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Results for "

catalytic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (2) Aminoacyl-tRNA Synthetase (1) Amyloid-β (2) Antibiotic (2) Apoptosis (18) Aurora Kinase (2) Autophagy (3) Bacterial (6) Bcr-Abl (1) Beta-secretase (1) Biochemical Assay Reagents (27) Bradykinin Receptor (1) Btk (1) c-Met/HGFR (1) CaMK (3) Casein Kinase (1) CDK (1) Cholinesterase (ChE) (5) CMV (2) COX (2) Cytochrome P450 (1) Deubiquitinase (5) DGK (2) DNA-PK (3) DNA/RNA Synthesis (9) DOCK (1) Endogenous Metabolite (11) Epigenetic Reader Domain (14) ERK (3) FAAH (1) Factor Xa (1) FAK (1) Fatty Acid Synthase (FASN) (1) FBPase (1) Fluorescent Dye (5) Fungal (4) Glucosidase (2) Glutathione S-transferase (1) GSK-3 (1) HCV (2) HDAC (4) Hedgehog (2) HIF/HIF Prolyl-Hydroxylase (1) Histone Acetyltransferase (3) Histone Methyltransferase (5) HIV (2) HIV Integrase (2) HSV (1) IKK (2) Influenza Virus (4) Interleukin Related (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (1) LRRK2 (1) MAP3K (1) MDM-2/p53 (2) MEK (2) Methionine Adenosyltransferase (MAT) (1) Mitochondrial Metabolism (3) Mitophagy (1) Monoamine Oxidase (1) Mps1 (2) NO Synthase (1) Orthopoxvirus (1) p38 MAPK (1) Parasite (4) PARP (2) PDK-1 (1) Phosphatase (7) Phosphodiesterase (PDE) (2) PI3K (2) PIN1 (2) PINK1/Parkin (2) PKA (4) PKC (2) Polo-like Kinase (PLK) (1) Poly(ADP-ribose) Glycohydrolase (PARG) (1) PROTACs (17) Proteasome (5) Ras (1) Reactive Oxygen Species (7) Reverse Transcriptase (1) SARS-CoV (3) Ser/Thr Protease (1) STAT (2) Thrombin (1) Tie (1) Topoisomerase (7) Tyrosinase (5) Virus Protease (2)
By Research Areas:	Cancer (103) Cardiovascular Disease (8) Endocrinology (3) Infection (28) Inflammation/Immunology (25) Metabolic Disease (21) Neurological Disease (22)
Click Chemistry:	Azide (5) Alkynes (2)

253

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8245

2',3'-cGMP sodium Guanosine 2',3'-cyclic monophosphate sodium salt	Others	Others
2',3'-cGMP sodium, a cGMP analogue, is an intermediate of RNA catalytic cleavage by binase .

HY-E70017

Peptidase, microorganism Erepsin; Peptidase (IMPa)	Others	Others
Peptidase (IMPa) (Erepsin) is catalytically active enzyme that cleaves peptide bonds in proteins and peptides by hydrolysis .

HY-P2208

Z-IETD-AFC	Fluorescent Dye	Cancer
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-134398A

Kinetin triphosphate tetrasodium 6-Fu-ATP tetrasodium; KTP tetrasodium	PINK1/Parkin	Neurological Disease
Kinetin triphosphate(6-Fu-ATP) tetrasodium is an ATP analogue that regulates or enhances kinase function with higher catalytic efficiency than its endogenous substrate, ATP. Kinetin triphosphate tetrasodium can be used in Parkinson's disease research .

HY-115383

Roflupram 1 Publications Verification	Phosphodiesterase (PDE)	Neurological Disease Inflammation/Immunology
Roflupram is a selective, orally active and brain-penetrant PDE4 inhibitor, with an IC₅₀ of 26.2 nM for core catalytic domains of human PDE4. Roflupram can reverse cognitive deficits and reduce the production of pro-inflammatory factors .

HY-D1493

FIM-1	PKC	Others
FIM-1 is a fluorescent PKC (protein kinase C) probe that can be used for mitochondrial staining. FIM-1 inhibits PKC and acts as ATP-competitive catalytic site inhibitor .

HY-E70021

UDP-Glc 4-epimerase (GalE)	Others	Others
UDP-Glc 4-epimerase (GalE) is catalytically active enzyme. UDP-Glc 4-epimerase (GalE) catalyzes the reversible conversion of abundantly available UDP-glucose to UDP-galactose .

HY-134398

Kinetin triphosphate 6-Fu-ATP; KTP	PINK1/Parkin	Neurological Disease
Kinetin triphosphate(6-Fu-ATP; KTP) is an ATP analogue that regulates or enhances kinase function with higher catalytic efficiency than its endogenous substrate, ATP. Kinetin triphosphate can be used in Parkinson's disease research .

HY-118379

NU/ICRF 500	Topoisomerase	Inflammation/Immunology
NU/ICRF 500 is a topo II catalytic inhibitor which increases CREST negative micronuclei in human lymphocytes .

HY-P10463

ssK36	Histone Methyltransferase	Cancer
ssK36 is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2), and ssK36 is designed for the SETD2 protein, a specific PKMT. It is responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. ssK36 can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36. ssK36 can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency .

HY-108553

Dihydroeponemycin	Proteasome Apoptosis	Cancer
Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis .

HY-122886

XL 188	Deubiquitinase	Cancer
XL 188 is a potent and selective USP7 inhibitor with IC₅₀ values of 90 nM and 193 nM for USP7 full-length and catalytic domain enzyme, respectively. XL 188 can be used in research of cancer .

HY-161762

RA-0002034	Virus Protease	Infection
RA-0002034 is a Chikungunya virus (CHIKV) nsP2 protease inhibitor with an IC₅₀ of 58 nM. RA-0002034 covalently modifies the catalytic cysteine in a site-specific manner .

HY-P10608

KK4A peptide	HCV	Infection
KK4A peptide is a small peptide derived from nonstructural protein 4A (NS4A) of hepatitis C virus (HCV) that significantly increases the catalytic efficiency of NS3 protease. The KK4A peptide may be used to gain insights into the function and mechanism of the HCV NS3 protease, thereby advancing research into HCV infection .

HY-132233

DDO-2093	Histone Methyltransferase	Cancer
DDO-2093 is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC₅₀=8.6 nM; K_d=11.6 nM) with antitumor activity. DDO-2093 selectively inhibits the catalytic activity of MLL complex .

HY-132233A

DDO-2093 dihydrochloride	Histone Methyltransferase	Cancer
DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC₅₀=8.6 nM; K_d=11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex .

HY-149484

AChE/BChE-IN-15	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-15 (Compound 6d) is an AChE/BChE inhibitor, with IC₅₀s of 20 nM and 220 nM respectively. AChE/BChE-IN-15 binds to both catalytic anionic site (CAS) and peripheral anionic site (PAS) in the active sites of AChE and BChE. AChE/BChE-IN-15 can be used for research of Alzheimer’s disease .

HY-104001

BAY-524	Others	Cancer
BAY-524 is a potent Bub1 kinase inhibitor. BAY-524 inhibits the recombinant catalytic domain of human Bub1 with an IC₅₀ of 450 nM. BAY-524 can be used for the research of anti-cancer in combination with other agents .

HY-136276

DMNB-caged-Serine	Others	Others
DMNB-caged-Serine is a photocaged amino acid. DMNB-caged-Serine can be used as a catalytic residue, hydrogen bonding partner or site of post-translational modification. DMNB-caged-Serine can be used for the control of protein phosphorylation .

HY-148161

L82-G17	DNA/RNA Synthesis	Cancer
L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity .

HY-W001187

Tempo 3 Publications Verification	Mitochondrial Metabolism DNA/RNA Synthesis Reactive Oxygen Species	Cancer
Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells .

HY-122594

BNS-22	Topoisomerase	Cancer
BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC₅₀ values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity .

HY-124308

PS315	PKC	Cancer
PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKC_ζ (IC₅₀=10 μM) and PKC_η (IC₅₀=30 μM). PS315 has anti-cancer activity .

HY-W001187R

Tempo (Standard)	Mitochondrial Metabolism DNA/RNA Synthesis Reactive Oxygen Species	Cancer
Tempo (Standard) is the analytical standard of Tempo. This product is intended for research and analytical applications. Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells [4].

HY-135318

NBDHEX 1 Publications Verification	Apoptosis Autophagy Glutathione S-transferase	Cancer
NBDHEX is a potent glutathione S-transferase P1-1 (GSTP1-1) inhibitor. NBDHEX induces apoptosis of tumor cells. NBDHEX acts as an anticancer agent by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. NBDHEX can also act as late-phase autophagy inhibitor .

HY-P3414A

Proteasome-activating peptide 1 TFA 1 Publications Verification	Proteasome	Neurological Disease
Proteasome-activating peptide 1 TFA is a peptide and a potent proteasome activator. Proteasome-activating peptide 1 TFA increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 TFA prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis .

HY-157527

hAChE-IN-7	Cholinesterase (ChE) Beta-secretase	Neurological Disease
hAChE-IN-7 (compound 5s) is a mixed inhibitor affecting both the catalytic active site (CAS) and peripheral anionic site (PAS) of hAChE. hAChE-IN-7 displays the balanced inhibitory effect on hAChE (IC₅₀=69.8 nM) and hBuChE (IC₅₀=68.0 nM), and exhibits inhibitory activity against β-secretase-1 (BACE-1) (IC₅₀=3.6 μM). hAChE-IN-7 has the potential for Alzheimer's disease (AD) research .

HY-158038

AurkA allosteric-IN-1	Aurora Kinase	Cancer
AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC₅₀: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA .

HY-W339645

Naproxen ethyl ester (S)-Naproxen ethyl ester	Others	Inflammation/Immunology
Naproxen ethyl ester ((S)-Naproxen ethyl ester) is a nonsteroidal anti-inflammatory drug with activity in relieving pain, fever, swelling and stiffness. Naproxen ethyl ester exerts its effects by inhibiting non-selective cyclooxygenase (COX). The R-(-)-isomer of Naproxen ethyl ester shows stronger immunogenicity, and the Michaelis-Menten parameter of its catalytic reaction is K(M)=6.67 mM, and the catalytic efficiency is 5.8 x 10^4 times higher than that of the non-catalytic reaction .

HY-E70039

alpha-2-3,6,8-Sialidosidase (SpNanA)	Others	Others
alpha-2-3,6,8-Sialidosidase (SpNanA) catalyses hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates .

HY-ER019

Benzyltributylammonium chloride N-Benzyl-N,N-dibutylbutan-1-aminium chloride	Biochemical Assay Reagents	Others
Benzyltributylammonium chloride is an organic salt compound, usually used in catalytic reactions and surfactants. It can play a catalytic role in some organic synthesis reactions, and can be used as a cleaning agent, lubricant and emulsifier. In addition, the compound is widely used in certain industrial fields, such as in the plastic, rubber and textile manufacturing processes.

HY-125954B

UDP-galacturonic acid trisodium	Biochemical Assay Reagents	Metabolic Disease
UDP-galacturonic acid trisodium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase .

HY-Y1422J

Lipase PS-SD	Others	Others
Lipase PS-SD comes from Burkholderiacepacia and can be used for catalytic reaction .

HY-W054146

RAMB4 1 Publications Verification	Proteasome	Cancer
RAMB4 is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity .

HY-10461

PF-573228 15+ Cited Publications	FAK Apoptosis	Cancer
PF-573228 is a potent and selective FAK inhibitor with IC₅₀ of 4 nM for purified recombinant catalytic fragment of FAK.

HY-13565

Becatecarin NSC 655649; BMS 181176; BMY 27557	Topoisomerase	Cancer
Becatecarin is a rebeccamycin analog with antitumor effects. Becatecarin intercalates into DNA and inhibites the catalytic activity of topoisomerases I/II.

HY-N2912

Axillaridine A	Cholinesterase (ChE)	Neurological Disease
Axillaridine A can be isolated from Sarcococca hookeriana var. digyna. Axillaridine A inhibits the catalytic activity of AChE .

HY-W753281

Dexamethasone metasulfobenzoate sodium	SARS-CoV	Infection
Dexamethasone metasulfobenzoate sodium is a SARS-CoV-2 exonuclease (ExoN) inhibitor that binds to the catalytic site of ExoN .

HY-117798

LY 806303	Thrombin	Cardiovascular Disease
LY 806303 is a potent and selective inhibitor of human α-thrombin. LY 806303 specifically acylates Ser-205 within the catalytic triad of α-thrombin on the heavy chain and a key site involved in the enzymatic activity of thrombin. The mechanism of action of LY 806303 as an enzyme inhibitor is through the specific acylation of this catalytic serine residue .

HY-D0172

Tetrabutylammonium bromide AP 6G; Actiron 43-65; Aliquat 100	Biochemical Assay Reagents	Others
Tetrabutylammonium bromide is an organic ammonium compound, which is often used in catalytic reactions and separation and purification processes. It has a significant catalytic effect in some organic synthesis reactions, and can be used as a surfactant, stabilizer and antibacterial agent, etc. In addition, in some laboratory studies, this compound has also been used as an ion exchanger, solvent extractant, etc.

HY-W031536

2-Imidazolidone, 96% 2-Oxoimidazolidine, 96%	Biochemical Assay Reagents	Others
2-Imidazolidone, 96% is a chelating agent that forms complexes with metal ions, enabling its use in catalytic processes.

HY-16138

Ivaltinostat CG-200745	HDAC MDM-2/p53 Apoptosis	Cancer
Ivaltinostat (CG-200745) is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat inhibits deacetylation of histone H3 and tubulin. Ivaltinostat induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat induces apoptosis and has anti-tumour effects .

HY-132941

CFT-2718	PROTACs	Cancer
CFT-2718 is a new BRD4-targeting degrader (PROTAC) with enhanced catalytic activity and in vivo properties.

HY-P3918

EGF-R (661-681) T669 Peptide	p38 MAPK	Others
EGF-R (661-681) T669 Peptide is a MAPK substrate that can used to measure MAPK catalytic activity .

HY-W033823

Rhodium(III) oxide	Others
Rhodium(III) oxide is an inorganic compound with catalytic activity. Rhodium(III) oxide can be used as an efficient catalyst in catalytic reactions and is often used to promote chemical reactions. Rhodium(III) oxide is also widely used in energy materials, especially in fuel cells and other renewable energy technologies. Rhodium(III) oxide is studied in the field of materials science for the development of new functional materials.

HY-19416

AEOL-10150 pentachloride 1 Publications Verification	Reactive Oxygen Species	Cancer
AEOL-10150 pentachloride is a metalloporphyrin catalytic antioxidant and is a superoxide dismutase mimetic, and protects lungs from radiation-induced injury .

HY-16138A

Ivaltinostat formic CG-200745 formic	HDAC MDM-2/p53 Apoptosis	Inflammation/Immunology Endocrinology
Ivaltinostat (CG-200745) formic is an orally active, potent pan-HDAC inhibitor which has the hydroxamic acid moiety to bind zinc at the bottom of catalytic pocket. Ivaltinostat formic inhibits deacetylation of histone H3 and tubulin. Ivaltinostat formic induces the accumulation of p53, promotes p53-dependent transactivation, and enhances the expression of MDM2 and p21 (Waf1/Cip1) proteins. Ivaltinostat formic enhances the sensitivity of Gemcitabine-resistant cells to Gemcitabine (HY-16138) and 5-Fluorouracil (5-FU; HY-90006). Ivaltinostat formic induces apoptosis and has anti-tumour effects .

HY-147729

UIAA-II-232	DNA/RNA Synthesis	Infection
UIAA-II-232 (compound 19b) is a potent DNA gyrase catalytic inhibitor with an IC₅₀ value of 3.5 µM .

HY-W010179

2-Methoxynaphthalene	Biochemical Assay Reagents	Others
2-Methoxynaphthalene can be used to investigate the catalytic benefits of delamination, as well as to study alkali metal-mediated manganization (AMMMn) reactions .

HY-B2188

S-Methyl-L-cysteine L-S-Methylcysteine	Reactive Oxygen Species	Neurological Disease Metabolic Disease
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2188

S-Methyl-L-cysteine L-S-Methylcysteine	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	Reactive Oxygen Species
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

HY-N6800A

Netropsin dihydrochloride	Classification of Application Fields Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis Bacterial Influenza Virus Antibiotic Orthopoxvirus
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei . Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus .

HY-N2929

β-Hydroxypropiovanillone	Cardiovascular Disease Structural Classification Senna septemtrionalis (Viviani) H. S. Irwin & Barneby Monophenols Classification of Application Fields Leguminosae Source classification Phenols Plants Disease Research Fields	Glucosidase
β-Hydroxypropiovanillone, a natural compound, shows significant concentration-dependent inhibitory effects on α-glucosidase with an IC₅₀ of 257.8 μg/mL .

HY-A0210

Cerulenin 5 Publications Verification	Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Metabolic Disease Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics	Fatty Acid Synthase (FASN) Fungal Apoptosis Antibiotic
Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies .

HY-N2912

Axillaridine A	Structural Classification Buxaceae Terpenoids Source classification Diterpenoids Sarcococca hookeriana Baill. Sarcococca hookeriana var. digyna Franch. Plants	Cholinesterase (ChE)
Axillaridine A can be isolated from Sarcococca hookeriana var. digyna. Axillaridine A inhibits the catalytic activity of AChE .

HY-P2931

Triosephosphate isomerase TPI	Classification of Application Fields Disease Research Fields Cancer	Endogenous Metabolite
Triosephosphate isomerase (TPI) is a glycolytic enzyme. Triosephosphate isomerase fast interconverts dihydroxyacetone phosphate and D: -glyceraldehyde-3-phosphate, its catalytic site is at the dimer interface .

HY-133219

Guajadial C	Structural Classification Terpenoids Source classification Psidium guajava Linn. Myrtaceae Plants	Topoisomerase
Guajadial C is a Top1 catalytic inhibitor that delays Top1 poison-mediated DNA damage. Guajadial C shows cytotoxicity against cancer cells .

HY-N12776

Illudalic acid	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Phosphatase
Illudalic acid is a potent and selective Leukocyte antigen-related (LAR) phosphatase inhibitor with an IC₅₀ value of 1.30 µM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue .

HY-N12399

Aplithianines A	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	PKA
Aplithianines A is a potent inhibitor against J-PKA_cα with an IC₅₀ of 1 μM , and inhibits wild-type PKA with an IC₅₀ of 84 nM. Aplithianines A inhibits J-PKAcα catalytic activity by competitively binding to the ATP pocket .

HY-N10402

Norbatzelladine L	Alkaloids Microorganisms Source classification	Fungal Bacterial Parasite
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC₅₀ of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-N10401

Batzelladine D	Infection Alkaloids Structural Classification Classification of Application Fields Animals Other Alkaloids Marine natural products Sponge Disease Research Fields Cancer	Fungal Bacterial Parasite
Batzelladine D (Compound 1) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Batzelladine D inhibits Pdr5p ATPase activity with an IC₅₀ of 7.1 µM. Batzelladine D shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-113732

Kazinol F	Structural Classification Source classification Phenols Polyphenols Plants Moraceae Broussonetia papyrifera (Linnaeus) L'Heritier ex Ventenat	SARS-CoV
Kazinol F is a polyphenol from Broussonetia papyrifera. Kazinol F also is an effective Mpro inhibitor. Kazinol F has interaction with both the catalytic residues (His41 and Cys145) of Mpro and exhibits good binding affinity. Kazinol F can be used for the research of COVID-19 .

HY-N2127

Pinostrobin 1 Publications Verification	Structural Classification Monophenols Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Amyloid-β Apoptosis Ser/Thr Protease HSV Interleukin Related
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

HY-N1074

Warangalone Scandenolone	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Erythrina variegata Linn.	Parasite PKA
Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC₅₀s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibit *cyclic AMP-dependent protein kinase catalytic* subunit (cAK) with an IC₅₀** of 3.5 μM.

HY-13821

Epoxomicin Maximum Cited Publications 12 Publications Verification BU-4061T	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Inflammation/Immunology Disease Research Fields	Proteasome Apoptosis
Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity .

HY-125954A

Uridine diphosphate glucuronic acid ammonium UDP-α-D-glucuronic acid ammonium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .

HY-125954

Uridine diphosphate glucuronic acid UDP-α-D-glucuronic acid	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .

HY-E70016

Terminal deoxyribonucleotidyltransferase TdT	Classification of Application Fields Disease Research Fields Cancer	Others
Terminal deoxyribonucleotidyltransferase (TdT) catalyses the condensation of deoxyribonucleotide triphosphates onto the 3' hydroxyl ends of DNA strands and adds N-regions to gene segment junctions during V(D)J recombination. Terminal deoxyribonucleotidyltransferase is expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia/lymphoma cells .

HY-129200

Aspergillomarasmine A	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Others
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .

HY-N10159

1-Benzyl-I3C	Structural Classification Natural Products Brassica oleracea L. Source classification Plants Brassicaceae	Others
1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM, which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells, which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis, 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1 .

HY-N0086R

N6-Methyladenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Influenza Virus Endogenous Metabolite
N6-Methyladenosine (Standard) is the analytical standard of N6-Methyladenosine. This product is intended for research and analytical applications. N6-Methyladenosine is the most prevalent internal (non-cap) modification present in the messenger RNA (mRNA) of all higher eukaryotes. N6-Methyladenosine can modifies viral RNAs and has antiviral activities. In Vitro: N6-methyladenosine (m6A) is selectively recognized by the human YTH domain family 2 (YTHDF2) protein to regulate mRNA degradation. N6-methyladenosine (m6A), a prevalent internal modification in the messenger RNA of all eukaryotes, is post-transcriptionally installed by m6A methyltransferase (e.g., MT-A70) within the consensus sequence of G(m6A)C (70%) or A(m6A)C (30%). N6-methyladenosine (m6A)-containing RNAs are greatly enriched in the YTHDF-bound portion and diminished in the flow-through portion . N6-methyladenosine (m6A), the most abundant internal RNA modification, functions in diverse biological processes, including regulation of embryonic stem cell self-renewal and differentiation. N6-methyladenosine (m6A) is a large protein complex, consisting in part of methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14) catalytic subunits .

Cat. No.	Product Name	Chemical Structure

HY-W010179S1

2-Methoxynaphthalene-d2
2-Methoxynaphthalene-d2 is the deuterium labeled 2-Methoxynaphthalene (HY-W101130). 2-Methoxynaphthalene can be used to investigate the catalytic benefits of delamination, as well as to study alkali metal-mediated manganization (AMMMn) reactions .

HY-W001187S

Tempo-d18
Tempo-d₁₈ is the deuterium labeled Tempo[1]. Tempo is a classic nitroxide radical and is a selective scavenger of ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects[2][3][4][5].

HY-128463S

N-tert-Butyl-α-phenylnitrone-d14

N-tert-Butyl-α-phenylnitrone-d₁₄ is the deuterium labeled N-tert-Butyl-α-phenylnitrone[1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[2][3][4][5].

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