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Results for "

sensitivity

" in MedChemExpress (MCE) Product Catalog:

356

Inhibitors & Agonists

4

Screening Libraries

49

Fluorescent Dye

110

Biochemical Assay Reagents

16

Peptides

4

MCE Kits

2

Inhibitory Antibodies

28

Natural
Products

6

Isotope-Labeled Compounds

2

Click Chemistry

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D1040
    Cy5.5-COOH

    Cyanine 5.5 carboxylic acid

    		 Fluorescent Dye Others
    CY5.5-COOH (Cyanine 5.5 carboxylic acid) is a fluorescent dye, is commonly used in bioimaging. CY5.5-COOH shows narrow absorption spectrum, and high sensitivity and stability .
    Cy5.5-COOH
  • HY-W440988
    DOPE-mPEG, MW 2000

    		Liposome Others
    DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner .
    DOPE-mPEG, MW 2000
  • HY-77813
    Benzyl isothiocyanate

    		Bacterial Apoptosis Antibiotic Parasite Autophagy Reactive Oxygen Species Infection Endocrinology Cancer
    Benzyl isothiocyanate is an orally available isothiocyanate with bactericidal, anticancer, antiangiogenic and anthelmintic activities. Benzyl isothiocyanate exerts anticancer functions by regulating multiple signaling pathways, including apoptosis, cell proliferation, cell cycle arrest, metastasis, angiogenesis, and autophagy. In addition, Benzyl isothiocyanate can enhance muscle insulin sensitivity to improve obesity-induced hyperglycemia .
    Benzyl isothiocyanate
  • HY-W013435
    1,2-Diaminoanthraquinone

    		Fluorescent Dye Others
    1,2-Diaminoanthraquinone is a sensitivity, specificity and nontoxic nitric oxide (NO) fluorescent probe. 1,2-Diaminoanthraquinone can be used to detect NO productions in live cell and animals with a maximum of absorption at about 540 nm and a detection limit of 5 μM for NO .
    1,2-Diaminoanthraquinone
  • HY-D1506
    Fl-DIBO

    		Fluorescent Dye Others
    Fl-DIBO (fluorogenic dibenzocyclooctyne) is a selective and high sensitivity fluorescent probe to azide compounds. Fl-DIBO can react rapidly with azide compounds to form new highly fluorescent products with a maximum emission wavelength of 469 nm and excitation wavelength of 363 nm. Fl-DIBO can be used to label diazo-tagged proteins without detectable background signal interference . Fl-DIBO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Fl-DIBO
  • HY-D1456
    TEPC466

    		Pyruvate Kinase Cancer
    TEPC466 is a novel TEPP-46-based aggregation-induced emission (AIE) probe. TEPC466 shows a high degree of selectivity and sensitivity for the detection of PKM2 protein via the AIE effect. EPC466 can be used for the detection of PKM2. TEPC466 is successfully applied in imaging the PKM2 protein in colorectal cancer cells with low toxicity. TEPC466 is a useful tool for cancer diagnosis and research .
    TEPC466
  • HY-D1040A
    CY5.5-COOH chloride

    Cyanine 5.5 carboxylic acid chloride

    		 Fluorescent Dye Others
    CY5.5-COOH (Cyanine 5.5 carboxylic acid) chloride is a fluorescent dye, is commonly used in bioimaging. CY5.5-COOH chloride shows narrow absorption spectrum, and high sensitivity and stability .
    CY5.5-COOH chloride
  • HY-163294
    PPARγ agonist 10

    		PPAR Metabolic Disease
    PPARγ agonist 10 (compound 33g) is a PPARγ agonist, and stimulats the insulin secretion, glucose uptake and insulin Sensitivity in βTC6 Cells .
    PPARγ agonist 10
  • HY-14771
    Imeglimin

    EMD 387008

    		 Mitochondrial Metabolism Reactive Oxygen Species Metabolic Disease
    Imeglimin (EMD 387008) is an oral glucose-lowering agent. Imeglimin improves insulin sensitivity. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function .
    Imeglimin
  • HY-N6181
    Terrelumamide A

    		Others Endocrinology
    Terrelumamide A is a lumazine-containing peptide. Terrelumamide A is isolated from the culture broth of the marine-derived fungus Aspergillus terreus. Terrelumamide A exhibits pharmacological activity by improving insulin sensitivity. Terrelumamide A has the potential in the application of DNA sequence recognition .
    Terrelumamide A
  • HY-B0627
    Metformin
    Maximum Cited Publications
    132 Publications Verification

    1,1-Dimethylbiguanide

    		 AMPK Autophagy Mitophagy Apoptosis mTOR Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
    Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
    Metformin
  • HY-17471A
    Metformin hydrochloride
    Maximum Cited Publications
    132 Publications Verification

    1,1-Dimethylbiguanide hydrochloride

    		 AMPK Autophagy Mitophagy Apoptosis mTOR Cardiovascular Disease Metabolic Disease Cancer
    Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
    Metformin hydrochloride
  • HY-B0627A
    Metformin (glycinate)

    1,1-Dimethylbiguanide (glycinate)

    		 AMPK Autophagy Mitophagy Apoptosis mTOR Cardiovascular Disease Metabolic Disease Cancer
    Metformin (1,1-Dimethylbiguanide) glycinate inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin glycinate also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin glycinate regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .
    Metformin (glycinate)
  • HY-P10746
    EB1002

    		Neurokinin Receptor Metabolic Disease
    EB1002 is a selective NK2R agonist. EB1002 significantly raises the expression levels of mitochondrial biosynthesis-related genes (like PGC-1α) in obese mice, indicating that it promotes energy expenditure by boosting mitochondrial activity. EB1002 also increases the insulin sensitivity and improves glycolipid metabolism of the mice. EB1002 is promising for research of obesity and type 2 diabetes .
    EB1002
  • HY-129283
    Goralatide

    		Ras Others
    Goralatide is a compound that regulates the thermal sensitivity of hematopoietic progenitor cells. It can reduce the thermal sensitivity of normal hematopoietic progenitor cells and increase the difference in thermal sensitivity between leukemia progenitor cells and normal progenitor cells, thereby increasing the inhibition window of hyperthermia therapy.
    Goralatide
  • HY-101075
    L-690330

    		Phosphatase Others
    L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 exhibits 10-fold more sensitive than mouse and rat IMPase .
    L-690330
  • HY-101075A
    L-690330 hydrate

    		Phosphatase Others
    L-690330 hydrate is a competitive inhibitor of inositol monophosphatase (IMPase) with Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively. L-690330 hydrate exhibits 10-fold more sensitive than mouse and rat IMPase .
    L-690330 hydrate
  • HY-125337
    SC4453

    		Na+/K+ ATPase Cardiovascular Disease
    SC4453 is a digoxin analogue in which the lactone ring at C17β is replaced by a pyrazine ring. SC4453 is slightly inferior to digoxin in inhibiting (Na+ + K+)-ATPase, but shows similar sensitivity to potassium ions. The differences in the sensitivity of SC4453 to heart and brain tissue from different species are mainly due to differences in its dissociation rate from the receptor. These observations confirm the high sensitivity of the human heart to cardiac glycosides.
    SC4453
  • HY-100718
    SCH00013

    		Calcium Channel Cardiovascular Disease
    SCH00013 is a cardiotonic that primarily increases the sensitivity of muscle fibers to Ca++.
    SCH00013
  • HY-101937A
    (±)-ANAP

    		Fluorescent Dye Others
    (±)-ANAP is the unnatural amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity.
    (±)-ANAP
  • HY-101937C
    (±)-ANAP hydrochloride
    1 Publications Verification

    		 Fluorescent Dye Others
    (±)-ANAP hydrochloride is the unnatural amino acid analog of prodan, acts as a fluorescent probes, and enhances environmental sensitivity.
    (±)-ANAP hydrochloride
  • HY-P0222
    PKI(5-24)
    3 Publications Verification

    		 PKA Others
    PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .
    PKI(5-24)
  • HY-P0222A
    PKI(5-24) TFA

    		PKA Others
    PKI(5-24) TFA is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) TFA corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor .
    PKI(5-24) TFA
  • HY-77813R
    Benzyl isothiocyanate (Standard)

    		Bacterial Apoptosis Antibiotic Parasite Autophagy Reactive Oxygen Species Infection Endocrinology Cancer
    Benzyl isothiocyanate (Standard)
  • HY-121796
    Mixanpril

    		Neprilysin Others
    Mixanpril is a compound with the ability to modulate insulin sensitivity and has the activity of regulating insulin sensitivity and femoral blood flow in obese Zucker rats. Mixanpril can affect insulin-mediated glucose disposal in obese Zucker rats and also has a regulatory effect on femoral blood flow, with different effects compared to the ACE inhibitor captopril.
    Mixanpril
  • HY-137851
    S-Pyruvylglutathione

    		Drug Metabolite Others
    S-Pyruvylglutathione is a serum metabolite and can be used as a potential marker for sensitivity of gastric cancer to neoadjuvant chemotherapy .
    S-Pyruvylglutathione
  • HY-W087907
    Acetylsalicylsalicylic acid

    		Drug Intermediate Inflammation/Immunology
    Acetylsalicylsalicylic acid exhibits immunogenicity that induces contact sensitivity and causes skin erythema and slight edema in guinea pigs .
    Acetylsalicylsalicylic acid
  • HY-109545
    Isopropyl unoprostone

    Unoprostone isopropyl ester; UF-021

    		 Potassium Channel Others
    Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca 2+-activated K + (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity .
    Isopropyl unoprostone
  • HY-164368
    GLUT4 activator 2

    		Phosphodiesterase (PDE) Insulin Receptor Metabolic Disease
    GLUT4 activator 2 (C59) is an insulin sensitizer, which can be used for research of diabetic diseases. GLUT4 activator 2 improves glucose uptake and insulin sensitivity in rodents. GLUT4 activator 2 interacts with Unc119 and Unc119B resulting in increased insulin sensitivity and GLUT4 translocation .
    GLUT4 activator 2
  • HY-19003
    Isomazole

    323MHb; Isosulmazole

    		 Phosphodiesterase (PDE) Cardiovascular Disease
    Isomazole is a new cardiotonic agent. Isomazole increases the calcium sensitivity in atrial fibers and has a direct effect on contractile proteins .
    Isomazole
  • HY-D1422
    ER Thermo Yellow

    BDNCA-346

    		 Fluorescent Dye
    ER Thermo Yellow is an endoplasmic reticulum-targeted temperature-visible fluorescent probe with high sensitivity (3.9%/°C).
    ER Thermo Yellow
  • HY-170462
    CSPD substrate

    		Biochemical Assay Reagents Others
    CSPD substrate is a chemiluminescent substrate of alkaline phosphatase. CSPD substrate provides the enhanced alkaline phosphatase sensitivity and a more simplified assay .
    CSPD substrate
  • HY-161004
    AMOZ-CH-acid

    		Biochemical Assay Reagents Inflammation/Immunology
    AMOZ-CH-acid (Hapten 5) is an immunizing and heterologous hapten. AMOZ-CH-acid and ovalbumin conjugate is a coating antigen that improves assay sensitivity .
    AMOZ-CH-acid
  • HY-W004206
    2-(4-Methoxyphenyl)acetic acid

    4-Methoxyphenylacetic acid

    		 Endogenous Metabolite Cancer
    2-(4-Methoxyphenyl)acetic acid is a plasma metabolite, with high sensitivity and specificity value as a biomarker for discriminating between NSCLC and healthy controls.
    2-(4-Methoxyphenyl)acetic acid
  • HY-W141876
    DL-2-Aminopimelic Acid

    		Bacterial Others
    DL-2-Aminopimelic Acid is a weak agonist of glutamate receptors and also reduces the sensitivity of leech glutamate receptors to glutamate .
    DL-2-Aminopimelic Acid
  • HY-D1258
    AC-green

    VDP-green

    		 Fluorescent Dye Others
    AC-green (VDP-green) is a β-allyl carbamate fluorescent probe for specifically imaging vicinal dithiol proteins (VDPs) in living systems (λex/λem=400/475 nm). AC-green can detect the reduced bovine serum albumin (rBSA) with high sensitivity. AC-green displays low toxicity and features high sensitivity, and is suitable for sensing VDPs in living cells and zebrafishes .
    AC-green
  • HY-150218
    Agatolimod sodium

    ODN 2006 sodium; ODN 7909 sodium; PF-3512676 sodium; CpG 7909 sodium

    		 Toll-like Receptor (TLR) Cancer
    Agatolimod sodium (ODN 2006) is a class B CpG ODN and is a TLR9 agonist. Agatolimod sodium can be used as vaccine adjuvant. Agatolimod sodium can be used for the research of cancer. Sequence: 5’-TCGTCGTTTTGTCGTTTTGTCGTT-3’ .
    Agatolimod sodium
  • HY-131485A
    3-Acetylpyridine adenine dinucleotide, 95%

    3-APAD, 95%; 3-Acetylpyridine NAD, 95%

    		 Lactate Dehydrogenase Metabolic Disease
    3-Acetylpyridine adenine dinucleotide, 95% (3-APAD, 95%)is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 95% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite .
    3-Acetylpyridine adenine dinucleotide, 95%
  • HY-162324
    MX106-4C

    		Survivin Cancer
    MX106-4C is a survivin inhibitor that selectively kills ABCB1-positive colorectal cancer cells. MX106-4C can exert synergistic anticancer effects with Doxorubicin or resensitize drug-resistant ABCB1 cells to Doxorubicin .
    MX106-4C
  • HY-12402
    SBC-115076
    1 Publications Verification

    		 PCSK9 Cardiovascular Disease
    SBC-115076 is a potent proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism .
    SBC-115076
  • HY-19003A
    Isomazole hydrochloride

    323MHb hydrochloride; Isosulmazole hydrochloride

    		 Phosphodiesterase (PDE) Cardiovascular Disease
    Isomazole (323MHb) hydrochloride is a cardiotonic agent. Isomazole hydrochloridei increases the calcium sensitivity in atrial fibers and has a direct effect on contractile proteins .
    Isomazole hydrochloride
  • HY-D0868
    Bicine

    		Biochemical Assay Reagents Others
    Bicine is a buffer used in physiological research. Bicine is a derivative of the simple amino acid glycine that increases the sensitivity of guanosine enzyme histochemical detection .
    Bicine
  • HY-16459
    Glycididazole sodium

    Sodium glycididazole

    		 Apoptosis Cancer
    Glycididazole sodium (Sodium glycididazole) is a radiosensitizer. Glycididazole sodium increases the sensitivity of nasopharyngeal carcinoma cells to radiation, through increaased DNA damage and enhanced apoptosis in NPC cells
    Glycididazole sodium
  • HY-W099735
    Bis(2-ethylhexyl) maleate

    		Biochemical Assay Reagents Others
    Bis(2-ethylhexyl) maleate can enhance the water sensitivity of polyvinyl acetate (PVAc) films and improve the tackiness, adhesion, and wash resistance of polyacrylate .
    Bis(2-ethylhexyl) maleate
  • HY-D1424
    Coelenterazine hcp

    		Fluorescent Dye Others
    Coelenterazine hcp is a Coelenterazine analogue. Coelenterazine hcp shows high sensitivity to Ca 2+. Coelenterazine hcp is suited for monitoring intracellular Ca 2+ .
    Coelenterazine hcp
  • HY-148913
    CS587

    		CaMK Neurological Disease
    CS587 is a specific inhibitor of CaMK1D with neurocytotoxicity at 10 μM. CS587 modulates the sensitivity of neuronal cells to Aβ oligomer toxicity .
    CS587
  • HY-N8522
    9,10-Dihydroxystearic acid

    		Others Metabolic Disease
    9,10-Dihydroxystearic acid is an oxidation product of oleic acid. 9,10-Dihydroxystearic acid can improve glucose tolerance and insulin sensitivity in KKAy mice .
    9,10-Dihydroxystearic acid
  • HY-158464
    Fetuin glycoprotein

    		Biochemical Assay Reagents Others
    Fetuin glycoprotein is a N-polysaccharide protein and a multifunctional fluorescent linker. The resulting conjugates exhibit high sensitivity and specificity by mimicking the antennal elements of N-glycans .
    Fetuin glycoprotein
  • HY-158977
    β-Lactamase-IN-9

    		Beta-lactamase Bacterial Infection
    β-Lactamase-IN-9 (compound 2) is a β-lactamase inhibitor that can restore the sensitivity of pathogens to β-lactam antibiotics .
    β-Lactamase-IN-9
  • HY-P1004
    Luciferase

    		Reactive Oxygen Species Cancer
    Luciferase from Vibrio fischeri has also been used in a study to investigate the sensitivity of dark mutants of various strains of luminescent bacteria to reactive oxygen species.
    Luciferase

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