Search Result

Pathways Recommended:	MAPK/ERK Pathway Neuronal Signaling JAK/STAT Signaling

Results for "

MAPK signaling

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MAP4K (1) MAPKAPK2 (MK2) (3) p38 MAPK (54) Adrenergic Receptor (1) Akt (12) AMPK (4) Androgen Receptor (1) AP-1 (1) Apoptosis (33) Arginase (1) Atg8/LC3 (2) Autophagy (14) Bacterial (6) Bcl-2 Family (1) c-Myc (2) Cannabinoid Receptor (2) Casein Kinase (1) Caspase (2) CCR (1) CDK (1) Cholinesterase (ChE) (2) COX (14) Cytochrome P450 (1) Dengue virus (1) EGFR (2) Endogenous Metabolite (6) ERK (24) FAK (3) Flavivirus (1) Fungal (2) GnRH Receptor (1) GSK-3 (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) HIV (4) IKK (4) Influenza Virus (2) Interleukin Related (8) IRAK (1) JAK (6) JNK (9) Keap1-Nrf2 (3) MAP3K (1) MEK (3) mTOR (2) Necroptosis (2) NF-κB (47) NO Synthase (11) NOD-like Receptor (NLR) (3) p62 (2) PAK (1) Parasite (4) Phosphatase (2) PI3K (8) Potassium Channel (3) PROTACs (2) Protease Activated Receptor (PAR) (1) Raf (9) RANKL/RANK (1) Ras (6) Reactive Oxygen Species (8) RET (1) SHP2 (1) Src (1) STAT (7) TGF-β Receptor (1) TNF Receptor (14) Toll-like Receptor (TLR) (4) Topoisomerase (2) Trk Receptor (1) Tyrosinase (2) VEGFR (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (85) Cardiovascular Disease (12) Endocrinology (2) Infection (12) Inflammation/Immunology (77) Metabolic Disease (14) Neurological Disease (18)

By Targets:

MAP4K (1)

MAPKAPK2 (MK2) (3)

p38 MAPK (54)

Adrenergic Receptor (1)

Akt (12)

AMPK (4)

Androgen Receptor (1)

AP-1 (1)

Apoptosis (33)

Arginase (1)

Atg8/LC3 (2)

Autophagy (14)

Bacterial (6)

Bcl-2 Family (1)

c-Myc (2)

Cannabinoid Receptor (2)

Casein Kinase (1)

Caspase (2)

CCR (1)

CDK (1)

Cholinesterase (ChE) (2)

COX (14)

Cytochrome P450 (1)

Dengue virus (1)

EGFR (2)

Endogenous Metabolite (6)

ERK (24)

FAK (3)

Flavivirus (1)

Fungal (2)

GnRH Receptor (1)

GSK-3 (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Methyltransferase (1)

HIV (4)

IKK (4)

Influenza Virus (2)

Interleukin Related (8)

IRAK (1)

JAK (6)

JNK (9)

Keap1-Nrf2 (3)

MAP3K (1)

MEK (3)

mTOR (2)

Necroptosis (2)

NF-κB (47)

NO Synthase (11)

NOD-like Receptor (NLR) (3)

p62 (2)

PAK (1)

Parasite (4)

Phosphatase (2)

PI3K (8)

Potassium Channel (3)

PROTACs (2)

Protease Activated Receptor (PAR) (1)

Raf (9)

RANKL/RANK (1)

Ras (6)

Reactive Oxygen Species (8)

RET (1)

SHP2 (1)

Src (1)

STAT (7)

TGF-β Receptor (1)

TNF Receptor (14)

Toll-like Receptor (TLR) (4)

Topoisomerase (2)

Trk Receptor (1)

Tyrosinase (2)

VEGFR (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (85)

Cardiovascular Disease (12)

Endocrinology (2)

Infection (12)

Inflammation/Immunology (77)

Metabolic Disease (14)

Neurological Disease (18)

153

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

APS6-45	Ras	Cancer
APS6-45 is an orally active tumor-calibrated inhibitor (TCI). APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity .

MAPK-IN-1 1 Publications Verification	Toll-like Receptor (TLR) p38 MAPK JNK ERK Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC₅₀ of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research .

ERK1/2 inhibitor 4	ERK	Inflammation/Immunology Cancer
ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 5 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2020238776A1) .

ERK1/2 inhibitor 5	ERK	Cancer
ERK1/2 inhibitor 5 is a potent inhibitor of ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 5 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2020238776A1) .

ERK1/2 inhibitor 3	ERK	Inflammation/Immunology Cancer
ERK1/2 inhibitor 3 is a potent inhibitor of ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 3 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2021218912A1, compound 1) .

ERK1/2 inhibitor 6	ERK	Inflammation/Immunology Cancer
ERK1/2 inhibitor 6 is a potent inhibitor of ERK1/2. Mitogen-activated protein kinase (MAPK) plays an extremely important role in the signal transduction pathway, and extracellular signal regulated kinase (ERK) is a member of the MAPK family. ERK1/2 inhibitor 6 has the potential for the research or prevention of cancer, inflammation or other proliferative diseases (extracted from patent WO2021063335A1, compound 1) .

DCZ19931	ERK p38 MAPK	Cardiovascular Disease
DCZ19931 is a potent multi-targeting kinase inhibitor. DCZ19931 has anti-angiogenic effects on ocular neovascularization. DCZ19931 also inhibits ERK1/2-MAPK and p38-MAPK signaling .

Cannabisin D	p38 MAPK	Neurological Disease
Cannabisin D inhibits proliferation and migration of glioblastoma cells through MAPKs signaling .

Akt/NF-κB/MAPK-IN-1	p38 MAPK ERK JNK Interleukin Related TNF Receptor NO Synthase COX	Others
Akt/NF-κB/MAPK-IN-1 (compound 2m) is a potent and orally active inhibitor against NO (IC₅₀=7.70 μM) with no significant toxicity. Akt/NF-κB/MAPK-IN-1 shows anti-inflammatory activity by inhibiting Akt/NF-κB and MAPK signaling pathways .

Salixteroside D	p38 MAPK NF-κB	Inflammation/Immunology
Salixteroside D is a salicin derivative, that exhibits anti-inflammatory activity through inhibition of MAPK and NF-κB signaling pathways .

NF-κB/MAPK-IN-1	NF-κB p38 MAPK NO Synthase COX	Inflammation/Immunology
NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and *MAPK* pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC₅₀ of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research .

Debromohymenialdisine 10Z-Debromohymenialdisine	Raf MEK	Cancer
Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC₅₀ value of 881 nM in the initial *Raf/MEK-1/MAPK* signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation .

Tat-braftide	Raf	Cancer
Tat-braftide is a peptide inhibitor designed to block the dimerization of BRAF, thereby inhibiting its kinase activity. The destruction of BRAF dimer by Tat-braftide makes BRAF protein more susceptible to proteasome degradation, directly inhibits the activity of BRAF kinase, and reduces the activation of MAPK signaling pathway. Tat-braftide can be used for the role of RAF kinase in MAPK signaling pathway and for the study of BRAF mutant cancers .

ASK1-IN-4	MAP3K Apoptosis	Inflammation/Immunology Cancer
ASK1-IN-4 (Compound 17) is an ASK1 inhibitor (IC₅₀=0.2 μM). ASK1-IN-4 interacts with ATP-binding site of ASK1 .

Anti-inflammatory agent 7	p38 MAPK NF-κB	Inflammation/Immunology
Anti-inflammatory agent 7 inhibits proinflammatory cytokines by blocking the *NF-κB/MAPK* signaling pathway in LPS-treated RAW 264.7 cells as well as mice.

Asperuloside 2 Publications Verification	NO Synthase	Metabolic Disease Inflammation/Immunology
Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .

Tanshinol borneol ester	Akt AMPK	Cardiovascular Disease
Tanshinol borneol ester, an angiogenesis stimulator, promoted multiple key steps of angiogenesis through Akt and *MAPK* signalling pathways. Tanshinol borneol ester has anti-ischemic and anti-atherosclerosis activities .

Nimustine	Apoptosis	Cancer
Nimustine is a nitrosourea alkylating agent. Nimustine induces cell apoptosis, and activates DNA damage response and *MAPK* signaling. Nimustine shows anti-cancer effects, it can be used for the research of cancer .

Goshonoside F5	NF-κB	Inflammation/Immunology
Goshonoside F5 can be isolated from the unripe fruits of Rubus chingii. Goshonoside F5 has anti-inflammatory activity, and inhibits NF-κB and MAPK signaling pathway .

LX-3	p38 MAPK	Cancer
LX-3 is a selective activator of the p38 MAPK signaling pathway and activates EGFP reporter genes that are silenced by DNA methylation, such as TNF, EGR1, LY6K, and ISG20 .

p-Cresyl sulfate potassium 4 Publications Verification p-Tolyl sulfate potassium	Endogenous Metabolite JNK p38 MAPK	Metabolic Disease Inflammation/Immunology
p-Cresyl sulfate potassium is a uremic toxin that binds to a prototype protein. p-Cresyl sulfate potassium activates the JNK and p38 MAPK signaling pathways. p-Cresyl sulfate potassium has pro-inflammatory activity .

Anticancer agent 124	Raf	Cancer
Anticancer agent 124 is an orally active, highly selective and potent pan RAF inhibitor. Anticancer agent 124 inhibits *MAPK* signalling in BRAF V600E, NRAS and KRAS mutant tumor cells .

Chitosan oligosaccharide 4 Publications Verification COS	AMPK Endogenous Metabolite	Metabolic Disease Cancer
Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and *MAPK* pathways.

Niloticin	Akt NF-κB	Infection
Niloticin, tetracyclic triterpenoid compound, is a osteoclastogenesis inhibitor. Niloticin shows anti-viral, antioxidative, and mosquitocidal activities. Niloticin inhibits osteoclastogenesis by blocking RANKL-RANK interaction and suppressing the AKT, *MAPK, and NF-κB* signaling pathways .

Maohuoside A	TGF-β Receptor	Metabolic Disease
Maohuoside A, a single compound isolated from the E. koreanum that potently promotes osteogenesis. Maohuoside A enhances the osteogenesis of bone marrow-derived mesenchymal stem cells via bone morphogenetic protein (BMP) and MAPK signaling pathways .

DCOIT Kathon 930	GnRH Receptor	Endocrinology
DCOIT is a representative isothiazolinone that stimulates the gonadotropin-releasing hormone receptor (GnRHR)-mediated synthesis of follicle-stimulating hormone and luteinizing hormone in the brain. DCOIT interferes with G protein-coupled receptors, MAPK and Ca ²⁺ signaling cascades .

Murrayafoline A	NF-κB p38 MAPK	Neurological Disease Inflammation/Immunology
Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and *MAPK* signaling pathways. Murrayafoline A has anti-neuroinflammatory activity .

Crebanine 1 Publications Verification	Akt Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect .

AMC-04	Reactive Oxygen Species p38 MAPK	Cancer
AMC-04 is an unfolded protein response (UPR) activator, which activates UPR pathway through ROS and p38 MAPK signaling and induces apoptotic cell death. AMC-04 can be used for cancer research .

Diazepinomicin ECO-4601; TLN-4601; BU 4664L	Ras Apoptosis	Cancer
Diazepinomicin (TLN-4601) is a secondary metabolite produced by Micromonospora sp. Diazepinomicin (TLN-4601) inhibits the EGF-induced Ras-ERK MAPK signaling pathway and induces apoptosis. An anti-tumor agent for K-Ras mutant models .

Esculin sesquihydrate	p38 MAPK	Cancer
Esculin sesquihydrate, a fluorescent coumarin glucoside, is an active ingredient of ash bark. Esculin sesquihydrate ameliorates cognitive impairment in experimental diabetic nephropathy (DN), and exerts anti?oxidative stress and anti?inflammatory effects, via the *MAPK* signaling pathway .

Delphinidin chloride	Apoptosis EGFR JAK STAT	Cardiovascular Disease Cancer
Delphinidin chloride is an anthocyanin isolated from berries and red wine. Delphinidin chloride exhibits endothelium-dependent vasodilation and anticancer activity. Delphinidin chloride also modulates JAK/STAT3 and *MAPK* signaling, thereby inducing apoptosis in HCT116 cells. Delphinidin chloride is also a potent inhibitor of EGFR (IC₅₀: 1.3 μM), shutting down downstream signaling cascades .

Dehydromiltirone 1,2-Didehydromiltirone	NF-κB p38 MAPK	Inflammation/Immunology
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the *MAPK* and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research .

Asperuloside (Standard)	NO Synthase	Metabolic Disease Inflammation/Immunology
Asperuloside (Standard) is the analytical standard of Asperuloside. This product is intended for research and analytical applications. Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways .

Hederacoside C Kalopanaxsaponin B	Bacterial p38 MAPK NF-κB Apoptosis	Infection Inflammation/Immunology
Hederacoside C (Kalopanaxsaponin B) is an ingredient that can be obtained mainly from ivy leaves. Hederacoside C mediates inflammation by inhibiting activation of *MAPK/NF-κB* and its downstream signaling pathway. Hederacoside C has anti-inflammatory and antibacterial activity .

Armepavine	NF-κB	Inflammation/Immunology
Armepavine, an active compound from Nelumbo nucifera, exerts not only anti-inflammatory effects on human peripheral blood mononuclear cells, but also immunosuppressive effects on T lymphocytes and on lupus nephritic mice. Armepavine inhibits TNF-α-induced MAPK and NF-κB signaling cascades .

Deoxyelephantopin	NF-κB	Cancer
Deoxyelephantopin, a natural bioactive sesquiterpene lactone from Elephantopus scaber, has shown promising anticancer effects against a broad spectrum of cancers. Deoxyelephantopin inhibits NF-κB, *MAPK, PI3K/Akt, and β-catenin* signaling .

Gardenin A	ERK PAK	Neurological Disease Inflammation/Immunology
Gardenin A is an orally active and synthetic PMF analogue with the neurotrophic effect for neurite outgrowth and neuronal differentiation. Gardenin A promotes neuritogenesis via activating *MAPK/ERK, PKC, and PKA, but not TrkA, CREB signaling* pathways. Gardenin A also has sedative, anxiolytic, antidepressant, and anticonvulsant effects .

Anti-inflammatory agent 66	NF-κB p38 MAPK	Inflammation/Immunology
Anti-inflammatory agent 66 (compound 8) is a pterostilbene derivative with anti-inflammatory activity. Anti-inflammatory agent 66 inhibits pro-inflammatory cytokines by blocking the LPS-induced NF-κB/MAPK signaling pathway and effectively alleviates DSS-induced acute colitis in mice .

Anti-inflammatory agent 72	NF-κB Keap1-Nrf2 p38 MAPK	Inflammation/Immunology
Anti-inflammatory agent 72 (compound 5) is a novel resveratrol derivative hybrid with benzoylhydrazine. Anti-inflammatory agent 72 shows anti-inflammatory and antioxidant activities by activating Nrf2 and inhibiting NF-κB p65/iNOS and MAPKs signaling pathways .

Pestanoid A	ERK p38 MAPK JNK	Others
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC₅₀ of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .

Fumaric acid 1 Publications Verification	Endogenous Metabolite NF-κB p38 MAPK	Metabolic Disease Inflammation/Immunology
Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension .

Exarafenib RAF/KIN_2787	Raf p38 MAPK	Cancer
Exarafenib (RAF/KIN_2787) is an orally-available, selective pan-RAF inhibitor. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. Exarafenib has anticancer activity .

4'-Methoxyresveratrol 1 Publications Verification 4'-O-Methylresveratrol	NF-κB NOD-like Receptor (NLR)	Inflammation/Immunology
4'-Methoxyresveratrol (4'-O-Methylresveratrol) is a polyphenol derived from Dipterocarpaceae, with antiandrogenic, antifungal and anti-inflammatory activities. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation .

Sinigrin 1 Publications Verification	p38 MAPK AMPK	Metabolic Disease Inflammation/Immunology
Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Sinigrin inhibits early-stage adipogenesis of 3T3-L1 adipocytes through the AMPK and *MAPK* signaling pathways. Sinigrin has potent anti-oxidant, anti-tumor and anti-inflammatory effects .

TB22	Histone Methyltransferase	Cancer
TB22 is a non-nucleoside inhibitor of DOT1LR231Q, possessing anticancer activity. TB22 inhibits the malignant phenotype of lung cancer cells carrying the R231Q mutation through the *MAPK/ERK* signaling pathway, and can be used for lung cancer research .

Cat. No.	Product Name

HY-L010

MAPK Compound Library

569 compounds

MAPK families play an important role in complex cellular programs like proliferation, differentiation, development, transformation, and apoptosis. In mammalian cells, four MAPK families have been clearly characterized: ERK1/2, C-Jun N-terminal kinse/stress-activated protein kinase (JNK/SAPK) , p38 kinase and ERK5. They respond to different signals. Each MAPK-related cascade consists of three enzymes that are activated in series: a MAPK kinase kinase (MAPKKK), a MAPK kinase (MAPKK) and a MAP kinase (MAPK). MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers.

MCE designs a unique collection of 569 MAPK signaling pathway inhibitors that act as a useful tool for MAPK-related drug screening and disease research.

HY-L164

Serine/Threonine Kinase Inhibitor Library

1,371 compounds

Protein serine/threonine kinases (PSKs) are protein kinases that use ATP as a high-energy donor molecule to transfer phosphate groups to serine/threonine residues of target protein. As an important signal transduction regulator, serine/threonine kinases can affect the function of target proteins by disrupting enzyme activity or binding of target proteins to other proteins. Serine/threonine kinases are involved in the regulation of immune response, cell proliferation, differentiation, apoptosis and other physiological processes. Serine/threonine kinase inhibitors are an important class of compounds that have been widely studied in cancer, chronic inflammation, autoimmune diseases, aging and other diseases.

MCE designs a unique collection of 1,371 serine/threonine kinase inhibitors, mainly targeting the receptor PKA, Akt, PKC, MAPK/ERK, etc, which is an effective tool for development and research of anti-cancer, anti-chronic inflammatory diseases, anti-autoimmune diseases and anti-aging compounds.

HY-L045

Oxygen Sensing Compound Library

2,742 compounds

Oxygen homeostasis regulation is the most fundamental cellular process for adjusting physiological oxygen variations, and its irregularity leads to various human diseases, including cancer. Hypoxia is closely associated with cancer development, and hypoxia/oxygen-sensing signaling plays critical roles in the modulation of cancer progression.

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. A variety of HF-1 target genes have been identified thus far which encode proteins that play key roles in critical developmental and physiological processes including angiogenesis/vascular remodeling, erythropoiesis, glucose transport, glycolysis, iron transport, and cell proliferation/survival.

HIF-1 is a heterodimeric transcription factor consisting of a constitutively expressed β-subunit and an oxygen-regulated α-subunit. The unique feature of HIF-1 is the regulation of HIF-1α expression and activity based upon the cellular O₂ concentration. Under normoxic conditions, hydroxylation of HIF-1α on these different proline residues is essential for HIF proteolytic degradation by promoting interaction with the von Hippel-Lindau tumor-suppressor protein (pVHL) through hydrogen bonding to the hydroxyproline-binding pocket in the pVHL β-domain. As oxygen levels decrease, hydroxylation of HIF decreases; HIF-1α then no longer binds pVHL, and becomes stabilized, allowing more of the protein to translocate to the cell’s nucleus, where it acts as a transcription factor, upregulating (often within minutes) the production of proteins that stimulate blood perfusion in tissues and thus tissue oxygenation.

MCE offers a unique collection of 2,742 oxygen sensing related compounds targeting HIF/HIF Prolyl-Hydroxylase, MAPK/ERK, PI3K/AKT signaling pathways, etc. MCE Oxygen Sensing Compound Library is a useful tool to study hypoxia, oxidative stress and discover new anti-cancer drugs.

Cat. No.	Product Name	Target	Research Area

HY-P10436

Braftide	Raf	Cancer
Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF ^G469A with IC₅₀ of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC₅₀ is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence .

HY-P4322

H-Ile-Lys-Val-Ala-Val-OH 1 Publications Verification	ERK Akt	Neurological Disease Cancer
H-Ile-Lys-Val-Ala-Val-OH is one of the most potent active sites of laminin-1. H-Ile-Lys-Val-Ala-Val-OH promotes cell adhesion, neurite outgrowth, and tumor growth. H-Ile-Lys-Val-Ala-Val-OH stimulates BMMSC population growth and proliferation by activating *MAPK/ERK1/2* and PI3K/Akt signalling pathways .

HY-P10438

Tat-braftide	Raf	Cancer
Tat-braftide is a peptide inhibitor designed to block the dimerization of BRAF, thereby inhibiting its kinase activity. The destruction of BRAF dimer by Tat-braftide makes BRAF protein more susceptible to proteasome degradation, directly inhibits the activity of BRAF kinase, and reduces the activation of MAPK signaling pathway. Tat-braftide can be used for the role of RAF kinase in MAPK signaling pathway and for the study of BRAF mutant cancers .

HY-P2380

PAR3 (1-6) (human) TFRGAP	Protease Activated Receptor (PAR)	Inflammation/Immunology
PAR3 (1-6) is a synthetic peptide agonist of proteinase-activated receptor 1 (PAR1) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR3 and residues 39-44 of the full-length human sequence. PAR3 (1-6) activates p42/44 MAPK signaling in fibroblasts expressing PAR1, but not PAR3, an effect that can be blocked by the PAR1 antagonist RWJ 56110.

Cat. No.	Product Name	Chemical Structure

HY-14188S

Amiodarone-d4 hydrochloride

Amiodarone-d₄ (hydrochloride) is the deuterium labeled Amiodarone hydrochloride. Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].

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