Search Result

Results for "

Na

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/Ca2+ Exchanger (14) Na+/H+ Exchanger (NHE) (18) Na+/HCO3- Cotransporter (1) Na+/K+ ATPase (58) NKCC (8) Sodium Channel (94) 5-HT Receptor (2) Adrenergic Receptor (11) Akt (1) Amyloid-β (1) Angiotensin Receptor (3) Antibiotic (6) Apical Sodium-Dependent Bile Acid Transporter (1) Apoptosis (27) Aryl Hydrocarbon Receptor (1) ASCT (1) Atg8/LC3 (1) Autophagy (29) Bacterial (14) Beclin1 (1) Biochemical Assay Reagents (10) Bradykinin Receptor (3) Calcium Channel (23) Calmodulin (2) Carbonic Anhydrase (1) Chloride Channel (2) Cholinesterase (ChE) (2) COX (3) DNA/RNA Synthesis (1) Dopamine Receptor (6) Drug Metabolite (2) EAAT (2) EBV (1) Elastase (1) Endogenous Metabolite (18) Enteropeptidase (1) ERK (3) Ferroptosis (1) Fluorescent Dye (6) Fungal (7) G protein-coupled Bile Acid Receptor 1 (2) GABA Receptor (10) Glucosidase (6) GlyT (4) GPR109A (1) Guanylate Cyclase (1) HDAC (2) HIV (4) HPV (1) HSV (2) iGluR (3) IKK (4) Imidazoline Receptor (4) Indoleamine 2,3-Dioxygenase (IDO) (2) Influenza Virus (23) IRAK (2) Isotope-Labeled Compounds (12) JNK (1) Liposome (2) LXR (1) LYTACs (1) mAChR (3) Melanocortin Receptor (1) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (4) Mitophagy (4) nAChR (1) NF-κB (8) NO Synthase (3) P2X Receptor (1) p38 MAPK (1) Parasite (5) Phosphodiesterase (PDE) (4) PKA (1) PKC (1) PKD (1) Potassium Channel (22) Prostaglandin Receptor (2) PROTAC Linkers (1) Proteasome (1) Proton Pump (5) RSV (1) SARS-CoV (1) Serotonin Transporter (3) SGLT (3) Src (2) STAT (1) STING (1) Thrombin (1) Thyroid Hormone Receptor (1) TRP Channel (2) Virus Protease (5) Wnt (3)
By Research Areas:	Cancer (81) Cardiovascular Disease (72) Endocrinology (5) Infection (42) Inflammation/Immunology (43) Metabolic Disease (63) Neurological Disease (121)
Oligonucleotides:	Disintegrants (1) Suspending Agents (1) Emulsifiers (1) Phospholipids (2) Binders (1)

342

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Na+/HCO3- Cotransporter Na+/Ca2+ Exchanger Na+/K+ ATPase Na+/H+ Exchanger (NHE) Sodium Channel NKCC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155482

NA-184	Proteasome Others	Neurological Disease
NA-184 is a selective calpain-2 inhibitor. NA-184 inhibits TBI-induced cell death with an EC₅₀ of 0.13 mg/kg .

HY-162455

NA-014	EAAT	Others
NA-014 (40) is a selective EAAT2 positive allosteric modulator (PAM), with an EC₅₀ of 3 nM .

HY-B1039

Ambroxol 2 Publications Verification Na-872	Glucosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol (NA-872), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-B1039A

Ambroxol hydrochloride 2 Publications Verification Na-872 hydrochloride	Glucosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-B1039AS

Ambroxol-d5 hydrochloride Na-872-d₅ hydrochloride	Isotope-Labeled Compounds Glucosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol-d₅ (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

HY-N10627

NA2 Glycan	Others	Others
NA2 Glycan is NA2 N-linked oligosaccharide. NA2 is the asialo-substructure of A2 glycan. NA2 glycan can be isolated from mammalian serum glycoproteins, such as serum IgG .

HY-161397

NA-1-157	Bacterial	Infection Inflammation/Immunology
NA-1-157 is a potent irreversible covalent inhibitor of the GES-5 carbapenemase, with a MIC of 0.5 μg/mL .

HY-162944

NA-Ir	Ferroptosis Mitochondrial Metabolism STING Autophagy	Cancer
NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H₂S levels .

HY-B1039AR

Ambroxol hydrochloride (Standard) Na-872 hydrochloride (Standard)	Glucosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol (hydrochloride) (Standard) is the analytical standard of Ambroxol (hydrochloride). This product is intended for research and analytical applications. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-B1039C

Ambroxol (acefylline) Na-872 (acefylline); Acebrophylline	Glucosidase Autophagy	Neurological Disease Metabolic Disease
Ambroxol (NA-872) acefylline, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol acefylline is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol acefylline induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research .

HY-103332

N-Arachidonylglycine 1 Publications Verification Na-Gly	GlyT Endogenous Metabolite	Inflammation/Immunology
N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC₅₀ = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC₅₀ = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .

HY-103332S

N-Arachidonylglycine-d8 Na-Gly-d₈	Isotope-Labeled Compounds Endogenous Metabolite GlyT	Inflammation/Immunology
N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine . N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC₅₀ = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC₅₀ = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .

HY-P0117

Tat-NR2B9c 5+ Cited Publications Tat-NR2Bct; Na-1	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits?neuronal nitric oxide synthase (nNOS)/PSD-95?interaction, and possesses neuroprotective efficacy .

HY-132133

Nav1.8-IN-1	Sodium Channel	Neurological Disease Inflammation/Immunology
Nav1.8-IN-1 (Compound 31) is a potent inhibitor of Na(v)1.8 sodium channel. Nav1.8-IN-1 has the potential for the research of inflammatory and neuropathic pain .

HY-160663

Nav1.7 blocker 1	Sodium Channel	Neurological Disease Inflammation/Immunology
Nav1.7 blocker 1 (example 41) is a Na ⁺ channel (Na_v) blocker with an IC₅₀ value of 0.037 μM. Nav1.7 blocker 1 can be used for the study of pain, including neuropathic pain, postoperative pain, inflammatory pain, and so on .

HY-P0117A

Tat-NR2B9c TFA 5+ Cited Publications Tat-NR2Bct TFA; Na-1 TFA	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .

HY-162347

Nav1.7-IN-13	Sodium Channel	Neurological Disease
Nav1.7-IN-13 (compound 3g) is a sodium channel inhibitor that significantly inhibits Veratridine (HY-N6691)-induced neuronal activity. Nav1.7-IN-13 inhibits total Na+ current in DRG neurons in a concentration-dependent manner; slows down the activation of Navs. Nav1.7-IN-13 significantly alleviated mechanical pain behavior in a rat model of nerve injury (SNI) and had analgesic activity .

HY-B1604

Chloroprocaine hydrochloride 2-Chloroprocaine hydrochloride	Na+/K+ ATPase	Neurological Disease
Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of *Na,K-ATPase* activity with an IC₅₀ of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve .

HY-B1604A

Chloroprocaine 2-Chloroprocaine	Na+/K+ ATPase	Neurological Disease
Chloroprocaine (2-Chloroprocaine) is a potent inhibitor of *Na,K-ATPase* activity with an IC₅₀ of 13 mM. Chloroprocaine blocks peripheral nerve .

HY-B1604R

Chloroprocaine hydrochloride (Standard)	Na+/K+ ATPase	Neurological Disease
Chloroprocaine (hydrochloride) (Standard) is the analytical standard of Chloroprocaine (hydrochloride). This product is intended for research and analytical applications. Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve .

HY-160656

5-HT/NA Reuptake inhibitor-1	5-HT Receptor	Neurological Disease
5-HT/NA Reuptake inhibitor-1 (compound 9) is a selective dual 5-HT and NA reuptake inhibitor with IC₅₀ of 660 nM and 70 nM respectively. . 5-HT/NA Reuptake inhibitor-1 has good in vitro human metabolic stability, hERG selectivity and passive membrane permeability .

HY-140340

Fmoc-NH-pentanoic acid-NHS-SO3Na	PROTAC Linkers	Cancer
Fmoc-NH-pentanoic acid-NHS-SO3Na is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-P1920

CEF19, Epstein-Barr Virus latent NA-3A (458-466)	EBV	Inflammation/Immunology
CEF19, Epstein-Barr Virus latent NA-3A (458-466) is a single peptide epitope, YPLHEQHGM, representing residues 458-466 of the type 1 Epstein-Barr Virus (EBV) nuclear antigen 3A protein (B95.8 strain). CEF19, Epstein-Barr Virus latent NA-3A (458-466) can significantly affect cytotoxic T-lymphocyte (CTL) recognition .

HY-151104

Neuraminidase-IN-11	Influenza Virus	Infection
Neuraminidase-IN-11 (15e) is a potent and selective neuraminidase (NA) inhibitor with the IC₅₀ values of 4.7 nM, 8.46 nM and 1.5 nM against H1N1, H5N1 and H5N8 NAs respectively .

HY-Y1889A

Sodium carboxymethyl cellulose (MW 250000) 5+ Cited Publications CMC-Na (MW 250000); CMC-Na (Viscosity:1500-3100 mPa.s)	Biochemical Assay Reagents	Others
Sodium carboxymethyl cellulose (CMC-Na) (MW 250000) is a sodium salt of carboxymethyl cellulose. Sodium carboxymethyl cellulose has adsorption and corrosion inhibition on low-carbon steel in an acidic medium. Sodium carboxymethyl cellulose can be used as a thickener, paste and barrier agent .

HY-120482

CHM-1-P-Na	Others	Others
CHM-1-P-Na is a sodium monophosphate salt of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one, which can be converted into CHM-1, a compound with a unique anti-tumor mechanism, in vitro and in vivo, and has excellent anti-tumor activity in tumor models and clear pharmacological effects on related enzymes.

HY-13941B

1-Naphthyl PP1 hydrochloride 1 Publications Verification 1-Na-PP 1 hydrochloride	Src	Cancer
1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC₅₀s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively .

HY-13941

1-Naphthyl PP1 1 Publications Verification 1-Na-PP 1	Src PKD	Cancer
1-Naphthyl PP1 (1-NA-PP 1) is a selective inhibitor of src family kinases and Protein Kinase D. 1-Naphthyl PP1 inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC₅₀s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively .

HY-P2660

Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide GD4K-Na	Enteropeptidase	Others
Gly-Asp-Asp-Asp-Asp-Lys-β-naphthylamide (GD4K-na) is a substrate for human enteropeptidase (K_m: 0.16 mM) .

HY-W718136

D-Glucosamine 6-phosphate sodium GlcN6P-Na	Biochemical Assay Reagents	Others
D-Glucosamine 6-phosphate (sodium) (GlcN6P-Na) is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W040263

TAPS sodium TAPS Na	Biochemical Assay Reagents	Others
TAPS sodium is a biological buffer that protects the structural integrity of lysozyme bacteria and prevents them from thermal denaturation at high temperatures. A pKa of 8.1 for TAPS results in half-maximal connexin channel activity .

HY-126831

SBFI-AM 2 Publications Verification	Fluorescent Dye	Others
SBFI-AM is a Na ⁺ selective fluorescent indicator. SBFI-AM shows selectivity for Na ⁺ over K ⁺ .

HY-131899

N-Bromoacetamide	Potassium Channel Sodium Channel	Others
N-Bromoacetamide can irreversibly remove sodium channel inactivation in the cytoplasmic face of the membrane, also decreasing K current rapid inactivation .

HY-19062

SM-6586	Calcium Channel Na+/Ca2+ Exchanger	Cardiovascular Disease
SM-6586 is a calcium channel antagonist and inhibitor of Na ⁺/H ⁺ and Na ⁺/Ca ²⁺ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

HY-124925

Vincanol (-)-IsoeburNamine; (-)-epi-EburNamine	Sodium Channel	Neurological Disease
Vincanol ((-)-Isoeburnamine) is a blocker of voltage-gated Na+ channels. Vincanol blocks Na ⁺ currents with an IC₅₀ value of 40 μM. Vincanol has neuroprotective effect .

HY-137172

ETH 157	Others	Others
ETH 157 is a Na ⁺ selective microelectrode based on a synthetic neutral carrier that is selective enough for K ⁺, Ca ²⁺, and Mg ²⁺ for extracellular measurements of Na+ activity .

HY-163522

Neuraminidase-IN-20	Influenza Virus	Infection
Neuraminidase-IN-20 (Compound 5i) is a potent inhibitor of mutant neuraminidase (NA) (H5N1-H274Y) (IC₅₀= 0.44 μM).Neuraminidase-IN-20 binds to the 430 cavity site of NA and disrupts the enzymatic activity of NA .

HY-15754

CGP37157 5 Publications Verification	Na+/Ca2+ Exchanger	Neurological Disease Cancer
CGP37157 is a potent, selective inhibitor of Na ⁺/Ca ²⁺ exchanger, inhibiting the Na ⁺-induced Ca ²⁺-release from guinea-pig heart mitochondria, with an IC₅₀ of 0.8 μM.

HY-163393

Neuraminidase-IN-18	Influenza Virus	Infection
Neuraminidase-IN-18 (compound N5) is a novel polyheterocyclic neuraminidase (NA) inhibitor. Neuraminidase-IN-18 shows potency in inhibition of H5N1 NA with an IC₅₀ of 0.14 μM and 0.27 μM against the wild-type H5N1 NA and H5N1-H274Y mutant NA, respectively. Neuraminidase-IN-18 inhibits influenza virus replication by binding to NAs in cell level .

HY-D1760

Sodium-binding benzofuran isophthalate	Fluorescent Dye	Others
SBFI is a cell-impermeant, fluorescent Na ⁺ indicator dye. SBFI is excited at 340 nm and the fluorophore emission is collected at 450 nm . SBFI selective for Na ⁺ over K ⁺ with K_d values of 20 and 120 mM for these ions, respectively. .

HY-15515

SEA0400 15+ Cited Publications	Na+/Ca2+ Exchanger	Cardiovascular Disease
SEA0400 is a novel and selective inhibitor of the Na ⁺-Ca ²⁺ exchanger (NCX), inhibiting Na ⁺-dependent Ca ²⁺ uptake in cultured neurons, astrocytes, and microglia with IC₅₀s of from 5 to 33 nM.

HY-17015

Peramivir trihydrate 5+ Cited Publications RWJ 270201 trihydrate; BCX 1812 trihydrate	Influenza Virus IKK JNK STAT p38 MAPK ERK	Infection Inflammation/Immunology
Peramivir trihydrate (RWJ-270201 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC₅₀ values ranging from 0.9 to 4.3 nM for nine NA subtypes .

HY-14818

Laninamivir 4 Publications Verification R 125489	Influenza Virus	Infection
Laninamivir (R 125489) is a potent influenza neuraminidase (NA) inhibitor with IC₅₀s of 0.90 nM, 1.83 nM and 3.12 nM for avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2), respectively .

HY-19693

Cariporide 5+ Cited Publications HOE-642 Free Base	Na+/H+ Exchanger (NHE)	Cardiovascular Disease Inflammation/Immunology Cancer
Cariporide (HOE-642) is a selective Na ⁺/H ⁺ exchange inhibitor.

HY-106150B

Eniporide hydrochloride 1 Publications Verification EMD-96785 hydrochloride	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Eniporide hydrochloride (EMD-96785 hydrochloride) is a potent Na ⁺/H ⁺ exchange inhibitor.

HY-19298

S-8921	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
S-8921 is an ileal Na ⁺/bile acid cotransporter (IBAT) inhibitor.

HY-145154

Digoxigenin monodigitoxoside	Na+/K+ ATPase	Metabolic Disease
Digoxigenin monodigitoxoside is a Na+/K+ ATPase inhibitor and cardiac glycoside metabolite of digoxin.

HY-123679

FR168888	Na+/H+ Exchanger (NHE)	Cardiovascular Disease Inflammation/Immunology
FR168888 is an inhibitor of Na+/H+ exchange with a K_i value of 6.4 nM .

HY-121233

Chloropropylate	Na+/K+ ATPase	Infection
Chloropropylate is an acaricide agent that can inhibit Mg ²⁺ and Na ⁺K ⁺-ATPase .

HY-75839

Dronedarone Hydrochloride 1 Publications Verification	Potassium Channel Autophagy	Cardiovascular Disease
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na ⁺, K ⁺ and Ca ²⁺ currents.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-103332

N-Arachidonylglycine 1 Publications Verification Na-Gly	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	GlyT Endogenous Metabolite
N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC₅₀ = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC₅₀ = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .

HY-13719

Oleandrin 3 Publications Verification PBI-05204	Apocynaceae Structural Classification Classification of Application Fields Source classification Nerium indicum Mill. Plants Disease Research Fields Steroids Cancer	Na+/K+ ATPase
Oleandrin (PBI-05204) inhibits the Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 620 nM.

HY-N6574

Marinobufogenin	Classification of Application Fields Neurological Disease Animals Source classification Metabolic Disease Disease Research Fields Steroids	Na+/K+ ATPase
Marinobufogenin is a strong inhibitor of Na ⁺/K ⁺ ATPase that has been identified in mammalian plasma .

HY-N1446B

Sodium oleate Maximum Cited Publications 28 Publications Verification Oleic acid sodium; 9-cis-Octadecenoic acid sodium; 9Z-Octadecenoic acid sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Na+/K+ ATPase Apoptosis
Sodium oleate (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium . Sodium oleate is a Na ⁺/K ⁺ ATPase activator .

HY-N6745

Citreoviridin	Cardiovascular Disease Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Na+/K+ ATPase Apoptosis
Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-12545

Brevetoxin-3 PbTx-3	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Sodium Channel
Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na ⁺?channel activator and has multiple active centers (A-ring lactone, C-42 of R side chain) . Brevetoxin-3 (PbTx-3) has a high affinity to site 5 of the voltage-sensitive Na ⁺?channels, inhibits the inactivation of Na ⁺ channels and prolongs the mean open time of these channels. Brevetoxin-3 (PbTx-3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation .

HY-N0736

Coptisine chloride 5+ Cited Publications	Infection Alkaloids Structural Classification Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields	Indoleamine 2,3-Dioxygenase (IDO) Bacterial Influenza Virus
Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a K_i value of 5.8 μM and an IC₅₀ value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC₅₀ of 104.6?μg/mL and can be used for influenza A (H1N1) infection.

HY-114252

Strophanthidin	Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Plants Brassicaceae Disease Research Fields Steroids Erysimum cheiranthoides Linn.	Na+/K+ ATPase
Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the *Na+/K+-ATPase* activities, but Strophanthidin 10 and 100 nmol/L does not affect *Na+/K+-ATPase* activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca ²⁺ concentration .

HY-N1446

Oleic acid Maximum Cited Publications 28 Publications Verification 9-cis-Octadecenoic acid; 9Z-Octadecenoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Na+/K+ ATPase Endogenous Metabolite Apoptosis
Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid . Oleic acid is a Na ⁺/K ⁺ ATPase activator .

HY-118367

A 80915A	Structural Classification Microorganisms Antibiotics Source classification	Na+/K+ ATPase Proton Pump
A 80915A is a seminaphthoquinone produced by Streptomyces and is a potent inhibitor of Na+/K+ ATPase involved in gastric acid secretion.

HY-N11690

Oleandrigenin	Apocynaceae Structural Classification Natural Products Source classification Nerium indicum Mill. Plants	Na+/K+ ATPase
Oleandrigenin is a potent cardiotonic steroid. Oleandrigenin shows Na ⁺/K ⁺-ATP-ase inhibiting and cytotoxic activities .

HY-N0239

Bulleyaconitine A	Alkaloids Structural Classification Other Alkaloids Ranunculaceae Source classification Aconitum carmichaeli Debx. Plants	Sodium Channel
Bulleyaconitine A is an analgesic and antiinflammatory drug isolated from Aconitum plants; has several potential targets, including voltage-gated Na+ channels.

HY-N11415

Aurachin SS	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics	Antibiotic Bacterial
Aurachin SS is a nature product that could be isolated from Streptomyces sp. NA04227. Aurachin SS is an antibiotic and has antibacterial activity .

HY-B1654A

Flavin adenine dinucleotide disodium salt 1 Publications Verification FAD disodium salt; FAD-Na2	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, more specifically a prosthetic group of a protein, involved in several important enzymatic reactions in metabolism.

HY-114252R

Strophanthidin (Standard)	Structural Classification Source classification Plants Brassicaceae Steroids Erysimum cheiranthoides Linn.	Na+/K+ ATPase
Strophanthidin (Standard) is the analytical standard of Strophanthidin. This product is intended for research and analytical applications. Strophanthidin is a naturally available cardiac glycoside . Strophanthidin 0.1 and 1 nmol/L increases and 1~100 μmol/L inhibits the Na+/K+-ATPase activities, but Strophanthidin 10 and 100 nmol/L does not affect Na+/K+-ATPase activities in cardiac sarcolemmal . Strophanthidin increases both diastolic and systolic intracellular Ca2+ concentration .

HY-N0736R

Coptisine chloride (Standard)	Alkaloids Structural Classification Coptis chinensis Franch. Ranunculaceae Source classification Plants Isoquinoline Alkaloids	Indoleamine 2,3-Dioxygenase (IDO) Bacterial Influenza Virus
Coptisine (chloride) (Standard) is the analytical standard of Coptisine (chloride). This product is intended for research and analytical applications. Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC₅₀ value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC₅₀ of 104.6 μg/mL and can be used for influenza A (H1N1) infection.

HY-N0143

Phlorizin 5+ Cited Publications Floridzin	Structural Classification Flavonoids Classification of Application Fields Malus pumila Mill. Source classification Rosaceae Phenols Polyphenols Metabolic Disease Plants Dihydrochalcones Disease Research Fields	SGLT Na+/K+ ATPase
Phlorizin (Floridzin) is a non-selective SGLT inhibitor with K_is of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na ⁺/K ⁺-ATPase inhibitor.

HY-N2070

Acevaltrate 2 Publications Verification	Structural Classification Iridoids Terpenoids Source classification Valeriana officinalis Linn. Plants Valerianaceae	Na+/K+ ATPase
Acevaltrate inhibits the Na ⁺/K ⁺-ATPase activity in the rat kidney and brain hemispheres with IC₅₀s of 22.8 μM and 42.3 μM, respectively .

HY-13719R

Oleandrin (Standard)	Apocynaceae Structural Classification Source classification Nerium indicum Mill. Plants Steroids	Na+/K+ ATPase
Oleandrin (Standard) is the analytical standard of Oleandrin. This product is intended for research and analytical applications. Oleandrin (PBI-05204) inhibits the Na+, K+-ATPase activity with an IC50 of 620 nM.

HY-128700

Nicotinic acid mononucleotide	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Others
Nicotinic acid mononucleotide (NAMN) is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD ⁺. Nicotinate mononucleotide is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase .

HY-W754708

Ouabagenin	Structural Classification Microorganisms Cardiacglycosides Source classification Endogenous metabolite Steroids	LXR Na+/K+ ATPase
Ouabagenin is a naturally occurring LXR ligand with LXR selective agonist activity. Ouabagenin acts as an EC 3.6.3.9 (Na(+)/K(+)- transport ATPase) inhibitor .

HY-N1217

Stauntosaponin A Stauntoside C	Apocynaceae Structural Classification Source classification Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Steroids	Na+/K+ ATPase
Stauntosaponin A, a steroid glycoside, is a potent inhibitor of Na(+)/K(+)-ATPase with an IC₅₀ value of 21 nM. Stauntosaponin A can be isolated from Carnation and has potential anti-cancer research value .

HY-N6868

Dimethyl lithospermate B dmLSB	Cardiovascular Disease Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields	Sodium Channel
Dimethyl lithospermate B (dmLSB) is a selective Na ⁺ channel agonist. Dimethyl lithospermate B slows inactivation of sodium current (INa), leading to increased inward current during the early phases of the action potential (AP) .

HY-136933

Gitoxin	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Source classification Scrophulariaceae Plants Disease Research Fields Steroids	Na+/K+ ATPase
Gitoxin, a Na ⁺/K ⁺-ATPase inhibitor, usually appears as a result of metabolic degradation of Digitoxin, is just the hydroxyl (ZOH) group close to the C-17β position, which changes the pharmacokinetics and pharmacodynamics of these substances considerably .

HY-N10097

Chamigrenol	Structural Classification Cupressaceae Terpenoids Sesquiterpenes Source classification Plants Thujopsis dolabrata (Thunberg ex L. f.) Sieb. et Zucc.	Na+/K+ ATPase Bacterial
Chamigrenol is a Na ⁺/K ⁺-ATPase inhibitor with an IC₅₀ value of 15.9 μg/mL. Chamigrenol shows strong inhibitory activities against Gram-positive and Gram-negative bacteria except Escherichia coli, with MIC values of 50 µg/mL .

HY-N0143R

Phlorizin (Standard)	Structural Classification Flavonoids Malus pumila Mill. Source classification Rosaceae Phenols Polyphenols Plants Dihydrochalcones	SGLT Na+/K+ ATPase
Phlorizin (Standard) is the analytical standard of Phlorizin. This product is intended for research and analytical applications. Phlorizin (Floridzin) is a non-selective SGLT inhibitor with Kis of 300 and 39 nM for hSGLT1 and hSGLT2, respectively. Phlorizin is also a Na+/K+-ATPase inhibitor.

HY-N0039

Ginsenoside Rb1 5+ Cited Publications Gypenoside III	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV
Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-B0964

Riboflavin phosphate sodium Riboflavine phosphate sodium; Riboflavin 5'-phosphate sodium; Riboflavine 5'-phosphate sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Riboflavin phosphate sodium (FMN-Na) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate sodium can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism . Riboflavine phosphate sodium is a very effective NAD ⁺-recycling agent .

HY-N10156

1,3,5-Trihydroxy-4-prenylxanthone	Flavonoids Leguminosae Source classification Plants Other Flavonoids Erythrina variegata Linn.	Na+/H+ Exchanger (NHE) Phosphodiesterase (PDE) NO Synthase
1,3,5-Trihydroxy-4-prenylxanthone is a Na ⁺/H ⁺ exchange system (Na+/H+ Exchanger (NHE)) inhibitor with a minimum inhibitory concentration of 10 μg/mL . 1,3,5-Trihydroxy-4-prenylxanthone is a phosphodiesterase type 5 (PDE5) (Phosphodiesterase (PDE)) inhibitor with an IC₅₀ value of 3.0 μM . 1,3,5-Trihydroxy-4-prenylxanthone inhibits Lipopolysaccharide (LPS) (Lipopolysaccharides (HY-D1056))-induced NO production in RAW264.7 macrophages, and has anti-inflammatory activities .

HY-N10239

Aquastatin A	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Metabolic Disease Disease Research Fields	Others
Aquastatin A is an inhibitor of mammalian adenosine triphosphatases. Aquastatin A is isolated from a fungus identified as Fusarium aquaeductuum. Aquastatin A inhibits Na+/K(+)-ATPase with an IC₅₀ value of 7.1 μM, and H+/K(+)-ATPase with an apparent IC₅₀ value of 6.2 μM .

HY-N9149

Cryptanoside A	Apocynaceae Triterpenes Structural Classification Terpenoids Source classification Plants Cryptolepis buchananii Roem. et Schult.	Na+/K+ ATPase Akt NF-κB
Cryptanoside A, a cardiac glycoside epoxide, can be isolated from the stems of Cryptolepis dubia. Cryptanoside A has potent cytotoxicity against cancer cells. Cryptanoside A also inhibits *Na+/K+-ATPase* activity. Cryptanoside A increases the expression of Akt and the p65 subunit of NF-κB .

HY-N0877

Bufalin 5+ Cited Publications	Structural Classification Animals Classification of Application Fields Source classification Disease Research Fields Steroids Cancer	Na+/K+ ATPase
Bufalin is an active component isolated from Chan Su, acts as a potent Na ⁺/K ⁺-ATPase inhibitor, binds to the subunit α1, α2 and α3, with K_d of 42.5, 45 and 40 nM, respectively . Anti-cancer activity .

HY-A0154

Deslanoside DeacetyllaNatoside C; DesacetyllaNatoside C	Digitalis purpurea Linn. Cardiovascular Disease Structural Classification Classification of Application Fields Cardiacglycosides Source classification Scrophulariaceae Plants Disease Research Fields Steroids	Na+/K+ ATPase Drug Metabolite
Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the *Na-K-ATPase* membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-N0150

Monensin sodium 15+ Cited Publications Monensin A sodium	Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics Plant agriculture research Cancer	Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt
Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-N4302

Monensin Monensin A	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt
Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na ⁺/H ⁺ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-N9404

6-Benzoylheteratisine	Alkaloids Piperidine Alkaloids Structural Classification Source classification Ranunculaceae Aconitum carmichaeli Debx. Plants	Sodium Channel
6-Benzoylheteratisine is an Aconitum alkaloid with potential neuroprotective activity. 6-Benzoylheteratisine can antagonize tetrodotoxin, inhibit the increase of [Na ⁺]i, [Ca ²⁺]i and glutamate release, and block sodium channels. 6-Benzoylheteratisine has an inhibitory effect on the neuronal activity underlying epileptiform burst discharge .

HY-B0964R

Riboflavin phosphate sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
Riboflavin phosphate (sodium) (Standard) is the analytical standard of Riboflavin phosphate (sodium). This product is intended for research and analytical applications. Riboflavin phosphate sodium (FMN-Na) is a derivative of Riboflavin (vitamin B2) which is an essential nutrient for animals. Riboflavin phosphate sodium can be used for the research of progressive keratoconus, corneal ectasia and irregular astigmatism . Riboflavine phosphate sodium is a very effective NAD+-recycling agent .

HY-N1381

Periplocin 3 Publications Verification	Structural Classification Classification of Application Fields Source classification Asclepiadaceae Plants Periploca sepium Bunge Inflammation/Immunology Disease Research Fields Steroids	Apoptosis
Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .

HY-N8441

Neriifolin 17β-Neriifolin	Apocynaceae Structural Classification Classification of Application Fields Cardiacglycosides Cerbera manghas Linn. Source classification Plants Inflammation/Immunology Disease Research Fields Steroids	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-N0039R

Ginsenoside Rb1 (Standard) Gypenoside III (Standard)	Panax ginseng C. A. Meyer Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae Cancer	Na+/K+ ATPase IRAK NF-κB Autophagy Mitophagy HSV
Ginsenoside Rb1 (Standard) is the analytical standard of Ginsenoside Rb1. This product is intended for research and analytical applications. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na ⁺, K ⁺-ATPase activity with an IC₅₀ of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65 .

HY-N13080

3-Oxo-bufalin	Structural Classification Microorganisms Source classification Steroids	Others
3-Oxo-bufalin is an active compound that can be isolated from cultured toad liver tissue. 3-Oxo-bufalin can be produced through a metabolic pathway, and it is a metabolite of Bufalin (HY-N0877) catalyzed by the stereoselective 3β-dehydrogenase. Bufalin is a Na+/K+-ATPase inhibitor and has anti-tumor activity .

HY-N0877R

Bufalin (Standard)	Structural Classification Animals Source classification Steroids	Na+/K+ ATPase
Bufalin (Standard) is the analytical standard of Bufalin. This product is intended for research and analytical applications. Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively . Anti-cancer activity .

HY-N7922

Urolithin M5 Decarboxyellagic acid	Structural Classification Canarium album (Lour.) Rauesch. Source classification Phenols Polyphenols Plants Burseraceae	Influenza Virus
Urolithin M5 is a neuraminidase inhibitor that can be isolated from Ganlanye. Urolithin M5 has antiviral activity in vitro and in vivo by inhibiting the activity of viral NA. Urolithin M5 can increase the survival rate and improve pulmonary edema in pr8-infected mouse models. Urolithin M5 can be used in anti-influenza research .

HY-A0154R

Deslanoside (Standard)	Digitalis purpurea Linn. Structural Classification Cardiacglycosides Source classification Scrophulariaceae Plants Steroids	Na+/K+ ATPase Drug Metabolite
Deslanoside (Standard) is the analytical standard of Deslanoside. This product is intended for research and analytical applications. Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Deslanoside inhibits the *Na-K-ATPase* membrane pump, resulting in an increase in intracellular sodium and calcium concentrations .

HY-13295

Vinpocetine 5+ Cited Publications Ethyl apovincamiNate	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Apocynaceae Alkaloids Piperidine Alkaloids Disease Research Fields Cancer	Sodium Channel IKK Phosphodiesterase (PDE)
Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na ⁺ channels. The IC₅₀ value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders .

HY-N0150R

Monensin sodium (Standard)	Structural Classification Microorganisms Antibiotics Source classification Antibacterial Disease Research Other Antibiotics Plant agriculture research	Bacterial Antibiotic Na+/H+ Exchanger (NHE) Parasite Apoptosis Fungal Wnt
Monensin (sodium) (Standard) is the analytical standard of Monensin (sodium). This product is intended for research and analytical applications. Monensin (Monensin A) sodium, an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin sodium is a potent Wnt signaling inhibitor. Monensin sodium causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects .

HY-N0603

20(S)-Ginsenoside Rg3 4 Publications Verification 20(S)-PropaNaxadiol; S-ginsenoside Rg3	Panax ginseng C. A. Meyer Triterpenes Structural Classification Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Endogenous metabolite Inflammation/Immunology Disease Research Fields Araliaceae	Sodium Channel Potassium Channel NF-κB COX Amyloid-β Endogenous Metabolite
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na ⁺ and hKv1.4 channel with IC₅₀s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

HY-B1671

(+)-Kavain	Structural Classification Source classification Other Phenylpropanoids Piper methysticum G.Forst. Piperaceae Phenylpropanoids Plants	GABA Receptor Sodium Channel Calcium Channel
(+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na ⁺ and Ca ²⁺ channels . (+)-Kavain is shown to bind at the α4β2δ GABA_A receptor and potentiate GABA efficacy . (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied .

HY-112661

PC-766B Antibiotic PC-766B	Infection Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Fields Cancer	Antibiotic Bacterial Fungal
PC-766B is a macrolide antibiotic. PC-766B is active against Gram-positive bacteria, and some fungi and yeasts, but inactive against Gram-negative bacteria. PC-766B shows antitumor activity against murine tumor cells. PC-766B has weak inhibitory activity against Na ⁺, K ⁺-ATPase .

HY-125337

SC4453	Triterpenes Structural Classification Animals Terpenoids Source classification	Na+/K+ ATPase
SC4453 is a digoxin analogue in which the lactone ring at C17β is replaced by a pyrazine ring. SC4453 is slightly inferior to digoxin in inhibiting (Na+ + K+)-ATPase, but shows similar sensitivity to potassium ions. The differences in the sensitivity of SC4453 to heart and brain tissue from different species are mainly due to differences in its dissociation rate from the receptor. These observations confirm the high sensitivity of the human heart to cardiac glycosides.

Cat. No.	Product Name	Chemical Structure

HY-B1039AS

Ambroxol-d5 hydrochloride

Ambroxol-d₅ (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

HY-103332S

N-Arachidonylglycine-d8

N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine . N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC₅₀ = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC₅₀ = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .

HY-N1446S5

Oleic acid-d9
Oleic acid-d₉ is deuterium labeled Oleic acid. Oleic acid is an abundant monounsaturated fatty acid. Oleic acid is a Na+/K+ ATPase activator[1][2].

HY-B0575S

Triamterene-d5
Triamterene-d₅ is deuterium labeled Triamterene, which can block epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic.

HY-N1446S

Oleic acid-13C
Oleic acid- ¹³C is the ¹³C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-Y0258S1

Benzocaine-(ethyl-d5)
Benzocaine-(ethyl-d₅) is the deuterium labeled Benzocaine. Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.

HY-N1446S3

Oleic acid-d17
Oleic acid-d₁₇ is the deuterium labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-N1446S2

Oleic acid-13C18
Oleic acid- ¹³C₁₈ is the ¹³C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-W015912S

2-Acetylfuran-d3

2-Acetylfuran-d₃ is deuterated labeled Citreoviridin (HY-N6745). Citreoviridin, a toxin from Penicillium citreoviride NRRL 2579, inhibits brain synaptosomal Na ⁺/K ⁺-ATPase whereas in microsomes, both Na ⁺/K ⁺-ATPase and Mg ²⁺-ATPase activities are significantly stimulated in a dose-dependent manner . Citreoviridin inhibits cell proliferation and enhances apoptosis of human umbilical vein endothelial cells .

HY-B0137AS

Prilocaine-d7 hydrochloride
Prilocaine-d₇ (hydrochloride) is deuterium labeled Prilocaine (hydrochloride). Prilocaine hydrochloride, an amino amide, is a Na, K-ATPase inhibitor. Prilocaine has neurotoxic effects[1][2].

HY-N1446S1

Oleic acid-d2 1 Publications Verification
Oleic acid-d₂) is the deuterium labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-N1446S4

Oleic acid-13C-1
Oleic acid- ¹³C-1 is the ¹³C labeled Oleic acid. Oleic acid (9-cis-Octadecenoic acid) is an abundant monounsaturated fatty acid[1]. Oleic acid is a Na+/K+ ATPase activator[2].

HY-17468S

Bumetanide-d5
Bumetanide-d₅ is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].

HY-B0211S

Riluzole-13C,15N2
Riluzole- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Riluzole[1]. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].

HY-B0448S1

Phenytoin-15n2,13c
Phenytoin- ¹⁵N₂, ¹³C is the ¹³C and ¹⁵N labeled Phenytoin[1]. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice[2][3].

HY-B0358AS

Flunarizine-d8 dihydrochloride
Flunarizine-d₈ dihydrochloride is deuterated labeled Flunarizine dihydrochloride (HY-B0358A). Flunarizine dihydrochloride is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-B0495S4

Lamotrigine-13C3
Lamotrigine- ¹³C₃ is the ¹³C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

HY-B0495S5

Lamotrigine-d3
Lamotrigine-d3 is the deuterium labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].

HY-B0495S1

Lamotrigine-13C,d3
Lamotrigine- ¹³C,d₃ is the ¹³C- and deuterium labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

HY-B0495S

Lamotrigine-13C3,d3
Lamotrigine- ¹³C₃,d₃ is the ¹³C-labeled Lamotrigine. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[1][2].

HY-B0495S3

Lamotrigine-13C2,15N
Lamotrigine-13C2,15N is the 13C and 15N labeled Lamotrigine[1]. Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al[2][3].

HY-13295S

Vinpocetine-d5

Vinpocetine-d₅ is the deuterium labeled Vinpocetine. Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].

HY-B0495S6

Lamotrigine-13C2,15N2,d3

Lamotrigine- ¹³C₂, ¹⁵N₂,d₃ is ¹⁵N and deuterated labeled Lamotrigine (HY-B0495). Lamotrigine (BW430C) is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine selectively blocks voltage-gated Na ⁺ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine can be used for the research of epilepsy, focal seizure, et al .

HY-100490S

Rilmenidine-d4

Rilmenidine-d₄ is the deuterium labeled Rilmenidine. Rilmenidine, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine is an alpha 2-adrenoceptor agonist. Rilmenidine induces autophagy. Rilmenidine acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells[1][2][3].

HY-115435S

1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine-d54 sodium
1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine-d₅₄ (sodium) is deuterium labeled 1,2-Dimyristoyl-sn-glycero-3-phospho-L-serine.

HY-B0135S

Furosemide-d5

Furosemide-d₅ is the deuterium labeled Furosemide. Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2[1]. Furosemide is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors. Furosemide acts as a loop diuretic and used for the study of congestive heart failure, hypertension and edema[2].

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