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MAO A inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Monoamine Oxidase (251) 5-HT Receptor (8) Adenosine Receptor (2) Adrenergic Receptor (6) Amyloid-β (5) Antibiotic (4) Apoptosis (14) Autophagy (6) Bacterial (5) Bcl-2 Family (3) Carbonic Anhydrase (1) Caspase (1) Cholinesterase (ChE) (34) COMT (9) COX (1) Cytochrome P450 (6) Dopamine Transporter (2) Dopamine β-hydroxylase (3) Drug Metabolite (2) DYRK (1) EGFR (2) Endogenous Metabolite (7) Enterovirus (2) ERK (2) Estrogen Receptor/ERR (1) Ferroptosis (1) Fluorescent Dye (1) GABA Receptor (3) Guanylate Cyclase (6) HDAC (5) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (1) Histone Demethylase (20) HSP (2) HSV (2) IAP (1) Imidazoline Receptor (6) Influenza Virus (2) Interleukin Related (1) Isotope-Labeled Compounds (10) Lipoxygenase (1) Microtubule/Tubulin (5) nAChR (3) NF-κB (4) NO Synthase (7) Opioid Receptor (3) Parasite (1) PARP (2) PGC-1α (4) PKC (2) Reactive Oxygen Species (4) Reverse Transcriptase (2) Serotonin Transporter (1) Survivin (2) Tau Protein (1) Telomerase (2) TGF-beta/Smad (1) α-synuclein (1)
By Research Areas:	Cancer (59) Cardiovascular Disease (15) Endocrinology (3) Infection (20) Inflammation/Immunology (25) Metabolic Disease (6) Neurological Disease (221)
Click Chemistry:	Alkynes (18)

277

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Monoamine Oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156255

MAO-B-IN-25	Monoamine Oxidase	Neurological Disease
MAO-B-IN-25 (compound 92) is a selective *MAO-B* inhibitor with IC₅₀s of 0.5 nM and 240 nM for MAO-A and MAO-B, respectively .

HY-16677A

Mofegiline hydrochloride MDL72974A	Monoamine Oxidase	Neurological Disease
Mofegiline hydrochloride (MDL72974A) is an orally active and selective enzyme-activated irreversible inhibitor of *MAO-B, with marked selectivity on the MAO-B* over *MAO-A* with IC₅₀s of 3.6 nM (MAO-B) and 680 nM (MAO-A), respectively. Mofegiline hydrochloride is also an inhibitor of semicarbazide-sensitive amine oxidase (SSAO) .

HY-163322

MAO-A inhibitor 2	Monoamine Oxidase	Neurological Disease
MAO-A inhibitor 2 (compound HT4) is a monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 14.3 µM. MAO-A inhibitor 2 shows a less effect on MAO-B (IC₅₀ of 106 µM) and shows almost ineffective on xanthine oxidase (XO). MAO-A inhibitor 2 can be used for the neurodegenerative disorders and oxidative stress research .

HY-N12485

MAO-A inhibitor 1	Monoamine Oxidase	Cancer
MAO-A inhibitor 1 (compound VIII) is a *MAO-A* inhibitor, with an IC₅₀ of 100 μM .

HY-142706

MAO A/HDAC-IN-1	Monoamine Oxidase HDAC	Cancer
MAO A/HDAC-IN-1 is a dual?inhibitor?of *monoamine oxidase A (MAO* A) and HDAC*. MAO* A/HDAC-IN-1 can be used for glioma research . MAO A/HDAC-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-163474

MAO-B-IN-32	Monoamine Oxidase	Neurological Disease
MAO-B-IN-32 is an inhibitor of *MAO-B* (IC₅₀ = 16 nM).MAO-B-IN-32 increases dopamine concentration in the brain by inhibiting MAO-B activity .

HY-149515

MAO-IN-3	Monoamine Oxidase	Cancer
MAO-IN-3 (Compound 5) is a reversible and competitive *MAO* inhibitor (K_i: 0.6 and 0.2 μM for MAO A and MAO B). MAO-IN-3 inhibits LN-229 glioblastoma cell proliferation with an IC₅₀ of 0.8 μM. MAO-IN-3 can be used for cancer research .

HY-151800

MAO-A/B-IN-2	Monoamine Oxidase	Neurological Disease
MAO-A/B-IN-2 (compound 30) is a *MAO-A/B* inhibitor with IC₅₀ values of 17.8 and 15.8 μM for *MAO-A* and *MAO-B, respectively. MAO*-A/B-IN-2 can be used in the study of neurological disorders .

HY-152109

AChE/MAO-IN-1	Cholinesterase (ChE) Monoamine Oxidase Amyloid-β	Neurological Disease
AChE/MAO-IN-1 (Compound D28) is a potent AChE, *MAO-A* and *MAO-B* inhibitor with IC₅₀s of 0.0248, 0.0409 and 0.1108 μM against human AChE, MAO-B and MAO-A, respectively .

HY-158732

MAO-B-IN-33	Monoamine Oxidase	Inflammation/Immunology
MAO-B-IN-33 (compound C3) is a potent, reversible and selective monoamine oxidase-B (MAO-B) inhibitor with an IC₅₀ of 0.021 μM and 26.805 μM for MAO-B and MAO-A, respectively. The selectivity of MAO-B-IN-33 is attributed to the steric clash arising from the residue differences between Phe208 (MAO-A) and Ile199 (MAO-B). MAO-B-IN-33 inhibits cerebral MAO-B activity and alleviates MPTP (HY-15608)-induced dopaminergic neuronal loss in the mouse. MAO-B-IN-33 has the potential for Parkinson's disease research .

HY-157934

MAO-IN-4	Monoamine Oxidase	Neurological Disease
MAO-IN-4 (Compound 2l) is a monoamine oxidase (MAO) inhibitor, with IC₅₀ values of 0.07 and 0.75 μM for MAO-A and MAO-B Enzymes, respectively. MAO-IN-4 can be used for the research of depression and Parkinson’s disease (PD) .

HY-146958

MAO-B-IN-8 1 Publications Verification	Monoamine Oxidase	Neurological Disease
MAO-B-IN-8 is a potent reversible *MAO-B* inhibitor and an inhibitor of microglial production of neuroinflammatory mediator. MAO-B-IN-8 can be used for neurodegenerative disease research .

HY-U00015

MAO-IN-1	Monoamine Oxidase	Neurological Disease
MAO-IN-1 is a monoamine oxidase B (MAO B) inhibitor with an IC₅₀ of 20 nM.

HY-101169

Tetrindole mesylate	Monoamine Oxidase	Neurological Disease
Tetrindole mesylate is a selective inhibitor of *monoamine oxidase A (MAO* A)*. Tetrindole mesylate inhibits* rat brain mitochondrial MAO A in a competitive manner with a K_i value of 0.4 μM and inhibits MAO B with a K_i of 110 μM. Tetrindole mesylate has antidepressant activity .

HY-13339

Brofaromine CGP 11305A	Monoamine Oxidase	Neurological Disease
Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC₅₀ of 0.2 μM for *MAO-A*.

HY-157517

MAO-B-IN-29	Monoamine Oxidase	Neurological Disease
MAO-B-IN-29 (compound 9a) is a inhibitor against *MAO-B* activity .

HY-157087

AChE/MAO-B-IN-4	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
AChE/MAO-B-IN-4 (compound 4a) is a selective dual AChE and *MAO-B* inhibitor. AChE/MAO-B-IN-4 shows no significant inhibition activity against BChE and h-MAO-A. AChE/MAO-B-IN-4 can be used for the Alzheimer’s disease (AD) research .

HY-157089

AChE/MAO-B-IN-5	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/MAO-B-IN-5 is a dual inhibitor of AChE and *MAO-B. AChE/MAO*-B-IN-5 can used in study Alzheimer’s disease .

HY-160002

MAO-B-IN-27	Monoamine Oxidase	Neurological Disease
MAO-B-IN-27 (Compound 12c) is a monoamine oxidase B (MAO-B) inhibitor. MAO-B-IN-27 has potent and selective MAO-B inhibitory effect for hMAO-B with an IC₅₀ values of 8.9 nM. MAO-B-IN-27 can be used for the research of parkinson's disease (PD) .

HY-161240

MAO-B-IN-30	Monoamine Oxidase	Neurological Disease Inflammation/Immunology
MAO-B-IN-30 (compound IS7) is a potent, selective and cross the blood-brain barrier *MAO-B* inhibitor with IC₅₀ values of 19.176, 0.082 µM for MAO-A and MAO-B, respectively. MAO-B-IN-30 shows antiproliferative activity and non-cytotoxic. MAO-B-IN-30 reduces TNF-alpha, IL-6, NF-kB levels. MAO-B-IN-30 has the potential for the research of Parkinson's disease .

HY-168138

MAO-B-IN-34	Monoamine Oxidase	Cancer
MAO-B-IN-34 (compund 3d) is a monoamine oxidase *MAO-B* inhibitor .

HY-162061

ChEs/MAOs-IN-1	Monoamine Oxidase	Neurological Disease
ChEs/MAOs-IN-1 (Compound 4i) is a dual inhibitor of cholinesterases (ChEs) and monoamine oxidases (MAOs).ChEs/MAOs-IN-1 has IC₅₀ values of 0.048 μM, 0.89 μM, 3.58 μM, and 0.095 μM for AChE, BChE, *MAO-B* and *MAO-B* respectively. ChEs/MAOs-IN-1 can be used in the study of neurodegenerative diseases .

HY-121072

ASS234	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
ASS234 is a potent monoamino oxidase (MAO) inhibitor with IC₅₀s of 5.2 nM and 43 nM for MAO-A and MAO-B, respectively. ASS234 also inhibits AChE and BuChE with IC₅₀s of 350 nM and 460 nM, respectively .

HY-168590

MAO-B-IN-36	Monoamine Oxidase	Neurological Disease
MAO-B-IN-36 (Compound A6) is a potent *MAO-B* inhibitor with an IC₅₀ of 13 nM .

HY-163415

MAO-IN-5	Monoamine Oxidase	Neurological Disease
MAO-IN-5 (Compound ZINC000016952895) is a monoamine oxidase (MAO) inhibitor. According to the prediction of Swiss ADME, MAO-IN-5 can inhibit the CYP enzyme family, has blood-brain barrier (BBB) permeability, and has a high gastrointestinal absorption rate. MAO-IN-5 can be used in the study of neurological diseases .

HY-157090

AChE/MAO-B-IN-6	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/MAO-B-IN-6 (compound 3a) is a dual inhibitor of AChE and h-MAO-B with potential to inhibit Alzheimer's disease .

HY-147362

MAO-B-IN-14	Monoamine Oxidase	Neurological Disease
MAO-B-IN-14 (Compound 9) is a potent and selective monoamine oxidase-B (MAO-B) inhibitor with an IC₅₀ of 0.95 μM and a K_i of 0.55 μM against human MAO-B.

HY-123665

PSB-1410	Monoamine Oxidase	Neurological Disease
PSB-1410 is a selective and competitive monoamine oxidase B (MAO-B) inhibitor with IC₅₀ for human MAO-B and rat MAO-B Values are 0.23 and 1.01 nM respectively .

HY-W335927

MAO-B-IN-19	Monoamine Oxidase	Neurological Disease Inflammation/Immunology
MAO-B-IN-19 is a selective *MAO-B* inhibitor with an IC₅₀ of 0.67 μM. MAO-B-IN-19 shows neuroprotective and anti-inflammatory properties .

HY-115986

MAO-B-IN-5	Monoamine Oxidase	Neurological Disease
MAO-B-IN-5 is a potent, selective and orally active *MAO-B* inhibitor with an IC₅₀ of 0.204 µM. MAO-B-IN-5 has the potential for the research of Parkinson's disease (PD) .

HY-146150

MAO-B-IN-12	Monoamine Oxidase	Neurological Disease
MAO-B-IN-12 (Compound 16c) is a potent monoamine oxidase B (MAO-B) inhibitor with an IC₅₀ of 1.3 μM. MAO-B-IN-12 shows a neuroprotective activity .

HY-146149

MAO-B-IN-11	Monoamine Oxidase	Neurological Disease
MAO-B-IN-11 (Compound 8c) is a potent monoamine oxidase B (MAO-B) inhibitor with an IC₅₀ of 1.3 μM. MAO-B-IN-11 shows a neuroprotective activity .

HY-131624

LON 954	Monoamine Oxidase	Neurological Disease
LON 954, a tremorogenic agent, is a reversible monoamine oxidase (MAO) inhibitor. LON 954 inhibits MAO activity in various tissue preparations .

HY-143330

MAO-B-IN-4	Monoamine Oxidase	Neurological Disease
MAO-B-IN-4 (Compound 26) is an orally active and reversible *MAO-B* inhibitor with an IC₅₀ of 9 nM. MAO-B-IN-4 has good metabolic stability, safety profile and brain permeability. MAO-B-IN-4 shows antidepressant activity in rats and mice. MAO-B-IN-4 can be used in studies related to Alzheimer's disease .

HY-156348

MAO-B-IN-26	Monoamine Oxidase Autophagy Apoptosis Cholinesterase (ChE)	Neurological Disease
MAO-B-IN-26 (Compound IC9) is a *MAO-B* and acetylcholinesterase inhibitor. MAO-B-IN-26 protects SH?SY5Y cells against Aβ induced cytotoxicity, morphological changes, ROS generation and membrane damage. MAO-B-IN-26 also inhibits Aβ induced autophagy and apoptosis. MAO-B-IN-26 can be used as a neuroprotective agent against Alzheimer’s disease .

HY-115987

MAO-B-IN-6	Monoamine Oxidase	Neurological Disease
MAO-B-IN-6 is a potent, selective and orally active *MAO-B* inhibitor with an IC₅₀ of 0.019 µM. MAO-B-IN-6 shows more efficacious than Safinamide in vitro and in vivo. MAO-B-IN-6 has the potential for the research of parkinson's disease (PD) .

HY-149242

MAO-B-IN-20	Monoamine Oxidase	Neurological Disease
MAO-B-IN-20 (Compound C14) is a potent *MAO-B* inhibitor with an IC₅₀ of 0.037 μM. MAO-B-IN-20 displays good metabolic stability and brain-blood barrier permeability. MAO-B-IN-20 can be used for the research of Parkinson's disease .

HY-N0505

Rosiridin	Monoamine Oxidase	Neurological Disease
Rosiridin inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC₅₀=5.38) .

HY-151210

MAO-B-IN-17	Monoamine Oxidase	Neurological Disease
MAO-B-IN-17 is a selective monoamine oxidase B (MAO-B) inhibitor with the IC₅₀ value of 5.08 μM. MAO-B-IN-17 can be used in Parkinson’s disease research .

HY-14855B

Tedizolid phosphate 2 Publications Verification TR-701FA	Bacterial Antibiotic Monoamine Oxidase	Infection
Tedizolid phosphate (TR-701FA) is a *MAO-A* and *MAO-B* inhibitor with activity against Gram-positive bacteria .

HY-105041

Tedizolid phosphate sodium TR-701FA sodium	Antibiotic Bacterial Monoamine Oxidase	Infection
Tedizolid phosphate (TR-701FA) sodium is a *MAO-A* and *MAO-B* inhibitor with activity against Gram-positive bacteria .

HY-158092

ChEs/MAOs-IN-2	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
ChEs/MAOs-IN-2 (compound a11) is a cholinesterases and monoamine oxidases inhibitor with IC₅₀ values of 0.10, 0.20, 0.30, 0.40 µM for MAO-A, MAO-B, AChE, and BChE, respectively. ChEs/MAOs-IN-2 has the potential for the research of Alzheimer's disease .

HY-143329

MAO-B-IN-3	Monoamine Oxidase 5-HT Receptor	Neurological Disease
MAO-B-IN-3 is a reversible and selective *MAO-B* inhibitor (IC₅₀=96 nM). MAO-B-IN-3 also binds to 5-HT₆R with K_i value of 696 nM. MAO-B-IN-3 can be used for research of in Alzheimer's disease .

HY-168021

MAO-A/SERT-IN-1	Monoamine Oxidase Serotonin Transporter	Neurological Disease
MAO-A/SERT-IN-1 is an inhibitor of *MAO-A*/serotonin transporter (SERT). MAO-A/SERT-IN-1 can reduce SERT-mediated reuptake of 5-HT and has neuroprotective effects in cell inhibition models. MAO-A/SERT-IN-1 can improve depressive behavior in zebrafish and mice .

HY-151208

MAO-B-IN-16	Monoamine Oxidase	Neurological Disease
MAO-B-IN-16 is a selective monoamine oxidase B (MAO-B) inhibitor, with an IC₅₀ of 1.55 µM. MAO-B-IN-16 can be used in the study of central nervous disorders, such as parkinson's disease .

HY-162606

MAO-A/B-IN-3	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
MAO-A/B-IN-3 (Compound 12) stands out as a key dual *MAO-AChE* inhibitor, displaying excellent multi-target efficacy against *MAO-A, MAO-B, and AChE* with IC₅₀ values of 67 nM, 29 nM, and 1370 nM respectively. MAO-A/B-IN-3 is adept at altering the A site (hydrophobic ring) and C site (semicarbazone chain) within ketone amine-based MTDLs to bolster the inhibitory potential against *MAO-A/B* while notably diminishing activity against AChE. MAO-A/B-IN-3 is poised for research applications in the field of neurodegenerative diseases .

HY-145708

Dual AChE-MAO B-IN-2	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
Dual AChE-MAO B-IN-2 is a potent AChE and MAO B dual inhibitor with IC₅₀s of 0.12 µM and 0.01 µM for b>AChE and MAO B, respectively. Dual AChE-MAO B-IN-2 has the potential for the research of Alzheimer’s disease .

HY-147953

MAO-B-IN-13	Monoamine Oxidase	Neurological Disease
MAO-B-IN-13 (compound 12a) is a highly potent, reversible and blood-brain barrier (BBB) penetrant *MAO-B* inhibitor with an IC₅₀ value of 10 nM. MAO-B-IN-13 has neuroprotective and antioxidant activity. MAO-B-IN-13 can be used for researching Parkinson’s disease .

HY-125515

Tetrahydroharmine Leptaflorine	Monoamine Oxidase	Neurological Disease
Tetrahydroharmine (Leptaflorine) is A monoamine oxidase (MAO) inhibitor with a IC₅₀ value of 74 nM for MAO-A. Tetrahydroharmine can be used in the study of neurodegenerative diseases .

HY-146347

MAO-B-IN-10	Monoamine Oxidase Amyloid-β	Neurological Disease
MAO-B-IN-10 (compound 4f) is a potent, selective, BBB-penetrated *MAO-B* (monoamine oxidase-B) inhibitor, with IC₅₀ of 5.3 μM. MAO-B-IN-10 can inhibit (58.2%) and disaggregate (43.3%) self-mediated Aβ (amyloid β) aggregation. MAO-B-IN-10 can be use for Alzheimer’s disease research .

Cat. No.	Product Name	Type

HY-D0004

Azure B Azure B chloride	Dyes
Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC₅₀s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

HY-14536

Methylene Blue

15+ Cited Publications

Basic Blue 9; CI-52015; Methylthioninium chloride

Chromogenic Assays

Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

HY-D0004R

Azure B (Standard)

Dyes

Azure B (Standard) is the analytical standard of Azure B. This product is intended for research and analytical applications. Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects .

HY-17447AG

Tranylcypromine hydrochloride (GMP) SKF 385 hydrochloride (GMP)	Fluorescent Dye
Tranylcypromine (SKF 385) hydrochloride (GMP) is Tranylcypromine (HY-17447) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tranylcypromine hydrochloride is a potent monoamine oxidase (MAO) inhibitor .

HY-14536A

Methylene blue (purity≥70%)

Basic Blue 9 (purity≥70%); CI-52015 (purity≥70%); Methylthioninium chloride (purity≥70%)

Chromogenic Assays

Methylene blue (purity≥70%) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue (purity≥70%) is a vasopressor and is often used as a dye in several medical procedures. Methylene blue (purity≥70%) through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue (purity≥70%) is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue (purity≥70%) is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

HY-14536R

Methylene Blue (Standard)

Chromogenic Assays

Methylene Blue (Standard) is the analytical standard of Methylene Blue. This product is intended for research and analytical applications. Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

Cat. No.	Product Name	Type

HY-17447AG

Tranylcypromine hydrochloride (GMP) SKF 385 hydrochloride (GMP)	Biochemical Assay Reagents
Tranylcypromine (SKF 385) hydrochloride (GMP) is Tranylcypromine (HY-17447) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Tranylcypromine hydrochloride is a potent monoamine oxidase (MAO) inhibitor .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0505

Rosiridin	Other Monoterpenes Rhodiola rosea Linn. Terpenoids Source classification Crassulaceae Plants	Monoamine Oxidase
Rosiridin inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC₅₀=5.38) .

HY-125515

Tetrahydroharmine Leptaflorine	Structural Classification Alkaloids Banisteriopsis caapi (Spruce ex Griseb.) Morton Source classification Malpighiaceae Plants Indole Alkaloids	Monoamine Oxidase
Tetrahydroharmine (Leptaflorine) is A monoamine oxidase (MAO) inhibitor with a IC₅₀ value of 74 nM for MAO-A. Tetrahydroharmine can be used in the study of neurodegenerative diseases .

HY-N0159

Paeonol 5 Publications Verification	Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Plants Paeoniaceae Disease Research Fields Paeonia suffruticosa Andr. Cancer	Monoamine Oxidase Autophagy
Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits *MAO-A* and *MAO-B* with IC₅₀ of 54.6 μM and 42.5 μM, respectively.

HY-N0529

Rosmarinic acid Maximum Cited Publications 12 Publications Verification Labiatenic acid	Structural Classification Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Source classification Other Phenylpropanoids Phenylpropanoids Plants Endogenous metabolite Disease Research Fields Cancer	Monoamine Oxidase COMT Apoptosis Endogenous Metabolite
Rosmarinic acid is a widespread phenolic ester compound in the plants. Rosmarinic acid inhibits *MAO-A, MAO-B* and COMT enzymes with IC₅₀s of 50.1, 184.6 and 26.7 μM, respectively.

HY-22385

Salsolidine 2 Publications Verification	Alkaloids Structural Classification Animals Source classification Isoquinoline Alkaloids	Monoamine Oxidase
Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.

HY-N2336

Rosmarinic acid racemate Labiatenic acid racemate	Classification of Application Fields Inflammation/Immunology Disease Research Fields	Monoamine Oxidase Endogenous Metabolite
Rosmarinic acid racemate is the racemate of Rosmarinic acid. Rosmarinic acid inhibits *MAO-A, MAO-B* and COMT enzymes with IC₅₀s of 50.1, 184.6 and 26.7 μM, respectively.

HY-N0505R

Rosiridin (Standard)	Structural Classification Other Monoterpenes Rhodiola rosea Linn. Terpenoids Crassulaceae Source classification Plants	Monoamine Oxidase
Rosiridin (Standard) is the analytical standard of Rosiridin. This product is intended for research and analytical applications. Rosiridin inhibits MAO A and MAO B with potential beneficial effect in depression and senile dementia. Rosiridin shows an inhibition of 83.8% against MAO B at 10 μM (pIC50=5.38) .

HY-N13041

Acacetin 7-O-(6-O-malonylglucoside)	Structural Classification Flavonoids Flavones Ligularia veitchiana (Hemsl.) Greenm. Labiatae Source classification Plants	Monoamine Oxidase
Acacetin 7-O-(6-O-malonylglucoside) is a monoamine oxidase inhibitor with strong inhibitory effects on monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC₅₀ values of 2.34 and 1.87 μM, respectively. Acacetin 7-O-(6-O-malonylglucoside) is a reversible *MAO* inhibitor that can be used in the research of neurodegenerative diseases and affective disorders .

HY-22385A

Salsolidine hydrochloride	Alkaloids other families Source classification Plants Isoquinoline Alkaloids	Monoamine Oxidase
Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A (monoamine oxidase A) inhibitor.

HY-N0159R

Paeonol (Standard)	Structural Classification Monophenols Source classification Phenols Plants Paeoniaceae Paeonia suffruticosa Andr.	Monoamine Oxidase Autophagy
Paeonol (Standard) is the analytical standard of Paeonol. This product is intended for research and analytical applications. Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC₅₀ of 54.6 μM and 42.5 μM, respectively.

HY-N0529R

Rosmarinic acid (Standard)	Structural Classification Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Source classification Other Phenylpropanoids Phenylpropanoids Plants Endogenous metabolite	Monoamine Oxidase COMT Apoptosis Endogenous Metabolite
Rosmarinic acid (Standard) is the analytical standard of Rosmarinic acid. This product is intended for research and analytical applications. Rosmarinic acid is a widespread phenolic ester compound in the plants. Rosmarinic acid inhibits MAO-A, MAO-B and COMT enzymes with IC₅₀s of 50.1, 184.6 and 26.7 μM, respectively.

HY-N1638

1-Methyl-2-undecyl-4(1H)-quinolone	Alkaloids Structural Classification Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Quinoline Alkaloids Plants	Monoamine Oxidase
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of *MAO-B* activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS .

HY-N8315

Echitovenidine	Apocynaceae Structural Classification Alkaloids Alstonia yunnanensis Diels Source classification Plants	Monoamine Oxidase
Echitovenidine is an alkaloid that can be isolated from Alstonia yunnanensis. Echitovenidine is an inhibitor of monoamine oxidase (MAO) .

HY-N0918

Desmethoxyyangonin Demethoxyyangonin; 5,6-Dehydrokavain	Structural Classification other families Classification of Application Fields Source classification Other Diseases Other Phenylpropanoids Phenylpropanoids Plants Disease Research Fields	Monoamine Oxidase
Desmethoxyyangonin is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.

HY-134664

8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	Cytochrome P450 Monoamine Oxidase
8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor with IC₅₀s of 8.64 μM and 22.3 μM with pre-incubation and co-incubaition, respectively. 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate also inhibits *MAO-A* and *MAO-B* with IC₅₀s of 60.2 and 38.6 μM, respectively .

HY-22385B

(S)-Salsolidine	Alkaloids Structural Classification Source classification Salsola Plants Isoquinoline Alkaloids Chenopodiaceae	Monoamine Oxidase Endogenous Metabolite
(S)-Salsolidine is a weak monoamine oxidase (MAO) inhibitor (K_i=63 μM). The R enantiomer of Salsolidine is more potent than the S form (K_i=26 μM) .

HY-W008566

Norharmane Norharman; β-Carboline	Structural Classification Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Biological Pesticide Research Indole Alkaloids Agricultural Research Infection Alkaloids Microorganisms Disease Research Fields Cancer	Monoamine Oxidase Endogenous Metabolite
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for *MAO-A* and *MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting* PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

HY-N9540

Methyl citrate	Structural Classification Cactaceae Ketones, Aldehydes, Acids Source classification Opuntia ficus-indica (L.) Mill. Plants	Monoamine Oxidase
Methyl citrate is a Monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.23 mM). Methyl citrate is isolated from the fruits of Opuntia ficus-indica var. saboten Makino .

HY-107811R

Harmol (Standard)	Alkaloids Monophenols Zygophyllaceae Peganum harmala Linn. Source classification Phenols Pyridine Alkaloids Plants Endogenous metabolite Indole Alkaloids	Monoamine Oxidase
Harmol (Standard) is the analytical standard of Harmol. This product is intended for research and analytical applications. Harmol categorized as a β-carboline alkaloid. Harmol is a potent MAO inhibitor used as an analytical reference standard .

HY-N9329

Glicoricone	Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones	Monoamine Oxidase Estrogen Receptor/ERR
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC₅₀ of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity .

HY-108048

Desoxypeganine Deoxypeganine; Deoxyvasicine	Structural Classification Alkaloids Peganum nigellastrum Bunge Zygophyllaceae Source classification Quinoline Alkaloids Plants	Cholinesterase (ChE) Monoamine Oxidase
Desoxypeganine (Deoxypeganine), an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective *MAO-A* inhibitor, with IC₅₀ values of 2, 17, and 2 μM, respectively. Desoxypeganine can be used for alcohol abuse research .

HY-W008566R

Norharmane (Standard)	Alkaloids Structural Classification Microorganisms Source classification Pyridine Alkaloids Endogenous metabolite Indole Alkaloids	Monoamine Oxidase Endogenous Metabolite
Norharmane (Standard) is the analytical standard of Norharmane. This product is intended for research and analytical applications. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

HY-N0453

Hypericin 3 Publications Verification	Structural Classification Natural Products Classification of Application Fields Guttiferae Source classification Phenols Polyphenols Hyperlcurn perforatum L. Plants Disease Research Fields Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), *MAO* (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-101392R

Harmane (Standard)	Structural Classification Alkaloids other families Source classification Plants	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor
Harmane (Standard) is the analytical standard of Harmane. This product is intended for research and analytical applications. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC₅₀=30 nM) over α2-adrenoceptor (IC₅₀=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC₅₀s=0.5 and 5 μM for *human MAO* A/B**, respectively). Harmane exhibits comutagenic effect .

HY-Y0265

Isatin Indoline-2,3-dione	Cardiovascular Disease Alkaloids Structural Classification other families Neurological Disease Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids	Monoamine Oxidase Apoptosis
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC₅₀ of 3 μM. Also binds to central benzodiazepine receptors (IC₅₀ against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-N1636

1-Methyl-2-nonyl-4(1H)-quinolone	Alkaloids Neurological Disease Classification of Application Fields Source classification Rutaceae Quinoline Alkaloids Plants Disease Research Fields	Monoamine Oxidase
1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective *MAO-B* (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC₅₀ of 12.1 μM .

HY-N0453R

Hypericin (Standard) 3 Publications Verification	Structural Classification Natural Products Classification of Application Fields Guttiferae Source classification Phenols Hyperlcurn perforatum L. Plants Disease Research Fields Cancer	Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), *MAO* (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis .

HY-N2510

Myristicin Myristicine	Structural Classification Simple Phenylpropanols Source classification Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt.	5-HT Receptor EGFR ERK Apoptosis Bacterial
Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

HY-N2510R

Myristicin (Standard)	Structural Classification Simple Phenylpropanols Source classification Myristicaceae Phenylpropanoids Plants Myristica fragrans Houtt.	5-HT Receptor EGFR ERK Apoptosis Bacterial
Myristicin (Standard) is the analytical standard of Myristicin. This product is intended for research and analytical applications. Myristicine is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc .

HY-Y0265R

Isatin (Standard)	Alkaloids Structural Classification other families Source classification Plants Indole Alkaloids	Monoamine Oxidase Apoptosis
Isatin (Standard) is the analytical standard of Isatin. This product is intended for research and analytical applications. Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM) . Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity . Shows effect on the serotonergic system .

HY-N7204

4-Hydroxyderricin 1 Publications Verification	Structural Classification Chalcones Monophenols Flavonoids Phenols Umbelliferae Plants Ondetia linearis Benth.	Monoamine Oxidase Dopamine β-hydroxylase Apoptosis
4-Hydroxyderricin, the major active ingredients of Angelica keiskei Koidzumi, is an orally active, potent selective **MAO-B (Monoamine oxidase inhibitors)** inhibitor with an IC₅₀ of 3.43 μM. 4-Hydroxyderricin also mildly inhibits dopamine β (DBH)-hydroxylase activity. 4-Hydroxyderricin has antidepressant activity, anti-allergic, anti-diabetic, anti-oxidant, and antitumor effects. 4-Hydroxyderricin promotes apoptosis and cell cycle arrest through regulating PI3K/AKT/mTOR pathway in hepatocellular cells. 4-Hydroxyderricin inhibits osteoclast formation and accelerates osteoblast differentiation . 4-Hydroxyderricin is promising for research of inflammatory diseases .

HY-101392

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, *MAO-A/B, and α2-adrenergic receptor* of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-101392A

Harmane hydrochloride	Apocynaceae Structural Classification Alkaloids Other Alkaloids Source classification Plants Rauwolfia canescens	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane hydrochloride is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, *MAO-A/B, and α2-adrenergic receptor* of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane hydrochloride inhibits the I1 imidazoline receptor (IC₅₀ = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane hydrochloride inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane hydrochloride can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

Cat. No.	Product Name	Chemical Structure

HY-B0678S

Metaxalone-d3

Metaxalone-d₃ is the deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-14280S

Entacapone-d10

Entacapone-d₁₀ is the deuterium labeled Entacapone. Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 µM). Entacapone can be used for the research of Parkinson's disease[1]. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders[2].

HY-B0534S1

Moclobemide-d4
Moclobemide-d₄ is deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-101392S

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-17447AS

(1S,2R)-Tranylcypromine-d5 hydrochloride

(1S,2R)-Tranylcypromine-d₅ (hydrochloride) is the deuterium labeled Tranylcypromine hydrochloride[1]. Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression[2][3][4].

HY-14605S

Rasagiline-13C3 mesylate
Rasagiline- ¹³C₃ ((R)-AGN1135- ¹³C₃; TVP1012- ¹³C₃) mesylate is the deuterium labeled Rasagiline (mesylate) (HY-14605) . Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively .

HY-Y0882S1

Hydroxylamine-d3 hydrochloride
Hydroxylamine-d₃ (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride[1]. Hydroxyamine hydrochloride is a selective monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxyamine hydrochloride is an intermediate of organic synthesis[2].

HY-B0678S1

Metaxalone-d6

Metaxalone-d₆ is deuterium labeled Metaxalone. Metaxalone (AHR438; NSC170959) is an FDA-approved muscle relaxant. Metaxalone acts mainly on the central nervous system and achieves muscle relaxation by inhibiting polysynaptic reflex arcs. In addition, Metaxalone is an inhibitor of MAO-A, which has anti-inflammatory and antioxidant effects. Metaxalone inhibits IL-1β-induced inflammatory phenotype, modulates NF-κB and other related signaling pathways, and decreases MAO-A expression and activity in IL-1β-treated microglia .

HY-W700241

Norharman-d7

Norharman-d₇ is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

HY-17447SA

Tranylcypromine-d5 hydrochloride

Tranylcypromine-d₅ (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis[1][2].

HY-101392S1

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-70057S1

Safinamide-d4-1

Safinamide-d₄-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3].

HY-B0534S

Moclobemide-d8
Moclobemide-d₈ (Ro111163-d₈) is the deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC₅₀ of 6.061 μM for hMAO-A .Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-14605BS

Rasagiline-13C3 mesylate racemic

Rasagiline- ¹³C₃ (mesylate racemic) is a ¹³C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1]. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W700834

Harman-d3

Harman-d₃ is deuterium labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

HY-W777360

Harman-13C2,15N

Harman- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Harmane. Harmane is a benzodiazepine receptor inhibitor (IC₅₀=7 μM), with IC₅₀ values for mACh, Opioid Receptor, MAO-A/B, and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane also inhibits haloperidol and serotonin, with IC₅₀ values of 163 μM and 101 μM, respectively. Harmane inhibits the I1 imidazoline receptor (IC₅₀=30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) .

Cat. No.	Product Name		Classification

HY-121072

ASS234		Alkynes
ASS234 is a potent monoamino oxidase (MAO) inhibitor with IC₅₀s of 5.2 nM and 43 nM for MAO-A and MAO-B, respectively. ASS234 also inhibits AChE and BuChE with IC₅₀s of 350 nM and 460 nM, respectively .

HY-131036

MAO-IN-M30 dihydrochloride		Alkynes
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible *MAO-A* (IC₅₀=37 nM) and *MAO-B* (IC₅₀=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-A0091

Pargyline hydrochloride 2 Publications Verification		Alkynes
Pargyline hydrochloride is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for *MAO-A* and *MAO-B*, respectively. Pargyline hydrochloride has antihypertensive and anticancer activities . Pargyline (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-A0091A

Pargyline 2 Publications Verification		Alkynes
Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with K_is of 13 μM and 0.5 μM for *MAO-A* and *MAO-B*, respectively. Pargyline has antihypertensive and anticancer activities . Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-146314

MAO-B-IN-9		Alkynes
MAO-B-IN-9 (compound 16) is a potent, selective, BBB-penetrated, irreversible and time-dependent *MAO-B* (monoamine oxidase B) inhibitor, with an IC₅₀ of 0.18 μM. MAO-B-IN-9 prevents Aβ_1-42-induced neuronal cell death. MAO-B-IN-9 shows neuroprotective effects, which may be the result of its Aβ_1-42 anti-aggregation effects . MAO-B-IN-9 is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605

Rasagiline mesylate Maximum Cited Publications 6 Publications Verification (R)-AGN1135 mesylate; TVP1012 mesylate		Alkynes
Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605A

Rasagiline Maximum Cited Publications 6 Publications Verification (R)-AGN1135; TVP1012		Alkynes
Rasagiline (R-AGN1135) is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14200

(S)-Rasagiline 1 Publications Verification TVP1022; S-PAI		Alkynes
(S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible *MAO* inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively . (S)-Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-142706

MAO A/HDAC-IN-1		Alkynes
MAO A/HDAC-IN-1 is a dual?inhibitor?of *monoamine oxidase A (MAO* A) and HDAC*. MAO* A/HDAC-IN-1 can be used for glioma research . MAO A/HDAC-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-146677

5-HT6R/MAO-B modulator 1		Alkynes
5-HT6R/MAO-B modulator 1 (compound 48) is an antagonist of 5-HT₆R at Gs signaling and an irreversible *MAO-B* inhibitor. 5-HT6R/MAO-B modulator 1 exhibits glioprotective properties. 5-HT6R/MAO-B modulator 1 can reverse Scopolamine-induced memory deficits . 5-HT6R/MAO-B modulator 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10399

Ladostigil TV-3326		Alkynes
Ladostigil (TV-3326) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for *MAO-B* and AChE, respectively. Ladostigil exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10399A

Ladostigil hydrochloride TV-3326 hydrochloride		Alkynes
Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for *MAO-B* and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease . Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10400

Ladostigil hemitartrate TV-3326 hemitartrate		Alkynes
Ladostigil (TV-3326) hemitartrate is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC₅₀s of 37.1 and 31.8 μM for *MAO-B* and AChE, respectively. Ladostigil hemitartrate exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil hemitartrate can be used for the research of depression and Alzheimer's disease . Ladostigil (hemitartrate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-119532

Nordeprenyl Desmethylselegiline		Alkynes
Nordeprenyl is the metabolite of Deprenyl. Deprenyl is a potent, selective and irreversible inhibitor of MAO-B . Nordeprenyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14605BS

Rasagiline-13C3 mesylate racemic AGN1135-¹³C₃; TVP1012-¹³C₃ racemic		Alkynes
Rasagiline- ¹³C₃ (mesylate racemic) is a ¹³C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1]. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14197A

Clorgyline hydrochloride 4 Publications Verification		Alkynes
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research, structurally related to Pargyline (HY-A0091A). Clorgyline hydrochloride has little effect on the amounts of conjugated dopamine (DA) present in superfusate of slices from rat striatum. Clorgyline hydrochloride contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

HY-120419

PF9601N		Alkynes
PF9601N, an monoamine oxidase B (MAO-B) inhibitor, possesses neuroprotective properties in several in vitro and in vivo models of Parkinson's disease (PD). PF9601N can be used for the research of neurodegenerative diseases mediated by excitotoxicity . PF9601N is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-145259

HDAC6-IN-3		Alkynes
HDAC6-IN-3 (Compound 14), an antiprostate cancer agent, is a potent, orally active HDAC6 inhibitor with IC₅₀s ranging from 0.02-1.54 μM for HDAC1/2/3/6/8/10. HDAC6-IN-3 is also an effective *MAO-A* (IC₅₀=0.79 μM) and LSD1 inhibitor . HDAC6-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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