Topoisomerase

Topoisomerase Isoform Specific Products:

Topoisomerase Related Products (579)
Antibodies (4)
Topoisomerase Isoform Comparison

By Effects:	Controls (3) Inhibitors (553) Agonists (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-101647A

Intoplicine dimesylate	Inhibitor	98.28%
Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (K_A = 2 x 10⁵ /M) and thereby increases the length of linear DNA.

HY-10919

C-1311	Inhibitor
C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe.

HY-115991

Topoisomerase IV inhibitor 2	Inhibitor
Topoisomerase IV inhibitor 2 (compound 5d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC₅₀s of 0.35 μM and 0.55 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 1.985 μM and 0.744 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively.

HY-158230

SN-398	Inhibitor
SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC₅₀=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells.

HY-146163

Topoisomerase II inhibitor 7	Inhibitor
Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC₅₀ of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis.

HY-13551B

Amsacrine (gluconate)	Inhibitor
Amsacrine gluconate is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.

HY-146497

Topoisomerase I inhibitor 7	Inhibitor
Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones.

HY-159483

SelB-1	Inhibitor
SelB-1 serves as a dual inhibitor for Topoisomerase I/II. SelB-1 possesses anticancer activity and can be utilized in the research of prostate cancer and colon cancer. Furthermore, SelB-1 is also capable of inducing autophagy gene expression and lipid peroxidation, while simultaneously reducing the level of GSH.

HY-19943

TLC388	Inhibitor
TLC388 is a novel camptothecin analog with limited antitumor activity in metastatic NEC.

HY-145290

CPT-Se3	Inhibitor
CPT-Se3, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT–Se3 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se3 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC₅₀= 2.19-4.7 μM).

HY-169628

Topoisomerase I/II inhibitor 7	Inhibitor
Topoisomerase I/II inhibitor 7 (Compound 5h) is a Topoisomerase I/II inhibitor.

HY-158138

TOPOI/PARP-1-IN-1	Inhibitor
TOPOI/PARP-1-IN-1 (Compound B6) is an orally active, low cytotoxic TOPOI/PARP dual inhibitor with an IC₅₀ value of 0.09 μM for PARP1. TOPOI/PARP-1-IN-1 can effectively inhibit the proliferation and migration of cancer cells. TOPOI/PARP-1-IN-1 also causes cell cycle arrest in the G0/G1 phase and induces apoptosis. The tumor growth inhibition rate (TGI) of TOPOI/PARP-1-IN-1 in mice is 75.4%.

HY-W338859

Levofloxacin mesylate	Inhibitor
Levofloxacin mesylate is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin mesylate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin mesylate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin mesylate shows anti-orthopoxvirus activity.

HY-152479

Topoisomerase IIα-IN-7	Inhibitor
Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC₅₀ value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability.

HY-18351A

Indotecan hydrochloride	Inhibitor
Indotecan hydrochloride, an indenoisoquinoline derivative, is a potent Topoisomerase I inhibitor, with IC₅₀s of 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively. Indotecan hydrochloride prevents the relaxation of supercoiled DNA and can be used for the research of visceral leishmaniasis.

HY-18258S

Berberine-d₆ chloride	Inhibitor
Berberine-d₆ (chloride) is the deuterium labeled Berberine chloride. Berberine chloride is an alkaloid that acts as an antibiotic. Berberine chloride induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties[1].

HY-114983

Chimmitecan	Inhibitor	98.96%
Chimmitecan ((S)-9-Allyl-10-Hydroxycamptothecin), a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560), is a potent inhibitor of topoisomerase I. Chimmitecan exhibits anticancer activity.

HY-N6621A

Hippeastrine hydrobromide	Inhibitor
Hippeastrine hydrobromide is an active alkaloid that exhibits a good dose-dependent inhibitory effect on topoisomerase I (Top I) with an IC₅₀ of 7.25?μg/mL. Hippeastrine hydrobromide exhibits antiproliferative and anticancer activities.

HY-N6054

Niranthin	Inhibitor
Niranthin, a lignan with a wide spectrum of pharmacological activities. Niranthin is a potent and non-competitive inhibitor of heterodimeric type IB topoisomerase of L. donovani. Niranthin can be used for the research of drug-resistant leishmaniasis research.

HY-B0067B

(R)-Amrubicin	Inhibitor
(R)-Amrubicin ((R)-SM-5887) is an anthracycline that effectively treats lung cancer by intercalating into DNA and inhibiting topoisomerase II activity, which consequently hampers DNA replication as well as RNA and protein synthesis, leading to cell growth inhibition and apoptosis. This compound exhibits superior anti-tumor efficacy compared to traditional anthracycline drugs while lacking the cumulative cardiac toxicity typically associated with this drug class.

Doxorubicin hydrochloride		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM	99.90%
Etoposide			Topoisomerase II	99.94%
Dxd		Topoisomerase I, IC₅₀: 0.31 μM		99.43%
SN-38		Topoisomerase I		99.89%
Topoisomerase II inhibitor 20 TFA			Topoisomerase II, IC₅₀: 0.98 μM
Camptothecin		Topoisomerase I, IC₅₀: 679 nM		99.86%
Irinotecan		Topoisomerase I		99.97%
Topotecan hydrochloride		Topoisomerase I		99.89%
Daunorubicin hydrochloride			Topoisomerase II	99.67%
Mitoxantrone			Topoisomerase II	99.58%
Epirubicin hydrochloride	Topoisomerase			99.16%
Irinotecan hydrochloride		Topoisomerase I		99.89%
Datopotamab deruxtecan		Topoisomerase I		99.54%
Levofloxacin	TOPO IV			99.92%
Idarubicin hydrochloride			Topoisomerase II	99.94%
Betulinic acid		Topoisomerase I, IC₅₀: 5 μM		99.06%
Mitoxantrone dihydrochloride			Topoisomerase II	99.55%
β-Lapachone		Topoisomerase I		99.96%
Dxd-d₅		Topoisomerase I, IC₅₀: 0.31 μM		98.84%
Teniposide			Topoisomerase II	99.00%
Pirarubicin			Topoisomerase II	99.61%
Irinotecan hydrochloride trihydrate		Topoisomerase I		99.89%
Belotecan hydrochloride		Top1		99.88%
Etoposide phosphate			Topoisomerase II
PNU-159682		Topoisomerase I		98.25%
Aclacinomycin A		Topoisomerase I	Topoisomerase II	99.30%
Aldoxorubicin			Topoisomerase II
Aurintricarboxylic acid			Topoisomerase II
Banoxantrone dihydrochloride			Topoisomerase II	99.46%
Nalidixic acid	Topoisomerase			99.97%
Proscillaridin A		Topoisomerase I, IC₅₀: 30 nM	Topoisomerase II, IC₅₀: 100 nM	99.74%
Levofloxacin hydrate	TOPO IV			99.93%
Pirarubicin Hydrochloride			Topoisomerase II	99.14%
Pixantrone			Topoisomerase II	98.75%
(S)-10-Hydroxycamptothecin		Topoisomerase I		99.38%
Ellipticine			Topoisomerase II	99.56%
Bisantrene			Topoisomerase II	98.08%
Amsacrine			Topoisomerase II	99.95%
Gatifloxacin			Topoisomerase II, IC₅₀: 36.7 μM	99.69%
MC-GGFG-AM-(10Me-11F-Camptothecin)		Topoisomerase I		98.06%
Ellipticine hydrochloride			Topoisomerase II	99.34%
PluriSIn #2			topoisomerase II alpha	≥98.0%
Hycanthone		Topoisomerase I	Topoisomerase II	99.97%
Amonafide			Topoisomerase II	99.92%
Voreloxin Hydrochloride			Topoisomerase II	99.58%
Coralyne chloride		Topoisomerase I		98.30%
Amsacrine hydrochloride			Topoisomerase II	99.98%
Amrubicin			Topoisomerase II	≥98.0%
9-Aminocamptothecin		Topoisomerase I		98.89%
TAS-103 dihydrochloride		Topoisomerase I	Topoisomerase II	98.87%
Genz-644282		Topoisomerase I		99.53%
MC-DOXHZN hydrochloride			Topoisomerase II	98.04%
Chloroquinoxaline sulfonamide			topoisomerase II alpha topoisomerase II beta	99.06%
Indotecan		Topoisomerase I		≥98.0%
(±)-10-Hydroxycamptothecin		Topoisomerase I		99.57%
Nalidixic acid sodium salt	Topoisomerase			99.83%
Flumequine			Topoisomerase II, IC₅₀: 15 μM
Daun02	Topoisomerase			98.72%
Intoplicine		Topoisomerase I	Topoisomerase II	98.36%
Gimatecan		Topoisomerase I		99.28%
Gatifloxacin hydrochloride			Topoisomerase II, : 36.7 μM	99.94%
Lurtotecan		Topoisomerase I		98.01%
Isodiospyrin		Topoisomerase I		99.77%
(±)-Evodiamine		Top1		99.74%
Karenitecin		Topoisomerase I		98.02%
LMP744 hydrochloride		Top1		99.70%
Levofloxacin hydrochloride	TOPO IV			≥98.0%
Groenlandicine		Topoisomerase I		99.87%
Indimitecan		Top1		98.30%
Namitecan		Topoisomerase I		99.25%
ARN-21934			topoisomerase II alpha topoisomerase II beta	98.08%
Podocarpusflavone A		Topoisomerase I, IC₅₀: 119.425 μM		99.62%
LMP517		Topoisomerase I	Topoisomerase II	99.58%
Garenoxacin Mesylate hydrate	TOPO IV, IC₅₀: 1.5-2.5 μg/mL			99.78%
LMP744		Top1		98.85%
Aclacinomycin A hydrochloride		Topoisomerase I	Topoisomerase II
Topoisomerase I inhibitor 8		Topoisomerase I
Elomotecan hydrochloride		Topoisomerase I	Topoisomerase II
Epirubicin	Topoisomerase			98.45%
Zabofloxacin hydrochloride		Topoisomerase I	Topoisomerase II	99.54%
9-Hydroxyellipticine hydrochloride			Topoisomerase II	≥99.0%
SW044248		Topoisomerase I		99.60%
Topotecan		Topoisomerase I
Doxorubicin		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM
Daunorubicin			Topoisomerase II
Topoisomerase II inhibitor 20			Topoisomerase II, IC₅₀: 0.98 μM	98.44%
Pefloxacin		Topoisomerase I		99.79%
CH-0793076		Topoisomerase I, IC₅₀: 2.3 μM
AQ4			Topoisomerase II
BNS-22			topoisomerase II alpha, IC₅₀: 2.8 μM (in human) topoisomerase II beta, IC₅₀: 0.42 μM (in human)	99%
Seconeolitsine		Topoisomerase I, IC₅₀: 17 μM
Edotecarin		Topoisomerase I, IC₅₀: 50 nM		98.39%
CH-0793076 TFA		Topoisomerase I, IC₅₀: 2.3 μM		98.71%
Zabofloxacin		Topoisomerase I	Topoisomerase II	98.02%
Amrubicin hydrochloride			Topoisomerase II
Pixantrone free base			Topoisomerase II
Voreloxin			Topoisomerase II	99.26%
TAS-103		Topoisomerase I	Topoisomerase II
MC-DOXHZN			Topoisomerase II
Topotecan hydrochloride hydrate		Topoisomerase I
Etoposide phosphate disodium			Topoisomerase II
Idarubicin			Topoisomerase II
Gatifloxacin sesquihydrate			Topoisomerase II, IC₅₀: 36.7 μM
Rebeccamycin		Topoisomerase I
Mitoxantrone diacetate			Topoisomerase II
CBX-12		Topoisomerase I
Daunorubicin citrate			Topoisomerase II
Antitumor agent-63		Top1
Silatecan		Topoisomerase I
Topoisomerase II inhibitor 9			Topoisomerase II, IC₅₀: 0.97 μM
Topo I/COX-2-IN-1		Topoisomerase I, IC₅₀: 4.42 μM
Bimolane			Topoisomerase II
T-2513 hydrochloride		Topoisomerase I
TOPOI/PARP-1-IN-2		Top1, IC₅₀: 46.2 nM
Topo I/COX-2-IN-2		Topoisomerase I, IC₅₀: 0.90 μM
Topoisomerase II inhibitor 11			Topoisomerase II, IC₅₀: 2.89 μM
CS1			topoisomerase II alpha
T-2513		Topoisomerase I
Razoxane			Topoisomerase II	99.16%
Topoisomerase IIα-IN-3			topoisomerase II alpha
Heliquinomycin		Topoisomerase I	Topoisomerase II
Topoisomerase II/EGFR-IN-1			Topoisomerase II
VcMMAE-Deruxtecan		Topoisomerase I
Anticancer agent 75			Topoisomerase II
CP-67804			Topoisomerase II
DTS-108		Top1
Pixantrone hydrochloride			Topoisomerase II
Topoisomerase II inhibitor 4			Topoisomerase II
Topoisomerase IIα-IN-6			topoisomerase II alpha, IC₅₀: 0.67 μM
Topoisomerase IIα-IN-2			topoisomerase II alpha topoisomerase II beta
Topoisomerase IIα-IN-4			topoisomerase II alpha, IC₅₀: 3.8 μM topoisomerase II beta, IC₅₀: 10.1 μM
ZLHQ-5f		Top1
3-Fluoro-evodiamine glucose		Topoisomerase I	Topoisomerase II
Topo I-IN-1		Topoisomerase I
Topoisomerase I/II inhibitor 6		Topoisomerase I, IC₅₀: 4.77 μM	Topoisomerase II, IC₅₀: 15 μM
EGFR-IN-116			Topoisomerase II, IC₅₀: 19.74 μM
Top/HDAC-IN-2		Top1	Topoisomerase II
Anti-MRSA agent 7	TOPO IV, IC₅₀: 0.059 μM (E. coli ) TOPO IV, IC₅₀: 0.341 μM (S. aureus)
Topoisomerase II inhibitor 18			Topoisomerase II, IC₅₀: 7.5 μM
Topoisomerase I inhibitor 17		Top1
Elomotecan		Topoisomerase I	Topoisomerase II
Topoisomerase II inhibitor 5			Topoisomerase II
LE01		Topoisomerase I
HSP90-IN-13	Topoisomerase-2, IC₅₀: 25.85 nM
Topoisomerase I inhibitor 2		Topoisomerase I, IC₅₀: 0.58 μM
iNOS/TopoI-IN-1		Topoisomerase I, Ki: 2.72 μM
Topoisomerase II inhibitor 10			Topoisomerase II, IC₅₀: 7.45 μM
Salvicine			Topoisomerase II, IC₅₀: 3 μM
Topoisomerase IV inhibitor 1	TOPO IV, IC₅₀: 0.23 μM
Topoisomerase II inhibitor 13			Topoisomerase II	99.26%
EGFR-IN-57			topoisomerase II beta, IC₅₀: 0.13 μM
Topoisomerase IIα-IN-1			topoisomerase II alpha topoisomerase II beta
Huanglongmycin N		Topoisomerase I, EC₅₀: 14 μM
Topoisomerase IIα-IN-8			topoisomerase II alpha
Tilatamig samrotecan		Topoisomerase I
Deruxtecan-Eribulin		Topoisomerase I
CP-67015			Topoisomerase II
Tapcin		Topoisomerase I, IC₅₀: 203 nM	Topoisomerase II, IC₅₀: 71 nM
Topoisomerase I inhibitor 12		Topoisomerase I
Topoisomerase II inhibitor 17			Topoisomerase II, IC₅₀: 0.23 μM
Topoisomerase I/II inhibitor 2		Topoisomerase I	Topoisomerase II
Topo I/II-IN-2		Topoisomerase I	Topoisomerase II
Saintopin		Topoisomerase I	Topoisomerase II
Intoplicine dimesylate		Topoisomerase I	Topoisomerase II	98.28%
Topoisomerase IV inhibitor 2	TOPO IV, IC₅₀: 0.35 μM
Topoisomerase II inhibitor 7			topoisomerase II alpha, IC₅₀: 3.19 μM
Topoisomerase I/II inhibitor 7		Topoisomerase I	Topoisomerase II
Topoisomerase IIα-IN-7			topoisomerase II alpha, IC₅₀: 7.7 μM
Niranthin	Topoisomerase
Epolactaene			Topoisomerase II, IC₅₀: 10 μM
Topoisomerase I inhibitor 3		Topoisomerase I
Topoisomerase II inhibitor 19			Topoisomerase II, IC₅₀: 0.34 μM
Corydamine		Topoisomerase I	Topoisomerase II
TP0480066			Topoisomerase II
AZD5099			Topoisomerase II
Topoisomerase I inhibitor 16		Topoisomerase I
TP3011		Topoisomerase I
Topoisomerase II inhibitor 8			Topoisomerase II, IC₅₀: 0.52 μM
Topoisomerase I/II inhibitor 3		Topoisomerase I	Topoisomerase II
Gatifloxacin mesylate			Topoisomerase II, IC₅₀: 36.7 μM
Topoisomerase IIα-IN-5			topoisomerase II alpha
Bakuchicin			Topoisomerase II, IC₅₀: 404 μM
Thaspine acetate		Topoisomerase I	Topoisomerase II
Antibacterial agent 229	TOPO IV, IC₅₀: 10.88 μM
(-)-BO 2367			Topoisomerase II
8-Chloro-ATP tetrasodium			Topoisomerase II
Garenoxacin	TOPO IV, IC₅₀: 1.5-2.5 μg/mL
HU 331			Topoisomerase II
Luotonin F			Topoisomerase II
Topovale		Topoisomerase I
NK 314			topoisomerase II alpha
8-Chloro-ATP			Topoisomerase II

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Topoisomerase

Topoisomerase

Topoisomerase Isoform Specific Products:

Topoisomerase Isoform Specific Products:

Topoisomerase Related Products (579)

Antibodies (4)

Topoisomerase Isoform Comparison

Topoisomerase Related Products (579):