Bcl2 - B cell leukemia/lymphoma 2 Gene

Mus musculus

Also known as Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik

Gene ID: 12043 | Gene type: protein coding

About Bcl2

Chromosome 1: 106,465,908-106,642,004 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 230 orthologues, 10 paralogues and is associated with 133 phenotypes. Ubiquitous expression in spleen adult (RPKM 4.5), limb E14.5 (RPKM 2.8) and 23 other tissues.

Summary

This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated Apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and Autophagy. Abnormal expression and chromosomal translocations of this gene are associated with Cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Bcl2 Products(2)

mRNA	Protein	Name
NM_177410.3	NP_803129.2	apoptosis regulator Bcl-2 isoform 2
NM_009741.5	NP_033871.2	apoptosis regulator Bcl-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	36812915	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	7834748	MGI
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	16717086	MGI
enables protein phosphatase binding	IDA IDA: Inferred from direct assay	12617961	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	17382917	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of B cell apoptotic process	IDA IDA: Inferred from direct assay	8313913	MGI
acts upstream of or within B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	8372353	MGI
acts upstream of or within B cell differentiation	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within B cell homeostasis	IMP IMP: Inferred from mutant phenotype	7650488	MGI
acts upstream of or within B cell lineage commitment	IMP IMP: Inferred from mutant phenotype	8788039	MGI
acts upstream of or within CD8-positive, alpha-beta T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12855558	MGI
acts upstream of T cell apoptotic process	IDA IDA: Inferred from direct assay	7751019	MGI
acts upstream of or within T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	8372353	MGI
acts upstream of or within T cell differentiation	IGI IGI: Inferred from genetic interaction	9215624	MGI
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within T cell homeostasis	IGI IGI: Inferred from genetic interaction	17591857	MGI
acts upstream of or within T cell homeostasis	IMP IMP: Inferred from mutant phenotype	7650488	MGI
acts upstream of or within T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	8788039	MGI
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	9950951	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within apoptotic mitochondrial changes	IDA IDA: Inferred from direct assay	14707049	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	7840250	MGI
acts upstream of or within axon regeneration	IDA IDA: Inferred from direct assay	9009190	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	9009190	MGI
acts upstream of or within behavioral fear response	IMP IMP: Inferred from mutant phenotype	16095731	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	14699151	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	16672320	MGI
acts upstream of calcium ion transport into cytosol	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of cell growth	IMP IMP: Inferred from mutant phenotype	12855558	MGI
acts upstream of cell migration	IMP IMP: Inferred from mutant phenotype	15292044	MGI
acts upstream of or within cell morphogenesis	IDA IDA: Inferred from direct assay	18548006	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	10193316	MGI
acts upstream of or within cell population proliferation	IGI IGI: Inferred from genetic interaction	10762311	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	15292044	MGI
acts upstream of or within cellular response to glucose starvation	IDA IDA: Inferred from direct assay	7595537	MGI
acts upstream of or within cellular response to hypoxia	IDA IDA: Inferred from direct assay	7595537	MGI
acts upstream of or within cochlear nucleus development	IMP IMP: Inferred from mutant phenotype	11027399	MGI
acts upstream of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	17267035	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	15818405	MGI
acts upstream of or within developmental pigmentation	IGI IGI: Inferred from genetic interaction	11709185	MGI
acts upstream of or within developmental pigmentation	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	7812968	MGI
acts upstream of or within ear development	IGI IGI: Inferred from genetic interaction	11709185	MGI
acts upstream of or within ear development	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within endoplasmic reticulum calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	10200548	MGI
acts upstream of establishment of localization in cell	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IGI IGI: Inferred from genetic interaction	12082633	MGI
acts upstream of or within focal adhesion assembly	IMP IMP: Inferred from mutant phenotype	15292044	MGI
acts upstream of or within gland morphogenesis	IMP IMP: Inferred from mutant phenotype	7812968	MGI
acts upstream of or within glomerulus development	IMP IMP: Inferred from mutant phenotype	8623928	MGI
involved in hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	8402909	MGI
acts upstream of or within hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	9028316	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	7812968	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	9241272	MGI
acts upstream of or within immune system development	IMP IMP: Inferred from mutant phenotype	7812968	MGI
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	7945396	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IGI IGI: Inferred from genetic interaction	15983387	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	12855558	MGI
acts upstream of or within kidney development	IGI IGI: Inferred from genetic interaction	9241272	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	7812968	MGI
acts upstream of or within leukocyte homeostasis	IMP IMP: Inferred from mutant phenotype	9028316	MGI
acts upstream of lymphocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within lymphocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within lymphocyte homeostasis	IGI IGI: Inferred from genetic interaction	11709185	MGI
acts upstream of or within lymphocyte homeostasis	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within lymphoid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	9028316	MGI
acts upstream of or within male gonad development	IGI IGI: Inferred from genetic interaction	9241272	MGI
acts upstream of or within melanin metabolic process	IMP IMP: Inferred from mutant phenotype	11709185	MGI
acts upstream of or within melanocyte differentiation	IGI IGI: Inferred from genetic interaction	12086670	MGI
acts upstream of melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	16427619	MGI
acts upstream of or within melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	8758925	MGI
acts upstream of or within mesenchymal cell development	IMP IMP: Inferred from mutant phenotype	8623928	MGI
acts upstream of or within metanephros development	IMP IMP: Inferred from mutant phenotype	7840250	MGI
acts upstream of mitotic cell cycle	IDA IDA: Inferred from direct assay	9241272	MGI
acts upstream of motor neuron apoptotic process	IDA IDA: Inferred from direct assay	7472523	MGI
acts upstream of myeloid cell apoptotic process	IDA IDA: Inferred from direct assay	9202146	MGI
acts upstream of or within negative regulation of B cell apoptotic process	IDA IDA: Inferred from direct assay	8313913	MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	14660795	MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12855558	MGI
acts upstream of or within negative regulation of T cell apoptotic process	IDA IDA: Inferred from direct assay	7751019	MGI
acts upstream of or within negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	7834747	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	7834747	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	7840250	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	11546872	MGI
involved in negative regulation of autophagy	IDA IDA: Inferred from direct assay	36812915	MGI
acts upstream of or within negative regulation of calcium ion transport into cytosol	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of or within negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	12855558	MGI
acts upstream of or within negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15292044	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8663032	MGI
acts upstream of or within negative regulation of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	17267035	MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	10200548	MGI
acts upstream of or within negative regulation of lymphocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within negative regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	9241272	MGI
acts upstream of or within negative regulation of motor neuron apoptotic process	IDA IDA: Inferred from direct assay	7472523	MGI
acts upstream of or within negative regulation of myeloid cell apoptotic process	IDA IDA: Inferred from direct assay	9202146	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	8625820	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9153592	MGI
acts upstream of or within negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	9008714	MGI
acts upstream of or within negative regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	10193316	MGI
acts upstream of or within negative regulation of retinal cell programmed cell death	IMP IMP: Inferred from mutant phenotype	10321489	MGI
acts upstream of neuron apoptotic process	IDA IDA: Inferred from direct assay	8625820	MGI
acts upstream of or within neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10762311	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	9153592	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	7546744	MGI
acts upstream of neuron maturation	IMP IMP: Inferred from mutant phenotype	9547242	MGI
acts upstream of or within oocyte development	IMP IMP: Inferred from mutant phenotype	7628407	MGI
acts upstream of or within organ growth	IMP IMP: Inferred from mutant phenotype	7812968	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	10193316	MGI
acts upstream of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	10193316	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	7628407	MGI
acts upstream of or within peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	14660795	MGI
acts upstream of peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of or within peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	14660795	MGI
acts upstream of or within pigment granule organization	IMP IMP: Inferred from mutant phenotype	8758925	MGI
involved in pigmentation	IMP IMP: Inferred from mutant phenotype	8402909	MGI
acts upstream of or within positive regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	17382917	MGI
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11983915	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	8084613	MGI
acts upstream of or within positive regulation of developmental pigmentation	IGI IGI: Inferred from genetic interaction	9241272	MGI
acts upstream of or within positive regulation of melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	16427619	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	11709185	MGI
acts upstream of or within positive regulation of neuron maturation	IMP IMP: Inferred from mutant phenotype	9547242	MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation	IGI IGI: Inferred from genetic interaction	15613488	MGI
acts upstream of or within positive regulation of skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	11146504	MGI
acts upstream of or within positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	17382917	MGI
acts upstream of or within post-embryonic development	IGI IGI: Inferred from genetic interaction	9241272	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	7812968	MGI
acts upstream of or within protein dephosphorylation	IDA IDA: Inferred from direct assay	16717086	MGI
acts upstream of or within reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	9681465	MGI
acts upstream of or within regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	8918887	MGI
involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	22258505	MGI
acts upstream of or within regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	9681465	MGI
acts upstream of or within regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	10200548	MGI
acts upstream of or within regulation of cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	15292044	MGI
acts upstream of or within regulation of developmental pigmentation	IGI IGI: Inferred from genetic interaction	15818405	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	12855558	MGI
acts upstream of or within regulation of glycoprotein biosynthetic process	IMP IMP: Inferred from mutant phenotype	15292044	MGI
acts upstream of or within regulation of growth	IMP IMP: Inferred from mutant phenotype	7812968	MGI
involved in regulation of mitochondrial membrane permeability	IDA IDA: Inferred from direct assay	9843949	MGI
involved in regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	9843949	MGI
acts upstream of or within regulation of nitrogen utilization	IGI IGI: Inferred from genetic interaction	9241272	MGI
acts upstream of or within regulation of programmed cell death	IGI IGI: Inferred from genetic interaction	16672320	MGI
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	9950951	MGI
acts upstream of or within regulation of protein stability	IMP IMP: Inferred from mutant phenotype	14660795	MGI
involved in regulation of viral genome replication	IDA IDA: Inferred from direct assay	16950491	MGI
involved in release of cytochrome c from mitochondria	IDA IDA: Inferred from direct assay	9843949	MGI
acts upstream of or within renal system process	IMP IMP: Inferred from mutant phenotype	8760259	MGI
acts upstream of or within response to UV-B	IMP IMP: Inferred from mutant phenotype	10200548	MGI
acts upstream of or within response to acid chemical	IDA IDA: Inferred from direct assay	7675327	MGI
acts upstream of or within response to cytokine	IMP IMP: Inferred from mutant phenotype	12855558	MGI
acts upstream of or within response to gamma radiation	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within response to glucocorticoid	IDA IDA: Inferred from direct assay	8313913	MGI
acts upstream of or within response to glucocorticoid	IMP IMP: Inferred from mutant phenotype	8372353	MGI
acts upstream of or within response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	12855558	MGI
acts upstream of or within response to ischemia	IMP IMP: Inferred from mutant phenotype	10488913	MGI
acts upstream of or within response to oxidative stress	IMP IMP: Inferred from mutant phenotype	12855558	MGI
acts upstream of or within response to steroid hormone	IMP IMP: Inferred from mutant phenotype	8170972	MGI
acts upstream of or within response to toxic substance	IMP IMP: Inferred from mutant phenotype	10602483	MGI
acts upstream of or within response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	9098922	MGI
acts upstream of retinal cell programmed cell death	IMP IMP: Inferred from mutant phenotype	10321489	MGI
acts upstream of skeletal muscle fiber development	IMP IMP: Inferred from mutant phenotype	11146504	MGI
acts upstream of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	17382917	MGI
acts upstream of or within spleen development	IGI IGI: Inferred from genetic interaction	15818405	MGI
acts upstream of or within spleen development	IMP IMP: Inferred from mutant phenotype	15818405	MGI
acts upstream of or within stem cell development	IMP IMP: Inferred from mutant phenotype	8623928	MGI
acts upstream of or within thymus development	IGI IGI: Inferred from genetic interaction	15818405	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	9241272	MGI
acts upstream of or within ureteric bud development	IMP IMP: Inferred from mutant phenotype	8623928	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	36812915	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	7563251	MGI
located in cytosol	IDA IDA: Inferred from direct assay	8030757	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	8030757	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15613488	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	9008714	MGI
located in membrane	IDA IDA: Inferred from direct assay	8030757	MGI
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	11980919	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	7945396	MGI
located in myelin sheath	IDA IDA: Inferred from direct assay	7953633	MGI
located in nuclear membrane	IDA IDA: Inferred from direct assay	8030757	MGI
located in nucleus	IDA IDA: Inferred from direct assay	7945396	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bcl2 Protein Structure

bcl-2

0
100
200
236 a.a.

Protein Preferred Names

Protein Names

apoptosis regulator Bcl-2

Recombinant Bcl2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72101	BCL2 Protein, Mouse (His)	P10417-1 (G5-P205)	≥95%

Related Agents

Approval

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15531	Venetoclax		99.95%	Yes
HY-B0011	Docetaxel		99.94%	Unkown
HY-B0318	Metronidazole		99.92%	Yes
HY-13407	Gossypol	Antagonist	99.67%	Yes
HY-17510	Gossypol (acetic acid)	Inhibitor	99.75%	Yes
HY-B0011A	Docetaxel Trihydrate		99.92%	Unkown
HY-B0766	Bicyclol		99.91%	Unkown
HY-118874	Oblimersen		/	Unkown
HY-B0318A	Metronidazole hydrochloride		/	Unkown
HY-B0011R	Docetaxel (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105930	Lobaplatin		≥98.0%	Phase 4
HY-10087	Navitoclax	Inhibitor	99.97%	Phase 3
HY-10969	Obatoclax Mesylate		99.85%	Phase 3
HY-N0867	13-Oxyingenol-13-dodecanoate		99.37%	Phase 3
HY-10969A	Obatoclax		≥99.0%	Phase 3
HY-50868	Bafetinib		99.77%	Phase 2
HY-129179	Lisaftoclax	Inhibitor	99.28%	Phase 2
HY-109185	Pelcitoclax		99.70%	Phase 2
HY-15464A	(R)-(-)-Gossypol acetic acid		98.93%	Phase 2
HY-15464	(R)-(-)-Gossypol		98.82%	Phase 2
HY-138697	S65487		99.91%	Phase 2
HY-138697B	S65487 hydrochloride		99.67%	Phase 2
HY-123823	Nitroaspirin		/	Phase 2
HY-15464D	(S)-Gossypol (acetic acid)	Inhibitor	98.39%	Phase 2
HY-138697A	S65487 sulfate		98.08%	Phase 2
HY-13559	Atiprimod		/	Phase 2
HY-13659	KRN5500		/	Phase 2
HY-117288	S55746	Inhibitor	99.89%	Phase 1
HY-109184	Murizatoclax	Inhibitor	98.85%	Phase 1
HY-117288A	S55746 hydrochloride	Inhibitor	99.66%	Phase 1

Pre-clinical Phase

Bioactive Molecules (232)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50907	ABT-737		99.96%	Unkown
HY-107738	Guggulsterone		99.95%	Unkown
HY-130604	DT2216		99.97%	Unkown
HY-N2342	Procyanidin C1	Inducer	99.79%	Unkown
HY-N0292	Oleuropein		99.05%	Unkown
HY-N0674	Dehydrocorydaline		99.77%	Unkown
HY-126477	NNK		99.98%	Unkown
HY-N0087	Gambogic Acid		98.79%	Unkown
HY-N0361	Dihydrocapsaicin		99.93%	Unkown
HY-112416	AZD4320	Inhibitor	99.68%	Unkown
HY-18628	UMI-77	Inhibitor	99.66%	Unkown
HY-148026	Sonrotoclax	Inhibitor	99.61%	Unkown
HY-125877	PROTAC Mcl1 degrader-1	Inhibitor	98.13%	Unkown
HY-147081	AS 1411	Inhibitor	/	Unkown
HY-118119	CAY10526	Inhibitor	99.40%	Unkown
HY-126741	Azadirachtin		99.06%	Unkown
HY-N3584	Paris saponin VII		99.96%	Unkown
HY-125876	PROTAC Bcl2 degrader-1	Inhibitor	99.80%	Unkown
HY-124284	Hexamethylene bisacetamide		99.56%	Unkown
HY-15531S	Venetoclax-d8		99.76%	Unkown
HY-N0265	Asperosaponin VI	Inhibitor	98.91%	Unkown
HY-103243	TCPOBOP	Inhibitor	98.67%	Unkown
HY-N0674A	Dehydrocorydaline chloride		99.72%	Unkown
HY-N2897	Dihydrokaempferol		99.88%	Unkown
HY-12020	TW-37	Inhibitor	99.27%	Unkown
HY-N0440	Germacrone	Inhibitor	99.93%	Unkown
HY-33350	Clofilium tosylate		99.84%	Unkown
HY-139309	PROTAC Bcl-xL degrader-2	Inhibitor	98.16%	Unkown
HY-15191	Sabutoclax	Inhibitor	99.80%	Unkown
HY-N0674B	Dehydrocorydaline (hydroxyl)		99.52%	Unkown
HY-133557	XZ739		99.06%	Unkown
HY-138832	BM-1244	Inhibitor	99.85%	Unkown
HY-120882	BM-1197	Inhibitor	99.48%	Unkown
HY-12011	HA14-1	Inhibitor	≥98.0%	Unkown
HY-N3001	Isolinderalactone	Inhibitor	98.79%	Unkown
HY-N6850	Calenduloside E		99.07%	Unkown
HY-129700	MCL-1/BCL-2-IN-2	Inhibitor	99.12%	Unkown
HY-16014	A-385358	Inhibitor	98.19%	Unkown
HY-N1440	Koumine	Activator	99.97%	Unkown
HY-P1889	Bim BH3, Peptide IV		99.35%	Unkown
HY-129681	MCL-1/BCL-2-IN-1	Inhibitor	99.86%	Unkown
HY-10087S	Navitoclax-d8	Inhibitor	99.71%	Unkown
HY-157176	BAX-IN-1	Inhibitor	≥98.0%	Unkown
HY-161100	BDM19	Inducer	98.09%	Unkown
HY-N7930	Crenulatin		≥99.0%	Unkown
HY-142209	ABBV-167	Inhibitor	97.33%	Unkown
HY-100383	BH3I-1		≥98.0%	Unkown
HY-132307	Mcl-1 inhibitor 6		98.40%	Unkown
HY-119931	2-Hydroxychalcone		98.80%	Unkown
HY-156278	FB49	Inhibitor	99.76%	Unkown
HY-N1157	Thevetiaflavone		≥98.0%	Unkown
HY-N6690	Destruxin B		99.86%	Unkown
HY-113471A	(S)-(-)-Perillic acid		≥95.0%	Unkown
HY-118874A	Oblimersen sodium	Inhibitor	98.09%	Unkown
HY-161254	ATPase-IN-3		99.89%	Unkown
HY-169925	BM-962	Inhibitor	99.10%	Unkown
HY-B0011S	Docetaxel-d9		≥98.0%	Unkown
HY-N4238	Dehydrocorydaline nitrate		99.90%	Unkown
HY-P1527	Bim BH3		99.80%	Unkown
HY-RS01415	BCL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-109617	4-(4-Fluorophenyl)benzoic acid		99.01%	Unkown
HY-111329	JGB1741		99.05%	Unkown
HY-119833	Rubone	Modulator	99.1%	Unkown
HY-129179B	(Rac)-Lisaftoclax	Inhibitor	98.22%	Unkown
HY-13408	(+)-Apogossypol	Inhibitor	/	Unkown
HY-160921	Capeserod	Agonist	98.66%	Unkown
HY-161276	BFC1108	Inducer	98.11%	Unkown
HY-161410	WH244	Degrader	/	Unkown
HY-N0307	Ciwujianoside B	Inhibitor	99.00%	Unkown
HY-N2416	Taccalonolide A		99.29%	Unkown
HY-P2343	BH3 hydrochloride	Activator	98.02%	Unkown
HY-RS01431	BCL2L13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-15191B	(S)-Sabutoclax	Inhibitor	98.03%	Unkown
HY-114310	VDR agonist 1		/	Unkown
HY-128360	dMCL1-2	Inhibitor	/	Unkown
HY-131247	Bcl-2-IN-2	Inhibitor	/	Unkown
HY-135273	A-1211212		/	Unkown
HY-155188	NWP-0476	Inhibitor	/	Unkown
HY-19551	Apogossypolone		/	Unkown
HY-100762	Mcl1-IN-11	Inhibitor	/	Unkown
HY-100763	Mcl1-IN-12	Inhibitor	/	Unkown
HY-146097	RMS5		/	Unkown
HY-149918	Antiproliferative agent-23		/	Unkown
HY-156620	Lacutoclax	Inhibitor	/	Unkown
HY-18106	BM 957	Inhibitor	/	Unkown
HY-10087A1	Navitoclax dihydrochloride	Inhibitor	/	Unkown
HY-101083	BDA-366	Antagonist	/	Unkown
HY-101999	EM20-25		/	Unkown
HY-115974	GRPR antagonist-1		/	Unkown
HY-118925	Holothurin A	Inhibitor	/	Unkown
HY-121934	BH3I-2'		/	Unkown
HY-123034	CDKI-83		/	Unkown
HY-123244	YC137		/	Unkown
HY-124122	BPTQ		/	Unkown
HY-125191	BRD1991	Inhibitor	/	Unkown
HY-127130	Spicamycin		/	Unkown
HY-129701	MCL-1/BCL-2-IN-3	Inhibitor	99.22%	Unkown
HY-129702	MCL-1/BCL-2-IN-4	Inhibitor	/	Unkown
HY-131188	PROTAC Bcl-xL degrader-1	Inhibitor	/	Unkown
HY-131405	β-Eleostearic acid	Inhibitor	/	Unkown
HY-133772	Venetoclax N-oxide		/	Unkown
HY-13846	BM-1074		/	Unkown
HY-143235	BRD4 Inhibitor-15		/	Unkown
HY-143872	Bcl-2-IN-4	Inhibitor	/	Unkown
HY-143873	Bcl-2-IN-5	Inhibitor	/	Unkown
HY-144428	Bcl-2/Mcl-1-IN-2	Inhibitor	/	Unkown
HY-144430	Bcl-2/Mcl-1-IN-1	Inhibitor	/	Unkown
HY-144431	Bcl-2/Mcl-1-IN-3	Inhibitor	/	Unkown
HY-144778	IDO1/TDO-IN-1		/	Unkown
HY-144791	Bcl-2-IN-6		/	Unkown
HY-144792	Bcl-2-IN-7		/	Unkown
HY-145288	Antitumor agent-36		/	Unkown
HY-145289	Antitumor agent-37		/	Unkown
HY-146095	p53 Activator 2		/	Unkown
HY-146253	CDK1/2/4-IN-1		/	Unkown
HY-146444	Anticancer agent 56		/	Unkown
HY-146471	EGFR-IN-51		/	Unkown
HY-146472	EGFR-IN-52		/	Unkown
HY-146817	Tubulin polymerization-IN-11		/	Unkown
HY-147504	Anticancer agent 63		/	Unkown
HY-147826	EGFR-IN-60		/	Unkown
HY-147906	Anticancer agent 71		/	Unkown
HY-147928	Apoptotic agent-2		/	Unkown
HY-147929	Apoptotic agent-3		/	Unkown
HY-149009	Bcl-2-IN-9		/	Unkown
HY-149024	VEGFR-2-IN-23		/	Unkown
HY-149436	CDK2/Bcl2-IN-1	Inhibitor	/	Unkown
HY-149622	Bcl-2-IN-12	Inhibitor	/	Unkown
HY-149623	Bcl-2-IN-13	Inhibitor	/	Unkown
HY-149624	Bcl-2-IN-14	Inhibitor	/	Unkown
HY-149625	Bcl-2-IN-15	Inhibitor	/	Unkown
HY-149681	Beclin1-Bcl-2 interaction inhibitor 1	Inhibitor	/	Unkown
HY-150540	Bcl-2-IN-10		/	Unkown
HY-150596	CT1-3		/	Unkown
HY-151428	Antitumor agent-78		/	Unkown
HY-151429	Antitumor agent-77		/	Unkown
HY-151443	HDAC-IN-47	Inhibitor	/	Unkown
HY-153494	Rosomidnar	Inhibitor	/	Unkown
HY-153494A	Rosomidnar sodium	Inhibitor	/	Unkown
HY-153953	Bcl-2-IN-11	Inhibitor	/	Unkown
HY-155242	VEGFR-2-IN-36		/	Unkown
HY-156096	HDAC3-IN-2		/	Unkown
HY-156877	Bcl-2-IN-16		/	Unkown
HY-157343	GD3 Ganglioside		/	Unkown
HY-157343A	GD3 Ganglioside sodium		/	Unkown
HY-159513	Bcl-2/Mcl-1-IN-4	Inhibitor	/	Unkown
HY-159668	DL002		/	Unkown
HY-159817	Asaretoclax	Inhibitor	/	Unkown
HY-160108	Bcl-2-IN-17	Inhibitor	/	Unkown
HY-161415	BCL-xL/BCL-2 ligand 1		/	Unkown
HY-161577	BFC1103		/	Unkown
HY-161659	Apoptosis inducer 19		/	Unkown
HY-161732	GQN-B37-E	Inhibitor	/	Unkown
HY-161786	Bcl-2-IN-20		/	Unkown
HY-162148	HNPMI	Inhibitor	99.57%	Unkown
HY-162820	Bcl-2-IN-21	Inhibitor	/	Unkown
HY-162826	Apoptosis inducer 27	Inducer	/	Unkown
HY-162886	BSO-07	Activator	/	Unkown
HY-163077	Anticancer agent 175	Inducer	/	Unkown
HY-163308	Bcl-2-IN-18	Inhibitor	/	Unkown
HY-163309	Bcl-2-IN-19	Inhibitor	/	Unkown
HY-163435	Anticancer agent 201		/	Unkown
HY-163527	FGFR-IN-13	Inhibitor	/	Unkown
HY-163764	Bfl-1-IN-4		/	Unkown
HY-167825	Barakol		/	Unkown
HY-168171	ERK1/2 inhibitor 11		/	Unkown
HY-168623	EGFR-IN-134		/	Unkown
HY-168739	Topoisomerase I inhibitor 17		/	Unkown
HY-169083	Bcl-2-IN-22	Inhibitor	/	Unkown
HY-169096	DPP-21		/	Unkown
HY-169124	Apoptosis inducer 28		/	Unkown
HY-169265	BRD-K20733377	Inhibitor	/	Unkown
HY-169266	BRD-K56819078	Inhibitor	/	Unkown
HY-169267	BRD-K44839765	Inhibitor	/	Unkown
HY-169412	MAPK-IN-3		/	Unkown
HY-169431	VEGFR-2/AKT-IN-2		/	Unkown
HY-18628S	UMI-77-d4	Inhibitor	/	Unkown
HY-50907S	ABT-737-d8		99.11%	Unkown
HY-B0011AS	Docetaxel-d5 trihydrate		/	Unkown
HY-N0361S	Dihydrocapsaicin-d3		/	Unkown
HY-N10091	2,3-Dihydro-3α-methoxynimbolide		/	Unkown
HY-N1218	Stellasterol	Inhibitor	/	Unkown
HY-N1930	(-)-Hinesol	Inducer	/	Unkown
HY-N2741	Vitexin B-1	Inhibitor	/	Unkown
HY-N3828	epi-Eriocalyxin A		/	Unkown
HY-P10057	cpm-1285	Inducer	/	Unkown
HY-P10058	cpm-1285m		/	Unkown
HY-P1733	BMf-BH3		/	Unkown
HY-P1889A	Bim BH3, Peptide IV TFA		/	Unkown
HY-P5324	Bad BH3 (mouse)		/	Unkown
HY-P5325	Bid BH3 (80-99)		/	Unkown
HY-P5327	r8 Bid BH3		/	Unkown
HY-RS01416	Bcl2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01417	BCL2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01418	BCL2A1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01419	Bcl2a1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS01420	Bcl2a1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01421	BCL2L1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01422	Bcl2l1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01423	Bcl2l1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS01424	BCL2L10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01425	Bcl2l10 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01426	Bcl2l10 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01427	BCL2L11 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01428	Bcl2l11 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01429	Bcl2l11 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS01430	BCL2L12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01432	BCL2L14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01433	BCL2L15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01434	BCL2L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01435	Bcl2l2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01436	Bcl2l2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-101083A	(Rac)-BDA-366	Inhibitor	/	Unkown
HY-111244	DCB-3503		/	Unkown
HY-115529	(-)BI97D6	Inducer	/	Unkown
HY-116204	SKLB70326		/	Unkown
HY-116532	YCW-E11	Inhibitor	/	Unkown
HY-117136	AN-7		/	Unkown
HY-12011A	(Rac)-HA14-1	Inhibitor	/	Unkown
HY-122047	SW063058		/	Unkown
HY-123020	CYD-2-88		/	Unkown
HY-123715	Anticancer agent 255		/	Unkown
HY-127057	Lambertianic acid		/	Unkown
HY-136714	Bcl-2-IN-3	Inhibitor	/	Unkown
HY-164468	Ch282-5	Inhibitor	/	Unkown
HY-167881	MLS-0053105	Inhibitor	/	Unkown
HY-171031	TFGF-18		/	Unkown
HY-B1559	Allethrin	Inducer	98.04%	Unkown
HY-N15136	Isomorellinol	Inducer	/	Unkown
HY-N8579	Eugenyl benzoate		/	Unkown
HY-P10336	Serpinin	Agonist	/	Unkown
HY-W751400	Solasodine hydrochloride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcl2	NCBI	NCBI:596

Name
Email *

	Sorry, but the email address you supplied was invalid.