3 (HY-50696), is a *p53/MDM2* inhibitor with an IC₅₀ of 13.6 μM. Nutlin-3b is 150 times less potent in binding to *MDM2* than Nutlin-3a (HY-10029). Nutlin-3b is promising for research of cancers ^[2] .

HY-15676

Idasanutlin 35+ Cited Publications RG7388	MDM-2/p53 E1/E2/E3 Enzyme	Cancer
Idasanutlin (RG7388) is a potent and selective *MDM2* antagonist, inhibiting p53-MDM2 binding, with an IC₅₀ of 6 nM.

Cat. No.	Product Name

HY-L128

E3 Ligase Ligand Library

52 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation.

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 52 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L003

Apoptosis Compound Library

2,352 compounds

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease.

MCE designs a unique collection of 2,352 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

HY-L109

Protein-protein Interaction Inhibitor Library

587 compounds

Protein protein interactions (PPI) have pivotal roles in life processes. The studies showed that aberrant PPI are associated with various diseases, including cancer, infectious diseases, and neurodegenerative diseases. The classic drug targets are usually enzymes, ion channels, or receptors, the PPI indicate new potential therapeutic targets. Therefore, targeting PPI is a new direction in treating diseases and an essential strategy for the development of new drugs.

However, the design of modulators targeting PPI still faces tremendous challenges, such the difficult PPI interfaces for the drug design, lack of ligands reference, lack of guidance rules for the PPI modulators development and high-resolution PPI proteins structures.

With the development of high-throughput technology, high-throughput screening is also gradually used for the identification of PPI inhibitors, but the compound library used for conventional target screening is not very effective in screening PPI inhibitors. To improve screening efficiency, MCE carefully selected 587 PPI inhibitors and mainly targeting MDM2-p53, Keap1-Nrf2, PD-1/PD-L1, Myc-Max, etc. MCE Protein-protein Interaction Inhibitor Library is a useful tool for PPI drug discovery and related research.

Cat. No.	Product Name	Type

HY-W008907

5'-O-Tritylthymidine 5-OTT	Gene Sequencing and Synthesis
5'-O-Tritylthymidine is an inhibitor of *TK-2* and inhibits angiogenesis . 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.

Cat. No.	Product Name	Target	Research Area

HY-P4210

Sulanemadlin ALRN-6924; MP-4897	MDM-2/p53	Cancer
Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research .

HY-P3509A

PNC-28 acetate	Peptides	Cancer
PNC-28 acetate is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 acetate can be used for pancreatic cancer research ^[2].

HY-P5930

HOXB7 8–25 MDM2 32-46	Ligands for E3 Ligase	Cancer
HOXB7 8–25 (MDM2 32-46) is an *MDM2*-derived peptide epitope and can elicit antigen-specifc and tumor-reactive CD4 ⁺ T cell responses .

HY-141584

ATSP-7041	MDM-2/p53	Cancer
ATSP-7041, a selective dual peptide inhibitor of *MDM2* and MDMX, effectively reactivates the p53 tumor suppressor pathway in a mechanism-dependent manner in p53-positive cancers .

HY-P10286

Phage-derived 12/1 peptide	MDM-2/p53	Cancer
Phage-derived 12/1 peptide exhibits antitumor activity by targeting *MDM2* and MDMX, an thus disrupt the MDM2-p53 and MDMX-p53 interaction, with IC₅₀ of 0.15 and 1.25 μM .

HY-P5367

5-FAM-PMDM6 PMDM6-F	Peptides	Others
5-FAM-PMDM6 (PMDM6-F) is a biological active peptide. (PMDM6-F is a fluorescent-labeled probe for MDM2-binding assay.)

HY-P1755

p53 (17-26)	MDM-2/p53	Cancer
p53 (17-26) is amino acids 17 to 26 fragment of p53. p53 (17-26) is mdm-2-binding domain .

HY-P3509

PNC-28	Peptides	Cancer
PNC-28 is a peptide from the mdm-2-binding domain (residues 17–26) of the p53 protein which contains a membrane crossing-penetratin sequence. PNC-28 can be used for pancreatic cancer research ^[2].

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701593

	MDM2 Protein, Human MDM2; E3 ubiquitin-protein ligase MDM2; Double minute 2 protein; Hdm2; Oncoprotein MDM2; RING-type E3 ubiquitin transferase MDM2; p53-binding protein MDM2	Human	E. coli
	MDM2 protein is a key E3 ubiquitin protein ligase that coordinates cellular processes by ubiquitinating and degrading p53/TP53 and inhibiting its tumor suppressor function. In addition to p53/TP53 regulation, MDM2 inhibits p53/TP53- and p73/TP73-mediated responses, self-ubiquitinates, and targets ARRB1 for degradation. MDM2 Protein, Human is the recombinant human-derived MDM2 protein, expressed by E. coli , with tag free. The total length of MDM2 Protein, Human is 95 a.a., with molecular weight of 11.1 kDa.

HY-P701594

	MDM2 Protein, Human (His) MDM2; E3 ubiquitin-protein ligase MDM2; Double minute 2 protein; Hdm2; Oncoprotein MDM2; RING-type E3 ubiquitin transferase MDM2; p53-binding protein MDM2	Human	E. coli
	MDM2 protein is a key E3 ubiquitin protein ligase that coordinates cellular processes by ubiquitinating and degrading p53/TP53 and inhibiting its tumor suppressor function. In addition to p53/TP53 regulation, MDM2 inhibits p53/TP53- and p73/TP73-mediated responses, self-ubiquitinates, and targets ARRB1 for degradation. MDM2 Protein, Human (His) is the recombinant human-derived MDM2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of MDM2 Protein, Human (His) is 95 a.a., .

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Cat. No.	Product Name	Chemical Structure

HY-153939S

Idasanutlin-d3-1
Idasanutlin-d₃-1 (RG7388-d₃-1) is the deuterium labeled Idasanutlin. Idasanutlin is a potent antagonist of *MDM2/p53*. Idasanutlin inhibits relapsed or refractory acute myeloid leukemia ^[2].

HY-12296S

Navtemadlin-d7
Navtemadlin-d₇ is the deuterium labeled Navtemadlin. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2].

HY-18986S

SAR405838-d10
SAR405838-d₁₀ (MI-77301-d₁₀) is the deuterium labeled SAR405838 (HY-18986). SAR405838 (MI-77301), an analog of MI-773, is a highly potent and selective *MDM2-p53* interaction inhibitor. SAR405838 binds to MDM2 with a K_i of 0.88 nM. SAR405838 induces apoptosis and has potent antitumor activity ^[2] .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83705

	MDM2 Antibody (YA3442) ACTFS antibody; Double minute 2 protein antibody; E3 ubiquitin-protein ligase MDM2 antibody; Hdm 2 antibody; Hdm2 antibody; HDMX antibody; MDM 2 antibody; MDM2 antibody; MDM2 oncogene E3 ubiquitin protein ligase antibody; MDM2 p53 E3 ubiquitin protein ligase homolog antibody; MDM2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody; MDM2_HUMAN antibody; MDM2BP antibody; Mouse Double Minute 2 antibody; MTBP antibody; Murine Double Minute Chromosome 2 antibody; Oncoprotein MDM2 antibody; p53 Binding Protein MDM2 antibody; p53-binding protein MDM2 antibody; Ubiquitin protein ligase E3 MDM2 antibody; Ubiquitin protein ligase E3 MDM2 antibody	WB, IHC-P, ICC/IF	Human, Monkey
	MDM2 Antibody (YA3442) is a mouse-derived non-conjugated IgG1 antibody (Clone NO.: YA3442), targeting MDM2, with a predicted molecular weight of 55 kDa (observed band size: 90 kDa). MDM2 Antibody (YA3442) can be used for WB, ICC/IF, IHC-P experiment in human, monkey background.

HY-P82143

	*Phospho-MDM2* (Ser166) Antibody (YA1888)** Double minute 2 protein; Hdm2; Oncoprotein MDM2	WB, IHC-P	Human, Rat
	Phospho-MDM2 (Ser166) Antibody (YA1888) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1888), targeting Phospho-MDM2 (Ser166), with a predicted molecular weight of 55 kDa (observed band size: 90 kDa). Phospho-MDM2 (Ser166) Antibody (YA1888) can be used for WB, IHC-P experiment in human, rat background.

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HY-128832

Nutlin-C1-amido-PEG4-C2-N3 MDM2 Ligand-Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 48		Azide
Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology. Nutlin-C1-amido-PEG4-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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