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Results for "

alzheimer's disease

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5-HT Receptor (4) AAK1 (1) Acyltransferase (2) Adenosine Receptor (1) Adrenergic Receptor (1) Akt (1) Amino Acid Derivatives (1) Amyloid-β (56) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (2) Apolipoprotein (1) Apoptosis (12) Arginase (1) ATP Citrate Lyase (1) ATP Synthase (1) Autophagy (4) Bacterial (3) Bcr-Abl (1) Beta-lactamase (1) Beta-secretase (15) Biochemical Assay Reagents (2) c-Fms (3) c-Met/HGFR (1) Calcium Channel (1) CaMK (1) Cannabinoid Receptor (2) Carbonic Anhydrase (2) Caspase (3) Cathepsin (2) CCR (1) CDK (2) Cholinesterase (ChE) (103) Collagen (1) COX (1) Cytochrome P450 (1) DAPK (1) DNA/RNA Synthesis (1) Dopamine Transporter (2) Drug Intermediate (1) Drug Isomer (1) DYRK (3) EAAT (1) EGFR (1) Endogenous Metabolite (18) ERK (1) Fluorescent Dye (2) Free Fatty Acid Receptor (1) Fungal (2) Glucocorticoid Receptor (2) GPR55 (2) GPR84 (1) GSK-3 (11) HBV (1) HDAC (7) Histamine Receptor (1) Histone Acetyltransferase (2) Histone Methyltransferase (2) HIV (1) IFNAR (1) IGF-1R (1) iGluR (5) Insulin Receptor (1) Interleukin Related (7) Isotope-Labeled Compounds (13) JNK (4) Keap1-Nrf2 (3) LPL Receptor (2) mAChR (8) MAGL (1) MAP3K (2) MARCKS (2) mGluR (1) MicroRNA (1) Microtubule/Tubulin (2) Mitochondrial Metabolism (3) Molecular Glues (1) Monoamine Oxidase (30) mTOR (2) nAChR (5) Neuropeptide S Receptor (2) NF-κB (4) NO Synthase (2) NOD-like Receptor (NLR) (2) Notch (3) Nuclear Hormone Receptor 4A/NR4A (1) OGA (1) P-glycoprotein (5) P2X Receptor (1) p38 MAPK (1) Phosphatase (2) Phosphodiesterase (PDE) (7) Pim (1) PKC (1) Potassium Channel (1) PPAR (4) Proteasome (1) RAR/RXR (3) Reactive Oxygen Species (6) ROS Kinase (1) Ser/Thr Protease (3) Serotonin Transporter (1) Sigma Receptor (4) Sirtuin (6) Sodium Channel (1) Somatostatin Receptor (1) Tau Protein (14) TGF-β Receptor (3) Thrombopoietin Receptor (3) Thymidylate Synthase (2) TNF Receptor (4) Topoisomerase (1) Transthyretin (TTR) (1) Trk Receptor (2) TRP Channel (2) Tyrosinase (1) Virus Protease (2) Wnt (3) Xanthine Oxidase (2) α-synuclein (3) β-catenin (3) γ-secretase (14)
By Research Areas:	Cancer (46) Cardiovascular Disease (12) Endocrinology (5) Infection (9) Inflammation/Immunology (36) Metabolic Disease (28) Neurological Disease (312)
Click Chemistry:	Alkynes (4)
Oligonucleotides:	Nucleosides and their Analogs (1)

332

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W015229

3-Indolepropionic acid 4 Publications Verification Indole-3-propionic acid; 3-IPA	Endogenous Metabolite Reactive Oxygen Species	Neurological Disease Metabolic Disease
3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.

HY-101710

Benzgalantamine GLN-1062	Drug Intermediate	Neurological Disease
Benzgalantamine (GLN-1062) is a pro-agent of galantamine, used for the treatment for Alzheimer’s disease.

HY-115726

FRM-024	γ-secretase	Neurological Disease
FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease.

HY-P99185

Bapineuzumab	Amyloid-β	Neurological Disease
Bapineuzumab is an anti-β-amyloid protein (APP) monoclonal antibody. Bapineuzumab can be used for the research of Alzheimer’s disease (AD) .

HY-151152

AChE-IN-24	Cholinesterase (ChE)	Neurological Disease
AChE-IN-24 is a potent AChE inhibitor and can penetrate the BBB. AChE-IN-24 has the mighty inhibitory activity to hAChE with an IC₅₀ value of 0.053 μM. AChE-IN-24 can be used for the research of Alzheimer s disease (AD) .

HY-107661A

S-(+)-Arundic Acid (S)ONO-2506; (S)-2-Propyloctanoic acid	Drug Isomer	Others
S-(+)-Arundic Acid ((S)ONO-2506) is the S-enantiomer of Arundic Acid. Arundic acid is an astrocyte-modulating agent, has the potential for stroke and Alzheimer’s disease research .

HY-W839261

Tyrosine kinase-IN-9	Bcr-Abl	Neurological Disease
Tyrosine kinase-IN-9 (Compound B) is the inhibitor for c-Abl. Tyrosine kinase-IN-9 can be used in research of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease .

HY-N13380

6′‐O‐Galloylsalidroside	Others	Cardiovascular Disease Neurological Disease Metabolic Disease
6’-O-Galloylsalidroside is an active component of Rhodiola. 6’-O-Galloylsalidroside is promising for research of Alzheimer’s disease, lung diseases, cerebrovascular disease, diabetes, cardiovascular disease and aging-related diseases .

HY-N8414

Dehydrogeijerin	Cholinesterase (ChE)	Neurological Disease
Dehydrogeijerin is an inhibitor of acetylcholinesterase with an IC₅₀ of 9.7 μM. Dehydrogeijerin can be used in study Alzheimer’s disease .

HY-159173

AChE-IN-71	Cholinesterase (ChE)	Neurological Disease
AChE-IN-71 (compound 12A) is a AChE inhibitor. AChE-IN-71 can be used in the study of Alzheimer’s disease .

HY-P4704

α-Synuclein (61-95) (human)	α-synuclein	Neurological Disease
α-Synuclein (61-95) (human) is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) .

HY-P4704A

α-Synuclein (61-95) (human) TFA	α-synuclein	Neurological Disease
α-Synuclein (61-95) (human) TFA is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) TFA can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) .

HY-168622

AChE-IN-79	Cholinesterase (ChE)	Neurological Disease
AChE-IN-79 (compound 3i) is a AChE inhibitor with the IC₅₀ of 2.7 µM and can be used for study of Alzheimer’s disease .

HY-W020576

Rivastigmine metabolite NAP 226-90	Cholinesterase (ChE)	Neurological Disease
Rivastigmine metabolite (NAP 226-90) is an acetylcholinesterase (AChE) inhibitor which is produced in kidney. Rivastigmine metabolite is promising for research of Alzheimer’s Disease .

HY-163861

Tl45b	Cholinesterase (ChE)	Neurological Disease
Tl45b is an AChE inhibitor, with an IC₅₀ of 0.71 μM. Tl45b can be used for the research of Alzheimer’s disease .

HY-N12075

Dehydrodiscretamine chloride	Cholinesterase (ChE)	Neurological Disease
Dehydrodiscretamine chloride is a dual inhibitor of AChE and BChE with *IC₅₀s of 17.8 and 118.8 μM, respectively. Dehydrodiscretamine chloride has antioxidant activity. Dehydrodiscretamine chloride can be used in study Alzheimer’s disease* .

HY-163349

TUG-2099	GPR84	Cardiovascular Disease Neurological Disease Cancer
TUG-2099 (compound 4s) is a potent GPR84 agonist with the EC₅₀ of 0.3 nM. TUG-2099 can be used for study of Alzheimer’s disease, atherosclerosis, cancer, and so an .

HY-163802

Nurr1 agonist 10	Nuclear Hormone Receptor 4A/NR4A	Neurological Disease
Nurr1 agonist 10 (compound 37) is a potent Nurr1 agonist with an EC₅₀ value of 40 nM. Nurr1 agonist 10 has the potential for the research of Parkinson’s and Alzheimer’s disease .

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Cytochrome P450 P-glycoprotein	Neurological Disease Inflammation/Immunology Cancer
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-115726A

(-)-FRM-024	γ-secretase	Neurological Disease
(-)-FRM-024 is the (-)-isomer of FRM-024, a potent CNS-penetrant gamma secretase modulator that can be utilized in Alzheimer’s disease research .

HY-P1567

β-Amyloid (10-35), amide	Amyloid-β	Neurological Disease
β-Amyloid (10-35), amide is composed of 26 aa (10-35 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease.

HY-144681

Ceperognastat LY3372689	OGA Tau Protein	Neurological Disease
Ceperognastat (LY3372689) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. Ceperognastat can be used for tauopathies research, including Alzheimer’s disease .

HY-119398

Lanuginosine	Amyloid-β Cholinesterase (ChE)	Neurological Disease
Lanuginosine (Compound 12) is an AChE inhibitor (IC₅₀: 10.9 μM). Lanuginosine inhibits Aβ aggregation. Lanuginosine can be used for research of Alzheimer’s disease .

HY-N15450

Undulatine	Cholinesterase (ChE)	Neurological Disease
Undulatine is a potent AChE inhibitor with an IC₅₀ of 7.4 μM. Undulatine is able to cross the BBB by passive permeation and can be used in the study of Alzheimer’s disease .

HY-146137

Transthyretin-IN-1	Transthyretin (TTR)	Neurological Disease
Transthyretin-IN-1 (Compound 1d) is a transthyretin (TTR) fibril formation inhibitor. Transthyretin-IN-1 can be used for Alzheimer’s disease research .

HY-123469

RS-0466	Amyloid-β	Neurological Disease
RS-0466, a neuroprotective compound, inhibits β-amyloid-induced cytotoxicity. RS-0466 can be used for research of Alzheimer’s disease .

HY-130750

Phycocyanobilin	Reactive Oxygen Species	Neurological Disease
Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease .

HY-103479

GOAT-IN-1	Acyltransferase	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of obesity, diabetes, hyperlipidemia, metabolic, non-alcoholic fatty liver, steatohepatitis, sarcopenia, appetite control, alcohol/narcotic dependence, Alzheimer’s disease, Parkinson’s disease, cerebrovascular dementia, cerebral apoplexy, cerebral infarction, cardic disease, some kind of tumors.

HY-170487

MAO-B-IN-38	Monoamine Oxidase	Neurological Disease
MAO-B-IN-38 (Compound 6b) is a reversible and competitive MAO-B inhibitor, with IC₅₀ values of 0.03 and 21.46 µM for MAO-B and MAO-A, respectively. MAO-B-IN-38 can be used for the research of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases .

HY-B1488

Tacrine hydrochloride 5 Publications Verification	Cholinesterase (ChE) iGluR	Neurological Disease
Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with *IC₅₀s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR* inhibitor, with an IC₅₀ of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease .

HY-163175

BChE-IN-24	Cholinesterase (ChE)	Neurological Disease
BChE-IN-24 is a selective and reversible BChE inhibitor with an IC₅₀ of 9 nM. BChE-IN-24 can be used for the research of Alzheimer’s disease and related neurodegenerative disorders .

HY-157089

AChE/MAO-B-IN-5	Monoamine Oxidase Cholinesterase (ChE)	Neurological Disease
AChE/MAO-B-IN-5 is a dual inhibitor of AChE and MAO-B. AChE/MAO-B-IN-5 can used in study Alzheimer’s disease .

HY-14679

GSK3β inhibitor II	GSK-3	Neurological Disease
GSK3β inhibitor II is an inhibitor of GSK3β. GSK3β inhibitor II can be used for research of Alzheimer’s disease (AD) .

HY-P99317

Solanezumab LY-2062430	Amyloid-β	Neurological Disease
Solanezumab is a humanized monoclonal IgG1 antibody directed against the mid-domain of the amyloid-β (Aβ) peptide. Solanezumab has the potential for the research of Alzheimer’s disease .

HY-147060

Dyrk1A-IN-3	DYRK	Neurological Disease
Dyrk1A-IN-3 (Compound 8b), a highly selective dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor, maintains high levels of DYRK1A binding affinity (IC₅₀=76 nM). Dyrk1A-IN-3 can be used for the research of neurodegenerative disorders such as Alzheimer’s Disease, Huntington’s Disease, and Parkinson’s Disease .

HY-N5077

Sinapine 2 Publications Verification	Cholinesterase (ChE) P-glycoprotein	Neurological Disease Inflammation/Immunology Cancer
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-146068

AEP-IN-1	Cathepsin	Neurological Disease
AEP-IN-1 (Compound 13e) is a CNS agent-like non-covalent inhibitor of asparagine endopeptidase (AEP), with the IC₅₀ of 89 nM. AEP-IN-1 can be used for the research of numerous neurological diseases such as Alzheimer’s disease (AD) .

HY-172143

ATUX-8385	Phosphatase	Neurological Disease Cancer
ATUX-8385 is a potent PP2A activator. ATUX-8385 binds to PR65 subunit. ATUX-8385 has the potential for the research of cancers and chronic conditions such as Alzheimer’s disease and chronic obstructive pulmonary disease .

HY-P1389

Neuropeptide S (human)	Neuropeptide S Receptor	Neurological Disease
Neuropeptide S human, a neuropeptide, is a potent cognate neuropeptide S receptor (NPSR) agonist. Neuropeptide S human can be used for Alzheimer's disease (AD) research .

HY-11071

MK-0952 sodium	Phosphodiesterase (PDE)	Neurological Disease
MK-0952 sodium is a selective and orally active PDE4 inhibitor, with an IC₅₀ of 0.53 nM. MK-0952 sodium has the potential for Alzheimer’s disease study .

HY-P2562

β-Amyloid (1-38), mouse, rat	Amyloid-β	Neurological Disease
β-Amyloid (1-38), mouse, rat is composed of 38 aa (1-38 residues of the Aβ peptide) and is the primary component of the amyloid plaques of Alzheimer’s disease .

HY-151370

AChE-IN-26	Cholinesterase (ChE)	Neurological Disease
AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor with an IC₅₀ value of 0.42 μM. AChE-IN-26 can be used for the research of Alzheimer’s disease .

HY-11070

MK-0952	Phosphodiesterase (PDE)	Neurological Disease
MK-0952 is a selective and orally active PDE4 inhibitor, with an IC₅₀ of 0.53 nM. MK-0952 has the potential for Alzheimer’s disease study .

HY-121604

(Rac)-MEM 1003	Calcium Channel	Others
(Rac)-MEM 1003 is the racemate of MEM 1003. MEM 1003, a dihydropyridine compound, is a potent L-type Ca ²⁺ channel antagonist and has the potential for Alzheimer’s disease research .

HY-163885

SSZ	Cholinesterase (ChE) Beta-secretase γ-secretase	Neurological Disease
SSZ is a multi-target inhibitor, which targets multiple pathological mechanisms of Alzheimer's disease (AD). SSZ targets acetylcholinesterase, butyrylcholinesterase, β-site amyloid precursor protein cleavage enzyme 1 (BACE1), and γ-secretase. SSZ ameliorates Alzheimer’s diseases and exhibits neuroprotective effect in mice .

HY-134894A

Glycerophosphorylethanolamine sodium GroPEtn sodium	Amyloid-β	Neurological Disease
Glycerophosphorylethanolamine (GroPEtn) sodium is an active phosphodiester metabolite of Phosphatidylethanolamine (HY-W250118). Glycerophosphorylethanolamine sodium promotes the aggregation of amyloid β-protein (Aβ (1-40)) in vitro. Glycerophosphorylethanolamine sodium can be used in the field of neurodegenerative diseases, such as Alzheimer’s disease research .

HY-162303

C175-0062	Monoamine Oxidase	Neurological Disease
C175-0062 is a monoamine oxidase B (MAO-B) inhibitor. C175-0062 can be used for the research of neurodegenerative disorders, including Parkinson's disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS) .

HY-157400

hMAO-B-IN-7	Monoamine Oxidase	Neurological Disease
hMAO-B-IN-7 (compound 11n) is a potent and blood–brain barrier (BBB) penetrable inhibitor of human monoamine oxidase-B (hMAO-B), with the IC₅₀ value of 0.79±0.05 μM. hMAO-B-IN-7 can be used for Alzheimer’s disease (AD) and Parkinson’s disease (PD) research .

HY-163806

NT376	HDAC	Neurological Disease Cancer
NT376 is a high potency and selectivity inhibitor of class-IIa Histone deacetylases (HDAC) with an IC₅₀ value of 32 nM, similar to NT160 (HY-149285) (IC₅₀= 46 nM) in HT-29 cells. NT376 is proming for research of various cancers and in the diseases of the central nervous system (CNS) such as Alzheimer’s and Huntington’s diseases .

HY-B0107A

Acitretin sodium Ro 10-1670 sodium	RAR/RXR Autophagy	Inflammation/Immunology Cancer
Acitretin (Ro 10-1670) sodium is a second-generation, systemic retinoid that has been used in the treatment of psoriasis. Acitretin sodium also can be used for the research of Alzheimer’s disease .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015229

3-Indolepropionic acid 4 Publications Verification Indole-3-propionic acid; 3-IPA	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Reactive Oxygen Species
3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants Piper nigrum Linn.	Cytochrome P450 P-glycoprotein
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-119398

Lanuginosine	Structural Classification Alkaloids Fissistigma polyanthum (Hook. f. et Thoms.) Merr. Source classification Plants Annonaceae Isoquinoline Alkaloids	Amyloid-β Cholinesterase (ChE)
Lanuginosine (Compound 12) is an AChE inhibitor (IC₅₀: 10.9 μM). Lanuginosine inhibits Aβ aggregation. Lanuginosine can be used for research of Alzheimer’s disease .

HY-130750

Phycocyanobilin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Reactive Oxygen Species
Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease .

HY-N5077

Sinapine 2 Publications Verification	Alkaloids Structural Classification Monophenols Neurological Disease Classification of Application Fields Other Alkaloids Cruciferae Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Cholinesterase (ChE) P-glycoprotein
Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-N0450

Sinapine thiocyanate 2 Publications Verification	Alkaloids Structural Classification Monophenols Classification of Application Fields Other Alkaloids Cruciferae Source classification Phenols Plants Disease Research Fields Cancer	P-glycoprotein Cholinesterase (ChE)
Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-N13380

6′‐O‐Galloylsalidroside	Structural Classification Distylium racemosum Siebold & Zucc. Source classification Phenols Polyphenols Hamamelidaceae Plants	Others
6’-O-Galloylsalidroside is an active component of Rhodiola. 6’-O-Galloylsalidroside is promising for research of Alzheimer’s disease, lung diseases, cerebrovascular disease, diabetes, cardiovascular disease and aging-related diseases .

HY-N8414

Dehydrogeijerin	Structural Classification Natural Products Euryops arabicus Steud. ex Jaub. & Spach Source classification Plants Umbelliferae	Cholinesterase (ChE)
Dehydrogeijerin is an inhibitor of acetylcholinesterase with an IC₅₀ of 9.7 μM. Dehydrogeijerin can be used in study Alzheimer’s disease .

HY-N12075

Dehydrodiscretamine chloride	Structural Classification Alkaloids Piperidine Alkaloids Nandina domestica Thunb. Fissistigma polyanthum (Hook. f. et Thoms.) Merr. Source classification Plants Annonaceae Berberidaceae	Cholinesterase (ChE)
Dehydrodiscretamine chloride is a dual inhibitor of AChE and BChE with *IC₅₀s of 17.8 and 118.8 μM, respectively. Dehydrodiscretamine chloride has antioxidant activity. Dehydrodiscretamine chloride can be used in study Alzheimer’s disease* .

HY-N15450

Undulatine	Structural Classification Alkaloids Crinum moorei Hook. f Other Alkaloids Source classification Plants Amaryllidaceae	Cholinesterase (ChE)
Undulatine is a potent AChE inhibitor with an IC₅₀ of 7.4 μM. Undulatine is able to cross the BBB by passive permeation and can be used in the study of Alzheimer’s disease .

HY-N5077B

Sinapine hydroxide	Alkaloids Monophenols other families Classification of Application Fields Neurological Disease Source classification Phenols Plants Disease Research Fields Inflammation/Immunology	Cholinesterase (ChE) P-glycoprotein
Sinapine hydroxide is an alkaloid isolated from seeds of the cruciferous species. Sinapine hydroxide exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine hydroxide is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-122957

Huperzine C	Lycopodiaceae Alkaloids Lycopodium serratum Thunb． Source classification Plants	Cholinesterase (ChE)
Huperzine C is an alkaloid isolated from Huperzia serrate. Huperzine C is an acetylcholinesterase (AChE) inhibotor, with an IC₅₀ of 0.6 μM. Huperzine C can be used for the research of Alzheimer’s disease .

HY-N12581

Kuwanon U	Structural Classification Flavonoids Flavonones Source classification Morus alba L. Plants Moraceae	Cholinesterase (ChE)
Kuwanon U is a potent cholinesterase inhibitor with *IC₅₀s of 19.69, 10.11 µM and K_is of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease* (AD) .

HY-N2898

Artanin	Source classification Rutaceae Zanthoxylum nitidum (Roxb.) DC. Coumarins Phenylpropanoids Plants	Cholinesterase (ChE)
Artanin is a coumarin, has biological activities related to Alzheimer’s disease. Artanin exerts function including AChE inhibitory and AChE- and self-induced amyloid beta (Aβ) aggregation inhibitory activities, with *IC₅₀*s of 51 μM, 98 μM, and 124 μM, respectively .

HY-Y0399

L-Norvaline Norvaline	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Amyloid-β TNF Receptor Arginase
L-Norvaline is the inhibitor for arginase, that promotes the production of NO, reduces oxidative stress, improves insulin resistance, and exhibits antioxidant and anti-hyperglycemic effects. L-Norvaline can be used in research of Alzheimer’s disease .

HY-113262

8-Hydroxyguanosine	Alkaloids Structural Classification Other Alkaloids Source classification Disease markers Nervous System Disorder Endogenous metabolite	Endogenous Metabolite Interleukin Related
8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of murine B cells with immunostimulatory activity. 8-Hydroxyguanosine is promising for research of Alzheimer’s disease and Down’s syndrome .

HY-N8453

Macranthoin G Methyl 3,5-dicaffeoyl quinic acid	Structural Classification Caprifoliaceae Lonicera japonica Thunb. Source classification Phenols Polyphenols Plants	p38 MAPK
Macranthoin G is an inhibitor of p38 MAPK. Macranthoin G protects the cytotoxicity induced by Aβ or hydrogen peroxide in neuronal cells by downregulating p38 MAPK. Macranthoin G can used in study Alzheimer’s Disease .

HY-N9861

Kayaflavone	Ranunculus ternatus Thunb. Structural Classification Flavonoids Flavones Ranunculaceae Source classification Plants	Amyloid-β
Kayaflavone is an amentoflavone type biflavonoid. Kayaflavone has an inhibitory activity against amyloid-β42 cytotoxicity in PC-12 cells with an EC₅₀ value of 5.29 μΜ. Kayaflavone is promising for research of Alzheimer’s disease .

HY-N7046

Silybin B Silibinin B	Flavanonols Structural Classification Flavonoids Glycine soya Source classification Phenols Polyphenols Cyamopsis tetragonoloba (L.) Taub. Plants Compositae	Amyloid-β
Silybin B (Silibinin B), a flavonolignan separated from Silybum marianum, has anti-tumor activity. Silybin B is the most potent antifibrillogenic and anti-oligomeric component of silymarin and proposes it as a promising anti Alzheimer’s disease agent candidate .

HY-N0450R

Sinapine (thiocyanate) (Standard)	Alkaloids Structural Classification Monophenols Other Alkaloids Cruciferae Source classification Phenols Plants	P-glycoprotein Cholinesterase (ChE)
Sinapine (thiocyanate) (Standard) is the analytical standard of Sinapine (thiocyanate). This product is intended for research and analytical applications. Sinapine thiocyanate is an alkaloid isolated from seeds of the cruciferous species. Sinapine thiocyanate exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine thiocyanate is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .

HY-B0193

Prazosin 10+ Cited Publications	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Prazosin is an α-adrenergic receptor antagonist. Prazosin can reduce inflammation, relieve anxiety, alleviate panic, prevent memory decline, and modulate the pain-relieving effects of opioids. Prazosin can be used in the study of hypertension and Alzheimer’s disease .

HY-W742564

Acacetin-7-O-β-D-galactopyranoside	Structural Classification Flavonoids Flavones Source classification Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae	Cholinesterase (ChE)
Acacetin-7-O-β-D-galactopyranoside is a flavonoid that can be isolated from flower heads of Chrysanthemum morifolium. Acacetin-7-O-β-D-galactopyranoside inhibits AChE activity and can be used for research of Alzheimer’s disease .

HY-N12027

AChE/BChE-IN-14	Structural Classification Alkaloids Fissistigma polyanthum (Hook. f. et Thoms.) Merr. Source classification Plants Annonaceae Isoquinoline Alkaloids	Cholinesterase (ChE)
AChE/BChE-IN-14 (compound 13) is a benzylisoquinoline alkaloid isolated from the roots of Fissistigma polyanthum. AChE/BChE-IN-14 exhibits AChE and BChE inhibitions with antioxidant activities. AChE/BChE-IN-14 can be used for Alzheimer’s disease research .

HY-N0690

Schisandrin C 4 Publications Verification Schizandrin-C; Wuweizisu-C	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Apoptosis Virus Protease Molecular Glues
Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C is a molecular glue. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases research . Schisandrin C induces cell apoptosis .

HY-N3963

Gomisin M2 (+)-Gomisin M2	Classification of Application Fields Neurological Disease Source classification Lignans Plants Infection Monophenols Phenols Phenylpropanoids Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.	HIV
Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits of Schisandra rubriflora with anti-HIV activity (EC₅₀ of 2.4 μM). Gomisin M2 exhibits anti-cancer and anti-allergic activities and has the potential for Alzheimer’s disease research .

HY-N11641

Methyl ganoderate A acetonide	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Cholinesterase (ChE)
Methyl ganoderate A acetonide, a lanostane triterpene, is a natural product that could be isolated from the fruiting bodies of Ganoderma lucidum. Methyl ganoderate A acetonide is a potent AChE inhibitor with an IC₅₀ value of 18.35 μM. Methyl ganoderate A acetonide can be used in research of Alzheimer’s disease (AD) .

HY-17387

(-)-Huperzine A 5 Publications Verification Huperzine A	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Anti-aging Terpenoids Huperziaceae Sesquiterpenes Pyridine Alkaloids Huperzia serrata Plants Disease Research Fields	Cholinesterase (ChE) Apoptosis iGluR
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-N4005

Isoastilbin	Flavanonols Flavonoids other families Source classification Phenols Polyphenols Plants	Bacterial Tyrosinase
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC₅₀ value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .

HY-B1804

Tricaprilin Trioctanoin; Glyceryl trioctanoate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Tricaprilin (Trioctanoin) is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .

HY-W015229R

3-Indolepropionic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite Reactive Oxygen Species
3-Indolepropionic acid (Standard) is the analytical standard of 3-Indolepropionic acid. This product is intended for research and analytical applications. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease. In Vitro: 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease . 3-Indolepropionic acid is a more potent scavenger of hydroxyl radicals than melatonin. Similar to melatonin but unlike other antioxidants, 3-Indolepropionic acid scavenges radicals without subsequently generating reactive and pro-oxidant intermediate compounds . It is also suggested that indolepropionic acid, a gut microbiota-produced metabolite, is a potential biomarker for the development of type 2 diabetes (T2D) that may mediate its protective effect by preservation of β-cell function .

HY-N10701

AChE/BChE-IN-11	Structural Classification Oleaceae Syringa oblata Lindl. Source classification Plants Saccharides Monosaccharides	Cholinesterase (ChE)
AChE/BChE-IN-11 (compound 1) is a potent is a dual AChE and BChE inhibitor with IC₅₀ values of 70 and 71 μM for AChE and BChE, respectively. AChE/BChE-IN-11 is a natural product that could be isolated from the leaf of artichoke . AChE/BChE-IN-11 can be used in research of Alzheimer’s disease (AD) research .

HY-124344

Avenanthramide C	Structural Classification Simple Phenylpropanols Avena sativa Linn. Gramineae Source classification Phenylpropanoids Plants	Interleukin Related
Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .

HY-123033AR

Nicotinamide riboside chloride (Standard)	Alkaloids Structural Classification Animals Source classification Pyridine Alkaloids	Sirtuin Endogenous Metabolite
Nicotinamide riboside (chloride) (Standard) is the analytical standard of Nicotinamide riboside (chloride). This product is intended for research and analytical applications. Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2].

HY-N0690R

Schisandrin C (Standard)	Structural Classification Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill.	Apoptosis Virus Protease
Schisandrin C (Standard) is the analytical standard of Schisandrin C. This product is intended for research and analytical applications. Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C is a molecular glue. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases research . Schisandrin C induces cell apoptosis .

HY-123033A

Nicotinamide riboside chloride Maximum Cited Publications 15 Publications Verification	Alkaloids Structural Classification Animals Neurological Disease Classification of Application Fields Anti-aging Source classification Pyridine Alkaloids Metabolic Disease Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside Chloride, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033

Nicotinamide riboside	Natural Products Human Gut Microbiota Metabolites Microorganisms Animals Neurological Disease Classification of Application Fields Anti-aging Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-N7046R

Silybin B (Standard)	Flavanonols Structural Classification Flavonoids Glycine soya Source classification Phenols Polyphenols Cyamopsis tetragonoloba (L.) Taub. Plants Compositae	Amyloid-β
Silybin B (Standard) is the analytical standard of Silybin B. This product is intended for research and analytical applications. Silybin B (Silibinin B), a flavonolignan separated from Silybum marianum, has anti-tumor activity. Silybin B is the most potent antifibrillogenic and anti-oligomeric component of silymarin and proposes it as a promising anti Alzheimer’s disease agent candidate .

HY-123033B

Nicotinamide riboside tartrate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside tartrate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside tartrate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside tartrate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-123033C

Nicotinamide riboside malate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Sirtuin Endogenous Metabolite
Nicotinamide riboside malate, an orally active NAD ⁺ precursor, increases NAD ⁺ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities . Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease .

HY-10863

Anandamide 1 Publications Verification AEA	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Cannabinoid Receptor PPAR TRP Channel GPR55 Fungal Tau Protein Endogenous Metabolite
Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .

HY-D0186

2'-Deoxyuridine 1 Publications Verification	Infection Structural Classification Natural Products Immune System Disorder Microorganisms Classification of Application Fields Source classification Disease markers Endogenous metabolite Disease Research Fields	Endogenous Metabolite Thymidylate Synthase
2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) .

HY-N11997

Feralolide	Structural Classification Liliaceae Source classification Coumarins Phenols Polyphenols Aloe vera (L.) Burm. f. Phenylpropanoids Plants	Cholinesterase (ChE)
Feralolide is a dihydroisocoumarin isolated from the methanolic extract of aloe vera resin. Feralolide is also a dual inhibitor of AChE and BuChE, with *IC₅₀s of 55 μg/mL and 52 μg/mL respectively. Feralolide has antioxidant activity and inhibits 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2, 2′-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS). Feralolide could be used in research into cognitive disorders such as Alzheimer's disease*, potentially restoring and enhancing memory .

HY-N0226

Epiberberine	Alkaloids Source classification Ranunculaceae Coptis chinensis Franch. Plants Isoquinoline Alkaloids	Cholinesterase (ChE) Beta-secretase
Epiberberine is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with *IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and can be used for the research of Alzheimer* disease . Epiberberine inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberinecan be used for the research of diabetic disease .

HY-N0226A

Epiberberine chloride 4 Publications Verification	Alkaloids Structural Classification Neurological Disease Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields	Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with *IC₅₀s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO ^- scavenging effect (IC₅₀, 16.83 μM), and may protect against Alzheimer* disease . Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .

HY-D0186R

2'-Deoxyuridine (Standard)	Structural Classification Natural Products Immune System Disorder Microorganisms Source classification Disease markers Endogenous metabolite	Endogenous Metabolite Thymidylate Synthase
2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD) . In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine . Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min . In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain . 2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model .

Cat. No.	Product Name	Chemical Structure

HY-W015229S

3-Indolepropionic acid-d2
3-Indolepropionic acid-d₂ is the deuterium labeled 3-Indolepropionic acid. 3-Indolepropionic acid is shown to be a powerful antioxidant and has potential in the treatment for Alzheimer’s disease.

HY-10863S

Anandamide-d8

Anandamide-d8 is a deuterated labeled Anandamide . Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .

HY-17368S1

(Rac)-Rivastigmine-d6

(Rac)-Rivastigmine-d₆ is a labelled racemic Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2].

HY-W654336

(S)-Rivastigmine-d4

(S)-Rivastigmine-d₄ is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-N7046S

Silybin B-d3
Silybin B-d₃ (Silibinin B-d₃) is deuterium labeled Silybin B. Silybin B (Silibinin B), a flavonolignan separated from Silybum marianum, has anti-tumor activity. Silybin B is the most potent antifibrillogenic and anti-oligomeric component of silymarin and proposes it as a promising anti Alzheimer’s disease agent candidate .

HY-17387S1

(-)-Huperzine A-d4 hydrochloride

(-)-Huperzine A-d₄ hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC₅₀ of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .

HY-B1804S1

Tricaprilin-d50
Tricaprilin-d₅₀ (Trioctanoin-d_{50Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .}

HY-117259S

Valiltramiprosate-d6

Valiltramiprosate-d₆ (ALZ-801-d₆) is deuterium labeled Valiltramiprosate. ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound . ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease .

HY-B1804S2

Tricaprilin-d15
Tricaprilin-d₁₅ (Trioctanoin-d_{15Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .}

HY-B1804S

Tricaprilin-13C3

Tricaprilin- ¹³C₃ (Trioctanoin- ¹³C₃) is a ¹³C-labeled Tricaprilin (HY-B1804) . Tricaprilin is an orally active and well tolerated ketogenic agent that safely induces ketosis. Tricaprilin restores brain electrical activity and metabolism to help counteract neuroinflammation in migraine. Tricaprilin is promising for research of migraine prevention and Alzheimer’s disease (AD). Tricaprilin is a pure C8 medium chain triglyceride (MCT) .

HY-W699983

Imidazole-15N2

Imidazole- ¹⁵N₂ (Glyoxaline- ¹⁵N₂) is ¹⁵N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

HY-17368S2

Rivastigmine-d3 hydrochloride

Rivastigmine-d₃ hydrochloride is deuterated labeled Rivastigmine (HY-17368). Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

HY-W654335

Rivastigmine-d4 tartrate

Rivastigmine-d₄ (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC₅₀s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease .

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