1. Gene
  2. C5 - complement C5 Gene

C5 - complement C5 Gene

Rattus norvegicus

Also known as Hc; C5a; RGD1561905

Gene ID: 362119 | Gene type: protein coding

About C5

Summary

Enables C5a anaphylatoxin chemotactic receptor binding activity. Involved in several processes, including glucose homeostasis; leukocyte migration involved in inflammatory response; and negative regulation of Catecholamine secretion. Located in extracellular space. Used to study adult respiratory distress syndrome; asthma; and neutropenia. Biomarker of brain edema. Human ortholog(s) of this gene implicated in several diseases, including Complement Component 5 deficiency; liver cirrhosis; neutropenia; paroxysmal nocturnal hemoglobinuria; and pneumonia. Orthologous to human C5 (complement C5). [provided by Alliance of Genome Resources, Apr 2022]

C5 Products(1)

mRNA Protein Name
NM_053020.1 NP_444179.1 complement C5 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables C5a anaphylatoxin chemotactic receptor binding IDA
IDA: Inferred from direct assay
7987212 RGD
Biological Process GO Annotation Evidence Reference Source
involved in chemotaxis IDA
IDA: Inferred from direct assay
10410979 RGD
involved in intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
10532591 RGD
involved in leukocyte migration involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
10843715 RGD
involved in negative regulation of dopamine secretion IDA
IDA: Inferred from direct assay
18648551 RGD
involved in negative regulation of norepinephrine secretion IDA
IDA: Inferred from direct assay
18648551 RGD
involved in positive regulation of chemotaxis IDA
IDA: Inferred from direct assay
7987212 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
9272704 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
9246574 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement C5

anaphylatoxin

complement component 5

Orthologs Information

Species Symbol Source ID
Homo sapiens C5 NCBI NCBI:727
Macaca fascicularis C5 NCBI NCBI:102125658
Mus musculus C5 NCBI
Susscrofa domestica C5 NCBI
Macaca mulatta C5 NCBI NCBI:700467