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Pathways Recommended:	Membrane Transporter/Ion Channel

Results for "

Ca channels

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (146) Chloride Channel (7) CRAC Channel (4) HCN Channel (2) Na+/Ca2+ Exchanger (6) Piezo Channel (2) Potassium Channel (55) Sodium Channel (30) TRP Channel (22) 5-HT Receptor (1) Acyltransferase (1) Adenosine Receptor (1) Adrenergic Receptor (1) Akt (1) Amino Acid Derivatives (1) AMPK (4) Amyloid-β (1) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (9) Autophagy (11) Bacterial (3) Calmodulin (2) Carbonic Anhydrase (2) Caspase (2) CDK (1) COX (4) DNA/RNA Synthesis (6) Dopamine Receptor (6) Drug Metabolite (2) Endogenous Metabolite (21) ERK (2) Estrogen Receptor/ERR (1) Fungal (1) GABA Receptor (10) Guanylate Cyclase (1) HDAC (2) Histamine Receptor (2) HIV (4) iGluR (18) Isotope-Labeled Compounds (18) mAChR (3) mGluR (2) Mineralocorticoid Receptor (1) Mitophagy (2) NF-κB (1) Parasite (10) Phosphodiesterase (PDE) (3) Phospholipase (3) PKA (7) PKC (6) PKG (2) Prostaglandin Receptor (1) Reactive Oxygen Species (1) ROCK (6) TGF-beta/Smad (6) Thyroid Hormone Receptor (1)
By Research Areas:	Cancer (46) Cardiovascular Disease (66) Endocrinology (7) Infection (10) Inflammation/Immunology (33) Metabolic Disease (31) Neurological Disease (110)
Oligonucleotides:	Flavoring Agents (1)

252

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Calcium Channel Na+/Ca2+ Exchanger CRAC Channel Chloride Channel HCN Channel TRP Channel Sodium Channel Potassium Channel Piezo Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17404

Cilnidipine 1 Publications Verification FRC-8653	Calcium Channel	Cardiovascular Disease
Cilnidipine is a long-acting, second-generation dihydropyridine Ca ²⁺-channel blocker on L and N-type Ca ²⁺ channel . Antihypertensive effects .

HY-101428

NS-638	Calcium Channel	Neurological Disease
NS-638 is a small nonpeptide molecule with Ca ²⁺-channel blocking properties. K ⁺-stimulated intracellular Ca ²⁺-elevation is blocked with an IC₅₀ value of 3.4 μM.

HY-110105

NS8593 hydrochloride	Potassium Channel	Neurological Disease
NS8593 hydrochloride is a potent and selective small conductance Ca ²⁺-activated K ⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca ²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca ²⁺), and does not affect the Ca ²⁺-activated K ⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively) .

HY-P1075

CALP3 2 Publications Verification	Calcium Channel	Neurological Disease Cancer
CALP3, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-17404R

Cilnidipine (Standard)	Calcium Channel	Cardiovascular Disease
Cilnidipine (Standard) is the analytical standard of Cilnidipine. This product is intended for research and analytical applications. Cilnidipine is a long-acting, second-generation dihydropyridine Ca ²⁺-channel blocker on L and N-type Ca ²⁺ channel . Antihypertensive effects .

HY-17404S

Cilnidipine-d7 FRC-8653-d₇	Isotope-Labeled Compounds Calcium Channel	Cardiovascular Disease
Cilnidipine-d₇ is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel[1][2][3][4]. Antihypertensive effects[5].

HY-121516

CM-TPMF	Others	Others
CM-TPMF is a K(Ca)2 channel modulator with selective activation and inhibition of K(Ca)2.1 subtypes. CM-TPMF can act on K(Ca)2.1 channels as an activator or inhibitor, and its activity is affected by the stereochemical structure. It can be used to study the physiological or pathophysiological effects of K(Ca)2.1 channels.

HY-164684

Dichlorobenzamil 3',4'-Dichlorobenzamil; L-594881	Calcium Channel Sodium Channel Na+/Ca2+ Exchanger	Others
Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective *Na/Ca* exchange inhibitor. Dichlorobenzamil significantly inhibits ⁴⁵Ca uptake mediated by reverse *Na/Ca* exchange in pancreatic islet cells (IC₅₀ = 18 μM). Dichlorobenzamil can also block K ⁺ channels and voltage-sensitive Ca ²⁺ channels .

HY-P5869

Kurtoxin	Calcium Channel Sodium Channel	Neurological Disease
Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca ²⁺ channel gating inhibitor with a K_d of 15 nM for Cav3.1 (α1G T-type) Ca ²⁺ channel. Kurtoxin can interact with high affinity with native neuronal high-threshold L-type, N-type, and P-type Ca ²⁺ channels in central and peripheral neurons. Kurtoxin also shows cross-reactivity with voltage-gated Na ⁺ channel .

HY-P5154

Tamapin	Potassium Channel	Neurological Disease
Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of SK2 (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-P1075A

CALP3 TFA	Calcium Channel	Neurological Disease Cancer
CALP3 TFA, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 TFA can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-41076

*Ca2+ channel* agonist 1**	Calcium Channel CDK	Neurological Disease
Ca ²⁺ channel agonist 1 is an agonist of N-type Ca ²⁺ channel and an inhibitor of Cdk2, with EC₅₀s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.

HY-12596

JNJ-26489112	Calcium Channel Sodium Channel Potassium Channel	Neurological Disease
JNJ-26489112, a CNS-active agent, exhibits broad-spectrum anticonvulsant activity in rodents against audiogenic, electrically-induced, and chemically-induced seizures. JNJ-26489112 inhibits voltage-gated Na ⁺ channels and N-type Ca ²⁺ channels, and is effective as a K ⁺ channel opener. JNJ-26489112 has very weak inhibition of CA-II (IC₅₀=35 μM) and CA-I (18 μM) .

HY-P5154A

Tamapin TFA	Potassium Channel	Neurological Disease
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of SK2 (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-10588

Bay K 8644 2 Publications Verification (±)-Bay K 8644	Calcium Channel	Cardiovascular Disease Neurological Disease
Bay K 8644 ((±)-Bay K 8644) is a racemate consisting of two isomers (R)-(+)-Bay-K-8644 and (S)-(-)-Bay-K-8644 . Bay K 8644 is a L-type Ca ²⁺ channel agonist with an EC₅₀ of 17.3 nM. Bay K 8644 increases Ca ²⁺ influx through sarcolemmal Ca ²⁺ channels by increasing the open time of the channel. Bay K 8644 has vasoconstrictive effects .

HY-14656

Diltiazem hydrochloride 5 Publications Verification CRD-401	Calcium Channel	Cardiovascular Disease Cancer
Diltiazem hydrochloride is a Ca ²⁺ influx inhibitor (slow channel blocker or calcium antagonist).

HY-19857

Sulcardine sulfate	Calcium Channel Potassium Channel Sodium Channel	Neurological Disease
Sulcardine (sulfate) is a novel multi-ion channel blocker with activity against Na ⁺, K ⁺ and Ca ²⁺ channels. Sulcardine has antiarrhythmic activity .

HY-147005

piCRAC-1	CRAC Channel	Cardiovascular Disease
piCRAC-1 is a potent, photoinducible Ca ²⁺ release-activated Ca ²⁺ (CRAC) channel inhibitor. piCRAC-1 alleviates thrombocytopenia and hemorrhage .

HY-U00026

Semotiadil recemate fumarate	Calcium Channel	Cardiovascular Disease
Semotiadil recemate fumarate is the recemate of Semotiadil fumarate. Semotiadil fumarate is a novel vasoselective Ca ²⁺ channel antagonist.

HY-15416

NS309	Potassium Channel	Cardiovascular Disease Neurological Disease
NS309 is a potent and selective activator of the Ca ²⁺-activated SK/IK potassium channels, but displays no activity at BK channels .

HY-U00212

Aranidipine MPC1304	Calcium Channel	Cardiovascular Disease
Aranidipine (MPC1304) is a Ca ²⁺ channel antagonist with potent and long-lasting antihypertensive effects.

HY-107319

Almitrine mesylate Almitrine bismesylate; Almitrine bismethanesulfonate; Almitrine dimesylate	Potassium Channel	Cardiovascular Disease Neurological Disease
Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca ²⁺-dependent K ⁺ channel.

HY-101360

1-EBIO 1-Ethyl-2-benzimidazolinone	Potassium Channel	Neurological Disease
1-EBIO is an activator of Ca ²⁺ sensitive K ⁺ channels. 1-EBIO is used to study the role of K ⁺ channels in diverse physiological functions .

HY-136909

SR33805	Calcium Channel	Cardiovascular Disease
SR33805 is a potent Ca ²⁺ channel antagonist, with EC₅₀s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca ²⁺ channels. SR33805 can be used for the research of acute or chronic failing hearts .

HY-19721

ABT-639 2 Publications Verification	Calcium Channel	Neurological Disease
ABT-639 is a novel, peripherally acting, selective T-type Ca ²⁺ channel blocker.

HY-101616

ABT-639 hydrochloride	Calcium Channel	Neurological Disease
ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca ²⁺ channel blocker.

HY-50694

Senicapoc 10+ Cited Publications ICa-17043	Potassium Channel	Others
Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca ²⁺-activated K ⁺ channel; KCa3.1) blocker with an IC₅₀ of 11 nM. Senicapoc blocks Ca ²⁺-induced rubidium flux from human RBCs with an IC₅₀ value of 11 nM and inhibits RBC dehydration with IC₅₀ of 30 nM .

HY-16952A

Bepridil hydrochloride hydrate 5 Publications Verification (±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate	Calcium Channel	Cardiovascular Disease
Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca ⁺ channel antagonist and Na ⁺, K ⁺ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac *Na ⁺/Ca2* ⁺ exchange (NCX1)** inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders .

HY-103313

SR33805 oxalate	Calcium Channel	Cardiovascular Disease
SR33805 oxalate is a potent Ca ²⁺ channel antagonist, with EC₅₀s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 oxalate blocks L-type but not T-type Ca ²⁺ channels. SR33805 oxalate can be used for the research of acute or chronic failing hearts .

HY-N0601

Ginsenoside Rf Panaxoside Rf	Calcium Channel Endogenous Metabolite	Neurological Disease Cancer
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca ²⁺ channel.

HY-B0493S1

Niflumic acid-13C6	Isotope-Labeled Compounds Chloride Channel	Inflammation/Immunology
Niflumic acid- ¹³C₆ is the ¹³C₆ labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

HY-108593

BMS-191011 3 Publications Verification BMS-A	Potassium Channel	Neurological Disease
BMS 191011 (BMS-A) is a potent BK_Ca channel opener (large-conductance Ca ²⁺-activated potassium channel). BMS-191011 shows neuroprotective activities in rodent models of stroke .

HY-131942

sFTX-3.3	Calcium Channel	Neurological Disease
sFTX-3.3 is a Ca ²⁺ channel antagonist with IC₅₀s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels .

HY-75161R

(-)-Menthol (Standard)	TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-110153

NS19504	Potassium Channel	Neurological Disease
NS19504 is a Ca ²⁺-activated K ⁺ channel (BK channel, KCa1.1 channel) activator (EC₅₀=11.0 µM) with relaxing effect on bladder smooth muscle spontaneous phasic contractions .

HY-100831

YM-58483 10+ Cited Publications BTP2	CRAC Channel	Inflammation/Immunology
YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca ²⁺ signals. YM-584832 is a blocker of store-operated Ca ²⁺ entry (SOCE) .

HY-12550

GW542573X	Potassium Channel	Neurological Disease
GW542573X is a potent and selective Ca ²⁺-activated K ⁺ 2 (SK2) channels activator. GW542573X induces the Ca ²⁺-response curve of hSK1 that left-shifted from an EC₅₀ (Ca ²⁺) value of 410 nM to 240 nM .

HY-103308

TRAM-39	Potassium Channel	Neurological Disease
TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IK_Ca) channels. TRAM-39 inhibits KCa3.1 channel with an IC₅₀ value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease .

HY-19608

GSK1016790A 20+ Cited Publications	TRP Channel Calcium Channel	Cardiovascular Disease Metabolic Disease
GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca ²⁺ influx and elevate intracellular Ca ²⁺ in HEK cells .

HY-B0493S

Niflumic Acid-d5	Chloride Channel	Inflammation/Immunology
Niflumic Acid-d₅ is the deuterium labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis[1][2].

HY-P3037

Imperatoxin A	Calcium Channel	Neurological Disease
Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca ²⁺-release channels/ryanodine receptors (RyRs) enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-W150752

Triphenylethylene	Estrogen Receptor/ERR Calcium Channel	Endocrinology
Triphenylethylene is an aromatic hydrocarbon that possesses weak estrogenic activity. Triphenylethylene antiestrogens relax duodenal intestinal muscle via a mechanism that involves inhibition of L-type Ca ²⁺ channels but not activation of K ⁺ channels .

HY-103307

FPL64176	Calcium Channel	Cardiovascular Disease
FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca ²⁺ channels with an EC₅₀ value of 16 nM .

HY-N3729

(-)-Denudatin B Denudatin B	Calcium Channel	Cardiovascular Disease
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels . And (-)-Denudatin B has nonspecific antiplatelet action

HY-126583

Nemadipine-A	Calcium Channel	Cancer
Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca ²⁺ channel . Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand .

HY-N7875

Celangulin	Others	Others
Celangulin is an insecticidal component isolated from Celastrus angulatus. Celangulin activates the calcium channel on the plasma membrane with increasing the intracellular Ca ²⁺ after influx from the external. Celangulin activates the calcium channel in the ER .

HY-12949

ML204 4 Publications Verification	TRP Channel	Neurological Disease
ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels .

HY-75161

(-)-Menthol 1 Publications Verification	TRP Channel Endogenous Metabolite	Cancer
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-P0190A

Iberiotoxin TFA	Potassium Channel	Others
Iberiotoxin (TFA) is a selective high conductance high conductance Ca ²⁺-activated K ⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin (TFA) does not block other types of voltage-dependent ion channels .

HY-12949A

ML204 hydrochloride 4 Publications Verification	TRP Channel	Neurological Disease
ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels .

Cat. No.	Product Name

HY-L166

Ion Channel Compound Library

1,208 compounds

Ion channel is a membrane-binding enzyme whose catalytic site is an ion conduction pore, which is opened and closed in response to specific environmental stimuli (voltage, ligand concentration, membrane tension, temperature, etc.). Ion channel provide pores for the passive diffusion of ions on the biofilm. Due to their high selectivity for ion, ion channel are generally classified as sodium (Na⁺ ), potassium (K⁺ ), calcium (Ca²⁺ ), chloride (Cl^- ), and non-specific cation channel. Ion channel is an important contributor to cell signal transduction and homeostasis. In addition to electrical signal transduction, ion channel also have many functions: regulating vascular smooth muscle contraction, maintaining normal cell volume, regulating glandular secretion, protein kinase activation, etc. Therefore, dysfunction of ion channel can lead to many diseases, and its mechanism research is particularly important.

MCE designs a unique collection of 1,208 small molecules related to ion channel, mainly targeting Na⁺ channel, K⁺ channel, Ca²⁺ channel, GABA receptor, iGluR, etc. It is an essential tool for research of cardiovascular diseases, Nervous system diseases and other diseases.

HY-L117

Calcium Channel Blocker Library

160 compounds

Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

MCE supplies a unique collection of 160 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

Cat. No.	Product Name	Type

HY-100168

BAPTA

20+ Cited Publications

Chelators

BAPTA is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-100168B

BAPTA tetrapotassium

20+ Cited Publications

Chelators

BAPTA tetrapotassium is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca ²⁺ release from intracellular stores or influx via Ca ²⁺-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca ²⁺ chelators .

HY-100545

BAPTA-AM Maximum Cited Publications 60 Publications Verification	Chelators
BAPTA-AM is a well-known membrane permeable Ca ²⁺ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC₅₀s of 1.3 μM, 1.45 μM and 1.23 μM, respectively .

Cat. No.	Product Name	Target	Research Area

HY-P1075

CALP3 2 Publications Verification	Calcium Channel	Neurological Disease Cancer
CALP3, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-P5154A

Tamapin TFA	Potassium Channel	Neurological Disease
Tamapin TFA is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin TFA is a selctive blocker of SK2 (Potassium Channel). Tamapin TFA inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin TFA can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-P0190A

Iberiotoxin TFA	Potassium Channel	Others
Iberiotoxin (TFA) is a selective high conductance high conductance Ca ²⁺-activated K ⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin (TFA) does not block other types of voltage-dependent ion channels .

HY-P3037A

Imperatoxin A TFA	Calcium Channel	Neurological Disease
Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. Imperatoxin A TFA is a Ca ²⁺-release channels/ryanodine receptors (RyRs) activator. Imperatoxin A TFA enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-P5869

Kurtoxin	Calcium Channel Sodium Channel	Neurological Disease
Kurtoxin is a selective Cav3 (T-type) voltage-gated Ca ²⁺ channel gating inhibitor with a K_d of 15 nM for Cav3.1 (α1G T-type) Ca ²⁺ channel. Kurtoxin can interact with high affinity with native neuronal high-threshold L-type, N-type, and P-type Ca ²⁺ channels in central and peripheral neurons. Kurtoxin also shows cross-reactivity with voltage-gated Na ⁺ channel .

HY-P5154

Tamapin	Potassium Channel	Neurological Disease
Tamapin is a venom peptide, targeting to small conductance Ca(2+)-activated K(+) (SK) channels. Tamapin is a selctive blocker of SK2 (Potassium Channel). Tamapin inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus. Tamapin can be isolated from the Indian red scorpion (Mesobuthus tamulus) .

HY-P1075A

CALP3 TFA	Calcium Channel	Neurological Disease Cancer
CALP3 TFA, a Ca ²⁺-like peptide, is a potent Ca ²⁺ channel blocker that activates EF hand motifs of Ca ²⁺-binding proteins. CALP3 TFA can functionally mimic increased [Ca ²⁺]_i by modulating the activity of Calmodulin (CaM), Ca ²⁺ channels and pumps. CALP3 TFA has the potential in controlling apoptosis in diseases such as AIDS or neuronal loss due to ischemia .

HY-P3037

Imperatoxin A	Calcium Channel	Neurological Disease
Imperatoxin A, a peptide toxin derived from the venom of the African scorpion Pandinus imperator, activator of Ca ²⁺-release channels/ryanodine receptors (RyRs) enhances the influx of Ca ²⁺ from the sarcoplasmatic reticulum into the cell .

HY-P1079

ω-Agatoxin TK	Calcium Channel	Neurological Disease
ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca ²⁺ channel blocker. ω-Agatoxin TK inhibits the high K ⁺ depolarisation-induced rise in internal Ca ²⁺ in cerebral isolated nerve endings with an IC₅₀ of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels .

HY-P1080

ω-Agatoxin IVA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA is a potent, selective P/Q type Ca ²⁺ (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca ²⁺ channels, respectively. ω-Agatoxin IVA (IC₅₀, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels .

HY-P0190

Iberiotoxin	Potassium Channel	Cardiovascular Disease
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca ²⁺-activated K ⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels .

HY-P1080A

ω-Agatoxin IVA TFA	Calcium Channel	Neurological Disease
ω-Agatoxin IVA TFA is a potent, selective P/Q type Ca ²⁺ (Cav2.1) channel blocker with IC₅₀s of 2 nM and 90 nM for P-type and Q-type Ca ²⁺ channels, respectively. ω-Agatoxin IVA TFA (IC₅₀, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA TFA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA TFA has no effect on L-type or N-type calcium channels .

HY-P3089

Dendrotoxin K	Potassium Channel	Others
Dendrotoxin K is a Kv1.1 channel blocker. Dendrotoxin K determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform .

HY-P5914

Wasabi Receptor Toxin WaTx	TRP Channel	Neurological Disease
Wasabi Receptor Toxin is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin is the activator for TRPA1 ion channel with EC₅₀ in nanomolar level, and prolongs the channel open time, but reduces Ca ²⁺ permeability. Wasabi Receptor Toxin causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .

HY-P3089A

Dendrotoxin K TFA	Potassium Channel	Others
Dendrotoxin K TFA is a Kv1.1 channel blocker. Dendrotoxin K TFA determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform .

HY-P5796

FS-2	Calcium Channel	Neurological Disease
FS-2 is a potent and specific L-type Ca_V channel inhibitor. FS-2 inhibits high K ⁺ or glucose induced L-type Ca ²⁺ influx in RIN beta cells .

HY-P1077

CALP1	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca ²⁺-binding site. CALP1 blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 activates CaM-dependent phosphodiesterase activity .

HY-P0256

Apamin 4 Publications Verification Apamine	Potassium Channel	Neurological Disease Inflammation/Immunology
Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca ²⁺-activated K ⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .

HY-P1077A

CALP1 TFA 1 Publications Verification	mGluR Phosphodiesterase (PDE) Apoptosis Calmodulin	Inflammation/Immunology
CALP1 TFA is a calmodulin (CaM) agonist (K_d of 88 µM) with binding to the CaM EF-hand/Ca ²⁺-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC₅₀ of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity .

HY-P0256A

Apamin TFA 4 Publications Verification Apamine TFA	Potassium Channel	Neurological Disease Inflammation/Immunology
Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca ²⁺-activated K ⁺ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity .

HY-P3156

Syringomycin E	Fungal	Infection
Syringomycin E is an antifungal cyclic lipodepsinonapeptide. Syringomycin E exhibits growth inhibition of Saccharomyces cerevisiae through interaction with the plasma membrane. Syringomycin E causes K ⁺ efflux, Ca ²⁺ influx, and changes in membrane potential, and is related to channel formation .

HY-P5319

MCaE12A	Peptides	Others
MCaE12A is a high-affinity modulator of RyR2 and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell .

HY-P3316

OSK-1	Potassium Channel	Neurological Disease Inflammation/Immunology
OSK-1 is a potent K_v channel blocker with IC₅₀s of of 0.6 nM, 5.4 nM, 0.014 nM for K_v1.1, K_v1.2 and K_v1.3, respectively. OSK1 is a moderate blocker of Ca ²⁺-activated K_Ca3.1 channel with an IC₅₀ of 225 nM. OSK-1 belongs to α-KTx3 toxins and is used as a immunosuppressive agent .

HY-P5914A

Wasabi Receptor Toxin TFA WaTx TFA	TRP Channel	Neurological Disease
Wasabi Receptor Toxin TFA (WaTx TFA) is the TFA salt form of Wasabi Receptor Toxin (HY-P5914). Wasabi Receptor Toxin TFA is a cell-penetrating scorpion toxin. Wasabi Receptor Toxin TFA is the activator for TRPA1 ion channel with EC₅₀ in nanomolar level, and prolongs the channel open time, but reduces Ca ²⁺ permeability. Wasabi Receptor Toxin TFA causes thermal hypersensitivity and mechanical allodynia in rats, without triggering neurogenic inflammation .

HY-P5870

KTX-Sp2	Potassium Channel	Inflammation/Immunology
KTX-Sp2 is a potassium channel toxin. KTX-Sp2 effectively blocks three types of exogenous voltage-gated potassium channels: Kv1.1, Kv1.2 and Kv1.3. Ktx-Sp2 inhibits endogenous Kv1.3 and suppresses Ca ²⁺ signaling in Jurkat T cells. Ktx-Sp2 inhibits IL-2 secretion from activated Jurkat T cells .

HY-P4160

PDC31 THG113.31; ILGHXDYK	Prostaglandin Receptor	Endocrinology
PDC31 (THG113.31; ILGHXDYK) is an allosteric and non-competitive inhibitor of FP Prostaglandin Receptor. PDC31 is the D-amino acid-based oligopeptide, is used for smooth muscle contractile agent. PDC31 decreases the strength and duration of uterine contractions in vivo, which can be used for research of preterm labor and primary dysmenorrhea (PD). PDC31 also enhances Ca ²⁺-dependent large-conductance K ⁺-channel in human myometrial cells .

HY-W111226

Fmoc-His(3-Me)-OH	Amyloid-β Amino Acid Derivatives	Cardiovascular Disease
Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC₅₀s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca ²⁺]_i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0601

Ginsenoside Rf Panaxoside Rf	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Endogenous metabolite Araliaceae	Calcium Channel Endogenous Metabolite
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca ²⁺ channel.

HY-N3729

(-)-Denudatin B Denudatin B	Cardiovascular Disease Classification of Application Fields Piper betle L. Source classification Lignans Piperaceae Phenylpropanoids Plants Disease Research Fields	Calcium Channel
(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels . And (-)-Denudatin B has nonspecific antiplatelet action

HY-75161

(-)-Menthol 1 Publications Verification	Structural Classification Natural Products Classification of Application Fields Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite Disease Research Fields Cancer	TRP Channel Endogenous Metabolite
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

HY-133168

Englerin A	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Cancer	TRP Channel
Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca ²⁺ influx and Ca ²⁺ cell overload .

HY-N2060

Evocarpine	Infection Alkaloids Structural Classification Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Quinoline Alkaloids Plants Inflammation/Immunology Disease Research Fields	Apoptosis Bacterial
Evocarpine, a quinolone alkaloid that could be isolated from Evodiae fructus, inhibitss Ca ²⁺ influx through voltage-dependent calcium channels. Antimycobacterial activity .

HY-135897

Urolithin C 4 Publications Verification	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields	Calcium Channel Reactive Oxygen Species Apoptosis Endogenous Metabolite
Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca ²⁺ channel opener and enhances Ca ²⁺ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation .

HY-75161R

(-)-Menthol (Standard)	Structural Classification Other Monoterpenes Human Gut Microbiota Metabolites Microorganisms Terpenoids Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite	TRP Channel Endogenous Metabolite
(-)-Menthol (Standard) is the analytical standard of (-)-Menthol. This product is intended for research and analytical applications. (-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i . Antitumor activity .

HY-N7875

Celangulin	Structural Classification Natural Products Source classification Celastraceae Celastrus angulatus Maxim. Plants	Others
Celangulin is an insecticidal component isolated from Celastrus angulatus. Celangulin activates the calcium channel on the plasma membrane with increasing the intracellular Ca ²⁺ after influx from the external. Celangulin activates the calcium channel in the ER .

HY-142050

(R)-IDHP	Structural Classification Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants	Calcium Channel
(R)-IDHP is an isomer of IDHP, a salvia metabolite that exerts vasorelaxant effects by inhibiting Ca ²⁺ release and Ca ²⁺ inward flow in voltage-dependent and receptor-operated calcium channels in vascular smooth muscle cells. IDHP is used in studies of cardiovascular disease .

HY-P0190

Iberiotoxin	Cardiovascular Disease Structural Classification Natural Products Animals Classification of Application Fields Source classification Disease Research Fields	Potassium Channel
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca ²⁺-activated K ⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels .

HY-116330AR

Hyperforin dicyclohexylammonium salt (Standard)	Structural Classification Natural Products Guttiferae Source classification Hyperlcurn perforatum L. Plants	TRP Channel Calcium Channel
Hyperforin (dicyclohexylammonium salt) (Standard) is the analytical standard of Hyperforin (dicyclohexylammonium salt). This product is intended for research and analytical applications. Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-N0601R

Ginsenoside Rf (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Endogenous metabolite Araliaceae	Calcium Channel Endogenous Metabolite
Ginsenoside Rf (Standard) is the analytical standard of Ginsenoside Rf. This product is intended for research and analytical applications. Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.

HY-133168R

Englerin A (Standard)	Structural Classification other families Terpenoids Sesquiterpenes Source classification Plants	TRP Channel
Englerin A (Standard) is the analytical standard of Englerin A. This product is intended for research and analytical applications. Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload .

HY-116330A

Hyperforin dicyclohexylammonium salt 1 Publications Verification Hyperforin DCHA	Structural Classification Natural Products Guttiferae Source classification Hyperlcurn perforatum L. Plants	TRP Channel Calcium Channel
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-N6778

Paxilline 5+ Cited Publications	Alkaloids Structural Classification Microorganisms other families Neurological Disease Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Indole Alkaloids	Potassium Channel Calcium Channel
Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca ²⁺ ATPase (SERCA) with IC₅₀s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity .

HY-N6688

Verruculogen	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Potassium Channel Bacterial Antibiotic
Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. and causes severe tremors in affected animals. Verruculogen inhibits Ca ²⁺-activated K ⁺ channels. Verruculogen is an M phase inhibitor of the mammalian cell cycle .

HY-N2549

(±)-Abscisic acid (±)-ABA	Structural Classification Natural Products other families Classification of Application Fields Source classification Metabolic Disease Abscisic acid Plants Phytohormone Disease Research Fields Agricultural Research	Calcium Channel
(±)-Abscisic acid ((±)-ABA) is an orally active phytohormone. (±)-Abscisic acid induces Ca ²⁺ channel opening to facilitate the influx of calcium ions and modulates stomatal movement. (±)-Abscisic acid shows anti-inflammatory activity and has the potential for the research of inflammatory bowel disease (IBD) .

HY-116330

Hyperforin	Structural Classification Anti-inflammation/Immunoregulatory Antibiotics Guttiferae Source classification Hyperlcurn perforatum L. Disease Research Plants Anticancer	Calcium Channel TRP Channel
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-N4267

Yangambin	Cardiovascular Disease other families Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Disease Research Fields	Calcium Channel
Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca ²⁺ influx through voltage-gated Ca ²⁺ channels, leading to the reduction in [Ca ²⁺]i in vascular smooth muscle cells and consequent peripheral vasodilation . Yangambin exhibits the antiallergic activity against β-hexosaminidase release with an IC₅₀ of 33.8 μM and for anti-inflammatory activity with an IC₅₀ of 37.4 μM .

HY-N1584

Halofuginone 10+ Cited Publications RU-19110	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Saxifragaceae Plants Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N0219

Bicuculline Maximum Cited Publications 21 Publications Verification (+)-Bicuculline; d-Bicuculline	Alkaloids Structural Classification Source classification Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae	GABA Receptor
Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA_A receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca ²⁺ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-N9404

6-Benzoylheteratisine	Alkaloids Piperidine Alkaloids Structural Classification Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Sodium Channel
6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na ⁺]i, [Ca ²⁺]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge .

HY-N1584A

Halofuginone hydrobromide 10+ Cited Publications RU-19110 hydrobromide	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Dichroa febrifuga Lour Source classification Saxifragaceae Plants Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-N0252

Catharanthine (+)-3,4-Didehydrocoronaridine	Apocynaceae Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits *voltage-operated L-type Ca ²⁺ channel* (VOCC)**. Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity .

HY-N0219R

Bicuculline (Standard)	Alkaloids Structural Classification Source classification Lamprocapnos spectabilis (L.) Fukuhara Plants Isoquinoline Alkaloids Papaveraceae	GABA Receptor
Bicuculline (Standard) is the analytical standard of Bicuculline. This product is intended for research and analytical applications. Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABAA receptor antagonist (IC₅₀=2 μM). Bicuculline also blocks Ca2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice .

HY-N1584AR

Halofuginone hydrobromide (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Dichroa febrifuga Lour Source classification Saxifragaceae Plants	DNA/RNA Synthesis TGF-beta/Smad Parasite Sodium Channel Calcium Channel
Halofuginone (hydrobromide) (Standard) is the analytical standard of Halofuginone (hydrobromide). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a K_i of 18.3 nM . Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity . Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca ²⁺ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects .

HY-B1671

(+)-Kavain	Structural Classification Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants	GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-N0252A

Catharanthine Tartrate (+)-3,4-Didehydrocoronaridine Tartrate	Apocynaceae Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Cancer	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits *voltage-operated L-type Ca ²⁺ channel* (VOCC)**. Catharanthine Tartrate has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR). Catharanthine Tartrate has anti-cancer activity .

HY-N0252B

Catharanthine Sulfate (+)-3,4-Didehydrocoronaridine Sulfate	Cardiovascular Disease Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don	Calcium Channel
Catharanthine ((+)-3,4-Didehydrocoronaridine) Sulfate, a constituent of anticancer vinca alkaloids, inhibits *voltage-operated L-type Ca ²⁺ channel* (VOCC)**. Catharanthine Sulfate has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Sulfate lowers blood pressure (BP), heart rate (HR). Catharanthine Sulfate has anti-cancer activity .

HY-N1369R

Menthol (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Labiatae Source classification Erythrina poeppigiana Plants Endogenous metabolite	Calcium Channel
Menthol (Standard) is the analytical standard of Menthol. This product is intended for research and analytical applications. Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-N0215

L-Phenylalanine 2 Publications Verification Phenylalanine	Structural Classification Microorganisms Animals Classification of Application Fields Source classification Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields	Calcium Channel iGluR Endogenous Metabolite
L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca ⁺ channels antagonist with a K_i of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (K_B of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

HY-B1671R

(+)-Kavain (Standard)	Structural Classification Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants	GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels . (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-N0252R

Catharanthine (Standard)	Apocynaceae Alkaloids Structural Classification Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don	Calcium Channel
Catharanthine (Standard) is the analytical standard of Catharanthine. This product is intended for research and analytical applications. Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine has IC₅₀s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity .

HY-N0215R

L-Phenylalanine (Standard)	Structural Classification Microorganisms Animals Source classification Amino acids Endogenous metabolite	Calcium Channel iGluR Endogenous Metabolite
L-Phenylalanine (Standard) is the analytical standard of L-Phenylalanine. This product is intended for research and analytical applications. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals .

HY-N7690

3,5,7,3′,4′-Pentamethoxyflavone	Structural Classification Flavonoids Classification of Application Fields Flavones Metabolic Disease Plants Disease Research Fields Zingiberaceae	Calcium Channel
3,5,7,3’,4’-Pentamethoxyflavone is a Ca ²⁺ channel inhibitor. 3,5,7,3’,4’-Pentamethoxyflavone can protect DNA from oxidative damage. 3,5,7,3’,4’-Pentamethoxyflavone can induce relaxation of the human corpus cavernosum through calcium mobilization-related mechanisms. 3,5,7,3’,4’-Pentamethoxyflavone can promote the expression of eNOS and cystathionine gamma lyase CSE proteins in middle-aged male rats and regulate vascular function. 3,5,7,3’,4’-Pentamethoxyflavone can be used in research related to diabetes and cardiovascular diseases .

HY-B0561

Spironolactone 3 Publications Verification SC9420	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Mineralocorticoid Receptor Androgen Receptor Autophagy Calcium Channel
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (AngⅡ)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type Ⅱ diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

Cat. No.	Product Name	Chemical Structure

HY-B0493S1

Niflumic acid-13C6
Niflumic acid- ¹³C₆ is the ¹³C₆ labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis.

HY-14656S

Diltiazem-d3 hydrochloride
Diltiazem-d₃ (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-B1221S1

Flufenamic acid-13C6

Flufenamic acid- ¹³C₆ is the ¹³C₆ labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-17404S

Cilnidipine-d7
Cilnidipine-d₇ is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel[1][2][3][4]. Antihypertensive effects[5].

HY-B0493S

Niflumic Acid-d5
Niflumic Acid-d₅ is the deuterium labeled Niflumic acid. Niflumic acid, a Ca2+-activated Cl- channel blocker, is an analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis[1][2].

HY-14656S1

Diltiazem-(acetoxy-d3) (hydrochloride)
Diltiazem-(acetoxy-d₃) (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].

HY-B1221S

Flufenamic acid-d4

Flufenamic acid-d₄ is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca ²⁺ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

HY-A0057AS2

Gabapentin-d4 hydrochloride
Gabapentin-d4 hydrochloride is the deuterium labeled Gabapentin hydrochloride (HY-A0057A). Gabapentin hydrochloride is a potent, orally active P/Q type Ca ²⁺ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca ²⁺ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain .

HY-B0632S

Diltiazem-d6
Diltiazem-d₆ is the deuterium labeled Diltiazem. Diltiazem is an orally active L-type Ca2+ channel blocker, with antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris[1][2][3].

HY-103309S

ML218-d9

ML218-d₉ is the deuterium labeled ML218. ML218 is a potent, selective and orally active T-type Ca2+ channels (Cav3.1, Cav3.2, Cav3.3) inhibitor with IC50s of 310 nM and 270 nM for Cav3.2 and Cav3.3, respectively. ML218 inhibits the burst activity in subthalamic nucleus (STN) neurons. ML218 has no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. ML218 can penetrate the blood-brain barrier[1].

HY-B0358AS

Flunarizine-d8 dihydrochloride
Flunarizine-d₈ dihydrochloride is deuterated labeled Flunarizine dihydrochloride (HY-B0358A). Flunarizine dihydrochloride is a potent dual *Na ⁺/Ca* ²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine** receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-N9484S

Menthofuran-13C2

Menthofuran- ¹³C₂ is ¹³C labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca ⁺⁺ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice .

HY-N0215S6

DL-Phenylalanine-d5 hydrochloride

DL-Phenylalanine-d₅ (hydrochloride) is the deuterium labeled DL-Phenylalanine hydrochloride. L-Phenylalanine hydrochloride is an essential amino acid isolated from Escherichia coli. L-Phenylalanine hydrochloride is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine hydrochloride is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine hydrochloride is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S13

L-Phenylalanine-d1

L-Phenylalanine-d is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S3

L-Phenylalanine-d2

L-Phenylalanine-d₂ is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S2

L-Phenylalanine-13C

L-Phenylalanine- ¹³C is the ¹³C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S

L-Phenylalanine-d7

L-Phenylalanine-d₇ is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S1

L-Phenylalanine-d8

L-Phenylalanine-d₈ is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S5

L-Phenylalanine-15N

L-Phenylalanine- ¹⁵N is the ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S10

L-Phenylalanine-13C9

L-Phenylalanine- ¹³C₉ is the ¹³C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S12

L-Phenylalanine-d5

1 Publications Verification

L-Phenylalanine-d₅ is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S7

L-Phenylalanine-3-13C

L-Phenylalanine-3- ¹³C is the ¹³C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S8

L-Phenylalanine-13C6

L-Phenylalanine- ¹³C₆ is the ¹³C-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S11

L-Phenylalanine-13C9,15N

L-Phenylalanine- ¹³C₉, ¹⁵N is the ¹³C- and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S14

L-Phenylalanine-15N,d8

L-Phenylalanine- ¹⁵N,d₈ is the deuterium and ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-N0215S9

L-Phenylalanine-13C9,15N,d8

L-Phenylalanine- ¹³C₉, ¹⁵N,d₈ is the deuterium, ¹³C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

Cat. No.	Product Name		Classification

HY-75161

(-)-Menthol 1 Publications Verification		Flavoring Agents
(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca ²⁺-permeable nonselective cation channel, to increase [Ca ²⁺]_i . Antitumor activity .

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