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region

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Amyloid-β (4) Androgen Receptor (1) Antibiotic (4) Apoptosis (9) Atg8/LC3 (1) Aurora Kinase (2) Autophagy (5) Bacterial (2) Bcl-2 Family (2) Bcr-Abl (1) Biochemical Assay Reagents (9) c-Met/HGFR (1) CD3 (1) CD47 (1) Checkpoint Kinase (Chk) (1) CRM1 (2) Deubiquitinase (1) DGK (2) DNA Stain (1) DNA/RNA Synthesis (1) E1/E2/E3 Enzyme (1) EGFR (3) Endogenous Metabolite (7) Enterovirus (1) Epigenetic Reader Domain (3) Estrogen Receptor/ERR (1) Filovirus (1) Fluorescent Dye (16) Fungal (2) G Protein-coupled Receptor Kinase (GRK) (1) HBV (4) HCV (3) Histone Acetyltransferase (1) Histone Methyltransferase (2) HIV (11) HSP (1) HSV (2) iGluR (3) Influenza Virus (2) Integrin (2) Interleukin Related (2) Isotope-Labeled Compounds (4) Keap1-Nrf2 (1) Liposome (1) LXR (1) MEK (1) Mitochondrial Metabolism (1) Mitophagy (1) Mps1 (1) Mucin (1) nAChR (3) Neuropeptide Y Receptor (2) Notch (3) PACAP Receptor (1) PCSK9 (1) PD-1/PD-L1 (1) Phosphatase (1) Pim (1) PIN1 (1) PKC (1) Polo-like Kinase (PLK) (1) PPAR (1) PROTACs (1) Ras (1) Reactive Oxygen Species (1) Renin (1) Reverse Transcriptase (3) SARS-CoV (1) Sirtuin (1) STAT (2) TNF Receptor (2) Toll-like Receptor (TLR) (2) TRP Channel (1) VEGFR (2) Wnt (1) α-synuclein (2)
By Research Areas:	Cancer (48) Cardiovascular Disease (9) Endocrinology (3) Infection (29) Inflammation/Immunology (26) Metabolic Disease (8) Neurological Disease (21)
Oligonucleotides:	Pegylated Lipids (1) Nucleoside Phosphoramidites (1) Antisense Oligonucleotides (4)

143

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D2195

AgAuSe-PEG-NH2 (1000 nm)	Fluorescent Dye	Others
AgAuSe-PEG-NH2 (1000 nm) is a fluorescent quantum dot that emits fluorescence in the near-infrared II region, with an emission peak reaching 1000 nm that can be used in bioimaging.

HY-110374

NVS-CECR2-1	Epigenetic Reader Domain Apoptosis	Cancer
NVS-CECR2-1, a non-BET family Bromodomain (BRD) inhibitor, is a potent and selective cat eye syndrome chromosome region, candidate 2 (CECR2) inhibitor. NVS-CECR2-1 binds to CECR2 BRD with high affinity (IC₅₀=47 nM; K_D=80 nM). NVS-CECR2-1 exhibits cytotoxic activity and induces apoptosis against various cancer cells by targeting CECR2 as well as via CECR2-independent mechanism .

HY-P1572

*Handle region* peptide, rat**	Renin	Inflammation/Immunology
Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye.

HY-P4043

*Hepatitis b virus pre-s region* (120-145)**	HBV	Infection Inflammation/Immunology
Hepatitis b virus pre-s region (120-145) is a preS2 peptide that inhibits the binding of single-chain Fv fragment (scFv) or IgG to r-HBsAg .

HY-133852

FD-1080	Fluorescent Dye	Others
FD-1080 is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 can be used for in vivo imaging .

HY-133852A

FD-1080 free acid	Fluorescent Dye	Others
FD-1080 free acid is a fluorophore with both excitation and emission in the NIR-II region (Ex=1064 nm, Em=1080 nm). FD-1080 free acid can be used for in vivo imaging .

HY-D1065

NIR-H2O2	Fluorescent Dye	Inflammation/Immunology
NIR-H2O2 is a cell-permeable near-infrared (NIR) fluorescent turn-on sensor. NIR-H2O2 has both absorption and emission in the NIR region. NIR-H2O2 responds to H₂O₂ with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-H2O2 is capable of imaging endogenously produced H₂O₂ in living cells and mice .

HY-P5309

*(Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region* Peptide**	Biochemical Assay Reagents	Inflammation/Immunology
(Thr(GalNAc)4,7,15,Ser(GalNAc)9,11)-IgA1 Hinge Region Peptide is a synthetic glycopeptide and can be used for detection of gender difference and epitope specificity of IgG antibody activity against IgA1 hinge portion in IgA nephropathy patients .

HY-P5310

VPSTPPTPSPSTPPTPSPS	Biochemical Assay Reagents	Others
VPSTPPTPSPSTPPTPSPS is an IgA1 hinge region peptide .

HY-D1066

NIR-Thiol dinitrobenzenesulfonate	Fluorescent Dye	Others
NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. NIR-Thiol dinitrobenzenesulfonate responds to thiol with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-Thiol dinitrobenzenesulfonate is capable of imaging endogenously produced thiol in living cells and mice .

HY-P1511

PACAP-Related Peptide (PRP), human	PACAP Receptor	Neurological Disease
PACAP-Related Peptide (PRP), human is a 29 amino-acid region of the PACAP precursor protein.

HY-NP006

Protein A SPA	Endogenous Metabolite	Inflammation/Immunology
Protein A (SPA) is an immunoglobulin (Ig) binding protein that exists on the surface of bacteria and can be freely secreted into the extracellular environment. Protein A blocks opsonization and phagocytosis and induces B-cell death in vitro by binding to the Fc region of antibodies and the Fab region of B-cell receptors. Protein A has the ability to inhibit opsonization and phagocytosis in vitro .

HY-120318

Zeaxanthin	Endogenous Metabolite	Inflammation/Immunology Cancer
Zeaxanthin, a diet-obtained carotenoid, presents in the macula region of the eye. Zeaxanthin shows antioxidant effects .

HY-P990110

Lecanemab (Mouse IGG2a) Mab158	Amyloid-β	Neurological Disease
Lecanemab (Mouse IGG2a) is a monoclonal antibody that targets soluble β-amyloid and has the potential to reduce cognitive decline. The variable region of Lecanemab (Mouse IGG2a) is consistent with that of Lecanemab, while the constant region is of Mouse IGG2a sequence. Lecanemab (Mouse IGG2a) holds promise for research in the field of Alzheimer's disease .

HY-P3522

REDV	Integrin	Cancer
REDV is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. REDV can mediate adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1(α4β1). REDV can be used for the research of cell adhesion .

HY-P9954

Catumaxomab	CD3	Cancer
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers .

HY-147817

Heme Oxygenase-2-IN-1	Reactive Oxygen Species	Inflammation/Immunology Cancer
Heme Oxygenase-2-IN-1 (Compound 9) is a potent, selective heme oxygenase-2 (HO-2) inhibitor with IC₅₀ values of 0.9 μM and 14.9 μM against HO-2 and HO-1, respectively .

HY-P3522A

REDV TFA	Integrin	Cancer
REDV TFA is the minimal active sequence within the CS5 site of the alternatively spliced type III connecting segment (IIICS) region of fibronectin. REDV TFA can mediate adhesion to the IIICS region of plasma fibronectin by binding the integrin alpha 4 beta 1(α4β1). REDV TFA can be used for the research of cell adhesion .

HY-P990040

Exlinkibart LVGN-6051	TNF Receptor	Cancer
Exlinkibart (LVGN-6051) targets TNFRSF9 and is an IgG1κ antibody humanized through complementarity-determining region (CDR) grafting technology.

HY-P990748

Lunsekimig	Interleukin Related	Inflammation/Immunology
Lunsekimig is an anti-TSLP/IL13/ALB monoclonal antibody composed of 5 sequentially linked variable region heavy chains .

HY-163513

AACA	Wnt	Endocrinology
AACA is an inhibitor for sclerostin, that binds sclerostin on loop3 region with K_d of 15.4 nM. AACA exhibits anti-osteoporosis activity through Wnt signaling pathway .

HY-P4808

PHF6	Amyloid-β Autophagy	Neurological Disease
PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .

HY-147179

INX-SM-56	ADC Cytotoxin	Inflammation/Immunology
INX-SM-56 is a cytotoxin that can be used for the synthesis of anti-VISTA antibody agent conjugate. VISTA: V-region Immunoglobulin-containing Suppressor of T cell Activation .

HY-D2198

AgAuSe-PEG-NH2 (1120 nm)	Fluorescent Dye	Others
AgAuSe-PEG-NH2 (1120 nm) is a fluorescent quantum dot that emits fluorescence in the near-infrared II region, with an emission peak reaching 1120 nm that can be used in bioimaging .

HY-139351

Gibberellins A4/A7 GA4+7	Others	Others
Gibberellins A4/A7 induces stimulation of tracheid production in the terminal shoot of intact plants is mediated through an increase in the IAA level in the cambial region .

HY-P0272

Peptide T	HIV	Infection
Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.

HY-D1474

3,3'-Bis(3-sulfopropyl)-5,5'-diphenyl-9-ethyloxacarbocyanine betaine sodium	Biochemical Assay Reagents	Others
3,3'-Bis(3-sulfopropyl)-5,5'-diphenyl-9-ethyloxacarbocyanine betaine sodium is a photographic sensitizer in the green spectral region .

HY-P4318

HHV-2 Envelope Glycoprotein G (552-574)	HSV	Infection
HHV-2 Envelope Glycoprotein G (552-574) is an immunodominant region of glycoprotein G (gG-2) reactive with all herpes simplex (HSV-2) sera .

HY-120318R

Zeaxanthin (Standard)	Endogenous Metabolite	Inflammation/Immunology Cancer
Zeaxanthin (Standard) is the analytical standard of Zeaxanthin. This product is intended for research and analytical applications. Zeaxanthin, a diet-obtained carotenoid, presents in the macula region of the eye. Zeaxanthin shows antioxidant effects .

HY-P0272A

Peptide T TFA	HIV	Infection
Peptide T (TFA) is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.

HY-117996

KPT-251	CRM1 Apoptosis	Cancer
KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity .

HY-113761

ASN03576800	Filovirus	Infection
ASN03576800 could be a potent inhibitor for Ebola virus matrix protein VP40 in process of viral assembly and budding process. ASN03576800 occupies the RNA binding region of VP40 .

HY-149835

TTX-P	Fluorescent Dye	Others
TTX-P is a fluorescent probe. TTX-P responds in situ to the overexpressed alkaline phosphatase (ALP) in liver, imaging of diabetic liver injury in the near-infrared second-window (NIR-II) region .

HY-100589

Isepamicin sulfate Sch 21420 sulfate	Bacterial Antibiotic	Infection
Isepamicin sulfate (Sch 21420 sulfate) is a broad spectrum aminoglycoside antibiotic. Isepamicin sulfate exhibits considerable antimicrobial activity against Gram-negative non-fermenters in a region with high antimicrobial resistance .

HY-107683

LY-2087101	nAChR	Neurological Disease
LY-2087101 is an allosteric potentiator of α7 nAChRs. LY-2087101 causes potentiation of agonist-evoked α7 responses by binding within the nAChR transmembrane region .

HY-P4808A

PHF6 TFA	Amyloid-β Autophagy	Neurological Disease
PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein .

HY-153837

ISIS 14803	HCV	Infection
ISIS 14803 is a 20-unit antisense phosphorothioate oligodeoxynucleotide that binds to hepatitis C virus (HCV) RNA at the translation initiation region of the internal ribosome entry site (IRES) and inhibits protein expression in cell culture.

HY-153837A

ISIS 14803 sodium	HCV	Infection
ISIS 14803 sodium is a 20-unit antisense phosphorothioate oligodeoxynucleotide that binds to hepatitis C virus (HCV) RNA at the translation initiation region of the internal ribosome entry site (IRES) and inhibits protein expression in cell culture.

HY-14835

Burapitant SSR240600	Others	Others
Burapitant (SSR240600) is a compound that modulates cholinergic transmission and regulates acetylcholine release in the limbic/prefrontal region of the rat striatum, with its effects being influenced by the interaction of 5-HT? and 5-HT? receptors.

HY-D1067

NIR dye-1	Fluorescent Dye	Others
NIR dye-1 (Compound 1h) is a near-infrared (NIR) fluorescent dye. NIR dye-1 has absorption and emission in the NIR region, while retaining an optically tunable hydroxyl group .

HY-153494

Rosomidnar PNT100	Bcl-2 Family	Cancer
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

HY-153494A

Rosomidnar sodium PNT100 sodium	Bcl-2 Family	Cancer
PNT100 sodium is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

HY-108605

PIM1-IN-2	Pim	Cancer
PIM1-IN-2 is a potent and ATP competitive Pim-1 inhibitor with a K_i of 91 nM. PIM1-IN-2 targets the ATP-binding kinase hinge region not by forming classical hydrogen bonds .

HY-144308

RMS-07	Mps1	Others
RMS-07 is a covalent Monopolar Spindle Kinase 1 (MPS1/TTK) inhibitor, with an apparent IC₅₀ of 13.1 nM. RMS-07 targets a poorly conserved cysteine in the kinase's hinge region .

HY-121638A

(5Z,2E)-CU-3 1 Publications Verification	Apoptosis DGK	Cancer
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC₅₀ value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a K_m value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells .

HY-120088

PF-06446846	PCSK9	Cardiovascular Disease
PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 directly and selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region .

HY-154979

Anti-hepatic fibrosis agent 2	Others	Inflammation/Immunology
Anti-hepatic fibrosis agent 2 (Compound 6k) is an orally active COL1A1 inhibitor. Anti-hepatic fibrosis agent 2 is an anti-fibrogenic agent targeting ewing sarcoma breakpoint region 1 (EWSR1) .

HY-121546

ALLO-1	Atg8/LC3 Autophagy	Cancer
ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif .

HY-N10472

STAT3-IN-14	STAT	Cancer
STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3 .

HY-P3892

Protein Kinase C (19-35) Peptide	PKC	Inflammation/Immunology
Protein Kinase C (19-35) Peptide is the PKC pseudosubstrate inhibitor/region. Protein Kinase C (19-35) Peptide possibly blocks the substrate-binding site in its kinase domain, makes the cytoplasmic form of PKC inactive .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-120318

Zeaxanthin	Structural Classification Classification of Application Fields Source classification Erythrina melanacantha Taub. ex Harms Whitening Agent Endocrine diseases Plants Compositae Endogenous metabolite Food Research Other Terpenoids Immune System Disorder Microorganisms Terpenoids Disease markers Pigments Cosmetic Research Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Zeaxanthin, a diet-obtained carotenoid, presents in the macula region of the eye. Zeaxanthin shows antioxidant effects .

HY-113294

3-Hydroxykynurenine 3-Hydroxy-DL-kynurenine	Structural Classification Monophenols Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite Apoptosis
3-Hydroxykynurenine, a?metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis .

HY-N2673

5-Heptadecylresorcinol 5-n-Heptadecylresorcinol; AR-C17	Structural Classification Gramineae Source classification Secale cereale Phenols Polyphenols Plants	Sirtuin
5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity .

HY-120318R

Zeaxanthin (Standard)	Other Terpenoids Structural Classification Immune System Disorder Microorganisms Terpenoids Source classification Erythrina melanacantha Taub. ex Harms Disease markers Endocrine diseases Plants Compositae Endogenous metabolite	Endogenous Metabolite
Zeaxanthin (Standard) is the analytical standard of Zeaxanthin. This product is intended for research and analytical applications. Zeaxanthin, a diet-obtained carotenoid, presents in the macula region of the eye. Zeaxanthin shows antioxidant effects .

HY-N10472

STAT3-IN-14	Nicotiana tabacum L. Source classification Plants Solanaceae Naphthalene Quinones	STAT
STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3 .

HY-N12613

Sydowimide A	Structural Classification Natural Products Microorganisms Marine natural products Source classification Marine microorganism	Phosphatase
Sydowimide A is a potent inhibitor of Src homology region 2 domain-containing phosphatase-1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP) and leukocyte common antigen (CD45), with IC₅₀ values of 1.5, 2.4 and 18.83 μM, respectively .

HY-106784A

(E)-Ajoene	Structural Classification Natural Products Source classification Allium sativum L. Plants Amaryllidaceae	Others
(E)-Ajoene is a oxygenated ajoene and organosulfur compound, which can be acquired via allicin decomposing. The polysulfides from garlic can be converted by human red blood cells into hydrogen sulfide (H2S) and allyl glutathione. (E)-Ajoene has been proved to show neuroprotective effects against ischemic damage. (E)-Ajoene is orally active to inhibit lipid peroxidation. (E)-Ajoene increases the number of cresyl violet-positive neurons and decreases the number of reactive gliosis in the CA1 region .

Cat. No.	Product Name	Chemical Structure

HY-B0250S1

Lamivudine-13C,15N2,d2
Lamivudine-13C,15N2,d2 (BCH-189-13C,15N2,d2) is a 13C, 15N, and deuterium labeled Lamivudine (HY-B0250). Lamivudine is an orally active and blood-brain barrier permeable nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus (HBV) reverse transcriptase .

HY-B0250S

Lamivudine-15N,d2
Lamivudine- ¹⁵N,d₂ is ¹⁵N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-P5201S

VTSEGAGLQLQK-13C6,15N2
VTSEGAGLQLQK- ¹³C₆, ¹⁵N₂ is the ¹³C and ¹⁵N labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA). VTSEGAGLQLQK can be used to bind anti-drug antibodies (ADA) in plasma and quantitatively analyze the therapeutic effect .

HY-P5201S1

VTSEGAGLQLQK-13C6,15N2 TFA
VTSEGAGLQLQK- ¹³C₆, ¹⁵N₂ (TFA) is the ¹³C- and ¹⁵N-labeled VTSEGAGLQLQK. VTSEGAGLQLQK is an amino acid sequence in the C-terminal region of recombinant human alpha-acid glucosidase (rhGAA), which can be used to bind anti-drug antibodies in plasma and quantitatively analyze the therapeutic effect .

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Species:	Human (32) Virus (1) Rhesus Macaque (4) Mouse (15) Rat (4) Cynomolgus (6) Rabbit (1)
Tag:	His (43) Tag Free (15) Avi (17) GST (2) Fc (1) Flag (1)
Source:	HEK293 (52) CHO (3) Sf9 insect cells (4) E. coli (4)


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region

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products