1. Gene
  2. Pc - pyruvate carboxylase Gene

Pc - pyruvate carboxylase Gene

Rattus norvegicus

Also known as Pcx

Gene ID: 25104 | Gene type: protein coding

About Pc

Summary

Enables ATP binding activity; biotin binding activity; and pyruvate carboxylase activity. Involved in carboxylic acid metabolic process; gluconeogenesis; and positive regulation of phospholipid biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Apr 2022]

Pc Products(2)

mRNA Protein Name
NM_012744.3 NP_036876.2 pyruvate carboxylase, mitochondrial precursor
NM_012744.3 NP_036876.2 pyruvate carboxylase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
5773282 RGD
enables biotin binding IDA
IDA: Inferred from direct assay
12949377 RGD
enables biotin binding IMP
IMP: Inferred from mutant phenotype
12949377 RGD
enables carboxylic acid binding IDA
IDA: Inferred from direct assay
15507531 RGD
enables pyruvate carboxylase activity IDA
IDA: Inferred from direct assay
4353083 RGD
enables pyruvate carboxylase activity IMP
IMP: Inferred from mutant phenotype
12949377 RGD
Biological Process GO Annotation Evidence Reference Source
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
4353083 RGD
involved in oxaloacetate metabolic process IDA
IDA: Inferred from direct assay
5773282 RGD
involved in positive regulation of phospholipid biosynthetic process IMP
IMP: Inferred from mutant phenotype
23357280 RGD
involved in pyruvate metabolic process IDA
IDA: Inferred from direct assay
5773282 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pyruvate carboxylase, mitochondrial

PCB

pyruvic carboxylase

Orthologs Information

Species Symbol Source ID
Homo sapiens Pc NCBI NCBI:5091
Macaca fascicularis Pc NCBI NCBI:102146568
Mus musculus Pc NCBI NCBI:18517
Susscrofa domestica Pc NCBI
Macaca mulatta Pc NCBI NCBI:713103