Search Result

Results for "

IPK Superfamily

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) c-Met/HGFR (1) CD276/B7-H3 (1) CGRP Receptor (1) CRFR (1) Endogenous Metabolite (1) Fluorescent Dye (1) Glutathione Peroxidase (1) Interleukin Related (1) Orexin Receptor (OX Receptor) (1) Orphan Receptor (1) Phospholipase (3) PPAR (2) Ras (4) TGF-beta/Smad (2) TGF-β Receptor (1) TNF Receptor (3)
By Research Areas:	Cancer (16) Cardiovascular Disease (3) Endocrinology (2) Infection (1) Inflammation/Immunology (9) Metabolic Disease (5) Neurological Disease (2)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

254

Recombinant Proteins

Antibodies

Targets Recommended: IPK Superfamily

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145915A

(E/Z)-ZINC09659342	Ras	Cancer
(E/Z)-ZINC09659342 is an inhibitor of Lbc-RhoA interaction .

HY-D0091

7-Ethoxy-4-trifluoromethylcoumarin	Fluorescent Dye	Others
7-Ethoxy-4-trifluoromethylcoumarin is a fluorescent substrate of various enzymes of the cytochrome P450 superfamily

HY-P99393

Tavolixizumab MEDI 0562; Tavolimab	TNF Receptor	Cancer
Tavolixizumab (MEDI 0562; Tavolimab) is a human monoclonal antibody to TNFRSF4 (TNF receptor superfamily member 4) for use in cancer immunology research .

HY-78349

A 77-01 1 Publications Verification	TGF-β Receptor	Cancer
A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC₅₀ of 25 nM .

HY-145197

MPO-IN-3	Glutathione Peroxidase	Cardiovascular Disease
MPO-IN-3 is a potent myeloperoxidase (MPO) inhibitor (WO2013068875A1, example 191). Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the peroxidase superfamily .

HY-135542

NBI-27914	CRFR	Others
NBI-27914 is a potent and selective antagonist of CRFR1. The CRF receptors, CRFR1 and CRFR2, are members of the G protein-coupled receptor superfamily .

HY-112473

NAV-2729 Maximum Cited Publications 6 Publications Verification	Ras Others	Cancer
NAV-2729 is a dual Arf1/Arf6 activation inhibitor. ADP ribosylation factors (Arfs) are members of the Arf family of GTP-binding proteins of the Ras superfamily.

HY-133122

UCB-9260	TNF Receptor	Inflammation/Immunology Cancer
UCB-9260, an orally active compound, inhibits TNF signaling by stabilising an asymmetric form of the trimer.?UCB-9260 is selective for TNF over other superfamily members, and binds TNF with a similar?K_d?of 13?nM .

HY-145915

ZINC09659342	Ras	Cancer
ZINC09659342 (compound 13) is an inhibitor of Lbc-RhoA interaction with an IC₅₀ of 3.6 μΜ .

HY-P2736

Amidase	Endogenous Metabolite	Metabolic Disease
Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes .

HY-P3919

Adrenotensin (human) Pro-ADM-153-185 (human)	CGRP Receptor	Cardiovascular Disease
Adrenotensin (human) (Pro-ADM-153-185 (human)) is a 153-185 fragment of precursor peptide of Adrenomedullin. Adrenomedullin (ADM) is a 52-amino acid multifunctional peptide, which belongs to the CGRP superfamily of vasoactive peptide hormones .

HY-P99945

Revdofilimab ABBV-368	Orexin Receptor (OX Receptor)	Inflammation/Immunology Cancer
Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells .

HY-P990720

Elritercept KER-050	TGF-beta/Smad	Inflammation/Immunology
Elritercept (KER-050) is a recombinant fusion protein comprising a modified activin receptor type IIA extracellular domain fused to a human IgG1 Fc. Elritercept inhibits activin A and other select TGF-β superfamily ligands .

HY-125017

Bozitinib 1 Publications Verification PLB-1001; CBT-101; Vebreltinib	c-Met/HGFR	Cancer
Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily .

HY-P990070

Zigakibart BION-1301	TNF Receptor	Inflammation/Immunology Cancer
Zigakibart (BION-1301) is an IgG4-kappa, anti-TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256) humanized monoclonal antibody. Zigakibart shows anti-inflammatory activity .

HY-170327

ZCL279	Ras	Cancer
ZCL279 is a small molecule modulator (SMM) that inhibits Cdc42-intersectin (ITSN) interaction. ZCL279 can activate Cdc42 (a cytoplasmic small GTPase in the Ras superfamily) at lower concentrations (<10 μM) and significantly inhibit it at higher concentrations (<10 μM) .

HY-E70022

D-Mannose isomerase (PsMaSeAF)	Others	Others
D-Mannose isomerase (PsMaSeAF) is a carbohydrate isomerase catalyzing the reversible isomerization of d-mannose to d-fructose. D-Mannose isomerase (PsMaSeAF) belongs to the N-acylglucosamine 2-epimerase (AGE) superfamily along with AGE, cellobiose 2-epimerase (CE), and aldose-ketose isomerase (AKI) .

HY-107404

SID 7969543	Orphan Receptor	Endocrinology
SID 7969543 is a selective SF-1 (steroidogenic factor 1, NR5A1) inhibitor with an IC₅₀ of 760 nM. SID 7969543 inhibits SF-1-triggered luciferase expression with IC₅₀ of 30 nM. SF-1 is a transcription factor belonging to the nuclear receptor superfamily .

HY-P99720

Luspatercept 1 Publications Verification ACE-536; luspatercept–aamt	TGF-beta/Smad	Metabolic Disease Cancer
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .

HY-126666

PNU-159682 carboxylic acid	ADC Cytotoxin	Inflammation/Immunology Cancer
PNU-159682 carboxylic acid (compound 53) is a potent ADCs cytotoxin and encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. PNU-159682 carboxylic acid has protein fold and diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response .

HY-P99157

Omburtamab	CD276/B7-H3	Cancer
Omburtamab is an anti-CD276 (also known as B7-H3) monoclonal antibody, CD276 is a B7/CD28 immunoglobulin superfamily member expressed among solid human tumours. Omburtamab can bind tumor tissues and be used in various cancers research .

HY-P2812

Phospholipase D, Streptomyces chromofuscus PLD	Phospholipase	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Phospholipase D, Streptomyces chromofuscus (PLD) is an enzyme of the phospholipase superfamily, which widely exists in bacteria, yeast, plants, animals and viruses, and is often used in biochemical research. Phospholipase D can catalyze the hydrolysis of phosphodiester bonds in glycerophospholipids to produce phosphatidic acid and soluble choline. Phospholipase D is involved in a variety of disease-related processes, including diabetes, atherogenesis, obesity, tumorigenesis, immune response, and neuroendocrine function .

HY-P2812B

Phospholipase D, cabbage	Phospholipase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Phospholipase D, cabbage is an enzyme of the phospholipase superfamily. Phospholipase D, cabbage is widely found in bacteria, yeast, plants, animals and viruses and is often used in biochemical research. Phospholipase D, cabbage can catalyze the hydrolysis of the phosphodiester bond of glycerophospholipids to produce phosphatidic acid and soluble choline. Phospholipase D, cabbage is involved in a variety of disease-related processes, including diabetes, atherosclerosis, obesity, tumorigenesis, immune response and neuroendocrine function .

HY-120432

CaMdr1p-IN-1	Others	Infection
CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM .

HY-143862

Pparδ agonist 7	PPAR	Metabolic Disease
Pparδ agonist 7 is a potent agonist of Pparδ. The peroxisome proliferator-activated receptor (PPAR) is a member of the intranuclear receptor transcription factor superfamily that plays a key role in the regulation of metabolic homeostasis, inflammation, cell growth and differentiation in vivo. Pparδ agonist 7 has the potential for the research of non-alcoholic fatty liver disease (NAFLD) (extracted from patent WO2019105234A1, compound TM4) .

HY-143863

PPARδ agonist 8	PPAR	Metabolic Disease
Pparδ agonist 8 is a potent agonist of Pparδ. The peroxisome proliferator-activated receptor (PPAR) is a member of the intranuclear receptor transcription factor superfamily that plays a key role in the regulation of metabolic homeostasis, inflammation, cell growth and differentiation in vivo. Pparδ agonist 8 has the potential for the research of non-alcoholic fatty liver disease (NAFLD) (extracted from patent WO2021169769A1, compound TM2) .

HY-P10053

sPLA2-IIA Inhibitor	Phospholipase	Metabolic Disease
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .

HY-P99178

CTX-471	Interleukin Related	Inflammation/Immunology Cancer
CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K_d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer .

Cat. No.	Product Name

HY-L018

TGF-beta/Smad Compound Library	274 compounds
The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc. MCE designs a unique collection of 274 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

TGF-beta/Smad Compound Library

274 compounds

The transforming growth factor beta (TGF-β) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. The TGF-β superfamily comprises TGF-βs, bone morphogenetic proteins (BMPs), activins and related proteins. Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD (e.g. SMAD4). R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. Deregulation of TGF-β signaling contributes to developmental defects and human diseases, including cancers, some bone diseases, chronic kidney disease, etc.

MCE designs a unique collection of 274 TGF-beta/Smad signaling pathway compounds. TGF-beta/Smad Compound Library acts as a useful tool for TGF-beta/Smad-related drug screening and disease research.

HY-L008

JAK/STAT Compound Library	510 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 510 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

510 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 510 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

HY-L081

Phosphatase Inhibitor Library	136 compounds
Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc. Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action. MCE supplies a unique collection of 136 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

Phosphatase Inhibitor Library

136 compounds

Protein phosphorylation is a key post-translational modification underlying the regulation of many cellular processes. Phosphatases and kinases contribute to the regulation of protein phosphorylation homeostasis in the cell. This reversible regulation of protein phosphorylation is critical for the proper control of a wide range of cellular activities, including cell cycle, proliferation and differentiation, metabolism, cell-cell interactions, etc.

Protein phosphatases have evolved in separate families that are structurally and mechanistically distinct. Based on substrate specificity and functional diversity, protein phosphatases are classified into two superfamilies: Protein serine/threonine phosphatases and Protein tyrosine phosphatases. Ser/Thr phosphatases are metalloenzymes belonging to two major gene families termed PPP (phosphoprotein phosphatase) and PPM (metal-dependent protein phosphatases), whereas protein tyrosine phosphatases (PTPs) belong to distinct classes of enzymes that utilize a phospho-cysteine enzyme intermediate as a part of their catalytic action.

MCE supplies a unique collection of 136 phosphatase inhibitors that mainly targeting protein tyrosine phosphatases (PTPs) and serine/threonine-specific protein phosphatases. MCE Phosphatase Inhibitor Library is a useful tool for phosphatase drug discovery and related research.

HY-L038

Differentiation Inducing Compound Library	1,659 compounds
Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method. MCE Differentiation Inducing Compound Library contains a unique collection of 1,659 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

Differentiation Inducing Compound Library

1,659 compounds

Stem cells, which are found in all multi-cellular organisms, can divide and differentiate into diverse special cell types and can self-renew to produce more stem cells. To be useful in therapy, stem cells must be converted into desired cell types as necessary which is called induced differentiation or directed differentiation. Understanding and using signaling pathways for differentiation is an important method in successful regenerative medicine. Small molecules or growth factors induce the conversion of stem cells into appropriate progenitor cells, which will later give rise to the desired cell type. There is a variety of signal molecules and molecular families that may affect the establishment of germ layers in vivo, such as fibroblast growth factors (FGFs); the wnt family or superfamily of transforming growth factors β (TGFβ) and bone morphogenetic proteins (BMP). Unfortunately, for now, a high cost of recombinant factors is likely to limit their use on a larger scale in medicine. The more promising technique focuses on the use of small molecules. These small molecules can be used for either activating or deactivating specific signaling pathways. They enhance reprogramming efficiency by creating cells that are compatible with the desired type of tissue. It is a cheaper and non-immunogenic method.

MCE Differentiation Inducing Compound Library contains a unique collection of 1,659 compounds that act on signaling pathways for differentiation. These compounds are potential stimulators for induced differentiation. This library is a useful tool for researching directed differentiation and regenerative medicine.

7-Ethoxy-4-trifluoromethylcoumarin	Fluorescent Dyes/Probes
7-Ethoxy-4-trifluoromethylcoumarin is a fluorescent substrate of various enzymes of the cytochrome P450 superfamily

Cat. No.	Product Name	Target	Research Area

HY-P3919

Adrenotensin (human) Pro-ADM-153-185 (human)	CGRP Receptor	Cardiovascular Disease
Adrenotensin (human) (Pro-ADM-153-185 (human)) is a 153-185 fragment of precursor peptide of Adrenomedullin. Adrenomedullin (ADM) is a 52-amino acid multifunctional peptide, which belongs to the CGRP superfamily of vasoactive peptide hormones .

HY-P10053

sPLA2-IIA Inhibitor	Phospholipase	Metabolic Disease
sPLA2-IIA Inhibitor is a cyclic pentapeptide analog of FLSYK (cyclic 2-Nal-Leu-Ser-2-Nal-Arg (c2)), that binds to hGIIA (human IIA phospholipase A2) and inhibits its hydrolytic ability. sPLA2 is a member of the esterase superfamily that catalyzes the hydrolysis of the ester bond at the sn-2 position of glycerophospholipids, releasing free fatty acids such as arachidonic acid and lysophospholipids .

Cat. No.	Product Name	Target	Research Area

HY-P99393

Tavolixizumab MEDI 0562; Tavolimab	TNF Receptor	Cancer
Tavolixizumab (MEDI 0562; Tavolimab) is a human monoclonal antibody to TNFRSF4 (TNF receptor superfamily member 4) for use in cancer immunology research .

HY-P99945

Revdofilimab ABBV-368	Orexin Receptor (OX Receptor)	Inflammation/Immunology Cancer
Revdofilimab (ABBV-368) is a human IgG1 agonist monoclonal antibody against OX40. Among them, OX40 is a member of the TNF receptor superfamily expressed on activated and memory T cell subsets and T regulatory cells .

HY-P990070

Zigakibart BION-1301	TNF Receptor	Inflammation/Immunology Cancer
Zigakibart (BION-1301) is an IgG4-kappa, anti-TNFSF13 (tumor necrosis factor (TNF) superfamily member 13, APRIL, CD256) humanized monoclonal antibody. Zigakibart shows anti-inflammatory activity .

HY-P99720

Luspatercept 1 Publications Verification ACE-536; luspatercept–aamt	TGF-beta/Smad	Metabolic Disease Cancer
Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .

HY-P99157

Omburtamab	CD276/B7-H3	Cancer
Omburtamab is an anti-CD276 (also known as B7-H3) monoclonal antibody, CD276 is a B7/CD28 immunoglobulin superfamily member expressed among solid human tumours. Omburtamab can bind tumor tissues and be used in various cancers research .

HY-P990680

Anti-Mouse CD40 Antibody (FGK4.5/FGK45)	Inhibitory Antibodies	Inflammation/Immunology
Anti-Mouse CD40 Antibody (FGK4.5/FGK45) is a rat-derived IgG2a monoclonal antibody targeting mouse CD40. CD40 is a type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 can act as a co-stimulatory molecule to activate B cells, dendritic cells, monocytes, and other APCs, promoting anti-tumor T cell responses.

HY-P99178

CTX-471	Interleukin Related	Inflammation/Immunology Cancer
CTX-471 is a fully human monoclonal antibody of CD137. CTX-471 has bind affinity for recombinant human, cynomolgus macaque CD137 and mouse CD137 with K_d values of 50 nM, 61 nM and 748 nM, respectively. CTX-471 can be used for the research of immunomodulation and cancer .

HY-P990720

Elritercept KER-050	TGF-beta/Smad	Inflammation/Immunology
Elritercept (KER-050) is a recombinant fusion protein comprising a modified activin receptor type IIA extracellular domain fused to a human IgG1 Fc. Elritercept inhibits activin A and other select TGF-β superfamily ligands .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80914

	TNF alpha Antibody TNF; TNFA; TNFSF2; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand Superfamily member 2; TNF-a	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	TNF alpha Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 26 kDa, targeting to TNF alpha. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P81756

	BCMA Antibody (YA1501) TNFRSF17; BCM; BCMA; Tumor necrosis factor receptor Superfamily member 17; B-cell maturation protein; CD269	FC, ELISA	Human
	BCMA Antibody (YA1501) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1501), targeting BCMA. BCMA Antibody (YA1501) can be used for FC, ELISA experiment in human background.

HY-P82571

	4 1BBL Antibody (YA2316) TNFSF9; Tumor necrosis factor ligand Superfamily member 9; 4-1BB ligand; 4-1BBL	WB, IP	Human
	4 1BBL Antibody (YA2316) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2316), targeting 4 1BBL, with a predicted molecular weight of 27 kDa (observed band size: 25-32 kDa). 4 1BBL Antibody (YA2316) can be used for WB, IP experiment in human background.

HY-P81584

	4-1BB Ligand Antibody (YA1329) TNFSF9; Tumor necrosis factor ligand Superfamily member 9; 4-1BB ligand; 4-1BBL	FC, ELISA	Human
	4-1BB Ligand Antibody (YA1329) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1329), targeting 4-1BB Ligand. 4-1BB Ligand Antibody (YA1329) can be used for FC, ELISA experiment in human background.

HY-P81123

	OPG Antibody MGC29565 antibody; OCIF antibody; OPG antibody; Osteoclastogenesis inhibitory factor antibody; Osteoprotegerin antibody; PDB5 antibody; TNF receptor Superfamily member 11b antibody; TNFRSF 11B antibody; TNFRSF11B antibody; TR 1 antibody; TR1 antibody; TR11B_HUMAN antibody; Tumor necrosis factor receptor Superfamily member 11B antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	OPG Antibody is an unconjugated, approximately 46 kDa,mouse-derived, anti-OPG monoclonal antibody. OPG Antibody can be used for: WB, IF-Cell, IHC-P expriments in human, mouse, rat background without labeling.

HY-P83589

	Lymphotoxin alpha Antibody (YA3334) LTalpha; DIF; LT alpha; Lta; Lymphotoxin alpha; TNF B; TNF Superfamily member 1; TNF-beta; TNFB; TNFbeta; TNFSF1; TNLG1E	WB	Human
	Lymphotoxin alpha Antibody (YA3334) is a biotin-conjugated non-conjugated IgG antibody, targeting Lymphotoxin alpha, with a predicted molecular weight of 22 kDa (observed band size: 18 kDa). Lymphotoxin alpha Antibody (YA3334) can be used for WB experiment in human background.

HY-P81762

	TNFSF12 Antibody (YA1507) TNFSF12; APO3L; DR3LG; Tumor necrosis factor ligand Superfamily member 12; APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK	FC, ELISA	Human
	TNFSF12 Antibody (YA1507) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1507), targeting TNFSF12. TNFSF12 Antibody (YA1507) can be used for FC, ELISA experiment in human background.

HY-P83029

	p75 NGF Receptor Antibody (YA2774) CD271 antibody; CD271 antigen antibody; Gp80 LNGFR antibody; Gp80-LNGFR antibody; Low affinity nerve growth factor receptor antibody; Low affinity neurotrophin receptor p75NTR antibody; Low-affinity nerve growth factor receptor antibody; Nerve growth factor receptor antibody; Nerve growth factor receptor TNFR Superfamily member 16 antibody; NGF receptor antibody; Ngfr antibody; p75 ICD antibody; p75 Neurotrophin receptor antibody; p75 NTR antibody; p75(NTR) antibody; p75NTR antibody; TNFR Superfamily Member 16 antibody; TNFRSF16 antibody; TNR16_HUMAN antibody; Tumor necrosis factor receptor Superfamily member 16 antibody	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	NGFR Antibody (YA2774) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2774), targeting NGFR, with a predicted molecular weight of 45 kDa (observed band size: 75 kDa). NGFR Antibody (YA2774) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82712

	ALK-1 Antibody (YA2457) ACVRL1; ACVRLK1; ALK1; Serine/threonine-protein kinase receptor R3; SKR3; Activin receptor-like kinase 1; ALK-1; TGF-B Superfamily receptor type I; TSR-I	WB	Human, Mouse, Rat
	ALK-1 Antibody (YA2457) is a biotin-conjugated non-conjugated IgG antibody, targeting ALK-1, with a predicted molecular weight of 56 kDa (observed band size: 56 kDa). ALK-1 Antibody (YA2457) can be used for WB experiment in human, mouse, rat background.

HY-P81759

	OX40 Antibody (YA1504) TNFRSF4; TXGP1L; Tumor necrosis factor receptor Superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD antigen CD134	FC, ELISA	Human
	OX40 Antibody (YA1504) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1504), targeting OX40. OX40 Antibody (YA1504) can be used for FC, ELISA experiment in human background.

HY-P81730

	OX40L Antibody (YA1475) TNFSF4; TXGP1; Tumor necrosis factor ligand Superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD antigen CD252	FC, ELISA	Human
	OX40L Antibody (YA1475) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1475), targeting OX40L. OX40L Antibody (YA1475) can be used for FC, ELISA experiment in human background.

HY-P81500

	p75 NGF Receptor Antibody (YA1245) NGFR; TNFRSF16; Tumor necrosis factor receptor Superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271	IHC-P	Human
	p75 NGF Receptor Antibody (YA1245) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1245), targeting p75 NGF Receptor. p75 NGF Receptor Antibody (YA1245) can be used for IHC-P experiment in human background.

HY-P81124

	RANKL/CD254 Antibody OPGL; CD254; hRANKL2; ODF; OPGL; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; Receptor activator of nuclear factor kappa B ligand; sOdf; SOFA; TNF related activation induced cytokine; TNFSF 11; TNFSF11; TRANCE; Tumor necrosis factor ligand Superfamily member 11; Osteoprotegerin Ligand; TNF11_HUMAN.	WB, IHC-P, ELISA	Human, Mouse, Rat
	RANKL/CD254 Antibody is an unconjugated, approximately 35 kDa, rabbit-derived, anti-RANKL/CD254 polyclonal antibody. RANKL/CD254 Antibody can be used for: WB, IHC-P, ELISA expriments in human, mouse, rat background without labeling.

HY-P81429

	CLEC4C Antibody (YA1174) CLEC4C; BDCA2, CLECSF11, CLECSF7, DLEC, HECL; UNQ9361/PRO34150; C-type lectin domain family 4 member C; CD303; Blood dendritic cell antigen 2 (BDCA-2); C-type lectin Superfamily member 7; Dendritic lectin	IHC-P	Human
	CLEC4C Antibody (YA1174) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1174), targeting CLEC4C. CLEC4C Antibody (YA1174) can be used for IHC-P experiment in human background.

HY-P81765

	BAFF Antibody (YA1510) TNFSF13B; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; Tumor necrosis factor ligand Superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD257	FC, ELISA	Human
	BAFF Antibody (YA1510) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1510), targeting BAFF. BAFF Antibody (YA1510) can be used for FC, ELISA experiment in human background.

HY-P82843

	DcR2 Antibody (YA2588) TNFRSF10D; DCR2; TRAILR4; TRUNDD; Tumor necrosis factor receptor Superfamily member 10D; Decoy receptor 2; DcR2; TNF-related apoptosis-inducing ligand receptor 4; TRAIL receptor 4; TRAIL-R4; TRAIL receptor with a truncated death domain; CD	WB, IHC-P, ICC/IF	Human
	DcR2 Antibody (YA2588) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2588), targeting DcR2, with a predicted molecular weight of 42 kDa (observed band size: 36 kDa). DcR2 Antibody (YA2588) can be used for WB, IHC-P, ICC/IF experiment in human background.

HY-P81153

	HIF 2 alpha Antibody Basic helix loop helix PAS protein MOP2; Basic-helix-loop-helix-PAS protein MOP2; bHLHe73; Class E basic helix-loop-helix protein 73; ECYT4; Endothelial PAS domain containing protein 1; Endothelial pas domain protein 1; Endothelial PAS domain-containing protein 1; EPAS 1; EPAS-1; EPAS1; EPAS1_HUMAN; HIF 1 alpha like factor; HIF-1-alpha-like factor; HIF-2-alpha; HIF2-alpha; HIF2A; HLF; Hypoxia inducible factor 2 alpha; Hypoxia inducible factor 2 alpha subunit; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; Member of pas Superfamily 2; MOP 2; MOP2; PAS domain-containing protein 2; PASD2.	WB, IHC-P, FC	Human, Mouse, Rat
	HIF 2 alpha Antibody is an unconjugated, approximately 96 kDa, rabbit-derived, anti-HIF 2 alpha monoclonal antibody. HIF 2 alpha Antibody can be used for:WB, IHC-P, FC expriments in human, mouse, rat background without labeling.

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Species:	Human (114) Rhesus Macaque (18) Mouse (59) Rat (26) Cynomolgus (28) Rabbit (4) Canine (5) Pig (1)
Tag:	His (135) SUMO (2) Tag Free (19) Avi (13) Myc (4) Fc (105) Flag (4)
Source:	HEK293 (212) E. coli Cell-free (1) CHO (1) Sf9 insect cells (6) P. pastoris (6) E. coli (28)