C5 - complement C5 Gene

Homo sapiens

Also known as C5D; C5a; C5b; ECLZB; CPAMD4

Gene ID: 727 | Gene type: protein coding

About C5

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:120,952,335-121,074,865 (from NCBI)

This gene has 13 transcripts (splice variants), 196 orthologues, 8 paralogues and is associated with 3 phenotypes. Biased expression in liver (RPKM 85.9) and lung (RPKM 3.7).

Summary

This gene encodes a component of the Complement System, a part of the innate immune system that plays an important role in inflammation, host homeostasis, and host defense against pathogens. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the C5 alpha chain, C5 beta chain, C5a anaphylatoxin and C5b. The C5 protein is comprised of the C5 alpha and beta chains, which are linked by a disulfide bridge. Cleavage of the alpha chain by a convertase Enzyme results in the formation of the C5a anaphylatoxin, which possesses potent spasmogenic and chemotactic activity, and the C5b macromolecular cleavage product, a subunit of the membrane attack complex (MAC). Mutations in this gene cause Complement Component 5 deficiency, a disease characterized by recurrent Bacterial infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]

C5 Products(3)

mRNA	Protein	Name
NM_001317163.2	NP_001304092.1	complement C5 isoform 2
NM_001317164.2	NP_001304093.1	complement C5 isoform 3 precursor
NM_001735.3	NP_001726.2	complement C5 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19528535	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of macrophage chemotaxis	IDA IDA: Inferred from direct assay	14566334	GOA
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	14566334	GOA
involved in positive regulation of vascular endothelial growth factor production	IDA IDA: Inferred from direct assay	14566334	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of membrane attack complex	IDA IDA: Inferred from direct assay	22832194	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C5 Protein Structure

A2M_N

A2M_N_2

ANATO

A2M

A2M_comp

A2M_recep

NTR

0
300
600
900
1200
1500
1676 a.a.

Protein Preferred Names

Protein Names

complement C5

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4

C5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	C5	P01031	PGRMC2	Homo sapiens	O15173	Y2H Array	32296183
Intra	C5	P01031	PGRMC2	Homo sapiens	O15173	Y2H Prey Pooling	32296183
Intra	C5	P01031	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	C5	P01031	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	C5	P01031	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	C5	P01031	POU6F2	Homo sapiens	P78424	Validated Y2H	32296183
Intra	C5	P01031	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	C5	P01031	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	C5	P01031	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	C5	P01031	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	C5	P01031	KIR3DL3	Homo sapiens	Q8N743	Validated Y2H	32296183
Intra	C5	P01031	KIR3DL3	Homo sapiens	Q8N743	Y2H Array	32296183
Intra	C5	P01031	KIR3DL3	Homo sapiens	Q8N743	Y2H Prey Pooling	32296183
Intra	C5	P01031	SSMEM1	Homo sapiens	Q8WWF3	Y2H Array	32296183
Intra	C5	P01031	SSMEM1	Homo sapiens	Q8WWF3	Validated Y2H	32296183
Intra	C5	P01031	SSMEM1	Homo sapiens	Q8WWF3	Y2H Prey Pooling	32296183
Intra	C5	P01031	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	C5	P01031	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	C5	P01031	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	C5	P01031	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	C5	P01031	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	C5	P01031	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	C5	P01031	CFHR1	Homo sapiens	Q03591	Anti Bait CoIP	19528535
Intra	C5	P01031	CFHR1	Homo sapiens	Q03591	SPR	19528535
Intra	C5	P01031	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	C5	P01031	MMGT1	Homo sapiens	Q8N4V1	Validated Y2H	32296183
Intra	C5	P01031	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	C5	P01031	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	25416956
Intra	C5	P01031	ANKS6	Homo sapiens	Q68DC2	Y2H Array	32296183
Intra	C5	P01031	ANKS6	Homo sapiens	Q68DC2	Y2H Prey Pooling	32296183
Intra	C5	P01031	ANKS6	Homo sapiens	Q68DC2	Validated Y2H	32296183
Cross	C5	P01031	vco3_najka	Naja kaouthia	Q91132	X-Ray Diffraction	21217642
Intra	C5	P01031	KEL	Homo sapiens	P23276	Y2H Array	32296183
Intra	C5	P01031	KEL	Homo sapiens	P23276	Y2H Prey Pooling	32296183
Intra	C5	P01031	KEL	Homo sapiens	P23276	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant C5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7864	Complement C5/C5a Protein, Human	P01031 (T678-R751)	≥95%
HY-P700862	Complement C5 Protein, Human (HEK293, His)	P01031 (Q19-C1676)	≥95%
HY-P700959	Complement C5/C5a Protein, Human (His)	P01031 (T678-R751)	≥95%

Related Diseases

Diseases

Alias

Complement Component 5 Deficiency

C5 Deficiency

C5D

Eculizumab, Poor Response To

Leiner Disease

Erythroderma Desquamativum

Complement Component 5 Deficiency

Immunodeficiency Due To A Late Component Of Complement Deficiency

Immunodeficiency Due To C5 To C9 Component Complement Deficiency

Terminal Complement Pathway Deficiency

Complement Deficiency

Complement Deficiency Disease

Hereditary Complement Deficiency Diseases

Acute Poststreptococcal Glomerulonephritis

Post-Streptococcal Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Hemoglobinuria

Hemolytic-Uremic Syndrome

Hemolytic Uremic Syndrome	Haemolytic-Uraemic Syndrome
Hus	Acute Renal Failure, Thrombocytopenia, And Microangiopathic Hemolytic Anemia Associated With Distorted Erythrocytes
Typical Haemolytic Uraemic Syndrome	Gasser Syndrome
Hus - [Haemolytic Uraemic Syndrome]

Meningoencephalitis

Acquired Toxoplasmal Meningoencephalitis	Meningoencephalitis Due To Acquired Toxoplasmosis
Meningoencephalitis Due To Toxoplasmosis	Toxoplasma Meningoencephalitis

Hellp Syndrome

Hemolysis, Elevated Liver Enzymes, Lowered Platelets	Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy
Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome	Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet]
Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Macular Degeneration, Age-Related, 1

Macular Degeneration	Age-Related Macular Degeneration
Macular Degeneration, Age-Related	Age Related Macular Degeneration
Age Related Macular Degeneration 1	ARMD1
Senile Macular Degeneration	Maculopathy, Age-Related, 1
Macular Degeneration, Age-Related, Reduced Risk Of	Age Related Maculopathy 1
Age Related Maculopathies	Age Related Maculopathy
Senile Macular Retinal Degeneration	Macular Degeneration Of Retina
Age-Related Maculopathy	Amd
Armd	Age-Related Maculopathy, Susceptibility To
Maculopathy Age-Related	Macular Degeneration, Age-Related, 1, Susceptibility To
Maculopathy, Age-Related	Macular Degeneration, Age-Related, Type 1
Macular Degeneration, Age-Related, 2

Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis	Dense Deposit Disease
Membranoproliferative Glomerulonephritis Type 2	Primary Membranoproliferative Glomerulonephritis
Mesangiocapillary Glomerulonephritis, Type Ii	Glomerulonephritis, Membranoproliferative
Chronic Glomerulonephritis, Lobular	Lobular Glomerulonephritis
Ddd	Glomerulonephritis Membranoproliferative Type 2
Mpgn 2	Membranoproliferative Glomerulonephritis Type Ii
Mesangiocapillary Glomerulonephritis Type 2	Mpgn
Primary Mpgn	Glomerulonephritis Membranoproliferative
Membranoproliferative Glomerulonephritis, Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14541	Olanzapine		99.83%	Yes
HY-17627	Avacopan	Inhibitor	99.75%	Yes
HY-147080	Avacincaptad pegol sodium	Inhibitor	98.53%	Unkown
HY-11100	Asenapine maleate	Antagonist	99.95%	Unkown
HY-B1213	Trimipramine maleate		99.82%	Unkown
HY-P3502	Zilucoplan	Inhibitor	95.33%	Unkown
HY-16567	Asenapine hydrochloride	Antagonist	99.95%	Unkown
HY-148457	Avacincaptad pegol	Inhibitor	/	Unkown
HY-14541R	Olanzapine (Standard)		/	Unkown
HY-B1213A	Trimipramine		/	Unkown

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99394	Talquetamab		98.52%	Unkown
HY-P9914	Eculizumab	Inhibitor	97.81%	Unkown
HY-P99365	Ravulizumab	Inhibitor	95.00%	Unkown
HY-P99965	Crovalimab	Inhibitor	98.61%	Unkown
HY-P99786	Pozelimab	Inhibitor	99.45%	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-E70206	CpG Methyltransferase		/	Phase 4
HY-145720	Cemdisiran	Inhibitor	/	Phase 3
HY-101324A	MK-212 monohydrochloride	Agonist	99.62%	Phase 3
HY-101324	MK-212	Agonist	/	Phase 3
HY-106178	PMX-53	Antagonist	99.98%	Phase 2
HY-111200	Vabicaserin hydrochloride	Agonist	99.92%	Phase 2
HY-101755	Tedatioxetine hydrobromide	Antagonist	99.83%	Phase 2
HY-19283	DU125530	Antagonist	/	Phase 2
HY-123044	Tedatioxetine	Antagonist	/	Phase 1

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99520	Vilobelimab	Inhibitor	99.27%	Phase 3
HY-P99638	Gefurulimab	Inhibitor	97.88%	Phase 3
HY-P99886	Pexelizumab	Inhibitor	/	Phase 3
HY-P99322	Tesidolumab	Inhibitor	97.01%	Phase 2
HY-P99450	Avdoralimab	Inhibitor	95.16%	Phase 2
HY-P99767	Olendalizumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (370)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0390S1	L-Glutamine-13C5		99.93%	Unkown
HY-149652	IRF5-IN-1		99.91%	Unkown
HY-128729	DNA2 inhibitor C5	Inhibitor	98.51%	Unkown
HY-138161	JR14a	Antagonist	99.59%	Unkown
HY-110136A	PMX 205 Trifluoroacetate	Antagonist	99.50%	Unkown
HY-D1612	BODIPY FL C5-Ceramide		99.65%	Unkown
HY-103124	DOI hydrochloride	Agonist	99.61%	Unkown
HY-148141	JPE-1375	Antagonist	99.94%	Unkown
HY-W008820	Glutaric acid		98.44%	Unkown
HY-125876	PROTAC Bcl2 degrader-1	Inhibitor	99.80%	Unkown
HY-N0092S2	Inosine-13C5		99.90%	Unkown
HY-W013636S	2-Ketoglutaric acid-13C5		98.6%	Unkown
HY-128342	Complement C5-IN-1	Inhibitor	99.14%	Unkown
HY-16992A	W-54011		≥98.0%	Unkown
HY-N0717S6	L-Valine-13C5		99.6%	Unkown
HY-Y0252S	L-Proline-13C5		99.00%	Unkown
HY-14608S3	L-Glutamic acid-13C5,15N		≥98.0%	Unkown
HY-N0326S5	L-Methionine-13C5		98.40%	Unkown
HY-145237	BM213	Agonist	99.81%	Unkown
HY-B0228S1	Adenosine-13C5		99.35%	Unkown
HY-126523	N3-C5-NHS ester		≥98.0%	Unkown
HY-W004710	NH2-C5-NH-Boc		99.88%	Unkown
HY-122725B	Lenalidomide-C5-NH2 hydrochloride		98.44%	Unkown
HY-130798	(S,R,S)-AHPC-amido-C5-acid		99.58%	Unkown
HY-B0445S	NAD+-13C5 ammonium		98.89%	Unkown
HY-132248	C5 Lenalidomide	Inhibitor	99.62%	Unkown
HY-157080	Dibromomaleimide-C5-COOH		99.30%	Unkown
HY-W008820S1	Glutaric acid-d4		≥99.0%	Unkown
HY-14608S5	L-Glutamic acid-13C5		≥98.0%	Unkown
HY-151667	Biotin-C5-Azide		≥98.0%	Unkown
HY-110060	NDT 9513727	Antagonist	99.35%	Unkown
HY-130703	5-Dehydroepisterol	Inhibitor	92.36%	Unkown
HY-141840	GLP-1R modulator C5	Modulator	99.60%	Unkown
HY-148671	(S,R,S)-AHPC-amido-C7-acid		98.28%	Unkown
HY-D1610	BODIPY FL C5		99.68%	Unkown
HY-N0390S6	L-Glutamine-13C5,15N2		≥98.0%	Unkown
HY-P0014S1	Liraglutide-13C5,15N TFA		98.19%	Unkown
HY-W006057AS16	Sodium 3-methyl-2-oxobutanoate-13C5		99.00%	Unkown
HY-131889	Thalidomide-O-C5-acid	Inducer	95.82%	Unkown
HY-N0717S1	L-Valine-13C5,15N		≥98.0%	Unkown
HY-R00540A	hsa-miR-30c-5p agomir		96.15%	Unkown
HY-RI00540	hsa-miR-30c-5p inhibitor		96.52%	Unkown
HY-W010184S	4,6-Dioxoheptanoic acid-13C5		99.8%	Unkown
HY-Y0252S4	L-Proline-13C5,15N		99.60%	Unkown
HY-Y0520S	Itaconic acid-13C5		≥97.00%	Unkown
HY-153785	NH2-C6-ARC186 sodium	Inhibitor	92.50%	Unkown
HY-B1511S	Cyclic AMP-13C5		97.45%	Unkown
HY-129608	Lenalidomide-acetylene-C5-COOH		99.26%	Unkown
HY-130849	(S,R,S)-AHPC-Me-C5-COOH		96.87%	Unkown
HY-136237	Thalidomide-NH-C5-NH2 hydrochloride	Inducer	99.28%	Unkown
HY-145720A	Cemdisiran sodium		96.02%	Unkown
HY-137905	Pomalidomide-amido-C5-PEG2-C6-chlorine		99.69%	Unkown
HY-138848A	Thalidomide-4-O-C5-NH2 hydrochloride	Inducer	96.87%	Unkown
HY-153098	ARC186	Inhibitor	94.13%	Unkown
HY-B1449S10	Uridine-13C5		99.68%	Unkown
HY-N0326S6	L-Methionine-13C5,15N		99.20%	Unkown
HY-R00540	hsa-miR-30c-5p mimic		94.48%	Unkown
HY-15543A	CP-809101 hydrochloride	Agonist	99.37%	Unkown
HY-113038AS	α-Hydroxyglutaric acid-13C5 disodium		99.80%	Unkown
HY-128848	Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH		95.02%	Unkown
HY-132141	5-PA-dUTP		≥98.0%	Unkown
HY-153098A	ARC186 sodium	Inhibitor	94.13%	Unkown
HY-164088	DBM-C5-VC-PAB-MMAE	Inhibitor	/	Unkown
HY-R00007	hsa-let-7c-5p mimic		91.21%	Unkown
HY-R01569	hsa-miR-518c-5p mimic		91.42%	Unkown
HY-RI00007A	hsa-let-7c-5p antagomir		93.03%	Unkown
HY-RI00334	hsa-miR-181c-5p inhibitor		97.20%	Unkown
HY-RI00540A	hsa-miR-30c-5p antagomir		95.34%	Unkown
HY-W018772S15	D-Ribose(mixture of isomers)-13C5		99.90%	Unkown
HY-W096148	Biotin-C4-amide-C5-NH2		≥97.0%	Unkown
HY-P1033S1	[Pyr1]-Apelin-13, Pro(13C5,15N) TFA		99.85%	Unkown
HY-W779017	Thymidine-13C5	Inhibitor	99.90%	Unkown
HY-101343	RS 39604	Antagonist	≥98.0%	Unkown
HY-108372	Boc-C5-O-C5-O-C6-Cl		/	Unkown
HY-110136	PMX 205	Antagonist	/	Unkown
HY-112199	CP-447697	Antagonist	99.70%	Unkown
HY-131455A	Biotin-C1-PEG3-C3-amido-C5-Gly-Arg-Gly-N3 TFA		≥98.0%	Unkown
HY-132856	Lenalidomide-C5-amido-Boc		95.10%	Unkown
HY-139336	Pomalidomide-C5-azide		97.46%	Unkown
HY-14608S4	L-Glutamic acid-13C5,15N,d5		≥99.0%	Unkown
HY-150918S	5-Methyl-1H-pyrazole-3-propanoic acid-13C5		/	Unkown
HY-155672	JPC0323	Modulator	99.5%	Unkown
HY-16637S3	Folic acid-13C5		≥95.0%	Unkown
HY-D1613	BODIPY FL C5-HPC		99.43%	Unkown
HY-N0322S3	Cholesterol-13C5	Agonist	≥98.0%	Unkown
HY-N0390S3	L-Glutamine-13C5,15N2,d5		99.91%	Unkown
HY-P4820A	SYNV-cyclo(CGGYF) TFA	Inhibitor	97.08%	Unkown
HY-P5506	C5a Receptor agonist, W5Cha	Agonist	99.50%	Unkown
HY-R00007A	hsa-let-7c-5p agomir		/	Unkown
HY-W017018S2	L-Ornithine-1,2,3,4,5-13C5 hydrochloride		99.5%	Unkown
HY-W017387S2	Sodium α-ketoisocaproic acid-13C5		99.3%	Unkown
HY-113046S	5-Methyltetrahydrofolic acid-13C5		≥98.0%	Unkown
HY-135916	Biotin-C5-amino-C5-amino		/	Unkown
HY-B0445S1	NAD+-13C5		98.90%	Unkown
HY-N0091S	Hypoxanthine-13C5,15N4		≥99.0%	Unkown
HY-N0091S2	Hypoxanthine-13C5		≥98.0%	Unkown
HY-P10639	C5aR2 agonist P32	Agonist	99.82%	Unkown
HY-W028210	O-Phthalimide-C5-acid		≥98.0%	Unkown
HY-122725A	Lenalidomide-C5-NH2 TFA		98.94%	Unkown
HY-141423	Thalidomide-O-amide-C5-NH2	Inducer	/	Unkown
HY-141423A	Thalidomide-O-amide-C5-NH2 TFA	Inducer	/	Unkown
HY-Y1055S4	Guanine-13C5	Chemical	/	Unkown
HY-136055	(S,R,S)-AHPC-C5-COOH	Inhibitor	98.81%	Unkown
HY-103120	Org37684	Antagonist	/	Unkown
HY-10984S3	Pomalidomide-15N,13C5	Inducer	/	Unkown
HY-112675S	4-Octyl itaconate-13C5-1		/	Unkown
HY-113062S	20α-Dihydroprogesterone-13C5		/	Unkown
HY-113420S2	11-Dehydro-thromboxane B2-13C5		/	Unkown
HY-117811	(R,R)-MK 287		/	Unkown
HY-117971	BVT173187		/	Unkown
HY-120498	RS-64459-193	Agonist	/	Unkown
HY-124117	LY 278584	Antagonist	/	Unkown
HY-12956S2	Dinoprost-13C5		/	Unkown
HY-130712	NH2-C2-amido-C2-Boc		/	Unkown
HY-130946	NH2-C5-PEG4-N3-L-Lysine-PEG3-N3		/	Unkown
HY-132939	2-(2,6-Dioxopiperidin-3-yl)phthalimidine-C5-Br	Chemical	/	Unkown
HY-134737	Boc-NH-PEG1-C5-OH		/	Unkown
HY-134986	Thalidomide-NH-C5-NH2	Inducer	/	Unkown
HY-136187	(S,R,S)-AHPC-C5-NH2		/	Unkown
HY-136187A	(S,R,S)-AHPC-C5-NH2 dihydrochloride		/	Unkown
HY-138098	Sartorypyrone B		/	Unkown
HY-138848	Thalidomide-4-O-C5-NH2	Inducer	/	Unkown
HY-138851	Thalidomide-NH-amido-C5-NH2	Inducer	/	Unkown
HY-138851A	Thalidomide-NH-amido-C5-NH2 hydrochloride	Inducer	/	Unkown
HY-139996	Pomalidomide-C5-Dovitinib		/	Unkown
HY-141062	N-Methyl-N'-(azido-PEG2-C5)-Cy5		/	Unkown
HY-141143	MC(C5)-Val-Cit		/	Unkown
HY-141593	Modified MMAF-C5-COOH		/	Unkown
HY-141902S	Fmoc-Glu(OtBu)-OH-13C5,15N		/	Unkown
HY-14291S2	Vildagliptin-13C5,15N		/	Unkown
HY-143340	LEB-03-145		/	Unkown
HY-144676	pan-HER-IN-1		/	Unkown
HY-147077	Triantennary GalNAc-1		/	Unkown
HY-147585	C5aR-IN-1		/	Unkown
HY-147586	C5aR-IN-2		/	Unkown
HY-147587	C5aR-IN-3		/	Unkown
HY-14781S2	Levomefolic acid-13C5		/	Unkown
HY-148326	Glu(OtBu)-Val-Cit-PAB-OH		/	Unkown
HY-148362	Pomalidomide-C6-O-C5-O-C4-COOH		98.55%	Unkown
HY-149751	Methylthiomcresol-C5-COOH		/	Unkown
HY-150632	SARS-CoV-2 nsp13-IN-6	Inhibitor	/	Unkown
HY-150660S	Ercalcidiol-13C5		/	Unkown
HY-150661S	3-epi-Calcifediol-13C5		/	Unkown
HY-150663S	Calcitriol-13C5		/	Unkown
HY-153464	CXCR4-IN-1	Inhibitor	/	Unkown
HY-15398S4	Vitamin D3-13C5		/	Unkown
HY-155186	SARS-CoV-2 3CLpro-IN-19	Inhibitor	/	Unkown
HY-155261	Pomalidomide-5-C5-NH2 hydrochloride		/	Unkown
HY-155506	NAMPT degrader-3	Degrader	/	Unkown
HY-157511	Thalidomide-O-C5-azide		/	Unkown
HY-157933	SF-C5-TPP		/	Unkown
HY-158627	JPC0323 Oleate		/	Unkown
HY-159570	XD2-149		/	Unkown
HY-159571	Thalidomide-NH-C5-azacyclohexane-N-Boc		/	Unkown
HY-159572	NH2-C5-Azacyclohexane-N-Boc		/	Unkown
HY-160077	Pomalidomide-CO-C5-azide		/	Unkown
HY-160241	Lenalidomide-C5-acid		96.36%	Unkown
HY-161132	Lenalidomide 4'-alkyl-C5-azide		/	Unkown
HY-161793	(S,R,S)-AHPC-NHCO-C-O-C5-N3		/	Unkown
HY-161939	7030B-C5	Inhibitor	/	Unkown
HY-163378	C5aR1 antagonist 1	Antagonist	/	Unkown
HY-163379	C5aR1 antagonist 2	Antagonist	/	Unkown
HY-163788	C5-CONH-C2-N-CH3		/	Unkown
HY-16384	L-156602	Antagonist	/	Unkown
HY-164084	DBCO-NHCO-C5-O-phenylethenesulfonyl fluoride		/	Unkown
HY-164829	Mal-C5-Gly-Gly-Phe-MMAE		/	Unkown
HY-16567S	Asenapine-13C,d3 hydrochloride	Antagonist	/	Unkown
HY-16637S2	(Rac)-Folic acid-13C5,15N		/	Unkown
HY-16637S4	Folic acid-13C5,15N		/	Unkown
HY-168039	Boc-NH-Piperidine-C5-OH		/	Unkown
HY-168040	Thalidomide-O-C5-piperidine-NH-Boc		/	Unkown
HY-168175	PROTAC HDAC8 Degrader-2	Degrader	/	Unkown
HY-169010	Pomalidomide-CO-C5-Br		/	Unkown
HY-17383S	Levomefolate-13C5 calcium	Chemical	/	Unkown
HY-18252S1	Avanafil-13C5,15N,d2		/	Unkown
HY-19528S1	SAH-13C5		/	Unkown
HY-21994	Org-12962 hydrochloride	Agonist	/	Unkown
HY-32351AS1	Calcifediol-13C5 monohydrate		/	Unkown
HY-B0152S2	Adenine-13C5,15N5	Chemical	/	Unkown
HY-B0389S17	D-Glucose-13C-5		/	Unkown
HY-B0434S	Ribavirin-13C5	Inhibitor	/	Unkown
HY-B0456S2	Riboflavin-13C5		/	Unkown
HY-B1654S	Flavin adenine dinucleotide-13C5 ammonium		/	Unkown
HY-D1592	BODIPY TMR C5-maleimide		/	Unkown
HY-D1611	BODIPY FL-C5 NHS Ester		/	Unkown
HY-I1111S2	Fmoc-L-Val-OH-13C5,15N	Inhibitor	≥98%	Unkown
HY-I1111S3	Fmoc-L-Val-OH-13C5		/	Unkown
HY-N0210S4	D-Galactose-13C-5		/	Unkown
HY-N0379S10	D-Mannose-13C-5		/	Unkown
HY-N0437S1	Progesterone-13C5	Agonist	/	Unkown
HY-N0717S2	L-Valine-13C5,15N,d8		/	Unkown
HY-N0717S3	L-Valine-13C5,15N,d2		/	Unkown
HY-N12728	Heteroclitin G		/	Unkown
HY-N13081	3-Oxo-cinobufagin		/	Unkown
HY-N3406	Lansiumarin C		/	Unkown
HY-P10653	C5A	Inhibitor	/	Unkown
HY-P3502A	Zilucoplan TFA	Inhibitor	/	Unkown
HY-P4820	SYNV-cyclo(CGGYF)	Inhibitor	/	Unkown
HY-P4971	C5a Anaphylatoxin (human)	Modulator	/	Unkown
HY-R00334	hsa-miR-181c-5p mimic		/	Unkown
HY-R00334A	hsa-miR-181c-5p agomir		/	Unkown
HY-R00408	hsa-miR-200c-5p mimic		/	Unkown
HY-R00408A	hsa-miR-200c-5p agomir		/	Unkown
HY-R00514	hsa-miR-29c-5p mimic		/	Unkown
HY-R00514A	hsa-miR-29c-5p agomir		/	Unkown
HY-R00718	hsa-miR-34c-5p mimic		/	Unkown
HY-R00718A	hsa-miR-34c-5p agomir		/	Unkown
HY-R00833	hsa-miR-374c-5p mimic		/	Unkown
HY-R00833A	hsa-miR-374c-5p agomir		/	Unkown
HY-R00841	hsa-miR-376c-5p mimic		/	Unkown
HY-R00841A	hsa-miR-376c-5p agomir		/	Unkown
HY-R01113	hsa-miR-449c-5p mimic		/	Unkown
HY-R01113A	hsa-miR-449c-5p agomir		/	Unkown
HY-R01547	hsa-miR-513c-5p mimic		/	Unkown
HY-R01547A	hsa-miR-513c-5p agomir		/	Unkown
HY-R01569A	hsa-miR-518c-5p agomir		/	Unkown
HY-R02507	hsa-miR-892c-5p mimic		/	Unkown
HY-R02507A	hsa-miR-892c-5p agomir		/	Unkown
HY-R02796	mmu-miR-1970c-5p mimic		/	Unkown
HY-R02796A	mmu-miR-1970c-5p agomir		/	Unkown
HY-R02834	mmu-miR-216c-5p mimic		/	Unkown
HY-R02834A	mmu-miR-216c-5p agomir		/	Unkown
HY-R02841	mmu-miR-219c-5p mimic		/	Unkown
HY-R02841A	mmu-miR-219c-5p agomir		/	Unkown
HY-R02883	mmu-miR-297c-5p mimic		/	Unkown
HY-R02883A	mmu-miR-297c-5p agomir		/	Unkown
HY-R02898	mmu-miR-302c-5p mimic		/	Unkown
HY-R02898A	mmu-miR-302c-5p agomir		/	Unkown
HY-R03044	mmu-miR-344c-5p mimic		/	Unkown
HY-R03044A	mmu-miR-344c-5p agomir		/	Unkown
HY-R03105	mmu-miR-374c-5p mimic		/	Unkown
HY-R03105A	mmu-miR-374c-5p agomir		/	Unkown
HY-R03112	mmu-miR-376c-5p mimic		/	Unkown
HY-R03112A	mmu-miR-376c-5p agomir		/	Unkown
HY-R03149	mmu-miR-449c-5p mimic		/	Unkown
HY-R03149A	mmu-miR-449c-5p agomir		/	Unkown
HY-R03164	mmu-miR-465c-5p mimic		/	Unkown
HY-R03164A	mmu-miR-465c-5p agomir		/	Unkown
HY-R03171	mmu-miR-466c-5p mimic		/	Unkown
HY-R03171A	mmu-miR-466c-5p agomir		/	Unkown
HY-R03199	mmu-miR-467c-5p mimic		/	Unkown
HY-R03199A	mmu-miR-467c-5p agomir		/	Unkown
HY-R03461	mmu-miR-669c-5p mimic		/	Unkown
HY-R03461A	mmu-miR-669c-5p agomir		/	Unkown
HY-R04278	rno-miR-196c-5p mimic		/	Unkown
HY-R04278A	rno-miR-196c-5p agomir		/	Unkown
HY-R04285	rno-miR-200c-5p mimic		/	Unkown
HY-R04285A	rno-miR-200c-5p agomir		/	Unkown
HY-R04448	rno-miR-376c-5p mimic		/	Unkown
HY-R04448A	rno-miR-376c-5p agomir		/	Unkown
HY-R04485	rno-miR-466c-5p mimic		/	Unkown
HY-R04485A	rno-miR-466c-5p agomir		/	Unkown
HY-RI00007	hsa-let-7c-5p inhibitor		/	Unkown
HY-RI00334A	hsa-miR-181c-5p antagomir		/	Unkown
HY-RI00408	hsa-miR-200c-5p inhibitor		/	Unkown
HY-RI00408A	hsa-miR-200c-5p antagomir		/	Unkown
HY-RI00514	hsa-miR-29c-5p inhibitor		/	Unkown
HY-RI00514A	hsa-miR-29c-5p antagomir		/	Unkown
HY-RI00718	hsa-miR-34c-5p inhibitor		/	Unkown
HY-RI00718A	hsa-miR-34c-5p antagomir		/	Unkown
HY-RI00833	hsa-miR-374c-5p inhibitor		/	Unkown
HY-RI00833A	hsa-miR-374c-5p antagomir		/	Unkown
HY-RI00841	hsa-miR-376c-5p inhibitor		/	Unkown
HY-RI00841A	hsa-miR-376c-5p antagomir		/	Unkown
HY-RI01113	hsa-miR-449c-5p inhibitor		/	Unkown
HY-RI01113A	hsa-miR-449c-5p antagomir		/	Unkown
HY-RI01547	hsa-miR-513c-5p inhibitor		/	Unkown
HY-RI01547A	hsa-miR-513c-5p antagomir		/	Unkown
HY-RI01569	hsa-miR-518c-5p inhibitor		/	Unkown
HY-RI01569A	hsa-miR-518c-5p antagomir		/	Unkown
HY-RI02507	hsa-miR-892c-5p inhibitor		/	Unkown
HY-RI02507A	hsa-miR-892c-5p antagomir		/	Unkown
HY-RI02796	mmu-miR-1970c-5p inhibitor		/	Unkown
HY-RI02796A	mmu-miR-1970c-5p antagomir		/	Unkown
HY-RI02834	mmu-miR-216c-5p inhibitor		/	Unkown
HY-RI02834A	mmu-miR-216c-5p antagomir		/	Unkown
HY-RI02841	mmu-miR-219c-5p inhibitor		/	Unkown
HY-RI02841A	mmu-miR-219c-5p antagomir		/	Unkown
HY-RI02883	mmu-miR-297c-5p inhibitor		/	Unkown
HY-RI02883A	mmu-miR-297c-5p antagomir		/	Unkown
HY-RI02898	mmu-miR-302c-5p inhibitor		/	Unkown
HY-RI02898A	mmu-miR-302c-5p antagomir		/	Unkown
HY-RI03044	mmu-miR-344c-5p inhibitor		/	Unkown
HY-RI03044A	mmu-miR-344c-5p antagomir		/	Unkown
HY-RI03105	mmu-miR-374c-5p inhibitor		/	Unkown
HY-RI03105A	mmu-miR-374c-5p antagomir		/	Unkown
HY-RI03112	mmu-miR-376c-5p inhibitor		/	Unkown
HY-RI03112A	mmu-miR-376c-5p antagomir		/	Unkown
HY-RI03149	mmu-miR-449c-5p inhibitor		/	Unkown
HY-RI03149A	mmu-miR-449c-5p antagomir		/	Unkown
HY-RI03164	mmu-miR-465c-5p inhibitor		/	Unkown
HY-RI03164A	mmu-miR-465c-5p antagomir		/	Unkown
HY-RI03171	mmu-miR-466c-5p inhibitor		/	Unkown
HY-RI03171A	mmu-miR-466c-5p antagomir		/	Unkown
HY-RI03199	mmu-miR-467c-5p inhibitor		/	Unkown
HY-RI03199A	mmu-miR-467c-5p antagomir		/	Unkown
HY-RI03461	mmu-miR-669c-5p inhibitor		/	Unkown
HY-RI03461A	mmu-miR-669c-5p antagomir		/	Unkown
HY-RI04278	rno-miR-196c-5p inhibitor		/	Unkown
HY-RI04278A	rno-miR-196c-5p antagomir		/	Unkown
HY-RI04285	rno-miR-200c-5p inhibitor		/	Unkown
HY-RI04285A	rno-miR-200c-5p antagomir		/	Unkown
HY-RI04448	rno-miR-376c-5p inhibitor		/	Unkown
HY-RI04448A	rno-miR-376c-5p antagomir		/	Unkown
HY-RI04485	rno-miR-466c-5p inhibitor		/	Unkown
HY-RI04485A	rno-miR-466c-5p antagomir		/	Unkown
HY-RS01749	C5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01750	C5AR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01751	C5AR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12597	SDR16C5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W000450S	5-Aminolevulinic acid-13C		/	Unkown
HY-W008371S1	Fmoc-Met-OH-13C5,15N		/	Unkown
HY-W008585	Benzo-15-crown-5-ether		≥98.0%	Unkown
HY-W008820S2	Glutaric acid-d2		/	Unkown
HY-W009538S1	5-Fluoro-5'-deoxycytidine-13C5		/	Unkown
HY-W013780S1	Fmoc-Pro-OH-13C5,15N	Inhibitor	/	Unkown
HY-W015913S4	2-Oxopropanoate-13c2 sodium		/	Unkown
HY-W016145S	L-Glutamic acid-13C5 hydrate salt		/	Unkown
HY-W017401S	Benzisothiazolinone-13C5	Inhibitor	/	Unkown
HY-W040047S	Pregnanediol 3-glucuronide-13C5		/	Unkown
HY-W040055S	Neopterin-13C5		/	Unkown
HY-W096134	Benzyloxy-C5-PEG1		/	Unkown
HY-W400722	Sodium 3-methyl-2-oxobutanoate-13C5,d1		/	Unkown
HY-W777286	rac-Lenalidomide-13C5		/	Unkown
HY-W800802	BP Lipid 227		/	Unkown
HY-W877850	Mal-C5-N-bis(PEG2-C2-acid)		96.25%	Unkown
HY-Y0252S6	L-Proline-13C5,15N,d7		/	Unkown
HY-Y1055S2	Guanine-13C5,15N5	Chemical	/	Unkown
HY-106178D	PMX 53 monoacetate		/	Unkown
HY-106400	EGIS 11150	Antagonist	/	Unkown
HY-113209S2	8-Isoprostaglandin F2α-13C5		/	Unkown
HY-113266S	Valerylcarnitine-d9		/	Unkown
HY-117872	Sartorypyrone A		/	Unkown
HY-124310	PDE5-IN-6c		/	Unkown
HY-133411A	NH2-O-C5-COOH hydrobromide		/	Unkown
HY-143704S	5-Aminosalicylic acid-13C6 hydrochloride		/	Unkown
HY-144345S	L-γ-Glutamyl-L-cysteinyl-L-lysine-13C5,15N		/	Unkown
HY-14541A	Olanzapine hydrochloride		/	Unkown
HY-14541S2	Olanzapine-d8		/	Unkown
HY-147338S1	5-Methylcytidine 5′-triphosphate-15N2,13C trisodium		/	Unkown
HY-149562	Thalidomide-5-O-C5-NH2 hydrochloride		/	Unkown
HY-149691	O-Phthalimide-C1-S-C5-acid		/	Unkown
HY-15401A	WAY 163909 hydrochloride		/	Unkown
HY-15543	CP-809101	Agonist	/	Unkown
HY-158382	NH2-C4-PEG4-C5-COOH		/	Unkown
HY-158992S	SP-(Val-13C5,15N)-EKNQ-(Leu-13C6,15N)-TIDFINIVKDPVPHNEYKT TFA		/	Unkown
HY-159046S	ASGITFSNSGMHW(Val-13C5,15N)R TFA		/	Unkown
HY-159064S	DSPSAPVNVT(Val-13C5,15N)R TFA		/	Unkown
HY-159065S	FIQE(Val-13C5,15N)NTTTR TFA		/	Unkown
HY-160235	Pomalidomide-C2-amide-C5-azide		/	Unkown
HY-160901	CP-289,503	Inhibitor	/	Unkown
HY-161792	N3-C5-O-C-Boc		/	Unkown
HY-162948	(S,R,S)-AHPC-PEG2-C5-N3		/	Unkown
HY-162949	Piperidin-4-amine-C5-O-C1		/	Unkown
HY-162950	Piperidin-4-amine-C5-O-C1-Thalidomide		/	Unkown
HY-50719S1	2-Acetyl-1-pyrroline-13C5		/	Unkown
HY-76082S1	L-Pyroglutamic acid-13C5		/	Unkown
HY-A0003S2	Lenalidomide-13C5,15N	Inducer	/	Unkown
HY-B0152S3	Adenine-13C5	Chemical	/	Unkown
HY-B2130S2	Uric acid-13C5		/	Unkown
HY-N13147	Tetromycin C5	Inhibitor	/	Unkown
HY-P10639A	C5aR2 agonist P32 acetate	Agonist	/	Unkown
HY-P3502B	Zilucoplan (PEG2)	Inhibitor	/	Unkown
HY-W039426	N-Trityl-N4-benzoyl-morpholino-C-5'-O-phosphoramidite		/	Unkown
HY-W130878	4-Octylphenol	Activator	/	Unkown
HY-W251144	N,N′-Dipentyl-3,4,9,10-perylenedicarboximide		/	Unkown
HY-W728005	Covidcil-19	Inhibitor	/	Unkown
HY-W778207	2'-Deoxyadenosine-13C5 monohydrate		/	Unkown
HY-W779800	D-α-Hydroxyglutaric acid-13C5 disodium		/	Unkown
HY-W814363	Octadec-9-enoic acid-13C5		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990745	Izastobart	Ligand	/	Unkown
HY-P990753	Omoprubart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	C5	VGNC	VGNC:60232
Bos taurus	C5	VGNC	VGNC:49997
Macaca mulatta	C5	VGNC	VGNC:70475
Canis familiaris	C5	VGNC	VGNC:38595
Rattus norvegicus	C5	RGD	RGD:2237
Mus musculus	C5	MGD	MGI:96031
Macaca fascicularis	C5	NCBI	NCBI:102125658
Susscrofa domestica	C5	NCBI
Others	C5	NCBI

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