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metalation

" in MedChemExpress (MCE) Product Catalog:

360

Inhibitors & Agonists

1

Screening Libraries

25

Fluorescent Dye

108

Biochemical Assay Reagents

27

Peptides

37

Natural
Products

16

Isotope-Labeled Compounds

7

Click Chemistry

10

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D0179

    Biochemical Assay Reagents Infection Cardiovascular Disease
    Cyclam is a metal chelator that forms metal complexes with a variety of metal ions. Cyclam metal complexes exhibits anti-HIV (such as AMD3100), nitric oxide (NO) releasing and scavenging (such as Zn(II)-Cyclam and Ru(II)-Cyclam), and SOD mimetic (such as Mn(III)-Cyclam and Zn(II)-Cyclam) activities .
    Cyclam
  • HY-P3320

    PC 3

    Biochemical Assay Reagents Others
    Phytochelatin 3 (PC 3) is the small metal chelating peptide that can be used for chelating heavy metals .
    Phytochelatin 3
  • HY-W012683

    Biochemical Assay Reagents Cancer
    Iminodiacetic acid is a metal ion chelator targeting Cr 6+, Cd 2+, Ni 2+, and Pb 2+. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .
    Iminodiacetic acid
  • HY-136941

    MD 1024

    Biochemical Assay Reagents Others
    Antioxidant 1024 (MD 1024) is an antioxidant agent and metal deactivator .
    Antioxidant 1024
  • HY-128370

    Ca-DTPA trisodium salt hydrate

    CMV Infection
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication .
    Calcium trinatrium diethylenetriaminepentaacetic acid hydrate
  • HY-B1335

    Diethylenetriaminepentaacetic acid; DTPA

    Fluorescent Dye Others
    Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide .
    Pentetic acid
  • HY-W014230

    Others Others
    1,4-Bis(trifluoromethyl)benzene is an organic compound of great significance in the study of metalation reactions in organic synthesis .
    1,4-Bis(trifluoromethyl)benzene
  • HY-16739

    NBMI; BDTH2

    Cuproptosis Reactive Oxygen Species Inflammation/Immunology Cancer
    Emeramide is a thiol-redox antioxidant and heavy metal chelator .
    Emeramide
  • HY-P3322

    PC 5

    Biochemical Assay Reagents Others
    Phytochelatin 5 is metal-binding compound produced by plants. Phytochelatin 5 may reduce bioavailability of dietary toxic metals such as cadmium .
    Phytochelatin 5
  • HY-121514

    MMP Others
    Talopeptin is a metal protease inhibitor that can be produced by the streptomyces MK-23 .
    Talopeptin
  • HY-P3323

    PC 6

    Biochemical Assay Reagents Others
    Phytochelatin 6 is metal-binding compound produced by plants. Phytochelatin 6 may reduce bioavailability of dietary toxic metals such as cadmium .
    Phytochelatin 6
  • HY-W087962

    Insecticide Others
    Phenylphosphonic acid (Compound 1) is a synthetic pyrethroid insecticide that can effectively control some underground pests. Phenylphosphonic acid also can be a ligand in some metal-catalyzed reactions, which is promising for research of metal phosphonates comprising layered structures and pesticides .
    Phenylphosphonic acid
  • HY-D0261
    Tiron
    1 Publications Verification

    Biochemical Assay Reagents Apoptosis Metabolic Disease Inflammation/Immunology Cancer
    Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals .
    Tiron
  • HY-P3322A

    PC 5 TFA

    Endogenous Metabolite Others
    Phytochelatin 5 TFA is metal-binding compound produced by plants. Phytochelatin 5 TFA may reduce bioavailability of dietary toxic metals such as cadmium .
    Phytochelatin 5 TFA
  • HY-P3323A

    PC 6 TFA

    Biochemical Assay Reagents Others
    Phytochelatin 6 TFA is metal-binding compound produced by plants. Phytochelatin 6 TFA may reduce bioavailability of dietary toxic metals such as cadmium .
    Phytochelatin 6 TFA
  • HY-136941R

    Biochemical Assay Reagents Others
    Antioxidant 1024 (Standard) is the analytical standard of Antioxidant 1024. This product is intended for research and analytical applications. Antioxidant 1024 (MD 1024) is an antioxidant agent and metal deactivator .
    Antioxidant 1024 (Standard)
  • HY-D1641

    Fluorescent Dye Others
    5,5'-Dimethyl BAPTA tetrapotassium is a water-soluble, extracellular membrane metal chelator with relative selectivity for calcium ions .
    5,5'-Dimethyl BAPTA tetrapotassium
  • HY-W175580

    Fluorone black

    Biochemical Assay Reagents Others
    Phenylfluorone (Fluorone black) can be used for photometric determination of some heavy metals, such as Germanium and Tin .
    Phenylfluorone
  • HY-W087043

    N-phenylallylamine; N-Allyl-N-phenylamine

    Biochemical Assay Reagents Others
    N-Allylaniline (N-phenylallylamine) is an aromatic amine that acts as a metal complex .
    N-Allylaniline
  • HY-Y0102

    2-Mercaptobenzoic acid

    Biochemical Assay Reagents Others
    Thiosalicylic acid (2-Mercaptobenzoic acid) is a stabilizer that can be used in the synthesis of metal nanoparticles. Thiosalicylic acid is a biomaterial or organic compound that can be used in life science research .
    Thiosalicylic acid
  • HY-D1746

    EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester

    Biochemical Assay Reagents Others
    EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
    EDTA-AM
  • HY-P10510

    Biochemical Assay Reagents Others
    R5 peptide is one of the repeating peptide sequences that form the protein diatom in Cylindrotheca fusiformis. R5 peptide can be used as a template for the synthesis of Pd (palladium) nanoparticles (NPs). R5 peptide forms complexes with metal ions through the amine groups in its sequence, and the self-assembled structure of the peptide provides a confined spatial environment for the reduction of metal ions and the nucleation of nanoparticles. R5 peptide can be used in the research of biomimetic nanomaterials .
    R5 peptide
  • HY-B1335R

    Fluorescent Dye Others
    Pentetic acid (Standard) is the analytical standard of Pentetic acid. This product is intended for research and analytical applications. Pentetic acid is a compound used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater .
    Pentetic acid (Standard)
  • HY-W151206

    Fluorescent Dye Others
    Hydroxy naphthol blue disodium, an azo dye, is a metal indicator for calcium and a colorimetric reagent for alkaline earth metal ions ( λmax = 650 nm). In the pH range between 12 and 13, the solution of the indicator is reddish pink in the presence of calcium ion and to deep blue in the presence of disodium EDTA .
    Hydroxy naphthol blue disodium
  • HY-164854

    Biochemical Assay Reagents Others
    (R)-DOTAGA2 (Compound 7) is a metal chelate ligand. (R)-DOTAGA2 can be used to evaluate blood volume changes in the heart and brain .
    (R)-DOTAGA2
  • HY-137296
    Lumogallion
    1 Publications Verification

    Fluorescent Dye Others
    Lumogallion is a highly sensitive fluorescent reagent for the detection of aluminum, gallium and other metals. Lumogallion has an excitation wavelength of 490 nm and an emission spectrum in the range of 520 nm to 650 nm, with a peak near 580 nm .
    Lumogallion
  • HY-147962

    Cholinesterase (ChE) HDAC Neurological Disease
    COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research .
    AChE/HDAC-IN-1
  • HY-Y0032

    Orthopoxvirus Infection Others Cancer
    Thiosemicarbazide is a vitamin B6 antagonist with anti-acne activity. Thiosemicarbazide is also a well-known source in the synthesis of heterocycles, and its derivatives have potential anticancer activity. Thiosemicarbazide (TSC: HL1) reacts with metal salts, urea (U), to prepare Co(II) and Cu(I) metal complexes. Thiosemicarbazide is also used in the fields of media communications and optical storage, and in the spectrophotometric detection of metals .
    Thiosemicarbazide
  • HY-122507

    A 28695A; Antibiotic A 28695A

    Antibiotic Infection
    Septamycin (A 28695A) is a metal complexing polyether antibiotic. Septamycin is produced by a strain of Streptomyces hygroscopicus NRRL 5678. Septamycin has anticoccidial activity .
    Septamycin
  • HY-149820

    Monoamine Oxidase Neurological Disease
    MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC50 of 0.014 μM. MAO-B-IN-22 has high antioxidant activity, good metal chelating ability, proper BBB permeability and significant neuroprotective effect .
    MAO-B-IN-22
  • HY-W076836

    p-aminobenzaldehyde

    Biochemical Assay Reagents Others
    4-Aminobenzaldehyde (p-aminobenzaldehyde) is a useful synthetic reagent and monomer that can be used to synthesize monoazo dyes and photocurable ion exchange resins. 4-Aminobenzaldehyde is also a corrosion inhibitor of metals .
    4-Aminobenzaldehyde
  • HY-126302
    DMT1 blocker 2
    2 Publications Verification

    Ferroportin Metabolic Disease
    DMT1 blocker 2 is a direct inhibitor of divalent metal transporter 1 (DMT1), with an IC50 of 0.83 μM. DMT1 blocker 2 can block iron uptake by enterocytes in vivo .
    DMT1 blocker 2
  • HY-116454

    Reverse Transcriptase HIV Infection
    GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC50 value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism .
    GSK5750
  • HY-W009906

    Aminopeptidase Inflammation/Immunology
    2-(2’-Pyridyl)benzimidazole is a potentially tridentate ligand that can form stable complexes with various transition metal ions. 2-(2’-Pyridyl)benzimidazole can be used as an anti-inflammatory agent and an inhibitor of Escherichia coli methionine aminopeptidase .
    2-(2′-Pyridyl)benzimidazole
  • HY-N4084

    Apoptosis Cancer
    Thonningianin A, an ellagitannin, is isolated from the methanolic extract of the African medicinal herb, Thonningia sanguinea. The antioxidant properties of Th A involve radical scavenging, anti-superoxide formation and metal chelation. Anti-cancer activities .
    Thonningianin A
  • HY-W013205

    Biochemical Assay Reagents Others
    Bis(4-nitrophenyl) phosphate is a catalyst for metal micelles and can catalyze the hydrolysis of (4-nitrophenyl) phosphate. Bis(4-nitrophenyl) phosphate is also an effective catalyst for ring-opening polymerization (ROP), which can achieve controlled polymerization of β-butyrolactone (β-BL) ring-opening and can be used to prepare diembedded polymers without quenching. segment copolymer .
    Bis(4-nitrophenyl) phosphate
  • HY-162402

    Reactive Oxygen Species Cholinesterase (ChE) Cancer
    NLRP3-IN-33 (Compound 12o) is a blood-brain barrier permeable inhibitor of AChE and BChE, with IC50 values of 1.02 μM and 7.03 μM against hAChE and hBChE respectively. NLRP3-IN-33 possesses antioxidant, anti-inflammatory, and metal chelating activities, making it a potential candidate for research in Alzheimer's disease (AD) .
    NLRP3-IN-33
  • HY-156403

    Topoisomerase Cancer
    AuM1Phe, an N-Heterocyclic carbene (NHC) metal complexe, blocks the human topoisomerase I activity and actin polymerization reaction. AuM1Phe affects the growth of MDA-MB-231 breast cancer cells, with an IC50 value of 1.2 μM .
    AuM1Phe
  • HY-W013205R

    Biochemical Assay Reagents Others
    Bis(4-nitrophenyl) phosphate (Standard) is the analytical standard of Bis(4-nitrophenyl) phosphate. This product is intended for research and analytical applications. Bis(4-nitrophenyl) phosphate is a catalyst for metal micelles and can catalyze the hydrolysis of (4-nitrophenyl) phosphate. Bis(4-nitrophenyl) phosphate is also an effective catalyst for ring-opening polymerization (ROP), which can achieve controlled polymerization of β-butyrolactone (β-BL) ring-opening and can be used to prepare diembedded polymers without quenching. segment copolymer .
    Bis(4-nitrophenyl) phosphate (Standard)
  • HY-170583

    Cholinesterase (ChE) Amyloid-β Neurological Disease
    hAChE-IN-10 (Compound ET11) is the inhibitor for human acetylcholinesterase (AChE) with an IC50 of 6.34 nM. hAChE-IN-10 scavenges free radicals, and exhibits antioxidant activity. hAChE-IN-10 exhibits metal chelating activity, inhibits Cu 2+-induced Aβ1-42 aggregation, reduces the formation of amyloid plaques, and exhibits neuroprotective activity. hAChE-IN-10 ameliorates the Scopolamine (HY-N0296)-induced cognitive impairment in mouse models .
    hAChE-IN-10
  • HY-P3566

    Biochemical Assay Reagents Others
    (D-Lys16)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the reaction product with gadolinium tetraazacyclododecanetriacetate derivative. (D-Lys16)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) involves in preparation of tetraazacyclododecane macrocycle metal complexes for production of conjugates with biomolecules and for use as NMR contrast agents, radiodiagnostic agents and for radioresearch .
    (D-Lys16)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
  • HY-W115738

    Biochemical Assay Reagents Others
    PAR is an azo dye widely used as a colorimetric reagent for metal ions. PAR forms stable chelates with different metal ions. PAR can also complex with heavy metal ions in polar organic solvent like ethanol .
    PAR
  • HY-W134020

    Semixylenol orange

    Biochemical Assay Reagents Others
    Semixylenol orange is a metallochromic indicator that can complex with various metal ions and is used for the testing and analysis of metal ions such as zinc and zirconium .
    Semixylenol orange
  • HY-D0836
    EDTA dipotassium dihydrate
    10+ Cited Publications

    Ethylenediaminetetraacetic acid dipotassium dihydrate

    DNA/RNA Synthesis Others
    EDTA dipotassium dihydrate is a metal ion chelator that forms stable and water-soluble chelates with a variety of metal ions. EDTA dipotassium is commonly used as a blood anticoagulant, which can effectively prevent blood coagulation and maintain the morphology and function of cells in blood samples. In the industrial field, EDTA dipotassium can be used to remove the adverse effects of metal ions and prevent oxidation and deterioration caused by metal ions .
    EDTA dipotassium dihydrate
  • HY-W129975

    Boron trioxide,99.98% trace metals basis

    Biochemical Assay Reagents
    Boric anhydride,99.98% trace metals basis (Boron trioxide,99.98% trace metals basis) is a kind of biochemical reagent.
    Boric anhydride,99.98% trace metals basis
  • HY-126823

    PGSK diacetate (5/6-mixture)

    Fluorescent Dye Others
    Phen green SK (PGSK) diacetate is a fluorescent heavy metal indicator that reacts with a variety of metal ions, including Fe2+, Cd2+, Co2+, Ni2+, Zn2+. PGSK diacetate displays excitation/emission maxima of 507/532 nm, respectively, and fluorescence is quenched upon interaction with metal ions
    Phen Green SK diacetate (5/6-mixture)
  • HY-Y0449C

    Ammonium rhodanide, 99.99% trace metals basis

    Biochemical Assay Reagents Others
    Ammonium thiocyanate, 99.99% trace metals basis is widely used in titration methods to determine the concentrations of various metal ions (especially iron and silver) by forming distinctly different complexes.
    Ammonium thiocyanate, 99.99% trace metals basis
  • HY-162760

    COMT Monoamine Oxidase Neurological Disease
    COMT-IN-1 (compound C12), a nitrophenolic analogue, is an orally active dopamine metabolic enzyme catechol-O-methyltransferase (COMT) inhibitor with IC50s of 0.37 μM, 95.58 μM and 58.82 μM for COMT, MAO-A and MAO-B, respectively. COMT-IN-1 exhibits chelation with a variety of metal ions. COMT-IN-1 exhibits good BBB permeability. COMT-IN-1 improves dopamine levels and ameliorates MPTP (HY-15608)-induced Parkinson's disease (PD) symptoms in mice .
    COMT-IN-1
  • HY-W088011B

    Sodium hydroxyacetate, 98%

    Biochemical Assay Reagents Others
    Sodium glycolate, 98% is a metal chelating agent.
    Sodium glycolate, 98%
  • HY-17624

    Neomycin B; Fradiomycin B

    Bacterial Antibiotic Infection
    Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent RNase P cleavage activity inhibitor with a Ki of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a Ki of 13.5 μM. Framycetin, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections .
    Framycetin

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