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Results for "

reactive activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Reactive Oxygen Species (78) Adenosine Receptor (1) AIM2 (1) Akt (4) AMPK (1) Amyloid-β (1) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (1) Antibiotic (3) Apoptosis (45) Arenavirus (1) Aurora Kinase (1) Autophagy (12) Bacterial (16) Bcl-2 Family (2) Bcr-Abl (1) Biochemical Assay Reagents (4) Btk (1) c-Myc (2) Caspase (1) CDK (1) Cholinesterase (ChE) (4) ClpP (1) COX (3) Cyclophilin (1) Cytochrome P450 (3) Dihydroorotate Dehydrogenase (1) Disulfidptosis (1) DNA/RNA Synthesis (3) Drug Metabolite (1) E1/E2/E3 Enzyme (1) EGFR (2) Endogenous Metabolite (8) ERK (3) Ferroptosis (10) FLT3 (1) Fluorescent Dye (1) Fungal (10) Glutathione Peroxidase (2) HDAC (2) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (1) IAP (1) Influenza Virus (1) Interleukin Related (1) Isotope-Labeled Compounds (2) JAK (2) JNK (1) Keap1-Nrf2 (5) Lactate Dehydrogenase (1) LDLR (2) LPL Receptor (1) MAGL (3) MAP3K (2) MDM-2/p53 (3) Melanocortin Receptor (1) Microtubule/Tubulin (7) Mitochondrial Metabolism (5) MMP (4) Monoamine Oxidase (2) NF-κB (6) NKCC (1) NO Synthase (2) NOD-like Receptor (NLR) (1) p38 MAPK (3) Paraptosis (2) Parasite (5) PDHK (1) Phosphatase (2) Photosensitizer (1) PI3K (4) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (1) Poly(ADP-ribose) Glycohydrolase (PARG) (2) Protease Activated Receptor (PAR) (1) Proteasome (1) Ras (1) ROS Kinase (3) SARS-CoV (3) Ser/Thr Protease (1) STAT (3) Stearoyl-CoA Desaturase (SCD) (1) STING (1) Survivin (1) Tau Protein (2) TGF-beta/Smad (1) TGF-β Receptor (1) TNF Receptor (2) Topoisomerase (2) TRP Channel (1) TrxR (1) Tyrosinase (1) VDAC (1) VEGFR (1)
By Research Areas:	Cancer (83) Cardiovascular Disease (6) Infection (31) Inflammation/Immunology (46) Metabolic Disease (19) Neurological Disease (15)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Nucleotides and their Analogs (1)

165

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Reactive Oxygen Species

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0878

TAPSO	Biochemical Assay Reagents	Others
TAPSO is a common biological buffer, a pH stabilization reagent, with effective pH ranging from 7-8, and pKa values ranging from 7.5–9.0. TAPSO contains Tris groups and exhibits quite reactive activity with zwitterionic glycine peptides .

HY-N8253

Spiraeoside Quercetin 4′-O-glucoside	Reactive Oxygen Species	Inflammation/Immunology Cancer
Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities .

HY-N4161

Euparin	Reactive Oxygen Species	Infection Neurological Disease
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects .

HY-149723

Ferroptosis-IN-5	Ferroptosis	Cancer
Ferroptosis-IN-5 (compound 9c) is a ferroptosis inhibitor with iron-chelating and reactive oxygen species (ROS) scavenging activities .

HY-168565

Tubulin polymerization-IN-70	Apoptosis Microtubule/Tubulin Reactive Oxygen Species	Cancer
Tubulin polymerization-IN-70 (compound Q19) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-70 shows antiproliferative activity. Tubulin polymerization-IN-70 target the colchicine binding site of tubulin and inhibited tubulin polymerization. Tubulin polymerization-IN-70 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-70 induces mitochondrial membrane potential decrease and increases the levels of reactive oxygen species (ROS). Tubulin polymerization-IN-70 shows antiangiogenic and anticancer activity .

HY-116920

Alyssin	Reactive Oxygen Species Microtubule/Tubulin	Cancer
Alyssin, found in Cruciferous Vegetables, exerts anticancer activity in HepG2 by increasing intracellular reactive oxygen species and tubulin depolymerization .

HY-167814

Trimethylsilyl-D-(+)-mannitol	Biochemical Assay Reagents
Trimethylsilyl-D-(+)-mannitol is a compound with osmoprotective activity that can effectively scavenge reactive oxygen species (ROS) and provide protection for plants and microorganisms.

HY-161407

AURKA-IN-1	Aurora Kinase	Cancer
AURKA-IN-1 (compound 9) is an cell-active covalent AURKA inhibitor. AURKA-IN-1 is a lysine-reactive activity probe .

HY-137155

Dapsone hydroxylamine DDS-NOH	Reactive Oxygen Species	Inflammation/Immunology
Dapsone hydroxylamine (DDS-NOH) induces methemoglobinemia. Dapsone hydroxylamine inhibits catalase (CAT) activity and reactive oxygen species generation. Dapsone hydroxylamine also has anti-inflammatory activity .

HY-134235

PAF C-16 carboxylic acid Acetyl-CPGPC	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
PAF C-16 carboxylic acid (Acetyl-CPGPC) is a phospholipid that possesses haptenic activity causing production of antibodies reactive with platelet-activating factor (PAF) .

HY-119502

Camalexin 2 Publications Verification	Reactive Oxygen Species Fungal Bacterial	Infection Cancer
Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production .

HY-116920A

(R)-Alyssin	Reactive Oxygen Species Microtubule/Tubulin	Cancer
(R)-Alyssin is a enantiomer of Alyssin (HY-116920). Alyssin, found in Cruciferous Vegetables, exerts anticancer activity in HepG2 by increasing intracellular reactive oxygen species and tubulin depolymerization .

HY-116920B

(S)-Alyssin	Reactive Oxygen Species Microtubule/Tubulin	Cancer
(S)-Alyssin is a enantiomer of Alyssin (HY-116920). Alyssin, found in Cruciferous Vegetables, exerts anticancer activity in HepG2 by increasing intracellular reactive oxygen species and tubulin depolymerization .

HY-136901

Fusarochromanone FC-101	Reactive Oxygen Species	Cardiovascular Disease Cancer
Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity . Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) .

HY-121204

Iberverin 3-Methylthiopropyl isothiocyanate	Apoptosis Reactive Oxygen Species	Cancer
Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species .

HY-W041080

3,5-Di-tert-butylphenol	Fungal Reactive Oxygen Species	Infection
3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of reactive oxygen species (ROS).

HY-N0578

Apigenin 7-glucoside 3 Publications Verification Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigetrin	Reactive Oxygen Species	Cancer
Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS) .

HY-N8253R

Spiraeoside (Standard)	Reactive Oxygen Species	Inflammation/Immunology Cancer
Spiraeoside (Standard) is the analytical standard of Spiraeoside. This product is intended for research and analytical applications. Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities .

HY-19988

THZ1-R 3 Publications Verification	CDK	Cancer
THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a K_d of 142 nM.

HY-162784

CYP51-IN-19	Fungal Cytochrome P450	Infection
CYP51-IN-19 (compound C07) is a potent CYP51 inhibitor. CYP51-IN-19 stimulates reactive oxygen species (ROS) and exhibits potent fungicidal activity .

HY-N2896

Arjunolic acid	Reactive Oxygen Species	Inflammation/Immunology
Arjunolic acid is a saponin isolated from Cyclocarya paliurus and has various biologial activities, including antioxidant, antimicrobial, antibacterial and anti-inflammory activities. Arjunolic acid is also a potent antioxidant and plays an important role in the protection of cells and tissues against deleterious effects of reactive oxygen species .

HY-N1195

Sugiol (+)-Sugiol; 10-Deoxoxanthoperol	p38 MAPK ERK JNK Interleukin Related TNF Receptor	Inflammation/Immunology
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .

HY-169416

Anti-MRSA agent 21	Bacterial Reactive Oxygen Species	Infection
Anti-MRSA agent 21 (Compound 27) has antibacterial activity against MRSA, with an MIC of 1 μM. Anti-MRSA agent 21 can damage bacterial cell membranes and increase reactive oxygen species .

HY-156843

Antiproliferative agent-38	Others	Cancer
Antiproliferative agent-38 (com 18) is a tetracyclic ring, but its most reactive ring nitrogen (probably the quinoline moiety) cannot undergo N-alkylation. Antiproliferative agent-38 lacks anti-malarial activity and lacks anti-cancer cell proliferation activity .

HY-115502A

BCI hydrochloride 5+ Cited Publications (E)-BCI hydrochloride	Phosphatase	Inflammation/Immunology
BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research .

HY-115502

BCI 5+ Cited Publications (E)-BCI	Phosphatase	Inflammation/Immunology
BCI ((E)-BCI) is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research .

HY-N11887

Linocinnamarin	Reactive Oxygen Species	Inflammation/Immunology
Linocinnamarin is a nature product that could be isolated from Fragaria ananassa Duch. Linocinnamarin has anti-inflammatory activity. Linocinnamarin inhibits antigen-stimulated elevation of intracellular free Ca ²⁺ concentration and reactive oxygen species (ROS) .

HY-158023

DHODH-IN-26	Dihydroorotate Dehydrogenase Reactive Oxygen Species Ferroptosis	Cancer
DHODH-IN-26 (compound B2) is a mitochondria-targeting DHODH inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces ferroptosis .

HY-B1977

Dipropetryn GS 16068; Sancap; Cotofor	Others	Others
Dipropetryn (GS 16068) is a compound that inhibits algal photosynthesis and toxin production. It can reduce the photosynthetic activity and pigment content of Karenia, reduce the levels of unsaturated fatty acids, reactive oxygen and hemolytic toxins, and regulate the expression of related proteins.

HY-W402074

5-Acetamide-Butenolide Butenolide	Mitochondrial Metabolism Reactive Oxygen Species	Metabolic Disease
5-Acetamide-Butenolide (Butenolide) is a mycotoxin with pro-oxidant activity, which is found in Fusarium. 5-Acetamide-Butenolide disrupts the mitochondrial membrane potential in primary neonatal rat cardiomyocytes. 5-Acetamide-Butenolide also induces the production of thiobarbituric acid reactive substances (TBARS) in isolated rat myocardial mitochondria. 5-Acetamide-Butenolide increases the production of reactive oxygen species (ROS), decreases the levels of GSH and reduces the viability of HepG2 cells .

HY-N6884

Bixin 1 Publications Verification	Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology Cancer
Bixin (BX), isolated from the seeds of Bixa orellana, is a carotenoid, possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation .

HY-111278

Pyocyanin 1 Publications Verification Pyocyanine; Sanazin; Sanasin	Reactive Oxygen Species Bacterial Drug Metabolite Endogenous Metabolite	Infection Inflammation/Immunology
Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity .

HY-116895

JJH260	Androgen Receptor MAGL	Metabolic Disease
JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC₅₀ values of 0.50 μM and 0.57 μM, respectively .

HY-P4161

KWWCRW	DNA/RNA Synthesis	Cancer
KWWCRW is a Holliday linker inhibitory peptide with anticancer activity. KWWCRW inhibits homologous recombination repair (HDR) during DNA repair by binding to the reactive Holliday linker intermediate and preventing its degradation, and inhibits site-specific recombination by bacteriophage in vitro .

HY-N0692

Schisandrol B 2 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Reactive Oxygen Species Cytochrome P450 Autophagy	Cancer
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-131697

FeTPPS	NO Synthase Apoptosis	Inflammation/Immunology
FeTPPS, a 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrin iron III chloride peroxynitrite decomposition catalyst, possesses evident neuroprotective effects in a experimental model of spinal cord damage . FeTPPS acts as a peroxynitrite scavenger and anti-nitrating agent in vivo. FeTPPS reduces nitric oxide (NO) production and apoptosis process .

HY-125143

ABC34	MAGL	Metabolic Disease
ABC34 is an inactive control compound of JJH260. ABC34 does not inhibit the fluorophosphonate reactivity or fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1. ABC34 can inhibit both ABHD6 and PPT122 .

HY-N12267

N,N′-Diferuloylputrescine (E/Z)-Terrestribisamide	Melanocortin Receptor	Metabolic Disease
N,N′-Diferuloylputrescine ((E/Z)-Terrestribisamide) is a inhibitor of pigmentation with 57% reduction. N,N′-Diferuloylputrescine significantly reduces the protein level of MITF. N,N′-Diferuloylputrescine has strong antioxidant activities as radical scavengers against reactive oxygen species .

HY-122005

AVE-9488	NO Synthase	Inflammation/Immunology
AVE-9488 is an eNOS enhancer with the activity of protecting the heart from ischemia-reperfusion injury. AVE-9488 can upregulate eNOS expression, increase NO production, reduce myocardial ischemia-reperfusion injury, and reduce the level of reactive oxygen species .

HY-Y0445A

Sodium dichloroacetate 15+ Cited Publications	PDHK Reactive Oxygen Species NKCC Apoptosis	Cancer
Sodium dichloroacetate is a metabolic regulator in cancer cells' mitochondria with anticancer activity. Sodium dichloroacetate inhibits PDHK, resulting in decreased lactic acid in the tumor microenvironment. Sodium dichloroacetate increases reactive oxygen species (ROS) generation and promotes cancer cell apoptosis. Sodium dichloroacetate also works as NKCC inhibitor .

HY-158412

BT317	Proteasome Apoptosis	Cancer
BT317 is a blood-brain transmissible mitochondrial Lon peptidase I (LonP1) and CT-L proteasome inhibitor. BT317 can increase the production of reactive oxygen species (ROS) and induce apoptosis in astrocytoma cells. BT317 has antitumor activity .

HY-N0501

11-oxo-mogroside V	Reactive Oxygen Species	Metabolic Disease
11-oxo-mogroside V is a natural sweetener that exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O₂ ^-, H₂O₂ and OH) with EC₅₀* of 4.79, 16.52, and 146.17 μg/mL, respectively.

HY-N1306

Sideroxylin	Bacterial Reactive Oxygen Species Apoptosis	Infection Cancer
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against *Staphylococcus aureus. Sideroxylin inhibits ovarian cancer cell proliferation and induces apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive* oxygen species (ROS) .

HY-N10431

Stigmane B	Keap1-Nrf2	Neurological Disease
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-N6807

Elemicin	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial	Infection Cancer
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-128784

PK11007	MDM-2/p53 Reactive Oxygen Species	Cancer
PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels .

HY-130439

EUK-124	Others	Metabolic Disease
EUK 8 and EUK 134 are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity.1 EUK 124 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 124 and EUK 8 inhibit superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity), with IC₅₀ values of 5 μM and 0.7 μM, respectively.

HY-100768

HTHQ 2 Publications Verification 1-O-hexyl-2,3,5-trimethylhydroquinone; HX-1171; BTT-105	Reactive Oxygen Species	Cancer
HTHQ (1-O-hexyl-2,3,5-trimethylhydroquinone) is a potent lipophilic phenolic antioxidant. HTHQ has considerable anti-oxidative activity by directly reacting with reactive oxygen species (ROS) and scavenging ROS to form more stable free radicals .

HY-N3562

Cedrin	Reactive Oxygen Species	Neurological Disease
Cedrin is a natural flavonoid that can be found in Cedrus deodara. Cedrin protects PC12 cells against neurotoxicity induced by Aβ1-42. Cedrin can reduce reactive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content .

HY-W075770

Nickel(II) oxide Nickel monoxide	Bacterial Reactive Oxygen Species	Infection Metabolic Disease Cancer
Nickel(II) oxide is a chemical compound which nanoparticle form (NiO NPs) exhibits antibacterial, antifungal, antileishmanial, anti-diabetic and anticancer activities. NiO NPs can be activated by ultraviolet and visible light to generate reactive oxygen species, which may be the main cause for the antimicrobial potential .

Cat. No.	Product Name

HY-L051

Ferroptosis Compound Library

1,118 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 1,118 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

HY-L046

Anti-Cardiovascular Disease Compound Library

1,797 compounds

Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk.

MCE supplies a unique collection of 1,797 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.

Cat. No.	Product Name	Type

HY-146248

TFMU-ADPr

Chromogenic Substrates

TFMU-ADPr is a general substrate for monitoring poly(ADP-ribose) glycohydrolase (PARG) activity. TFMU-ADPr can directly report on total PAR hydrolase activity via release of a fluorophore. TFMU-ADPr has excellent reactivity, generality, stability, and usability. TFMU-ADPr is a versatile tool for assessing small-molecule inhibitors in vitro and probing the regulation of ADP-ribosyl catabolic enzymes .

Cat. No.	Product Name	Type

HY-D0878

TAPSO	Biochemical Assay Reagents
TAPSO is a common biological buffer, a pH stabilization reagent, with effective pH ranging from 7-8, and pKa values ranging from 7.5–9.0. TAPSO contains Tris groups and exhibits quite reactive activity with zwitterionic glycine peptides .

HY-167814

Trimethylsilyl-D-(+)-mannitol	Cell Assay Reagents
Trimethylsilyl-D-(+)-mannitol is a compound with osmoprotective activity that can effectively scavenge reactive oxygen species (ROS) and provide protection for plants and microorganisms.

HY-137496

4-Methylumbelliferyl β-D-mannopyranoside	Enzyme Substrates
4-Methylumbelliferyl β-D-mannopyranoside is a substrate that exhibits β-mannosidase activity. 4-Methylumbelliferyl β-D-mannopyranoside can be used to study β-mannosidase deficiency. The reactivity of 4-Methylumbelliferyl β-D-mannopyranoside shows different inhibitory effects on various substrates.

Cat. No.	Product Name	Target	Research Area

HY-P4052

Pinealon	ROS Kinase	Neurological Disease
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia .

HY-P4161

KWWCRW	DNA/RNA Synthesis	Cancer
KWWCRW is a Holliday linker inhibitory peptide with anticancer activity. KWWCRW inhibits homologous recombination repair (HDR) during DNA repair by binding to the reactive Holliday linker intermediate and preventing its degradation, and inhibits site-specific recombination by bacteriophage in vitro .

Cat. No.	Product Name	Target	Research Area

HY-P99742

Mitazalimab ADC-1013; JNJ-64457107	TNF Receptor	Cancer
Mitazalimab (ADC-1013; JNJ-64457107) is FcγR-dependent CD40 agonist with tumor-directed activity. Mitazalimab activates antigen-presenting cells, e.g. dendritic cells (DC), to initiate tumor-reactive T cells. Therefore, Mitazalimab induces tumor-specific T cells to infiltrate and kill tumors. Mitazalimab remodels the tumor-infiltrating myeloid microenvironment .

HY-P99359

Elezanumab ABT-555; AE12-1Y-QL; Anti-RGMA Reference Antibody (elezanumab)	TGF-beta/Smad	Metabolic Disease
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC₅₀ around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8253

Spiraeoside Quercetin 4′-O-glucoside	Structural Classification Flavonoids Liliaceae Classification of Application Fields Flavonones Source classification Phenols Polyphenols Allium cepa L. Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities .

HY-N4161

Euparin	Monophenols Source classification Phenols Plants Compositae Guilandina minax (Hance) G. P. Lewis	Reactive Oxygen Species
Euparin, a monomeric compound of Benzofuran, is a reactive oxygen species (ROS) inhibitor. Euparin shows antiviral activity against poliovirus, and also has antidepressant effects .

HY-119502

Camalexin 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Camelina sativa (L.) Crantz Plants Endogenous metabolite Indole Alkaloids Infection Alkaloids Human Gut Microbiota Metabolites Microorganisms Brassicaceae Disease Research Fields	Reactive Oxygen Species Fungal Bacterial
Camalexin is a phytoalexin isolated from Camelina sativa (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. Camalexin can induce reactive oxygen species (ROS) production .

HY-121204

Iberverin 3-Methylthiopropyl isothiocyanate	Structural Classification Natural Products Cruciferous vegetables Classification of Application Fields Source classification Plants Brassicaceae Disease Research Fields Cancer	Apoptosis Reactive Oxygen Species
Iberverin (-Methylthiopropyl isothiocyanate) is a sulforaphane homolog. Iberverin has anticancer activity. Iberverin inhibits cell proliferation and migration. Iberverin induces mitochondrial-related apoptosis and intracellular reactive oxygen species .

HY-W041080

3,5-Di-tert-butylphenol	Infection Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	Fungal Reactive Oxygen Species
3,5-Di-tert-butylphenol is an volatile organic compound with anti-biofilm and antifungal activities. 3,5-Di-tert-butylphenol induces accumulation of reactive oxygen species (ROS).

HY-N0578

Apigenin 7-glucoside 3 Publications Verification Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigetrin	Structural Classification Flavonoids Classification of Application Fields Flavones Source classification Dendranthema morifolium (Ramat.) Tzvel. Phenols Polyphenols Plants Compositae Disease Research Fields Cancer	Reactive Oxygen Species
Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS) .

HY-N2896

Arjunolic acid	Triterpenes Structural Classification Classification of Application Fields Juglandaceae Terpenoids Source classification Cyclocarya paliurus (Batal.) Iljinsk. Plants Inflammation/Immunology Disease Research Fields	Reactive Oxygen Species
Arjunolic acid is a saponin isolated from Cyclocarya paliurus and has various biologial activities, including antioxidant, antimicrobial, antibacterial and anti-inflammory activities. Arjunolic acid is also a potent antioxidant and plays an important role in the protection of cells and tissues against deleterious effects of reactive oxygen species .

HY-N1195

Sugiol (+)-Sugiol; 10-Deoxoxanthoperol	Structural Classification Cupressaceae Terpenoids Diterpenoids Calocedrus formosana (Florin) Florin Plants	p38 MAPK ERK JNK Interleukin Related TNF Receptor
Sugiol is an abietane diterpenoid, can be isolated from Calocedrus formosana bark. Sugiol has anti-inflammatory activity, could effectively reduce intracellular reactive oxygen species (ROS) production in lipopolysaccharide (LPS)-stimulated macrophages .

HY-136901

Fusarochromanone FC-101	Cardiovascular Disease Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Reactive Oxygen Species
Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity . Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS) .

HY-N8253R

Spiraeoside (Standard)	Structural Classification Flavonoids Liliaceae Flavonones Source classification Phenols Polyphenols Allium cepa L. Plants	Reactive Oxygen Species
Spiraeoside (Standard) is the analytical standard of Spiraeoside. This product is intended for research and analytical applications. Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities .

HY-N11887

Linocinnamarin	Structural Classification Natural Products Source classification Rosaceae Plants Fragaria × ananassa Duch.	Reactive Oxygen Species
Linocinnamarin is a nature product that could be isolated from Fragaria ananassa Duch. Linocinnamarin has anti-inflammatory activity. Linocinnamarin inhibits antigen-stimulated elevation of intracellular free Ca ²⁺ concentration and reactive oxygen species (ROS) .

HY-N6884

Bixin 1 Publications Verification	Bixaceae Bixa orellana Linn. Classification of Application Fields Ketones, Aldehydes, Acids Source classification Pigments Plants Inflammation/Immunology Disease Research Fields Cancer Food Research	Reactive Oxygen Species
Bixin (BX), isolated from the seeds of Bixa orellana, is a carotenoid, possessing anti-inflammatory, anti-tumor and anti-oxidant activities. Bixin treatment ameliorated cardiac dysfunction through inhibiting fibrosis, inflammation and reactive oxygen species (ROS) generation .

HY-111278

Pyocyanin 1 Publications Verification Pyocyanine; Sanazin; Sanasin	Microorganisms Source classification	Reactive Oxygen Species Bacterial Drug Metabolite Endogenous Metabolite
Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity .

HY-N0692

Schisandrol B 2 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Reactive Oxygen Species Cytochrome P450 Autophagy
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-N12267

N,N′-Diferuloylputrescine (E/Z)-Terrestribisamide	Structural Classification Zea mays L. Gramineae Source classification Phenols Polyphenols Plants	Melanocortin Receptor
N,N′-Diferuloylputrescine ((E/Z)-Terrestribisamide) is a inhibitor of pigmentation with 57% reduction. N,N′-Diferuloylputrescine significantly reduces the protein level of MITF. N,N′-Diferuloylputrescine has strong antioxidant activities as radical scavengers against reactive oxygen species .

HY-N0501

11-oxo-mogroside V	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Sweeteners Food Research	Reactive Oxygen Species
11-oxo-mogroside V is a natural sweetener that exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O₂ ^-, H₂O₂ and OH) with EC₅₀* of 4.79, 16.52, and 146.17 μg/mL, respectively.

HY-N1306

Sideroxylin	Infection Eucalyptus saligna Flavonoids Classification of Application Fields Flavones Source classification Phenols Polyphenols Myrtaceae Plants Disease Research Fields	Bacterial Reactive Oxygen Species Apoptosis
Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against *Staphylococcus aureus. Sideroxylin inhibits ovarian cancer cell proliferation and induces apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive* oxygen species (ROS) .

HY-N10431

Stigmane B	Zea mays L. Terpenoids Gramineae Source classification Diterpenoids Plants	Keap1-Nrf2
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-N6807

Elemicin	Infection Asarum sieboldii Miq. Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Phenylpropanoids Plants Disease Research Fields Aristolochiaceae	Stearoyl-CoA Desaturase (SCD) Influenza Virus Bacterial
Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

HY-N3562

Cedrin	Structural Classification Cedrus deodara (Roxburgh) G. Don Flavonoids Neurological Disease Classification of Application Fields Pinaceae Flavonones Source classification Plants Disease Research Fields	Reactive Oxygen Species
Cedrin is a natural flavonoid that can be found in Cedrus deodara. Cedrin protects PC12 cells against neurotoxicity induced by Aβ1-42. Cedrin can reduce reactive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content .

HY-121014

Amphimedine	Structural Classification Alkaloids Marine natural products Source classification Pyridine Alkaloids Sponge	Reactive Oxygen Species
Amphimedine is a polycyclic alkaloid isolated from the marine sponge Amphimedon sp. and belongs to the pyridoindole alkaloid class. Amphimedine has cytotoxic activity and has been studied as an anticancer metabolite along with neoamphimedine. Studies have shown that deoxyamphimedine damages DNA by generating reactive oxygen species, a mechanism different from that of amphimedine.

HY-N3149

(E)-2-Hydroxycinnamaldehyde	Structural Classification Monophenols Cinnamomum cassia (L.) D. Don Source classification Phenols Plants Lauraceae	STAT Apoptosis Reactive Oxygen Species
(E)-2-Hydroxycinnamaldehyde is an aldehyde that can be separated from the stem bark of cinnamon. (E)-2-Hydroxycinnamaldehyde inhibits cell proliferation and induces apoptosis by inhibiting signal transduction of STAT3 and reactive oxygen species production. (E)-2-Hydroxycinnamaldehyde has antitumor activity .

HY-N10611

Elsinochrome A	Structural Classification Natural Products Microorganisms Source classification	Reactive Oxygen Species Apoptosis Autophagy Fungal Fluorescent Dye
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm) .

HY-N0801

Polygalacic acid	Triterpenes Terpenoids Source classification Polygalaceae Plants Polygala tenuifolia Willd.	MMP Cholinesterase (ChE)
Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex .

HY-N0692R

Schisandrol B (Standard)	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Reactive Oxygen Species Cytochrome P450 Autophagy
Schisandrol B (Standard) is the analytical standard of Schisandrol B. This product is intended for research and analytical applications. Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-N0578R

Apigenin 7-glucoside (Standard)	Structural Classification Flavonoids Flavones Source classification Dendranthema morifolium (Ramat.) Tzvel. Phenols Polyphenols Plants Compositae	Reactive Oxygen Species
Apigenin 7-glucoside (Standard) is the analytical standard of Apigenin 7-glucoside. This product is intended for research and analytical applications. Apigenin-7-glucoside (Apigenin-7-O-β-D-glucopyranoside) exhibits significant anti-proliferative and antioxidant activity and scavenges reactive oxygen species (ROS) .

HY-N10443

Mammea A/BA	other families Source classification Coumarins Phenylpropanoids Plants Calophyllum brasiliense auct. non Camb.	Parasite Apoptosis Autophagy Reactive Oxygen Species
Mammea A/BA has potent activity against Trypanosoma cruzi (T. cruzi). Mammea A/BA induces mitochondrial dysfunction, reactive oxygen species (ROS) production and DNA fragmentation, and increases number of acidic vacuoles. Mammea A/BA can induce apoptosis, autophagy and necrosis. Mammea A/BA can be used for researching chagas disease .

HY-167685

(E/Z)-Aureusidin	Source classification Plants Plumbaginaceae	Bacterial
(E/Z)-Aureusidin is a flavonoid compound with antioxidant activity. (E/Z)-Aureusidin can inhibit the production of reactive oxygen species and reduce cell damage. (E/Z)-Aureusidin has anti-inflammatory effects and can reduce the expression of inflammatory factors. (E/Z)-Aureusidin has inhibitory effects on a variety of bacteria, indicating its potential antimicrobial properties .

HY-N0411

β-Carotene 1 Publications Verification Provitamin A; beta-Carotene	Structural Classification Classification of Application Fields Source classification Endocrine diseases Metabolic Disease Plants Endogenous metabolite Food Research Other Terpenoids Immune System Disorder other families Terpenoids Disease markers Pigments Disease Research Fields Cancer	Endogenous Metabolite Apoptosis Reactive Oxygen Species
β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .

HY-N3243

Moracin P 2 Publications Verification	Structural Classification other families Neurological Disease Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species
Moracin P is a 2-arylbenzofuran isolated from the Mori Cortex Radicis. Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin P reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin P has neuroprotective and anti-inflammatory effects .

HY-N3244

Moracin O 2 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	HIF/HIF Prolyl-Hydroxylase Reactive Oxygen Species
Moracin O is a 2-arylbenzofuran isolated from the Morus alba Linn. . Moracin O exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1). Moracin O reduces oxygen-glucose deprivation (OGD)-induced reactive oxygen species (ROS) production. Moracin O has neuroprotective and anti-inflammatory effects .

HY-W748509

Pipernonaline	Piper longum Linn. Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-N12788

T-Cadinol	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Casearia sylvestris Sw. Salicaceae	Parasite
T-Cadinol is a sesquiterpene isolated from C. sylvestris that exhibits anti-Trypanosoma cruzi activity, with IC₅₀ values of 18.2 μM and 15.8 μM against trypomastigote and amastigote forms, respectively. T-Cadinol can induce mitochondrial damage in parasites, leading to membrane hyperpolarization and decreased levels of reactive oxygen species. T-Cadinol can be used for the research of Chagas disease .

HY-13065

Isobavachalcone Maximum Cited Publications 8 Publications Verification Corylifolinin; Isobacachalcone	Structural Classification Classification of Application Fields Source classification Plants Chalcones Flavonoids Leguminosae Phenols Polyphenols Psoralea corylifolia L. Glycyrrhiza uralensis Fisch. Disease Research Fields Cancer	Akt Reactive Oxygen Species Apoptosis Autophagy
Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC₅₀ value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .

HY-N10113

Verrucarin J Muconomycin B	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Marine algae Marine natural products Source classification Disease Research Fields	Apoptosis Arenavirus Fungal Antibiotic Reactive Oxygen Species
Verrucarin J (Muconomycin B) is a metabolite of the Myrothecium fungus family. Verrucarin J generates reactive oxygen species (ROS) and induces apoptosis of cancer cell lines, such as A549, HCT 116 and SW-620 cells. Verrucarin J shows activities against Candida albicans and Mucor miehei. Verrucarin J inhibits arenavirus Junin (JUNV) yield with an IC₅₀ of 1.2 ng/mL .

HY-N6947

Lutein 4 Publications Verification Xanthophyll	Structural Classification Classification of Application Fields Source classification Whitening Agent Food Research Microorganisms Animals Terpenoids Pigments Diterpenoids Cosmetic Research Inflammation/Immunology Disease Research Fields	Endogenous Metabolite Apoptosis Reactive Oxygen Species
Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health . Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS) . Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active .

HY-N0501R

11-oxo-mogroside V (Standard)	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants	Reactive Oxygen Species
11-oxo-mogroside V (Standard) is the analytical standard of 11-oxo-mogroside V. This product is intended for research and analytical applications. 11-oxo-mogroside V is a natural sweetener that exhibits strong antioxidant activity. It exhibits significant inhibitory effects on reactive oxygen species (O2-, H2O2 and OH) with EC₅₀* of 4.79, 16.52, and 146.17 μg/mL, respectively.

HY-N2360

Hinokiflavone 3 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	E1/E2/E3 Enzyme Apoptosis MMP ClpP
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC₅₀ value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-136409

N-Decanoyl-L-homoserine lactone C10-HSL	Microorganisms Source classification	Bacterial Reactive Oxygen Species
N-decanoyl-L-homoserine lactone (C10-HSL) is a N-acyl-homoserine lactone (AHL) N-decanoyl-L-homoserine lactone can inhibit primary root growth in Arabidopsis. N-decanoyl-L-homoserine lactone triggers a transient and immediate increase in the concentrations of cytosolic free Ca ²⁺ and reactive oxygen species (ROS), increases the activity of mitogen-activated protein kinase 6 (MPK6), and induces nitric oxide (NO) production in Arabidopsis roots .

HY-N0411R

β-Carotene (Standard)	Other Terpenoids Structural Classification Immune System Disorder other families Terpenoids Source classification Disease markers Endocrine diseases Plants Endogenous metabolite Cancer	Endogenous Metabolite Apoptosis Reactive Oxygen Species
β-Carotene (Standard) is the analytical standard of β-Carotene. This product is intended for research and analytical applications. β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .

HY-D0885

Phosphocreatine 1 Publications Verification Creatine phosphate; Creatinephosphoric acid	Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase
Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and *ROS (Reactive* Oxygen Species) generation through ERK** mediated mediated Nrf-2/HO-1 pathway. .

HY-D0885C

Phosphocreatine dipotassium Creatine phosphate dipotassium; Creatinephosphoric acid dipotassium	Structural Classification Animals Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite MAP3K Akt Mitochondrial Metabolism ERK Apoptosis ROS Kinase
Phosphocreatine (creatine phosphate) is an organic compound found in vertebrate skeletal muscles. Phosphocreatine enhances antioxidant activity, and activates the TAK1 pathway to protect the heart. Phosphocreatine normalizing mitochondrial function and reducing oxidative stress via Akt mediated Nrf2/HO-1 pathway. Phosphocreatine provides renal protection by suppressing Apoptosis and *ROS (Reactive* Oxygen Species) generation through ERK** mediated mediated Nrf-2/HO-1 pathway. .

HY-13065R

Isobavachalcone (Standard)	Structural Classification Chalcones Flavonoids Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants Glycyrrhiza uralensis Fisch.	Akt Reactive Oxygen Species Apoptosis Autophagy
Isobavachalcone (Standard) is the analytical standard of Isobavachalcone. This product is intended for research and analytical applications. Isobavachalcone (Corylifolinin) is derived from Psoralea corylifolia Linn. and is a potent inhibitor of Akt signaling pathway, which induces apoptosis in human cancer cells (Inhibits OVCAR-8 cell growth with an IC50 value of 7.92 μM). Isobavachalcone also induces Reactive Oxyen Species (ROS) generation in OVCAR-8 cells and has exhibit cancer anti-promotive and anti-proliferative activity .

HY-18061R

Ochromycinone (Standard)	Quinones Structural Classification Monophenols Microorganisms Anthraquinones Source classification Phenols	Antibiotic STAT Bacterial
Lutein (Standard) is the analytical standard of Lutein. This product is intended for research and analytical applications. Lutein (Xanthophyll) is a carotenoid with reported anti-inflammatory properties. A large body of evidence shows that lutein has several beneficial effects, especially on eye health . Lutein exerts its biological activities, including anti-inflammation, anti-oxidase and anti-apoptosis, through effects on reactive oxygen species (ROS) . Lutein is able to arrive in the brain and shows antidepressant-like and neuroprotective effects. Lutein is orally active .

HY-N1913

Danshensu 3 Publications Verification Dan shen suan A; Salvianic acid A	Structural Classification Classification of Application Fields Simple Phenylpropanols Labiatae Samanea saman (Jacq.) Merr. Source classification Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Cancer	Keap1-Nrf2 NF-κB Reactive Oxygen Species SARS-CoV Apoptosis
Danshensu (Dan shen suan A), an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-N1913A

Danshensu sodium 3 Publications Verification Dan shen suan A sodium; Salvianic acid A sodium	Structural Classification Simple Phenylpropanols Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Phenylpropanoids Plants	Keap1-Nrf2 NF-κB Reactive Oxygen Species SARS-CoV Apoptosis
Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC₅₀ of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research .

HY-N0330

Momordin Ic 3 Publications Verification	Kochia scoparia L. Schrad. Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Chenopodiaceae Cancer	Apoptosis Autophagy PI3K c-Myc
Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl₄ (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

HY-N2515

Ginsenoside Rk1 5+ Cited Publications	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-112356

Scytonemin	Structural Classification Alkaloids Microorganisms Classification of Application Fields Sunscreen Source classification Cosmetic Research Indole Alkaloids	Apoptosis Reactive Oxygen Species Polo-like Kinase (PLK)
Scytonemin is a hydrophobic alkaloid pigment that can be isolated from the outer sheath of cyanobacteria. Scytonemin has protective function against short-wave solar ultraviolet (UV) radiation, which can reduce the generation of reactive oxygen species (ROS) and the formation of DNA damage. Scytonemin also has anti-inflammatory and anti-proliferative activities, produces concentration-dependent inhibition (IC₅₀=2.0 μM) of polo-like kinase 1 (PLK1)-mediated cdc25C phosphorylation, and plays an important role in regulating the G2/M transition in the cell cycle. It can be used in the research of cancer, acute inflammation and sunscreen cosmetics .

HY-N0330R

Momordin Ic (Standard)	Kochia scoparia L. Schrad. Triterpenes Structural Classification Terpenoids Source classification Plants Chenopodiaceae	Apoptosis Autophagy PI3K c-Myc
Momordin Ic (Standard) is the analytical standard of Momordin Ic. This product is intended for research and analytical applications. Momordin Ic is an orally active triterpenoid saponin that can be isolated from Kochia scoparia. It is also a SUMO specific protease 1 (SENP1) inhibitor, SENP1/c-MYC signaling pathway inhibitor, and apoptosis inducer. Momordin Ic induces autophagy and apoptosis in liver cancer cells through the PI3K/Akt and MAPK signaling pathways mediated by reactive oxygen species. Momordin Ic has the ability to control glucose induced blood glucose elevation, inhibit gastric emptying, resist rheumatoid arthritis, reduce CCl4 (HY-Y0298) induced hepatotoxicity and anti-tumor activity .

Cat. No.	Product Name	Chemical Structure

HY-B0190S1

Nafamostat formate salt-13C6
Nafamostat formate salt- ¹³C₆ is the ¹³C labeled Nafamostat. Nafamostat, a synthetic serine protease inhibitor, is an anticoagulant. Nafamostat supresses T cell auto-reactivity by decreasing granzyme activity and CTL cytolysis. Nafamostat blocks activation of SARS-CoV-2 .

HY-W015879S

2-Heptanol-d5
2-Heptanol-d₅ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation .

HY-W013627S

trans,trans-2,4-Decadienal-d4

trans,trans-2,4-Decadienal-d₄ is deuterated labeled Elemicin (HY-N6807). Elemicin is an orally active alkenylbenzene widely distributed in many herbs and spices. Elemicin inhibits Stearoyl-CoA Desaturase 1 (SCD1) by metabolic activation. Elemicin has anti-influenza activities, antimicrobial, antioxidant, and antiviral activities. Elemicin and its reactive metabolite of 1′-Hydroxyelemicin can induce hepatotoxicity .

Cat. No.	Product Name		Classification