iGluR

Ionotropic glutamate receptors

iGluR

iGluR Isoform Specific Products:

iGluR Isoform Comparison

iGluR Related Products (604)
Antibodies (11)
iGluR Isoform Comparison

By Effects:	Controls (2) Ligand (1) Inhibitors (89) Agonists (92) Antagonists (273) Activators (19) Modulators (60) MDM2 Inhibitor (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-107518

(R,S)-3,4-Dicarboxyphenylglycine	Antagonist
(R,S)-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) is an AMPA receptor antagonist. (R,S)-3,4-Dicarboxyphenylglycine antagonizes AMPA-mediated depolarization of motor neurons in neonatal rats. (R,S)-3,4-Dicarboxyphenylglycine can be used in the study of neurological diseases.

HY-19435

GYKI-47261	Antagonist
GYKI-47261 is a competitive, orally active, and selective AMPA receptor antagonist with an IC₅₀ of 2.5 μM. GYKI-47261 has broad spectrum anticonvulsive activity and neuroprotective effects. GYKI-47261 is also a potent inducer of CYP2E1.

HY-N0215S6

DL-Phenylalanine-d₅ hydrochloride	Antagonist
DL-Phenylalanine-d₅ (hydrochloride) is the deuterium labeled DL-Phenylalanine hydrochloride. L-Phenylalanine hydrochloride is an essential amino acid isolated from Escherichia coli. L-Phenylalanine hydrochloride is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine hydrochloride is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine hydrochloride is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-B0369AS

Orphenadrine-d₃ citrate	Antagonist
Orphenadrine-d₃ (citrate) is the deuterium labeled Orphenadrine citrate. Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

HY-168494

GluN2A Allosteric modulator 1	Antagonist
GluN2A Allosteric modulator 1 (Compound 11) is an orally active, BBB-penatrable and highly selective GluN2A negative allosteric modulator. GluN2A Allosteric modulator 1 has IC₅₀ values of 0.042 μM and 13 μM for GluN2A and GluN2B, respectively. GluN2A Allosteric modulator 1 can be used for the research of nervous system diseases.

HY-125931

Unifiram	Activator	99.78%
Unifiram (DM232) is acts as a potent cognition enhancer through the activation of the AMPA-mediated neurotransmission system. Unifiram (DM232) has the potential for amnesia prevention and neurodegenerative disorder research.

HY-110230

Flupirtine-d4 hydrochloride	Antagonist
Flupirtine-d4 (D 9998-d4) hydrochloride is the deuterium labeled Flupirtine. Flupirtine(D 9998) hydrochloride is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties.

HY-159584

LBG20304	Inhibitor
LBG20304 (compound 2s) is a ligand for the homologous GluK5 receptor (IC₅₀: 432 nM), more than 40-fold selective over the homologous GluK1-3 isoforms. Low doses of LBG20304 (<10 μM) have no agonist or antagonist functional response at heterologous GluK2/5 receptors, and at high doses (>10 μM), it exhibits low agonist activity in neuronal slices (rat).

HY-107519

(R)-3,4-DCPG	Antagonist
(R)-3,4-DCPG is an AMPA and NMDA antagonist with a K_d of 77 μM for AMPA. (R)-3,4-DCPG complete antagonizes the NMDA-induced depolarization at a concentration of 500 μM. (R)-3,4-DCPG exhibits a weak antagonistic effect on kainate-induced depolarizations.

HY-149975

AMPA receptor modulator-4	Activator
AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). AMPA receptor modulator-4 can cross the blood-brain barrier. AMPA receptor modulator-4 increases the cognition performance and improves working memory performance in mice.

HY-B0184R

Felbamate (Standard)	Inhibitor
Felbamate (Standard) is the analytical standard of Felbamate. This product is intended for research and analytical applications. Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA).

HY-15074

SPD-502
SPD-502 is a novel glutamate antagonist with potential neuroprotective properties, particularly in brain ischemia. It selectively targets the AMPA receptor, showing high affinity (IC₅₀ = 0.043 μM) and competitive inhibition of AMPA-induced effects in rat cortical membranes and cultured mouse cortical neurons. In vivo, SPD-502 effectively blocks AMPA-evoked spike activity in the hippocampus after intravenous administration, significantly increasing the seizure threshold in mice and demonstrating robust protection against ischemia-induced damage to hippocampal neurons in gerbils. These findings suggest SPD-502 may be promising for treating neurodegenerative conditions associated with glutamate excitotoxicity.

HY-P1195A

PDZ1 Domain inhibitor peptide TFA
PDZ1 Domain inhibitor peptide TFA, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide TFA disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain.

HY-14608S9

L-Glutamic acid-¹⁵N,d₅	Agonist
L-Glutamic acid-¹⁵N,d₅ is the deuterium and ¹⁵N-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

HY-W835175

Neramexane hydrochloride	Antagonist
Neramexane hydrochloride is an oral N-methyl-D-aspartate (NMDA) receptor antagonist, as a potential neuroprotectant for various central nervous system disorders, including Alzheimer's disease, and for the potential treatment of drug and alcohol dependence, and pain.

HY-U00199A

(S)-Norzopiclone	Inhibitor
(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of the GABA_A receptor and inhibits nACh and NMDA receptors.

HY-101440A

Indantadol hydrochloride
Indantadol (CHF-3381) hydrochloride is a novel putative NMDA antagonist. Indantadol blocks the NMDA receptor in a dose-dependent and prevents cell damage.

HY-B1126S

Orphenadrine-d₃ hydrochloride
Orphenadrine-d₃ (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride[1]. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[2][3].

HY-119886

BMS-986169	Inhibitor
BMS-986169 is an inhibitor of the glutamate N-methyl-D-aspartate 2B receptor (GluN2B). BMS-986169 has a high binding affinity for the allosteric regulatory site of the GluN2B subunit, with a K_i value of 4.03-6.3 nM. BMS-986169 can inhibit the function of GluN2B receptors in Xenopus oocytes, with an IC₅₀ value of 24.1 nM. BMS-986169 can also inhibit the activity of the hERG channel, with an IC₅₀ value of 28.4 μM. BMS-986169 can be used in research on treatment-resistant depression.

HY-148939

MPX-004	Antagonist
MPX-004 is a potent GluN2A antagonist. MPX-004 inhibits GluN2A-containing NMDA receptors expressed in HEK cells with an IC₅₀ of 79 nM. MPX-004 has no inhibitory effect on GluN2B or GluN2D receptor-mediated responses. MPX-004 has the potential for neuropsychiatric and developmental disorders research.

Dizocilpine maleate	NMDA Receptor		99.99%
D-AP5	NMDA Receptor		99.94%
EMD-95885	NR2B, IC₅₀: 3.9 nM		98.74%
NMDA	NMDA Receptor		99.73%
Glycine	NMDA Receptor		99.93%
L-Phenylalanine	NMDA Receptor		99.98%
CNQX		Kainate Receptor	99.65%
Kynurenic acid	NMDA Receptor		99.21%
Quinolinic acid	NMDA Receptor		99.85%
Cycloleucine	NMDA Receptor		≥98.0%
D-Cycloserine	NMDA Receptor		99.97%
DL-AP5	NMDA Receptor		≥98.0%
Ifenprodil tartrate	NMDA Receptor		99.95%
DNQX		Kainate Receptor	99.26%
Dizocilpine	NMDA Receptor		99.90%
L-Phenylalanine-d₅	NMDA Receptor		99.90%
Topiramate		Kainate Receptor	≥98.0%
Bupivacaine	NMDA Receptor		99.96%
24-Hydroxycholesterol	NMDA Receptor		99.90%
Quinolinic acid-d₃	NMDA Receptor		99.90%
D-Serine	NMDA Receptor		≥98.0%
Ibotenic acid	NMDA Receptor		99.0%
Bupivacaine hydrochloride	NMDA Receptor		99.89%
Crocetin	NMDA Receptor		98.22%
Ro 25-6981 Maleate	NMDA Receptor		99.25%
PEAQX tetrasodium hydrate	NMDA Receptor		≥98.0%
(-)-Huperzine A	NMDA Receptor		99.74%
Flupirtine Maleate	NMDA Receptor		99.97%
Kynurenic acid-d₅	NMDA Receptor		98.35%
Tacrine hydrochloride	NMDA Receptor		99.95%
Diphenhydramine	NMDA Receptor, IC₅₀: 24.6 μM		99.08%
Traxoprodil	NMDA Receptor		99.88%
Linalool	NMDA Receptor		98.55%
Tat-NR2B9c	NMDA Receptor		99.97%
MDL-29951	NMDA Receptor		99.17%
Kynurenic acid sodium	NMDA Receptor		99.79%
CNQX disodium		Kainate Receptor	99.95%
MDL 105519	NMDA Receptor		99.67%
GNE 5729	NMDA Receptor		99.50%
ZL006	NMDA Receptor		99.23%
24(S)-Hydroxycholesterol	NMDA Receptor		99.55%
7-Chlorokynurenic acid	NMDA Receptor		99.86%
Indole-2-carboxylic acid	NMDA Receptor		99.86%
Orphenadrine citrate	NMDA Receptor, Ki: 6 μM		99.41%
Glycine-d₅	NMDA Receptor		≥99.0%
Rapastinel Trifluoroacetate	NMDA Receptor		≥98.0%
L-Phenylalanine-d₈	NMDA Receptor		99.62%
Glycine-d₂	NMDA Receptor		≥99.0%
Felbamate	NMDA Receptor		99.27%
TCN 201	NMDA Receptor		99.06%
GYKI 52466 dihydrochloride		Kainate Receptor, IC₅₀: 11 μM	99.75%
Glycine-¹³C₂	NMDA Receptor		99.10%
SYM 2081		Kainate Receptor	≥98.0%
5,7-Dichlorokynurenic acid	NMDA Receptor		99.91%
L-Glutamic acid-¹⁵N	NMDA Receptor		≥98.0%
Fluoroethylnormemantine	NMDA Receptor		≥98.0%
7-Chlorokynurenic acid sodium salt	NMDA Receptor		99.79%
CIQ	NMDA Receptor		99.75%
(Rac)-Lanicemine	NMDA Receptor		99.63%
L-Glutamic acid-¹³C₅	NMDA Receptor		≥98.0%
Isoxsuprine hydrochloride	NMDA Receptor		99.95%
Procyclidine hydrochloride	NMDA Receptor		99.55%
Glycine-1-¹³C	NMDA Receptor		99.4%
Dynorphin A (1-10) (TFA)	NMDA Receptor
Glycine-¹⁵N	NMDA Receptor		≥98.0%
Crocetin disodium	NMDA Receptor		98.00%
L-Phenylalanine-¹³C₆	NMDA Receptor		≥99.0%
IC87201	NMDA Receptor
L-701324	NMDA Receptor		99.85%
Glycine-2-¹³C	NMDA Receptor		99.3%
L-Phenylalanine-d₂	NMDA Receptor		99.00%
Nefiracetam	NMDA Receptor		99.91%
Pulchinenoside A	NMDA Receptor		≥98.0%
Ro 25-6981	NMDA Receptor		99.55%
L-Phenylalanine-3-¹³C	NMDA Receptor		99.48%
Nelonemdaz	NMDA Receptor		99.84%
Tat-NR2B9c TFA	NMDA Receptor		99.67%
Glycine-¹³C₂,¹⁵N	NMDA Receptor		≥99.0%
L-Phenylalanine-¹³C₉	NMDA Receptor		98.09%
Plazinemdor	NMDA Receptor
Lanicemine dihydrochloride	NMDA Receptor		99.94%
Flupirtine	NMDA Receptor		99.98%
Nelonemdaz potassium	NMDA Receptor		99.86%
NYX-2925	NMDA Receptor		98.77%
L-Phenylalanine-¹³C₉,¹⁵N	NMDA Receptor		99.52%
QNZ46	NMDA Receptor		99.46%
Perzinfotel	NMDA Receptor		99.43%
Eliprodil	NMDA Receptor		99.43%
SDZ 220-581	NMDA Receptor		99.20%
CGP 78608 hydrochloride	NMDA Receptor		99.56%
Crocetin meglumine	NMDA Receptor		98.17%
Mephenesin	NMDA Receptor		99.69%
Bupivacaine-d₉	NMDA Receptor		99.04%
L-Phenylalanine-¹³C	NMDA Receptor		99.66%
Budipine	NMDA Receptor		99.41%
L-Phenylalanine-¹⁵N,d₈	NMDA Receptor		99.90%
L-Homocysteic acid	NMDA Receptor, EC₅₀: 14 μM		≥98.0%
(S)-Willardiine		Kainate Receptor	98.93%
6-Methoxy-2-naphthoic acid	NMDA Receptor		99.73%
(R)-CPP	NMDA Receptor		98.99%
GNE-0723	NMDA Receptor		98.74%
Aptiganel hydrochloride	NMDA Receptor		99.80%
4-PPBP maleate	NMDA Receptor		99.63%
Brophenexin free base	NMDA Receptor		99.24%
Tat-NR2Baa	NMDA Receptor
L-701252	NMDA Receptor		99.86%
Isoxsuprine-d₆ hydrochloride	NMDA Receptor		99.73%
Withanone	NMDA Receptor
Felbamate-d₄	NMDA Receptor		99.00%
PEAQX	NMDA Receptor
Remacemide	NMDA Receptor
L-Phenylalanine-d₇	NMDA Receptor		99.90%
Fluoroethylnormemantine hydrochloride	NMDA Receptor		≥98.0%
Lanicemine	NMDA Receptor		≥99.0%
CGP 37849	NMDA Receptor		≥99.0%
Gavestinel sodium salt	NMDA Receptor		99.38%
(RS)-(Tetrazol-5-yl)glycine	NMDA Receptor
L-Glutamic acid-1-¹³C	NMDA Receptor		≥99.0%
Topiramate D12		Kainate Receptor	99.90%
UBP608	NMDA Receptor		99.60%
TCN 213	NMDA Receptor		99.16%
L-689560	NMDA Receptor		≥99.0%
MRZ 2-514	NMDA Receptor
(S)-(-)-HA 966	NMDA Receptor		≥98.0%
1-Aminocyclobutanecarboxylic acid	NMDA Receptor		≥98.0%
Orphenadrine hydrochloride	NMDA Receptor, Ki: 6 μM
NMDA receptor antagonist 2	NMDA Receptor
DL-AP5 sodium	NMDA Receptor		99.20%
Midafotel	NMDA Receptor, : 39 nM		99.00%
D-Cycloserine (Standard)	NMDA Receptor
Delucemine	NMDA Receptor
GYKI 52466		Kainate Receptor, IC₅₀: 11 μM
Glycine-¹⁵N,d₂	NMDA Receptor
NMDA agonist 2	NR2C, EC₅₀: 0.034 μM
Ro 04-5595 hydrochloride	GluN2B, Ki: 31 nM
(3S,6R)-NML	GluN2A, IC₅₀: 15.8 μM GluN2B, IC₅₀: 25.1 μM NR2C, IC₅₀: 10 μM NR2D, IC₅₀: 10 μM
PMPA (NMDA antagonist)	NMDA Receptor
NMDAR/HDAC-IN-1	NMDA Receptor, Ki: 0.59 μM
Linalool (Standard)	NMDA Receptor
Analgesic/antidepressant agent-1	NMDA Receptor
(R)-(+)-HA-966	NMDA Receptor		98.85%
L-Phenylalanine-d	NMDA Receptor
HSD17B13-IN-7	NR2B
YY-23	NMDA Receptor
Glycine-d₃	NMDA Receptor
L-Cysteine S-sulfate	NMDA Receptor
L-Glutamic acid-¹³C	NMDA Receptor
L-Phenylalanine-¹³C₉,¹⁵N,d₈	NMDA Receptor
NMDA receptor potentiator-1	NR2C, IC₅₀: 4 μM NR2D, IC₅₀: 5 μM
Bupivacaine (hydrochloride) (Standard)	NMDA Receptor		99.99%
Indole-2-carboxylic acid-¹³C	NMDA Receptor
NMDA agonist 1	NMDA Receptor, Ki: 96 nM
NMDA receptor antagonist-3	NMDA Receptor
UK-240455	NMDA Receptor
Glycine-2-¹³C,¹⁵N	NMDA Receptor		≥98.0%
L-Glutamic acid-5-¹³C	NMDA Receptor
L-AP5	NMDA Receptor
Bupivacaine hydrochloride monohydrate	NMDA Receptor
cis-ACPD	NMDA Receptor, IC₅₀: 3.3 μM
NMDA receptor antagonist 5	NMDA Receptor
Dynorphin A (1-10)	NMDA Receptor
GluN2B-NMDAR antagonist-2	GluN2B, IC₅₀: 74.01 nM
Conantokin G	NMDA Receptor
DL-AP7	NMDA Receptor
Tat-NR2Baa TFA	NMDA Receptor
Procyclidine	NMDA Receptor
GV-196771A	NMDA Receptor
CGP 31358	NMDA Receptor
LY 233053	NMDA Receptor
Orphenadrine-d₃ citrate	NMDA Receptor
GluN2A Allosteric modulator 1	GluN2A, IC₅₀: 0.042 μM GluN2B, IC₅₀: 13 μM
Flupirtine-d4 hydrochloride	NMDA Receptor
MPX-004	NMDA Receptor
GNE 6901	GluN2A, EC₅₀: 382 nM
Antidepressant agent 8	NMDA Receptor, IC₅₀: 2.94 μg/mL
Glycine-1-¹³C,¹⁵N	NMDA Receptor		99.5%
DL-AP5 lithium	NMDA Receptor
Delucemine hydrochloride	NMDA Receptor
NMDAR antagonist 3	NR2B
Nefiracetam (Standard)	NMDA Receptor

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iGluR

iGluR

iGluR Isoform Specific Products:

iGluR Isoform Specific Products:

iGluR Related Products (604)

Antibodies (11)

iGluR Isoform Comparison

iGluR Related Products (604):