iGluR

Ionotropic glutamate receptors

iGluR

iGluR Isoform Specific Products:

iGluR Isoform Comparison

iGluR Related Products (617)
Antibodies (11)
iGluR Isoform Comparison

By Effects:	Controls (2) Inhibitors (89) Agonists (92) Antagonists (279) Activators (28) Modulators (60) MDM2 Inhibitor (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-106968

ZD-9379	Antagonist
ZD-9379 is a potent, orally active, and brain penetrant full antagonist at the glycine site of the NMDA receptor. ZD-9379 has neuroprotective effect.

HY-124463

Epiallopregnanolone	Agonist
Epiallopregnanolone (5α,3β-THDOC), a 3β-hydroxy neurosteroid, an antagonist at GABAA receptors and a NMDA receptor enhancer.

HY-15076

SPD-502 sodium
SPD-502 sodium is a novel glutamate antagonist with potential neuroprotective properties, particularly in brain ischemia. It selectively targets the AMPA receptor, showing high affinity (IC₅₀ = 0.043 μM) and competitive inhibition of AMPA-induced effects in rat cortical membranes and cultured mouse cortical neurons. In vivo, SPD-502 sodium effectively blocks AMPA-evoked spike activity in the hippocampus after intravenous administration, significantly increasing the seizure threshold in mice and demonstrating robust protection against ischemia-induced damage to hippocampal neurons in gerbils. These findings suggest SPD-502 sodium may be promising for treating neurodegenerative conditions associated with glutamate excitotoxicity.

HY-168966

PDE2 inhibitor 6	Modulator
PDE2 inhibitor 6 (Compound 1) is the orally active inhibitor for phosphodiesterase (PDE) that inhibits PDE2A, PDE3B, and PDE10A2 with IC₅₀s of 0.95 nM, 6.17 μM (pIC₅₀=5.21) and 87.1 nM (pIC₅₀=7.06), respectively. PDE2 inhibitor 6 modulates the activity of AMPA receptor, enhance the synaptic plasticity and promotes the learning and memory function in rats models. PDE2 inhibitor 6 can cross blood-brain barrier.

HY-14608S10

L-Glutamic acid-¹³C₂
L-Glutamic acid-¹³C₂ is the ¹³C labeled L-Glutamic acid[1]. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals[2].

HY-15410

Gacyclidine	Antagonist
Gacyclidine, a non competitive N-methyl-D-aspartate (NMDA) antagonist, can be used in the study of spinal cord injuries.

HY-120524

CGP 31358
CGP 31358 is an anticonvulsant agent that binds to a site on the NMDA receptor complex that is coupled to both the transmitter recognition site and to the channel domain. CGP 31358 inhibits the binding of L-Glutamate to the NMDA receptor complex with an IC₅₀ of 53 μM.

HY-107710

LY 233053	Antagonist
LY 233053 is a potent and competitive NMDA-receptor antagonist with anticonvulsant and antiepileptic efficacy.

HY-118489

L644711	Inhibitor
L644711 is an anion transport inhibitor that reduces cell swelling by inhibiting potassium-activated D-aspartate release in astrocytes. L644711 can be used in the study of brain injury and neuroprotection.

HY-19435A

GYKI-47261 dihydrochloride	Antagonist
GYKI-47261 dihydrochloride is a competitive, orally active, and selective AMPA receptor antagonist with an IC₅₀ of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 dihydrochloride is also a potent inducer of CYP2E1.

HY-P10212

AVLX-125	Inhibitor
AVLX-125 (UCCB01-125) is a PSD-95 and PDZ domain inhibitor with K_d value of 10 nM. AVLX-125 can be used in the study of inflammatory pain.

HY-17387S1

(-)-Huperzine A-d₄ hydrochloride	Antagonist
(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.

HY-110234R

Topiramate D12 (Standard)	Antagonist
Topiramate D12 (Standard) is the analytical standard of Topiramate D12. This product is intended for research and analytical applications. Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.

HY-W018061A

Traxoprodil mesylate	Antagonist
Traxoprodil mesylate (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC₅₀ of 10 nM.

HY-107518

(R,S)-3,4-Dicarboxyphenylglycine	Antagonist
(R,S)-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) is an AMPA receptor antagonist. (R,S)-3,4-Dicarboxyphenylglycine antagonizes AMPA-mediated depolarization of motor neurons in neonatal rats. (R,S)-3,4-Dicarboxyphenylglycine can be used in the study of neurological diseases.

HY-19435

GYKI-47261	Antagonist
GYKI-47261 is a competitive, orally active, and selective AMPA receptor antagonist with an IC₅₀ of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 is also a potent inducer of CYP2E1.

HY-N0215S6

DL-Phenylalanine-d₅ hydrochloride	Antagonist
DL-Phenylalanine-d₅ (hydrochloride) is the deuterium labeled DL-Phenylalanine hydrochloride. L-Phenylalanine hydrochloride is an essential amino acid isolated from Escherichia coli. L-Phenylalanine hydrochloride is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine hydrochloride is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine hydrochloride is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-B0369AS

Orphenadrine-d₃ citrate	Antagonist
Orphenadrine-d₃ (citrate) is the deuterium labeled Orphenadrine citrate. Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

HY-168494

GluN2A Allosteric modulator 1	Antagonist
GluN2A Allosteric modulator 1 (Compound 11) is an orally active, BBB-penatrable and highly selective GluN2A negative allosteric modulator. GluN2A Allosteric modulator 1 has IC₅₀ values of 0.042 μM and 13 μM for GluN2A and GluN2B, respectively. GluN2A Allosteric modulator 1 can be used for the research of nervous system diseases.

HY-125931

Unifiram	Activator	99.78%
Unifiram (DM232) is acts as a potent cognition enhancer through the activation of the AMPA-mediated neurotransmission system. Unifiram (DM232) has the potential for amnesia prevention and neurodegenerative disorder research.

Dizocilpine maleate	NMDA Receptor		99.99%
D-AP5	NMDA Receptor		99.94%
EMD-95885	NR2B, IC₅₀: 3.9 nM		98.74%
NMDA	NMDA Receptor		99.73%
Glycine	NMDA Receptor		99.93%
L-Phenylalanine	NMDA Receptor		99.98%
CNQX		Kainate Receptor	99.65%
Kynurenic acid	NMDA Receptor		99.21%
Quinolinic acid	NMDA Receptor		99.85%
Cycloleucine	NMDA Receptor		≥98.0%
DL-AP5	NMDA Receptor		≥98.0%
D-Cycloserine	NMDA Receptor		98.28%
Dizocilpine	NMDA Receptor		99.90%
Ifenprodil tartrate	NMDA Receptor		99.95%
DNQX		Kainate Receptor	99.26%
L-Phenylalanine-d₅	NMDA Receptor		99.90%
Topiramate		Kainate Receptor	≥98.0%
Bupivacaine	NMDA Receptor		99.96%
24-Hydroxycholesterol	NMDA Receptor		99.90%
Quinolinic acid-d₃	NMDA Receptor		99.90%
Ibotenic acid	NMDA Receptor		99.0%
D-Serine	NMDA Receptor		≥98.0%
Bupivacaine hydrochloride	NMDA Receptor		99.85%
Crocetin	NMDA Receptor		98.22%
Ro 25-6981 Maleate	NMDA Receptor		99.25%
(-)-Huperzine A	NMDA Receptor		99.74%
PEAQX tetrasodium hydrate	NMDA Receptor		≥98.0%
Flupirtine Maleate	NMDA Receptor		99.97%
Kynurenic acid-d₅	NMDA Receptor		98.35%
Diphenhydramine	NMDA Receptor, IC₅₀: 24.6 μM		99.42%
Tacrine hydrochloride	NMDA Receptor		99.95%
Traxoprodil	NMDA Receptor		99.88%
Linalool	NMDA Receptor		98.55%
Tat-NR2B9c	NMDA Receptor		99.97%
CNQX disodium		Kainate Receptor	99.95%
MDL-29951	NMDA Receptor		99.17%
Kynurenic acid sodium	NMDA Receptor		99.79%
24(S)-Hydroxycholesterol	NMDA Receptor		99.55%
MDL 105519	NMDA Receptor		99.67%
7-Chlorokynurenic acid	NMDA Receptor		99.86%
GNE 5729	NMDA Receptor		99.50%
ZL006	NMDA Receptor		99.23%
Indole-2-carboxylic acid	NMDA Receptor		99.86%
5,7-Dichlorokynurenic acid	NMDA Receptor		99.98%
Orphenadrine citrate	NMDA Receptor, Ki: 6 μM		99.41%
Glycine-d₅	NMDA Receptor		≥99.0%
Glycine-d₂	NMDA Receptor		≥99.0%
Rapastinel Trifluoroacetate	NMDA Receptor		≥98.0%
L-Phenylalanine-d₈	NMDA Receptor		99.62%
Felbamate	NMDA Receptor		99.27%
TCN 201	NMDA Receptor		99.06%
GYKI 52466 dihydrochloride		Kainate Receptor, IC₅₀: 11 μM	99.75%
Glycine-¹³C₂	NMDA Receptor		99.10%
SYM 2081		Kainate Receptor	≥98.0%
L-Glutamic acid-¹⁵N	NMDA Receptor		≥98.0%
Fluoroethylnormemantine	NMDA Receptor		≥98.0%
7-Chlorokynurenic acid sodium salt	NMDA Receptor		99.79%
CIQ	NMDA Receptor		99.75%
(Rac)-Lanicemine	NMDA Receptor		99.63%
L-Glutamic acid-¹³C₅	NMDA Receptor		≥98.0%
Isoxsuprine hydrochloride	NMDA Receptor		99.95%
Procyclidine hydrochloride	NMDA Receptor		99.55%
Glycine-¹⁵N	NMDA Receptor		≥98.0%
Glycine-1-¹³C	NMDA Receptor		99.4%
Dynorphin A (1-10) (TFA)	NMDA Receptor
L-Phenylalanine-¹³C₆	NMDA Receptor		≥99.0%
Crocetin disodium	NMDA Receptor		98.00%
IC87201	NMDA Receptor
Ro 25-6981	NMDA Receptor		99.55%
L-701324	NMDA Receptor		99.85%
Glycine-2-¹³C	NMDA Receptor		99.3%
L-Phenylalanine-d₂	NMDA Receptor		99.00%
Nefiracetam	NMDA Receptor		99.91%
Glycine-¹³C₂,¹⁵N	NMDA Receptor		≥99.0%
Zelquistinel	NMDA Receptor		99.78%
Pulchinenoside A	NMDA Receptor		≥98.0%
L-Phenylalanine-3-¹³C	NMDA Receptor		99.48%
Nelonemdaz	NMDA Receptor		99.84%
Tat-NR2B9c TFA	NMDA Receptor		99.67%
L-Phenylalanine-¹³C₉	NMDA Receptor		98.09%
Lanicemine dihydrochloride	NMDA Receptor		99.94%
Plazinemdor	NMDA Receptor
Flupirtine	NMDA Receptor		99.98%
Nelonemdaz potassium	NMDA Receptor		99.86%
NYX-2925	NMDA Receptor		98.77%
L-Phenylalanine-¹³C₉,¹⁵N	NMDA Receptor		99.52%
QNZ46	NMDA Receptor		99.46%
Perzinfotel	NMDA Receptor		99.43%
Eliprodil	NMDA Receptor		99.43%
SDZ 220-581	NMDA Receptor		99.20%
CGP 78608 hydrochloride	NMDA Receptor		99.56%
Crocetin meglumine	NMDA Receptor		98.17%
(R)-CPP	NMDA Receptor		98.99%
Mephenesin	NMDA Receptor		99.69%
Bupivacaine-d₉	NMDA Receptor		99.04%
L-Phenylalanine-¹³C	NMDA Receptor		99.66%
Budipine	NMDA Receptor		99.41%
L-Phenylalanine-¹⁵N,d₈	NMDA Receptor		99.90%
L-Homocysteic acid	NMDA Receptor, EC₅₀: 14 μM		≥98.0%
(S)-Willardiine		Kainate Receptor	98.93%
6-Methoxy-2-naphthoic acid	NMDA Receptor		99.73%
GNE-0723	NMDA Receptor		98.74%
Aptiganel hydrochloride	NMDA Receptor		99.80%
4-PPBP maleate	NMDA Receptor		99.63%
Gavestinel sodium salt	NMDA Receptor		99.38%
Brophenexin free base	NMDA Receptor		99.24%
Tat-NR2Baa	NMDA Receptor
L-701252	NMDA Receptor		99.86%
Isoxsuprine-d₆ hydrochloride	NMDA Receptor		99.73%
Withanone	NMDA Receptor
Felbamate-d₄	NMDA Receptor		99.00%
PEAQX	NMDA Receptor
Remacemide	NMDA Receptor
L-Phenylalanine-d₇	NMDA Receptor		99.90%
Fluoroethylnormemantine hydrochloride	NMDA Receptor		≥98.0%
Lanicemine	NMDA Receptor		≥99.0%
CGP 37849	NMDA Receptor		≥99.0%
(RS)-(Tetrazol-5-yl)glycine	NMDA Receptor
L-Glutamic acid-1-¹³C	NMDA Receptor		≥99.0%
Topiramate D12		Kainate Receptor	99.90%
UBP608	NMDA Receptor		99.60%
TCN 213	NMDA Receptor		99.16%
L-689560	NMDA Receptor		≥99.0%
MRZ 2-514	NMDA Receptor
(S)-(-)-HA 966	NMDA Receptor		≥98.0%
MPX-004	NMDA Receptor		99.58%
1-Aminocyclobutanecarboxylic acid	NMDA Receptor		≥98.0%
Orphenadrine hydrochloride	NMDA Receptor, Ki: 6 μM
NMDA receptor antagonist 2	NMDA Receptor
DL-AP5 sodium	NMDA Receptor		99.20%
Midafotel	NMDA Receptor, : 39 nM		99.00%
D-Cycloserine (Standard)	NMDA Receptor
Delucemine	NMDA Receptor
GYKI 52466		Kainate Receptor, IC₅₀: 11 μM
Glycine-¹⁵N,d₂	NMDA Receptor
NMDA agonist 2	NR2C, EC₅₀: 0.034 μM
Ro 04-5595 hydrochloride	GluN2B, Ki: 31 nM
(3S,6R)-NML	GluN2A, IC₅₀: 15.8 μM GluN2B, IC₅₀: 25.1 μM NR2C, IC₅₀: 10 μM NR2D, IC₅₀: 10 μM
PMPA (NMDA antagonist)	NMDA Receptor
NMDAR/HDAC-IN-1	NMDA Receptor, Ki: 0.59 μM
Linalool (Standard)	NMDA Receptor
(R)-(+)-HA-966	NMDA Receptor		98.85%
L-Phenylalanine-d	NMDA Receptor
HSD17B13-IN-7	NR2B
YY-23	NMDA Receptor
Glycine-d₃	NMDA Receptor
L-Cysteine S-sulfate	NMDA Receptor
L-Glutamic acid-¹³C	NMDA Receptor
L-Phenylalanine-¹³C₉,¹⁵N,d₈	NMDA Receptor
NMDA receptor potentiator-1	NR2C, IC₅₀: 4 μM NR2D, IC₅₀: 5 μM
Bupivacaine (hydrochloride) (Standard)	NMDA Receptor		99.99%
Indole-2-carboxylic acid-¹³C	NMDA Receptor
NMDA agonist 1	NMDA Receptor, Ki: 96 nM
NMDA receptor antagonist-3	NMDA Receptor
UK-240455	NMDA Receptor
Glycine-2-¹³C,¹⁵N	NMDA Receptor		≥98.0%
L-Glutamic acid-5-¹³C	NMDA Receptor
L-AP5	NMDA Receptor
Bupivacaine hydrochloride monohydrate	NMDA Receptor
cis-ACPD	NMDA Receptor, IC₅₀: 3.3 μM
NMDA receptor antagonist 5	NMDA Receptor
Dynorphin A (1-10)	NMDA Receptor
GluN2B-NMDAR antagonist-2	GluN2B, IC₅₀: 74.01 nM
Conantokin G	NMDA Receptor
DL-AP7	NMDA Receptor
Tat-NR2Baa TFA	NMDA Receptor
Procyclidine	NMDA Receptor
GV-196771A	NMDA Receptor
CGP 31358	NMDA Receptor
LY 233053	NMDA Receptor
Orphenadrine-d₃ citrate	NMDA Receptor
GluN2A Allosteric modulator 1	GluN2A, IC₅₀: 0.042 μM GluN2B, IC₅₀: 13 μM
Flupirtine-d4 hydrochloride	NMDA Receptor
GNE 6901	GluN2A, EC₅₀: 382 nM
NMDAR antagonist 5	NMDA Receptor, IC₅₀: 0.3 μM
Antidepressant agent 8	NMDA Receptor, IC₅₀: 2.94 μg/mL
Glycine-1-¹³C,¹⁵N	NMDA Receptor		99.5%
DL-AP5 lithium	NMDA Receptor
Delucemine hydrochloride	NMDA Receptor
NMDAR antagonist 3	NR2B
Nefiracetam (Standard)	NMDA Receptor

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iGluR

iGluR

iGluR Isoform Specific Products:

iGluR Isoform Specific Products:

iGluR Related Products (617)

Antibodies (11)

iGluR Isoform Comparison

iGluR Related Products (617):