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IgE/Ag

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (5) Akt (1) Antibiotic (1) Antifolate (1) Apoptosis (14) Autophagy (1) Bacterial (6) Bcr-Abl (2) c-Kit (2) c-Met/HGFR (1) Cannabinoid Receptor (4) Casein Kinase (1) CDK (1) Cholecystokinin Receptor (1) COX (1) CRISPR/Cas9 (1) DAGL (3) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (1) Drug Metabolite (1) Dynamin (1) EGFR (23) Endogenous Metabolite (3) Enterovirus (2) ERK (1) FLT3 (1) Fluorescent Dye (6) Formyl Peptide Receptor (FPR) (1) GnRH Receptor (1) GPR35 (1) HCV (2) Hedgehog (1) HIV (6) HIV Integrase (1) HIV Protease (6) ICMT (1) IGF-1R (3) Influenza Virus (2) Insulin Receptor (1) Interleukin Related (8) Isocitrate Dehydrogenase (IDH) (6) Isotope-Labeled Compounds (7) JAK (2) MAGL (8) Methionine Adenosyltransferase (MAT) (1) MicroRNA (4) MMP (2) Necroptosis (1) NF-κB (2) Paraptosis (1) PARP (8) PDGFR (7) Phospholipase (3) Potassium Channel (3) Progesterone Receptor (1) Proton Pump (10) Pyruvate Kinase (2) Reverse Transcriptase (1) Smo (1) STAT (2) Syk (2) Thymidylate Synthase (2) TNF Receptor (5) Topoisomerase (3) Transthyretin (TTR) (2) Trk Receptor (1) TRP Channel (1) Tyrosinase (1) VEGFR (11) Virus Protease (3)
By Research Areas:	Cancer (92) Cardiovascular Disease (14) Endocrinology (6) Infection (15) Inflammation/Immunology (44) Metabolic Disease (25) Neurological Disease (10)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	miRNA mimics (1) miRNA agomirs (1) miRNA antagomirs (1) MicroRNAs (4) mRNA (5) miRNA inhibitors (1) Antisense Oligonucleotides (2)

166

Inhibitors & Agonists

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Biochemical Assay Reagents

Peptides

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Inhibitory Antibodies

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15844

AG-825 Tyrphostin Ag-825	EGFR Apoptosis	Neurological Disease Inflammation/Immunology Cancer
AG-825 (Tyrphostin AG-825) is a selective and ATP-competitive ErbB2 inhibitor which suppresses tyrosine phosphorylation, with an IC₅₀ of 0.35 μM. AG-825 displays anti-cancer activity . AG825 significantly accelerates apoptosis of human neutrophils . AG-825 is a potential agent for overcoming Mn-induced neurotoxicity or AD development .

HY-15492

AG-13958 1 Publications Verification Ag-013958	VEGFR	Cardiovascular Disease
AG-13958 (AG-013958), a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD) .

HY-101042

AG-494 Tyrphostin Ag 494	EGFR CDK	Cancer
AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC₅₀=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC₅₀s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis .

HY-10253

AG1024 5 Publications Verification Tyrphostin Ag 1024	IGF-1R Insulin Receptor Apoptosis	Endocrinology Cancer
AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC₅₀ of 7 μM. AG1024 inhibits phosphorylation of IR (IC₅₀=57 μM). AG1024 induces apoptosis and has anti-cancer activity .

HY-20878

Tyrphostin AG 879 1 Publications Verification Ag 879	Trk Receptor EGFR Apoptosis	Cancer
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation (IC₅₀ of 10 μM), but not TrKB and TrKC. Tyrphostin AG 879 is also a selective ErbB2 tyrosine kinase inhibitor with an IC₅₀ of 1 μM, and has at least 500-fold higher selectivity to ErbB2 than EGFR. Tyrphostin AG 879 has anticancer activity .

HY-13524

AG-1478 35+ Cited Publications Tyrphostin Ag-1478; NSC 693255	EGFR HCV Influenza Virus	Infection Cardiovascular Disease Metabolic Disease Cancer
AG-1478 (Tyrphostin AG-1478) is a selective EGFR tyrosine kinase inhibitor with IC₅₀ of 3 nM. AG-1478 has antiviral effects against HCV and encephalomyocarditis virus (EMCV).

HY-15336

AG 555 Tyrphostin Ag 555	EGFR Reverse Transcriptase	Cancer
AG 555 (Tyrphostin AG 555), a potent antiretroviral agent, is a potent and selective inhibitor of EGFR and blocks Cdk2 activation .

HY-118532

Tyrphostin AG30 Ag30	EGFR	Cancer
Tyrphostin AG30 (AG30) is a potent and selective EGFR tyrosine kinase inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts .

HY-101961

Tyrphostin AG 1288 Ag 1288	c-Kit	Inflammation/Immunology
Tyrphostin AG 1288 is a potent Tyrosine Kinase inhibitor. Tyrphostin AG 1288 inhibits ICAM1 expression and TNFα-mediated cytotoxicity in vitro .

HY-13524A

AG-1478 hydrochloride Tyrphostin Ag-1478 hydrochloride; NSC 693255 hydrochloride	EGFR HCV Influenza Virus	Infection Cardiovascular Disease Metabolic Disease Cancer
AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective EGFR tyrosine kinase inhibitor with IC₅₀ of 3 nM. AG-1478 hydrochloride has antiviral effects against HCV and encephalomyocarditis virus (EMCV) .

HY-137463

AG-636	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Cancer
AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ of 17 nM. AG-636 has strong anticancer effects .

HY-15491

AG-024322	COX Apoptosis	Cancer
AG-024322 is a potent ATP-competitive pan-CDK inhibitor against cell cycle kinases CDK1, CDK2, and CDK4 with K_i values in the 1-3 nM range . AG-024322 displays broad-spectrum anti-tumor activity and clear target modulation in vivo. AG-024322 induces cell apoptosis .

HY-107534

AG-045572	GnRH Receptor	Endocrinology
AG-045572 is a GnRH receptor antagonist with K_is of 6.0 nM and 3.8 nM for human and rat GnRH receptor, respectively. AG-045572 is metabolized by CYP3A and ressuppresses testosterone .

HY-155468

AG8.0	Others	Others
AG8.0 is a symmetric di-HSG bivalent hapten. AG8.0 is stable in vivo for 24 h .

HY-155447

AG3.0	Others	Cancer
AG3.0 is a symmetric di-HSG bivalent hapten. AG3.0 can be used for the research of pretargeted radioimmunotherapy .

HY-115625

AG-205	Progesterone Receptor	Cancer
AG-205 is a progesterone receptor membrane component-1 (PGRMC1) inhibitor with anti-mitotic, anti-migratory and anti-invasive activities. AG-205 increases expression of genes coding enzymes of the cholesterol biosynthetic pathway or of steroidogenesis. AG-205 promotes Apoptosis modified regulation of the cell cycle and reduces cell migration and invasion capacities in ovary and breast cancer cells .

HY-116111

AG 370	PDGFR	Cardiovascular Disease
AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC₅₀ of 20 μM). AG 370 displays weak inhibition of the EGF receptor .

HY-125314

AG-041R	Cholecystokinin Receptor	Endocrinology Cancer
AG-041R is a potent and selective CCK2 Receptor/Gastrin antagonist. AG-041R inhibits gastrin-evoked secretion of pancreastatin with an IC₅₀ of 2.2 nM. AG-041R inhibits cell growth of Mastomys ECL carcinoid tumor cells .

HY-101959

Tyrphostin AG213 Ag213	EGFR Topoisomerase	Cancer
Tyrphostin AG213 (AG213) is an inhibitor of epidermal growth factor receptor (EGFR) protein tyrosine kinase (IC₅₀=0.85 μM). Tyrphostin AG213 inhibits tyrosine kinase activity IC₅₀=2.4 μM) and topoisomerase II (IC₁₀₀=50 μM). Tyrphostin AG213 can induce nonapoptotic cell programmed death in tumor cells .

HY-143435

AG6033	Apoptosis	Cancer
AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect .

HY-19476

AG-7404	Virus Protease	Infection
AG-7404 is an inhibitor of picornaviral 3C protease, with anti-poliovirus activity (EC₅₀=0.080-0.674 μM). AG-7404 has synergy with V-073 (HY-104074) or BTA798 (HY-106254), and fully inhibits all V-073-resistant variants . AG-7404 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101957

AG 1295 3 Publications Verification	PDGFR	Cardiovascular Disease
AG 1295 is a selective platelet-derived growth factor receptor (PDGFR) tyrosine-kinase inhibitor. AG1295 abolishes autophosphorylation of the PDGFR whereas not affects the autophosphorylation of the EGF receptor .

HY-19640

AG-85	Others	Infection
AG-85 is a major secretion protein of Mycobacterium tuberculosis, and can be identified in ancient bone .

HY-117718

AG957 Tyrphostin Ag957; NSC 654705	Bcr-Abl	Cancer
AG957 (Tyrphostin AG957;NSC 654705) is a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity . AG957 is a bcr/abl kinase inhibitor with an IC₅₀ of 2.9 μM for p210 ^bcr/abl autokinase activity .

HY-116107

AG311	Necroptosis	Cancer
AG311 is an anticancer and antimetastatic agent. AG311 induces rapid necrosis in numerous cancer cell lines .

HY-100499

Tyrphostin AG 528 Tyrphostin B66; Ag 528	EGFR	Cancer
Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC₅₀s of 4.9 and 2.1 μM, respectively. Tyrphostin AG 528 (Tyrphostin B66) is a protein tyrosine kinase inhibitor, with IC₅₀s of 4.9 μM for epidermal growth factor receptors (EGFR) and 2.1 μM for ErbB2 . Tyrphostin AG 528 is also an anticancer agent .

HY-138630

AG-270 2 Publications Verification	Methionine Adenosyltransferase (MAT)	Cancer
AG-270 is an allosteric, noncompetitive, first-in-class, reversible and orally active MAT2A inhibitor, with an IC₅₀ of 14 nM .

HY-15287A

Nelfinavir Mesylate 10+ Cited Publications Ag 1343 Mesylate	HIV Protease HIV	Infection Cancer
Nelfinavir Mesylate (AG 1343 Mesylate) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir Mesylate (AG 1343 Mesylate) is a broad-spectrum, anticancer agent .

HY-119757A

Tyrphostin AG1433 hydrochloride SU1433 hydrochloride; Ag1433 hydrochloride	PDGFR	Inflammation/Immunology
Tyrphostin AG 1433 is a specific and potent inhibitor of PDGFR-β and of KDR/Flk-1. Tyrphostin AG 1433 acts as an angiogenesis inhibitor .

HY-108330

AG126 2 Publications Verification Tyrphostin Ag126	ERK	Inflammation/Immunology
AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research .

HY-112474

Tyrphostin AG 112	EGFR	Cancer
Tyrphostin AG 112 is an EGFR phosphorylation inhibitor .

HY-12000

AG490 Maximum Cited Publications 112 Publications Verification Tyrphostin Ag490; Tyrphostin B42	EGFR STAT JAK Autophagy	Cancer
AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

HY-13894

Tyrphostin AG1296 1 Publications Verification Ag1296	PDGFR c-Kit FLT3 Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC₅₀ of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC₅₀ in the micromolar range .

HY-18767

Ivosidenib 5+ Cited Publications Ag-120	Isocitrate Dehydrogenase (IDH)	Metabolic Disease Cancer
Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity .

HY-135680

I-OMe-Tyrphostin AG 538 I-OMe-Ag 538	IGF-1R	Metabolic Disease Cancer
I-OMe-Tyrphostin AG 538 (I-OMe-AG 538) is a specific inhibitor of IGF-1R (insulin-like growth factor-1 receptor tyrosine kinase). I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and is preferentially cytotoxic to nutrient-deprived PANC1 cells. I-OMe-Tyrphostin AG 538 is an ATP-competitive inhibitor of phosphatidylinositol-5-phosphate 4-kinase α (PI5P4Kα), with an IC₅₀ of 1 µM .

HY-119757

Tyrphostin AG1433 SU1433; Ag1433	PDGFR VEGFR	Cancer
Tyrphostin AG1433 (SU1433) is a tyrosine kinases inhibitor. AG1433 is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC₅₀s of 5.0 μM and 9.3 μM, respectively. Tyrphostin AG1433 prevents blood vessel formation .

HY-107459

(E/Z)-AG490 (E/Z)-Tyrphostin Ag490; (E/Z)-Tyrphostin B42	EGFR STAT JAK	Cancer
(E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.

HY-135436

AG 538	IGF-1R	Cancer
AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC₅₀ of 400 nM .

HY-108474

Nolatrexed dihydrochloride 1 Publications Verification Ag 337	Thymidylate Synthase	Cancer
Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a K_i of 11 nM for human thymidylate synthase . Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity .

HY-155444

AG5.0	Others	Cancer
AG5.0 is a bivalent hapten contains one HSG (histamine-succinyl-glycyl) group and one DTPA-indium group .

HY-D1392

Ag2Te QDs Ag2Te	Fluorescent Dye	Others
Ag2Te QDs (Ag2Te) is an effective biological probe in the second near-infrared window (NIR-II) that can be used in bioimaging with high tissue penetration depth and high spatiotemporal resolution .

HY-128113

AG-09/1	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
AG-09/1 is a specific formyl peptide receptor 1 (FPR1) agonist. N-formyl peptide receptors (FPR) are important in host defense .

HY-101041

(E)-AG 556 (E)-Tyrphostin Ag 556	EGFR	Inflammation/Immunology
(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production .

HY-18767A

(R,S)-Ivosidenib 1 Publications Verification (R,S)-Ag-120	Isocitrate Dehydrogenase (IDH)	Cancer
(R,S)-Ivosidenib ((R,S)-AG-120) is the less active enantiomer of Ivosidenib (AG-120) .

HY-D2191

Ag2S-COOH (1200 nm)	Fluorescent Dye	Others
Ag2S-COOH (1200 nm) is a fluorescent dyes.

HY-100962

(E)-AG 99 (E)-Tyrphostin 46; (E)-Tyrphostin Ag 99	EGFR	Cancer
(E)-AG 99 ((E)-Tyrphostin 46) is a potent EGFR inhibitor .

HY-13218

Acitazanolast WP-871	Others	Inflammation/Immunology
Acitazanolast is an orally active antiallergic agent, can inhibit histamine release. Acitazanolast can be used in study of type I anaphylaxis (immediate) caused by IgE antibodies .

HY-15287

Nelfinavir 10+ Cited Publications Ag1341	HIV Protease HIV	Infection Cancer
Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

HY-109165

Acoramidis Ag10	Transthyretin (TTR)	Metabolic Disease Endocrinology
Acoramidis (AG10) is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) is used in the study for transthyretin amyloidosis .

HY-109165A

Acoramidis hydrochloride Ag10 hydrochloride	Transthyretin (TTR)	Metabolic Disease Endocrinology
Acoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) hydrochloride is used in the study for transthyretin amyloidosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-P9950

Omalizumab 1 Publications Verification Olizumab; rhuMab-E25	Classification of Application Fields Disease Research Fields Cancer	Others
Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a K_D of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a K_D of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research .

HY-W013788

2-Palmitoylglycerol 2-Palm-Gl	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Cannabinoid Receptor
2-Palmitoylglycerol (2-Palm-Gl), an congener of 2-arachidonoylglycerol (2-AG), is a modest cannabinoid receptor CB1 agonist. 2-Palmitoylglycerol also may be an endogenous ligand for GPR119 .

HY-111326A

Naphazoline nitrate Naphthazoline nitrate	Classification of Application Fields Disease Research Fields Cancer	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR
Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline nitrate can be used for non-bacterial conjunctivitis research .

HY-125916

Pseurotin A	Alkaloids Structural Classification Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Disease Research Fields Cancer	Endogenous Metabolite
Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC₅₀=3.6 μM). Antitumor activity .

HY-117616

Laurotetanine (+)-Laurotetanine	Structural Classification Alkaloids Aporphine Alkaloids Classification of Application Fields Source classification Plants Lauraceae Isoquinoline Alkaloids Disease Research Fields Lindera aggregata (Sims) Kosterm. Cancer	NF-κB
Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots of Litsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition of IgE, histamine, and inflammatory reactions via down-regulating MUC5AC and NF-κB signaling pathways .

HY-N12823

Caprazene	Structural Classification Microorganisms Antibiotics Source classification	Bacterial
Caprazene is an antimycobacterial compound and precursor molecule for semi-synthetic antibacterial antibiotics, used for studies on tuberculosis and Mycobacterium avium complex infections, which can be isolated from the acid-treated caprazamycin (CPZ) A-G mixture .

HY-N12320

Majoranaquinone	Quinones Structural Classification Labiatae Source classification Plants Naphthalene Quinones Baccharis sarothroides A.Gray	Antibiotic
Majoranaquinone exhibits a high antibacterial effect against 4 Staphylococcus, 1 Moraxella, and 1 Enterococcus strains. Majoranaquinone shows substantial efflux pump inhibitory activity in Escherichia coliATCC 25922 strain. Majoranaquinone is found to be an effective biofilm formation inhibitor on E.coli, ATCC 25922 and E. coli K-12 AG100 bacteria .

Cat. No.	Product Name	Chemical Structure

HY-10065S1

Axitinib-d3
Axitinib-d₃ (AG-013736-d3) is deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively[1].

HY-13662BS

(R)-Lansoprazole-d4
(R)-Lansoprazole-d₄ is deuterium labeled (R)-Lansoprazole. (R)-Lansoprazole is the R enantiomer of Lansoprazole, Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[1][2].

HY-13662S

Lansoprazole-d4
Lansoprazole-d₄ is a deuterium labeled Lansoprazole. Lansoprazole is a proton pump inhibitor which prevents the stomach from producing acid[1].

HY-15209S

Repaglinide-d5
Repaglinide-d₅ is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for the treatment of type-2 diabetes mellitus[1].

HY-10065S

Axitinib-13C,d3
Axitinib- ¹³C,d₃ is a ¹³C-labeled and deuterium labeled Axitinib. Axitinib is a multi-targeted tyrosine kinase inhibitor with IC50s of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively.

HY-18690S

Enasidenib-d6
Enasidenib-d₆ (AG-221-d₆)is the deuterium labeledEnasidenib(HY-18690) . Enasidenib is an oral, potent, reversible, selective inhibitor of the IDH2 mutant enzymes, with IC₅₀s of 100 and 400 nM against IDH2 ^R140Q and IDH2 ^R172K, respectively .

HY-W008614S

Lansoprazole sulfone-d4

Lansoprazole sulfone-d₄ (AG-1813-d₄) is the deuterium labeled Lansoprazole sulfone. Lansoprazole sulfone-d₄ is an orally active and selective inhibitor of H ⁺, K ⁺-ATPase. Lansoprazole sulfone-d₄ can significantly stimulates gastric acid secretion by inhibiting H ⁺, K ⁺-ATPase. Lansoprazole sulfone-d₄ has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease .

HY-106161S1

Rupintrivir-d7
Rupintrivir-d7 is a deuterated labeled Rupintrivir . Rupintrivirvr (AG7088), an antiviral agent, is a potent, selective and irreversible inhibitor of human rhinovirus (HRV) 3C protease. Rupintrivirvr inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays, with a mean EC₅₀ of 0.023 μM. Rupintrivirvr shows immune-modulatory effect .

HY-15287S

Nelfinavir-d3
Nelfinavir-d₃ (AG1341-d3) is the deuterium labeled Nelfinavir. Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (Ki=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent[1][2][3].

HY-15287S1

Nelfinavir-d4
Nelfinavir-d₄ is deuterated labeled Nelfinavir (HY-15287). Nelfinavir (AG-1341) is a potent and orally bioavailable HIV-1 protease inhibitor (K_i=2 nM) for HIV infection. Nelfinavir is a broad-spectrum, anticancer agent .

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