Search Result

Results for "

R1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (1) Adenosine Receptor (2) Adenylate Cyclase (1) Akt (3) Amino Acid Derivatives (6) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (5) Apoptosis (16) Aurora Kinase (2) Autophagy (2) Bacterial (5) Bcr-Abl (1) Biochemical Assay Reagents (9) c-Fms (27) c-Kit (3) Cannabinoid Receptor (1) Caspase (2) CDK (1) COX (2) CRFR (2) DNA/RNA Synthesis (1) E3 Ligase Ligand-Linker Conjugates (1) EGFR (3) Endogenous Metabolite (4) ERK (1) FAK (1) FGFR (2) FLT3 (1) Fluorescent Dye (2) GCGR (34) GHSR (7) GLP Receptor (33) Glucosidase (1) Glycosyltransferase (1) HDAC (1) Histamine Receptor (3) Histone Demethylase (1) HIV (1) ICMT (1) IGF-1R (29) Imidazoline Receptor (3) Influenza Virus (1) Insulin Receptor (10) Interleukin Related (5) Isotope-Labeled Compounds (6) JNK (1) LPL Receptor (3) MCHR1 (GPR24) (8) Melanocortin Receptor (4) Mitochondrial Metabolism (1) Monoamine Oxidase (1) Neurokinin Receptor (6) Neuropeptide FF Receptor (1) NF-κB (2) Opioid Receptor (2) Orexin Receptor (OX Receptor) (4) Parasite (3) PARP (1) PDGFR (5) PI3K (2) Prostaglandin Receptor (1) PROTAC Linkers (1) PTHR (1) Pyk2 (1) Ras (2) Reactive Oxygen Species (2) RIP kinase (1) ROR (1) ROS Kinase (1) Small Interfering RNA (siRNA) (21) Somatostatin Receptor (1) Src (2) STAT (1) Tau Protein (1) TNF Receptor (1) Trk Receptor (1) TSH Receptor (1) Vasopressin Receptor (1) VEGFR (6)
By Research Areas:	Cancer (80) Cardiovascular Disease (9) Endocrinology (30) Infection (9) Inflammation/Immunology (27) Metabolic Disease (72) Neurological Disease (33)
Click Chemistry:	Azide (3)
Oligonucleotides:	Pre-designed siRNA Sets (21) Antisense Oligonucleotides (2) siRNAs (21)

265

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

116

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126719

R-1 Methanandamide Phosphate	Others	Neurological Disease
R-1 Methanandamide Phosphate is a water-soluble prodrug analog of arachidonylethanolamide (AEA). AEA is an endogenous cannabinoid compound ^[1].

HY-137453C

*(R,1R)-Tenofovir amibufenamide* (R,1R)-HS-10234	Others	Others
(R,1R)-Tenofovir amibufenamide ((R,1R)-HS-10234) can be used for the purifying a tenofovir prodrug. Tynofovir (tenofovir) is a nucleoside acids reverse transcriptase inhibitors ^[1].

HY-W002295

*(R)-1-Amino-2-propanol*	Biochemical Assay Reagents	Others
(R)-1-aminopropan-2-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-77490

*(R)-(-)-1,3-Butanediol*	Endogenous Metabolite	Metabolic Disease
(R)-(-)-1,3-Butanediol is used to regulate the metabolism of carbohydrate and lipid.

HY-40041

*(R)-1-Boc-3-methyl-piperazine*	Biochemical Assay Reagents	Others
(R)-1-Boc-3-methyl-piperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-149715

R1-11	ICMT	Cancer
R1-11 is an indole ICMT inhibitor with an IC₅₀ of 0.6 μM and has anticancer activity. R1-11 inhibits MDA-MB231 and PC3 cells with IC₅₀s of 2.2 μM and 2.0 μM, respectively ^[1].

HY-W017610

*(R)-1-Phenyl-2-propanol*	Others	Others
(R)-1-Phenyl-2-propanol is a chiral alcohol. (R)-1-Phenyl-2-propanol can be converted from (S)-1-phenyl-2-propanol ^[1] .

HY-W061650

*(R)-1-Benzylpyrrolidine-2-carboxylic acid*	Amino Acid Derivatives	Others
(R)-1-Benzylpyrrolidine-2-carboxylic acid is a proline derivative ^[1].

HY-40022

*(R)-1-Boc-3-Hydroxypiperidine*	Biochemical Assay Reagents	Others
(R)-1-Boc-3-Hydroxypiperidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-40097

*(R)-1-Boc-3-aminopyrrolidine*	Biochemical Assay Reagents	Others
(R)-1-Boc-3-aminopyrrolidine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-Z0031

*(R)-(-)-1,2-Propanediol*	Endogenous Metabolite	Metabolic Disease
(R)-(-)-1,2-Propanediol is a (R)-enantiomer of 1,2-Propanediol that produced from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes ^[1].

HY-111825A

*(R)-1-PeCSO* Isoalliin; trans-(+)-S-1-Propenyl-L-cysteine sulfoxide	Others	Others
(R)-1-PeCSO (trans-(+)-S-1-Propenyl-L-cysteine sulfoxide) is the most abundant flavor precursor in onions ^[1].

HY-I0718

*(R)-1,1'-Binaphthyl-2,2'-diyl hydrogenphosphate*	Biochemical Assay Reagents	Others
(R)-(-)-1,1'-Binaphthyl-2,2'-diyl Hydrogenphosphate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-167705

(R)-7,7'-Dihydrotaiwanin C (R)-1,4-Dihydrotaiwanin C	Others	Others
(R)-7,7'-Dihydrotaiwanin C ((R)-1,4-Dihydrotaiwanin C) is a compound that exhibits significant biological activity.

HY-13987

*(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid* D-phenylalanine analogue	Others	Others
(R)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid is a constrained Phe analogue which can fold into a beta-bend and a helical structure, and to adopt a preferred side-chain disposition in the peptide.

HY-N0615

Notoginsenoside R1 2 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Amyloid-β Apoptosis	Others
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells ^[1] .

HY-N0615R

Notoginsenoside R1 (Standard)	Amyloid-β Apoptosis	Others
Notoginsenoside R1 (Standard) is the analytical standard of Notoginsenoside R1. This product is intended for research and analytical applications. Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells ^[1] .

HY-N6924

Zingibroside R1	HIV	Infection Metabolic Disease
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity ^[1]. Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM) .

HY-N12533

Quinquenoside R1	Others	Others
Quinquenoside R1 (Compound 12) is a saponin compound that can be isolated from wild ginseng ^[1].

HY-N7025

Suavissimoside R1	Others	Neurological Disease
Suavissimoside R1, isolated from the roots of Rubus parvifollus, possesses potent neuroprotective activity and has the potential to treat anti-Parkinson's disease agent ^[1].

HY-100308

SB-568849	MCHR1 (GPR24)	Metabolic Disease Endocrinology
SB-568849 is a melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pK_i of 7.7.

HY-162872

NBI-35965	CRFR	Neurological Disease
NBI-35965 is an antagonist of corticotropin-releasing factor receptor 1 (CRF-R1). NBI-35965 can be used in nervous system related research ^[1].

HY-151279

ALK5-IN-30	Anaplastic lymphoma kinase (ALK)	Cancer
ALK5-IN-30 (EX-07) is a potent ALK inhibitor, inhibits ALK5 and TGFβ-R1 with both IC₅₀s <10 nM ^[1].

HY-11083

GW-803430 GW-3430	MCHR1 (GPR24)	Metabolic Disease
GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC₅₀ of 9.3. GW-803430 is orally active in an animal model of obesity ^[1].

HY-169084

ST-IN-1	Glycosyltransferase	Cancer
ST-IN-1 (compound (R)-1) is a selective ST inhibitor (K_i=70 nM, rat a-2,6-ST; K_i=19 nM, *hST6GAL1*) with antitumor activity. ST-IN-1 inhibits tumor growth and metastasis by delipidating the surface of tumor cells ^[1].

HY-149409

α-Glucosidase-IN-31	Glucosidase	Metabolic Disease
α-Glucosidase-IN-31 (compound R1) is an orally active, potent α-Glucosidase inhibitor with an IC₅₀ value of 10.1 μM. α-Glucosidase-IN-31 significantly reduces the blood glucose level and has antidiabetic activity ^[1].

HY-P3959

(Tyr0)-Urocortin, rat	CRFR	Endocrinology
(Tyr0)-Urocortin, rat is a high-affinity agonist of corticotropin-releasing factor receptor type 1 (CRF-R1) and type 2 (CRF-R2). (Tyr0)-Urocortin, rat shows inhibitory binding constants (Ki) of 1-2 nM ^[1].

HY-116031

ATC0175 free base	MCHR1 (GPR24)	Metabolic Disease
ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC₅₀ value of 3.4 nM, as well as good selectivity over the Y5 and the α_2A receptors. ATC0175 (free base) is promising for research of obesity ^[1].

HY-163805

UNC10245380	ERK TNF Receptor Akt	Cancer
UNC10245380 is a *CIB1* inhibitor with an IC₅₀ value of 8 μM. Additionally, UNC10245380 inhibits the phosphorylation of AKT and ERK and upregulates the expression of *TRAIL-R1/D5. UNC10245380 selectively induces cell death in CIB1*-dependent cancer cells, highlighting its potential utility in the development of CIB1-targeted probes and cancer research ^[1] .

HY-18187

Ki 23057	Apoptosis	Cancer
Ki 23057 is a competitive, orally active inhibitor for tyrosine kinase, which inhibits the phosphorylation of K-samII/FGF-R2, VEGF-R1, VEGF-R2, PDGF-Rβ and c-Kit, with IC₅₀s of 88, 69, 83, 100 and 480 nM. Ki 23057 inhibits the proliferation of sclerogastric cancer cells OCUM-2MD3 and OCUM-8, and induces apoptosis. Ki 23057 exhibits antitumor efficacy in mouse models ^[1].

HY-P1110

AF12198 1 Publications Verification	Interleukin Related	Inflammation/Immunology
AF12198 is a potent, selective and specific peptide antagonist for human type I interleukin-1 receptor (IL1-R1) (IC₅₀=8 nM) but not the human type II receptor (IC₅₀=6.7 µM) or the murine type I receptor (IC₅₀>200 µM). AF12198 inhibits IL-1-induced IL-8 production (IC₅₀=25 nM) and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression (IC₅₀=9 nM) in vitro. AF12198 has anti-inflammatory activities and blocks responses to IL-1 in vivo ^[1].

HY-108501

*(1R,1'S,3'R/1R,1'R,3'S)-L-054,264*	Somatostatin Receptor	Neurological Disease
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective non-peptide human somatostatin receptor subtype 2 (sst₂) agonist. (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can be used in the study of retinal neuromodulation ^[1] .

HY-W002530A

(1R,2R)-1-Aminoindan-2-ol	Biochemical Assay Reagents	Others
(1R,2R)-1-Aminoindan-2-ol is the isomer of (1S,2R)-1-Aminoindan-2-ol (HY-W002530), and can be used as an experimental control. (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W061614

(4R)-1-Boc-4-fluoro-D-proline	Amino Acid Derivatives	Others
(4R)-1-Boc-4-fluoro-D-proline is an amino acid derivative that can be used for preparation of peptidomimetics, dihydropyridopyrimidines and pyridopyrimidines ^[1] .

HY-W002530

(1S,2R)-1-Aminoindan-2-ol	Biochemical Assay Reagents	Others
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-RS00337

ADCYAP1R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ADCYAP1R1 Human Pre-designed siRNA Set A contains three designed siRNAs for ADCYAP1R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ADCYAP1R1 Human Pre-designed siRNA Set A ADCYAP1R1 Human Pre-designed siRNA Set A

HY-RS02206

CD200R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CD200R1 Human Pre-designed siRNA Set A contains three designed siRNAs for CD200R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CD200R1 Human Pre-designed siRNA Set A CD200R1 Human Pre-designed siRNA Set A

HY-RS02387

CDK5R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDK5R1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDK5R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDK5R1 Human Pre-designed siRNA Set A CDK5R1 Human Pre-designed siRNA Set A

HY-RS06710

IL18R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL18R1 Human Pre-designed siRNA Set A contains three designed siRNAs for IL18R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL18R1 Human Pre-designed siRNA Set A IL18R1 Human Pre-designed siRNA Set A

HY-RS06720

IL1R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL1R1 Human Pre-designed siRNA Set A contains three designed siRNAs for IL1R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL1R1 Human Pre-designed siRNA Set A IL1R1 Human Pre-designed siRNA Set A

HY-RS03419

CYB5R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CYB5R1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYB5R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CYB5R1 Human Pre-designed siRNA Set A CYB5R1 Human Pre-designed siRNA Set A

HY-RS03466

CYP2R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CYP2R1 Human Pre-designed siRNA Set A contains three designed siRNAs for CYP2R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CYP2R1 Human Pre-designed siRNA Set A CYP2R1 Human Pre-designed siRNA Set A

HY-RS07875

Ltb4r1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ltb4r1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ltb4r1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ltb4r1 Mouse Pre-designed siRNA Set A Ltb4r1 Mouse Pre-designed siRNA Set A

HY-RS10536

PIK3R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIK3R1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIK3R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIK3R1 Human Pre-designed siRNA Set A PIK3R1 Human Pre-designed siRNA Set A

HY-RS10635

PLA2R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PLA2R1 Human Pre-designed siRNA Set A contains three designed siRNAs for PLA2R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PLA2R1 Human Pre-designed siRNA Set A PLA2R1 Human Pre-designed siRNA Set A

HY-RS14212

TAS1R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TAS1R1 Human Pre-designed siRNA Set A contains three designed siRNAs for TAS1R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TAS1R1 Human Pre-designed siRNA Set A TAS1R1 Human Pre-designed siRNA Set A

HY-RS14215

TAS2R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TAS2R1 Human Pre-designed siRNA Set A contains three designed siRNAs for TAS2R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TAS2R1 Human Pre-designed siRNA Set A TAS2R1 Human Pre-designed siRNA Set A

HY-RS11026

PPP3R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PPP3R1 Human Pre-designed siRNA Set A contains three designed siRNAs for PPP3R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PPP3R1 Human Pre-designed siRNA Set A PPP3R1 Human Pre-designed siRNA Set A

HY-RS11029

PPP4R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PPP4R1 Human Pre-designed siRNA Set A contains three designed siRNAs for PPP4R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PPP4R1 Human Pre-designed siRNA Set A PPP4R1 Human Pre-designed siRNA Set A

HY-RS11034

PPP6R1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PPP6R1 Human Pre-designed siRNA Set A contains three designed siRNAs for PPP6R1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PPP6R1 Human Pre-designed siRNA Set A PPP6R1 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-77490

*(R)-(-)-1,3-Butanediol*	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R)-(-)-1,3-Butanediol is used to regulate the metabolism of carbohydrate and lipid.

HY-Z0031

*(R)-(-)-1,2-Propanediol*	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
(R)-(-)-1,2-Propanediol is a (R)-enantiomer of 1,2-Propanediol that produced from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes ^[1].

HY-111825A

*(R)-1-PeCSO* Isoalliin; trans-(+)-S-1-Propenyl-L-cysteine sulfoxide	Structural Classification Liliaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Allium cepa L. Plants Disease Research Fields	Others
(R)-1-PeCSO (trans-(+)-S-1-Propenyl-L-cysteine sulfoxide) is the most abundant flavor precursor in onions ^[1].

HY-N0615

Notoginsenoside R1 2 Publications Verification Sanchinoside R1; Sanqi glucoside R1	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Terpenoids Source classification Other Diseases Plants Disease Research Fields Araliaceae	Amyloid-β Apoptosis
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H₂O₂-induced oxidative damage in PC12 cells ^[1] .

HY-N6924

Zingibroside R1	Infection Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Classification of Application Fields Source classification Panax japonicas C. A. Mey. Metabolic Disease Plants Disease Research Fields Saccharides Araliaceae	HIV
Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity ^[1]. Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC₅₀=91.3 μM) .

HY-N7025

Suavissimoside R1	Triterpenes Structural Classification other families Terpenoids Source classification Plants	Others
Suavissimoside R1, isolated from the roots of Rubus parvifollus, possesses potent neuroprotective activity and has the potential to treat anti-Parkinson's disease agent ^[1].

HY-P99265

Mapatumumab HGS-ETR1; Anti-Human TNFRSF10A Recombinant Antibody	Classification of Application Fields Disease Research Fields Cancer	Others
Mapatumumab (HGS-ETR1) is a fully human IgG1 agonistic monoclonal antibody that targets tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1). Mapatumumab can be used for the research of cancer ^[1].

HY-167705

(R)-7,7'-Dihydrotaiwanin C (R)-1,4-Dihydrotaiwanin C	Structural Classification Source classification Lignans Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu Phenylpropanoids Plants Araliaceae	Others
(R)-7,7'-Dihydrotaiwanin C ((R)-1,4-Dihydrotaiwanin C) is a compound that exhibits significant biological activity.

HY-N0615R

Notoginsenoside R1 (Standard)	Triterpenes Structural Classification Panax notoginseng (Burkill) F. H. Chen ex C. H. Chow Terpenoids Source classification Plants Araliaceae	Amyloid-β Apoptosis
Notoginsenoside R1 (Standard) is the analytical standard of Notoginsenoside R1. This product is intended for research and analytical applications. Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells ^[1] .

HY-N12533

Quinquenoside R1	Structural Classification Natural Products Source classification Panax vietnamensis Ha & Grushv. Plants Araliaceae	Others
Quinquenoside R1 (Compound 12) is a saponin compound that can be isolated from wild ginseng ^[1].

HY-W048510

Epiquinidine	Alkaloids Structural Classification other families Classification of Application Fields Source classification Other Diseases Quinoline Alkaloids Plants Disease Research Fields	Others
Epiquinidine, a quinine analogue, can be used as the *ggTas2r1* agonist. Epiquinidine activates ggTas2r1 at or beyond 10 µM ^[1].

HY-N0908

Ginsenoside Rg5 2 Publications Verification	Panax ginseng C. A. Meyer Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae Endocrinology	IGF-1R NF-κB COX
Ginsenoside Rg5 is the main component of Red ginseng and *IGF-1R* agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of *IGF-1* to IGF-1R (IC₅₀ about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-P99672

Istiratumab MM 141; MM-005	Classification of Application Fields Disease Research Fields Cancer	IGF-1R EGFR
Istiratumab (M-6495) is bispecific monoclonal antibody targeting *IGF-1R* and ErbB3. Istiratumab induces IGF-1R and ErbB3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers ^[1] .

HY-N0908R

Ginsenoside Rg5 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	IGF-1R NF-κB COX
Ginsenoside Rg5 (Standard) is the analytical standard of Ginsenoside Rg5. This product is intended for research and analytical applications. Ginsenoside Rg5 is the main component of Red ginseng and IGF-1R agonist. Ginsenoside Rg5 compets for the binding site of IGF-1R and blocks the binding of IGF-1 to IGF-1R (IC50 about 90 nM). Ginsenoside Rg5 also inhibits the mRNA expression of COX-2 via suppression of the DNA binding activities of NF-κB p65.

HY-P99245

Emactuzumab RG 7155; RO 5509554	Classification of Application Fields Disease Research Fields Cancer	c-Fms
Emactuzumab(RG 7155) is a specific monoclonal antibody that inhibits colonystimulating factor 1 receptor *(CSF1R)* activation. Emactuzumab has high affinity for CSF-1R with K_i value of 0.2 nM to blocks CSF-1R dimerization. Emactuzumab can be used for the research of several diseases, such as diffuse-type tenosynovial giant cell tumour (dt-GCT) ^[1] .

HY-15494

Picropodophyllin Maximum Cited Publications 19 Publications Verification AXL1717; Picropodophyllotoxin; PPP	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Endocrinology	IGF-1R Apoptosis
Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC₅₀ of 1 nM.

HY-P99284

Dalotuzumab MK-0646; h7C10	Classification of Application Fields Disease Research Fields Cancer	IGF-1R Apoptosis
Dalotuzumab (MK-0646) is a recombinant humanized monoclonal antibody (IgG1 type) targeting *IGF-1R. Dalotuzumab acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R* autophosphorylation, and Akt phosphorylation. Dalotuzumab also induces apoptosis and cycle arrest. Dalotuzumab in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab in vitro and in vivo ^[1] .

HY-W011978

N-Acetyl-L-tryptophan	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to *NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β* and the activation of *caspase-1*. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases ^[1] .

HY-P99452

Axatilimab SNDX-6352	Classification of Application Fields Disease Research Fields Cancer	c-Fms
Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to *CSF-1R*. Axatilimab can be used for the research of chronic graft versus host disease (cGVHD) and neoplastic diseases ^[1] .

HY-P99368

Lacnotuzumab MCS110; Anti-Human B7-H3	Classification of Application Fields Disease Research Fields Cancer	c-Fms
Lacnotuzumab (MCS110) is a neutralizing humanized IgG1/κ monoclonal antibody targeting *CSF-1* that prevents CSF-1 from activating the CSF-1R. Lacnotuzumab can be used for the research of pigmented villonodular synovitis ^[1] .

HY-P99218

Robatumumab Sch 717454; 19D12	Classification of Application Fields Disease Research Fields Cancer	IGF-1R
Robatumumab (Sch 717454) is an anti-human *IGF-1R* (insulin-like growth factor receptor-1) antibody. Robatumumab shows anti-tumor activity and anti-proliferative activity to cancer cells. Robatumumab can be used in osteosarcoma and Ewing sarcoma research ^[1] .

HY-N6611

Chimaphilin	Quinones Structural Classification Passifloraceae Source classification Passiflora incarnata L. Plants Naphthalene Quinones	IGF-1R
Chimaphilin is an *IGF-1R* inhibitor (IC₅₀: 0.086 μM). Chimaphilin has antifungal, antioxidant and anticancer activities. Chimaphilin inhibits the growth of both drug-sensitive and drug-resistant osteosarcoma cell lines. Chimaphilin can induce cancer cell apoptosis. Chimaphilin is a main component of pyrola ^[1] .

Cat. No.	Product Name	Chemical Structure

HY-W004356S

(Rac)-Tenofovir alafenamide-d5
(2R)-Isopropyl 2-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate-d5 is the deuterium labeled (2R)-isopropyl 2-((((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)amino)propanoate ^[

HY-A0052S

(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d4
(1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide-d₄ is deuterated labeled (1S,3aR,6aS)-(2S)-2-Cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1R)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydrocyclopenta[c]pyrrole-1-carboxamide.

HY-Z4561S

Bortezomib trimer-d15
Bortezomib trimer-d₁₅ is deuterium labeled N,N',N''-((2S,2'S,2''S)-(((1R,1'R,1''R)-(1,3,5,2,4,6-Trioxatriborinane-2,4,6-triyl)tris(3-methylbutane-1,1-diyl))tris(azanediyl))tris(1-oxo-3-phenylpropane-1,2-diyl))tris(pyrazine-2-carboxamide)（Bortezomib Impurity）.

HY-B0374S1

Moxonidine-d7
Moxonidine-d₇ is deuterated labeled Moxonidine (HY-B0374). Moxonidine (BDF5895) is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.

HY-B0374AS

Moxonidine-13C,d3 hydrochloride
Moxonidine- ¹³C,d₃ hydrochloride is ¹³C and deuterated labeled Moxonidine hydrochloride (HY-B0374A). Moxonidine (BDF5895) hydrochloride is an imidazoline type 1 receptor (I1-R) selective agonist and antihypertensive agent.

HY-15494S1

Picropodophyllin-d6
Picropodophyllin-d₆ (AXL1717-d₆) is deuterium labeled Picropodophyllin. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.

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