Topoisomerase

Topoisomerase Isoform Specific Products:

Topoisomerase Related Products (562)
Antibodies (4)
Topoisomerase Isoform Comparison

By Effects:	Controls (3) Inhibitors (537) Agonists (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-122481

Thaspine acetate	Inhibitor
Thaspine acetate, an alkaloid, is a topoisomerase I and II inhibitor. Thaspine acetate induces cancer cell apoptosis. Thaspine acetate induces Bak and Bax activation, mitochondrial cytochrome c release and mitochondrial membrane permeabilization. Thaspine acetate can be isoalted from the cortex of the South American tree Croton lechleri.

HY-400316

Exatecan intermediate 8	Inhibitor
Exatecan intermediate 8 is an intermediate for the synthesis of Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM).

HY-46081

Exatecan Intermediate 3	Inhibitor
Exatecan Intermediate 3 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 3 can be used to synthesize Antibody-Drug Conjugates (ADCs).

HY-161813

Antibacterial agent 229	Inhibitor
Antibacterial agent 229 (compound 8a) is a potent antibacterial agent. Antibacterial agent 229 shows antibacterial and antifungal abilities. Antibacterial agent 229 disrupts the integrity of the bacterial membrane, intercalates into DNA. Antibacterial agent 229 inhibits topoisomerase IV with an IC₅₀ value of 10.88 µM.

HY-117657

(-)-BO 2367	Inhibitor
(-)-BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-)-BO 2367 shows IC₅₀ values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-)-BO 2367 is a potent antitumor agent.

HY-16562R

Irinotecan (Standard)	Inhibitor
Irinotecan (Standard) is the analytical standard of Irinotecan. This product is intended for research and analytical applications. Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.

HY-W178011

Topoisomerase IIα-IN-9	Inhibitor
Topoisomerase IIα-IN-9 (NSC85582) is a bisphenol compound that has a moderate inhibitory effect on DNA topoisomerase Topoisomerase II (IC₅₀: 571 μM). Topoisomerase IIα-IN-9 also exhibits a certain cell growth inhibitory effect, with IC₅₀s of 117 μM and 218 μM for K562 and CHO, respectively.

HY-B0879AR

Suramin (sodium salt) (Standard)	Inhibitor
Suramin (sodium salt) (Standard) is the analytical standard of Suramin (sodium salt). This product is intended for research and analytical applications. Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC₅₀=297 nM), SirT2 (IC₅₀=1.15 μM), and SirT5 (IC₅₀=22 μM). Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC₅₀=5 μM). Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor. Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent.

HY-13704R

SN-38 (Standard)	Inhibitor
SN-38 (Standard) is the analytical standard of SN-38. This product is intended for research and analytical applications. SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254).

HY-13551R

Amsacrine (Standard)	Inhibitor
Amsacrine (Standard) is the analytical standard of Amsacrine. This product is intended for research and analytical applications. Amsacrine (m-AMSA; acridinyl anisidide) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.

HY-13565

Becatecarin	Inhibitor
Becatecarin is a rebeccamycin analog with antitumor effects. Becatecarin intercalates into DNA and inhibites the catalytic activity of topoisomerases I/II.

HY-134290A

8-Chloro-ATP tetrasodium	Inhibitor
8-Chloro-ATP tetrasodium, an ATP (HY-B2176) analog, is a topoisomerase II (Topo II) inhibitor. 8-Chloro-ATP tetrasodium inhibits DNA synthesis and induces DNA double-stranded breaks (DSBs). 8-Chloro-ATP tetrasodium inhibits Topo II-catalyzed ATP hydrolysis.

HY-161937

Antibacterial agent 236	Inhibitor
Antibacterial agent 236 (Compound 4l) is an orally active inhibitor for DNA gyrase and topoisomerase IV (IC₅₀ is 3.2 and 300 nM in Staphylococcus aureus), and exhibits board-spectrum antibacterial activity. Antibacterial agent 236 exhibits good pharmacokinetic properties in mice.

HY-13629R

Etoposide (Standard)	Inhibitor
Etoposide (Standard) is the analytical standard of Etoposide. This product is intended for research and analytical applications. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.

HY-13768AR

Topotecan (hydrochloride) (Standard)	Inhibitor
Topotecan (hydrochloride) (Standard) is the analytical standard of Topotecan (hydrochloride). This product is intended for research and analytical applications. Topotecan Hydrochloride (SKF 104864A Hydrochloride) is a Topoisomerase I inhibitor with potent antineoplastic activities.

HY-W010800R

Cholesteryl hemisuccinate (Standard)	Inhibitor

HY-13629S

Etoposide-d₃	Inhibitor
Etoposide-d3 (VP-16-d3) is the deuterium labeled Etoposide (HY-13629). Etoposide (VP-16) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.

HY-13761R

Teniposide (Standard)	Inhibitor
Teniposide (Standard) is the analytical standard of Teniposide. This product is intended for research and analytical applications. Teniposide is a podophyllotoxin derivative, acts as a topoisomerase II inhibitor, and used as a chemotherapeutic agent.

HY-116231

(S)-Gyramide A	Inhibitor
(S)-Gyramide A is a weak inhibitor of cell proliferation that can target DNA gyrase.

HY-17460

Garenoxacin	Inhibitor
Garenoxacin (BMS284756) is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms.

Doxorubicin hydrochloride		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM	99.90%
Etoposide			Topoisomerase II	99.94%
Dxd		Topoisomerase I, IC₅₀: 0.31 μM		99.30%
SN-38		Topoisomerase I		99.89%
Camptothecin		Topoisomerase I, IC₅₀: 679 nM		99.86%
Irinotecan		Topoisomerase I		99.97%
Topotecan hydrochloride		Topoisomerase I		99.89%
Daunorubicin hydrochloride			Topoisomerase II	99.67%
Mitoxantrone			Topoisomerase II	99.58%
Epirubicin hydrochloride	Topoisomerase			99.16%
Irinotecan hydrochloride		Topoisomerase I		99.89%
Datopotamab deruxtecan		Topoisomerase I		99.54%
Levofloxacin	TOPO IV			99.92%
Idarubicin hydrochloride			Topoisomerase II	99.94%
Betulinic acid		Topoisomerase I, IC₅₀: 5 μM		98.43%
Mitoxantrone dihydrochloride			Topoisomerase II	99.55%
Dxd-d₅		Topoisomerase I, IC₅₀: 0.31 μM		98.84%
β-Lapachone		Topoisomerase I		99.99%
Teniposide			Topoisomerase II	99.00%
Pirarubicin			Topoisomerase II	99.61%
Irinotecan hydrochloride trihydrate		Topoisomerase I		99.89%
Belotecan hydrochloride		Top1		99.88%
PNU-159682		Topoisomerase I		98.25%
Etoposide phosphate			Topoisomerase II
Aldoxorubicin			Topoisomerase II
Aclacinomycin A		Topoisomerase I	Topoisomerase II	99.30%
Aurintricarboxylic acid			Topoisomerase II
Banoxantrone dihydrochloride			Topoisomerase II	99.46%
Nalidixic acid	Topoisomerase			99.97%
Proscillaridin A		Topoisomerase I, IC₅₀: 30 nM	Topoisomerase II, IC₅₀: 100 nM	99.74%
Levofloxacin hydrate	TOPO IV			99.93%
Pirarubicin Hydrochloride			Topoisomerase II	98.56%
Pixantrone			Topoisomerase II	98.75%
(S)-10-Hydroxycamptothecin		Topoisomerase I		99.38%
Ellipticine			Topoisomerase II	99.56%
Bisantrene			Topoisomerase II	98.08%
Amsacrine			Topoisomerase II	99.95%
Gatifloxacin			Topoisomerase II, IC₅₀: 36.7 μM	99.69%
MC-GGFG-AM-(10Me-11F-Camptothecin)		Topoisomerase I		98.06%
PluriSIn #2			topoisomerase II alpha	≥98.0%
Ellipticine hydrochloride			Topoisomerase II	99.34%
Hycanthone		Topoisomerase I	Topoisomerase II	99.97%
Amonafide			Topoisomerase II	99.92%
Voreloxin Hydrochloride			Topoisomerase II	99.58%
Coralyne chloride		Topoisomerase I		98.30%
MC-DOXHZN hydrochloride			Topoisomerase II	98.04%
Amsacrine hydrochloride			Topoisomerase II	99.98%
TAS-103 dihydrochloride		Topoisomerase I	Topoisomerase II	98.87%
Amrubicin			Topoisomerase II	≥98.0%
Genz-644282		Topoisomerase I		99.53%
Chloroquinoxaline sulfonamide			topoisomerase II alpha topoisomerase II beta	99.06%
9-Aminocamptothecin		Topoisomerase I		98.89%
Indotecan		Topoisomerase I		≥98.0%
(±)-10-Hydroxycamptothecin		Topoisomerase I		99.57%
Nalidixic acid sodium salt	Topoisomerase			99.83%
Intoplicine		Topoisomerase I	Topoisomerase II	98.36%
Gatifloxacin hydrochloride			Topoisomerase II, : 36.7 μM	99.94%
Daun02	Topoisomerase			98.72%
Flumequine			Topoisomerase II, IC₅₀: 15 μM
Gimatecan		Topoisomerase I		99.28%
(±)-Evodiamine		Top1		99.74%
Lurtotecan		Topoisomerase I		98.01%
Isodiospyrin		Topoisomerase I		99.77%
Karenitecin		Topoisomerase I		98.02%
LMP744 hydrochloride		Top1		99.70%
Groenlandicine		Topoisomerase I		99.87%
Indimitecan		Top1		98.30%
ARN-21934			topoisomerase II alpha topoisomerase II beta	98.08%
Levofloxacin hydrochloride	TOPO IV			≥98.0%
Podocarpusflavone A		Topoisomerase I, IC₅₀: 119.425 μM		99.62%
LMP517		Topoisomerase I	Topoisomerase II	99.58%
Garenoxacin Mesylate hydrate	TOPO IV, IC₅₀: 1.5-2.5 μg/mL			99.78%
LMP744		Top1		98.85%
Aclacinomycin A hydrochloride		Topoisomerase I	Topoisomerase II
Namitecan		Topoisomerase I		99.25%
Topoisomerase I inhibitor 8		Topoisomerase I
Elomotecan hydrochloride		Topoisomerase I	Topoisomerase II
Epirubicin	Topoisomerase			98.45%
Topoisomerase II inhibitor 20 TFA			Topoisomerase II, IC₅₀: 0.98 μM
9-Hydroxyellipticine hydrochloride			Topoisomerase II	≥99.0%
SW044248		Topoisomerase I		99.60%
Topotecan		Topoisomerase I
Doxorubicin		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM
Daunorubicin			Topoisomerase II
Topoisomerase II inhibitor 20			Topoisomerase II, IC₅₀: 0.98 μM	98.44%
CH-0793076		Topoisomerase I, IC₅₀: 2.3 μM
AQ4			Topoisomerase II
BNS-22			topoisomerase II alpha, IC₅₀: 2.8 μM (in human) topoisomerase II beta, IC₅₀: 0.42 μM (in human)	99%
Seconeolitsine		Topoisomerase I, IC₅₀: 17 μM
Edotecarin		Topoisomerase I, IC₅₀: 50 nM		98.39%
CH-0793076 TFA		Topoisomerase I, IC₅₀: 2.3 μM		98.71%
Zabofloxacin		Topoisomerase I	Topoisomerase II	98.02%
Zabofloxacin hydrochloride		Topoisomerase I	Topoisomerase II	99.54%
Amrubicin hydrochloride			Topoisomerase II
Pixantrone free base			Topoisomerase II
Voreloxin			Topoisomerase II	99.26%
TAS-103		Topoisomerase I	Topoisomerase II
MC-DOXHZN			Topoisomerase II
Topotecan hydrochloride hydrate		Topoisomerase I
Etoposide phosphate disodium			Topoisomerase II
Idarubicin			Topoisomerase II
Gatifloxacin sesquihydrate			Topoisomerase II, IC₅₀: 36.7 μM
Rebeccamycin		Topoisomerase I
Mitoxantrone diacetate			Topoisomerase II
CBX-12		Topoisomerase I
Daunorubicin citrate			Topoisomerase II
Antitumor agent-63		Top1
Silatecan		Topoisomerase I
Topoisomerase II inhibitor 9			Topoisomerase II, IC₅₀: 0.97 μM
Topo I/COX-2-IN-1		Topoisomerase I, IC₅₀: 4.42 μM
Bimolane			Topoisomerase II
T-2513 hydrochloride		Topoisomerase I
TOPOI/PARP-1-IN-2		Top1, IC₅₀: 46.2 nM
Topo I/COX-2-IN-2		Topoisomerase I, IC₅₀: 0.90 μM
Topoisomerase II inhibitor 11			Topoisomerase II, IC₅₀: 2.89 μM
CS1			topoisomerase II alpha
T-2513		Topoisomerase I
Razoxane			Topoisomerase II	99.16%
Topoisomerase IIα-IN-3			topoisomerase II alpha
Heliquinomycin		Topoisomerase I	Topoisomerase II
Topoisomerase II/EGFR-IN-1			Topoisomerase II
VcMMAE-Deruxtecan		Topoisomerase I
Anticancer agent 75			Topoisomerase II
CP-67804			Topoisomerase II
DTS-108		Top1
Pixantrone hydrochloride			Topoisomerase II
Topoisomerase II inhibitor 4			Topoisomerase II
Topoisomerase IIα-IN-6			topoisomerase II alpha, IC₅₀: 0.67 μM
Topoisomerase IIα-IN-2			topoisomerase II alpha topoisomerase II beta
Topoisomerase IIα-IN-4			topoisomerase II alpha, IC₅₀: 3.8 μM topoisomerase II beta, IC₅₀: 10.1 μM
ZLHQ-5f		Top1
3-Fluoro-evodiamine glucose		Topoisomerase I	Topoisomerase II
Topo I-IN-1		Topoisomerase I
Topoisomerase I/II inhibitor 6		Topoisomerase I, IC₅₀: 4.77 μM	Topoisomerase II, IC₅₀: 15 μM
EGFR-IN-116			Topoisomerase II, IC₅₀: 19.74 μM
Top/HDAC-IN-2		Top1	Topoisomerase II
Anti-MRSA agent 7	TOPO IV, IC₅₀: 0.059 μM (E. coli ) TOPO IV, IC₅₀: 0.341 μM (S. aureus)
Topoisomerase II inhibitor 18			Topoisomerase II, IC₅₀: 7.5 μM
Topoisomerase I inhibitor 17		Top1
Elomotecan		Topoisomerase I	Topoisomerase II
Topoisomerase II inhibitor 5			Topoisomerase II
LE01		Topoisomerase I
HSP90-IN-13	Topoisomerase-2, IC₅₀: 25.85 nM
Topoisomerase I inhibitor 2		Topoisomerase I, IC₅₀: 0.58 μM
iNOS/TopoI-IN-1		Topoisomerase I, Ki: 2.72 μM
Topoisomerase II inhibitor 10			Topoisomerase II, IC₅₀: 7.45 μM
Salvicine			Topoisomerase II, IC₅₀: 3 μM
Topoisomerase IV inhibitor 1	TOPO IV, IC₅₀: 0.23 μM
Topoisomerase II inhibitor 13			Topoisomerase II	99.26%
EGFR-IN-57			topoisomerase II beta, IC₅₀: 0.13 μM
Topoisomerase IIα-IN-1			topoisomerase II alpha topoisomerase II beta
Huanglongmycin N		Topoisomerase I, EC₅₀: 14 μM
Topoisomerase IIα-IN-8			topoisomerase II alpha
Tilatamig samrotecan		Topoisomerase I
Deruxtecan-Eribulin		Topoisomerase I
CP-67015			Topoisomerase II
Tapcin		Topoisomerase I, IC₅₀: 203 nM	Topoisomerase II, IC₅₀: 71 nM
Topoisomerase I inhibitor 12		Topoisomerase I
Topoisomerase II inhibitor 17			Topoisomerase II, IC₅₀: 0.23 μM
Topoisomerase I/II inhibitor 2		Topoisomerase I	Topoisomerase II
Topo I/II-IN-2		Topoisomerase I	Topoisomerase II
Saintopin		Topoisomerase I	Topoisomerase II
Intoplicine dimesylate		Topoisomerase I	Topoisomerase II	98.28%
Topoisomerase IV inhibitor 2	TOPO IV, IC₅₀: 0.35 μM
Topoisomerase II inhibitor 7			topoisomerase II alpha, IC₅₀: 3.19 μM
Topoisomerase I/II inhibitor 7		Topoisomerase I	Topoisomerase II
Topoisomerase IIα-IN-7			topoisomerase II alpha, IC₅₀: 7.7 μM
Niranthin	Topoisomerase
Epolactaene			Topoisomerase II, IC₅₀: 10 μM
Topoisomerase I inhibitor 3		Topoisomerase I
Topoisomerase II inhibitor 19			Topoisomerase II, IC₅₀: 0.34 μM
Corydamine		Topoisomerase I	Topoisomerase II
TP0480066			Topoisomerase II
AZD5099			Topoisomerase II
Topoisomerase I inhibitor 16		Topoisomerase I
TP3011		Topoisomerase I
Topoisomerase II inhibitor 8			Topoisomerase II, IC₅₀: 0.52 μM
Topoisomerase I/II inhibitor 3		Topoisomerase I	Topoisomerase II
Gatifloxacin mesylate			Topoisomerase II, IC₅₀: 36.7 μM
Topoisomerase IIα-IN-5			topoisomerase II alpha
Bakuchicin			Topoisomerase II, IC₅₀: 404 μM
Thaspine acetate		Topoisomerase I	Topoisomerase II
Antibacterial agent 229	TOPO IV, IC₅₀: 10.88 μM
(-)-BO 2367			Topoisomerase II
8-Chloro-ATP tetrasodium			Topoisomerase II
Garenoxacin	TOPO IV, IC₅₀: 1.5-2.5 μg/mL
HU 331			Topoisomerase II
Luotonin F			Topoisomerase II
Topovale		Topoisomerase I
NK 314			topoisomerase II alpha
8-Chloro-ATP			Topoisomerase II

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Topoisomerase

Topoisomerase

Topoisomerase Isoform Specific Products:

Topoisomerase Isoform Specific Products:

Topoisomerase Related Products (562)

Antibodies (4)

Topoisomerase Isoform Comparison

Topoisomerase Related Products (562):