Topoisomerase

Topoisomerase Isoform Specific Products:

Topoisomerase Related Products (585)
Antibodies (4)
Topoisomerase Isoform Comparison

By Effects:	Controls (3) Inhibitors (559) Agonists (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-149925

DNA Gyrase-IN-6	Inhibitor
Antibacterial agent 138 is a benzothiazole inhibitor of bacterial DNA gyrase and topoisomerase IV. Antibacterial agent 138 exhibits favorable solubility and plasma protein binding. Antibacterial agent 138 has antibacterial activity against Gram-positive and Gram-negative strains. Antibacterial agent 138 is a dual GyrB and ParE inhibitor.

HY-16562AS

Irinotecan-d₅ hydrochloride	Inhibitor
Irinotecan-d₅ hydrochloride is deuterated labeled Irinotecan hydrochloride (HY-16562A). Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer.

HY-156517

7Ethanol-10NH2-11F-Camptothecin	Inhibitor
7Ethanol-10NH2-11F-Camptothecin is a Camptothecin (HY-16560) analogue that serves as an ADC cytotoxin for the synthesis of antibody-drug conjugates (ADCs). 7Ethanol-10NH2-11F-Camptothecin can inhibit tumor growth and is used in cancer research.

HY-162959

BWC0977	Inhibitor
BWC0977 is a potent bacterial topoisomerase inhibitor that inhibits bacterial DNA replication via inhibition of DNA gyrase and topoisomerase IV. BWC0977 exhibits a minimum inhibitory concentration (MIC90) of 0.03-2 µg/mL against MDR (Multi-Drug Resistant) Gram-negative bacteria.

HY-158391

Anticancer agent 218	Inhibitor
Anticancer agent 218 (P136) is a Camptothecin compound, with anticancer activity.

HY-120185

Saintopin	Inhibitor
Saintopin is an antitumor antibiotic. Saintopin is also an inhibitor of DNA topoisomerases I and II. Saintopin induces DNA cleavage.

HY-101647A

Intoplicine dimesylate	Inhibitor	98.28%
Intoplicine (RP 60475) dimesylate, an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine dimesylate strongly binds DNA (K_A = 2 x 10⁵ /M) and thereby increases the length of linear DNA.

HY-10919

C-1311	Inhibitor
C-1311 shows to inhibit the catalytic activity of DNA topoisomerase II in vitro and in tumour cells. C-1311 prolongs G2 arrest followed by G2 to M transit and cell death during mitosis in the process of mitotic catastrophe.

HY-115991

Topoisomerase IV inhibitor 2	Inhibitor
Topoisomerase IV inhibitor 2 (compound 5d) is a potent DNA topoisomerase IV (TOPO IV) inhibitor with IC₅₀s of 0.35 μM and 0.55 μM for TOPO IV and DNA gyrase, respectively. Topoisomerase IV inhibitor 2 has anti-bacterial activity, with MICs of 1.985 μM and 0.744 μM in Staphylococcus aureus Newman and Escherichia coli ATCC8739, respectively.

HY-158230

SN-398	Inhibitor
SN-398 is a derivative of Camptothecin (HY-158230), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC₅₀=1.562 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells.

HY-146163

Topoisomerase II inhibitor 7	Inhibitor
Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC₅₀ of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis.

HY-13551B

Amsacrine (gluconate)	Inhibitor
Amsacrine gluconate is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.

HY-146497

Topoisomerase I inhibitor 7	Inhibitor
Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lymphoma transplants. Topoisomerase I inhibitor 7 indicates prospects for further search of new antitumor agent candidates among the heteroarene-fused anthraquinones.

HY-159483

SelB-1	Inhibitor
SelB-1 serves as a dual inhibitor for Topoisomerase I/II. SelB-1 possesses anticancer activity and can be utilized in the research of prostate cancer and colon cancer. Furthermore, SelB-1 is also capable of inducing autophagy gene expression and lipid peroxidation, while simultaneously reducing the level of GSH.

HY-19943

TLC388	Inhibitor
TLC388 is a novel camptothecin analog with limited antitumor activity in metastatic NEC.

HY-145290

CPT-Se3	Inhibitor
CPT-Se3, a selenoproagent of Camptothecin (CPT), shows improved potency in killing cancer cells and inhibiting tumor growth. CPT–Se3 decreases the GSH/GSSG ratio and total thiols, elevates the ROS level in Hep G2 cells, and eventually induces apoptosis of cancer cells. CPT-Se3 shows cytotoxicity against HeLa, Hep G2, A549, and SMMC-7721 cells (IC₅₀= 2.19-4.7 μM).

HY-169628

Topoisomerase I/II inhibitor 7	Inhibitor
Topoisomerase I/II inhibitor 7 (Compound 5h) is a Topoisomerase I/II inhibitor.

HY-158138

TOPOI/PARP-1-IN-1	Inhibitor
TOPOI/PARP-1-IN-1 (Compound B6) is an orally active, low cytotoxic TOPOI/PARP dual inhibitor with an IC₅₀ value of 0.09 μM for PARP1. TOPOI/PARP-1-IN-1 can effectively inhibit the proliferation and migration of cancer cells. TOPOI/PARP-1-IN-1 also causes cell cycle arrest in the G0/G1 phase and induces apoptosis. The tumor growth inhibition rate (TGI) of TOPOI/PARP-1-IN-1 in mice is 75.4%.

HY-W338859

Levofloxacin mesylate	Inhibitor
Levofloxacin mesylate is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin mesylate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin mesylate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin mesylate shows anti-orthopoxvirus activity.

HY-152479

Topoisomerase IIα-IN-7	Inhibitor
Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC₅₀ value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability.

Doxorubicin hydrochloride		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM	99.90%
Etoposide			Topoisomerase II	99.94%
Dxd		Topoisomerase I, IC₅₀: 0.31 μM		99.43%
SN-38		Topoisomerase I		99.89%
Topoisomerase II inhibitor 20 TFA			Topoisomerase II, IC₅₀: 0.98 μM
Camptothecin		Topoisomerase I, IC₅₀: 679 nM		99.86%
Irinotecan		Topoisomerase I		99.97%
Topotecan hydrochloride		Topoisomerase I		99.89%
Daunorubicin hydrochloride			Topoisomerase II	99.67%
Mitoxantrone			Topoisomerase II	99.58%
Epirubicin hydrochloride	Topoisomerase			99.16%
Irinotecan hydrochloride		Topoisomerase I		99.89%
Datopotamab deruxtecan		Topoisomerase I		99.54%
Levofloxacin	TOPO IV			99.92%
Idarubicin hydrochloride			Topoisomerase II	99.94%
Betulinic acid		Topoisomerase I, IC₅₀: 5 μM		99.06%
Mitoxantrone dihydrochloride			Topoisomerase II	99.55%
β-Lapachone		Topoisomerase I		99.96%
Teniposide			Topoisomerase II	99.00%
Dxd-d₅		Topoisomerase I, IC₅₀: 0.31 μM		98.84%
Pirarubicin			Topoisomerase II	99.61%
Etoposide phosphate			Topoisomerase II
Irinotecan hydrochloride trihydrate		Topoisomerase I		99.89%
Belotecan hydrochloride		Top1		99.88%
PNU-159682		Topoisomerase I		98.25%
Aldoxorubicin			Topoisomerase II
Aclacinomycin A		Topoisomerase I	Topoisomerase II	99.30%
Aurintricarboxylic acid			Topoisomerase II
Banoxantrone dihydrochloride			Topoisomerase II	99.46%
Nalidixic acid	Topoisomerase			99.97%
Proscillaridin A		Topoisomerase I, IC₅₀: 30 nM	Topoisomerase II, IC₅₀: 100 nM	99.74%
Levofloxacin hydrate	TOPO IV			99.93%
Pirarubicin Hydrochloride			Topoisomerase II	99.14%
Pixantrone			Topoisomerase II	98.75%
(S)-10-Hydroxycamptothecin		Topoisomerase I		99.67%
Ellipticine			Topoisomerase II	99.56%
Bisantrene			Topoisomerase II	98.08%
Gatifloxacin			Topoisomerase II, IC₅₀: 36.7 μM	99.69%
Amsacrine			Topoisomerase II	99.95%
MC-GGFG-AM-(10Me-11F-Camptothecin)		Topoisomerase I		98.06%
Ellipticine hydrochloride			Topoisomerase II	99.34%
PluriSIn #2			topoisomerase II alpha	≥98.0%
Hycanthone		Topoisomerase I	Topoisomerase II	99.97%
Coralyne chloride		Topoisomerase I		98.30%
Amonafide			Topoisomerase II	99.92%
Voreloxin Hydrochloride			Topoisomerase II	99.58%
Amsacrine hydrochloride			Topoisomerase II	99.98%
Amrubicin			Topoisomerase II	≥98.0%
Genz-644282		Topoisomerase I		99.53%
9-Aminocamptothecin		Topoisomerase I		98.89%
TAS-103 dihydrochloride		Topoisomerase I	Topoisomerase II	98.87%
Indotecan		Topoisomerase I		≥98.0%
MC-DOXHZN hydrochloride			Topoisomerase II	98.04%
Chloroquinoxaline sulfonamide			topoisomerase II alpha topoisomerase II beta	99.06%
Flumequine			Topoisomerase II, IC₅₀: 15 μM	99.89%
(±)-10-Hydroxycamptothecin		Topoisomerase I		99.57%
Daun02	Topoisomerase			98.72%
Nalidixic acid sodium salt	Topoisomerase			99.83%
Intoplicine		Topoisomerase I	Topoisomerase II	98.36%
Gimatecan		Topoisomerase I		99.28%
Gatifloxacin hydrochloride			Topoisomerase II, : 36.7 μM	99.94%
LMP744 hydrochloride		Top1		99.70%
Lurtotecan		Topoisomerase I		98.01%
Isodiospyrin		Topoisomerase I		99.77%
(±)-Evodiamine		Top1		99.74%
Karenitecin		Topoisomerase I		98.02%
Levofloxacin hydrochloride	TOPO IV			≥98.0%
Groenlandicine		Topoisomerase I		99.87%
Indimitecan		Top1		98.30%
LMP744		Top1		98.85%
Namitecan		Topoisomerase I		99.25%
ARN-21934			topoisomerase II alpha topoisomerase II beta	98.08%
Podocarpusflavone A		Topoisomerase I, IC₅₀: 119.425 μM		99.62%
LMP517		Topoisomerase I	Topoisomerase II	99.58%
Garenoxacin Mesylate hydrate	TOPO IV, IC₅₀: 1.5-2.5 μg/mL			99.78%
Aclacinomycin A hydrochloride		Topoisomerase I	Topoisomerase II
Topoisomerase I inhibitor 8		Topoisomerase I		99.87%
Elomotecan hydrochloride		Topoisomerase I	Topoisomerase II
Seconeolitsine		Topoisomerase I, IC₅₀: 17 μM
Epirubicin	Topoisomerase			98.45%
Zabofloxacin hydrochloride		Topoisomerase I	Topoisomerase II	99.54%
9-Hydroxyellipticine hydrochloride			Topoisomerase II	≥99.0%
SW044248		Topoisomerase I		99.60%
Voreloxin			Topoisomerase II	99.26%
Topotecan		Topoisomerase I
Doxorubicin		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM
Daunorubicin			Topoisomerase II
Topoisomerase II inhibitor 20			Topoisomerase II, IC₅₀: 0.98 μM	98.44%
Pefloxacin		Topoisomerase I		99.79%
CH-0793076		Topoisomerase I, IC₅₀: 2.3 μM
VcMMAE-Deruxtecan		Topoisomerase I
AQ4			Topoisomerase II
BNS-22			topoisomerase II alpha, IC₅₀: 2.8 μM (in human) topoisomerase II beta, IC₅₀: 0.42 μM (in human)	99%
Edotecarin		Topoisomerase I, IC₅₀: 50 nM		98.39%
CH-0793076 TFA		Topoisomerase I, IC₅₀: 2.3 μM		98.71%
Zabofloxacin		Topoisomerase I	Topoisomerase II	98.02%
Amrubicin hydrochloride			Topoisomerase II
Pixantrone free base			Topoisomerase II
TAS-103		Topoisomerase I	Topoisomerase II
MC-DOXHZN			Topoisomerase II
Topotecan hydrochloride hydrate		Topoisomerase I
Etoposide phosphate disodium			Topoisomerase II
Idarubicin			Topoisomerase II
Gatifloxacin sesquihydrate			Topoisomerase II, IC₅₀: 36.7 μM
Rebeccamycin		Topoisomerase I
Mitoxantrone diacetate			Topoisomerase II
CBX-12		Topoisomerase I
Daunorubicin citrate			Topoisomerase II
Antitumor agent-63		Top1
Silatecan		Topoisomerase I
Topoisomerase II inhibitor 9			Topoisomerase II, IC₅₀: 0.97 μM
Topo I/COX-2-IN-1		Topoisomerase I, IC₅₀: 4.42 μM
Bimolane			Topoisomerase II
T-2513 hydrochloride		Topoisomerase I
TOPOI/PARP-1-IN-2		Top1, IC₅₀: 46.2 nM
Topo I/COX-2-IN-2		Topoisomerase I, IC₅₀: 0.90 μM
Topoisomerase II inhibitor 11			Topoisomerase II, IC₅₀: 2.89 μM
CS1			topoisomerase II alpha
T-2513		Topoisomerase I
Razoxane			Topoisomerase II	99.16%
Topoisomerase IIα-IN-3			topoisomerase II alpha
Heliquinomycin		Topoisomerase I	Topoisomerase II
Topoisomerase II/EGFR-IN-1			Topoisomerase II
Anticancer agent 75			Topoisomerase II
CP-67804			Topoisomerase II
DTS-108		Top1
Pixantrone hydrochloride			Topoisomerase II
Topoisomerase II inhibitor 4			Topoisomerase II
Topoisomerase IIα-IN-6			topoisomerase II alpha, IC₅₀: 0.67 μM
Topoisomerase IIα-IN-2			topoisomerase II alpha topoisomerase II beta
Topoisomerase IIα-IN-4			topoisomerase II alpha, IC₅₀: 3.8 μM topoisomerase II beta, IC₅₀: 10.1 μM
ZLHQ-5f		Top1
3-Fluoro-evodiamine glucose		Topoisomerase I	Topoisomerase II
Topo I-IN-1		Topoisomerase I
Topoisomerase I/II inhibitor 6		Topoisomerase I, IC₅₀: 4.77 μM	Topoisomerase II, IC₅₀: 15 μM
Anti-SLC34A2 (Lifastuzumab)-MC-Vc-PAB-SN38		Topoisomerase I
EGFR-IN-116			Topoisomerase II, IC₅₀: 19.74 μM
Top/HDAC-IN-2		Top1	Topoisomerase II
Anti-MRSA agent 7	TOPO IV, IC₅₀: 0.059 μM (E. coli ) TOPO IV, IC₅₀: 0.341 μM (S. aureus)
Topoisomerase II inhibitor 18			Topoisomerase II, IC₅₀: 7.5 μM
Topoisomerase I inhibitor 17		Top1
Elomotecan		Topoisomerase I	Topoisomerase II
Topoisomerase II inhibitor 5			Topoisomerase II
LE01		Topoisomerase I
HSP90-IN-13	Topoisomerase-2, IC₅₀: 25.85 nM
Topoisomerase I inhibitor 2		Topoisomerase I, IC₅₀: 0.58 μM
iNOS/TopoI-IN-1		Topoisomerase I, Ki: 2.72 μM
Anti-CCL2 (Carlumab)-MC-Vc-PAB-SN38		Topoisomerase I
Topoisomerase II inhibitor 10			Topoisomerase II, IC₅₀: 7.45 μM
Salvicine			Topoisomerase II, IC₅₀: 3 μM
Topoisomerase IV inhibitor 1	TOPO IV, IC₅₀: 0.23 μM
Topoisomerase II inhibitor 13			Topoisomerase II	99.26%
EGFR-IN-57			topoisomerase II beta, IC₅₀: 0.13 μM
Topoisomerase IIα-IN-1			topoisomerase II alpha topoisomerase II beta
Huanglongmycin N		Topoisomerase I, EC₅₀: 14 μM
Topoisomerase IIα-IN-8			topoisomerase II alpha
Tilatamig samrotecan		Topoisomerase I
Deruxtecan-Eribulin		Topoisomerase I
CP-67015			Topoisomerase II
Tapcin		Topoisomerase I, IC₅₀: 203 nM	Topoisomerase II, IC₅₀: 71 nM
Topoisomerase I inhibitor 12		Topoisomerase I
Topoisomerase II inhibitor 17			Topoisomerase II, IC₅₀: 0.23 μM
Topoisomerase I/II inhibitor 2		Topoisomerase I	Topoisomerase II
Topo I/II-IN-2		Topoisomerase I	Topoisomerase II
Saintopin		Topoisomerase I	Topoisomerase II
Intoplicine dimesylate		Topoisomerase I	Topoisomerase II	98.28%
Topoisomerase IV inhibitor 2	TOPO IV, IC₅₀: 0.35 μM
Topoisomerase II inhibitor 7			topoisomerase II alpha, IC₅₀: 3.19 μM
Topoisomerase I/II inhibitor 7		Topoisomerase I	Topoisomerase II
Topoisomerase IIα-IN-7			topoisomerase II alpha, IC₅₀: 7.7 μM
Niranthin	Topoisomerase
Epolactaene			Topoisomerase II, IC₅₀: 10 μM
Topoisomerase I inhibitor 3		Topoisomerase I
Topoisomerase II inhibitor 19			Topoisomerase II, IC₅₀: 0.34 μM
Corydamine		Topoisomerase I	Topoisomerase II
TP0480066			Topoisomerase II
AZD5099			Topoisomerase II
Topoisomerase I inhibitor 16		Topoisomerase I
TP3011		Topoisomerase I
Topoisomerase II inhibitor 8			Topoisomerase II, IC₅₀: 0.52 μM
Topoisomerase I/II inhibitor 3		Topoisomerase I	Topoisomerase II
Gatifloxacin mesylate			Topoisomerase II, IC₅₀: 36.7 μM
Topoisomerase IIα-IN-5			topoisomerase II alpha
Bakuchicin			Topoisomerase II, IC₅₀: 404 μM
Thaspine acetate		Topoisomerase I	Topoisomerase II
Antibacterial agent 229	TOPO IV, IC₅₀: 10.88 μM
(-)-BO 2367			Topoisomerase II
8-Chloro-ATP tetrasodium			Topoisomerase II
Garenoxacin	TOPO IV, IC₅₀: 1.5-2.5 μg/mL
HU 331			Topoisomerase II
Luotonin F			Topoisomerase II
Topovale		Topoisomerase I
NK 314			topoisomerase II alpha
8-Chloro-ATP			Topoisomerase II

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Topoisomerase

Topoisomerase

Topoisomerase Isoform Specific Products:

Topoisomerase Isoform Specific Products:

Topoisomerase Related Products (585)

Antibodies (4)

Topoisomerase Isoform Comparison

Topoisomerase Related Products (585):