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Results for "

Neurotoxicity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (3) Adenosine Deaminase (2) Akt (1) AMPK (3) Amyloid-β (39) Antibiotic (7) Apical Sodium-Dependent Bile Acid Transporter (1) Apoptosis (41) ATP Synthase (3) Autophagy (11) Bacterial (12) Bcl-2 Family (1) Beta-secretase (1) Biochemical Assay Reagents (5) Cannabinoid Receptor (2) Caspase (5) CDK (1) Cholinesterase (ChE) (43) COX (9) CXCR (1) Cytochrome P450 (2) DNA/RNA Synthesis (4) Dopamine Receptor (4) Drug Derivative (3) Drug Intermediate (2) Drug Metabolite (2) EAAT (2) Endogenous Metabolite (41) Epoxide Hydrolase (2) ERK (3) FAAH (1) Ferroptosis (7) Fungal (10) GABA Receptor (5) Glutathione S-transferase (1) Glycosidase (1) GSK-3 (3) HBV (4) HDAC (3) Herbicide (9) Histone Acetyltransferase (1) HIV (3) HSP (2) iGluR (14) Insecticide (14) Interleukin Related (7) Isotope-Labeled Compounds (28) JNK (4) Keap1-Nrf2 (6) Liposome (1) mGluR (1) Microtubule/Tubulin (8) Mitochondrial Metabolism (9) Mitophagy (5) MMP (5) Monoamine Oxidase (4) Monoamine Transporter (1) mTOR (3) Na+/K+ ATPase (7) nAChR (6) NADPH Oxidase (1) NF-κB (2) NO Synthase (1) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (7) Parasite (2) PARP (3) Penicillin-binding protein (PBP) (3) PGE synthase (2) Phosphodiesterase (PDE) (5) PI3K (1) PKC (1) Potassium Channel (3) Prostaglandin Receptor (1) PROTACs (1) Proteasome (2) RAR/RXR (4) Reactive Oxygen Species (ROS) (23) Reference Standards (38) ROS Kinase (1) Sigma Receptor (4) Small Interfering RNA (siRNA) (2) Sodium Channel (4) STAT (2) Steroid Sulfatase (1) Tau Protein (4) TGF-β Receptor (1) TNF Receptor (1) Topoisomerase (3) TRP Channel (1) α-synuclein (4) γ-secretase (2)
By Research Areas:	Cancer (55) Cardiovascular Disease (8) Endocrinology (5) Infection (27) Inflammation/Immunology (42) Metabolic Disease (17) Neurological Disease (212)
Oligonucleotides:	Antioxidants (1) Phospholipids (1) siRNA drugs (2) siRNAs (2)

258

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0663

Talatisamine	Potassium Channel	Neurological Disease
Talatisamine, a aconitum alkaloid, is specific K ⁺ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons .

HY-B0137

Prilocaine 1 Publications Verification	Na+/K+ ATPase	Neurological Disease
Prilocaine, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-N7027

Macrozamin	Others	Neurological Disease Cancer
Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-N7368

Hibifolin	Adenosine Deaminase	Neurological Disease Inflammation/Immunology Cancer
Hibifolin, a flavonol glycoside, is a potential inhibitor of adenosine deaminase (ADA), with a K_i of 49.92 μM. Hibifolin protects neurons against beta-amyloid-induced neurotoxicity .

HY-12535

Trichodesmine	Glutathione S-transferase	Neurological Disease Metabolic Disease
Trichodesmine is a dehydropyrrolizidine alkaloid. Trichodesmine can produces hepatotoxicty, pneumo- and neurotoxicity in vivo .

HY-147382

Neuronotoxicity-IN-1	Drug Derivative	Neurological Disease
Neuronotoxicity-IN-1, a pyridothiazine derivative, is a kainic acid neurotoxicity inhibitor. Neuronotoxicity-IN-1 is a neuroprotective agent .

HY-B0137A

Prilocaine hydrochloride	Na+/K+ ATPase	Neurological Disease
Prilocaine hydrochloride, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-B0137B

Prilocaine acetate	Na+/K+ ATPase	Neurological Disease
Prilocaine acetate, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine acetate has neurotoxic effects .

HY-N8103

Heishuixiecaoline A	Amyloid-β	Neurological Disease
Heishuixiecaoline A is a germacrane-type sesquiterpenoid. Heishuixiecaoline A shows protective effect on the neurotoxicity of PC12 cells induced by Aβ_25-35 .

HY-B0137R

Prilocaine (Standard)	Reference Standards Na+/K+ ATPase	Neurological Disease
Prilocaine (Standard) is the analytical standard of Prilocaine. This product is intended for research and analytical applications. Prilocaine, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-B0137AR

Prilocaine hydrochloride (Standard)	Reference Standards Na+/K+ ATPase	Neurological Disease
Prilocaine (hydrochloride) (Standard) is the analytical standard of Prilocaine (hydrochloride). This product is intended for research and analytical applications. Prilocaine hydrochloride, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-N7027R

Macrozamin (Standard)	Reference Standards Others	Neurological Disease Cancer
Macrozamin (Standard) is the analytical standard of Macrozamin. This product is intended for research and analytical applications. Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-N11930

5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone	Others	Neurological Disease
Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone is a neuroprotective agent . Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cell .

HY-P5854

Aa1 toxin	Potassium Channel	Neurological Disease
Aa1 toxin, a neurotoxic peptide that can be obtained from the venom of Androctonus australis Garzoni, is a specific potassium channel blocker. Aa1 toxin can be used in the study of neurological diseases .

HY-149803A

S1R agonist 1 hydrochloride	Sigma Receptor	Neurological Disease
S1R agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist with K_is of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity .

HY-149804A

S1R agonist 2 hydrochloride	Sigma Receptor	Neurological Disease
S1R agonist 2 (Compound 8b) hydrochloride is a selective S1R agonist with K_is of 1.1 nM and 88 nM for S1R and S2R, respectively. S1R agonist 2 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity .

HY-P5807A

Cn2 toxin TFA β-Mammal toxin Cn2 TFA	Sodium Channel	Neurological Disease
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6 .

HY-B0835

Fenobucarb	Apoptosis	Cardiovascular Disease Neurological Disease
Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals .

HY-N7368R

Hibifolin (Standard)	Reference Standards Adenosine Deaminase	Neurological Disease Inflammation/Immunology Cancer
Hibifolin (Standard) is the analytical standard of Hibifolin. This product is intended for research and analytical applications. Hibifolin, a flavonol glycoside, is a potential inhibitor of adenosine deaminase (ADA), with a Ki of 49.92 μM. Hibifolin protects neurons against beta-amyloid-induced neurotoxicity .

HY-121192

Capillarisin 1 Publications Verification	Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity .

HY-Z0283

Benzamide Benzenecarboxamide; Phenylamide	Endogenous Metabolite PARP	Others
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-146099

GABAA receptor agent 7	GABA Receptor	Neurological Disease
GABAA receptor agent 7 (compoud 5c) is a potent GABAA receptor positive modulator. GABAA receptor agent 7 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 7 has the potential for the research of epilepsy .

HY-146100

GABAA receptor agent 8	GABA Receptor	Neurological Disease
GABAA receptor agent 8 (compoud 5e) is a potent GABAA receptor positive modulator. GABAA receptor agent 8 shows anticonvulsant activity in vitro and in vivo with low neurotoxicity. GABAA receptor agent 8 has the potential for the research of epilepsy .

HY-109116A

Hydromethylthionine dihydrobromide Leukomethylene blue dihydrobromide; LMTM dihydrobromide	Tau Protein	Neurological Disease
Hydromethylthionine dihydrobromide (Leukomethylene blue dihydrobromide) is a potent inhibitor of TAU protein aggregation. Hydromethylthionine dihydrobromide reduces neurodegeneration by interacting with TAU proteins and preventing them from forming neurotoxic aggregates. Hydromethylthionine dihydrobromide can be used in the study of Alzheimer's disease and other TAU related disorders .

HY-B0692A

Cefepime chloride BMY-28142 chloride	Penicillin-binding protein (PBP) Antibiotic Bacterial	Infection Cancer
Cefepime (BMY-28142) chloride is a broad-spectrum and cross the blood-brain barrier cephalosporin. Cefepime chloride shows antibacterial effects against both Gram-positive and Gram-negative aerobic bacteria. Cefepime chloride induces neurotoxicity .

HY-B0692

Cefepime 5+ Cited Publications BMY-28142	Penicillin-binding protein (PBP) Antibiotic Bacterial	Infection Cancer
Cefepime (BMY-28142) is a broad-spectrum and cross the blood-brain barrier cephalosporin. Cefepime shows antibacterial effects against both Gram-positive and Gram-negative aerobic bacteria. Cefepime induces neurotoxicity .

HY-W019870A

Glufosinate	Herbicide	Neurological Disease
Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity .

HY-B0835R

Fenobucarb (Standard)	Reference Standards Apoptosis	Cardiovascular Disease Neurological Disease
Fenobucarb (Standard) is the analytical standard of Fenobucarb. This product is intended for research and analytical applications. Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis. Fenobucarb is a possible risk factor to cardiovascular and cerebrovascular systems in animals .

HY-Z0283R

Benzamide (Standard) Benzenecarboxamide (Standard); Phenylamide (Standard)	Reference Standards Endogenous Metabolite PARP	Others
Benzamide (Standard) is the analytical standard of Benzamide. This product is intended for research and analytical applications. Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-W585874

Nε-(Carboxyethyl)lysine	EAAT	Neurological Disease
Nε-(Carboxyethyl)lysine is an advanced glycation end product (AGE). Nε-(Carboxyethyl)lysine causes cross-linking between proteins, affects the structure and function of proteins, and leads to protein denaturation. Nε-(Carboxyethyl)lysine binds to RAGE receptors, affects cell signaling, regulates processes such as inflammatory response, cell proliferation and apoptosis. Nε-(Carboxyethyl)lysine affects glutamate transporter, reduces glutamate uptake and S100B protein secretion, affects neurotransmission in the nervous system, and exhibits diabetic-related neurotoxicity .

HY-W019870

Glufosinate ammonium 1 Publications Verification	Herbicide	Neurological Disease
Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity .

HY-B0835S

Fenobucarb-d3	Isotope-Labeled Compounds Apoptosis	Neurological Disease
Fenobucarb-d₃ is the deuterium labeled Fenobucarb. Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis .

HY-N12622

AChE-IN-58	Cholinesterase (ChE)	Neurological Disease
AChE-IN-58 (Compound 3) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-58 can extend the mean lifespan, delay the Aβ₁-42-induced paralysis, enhanc the locomotion, and alleviate glutamic acid (Glu)-induced neurotoxicity of CL4176 worms .

HY-138903

L-Homocysteic acid L-HCA	iGluR	Neurological Disease
L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC₅₀: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders .

HY-B1945

DEHP 2 Publications Verification Bis(2-ethylhexyl) phthalate; Ergoplast FDO; ESBO-D 82	Endogenous Metabolite	Metabolic Disease
DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity .

HY-B0692R

Cefepime (Standard) BMY-28142 (Standard)	Penicillin-binding protein (PBP) Reference Standards Antibiotic Bacterial	Infection Cancer
Cefepime (Standard) is the analytical standard of Cefepime. This product is intended for research and analytical applications. Cefepime (BMY-28142) is a broad-spectrum and cross the blood-brain barrier cephalosporin. Cefepime shows antibacterial effects against both Gram-positive and Gram-negative aerobic bacteria. Cefepime induces neurotoxicity .

HY-W013058

Decabromodiphenyl ethane DBDPE; 1,2-Bis(perbromophenyl)ethane	Biochemical Assay Reagents	Neurological Disease Metabolic Disease
Decabromodiphenyl ethane (DBDPE; 1,2-Bis(perbromophenyl)ethane) is a brominated flame retardant. Decabromodiphenyl ethane can exhibit neurotoxicity, thyroid toxicity, reproductive developmental toxicity, hepatotoxicity, and oxidative stress in living organisms .

HY-176065

Nav1.2-IN-1	Sodium Channel	Neurological Disease
Nav1.2-IN-1 (compound 5i), a 3-(1,2,3,6-tetrahydropyridine)-4-azaindole derivative, is a potent and selective Nav1.2 inhibitor. Nav1.2-IN-1 induces a reduction in the peak amplitude of Nav1.2 currents with an IC₅₀ value of 7.79 μM. Nav1.2-IN-1 exhibits antiepileptic activity. Nav1.2-IN-1 shows high anticonvulsant effect and low neurotoxicity in subcutaneous Pentetrazole (sc-PTZ)-induced epilepsy mode .

HY-147863

HBV-IN-24	HBV	Infection Neurological Disease
HBV-IN-24 (compound (2ʹS, 6S)-1a) is a potent HBV inhibitor. HBV-IN-24 exhibits potent inhibition activity against HBV DNA, HBsAg, and HBeAg, with EC₅₀ values of 0.6, 0.6, and 4.6 nM, respectively. HBV-IN-24 shows excellent antiviral activity, could have improved neurotoxicity .

HY-W008719

MPP+ iodide 10+ Cited Publications	Mitochondrial Metabolism	Neurological Disease
MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .

HY-W019870R

Glufosinate ammonium (Standard)	Herbicide Reference Standards	Neurological Disease
Glufosinate (ammonium) (Standard) is the analytical standard of Glufosinate (ammonium). This product is intended for research and analytical applications. Glufosinate ammonium, a phosphinic acid analogue of glutamic acid, is an herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium exerts neurotoxic activity .

HY-B1945R

DEHP (Standard) Bis(2-ethylhexyl) phthalate (Standard); Ergoplast FDO (Standard); ESBO-D 82 (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
DEHP (Standard) is the analytical standard of DEHP. This product is intended for research and analytical applications. DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity .

HY-148717

NSC363998 free base	Others	Neurological Disease
NSC363998 (free base) is an orally active compound. NSC363998 (free base) can suppress rCGG90 induced neurotoxicity. NSC363998 (free base) can be used for the research of neurodegenerative disorder such as Fragile X associated tremor/ataxia syndrome (FXTAS) .

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Endogenous Metabolite	Neurological Disease
4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .

HY-B1066

Butylhydroxyanisole 5 Publications Verification Butylated hydroxyanisole; E320	Reactive Oxygen Species (ROS) Ferroptosis	Neurological Disease Inflammation/Immunology
Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a ferroptosis inducer .

HY-152171

GZ-11608	Monoamine Transporter	Neurological Disease
GZ-11608 is a potent and selective vesicular monoamine transporter-2 (VMAT2) inhibitor with high affinity (Ki = 25 nM). GZ-11608 decreases methamphetamine-induced dopamine release from isolated synaptic vesicles from brain dopaminergic neurons. GZ-11608 exhibits rapid brain penetration and without neurotoxicity. GZ-11608 can be used for the research of methamphetamine use disorder .

HY-14533

K 01-162 K162	Amyloid-β	Neurological Disease
K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ₄₂ peptide with an EC₅₀ value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease .

HY-N3562

Cedrin	Reactive Oxygen Species (ROS)	Neurological Disease
Cedrin is a natural flavonoid that can be found in Cedrus deodara. Cedrin protects PC12 cells against neurotoxicity induced by Aβ1-42. Cedrin can reduce reactive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content .

HY-116377

DU-14	Steroid Sulfatase	Neurological Disease
DU-14 is a potent steroid sulfatase inhibitor with an IC₅₀ of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC₅₀ = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity .

HY-101448

TMI-1 WAY-171318	MMP Apoptosis Interleukin Related TNF Receptor Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) (IC₅₀ of 8.4 nM), ADAM-TS-4, ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors (TNF-α、IL-1β、IL-6) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions .

Cat. No.	Product Name	Type

HY-W127493

1-Hexacosanol Ceryl Alcohol	Cell Assay Reagents
1-Hexacosanol is a compound in the bioactive fraction of plant extracts that mediates insecticidal activity. 1-Hexacosanol has larvicidal activity and can inhibit the acetylcholinesterase activity of Culex quinquefasciatus, Aedes aegypti and Chironomus riparius, exerting neurotoxic effects .

HY-109521A

Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT)

Manganese(Ⅱ) chloride (tetrahydrate), molecular biology grade,≥99.0% (KT)

Buffer Reagents

Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) is an orally active and a blood-brain barrier penetrant compound. It affects the activities of multiple enzymes in cells, such as regulating the activities of histone acetyltransferase (HAT) and histone deacetylase (HDAC), thereby affecting gene expression. It has multiple activities such as neurotoxicity, embryotoxicity, and reproductive toxicity. It is currently mainly used in neurodegenerative diseases and toxicology research.

HY-W127493R

1-Hexacosanol (Standard)

Ceryl Alcohol (Standard)

Cell Assay Reagents

1-Hexacosanol (Standard) is the analytical standard of 1-Hexacosanol. This product is intended for research and analytical applications. 1-Hexacosanol is a compound in the bioactive fraction of plant extracts that mediates insecticidal activity. 1-Hexacosanol has larvicidal activity and can inhibit the acetylcholinesterase activity of Culex quinquefasciatus, Aedes aegypti and Chironomus riparius, exerting neurotoxic effects .

Cat. No.	Product Name	Target	Research Area

HY-P5807A

Cn2 toxin TFA β-Mammal toxin Cn2 TFA	Sodium Channel	Neurological Disease
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide that is the main toxin in scorpion venom. Cn2 toxin (TFA) specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6 .

HY-138903

L-Homocysteic acid L-HCA	iGluR	Neurological Disease
L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as a NMDA receptor agonist (EC₅₀: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders .

HY-P1517

β-Amyloid (31-35)	Amyloid-β	Neurological Disease
β-Amyloid (31-35) is the shortest sequence of native Amyloid-β peptide that retains neurotoxic activity.

HY-P0128

β-Amyloid (25-35) 25+ Cited Publications Amyloid beta-peptide (25-35); Aβ25-35; β-Amyloid peptide (25-35)	Amyloid-β	Neurological Disease
β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells .

HY-P1061

Colivelin Maximum Cited Publications 58 Publications Verification	STAT Amyloid-β	Neurological Disease
Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3?in vitro . Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin has the potential for the treatment of alzheimer's disease and ischemic brain injury

HY-P1061A

Colivelin TFA Maximum Cited Publications 58 Publications Verification	STAT Amyloid-β Apoptosis	Neurological Disease
Colivelin TFA is a brain penetrant neuroprotective peptide and a potent activator of STAT3, suppresses neuronal death by activating STAT3 in vitro . Colivelin TFA exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease . Colivelin TFA has the potential for the treatment of alzheimer's disease and ischemic brain injury .

HY-105066

Davunetide 1 Publications Verification	Microtubule/Tubulin Amyloid-β	Neurological Disease
Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity .

HY-P5854

Aa1 toxin	Potassium Channel	Neurological Disease
Aa1 toxin, a neurotoxic peptide that can be obtained from the venom of Androctonus australis Garzoni, is a specific potassium channel blocker. Aa1 toxin can be used in the study of neurological diseases .

HY-P10035

β Amyloid(28-35) human	Amyloid-β	Neurological Disease
β Amyloid(28-35) human is a β-amyloid peptide (Abeta), a lipid-induced amyloid core fragment. β Amyloid oligomers are neurotoxic, and β Amyloid(28-35) human can interact with neuronal membranes, regulate secondary structure and neurotoxicity, and cause Alzheimer's disease. β Amyloid(28-35) human has anisotropic effects on the acidic phospholipid DPH, resulting in enhanced internal fluidity of lipid membrane bilayers .

HY-P3275

β-Amyloid (17-40) Aβ(17-40)	Amyloid-β	Neurological Disease
β-Amyloid (17-40) (Aβ(17-40)) is a fragment of Amyloid-β peptide that has shown neurotoxic activities in SH-SY5Y and IMR-32 cells. β-Amyloid (17-40) can be used for the research of neurological disease .

HY-P1363B

β-Amyloid (1-42), human, HFIP-treated 10+ Cited Publications	Amyloid-β	Neurological Disease
β-Amyloid (1-42), human, HFIP-treated, a 42-amino acid peptide that has been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human, HFIP-treated remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, HFIP-treated, after being dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 ℃, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 ℃ to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P1928

Humanin	Bcl-2 Family	Neurological Disease Endocrinology
Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging . Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG .

HY-P0128A

β-Amyloid (25-35), HFIP-treated Amyloid beta-peptide (25-35), HFIP-treated; Aβ25-35, HFIP-treated; β-Amyloid peptide (25-35), HFIP-treated	Amyloid-β	Neurological Disease
β-Amyloid (25-35) (Amyloid beta-peptide (25-35)), HFIP-treated is a β-Amyloid (25-35) (HY-P0128) treated with HFIP. β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, has shown neurotoxic activities in cultured cells .

HY-P1363

β-Amyloid (1-42), human TFA 10+ Cited Publications Amyloid β-peptide (1-42) (human) TFA	Amyloid-β	Neurological Disease
β-Amyloid (1-42) (Amyloid β-peptide (1-42), human TFA, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human TFA remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human TFA, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 ℃, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 ℃ to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P1363A

β-Amyloid (1-42), human 10+ Cited Publications Amyloid β-peptide (1-42) (human)	Amyloid-β	Neurological Disease
β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 ℃, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 ℃ to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P1508A

Bactenecin TFA Bactenecin, bovine TFA	Bacterial Fungal	Infection
Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-P1508

Bactenecin Bactenecin, bovine	Bacterial Fungal Antibiotic	Infection
Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0663

Talatisamine	Alkaloids Pyrrole Alkaloids Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Potassium Channel
Talatisamine, a aconitum alkaloid, is specific K ⁺ channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons .

HY-N7027

Macrozamin	Structural Classification Liliaceae Source classification Smilacis Glabrae Rhizoma Plants Saccharides	Others
Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-N7368

Hibifolin	Flavonols Structural Classification Flavonoids other families Neurological Disease Classification of Application Fields Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Adenosine Deaminase
Hibifolin, a flavonol glycoside, is a potential inhibitor of adenosine deaminase (ADA), with a K_i of 49.92 μM. Hibifolin protects neurons against beta-amyloid-induced neurotoxicity .

HY-121192

Capillarisin 1 Publications Verification	Flavonoids Flavones Source classification Phenols Polyphenols Plants Compositae Artemisia capillaris Thunb.	Reactive Oxygen Species (ROS)
Capillarisin, as a constituent from Artemisiae Capillaris herba, is found to exert anti-inflammatory and antioxidant properties. Capillarisin can be used for the research of asthma-mediated complications and can be a potential neuroprotectant against bupivacaine-induced neurotoxicity .

HY-Z0283

Benzamide Benzenecarboxamide; Phenylamide	Structural Classification Alkaloids Human Gut Microbiota Metabolites Classification of Application Fields Other Alkaloids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite PARP
Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-12535

Trichodesmine	Alkaloids Structural Classification other families Pyrrole Alkaloids Source classification Plants	Glutathione S-transferase
Trichodesmine is a dehydropyrrolizidine alkaloid. Trichodesmine can produces hepatotoxicty, pneumo- and neurotoxicity in vivo .

HY-N8103

Heishuixiecaoline A	Structural Classification Terpenoids Sesquiterpenes Source classification Valeriana amurensis Smir. ex Komarov Plants Valerianaceae	Amyloid-β
Heishuixiecaoline A is a germacrane-type sesquiterpenoid. Heishuixiecaoline A shows protective effect on the neurotoxicity of PC12 cells induced by Aβ_25-35 .

HY-N7027R

Macrozamin (Standard)	Structural Classification Liliaceae Source classification Smilacis Glabrae Rhizoma Plants Saccharides	Reference Standards Others
Macrozamin (Standard) is the analytical standard of Macrozamin. This product is intended for research and analytical applications. Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-N11930

5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone	Structural Classification Gramineae Source classification Phenols Polyphenols Plants Imperata cylindrica (L.) Beauv.	Others
Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone is a neuroprotective agent . Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cell .

HY-N7368R

Hibifolin (Standard)	Flavonols Structural Classification Flavonoids other families Source classification Phenols Polyphenols Plants	Reference Standards Adenosine Deaminase
Hibifolin (Standard) is the analytical standard of Hibifolin. This product is intended for research and analytical applications. Hibifolin, a flavonol glycoside, is a potential inhibitor of adenosine deaminase (ADA), with a Ki of 49.92 μM. Hibifolin protects neurons against beta-amyloid-induced neurotoxicity .

HY-W019870A

Glufosinate	Microorganisms Source classification	Herbicide
Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity .

HY-Z0283R

Benzamide (Standard) Benzenecarboxamide (Standard); Phenylamide (Standard)	Structural Classification Alkaloids Human Gut Microbiota Metabolites Other Alkaloids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite PARP
Benzamide (Standard) is the analytical standard of Benzamide. This product is intended for research and analytical applications. Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-N12622

AChE-IN-58	Structural Classification Flavonoids Flavones Source classification Camellia sinensis (L.) O. Ktze. Plants Theaceae	Cholinesterase (ChE)
AChE-IN-58 (Compound 3) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-58 can extend the mean lifespan, delay the Aβ₁-42-induced paralysis, enhanc the locomotion, and alleviate glutamic acid (Glu)-induced neurotoxicity of CL4176 worms .

HY-B1945

DEHP 2 Publications Verification Bis(2-ethylhexyl) phthalate; Ergoplast FDO; ESBO-D 82	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity .

HY-B1945R

DEHP (Standard) Bis(2-ethylhexyl) phthalate (Standard); Ergoplast FDO (Standard); ESBO-D 82 (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
DEHP (Standard) is the analytical standard of DEHP. This product is intended for research and analytical applications. DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity .

HY-W009300

4-Hydroxyestrone 1 Publications Verification 4-OHE1	Structural Classification Natural Products Animals Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .

HY-N3562

Cedrin	Structural Classification Cedrus deodara (Roxburgh) G. Don Flavonoids Neurological Disease Classification of Application Fields Pinaceae Flavonones Source classification Plants Disease Research Fields	Reactive Oxygen Species (ROS)
Cedrin is a natural flavonoid that can be found in Cedrus deodara. Cedrin protects PC12 cells against neurotoxicity induced by Aβ1-42. Cedrin can reduce reactive oxygen species overproduction, increase the activity of superoxide dismutase and decrease malondialdehyde content .

HY-B1777A

Spermine tetrahydrochloride 4 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .

HY-B1777

Spermine 4 Publications Verification NSC 268508; Neuridine	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Bacterial Reactive Oxygen Species (ROS) DNA/RNA Synthesis
Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro .

HY-N3686

D-Arabitol	Structural Classification Microorganisms Source classification Endogenous metabolite Saccharides	Endogenous Metabolite
D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in human.

HY-N7780

Aflatrem	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
Aflatrem is a mycotoxin that can be isolated from Aspergillus flavus. Aflatrem has acute neurotoxic effects and can be ued in neurological disease .

HY-N3686R

D-Arabitol (Standard)	Structural Classification Microorganisms Source classification Endogenous metabolite Saccharides	Reference Standards Endogenous Metabolite
D-Arabitol (Standard) is the analytical standard of D-Arabitol. This product is intended for research and analytical applications. D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in human.

HY-100801R

L-threo-3-Hydroxyaspartic acid (Standard)	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	EAAT Reference Standards
Prilocaine (hydrochloride) (Standard) is the analytical standard of Prilocaine (hydrochloride). This product is intended for research and analytical applications. Prilocaine hydrochloride, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-10448

Capsaicin 45+ Cited Publications (E)-Capsaicin	Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Source classification Phenols Solanaceae Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	TRP Channel Autophagy Apoptosis Endogenous Metabolite
Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain-relieving, antioxidant, anti-inflammatory, anti-cancer and certain neurotoxic effects .

HY-N3117

Paeonilactone B (+)-Paeonilactone B	Structural Classification Natural Products Paeonia lactiflora Pall. Source classification Plants Paeoniaceae	Others
Paeonilactone B is a monoterpene with neuroprotective effect against oxidative stress. Paeonilactone B protects rat cortical cells against H₂O₂-induced neurotoxicity .

HY-N13742

Dihydrohonokiol B Dihydrohonokiol	Structural Classification Magnoliaceae Source classification Phenols Polyphenols Plants Magnolia denudata Desr.	GABA Receptor
Dihydrohonokiol B (Dihydrohonokiol) is an anxiolytic agent. Dihydrohonokiol B can reduce the neurotoxicity induced by amyloid β protein by stimulating the GABA_C receptor. Dihydrohonokiol B can be used in the research of neurodegenerative diseases such as Alzheimer's disease .

HY-N7745

Glucosylsphingosine 1 Publications Verification Glucopsychosine; Lyso-Gb1; Lyso-GL1	Structural Classification Animals Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides	Drug Metabolite Glycosidase
Glucosylsphingosine (lyso-Gb1) is a deacylated form of glucosylceramide with neurotoxicity and is also a noncompetitively inhibitor of glucocerebrosidase with a K_i value of 30 μM. Glucosylsphingosine is promising for research of Krabbe and Gaucher disease .

HY-N8730

7,8,3′,4′-Tetramethoxyflavone	Structural Classification Flavonoids Punica granatum L. Flavones Source classification Punicaceae Plants	Others
7,8,3 ',4 '-Tetramethoxyflavone is an extract isolated from natural pomegranate juice and seeds. 7,8,3 ',4' -Tetramethoxyflavone has a protective effect on the neurotoxicity of paraquat-induced Parkinson's disease mouse model .

HY-B0770

Artemotil 1 Publications Verification β-Arteether; (+)-Arteether; Arteether	Structural Classification Natural Products Classification of Application Fields Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Cancer	CXCR Parasite
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant *Plasmodium falciparum* malaria with an IC₅₀ of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

HY-N0568R

Madecassoside (Standard) Asiaticoside A (Standard)	Triterpenes Structural Classification Terpenoids Source classification Tagetes lucida Cav. Umbelliferae Plants Endogenous metabolite	Reference Standards Endogenous Metabolite Apoptosis Autophagy Keap1-Nrf2 p38 MAPK Caspase
Madecassoside (Standard) is the analytical standard of Madecassoside. This product is intended for research and analytical applications. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects. Madecassoside is a pentacyclic triterpene isolated from Centella asiatica. Madecassoside is orally active and has inhibitory properties against inflammation, oxidation, apoptosis and autophagy. Madecassosid inhibits activities of p38 MAPK and NF-kB , exhibits an anti-apopototic property, activates Nrf2 expression to reduce the neurotoxicity[10]. Madecassoside can be used in endocrine diseases, cardiovascular diseases, skin diseases and other diseases.

HY-N6032

Esculentoside B Phytolaccoside B	Source classification Plants Phytolacca americana L. Phytolaccaceae	Cholinesterase (ChE) JNK NF-κB Fungal
Esculentoside B (Phytolaccoside B) is a natural product from the roots of Phytolacca acinosa Roxb. Esculentoside B is neurotoxic to zebrafish larvae, and impairs their central nervous system development. Esculentoside B inhibits inflammatory response and has antifungal activity .

HY-N2166

Tomatine α-Tomatine; Lycopersicin; Tomatin	Structural Classification Source classification Solanum lycopersicum L. Solanaceae Plants Steroids	Proteasome Apoptosis
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity .

HY-N9257

8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside	Structural Classification Polysaccharides Source classification Plants Valerianaceae Valeriana amurensis Smir. ex Komarov Saccharides	Others
8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside (Compound 7) is a compound derived from roots and rhizomes. 8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside could prevent neurotoxicity in PC12 cells .

HY-138800

Spinosad 3 Publications Verification	Structural Classification Natural Products Microorganisms Neurological Disease Classification of Application Fields Source classification Disease Research Fields Biological Pesticide Research Agricultural Research	nAChR
Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Spinosad has an excellent environmental and mammalian toxicological profile. Larvicidal activity .

HY-N6776

Penitrem A	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Potassium Channel
Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals .

HY-100808

D-Serine 1 Publications Verification (R)-Serine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Amino acids Endogenous metabolite	iGluR Endogenous Metabolite
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .

HY-N9602

6,7,4'-Trihydroxyflavanone	Structural Classification Flavonoids Dalbergia odorifera T. Chen Leguminosae Flavonones Source classification Plants	Others
6,7,4'-Trihydroxyflavanone is a compound with multiple pharmacological activities, including anti-rheumatic, anti-ischemic, anti-inflammatory, anti-osteoclastogenic and protective T-cells from METH-induced deactivation. 6,7,4'-Trihydroxyflavanone has shown potential protective effects in neurotoxicity studies and can be used to inhibit patients with neurodegenerative diseases caused by METH. 6,7,4'-Trihydroxyflavanone inhibits METH-induced neurotoxicity by upregulating the Nrf2/HO-1 and PI3K/Akt/mTOR signaling pathways. 6,7,4'-Trihydroxyflavanone can also induce Nrf2 nuclear translocation and HO-1 expression, further enhancing its protective effect on neuronal cells .

HY-131592

Tricetin 1 Publications Verification	Flavonols Structural Classification Flavonoids Cupressaceae Thuja occidentalisLinn. Neurological Disease Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Apoptosis Keap1-Nrf2
Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway .

HY-N0061

Ethyl ferulate 1 Publications Verification	Structural Classification Monophenols Simple Phenylpropanols Source classification Phenols Dicerothamnus rhinocerotis Phenylpropanoids Umbelliferae Plants	Reactive Oxygen Species (ROS)
Ethyl ferulate, a naturally lipophilic derivative of ferulic acid originally derived from Rhizoma Chuanxiong, induces heme oxygenase-1 (HO-1) and protects rat neurons against oxidative stress . Ethyl ferulate also protects neurons against amyloid β peptide (1-42)-induced oxidative stress and neurotoxicity .

HY-167843

Alborixin	Structural Classification Microorganisms Antibiotics Source classification	Akt PI3K Autophagy
Alborixin is an inhibitor of the PI3K-AKT pathway that induces autophagy. It promotes the clearance of intracellular and extracellular amyloid-β by upregulating autophagy-related proteins (such as BECN1, ATG5, ATG7) and enhancing lysosomal activity, thereby reducing amyloid-β-mediated neurotoxicity. Alborixin shows potential for research in Alzheimer's disease .

HY-N12123

Peimisine 3-O-β-D-glucopyranoside	Structural Classification Alkaloids Liliaceae Other Alkaloids Source classification Plants Fritillaria unibracteata Hsiao et K. C. Hsia	Others
Peimisine 3-O-β-D-glucopyranoside (Compound 1) is a steroid alkaloid. Peimisine 3-O-β-D-glucopyranoside can be isolated and purified from natural Fritillaria unibracteata. Peimisine 3-O-β-D-glucopyranoside shows moderate protective effect on rotenone-induced neurotoxicity of PC12 cell line .

HY-155534

17β-HSD10-IN-1	Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
17β-HSD10-IN-1 (compound 9) is an orally active inhibitor of 17β-hydroxysteroid dehydrogenase type 10 (17β-HSD10) with blood-brain permeability. 17β-HSD10-IN-1 doesn't result additional effects for mitochondrial off-targets and cytotoxic or neurotoxic effects .

HY-Y1117

Melamine 1 Publications Verification	Structural Classification Natural Products Zea mays L. Classification of Application Fields Gramineae Other Diseases Plants Disease Research Fields	Apoptosis TGF-β Receptor NF-κB COX NADPH Oxidase ROS Kinase
Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models .

HY-100808R

D-Serine (Standard) (R)-Serine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Amino acids Endogenous metabolite	Reference Standards iGluR Endogenous Metabolite
D-Serine (Standard) is the analytical standard of D-Serine. This product is intended for research and analytical applications. D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].

HY-113468A

3-O-Methyldopa 1 Publications Verification 3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Drug Derivative Interleukin Related
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease .

HY-14608AR

L-Glutamic acid monosodium salt (Standard)	Structural Classification Microorganisms other families Animals Source classification Amino acids Plants	Reference Standards iGluR Apoptosis Ferroptosis Endogenous Metabolite
L-Glutamic acid (monosodium salt) (Standard) is the analytical standard of L-Glutamic acid (monosodium salt). This product is intended for research and analytical applications. L-Glutamic acid monosodium salt is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid monosodium salt has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid monosodium salt can be used in the study of neurological diseases .

HY-14608R

L-Glutamic acid (Standard)	Structural Classification Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	Reference Standards Endogenous Metabolite iGluR Ferroptosis Apoptosis
L-Glutamic acid (Standard) is the analytical standard of L-Glutamic acid. This product is intended for research and analytical applications. L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases . IC₅₀ & Target:DA . In Vitro: L-Glutamic acid (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus . L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma . In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice . L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats .

HY-P1508A

Bactenecin TFA Bactenecin, bovine TFA	Infection Natural Products Classification of Application Fields Animals Source classification Disease Research Fields	Bacterial Fungal
Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-P1508

Bactenecin Bactenecin, bovine	Infection Structural Classification Animals Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	Bacterial Fungal Antibiotic
Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei* .

HY-14608

L-Glutamic acid 5+ Cited Publications	Structural Classification Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer	Endogenous Metabolite iGluR Ferroptosis Apoptosis
L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors .

Cat. No.	Product Name	Chemical Structure

HY-B0137AS

Prilocaine-d7 hydrochloride
Prilocaine-d₇ (hydrochloride) is deuterium labeled Prilocaine (hydrochloride). Prilocaine hydrochloride, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-B0835S

Fenobucarb-d3
Fenobucarb-d₃ is the deuterium labeled Fenobucarb. Fenobucarb is a carbamate insecticide. Fenobucarb induces zebrafish developmental neurotoxicity through pathways involved in inflammation, oxidative stress, degeneration and apoptosis .

HY-N3686S

D-Arabitol-13C
D-Arabitol- ¹³C is the ¹³C labeled D-Arabitol. D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in hu .

HY-W711807

D-Arabitol-d7
D-Arabitol-d₇ is the deuterium labeled D-Arabitol (HY-N3686). D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in human.

HY-N3686S1

D-Arabitol-13C-1
D-Arabitol- ¹³C-1 is the ¹³C labeled D-Arabitol. D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in hu .

HY-N3686S2

D-Arabitol-13C-2
D-Arabitol- ¹³C-2 is the ¹³C labeled D-Arabitol. D-Arabitol is a polyol and its accumulation may cause a neurotoxic effect in hu .

HY-W753485

Profenofos-d3
Profenofos-d₃ is the deuterium labeled Profenofos (HY-B0832). Profenofos is an insecticida used on field crops, vegetables, and fruit crops. Profenofos is an acetylcholinesterase (AChE) inhibitor, with neurotoxicity .

HY-B1971S

Deltamethrin-d5
Deltamethrin-d₅ is the deuterium labeled Deltamethrin. Deltamethrin (Decamethrin), a neurotoxic pyrethroid insecticide, produces a reversible sequence of motor symptoms in rats involving hind limb rigidity and choreoathetosis .

HY-W704786

Prilocaine Hydrochloride-d7
Prilocaine Hydrochloride-d₇ is the deuterium labeled Prilocaine hydrochloride (HY-B0137A). Prilocaine hydrochloride, an amino amide, is a Na/K-ATPase inhibitor. Prilocaine has neurotoxic effects .

HY-B1315S1

Carbaryl-d7
Carbaryl-d₇ is the deuterium labeled Carbaryl (HY-B1315). Carbaryl is the inhibitor for acetylcholinesterase that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide .

HY-B1315S

Carbaryl-d3
Carbaryl-d₃ is the deuterium labeled Carbaryl (HY-B1315). Carbaryl is the inhibitor for acetylcholinesterase that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide . X

HY-B0034S

Donepezil-d5 hydrochloride
Donepezil-d₅ (hydrochloride) is deuterium labeled Donepezil (Hydrochloride). Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-B0034S1

Donepezil-d4 hydrochloride
Donepezil-d₄ (hydrochloride) is the deuterium labeled Donepezil hydrochloride. Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC₅₀ of 6.7 nM for AChE activity. Donepezil shows high selectivity for AChE over BuChE . Donepezil exhibits neuroprotective effect on Aβ42 neurotoxicity .

HY-107116S

MAP4343-d4
MAP4343-d₄ is the deuterium labeled MAP4343. MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents .

HY-B0815S

Chlorpyrifos-d10

Chlorpyrifos-d₁₀ is the deuterium labeled Chlorpyrifos. Chlorpyrifos is an organophosphate insecticide that is classified as a phosphorothionate. The oxon metabolite of Chlorpyrifos is an inhibitor of acetylcholinesterase (AChE), affecting neurological function in insects, humans, and other animals. The Chlorpyrifos oxon (CPO) metabolite is hydrolyzed by the plasma enzyme paraoxonase 1 (PON1), and susceptibility to neurotoxicity associated with CPO exposure is mitigated by PON1 overexpression.

HY-114899S

Azamethiphos-d6
Azamethiphos-d₆ is deuterated labeled Azamethiphos (HY-114899). Azamethiphos is an organophosphate insecticide that inhibits AChE. Azamethiphos inhibits sea lice .

HY-B0763S1

Ibudilast-d7

Ibudilast-d₇ is the deuterium labeled Ibudilast. Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .

HY-B0763S

Ibudilast-d3

Ibudilast-d₃ (KC-404-d₃) is the deuterium labeled Ibudilast. Ibudilast (KC-404) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .

HY-W711852

Benzamide-d5

Benzamide-d₅ (Benzenecarboxamide-d₅) is deuterium labeled Benzamide. Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature .

HY-W008719S

MPP+-d3(iodide)

MPP+-d₃ (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT) .

HY-B0763S2

Ibudilast-d7-1

Ibudilast-d₇-1 is the deuterium labeled Ibudilast . Ibudilast (KC-404;AV-411;MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .

HY-100808S

D-Serine-d3

D-Serine-d₃ ((R)-Serine-d₃) is a deuterium labeled D-Serine (HY-100808). D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration .

HY-B2050S

Trifluralin-d14

Trifluralin-d₁₄ is the deuterium labeled Trifluralin. Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic .

HY-W758421

Diquat-d8 dibromide

Diquat-d₈ dibromide is a deuterium labeled Diquat dibromide (HY-122984). Diquat dibromide is a comprehensive herbicide. Diquat dibromide increases the production of ROS and triggers mitochondrial Autophagy. Diquat dibromide generates free radicals such as superoxide anions through redox cycles, which induce oxidative stress. Diquat dibromide is cytotoxic, reproductive, and neurotoxic. Diquat dibromide is used in cotton, soybean, and other crops to combat noxious weeds .

HY-W009300S1

4-Hydroxyestrone-13C6
4-Hydroxyestrone- ¹³C₆ is a ¹³C-labeled 4-Hydroxyestrone (HY-W009300). 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity .

HY-118504S

Sulfoxaflor-d3

Sulfoxaflor-d₃ is the deuterium labeled Sulfoxaflor (HY-118504). Sulfoxaflor is an orally active full agonist of insect nicotinic acetylcholine receptors (nAChRs), targeting the α-bungarotoxin-insensitive nAChR1 and nAChR2 subtypes. Sulfoxaflor binding to nACh is not inhibited by d-Tubocurarine (HY-125901), but is partially inhibited by Mecamylamine (HY-B1395A). Sulfoxaflor induces inward currents by activating nAChRs, leading to insect neurotoxicity. Sulfoxaflor can be used in the research of agricultural pest control, pesticide toxicology, insect neural receptor pharmacology, etc .

HY-W777283

Idebenone-13C,d3

Idebenone- ¹³C,d₃ is the deuterium labeled and ¹³C-labeled Idebenone (HY-N0303). Idebenone, a well-appreciated mitochondrial protectant, exhibits protective efficacy against neurotoxicity and can be used for the research of Alzheimer's disease, Huntington's disease. Idebenone (oxidised form) has a dose-dependent inhibitory effect on the enzymatic metabolism of arachidonic acid in astroglial homogenates (IC₅₀=16.65 μM) . Idebenone, a coenzyme Q10 analog and an antioxidant, induces apoptotic cell death in the human dopaminergic neuroblastoma SHSY-5Y cells . Idebenone quickly crosses the blood-brain barrier.

HY-W707693

Scyllo-Inositol-d6

Scyllo-Inositol-d₆ is the deuterium labeled Scyllo-Inositol (HY-W010041). Scyllo-Inositol is an inhibitor that targets the aggregation of misfolded proteins (such as α-synuclein and Amyloid-β), is orally effective, and can cross the blood-brain barrier. Scyllo-Inositol can selectively bind to and stabilize non-toxic oligomers, preventing them from converting into toxic fibers, exerting protein homeostasis regulation and neuroprotective activity. Scyllo-Inositol binds to the hydrophobic region of pathogenic proteins, inhibits protein aggregation, and promotes lysosome- and proteasome-mediated degradation pathways, thereby reducing neurotoxicity. Scyllo-Inositol can be used in the study of neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, and Huntington's disease .

HY-B1777AS

Spermine-d8 tetrahydrochloride

Spermine-d₈ (tetrahydrochloride) is the deuterium labeled Spermine tetrahydrochloride. Spermine tetrahydrochloride is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine tetrahydrochloride occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine tetrahydrochloride inhibits primary human embryo lung fibroblasts in vitro. Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine induces neurotoxicity in the striarum dose-dependently. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells .

HY-B0916S

Propoxur-d3

Propoxur-d₃ is the deuterated form of Propoxur (HY-B0916). Propoxur is a reversible, competitive, orally active AChE inhibitor that can cross the blood-brain barrier. Propoxur inhibits AChE activity to induce neurotoxicity, while promoting MMP-2 expression and enhancing tumor cell migration and invasion by inducing intracellular ROS generation and activating the ERK/Nrf2 signaling pathway. On the one hand, Propoxur inhibits AChE, leading to acetylcholine accumulation and causing neurological dysfunction; on the other hand, it promotes Nrf2 nuclear translocation through ROS-dependent ERK1/2 phosphorylation, and upregulates MMP-2 and other invasion-related proteins. Propoxur is also a carbamate insecticide used to combat turf, forestry, and household pests .

HY-N7046S

Silybin B-d3

Silybin B-d₃ (Silibinin B-d₃) is a deuterated Silybin B (HY-N7046). Silybin B (Silibinin B) is an orally active amyloid-β aggregation inhibitor and ATR pathway activator, that can cross the blood-brain barrier. Silybin B inhibits Aβ fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimer's disease and Cisplatin chemotherapy-related neurotoxicity .

HY-W014589S

2,4-Di-tert-butylphenol-d19

2,4-Di-tert-butylphenol-d₁₉ (2,4-DTBP-d₁₉) is the deuterium labeled 2,4-Di-tert-butylphenol (HY-W014589). 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances .

HY-W749327

2,4-Di-tert-butylphenol-d21

2,4-Di-tert-butylphenol-d₂1 (2,4-DTBP-d₂1) is the deuterium labeled 2,4-Di-tert-butylphenol (HY-W014589). 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances .

Cat. No.	Product Name		Classification

HY-B1066

Butylhydroxyanisole 5 Publications Verification Butylated hydroxyanisole; E320		Antioxidants
Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a ferroptosis inducer .

HY-132610A

Givosiran sodium 1 Publications Verification ALN-AS1 sodium		siRNAs siRNA drugs
Givosiran sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran sodium can be used for the research of acute intermittent porphyria .

HY-132610

Givosiran 1 Publications Verification ALN-AS1		siRNAs siRNA drugs
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. Givosiran can be used for the research of acute intermittent porphyria .

HY-125854

Phosphatidylcholines, egg		Phospholipids
Phosphatidylcholines, egg are a type of phosphatidylcholine that can be isolated and extracted from eggs, primarily present in egg yolks. As a major phospholipid component of cell membranes, Phosphatidylcholines, egg play a key role in providing nutrition and protection to the body. Phosphatidylcholines, egg can inhibit oxidative stress and neurotoxicity, exerting neuroprotective effects. Additionally, Phosphatidylcholines, egg can suppress the lymphatic absorption of cholesterol in the intestine and are also used in research on intestinal lipid absorption .

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