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Results for "

dopamine receptor agonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dopamine Receptor (178) Dopamine Transporter (4) 5-HT Receptor (82) Adrenergic Receptor (23) Akt (1) Arrestin (3) Autophagy (6) Drug Metabolite (6) GABA Receptor (1) Histamine Receptor (6) iGluR (1) Isotope-Labeled Compounds (15) mAChR (9) Microtubule/Tubulin (1) nAChR (7) Opioid Receptor (3) Potassium Channel (2) Reactive Oxygen Species (2) Serotonin Transporter (4) Sigma Receptor (3) Sodium Channel (4) Somatostatin Receptor (1) Trk Receptor (4)
By Research Areas:	Cancer (16) Cardiovascular Disease (6) Endocrinology (16) Infection (4) Inflammation/Immunology (7) Neurological Disease (204)

By Targets:

Dopamine Receptor (178)

Dopamine Transporter (4)

5-HT Receptor (82)

Adrenergic Receptor (23)

Akt (1)

Arrestin (3)

Autophagy (6)

Drug Metabolite (6)

GABA Receptor (1)

Histamine Receptor (6)

iGluR (1)

Isotope-Labeled Compounds (15)

mAChR (9)

Microtubule/Tubulin (1)

nAChR (7)

Opioid Receptor (3)

Potassium Channel (2)

Reactive Oxygen Species (2)

Serotonin Transporter (4)

Sigma Receptor (3)

Sodium Channel (4)

Somatostatin Receptor (1)

Trk Receptor (4)

By Research Areas:

Cancer (16)

Cardiovascular Disease (6)

Endocrinology (16)

Infection (4)

Inflammation/Immunology (7)

Neurological Disease (204)

223

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Dopamine Receptor Dopamine Transporter Dopamine β-hydroxylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12723

Apomorphine 5+ Cited Publications (-)-Apomorphine	Dopamine Receptor 5-HT Receptor	Neurological Disease
Apomorphine is an orally active agonist of **Dopamine receptor**. Apomorphine can be used in study Parkinson, biphasic dyskinesias, urinary dysfunction,,dystonia, dyspnoea, anismus and belching .

HY-W014728

N-Methyldopamine hydrochloride	Dopamine Receptor	Cardiovascular Disease Neurological Disease
N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research .

HY-A0007

Rotigotine Hydrochloride 1 Publications Verification N-0923 Hydrochloride	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of **dopamine receptor*, a partial agonist* of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_i of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-151515

Dopamine D2 receptor agonist-2	Dopamine Receptor	Neurological Disease
Dopamine D2 receptor agonist-2 (compound 36) is a potent **dopamine D₂ receptor** biased agonism ligand with an K_i value of 11.2 nM. Dopamine D2 receptor agonist-2 can be used to research antipsychosis .

HY-103418

Dopamine D2 receptor agonist-3	Dopamine Receptor	Neurological Disease
Dopamine D2 receptor agonist-3 (compound 3) is a selective D2 receptor partial agonist and **Dopamine D3 receptor** antagonist (with pEC₅₀ of 8.3 and <5.5 respectively) .

HY-129507

Aplindore fumarate DAB-452 fumarate	Dopamine Receptor	Neurological Disease
Aplindore fumarate (DAB-452 fumarate) is a dopamine D2 receptor partial agonist. Aplindore fumarate could be used in studies of Parkinson's disease and schizophrenia .

HY-141495A

Razpipadon (-)-PW0464	Dopamine Receptor	Neurological Disease
Razpipadon ((-)-PW0464), an aromatic compound, is a **dopamine receptor** partial agonist. Razpipadon can be used in the study of dopamine D1 ligand-mediated related psychiatric disorders .

HY-124521

Quinelorane LY163502 free base	Dopamine Receptor	Neurological Disease
Quinelorane (LY163502 free base) is a **dopamine D2 receptor** agonist. Quinelorane promotes semen ejaculation but inhibits penile erection in rats. Quinelorane can be used in the study of sexual dysfunction .

HY-U00227

U91356	Dopamine Receptor	Neurological Disease
U91356 is a **dopamine receptor** agonist.

HY-159524

Matsupexolum Matsupexole	Dopamine Receptor	Neurological Disease
Matsupexolum (Matsupexole) is a dopamine receptor agonist .

HY-15394A

(Rac)-Rotigotine N-0437	Adrenergic Receptor 5-HT Receptor Dopamine Receptor	Neurological Disease Endocrinology
(Rac)-Rotigotine (N-0437) is a racemate of Rotigotine. Rotigotine is a full agonist of **dopamine receptor*, a partial agonist* of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_is of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-12705

Bromocriptine CB-154 free base	Dopamine Receptor	Neurological Disease
Bromocriptine is a potent **dopamine D2/D3 receptor** agonist, which binds D2 dopamine receptor with pK_i of 8.05±0.2.

HY-12705A

Bromocriptine mesylate 10+ Cited Publications CB-154	Dopamine Receptor Autophagy	Neurological Disease Cancer
Bromocriptine mesylate is a potent **dopamine D2/D3 receptor** agonist, which binds D2 dopamine receptor with pK_i of 8.05±0.2.

HY-15394

(Rac)-Rotigotine hydrochloride N-0437 hydrochloride	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease Endocrinology
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of?dopamine *receptor, a partial agonist* of the?5-HT1A receptor, and an antagonist of the?α2B-adrenergic receptor, with?K_is of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-75502

Rotigotine 1 Publications Verification N-0923; (-)-N 0437	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease Endocrinology
Rotigotine is a potent **dopamine receptor** agonist with K_i values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research .

HY-A0007R

Rotigotine Hydrochloride (Standard) N-0923 Hydrochloride (Standard)	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease
Rotigotine (Hydrochloride) (Standard) is the analytical standard of Rotigotine (Hydrochloride). This product is intended for research and analytical applications. Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of **dopamine receptor*, a partial agonist* of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with K_i of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-21098A

PD-168077 maleate 1 Publications Verification	Dopamine Receptor	Neurological Disease
PD-168077 maleate is a selective dopamine D₄ receptor agonist, with a K_i of 9 nM.

HY-12236A

SKF 81297	Dopamine Receptor	Neurological Disease
SKF 81297 is a potent and selective **dopamine D1 receptor** agonist .

HY-108237

Naxagolide (+)-PHNO; Dopazinol	Dopamine Receptor	Neurological Disease
Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine *Receptor) agonist*. Naxagolide has the potential for the research of parkinson's disease (PD) .

HY-15394S

(Rac)-Rotigotine-d7 hydrochloride N-0437-d₇ hydrochloride	Isotope-Labeled Compounds Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease Endocrinology
(Rac)-Rotigotine-d₇ (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-U00400

PF-592379	Dopamine Receptor	Neurological Disease
PF-592379 is a potent **dopamine D₃ receptor** agonist with an EC₅₀ of 21 nM.

HY-12236

SKF 81297 hydrobromide	Dopamine Receptor	Neurological Disease
SKF 81297 hydrobromide is a potent and selective **dopamine D1 receptor** agonist .

HY-21098

PD-168077	Dopamine Receptor	Neurological Disease
PD-168077 is a selective dopamine D₄ receptor agonist, with a K_i of 9 nM .

HY-167915

Fosopamine hydrochloride	Others	Neurological Disease
Fosopamine hydrochloride serves as a dopamine receptor D agonist, making it a valuable tool for research on hypertension.

HY-101384A

Ro 10-5824 dihydrochloride 1 Publications Verification	Dopamine Receptor	Others
Ro 10-5824 dihydrochloride is a selective **dopamine D4 receptor** partial agonist, with K_i of 5.2 nM.

HY-101299

(+)-Dihydrexidine hydrochloride (+)-DAR-0100 hydrochloride	Dopamine Receptor	Neurological Disease
(+)-Dihydrexidine hydrochloride ((+)-DAR-0100 hydrochloride) is a **dopamine D1 receptor** agonist with an EC₅₀ of 72± 21 nM.

HY-120687

A68930	Dopamine Receptor	Cancer
A68930, as a **dopamine D1 receptor** agonist, can be used for the research of bronchiectasis .

HY-103431

A68930 hydrochloride	Dopamine Receptor	Others
A68930 hydrochloride, as a **dopamine D1 receptor** agonist, can be used for the research of bronchiectasis .

HY-75502R

Rotigotine (Standard)	Dopamine Receptor Adrenergic Receptor 5-HT Receptor	Neurological Disease Endocrinology
Rotigotine (Standard) is the analytical standard of Rotigotine. This product is intended for research and analytical applications. Rotigotine is a potent **dopamine receptor** agonist with K_i values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research .

HY-15394S1

(Rac)-Rotigotine-d3 hydrochloride N-0437-d₃ hydrochloride	Isotope-Labeled Compounds	Endocrinology
(Rac)-Rotigotine-d₃ hydrochloride is a deuterium labeled (Rac)-Rotigotine (hydrochloride) (HY-15394). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of?dopamine *receptor, a partial agonist* of the?5-HT1A receptor, and an antagonist of the?α2B-adrenergic receptor, with?K_is of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-12714

TDHL Tergurid; Terguride; trans-Dihydrolisuride	Dopamine Receptor 5-HT Receptor	Neurological Disease
TDHL (Tergurid) is a **dopamine receptor** agonist with a K_d of 0.39 nM for D2 receptor and an orally available 5-HT-2 receptor antagonist.

HY-101102

7-Hydroxy-DPAT hydrobromide	Others	Neurological Disease
7-Hydroxy-DPAT hydrobromide is a selective D3 dopamine receptor agonist, exhibiting significant pharmacological activity in modulating locomotor behavior and dopamine metabolism within the brain.

HY-P0079

Neuromedin N 2 Publications Verification Neuromedin N (rat, mouse, porcine, canine)	Dopamine Receptor	Neurological Disease
Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

HY-12520A

SKF 38393 hydrochloride 10+ Cited Publications (±)-SKF-38393 hydrochloride; SKF-38393A	Dopamine Receptor	Neurological Disease
SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC₅₀ of 110 nM .

HY-106094

CY 208-243 2 Publications Verification	Dopamine Receptor	Neurological Disease
CY 208-243 is a selective **dopamine D1 receptor** agonist which exhibits antiparkinsonian activity .

HY-14330

ABT-724	Dopamine Receptor	Neurological Disease
ABT-724 is a potent and highly selective **dopamine D₄ receptor** agonist with an EC₅₀ of 12.4 nM for human dopamine D₄ receptor. ABT-724 is a potent partial agonist at the rat D₄ (EC₅₀ of 14.3 nM) and the ferret D₄ receptor (EC₅₀ of 23.2 nM). ABT-724 has no effect on dopamine D₁, D₂, D₃, or D₅ receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile .

HY-103409

ABT-724 trihydrochloride	Dopamine Receptor	Neurological Disease
ABT-724 trihydrochloride is a potent and highly selective **dopamine D₄ receptor** agonist with an EC₅₀ of 12.4 nM for human dopamine D₄ receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D₄ (EC₅₀ of 14.3 nM) and the ferret D₄ receptor (EC₅₀ of 23.2 nM), and has no effect on dopamine D₁, D₂, D₃, or D₅ receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile .

HY-106660

BP 897 hydrochloride	Dopamine Receptor	Neurological Disease
BP 897 hydrochloride is a potent and partial **dopamine D3 receptor** agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the **dopamine D3 receptor (K_i*=0.92 nM) and a 70 times lower affinity at the D2 receptor* (K_i=61 nM) .

HY-114085

BP 897	Dopamine Receptor	Neurological Disease
BP 897 is a potent and partial **dopamine D3 receptor** agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the **dopamine D3 receptor (K_i*=0.92 nM) and a 70 times lower affinity at the D2 receptor* (K_i=61 nM) .

HY-121650

ADTN	Others	Neurological Disease
ADTN is a dopamine receptor agonist that has the activity of promoting dopamine neurotransmission. ADTN can be used to increase the release of neurotransmitters, thereby improving dopamine-related physiological functions. ADTN's potential applications include inhibiting mental illness and improving cognitive function .

HY-B1752A

Quinpirole hydrochloride 3 Publications Verification LY 171555 hydrochloride; (-)-LY 141865 hydrochloride	Dopamine Receptor	Neurological Disease
Quinpirole hydrochloride (LY 171555 hydrochloride) is a high-affinity agonist of dopamine D2/D3 receptor.

HY-A0008

Talipexole dihydrochloride B-HT 920 dihydrochloride	Adrenergic Receptor Dopamine Receptor 5-HT Receptor	Neurological Disease Endocrinology
Talipexole dihydrochloride (B-HT 920 dihydrochloride) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.

HY-109131

Foscarbidopa ABBV-951; Carbidopa 4′-monophosphate	Dopamine Receptor	Neurological Disease
Foscarbidopa (ABBV-951; Carbidopa 4′-monophosphate) is a proagent of Carbidopa, acts as a **dopamine receptor** agonist .

HY-103410

Carmoxirole hydrochloride EMD 45609 hydrochloride	Dopamine Receptor	Cardiovascular Disease
Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective, peripherally acting **dopamine D2 receptor** agonist and exhibits antihypertensive activities in vivo .

HY-105112

Carmoxirole EMD 45609	Dopamine Receptor	Cardiovascular Disease
Carmoxirole (EMD 45609) is a selective, peripherally acting **dopamine D2 receptor** agonist and exhibits antihypertensive activities in vivo .

HY-12705S

Bromocriptine-13C,d3	Isotope-Labeled Compounds Dopamine Receptor	Neurological Disease
Bromocriptine- ¹³C,d₃ is the ¹³C- and deuterium labeled Bromocriptine. Bromocriptine is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

HY-B0031S

Quetiapine-d4 fumarate	5-HT Receptor Dopamine Receptor	Neurological Disease
Quetiapine-d₄ (fumarate) is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1].

HY-120879

PF2562	Dopamine Receptor	Neurological Disease
PF2562 (Example 6), a dopamine D1 ligand, ascts as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor with a K_i of 113 nM. PF2562 exhibits activity against human D1 cAMP with an EC₅₀ of 568 nM in HTRF assay .

HY-103416

A-77636 hydrochloride 1 Publications Verification	Dopamine Receptor	Neurological Disease
A-77636 hydrochloride is a potent, orally active, selective and long acting **dopamine D1 receptor** agonist (pK_i=7.40; K_i=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor .

HY-115192

ent-Naxagolide hydrochloride ent-MK-458 hydrochloride; ent-L-647339 hydrochloride	Dopamine Receptor	Neurological Disease
ent-Naxagolide (ent-MK-458) hydrochloride is a **dopamine D2-receptor** agonist. ent-Naxagolide hydrochloride can be used in the study of extrapyramidal diseases and Parkinson's syndrome.

Cat. No.	Product Name	Target	Research Area

HY-P0079

Neuromedin N 2 Publications Verification Neuromedin N (rat, mouse, porcine, canine)	Dopamine Receptor	Neurological Disease
Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

HY-P3294

Onzigolide BIM-23A760; TBR-760	Dopamine Receptor Somatostatin Receptor	Neurological Disease Cancer
Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors .

HY-P3958

BIM-23027	Peptides	Neurological Disease
BIM-23027 is a selective agonist of sst₂ receptor (EC₅₀=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0979

Lobeline hydrochloride α-Lobeline hydrochloride; L-Lobeline hydrochloride	Alkaloids Structural Classification Source classification Campanulaceae Pyridine Alkaloids Plants Lobelia chinensis Lour.	nAChR Dopamine Transporter
Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Alkaloids Stephania intermedia Source classification Plants Isoquinoline Alkaloids Menispermaceae	Dopamine Receptor
L-Stepholidine (Stepholidine) exhibits mixed **dopamine D1 receptor** agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction .

HY-101078A

(±)-Epibatidine dihydrochloride CMI 545 dihydrochloride	Alkaloids Structural Classification Animals Source classification Pyridine Alkaloids	Others
(±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. (±)-Epibatidine (CMI 545) dihydrochloride is an alkaloid originally characterized from frog skin. (±)-Epibatidine (CMI 545) dihydrochloride have little or no activity at a variety of other central receptors, including opioid receptors, muscarinic receptors, adrenergic receptors, dopamine receptors, serotonin receptors, and gamma-aminobutyric acid receptors .

HY-135525

Agroclavine	Infection Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids Cancer	Dopamine Receptor Adrenergic Receptor
Agroclavine is a natural, clavine type of ergot alkaloid. Agroclavine is a D1 **dopamine receptor and α1-adrenoceptor** agonist. Agroclavine also has anticancer and antimicrobial activities .

HY-B1423

Lobeline α-Lobeline; L-Lobeline	Structural Classification Alkaloids Other Alkaloids Source classification Campanulaceae Plants Lobelia chinensis Lour.	nAChR Dopamine Transporter
Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation .

HY-128420

Lobeline sulfate α-Lobeline sulfate; L-Lobeline sulfate	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Endogenous metabolite	nAChR Dopamine Transporter
Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation .

HY-B0979R

Lobeline hydrochloride (Standard)	Alkaloids Structural Classification Source classification Campanulaceae Pyridine Alkaloids Plants Lobelia chinensis Lour.	nAChR Dopamine Transporter
Lobeline (hydrochloride) (Standard) is the analytical standard of Lobeline (hydrochloride). This product is intended for research and analytical applications. Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

Cat. No.	Product Name	Chemical Structure

HY-B0031S1

Quetiapine-d4 hemifumarate
Quetiapine-d₄ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1].

HY-15394S

(Rac)-Rotigotine-d7 hydrochloride

(Rac)-Rotigotine-d₇ (hydrochloride) is deuterium labeled (Rac)-Rotigotine (hydrochloride). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Kis of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-15394S1

(Rac)-Rotigotine-d3 hydrochloride

(Rac)-Rotigotine-d₃ hydrochloride is a deuterium labeled (Rac)-Rotigotine (hydrochloride) (HY-15394). (Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of?dopamine receptor, a partial agonist of the?5-HT1A receptor, and an antagonist of the?α2B-adrenergic receptor, with?K_is of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.

HY-12705S

Bromocriptine-13C,d3
Bromocriptine- ¹³C,d₃ is the ¹³C- and deuterium labeled Bromocriptine. Bromocriptine is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.

HY-B0031S

Quetiapine-d4 fumarate
Quetiapine-d₄ (fumarate) is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects[1].

HY-A0007S

Rotigotine-d7 hydrochloride
Rotigotine-d₇ (hydrochloride) is the deuterium labeled Rotigotine(N-0923), which is a dopamine D2 and D3 receptor agonist.

HY-G0014S

Quetiapine Sulfoxide-d8
Quetiapine Sulfoxide-d₈ is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic[1]. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist[1][2].

HY-13720S

Pergolide-d7 hydrochloride
Pergolide-d₇ hydrochloride is deuterated labeled Pergolide (HY-13720). Pergolide (LY127809 (free base)) is an ergot-derived orally active **dopamine receptor** agonist. Pergolide can be used for Parkinson disease research .

HY-13720AS

Pergolide-d7 mesylate
Pergolide-d₇ (mesylate) is the deuterium labeled Pergolide mesylate. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].

HY-15296S1

Cabergoline-d6
Cabergoline-d₆ is deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).

HY-15296S

Cabergoline-d5
Cabergoline-d₅ is the deuterium labeled Cabergoline. Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively)[1][2].

HY-15780S

Brexpiprazole-d8
Brexpiprazole-d₈ is a deuterium labeled Brexpiprazole (OPC-34712). Brexpiprazole, an atypical antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine receptor (Ki=0.12 nM and 0.3 nM, respectively). Brexpiprazole is also a 5-HT2A receptor antagonist (Ki=0.47 nM)[1][2].

HY-17355S

Pramipexole-d7 dihydrochloride

Pramipexole-d₇ (dihydrochloride) is the deuterium labeled Pramipexole dihydrochloride. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

HY-17355S1

Pramipexole-d5 dihydrochloride

Pramipexole-d₅ (dihydrochloride) is deuterium labeled Pramipexole (dihydrochloride). Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

HY-A0095S1

Flibanserin-d4-1

Flibanserin-d₄-1 is deuterium labeled Flibanserin. Flibanserin (BIMT-17) is a full agonist of the serotonin 5-HT1A receptor (Ki=1 nM) and an antagonist of 5-HT2A (49 nM). Flibanserin binds to dopamine D4 receptors (4-24 nM), and has negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin is efficacious in treating hypoactive sexual desire disorder (HSDD)[1][2].

HY-B0410S1

Pramipexole-d5
Pramipexole-d₅ is the deuterium labeled Pramipexole[1]. Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[2][3][4].

HY-B0032AS

Lurasidone-d8
Lurasidone-d₈ is deuterium labeled Lurasidone. Lurasidone (SM-13496) is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (SM-13496) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.

HY-17355S2

Pramipexole-d7-1 dihydrochloride

Pramipexole-d₇-1 (dihydrochloride) is the deuterium labeled Pramipexole dihydrochloride[1]. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[2][3][4].

HY-B0031S2

Quetiapine-d8 fumarate

Quetiapine-d₈ (fumarate) is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1][2].

HY-B0527AS

Amitriptyline-d6 hydrochloride

Amitriptyline-d₆ (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity[1][2][3].

HY-B0031S3

Quetiapine-d8 hemifumarate

Quetiapine-d₈ (hemifumarate) is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

HY-B0031S4

Quetiapine hemifumarate-d8

Quetiapine (hemifumarate)-d₈ is the deuterium labeled Quetiapine hemifumarate[1]. Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[2].

HY-B0031S5

Quetiapine-d4-1 fumarate

Quetiapine-d₄-1 fumarate is deuterated labeled Quetiapine (hemifumarate) (HY-B0031). Quetiapine hemifumarate is a 5-HT receptors agonist with a pEC₅₀ of 4.77 for human 5-HT1A receptor. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC₅₀ of 6.33 for human D2 receptor. Quetiapine hemifumarate has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pK_is of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects .

HY-133152S

Brexpiprazole S-oxide-d8

Brexpiprazole S-oxide-d₈ is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM[1][2][3].

HY-15780S1

Brexpiprazole-d8-1

Brexpiprazole-d₈-1 is the deuterium labeled Brexpiprazole[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[2][3].

HY-B1658BS

Frovatriptan-d3 succinate

Frovatriptan-d₃ (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].

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