Topoisomerase

Topoisomerase Isoform Specific Products:

Topoisomerase Related Products (558)
Antibodies (4)
Topoisomerase Isoform Comparison

By Effects:	Controls (3) Inhibitors (533) Agonists (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-13566A

Belotecan hydrochloride	Inhibitor	99.88%
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.

HY-13630

Etoposide phosphate	Inhibitor
Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.

HY-153179

Mal-Gly-PAB-Exatecan-D-glucuronic acid	Inhibitor	99.82%
Mal-Gly-PAB-Exatecan-D-glucuronic acid can be used for Antibody-Drug Conjugates (ADCs) synthesis. Mal-Gly-PAB-Exatecan-D-glucuronic acid can be used for research of tumor research and diagnosis.

HY-147270

MC-VA-PAB-Exatecan	Inhibitor	99.58%
MC-VA-PAB-Exatecan is a agent-linker conjugate for ADC. MC-VA-PAB-Exatecan contains the ADC linker (peptide MC-VA-PAB) and a DNA topoisomerase I inhibitor Exatecan (HY-13631). MC-VA-PAB-Exatecan synthesized ADC shows good antitumor activity.

HY-16261

Aldoxorubicin	Inhibitor
Aldoxorubicin (INNO-206) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.

HY-145399

AZ14170133	Inhibitor	98.95%
Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan is a Drug-Linker Conjugates for ADC, which comprises a topoisomerase inhibitor and a linker for ligand unit connecting. Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan can be used to synthesis antibody-drug conjugate (ADC).

HY-N2306

Aclacinomycin A	Inhibitor	99.30%
Aclacinomycin A (Aclarubicin) is an orally active and potent anthracycline antitumor antibiotic. Aclacinomycin A is an inhibitor of topoisomerase I and II. Aclacinomycin A inhibits synthesis of nucleic acid, especially RNA. Aclacinomycin A might inhibit the 26S protease complex as well as the ubiquitin-ATP-dependent proteolysis.

HY-122575

Aurintricarboxylic acid	Inhibitor
Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC₅₀s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC₅₀ of 0.6 μM. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC₅₀ of 0.47 µM.

HY-156376

Cu(II)-Elesclomol	Inhibitor	99.99%
Cu(II)-Elesclomol is a Cu²⁺ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity.

HY-15142R

Doxorubicin (hydrochloride) (Standard)	Inhibitor
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.

HY-13562A

Banoxantrone dihydrochloride	Inhibitor	99.46%
Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-147271

Mal-PEG8-Val-Ala-PAB-Exatecan	Inhibitor	99.48%
Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b) is an antibody-drug conjugate linker (ADC linker) that binds to Nectin-4 polypeptides conjugated to chemotherapeutic agents. Mal-PEG8-Val-Ala-PAB-Exatecan can be used for cancer research.

HY-103399

Trovafloxacin mesylate	Inhibitor	99.76%
Trovafloxacin mesylate is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin mesylate blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin mesylate is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC₅₀ of 4 μM for PANX1 inward current. Trovafloxacin mesylate does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin mesylate leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1.

HY-B0398

Nalidixic acid	Inhibitor	99.97%
Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.

HY-44369

Exatecan Intermediate 6	Inhibitor	98.92%
Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).

HY-N2331

Proscillaridin A	Inhibitor	99.74%
Proscillaridin A is a potent poison of topoisomerase I/II activity with IC₅₀ values of 30 nM and 100 nM, respectively.

HY-148820

Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT	Inhibitor	98.65%
Br-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (Formula V) is a agent-linker conjugate that composed of a potent topoisomerase I inhibitor and a linker to make antibody agent conjugate (ADC).

HY-A0170

Trovafloxacin	Inhibitor	98.99%
Trovafloxacin is a broad-spectrum quinolone antibiotic with potent activity against Gram-positive, Gram-negative and anaerobic organisms. Trovafloxacin blocks the DNA gyrase and topoisomerase IV activity. Trovafloxacin is also a potent, selective and orally active pannexin 1 channel (PANX1) inhibitor with an IC₅₀ of 4 μM for PANX1 inward current. Trovafloxacin does not inhibit connexin 43 gap junction or PANX2. Trovafloxacin leads to dysregulated fragmentation of apoptotic cells by inhibiting PANX1.

HY-17577

Berberine chloride hydrate	Inhibitor	99.82%
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid that acts as an antibiotic. Berberine chloride hydrate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Antineoplastic properties.

HY-B0330A

Levofloxacin hydrate	Inhibitor	99.93%
Levofloxacin hydrate (Levofloxacin hemihydrate) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin hydrate inhibits the DNA gyrase and topoisomerase IV. Levofloxacin hydrate can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin hydrate shows anti-orthopoxvirus activity.

Doxorubicin hydrochloride		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM	99.90%
Etoposide			Topoisomerase II	99.94%
Dxd		Topoisomerase I, IC₅₀: 0.31 μM		99.30%
SN-38		Topoisomerase I		99.89%
Camptothecin		Topoisomerase I, IC₅₀: 679 nM		99.86%
Irinotecan		Topoisomerase I		99.97%
Topotecan hydrochloride		Topoisomerase I		99.89%
Daunorubicin hydrochloride			Topoisomerase II	99.67%
Mitoxantrone			Topoisomerase II	99.58%
Epirubicin hydrochloride	Topoisomerase			99.16%
Irinotecan hydrochloride		Topoisomerase I		99.89%
Datopotamab deruxtecan		Topoisomerase I		99.54%
Levofloxacin	TOPO IV			99.92%
Idarubicin hydrochloride			Topoisomerase II	99.94%
Betulinic acid		Topoisomerase I, IC₅₀: 5 μM		98.43%
Mitoxantrone dihydrochloride			Topoisomerase II	99.55%
β-Lapachone		Topoisomerase I		99.99%
Dxd-d₅		Topoisomerase I, IC₅₀: 0.31 μM		98.84%
Teniposide			Topoisomerase II	99.00%
Pirarubicin			Topoisomerase II	99.61%
Irinotecan hydrochloride trihydrate		Topoisomerase I		99.89%
PNU-159682		Topoisomerase I		98.25%
Belotecan hydrochloride		Top1		99.88%
Etoposide phosphate			Topoisomerase II
Aldoxorubicin			Topoisomerase II
Aclacinomycin A		Topoisomerase I	Topoisomerase II	99.30%
Aurintricarboxylic acid			Topoisomerase II
Banoxantrone dihydrochloride			Topoisomerase II	99.46%
Nalidixic acid	Topoisomerase			99.97%
Proscillaridin A		Topoisomerase I, IC₅₀: 30 nM	Topoisomerase II, IC₅₀: 100 nM	99.74%
Levofloxacin hydrate	TOPO IV			99.93%
Pirarubicin Hydrochloride			Topoisomerase II	98.56%
(S)-10-Hydroxycamptothecin		Topoisomerase I		99.38%
Ellipticine			Topoisomerase II	99.56%
Bisantrene			Topoisomerase II	98.08%
Pixantrone			Topoisomerase II	98.75%
Amsacrine			Topoisomerase II	99.95%
Gatifloxacin			Topoisomerase II, IC₅₀: 36.7 μM	99.69%
PluriSIn #2			topoisomerase II alpha	≥98.0%
MC-GGFG-AM-(10Me-11F-Camptothecin)		Topoisomerase I		98.06%
Hycanthone		Topoisomerase I	Topoisomerase II	99.97%
Ellipticine hydrochloride			Topoisomerase II	99.34%
Amonafide			Topoisomerase II	99.92%
Coralyne chloride		Topoisomerase I		98.30%
Voreloxin Hydrochloride			Topoisomerase II	99.58%
Amsacrine hydrochloride			Topoisomerase II	99.98%
TAS-103 dihydrochloride		Topoisomerase I	Topoisomerase II	98.87%
MC-DOXHZN hydrochloride			Topoisomerase II	98.04%
Chloroquinoxaline sulfonamide			topoisomerase II alpha topoisomerase II beta	99.06%
Indotecan		Topoisomerase I		≥98.0%
Amrubicin			Topoisomerase II	≥98.0%
Genz-644282		Topoisomerase I		99.53%
9-Aminocamptothecin		Topoisomerase I		98.89%
(±)-10-Hydroxycamptothecin		Topoisomerase I		99.57%
Nalidixic acid sodium salt	Topoisomerase			99.83%
Intoplicine		Topoisomerase I	Topoisomerase II	98.36%
Gatifloxacin hydrochloride			Topoisomerase II, : 36.7 μM	99.94%
Daun02	Topoisomerase			98.72%
Flumequine			Topoisomerase II, IC₅₀: 15 μM
Gimatecan		Topoisomerase I		99.28%
(±)-Evodiamine		Top1		99.74%
Lurtotecan		Topoisomerase I		98.01%
Isodiospyrin		Topoisomerase I		99.77%
Indimitecan		Top1		98.30%
Karenitecin		Topoisomerase I		98.02%
LMP744 hydrochloride		Top1		99.70%
Groenlandicine		Topoisomerase I		99.87%
ARN-21934			topoisomerase II alpha topoisomerase II beta	98.08%
Levofloxacin hydrochloride	TOPO IV			≥98.0%
Podocarpusflavone A		Topoisomerase I, IC₅₀: 119.425 μM		99.62%
LMP517		Topoisomerase I	Topoisomerase II	99.58%
Garenoxacin Mesylate hydrate	TOPO IV, IC₅₀: 1.5-2.5 μg/mL			99.78%
LMP744		Top1		98.85%
Aclacinomycin A hydrochloride		Topoisomerase I	Topoisomerase II
Namitecan		Topoisomerase I		99.25%
Elomotecan hydrochloride		Topoisomerase I	Topoisomerase II
SW044248		Topoisomerase I		99.60%
Epirubicin	Topoisomerase			98.45%
Topoisomerase I inhibitor 8		Topoisomerase I
Topoisomerase II inhibitor 20 TFA			Topoisomerase II, IC₅₀: 0.98 μM
9-Hydroxyellipticine hydrochloride			Topoisomerase II	≥99.0%
Topotecan		Topoisomerase I
Doxorubicin		Topoisomerase I, IC₅₀: 0.8 μM	Topoisomerase II, IC₅₀: 2.67 μM
Daunorubicin			Topoisomerase II
Topoisomerase II inhibitor 20			Topoisomerase II, IC₅₀: 0.98 μM	98.44%
CH-0793076		Topoisomerase I, IC₅₀: 2.3 μM
AQ4			Topoisomerase II
BNS-22			topoisomerase II alpha, IC₅₀: 2.8 μM (in human) topoisomerase II beta, IC₅₀: 0.42 μM (in human)	99%
Seconeolitsine		Topoisomerase I, IC₅₀: 17 μM
Edotecarin		Topoisomerase I, IC₅₀: 50 nM		98.39%
CH-0793076 TFA		Topoisomerase I, IC₅₀: 2.3 μM		98.71%
Zabofloxacin		Topoisomerase I	Topoisomerase II	98.02%
Zabofloxacin hydrochloride		Topoisomerase I	Topoisomerase II	99.54%
Amrubicin hydrochloride			Topoisomerase II
Pixantrone free base			Topoisomerase II
Voreloxin			Topoisomerase II	99.26%
TAS-103		Topoisomerase I	Topoisomerase II
MC-DOXHZN			Topoisomerase II
Topotecan hydrochloride hydrate		Topoisomerase I
Etoposide phosphate disodium			Topoisomerase II
Idarubicin			Topoisomerase II
Gatifloxacin sesquihydrate			Topoisomerase II, IC₅₀: 36.7 μM
Rebeccamycin		Topoisomerase I
Mitoxantrone diacetate			Topoisomerase II
CBX-12		Topoisomerase I
Daunorubicin citrate			Topoisomerase II
Antitumor agent-63		Top1
Silatecan		Topoisomerase I
Topoisomerase II inhibitor 9			Topoisomerase II, IC₅₀: 0.97 μM
Topo I/COX-2-IN-1		Topoisomerase I, IC₅₀: 4.42 μM
Bimolane			Topoisomerase II
T-2513 hydrochloride		Topoisomerase I
TOPOI/PARP-1-IN-2		Top1, IC₅₀: 46.2 nM
Topo I/COX-2-IN-2		Topoisomerase I, IC₅₀: 0.90 μM
Topoisomerase II inhibitor 11			Topoisomerase II, IC₅₀: 2.89 μM
CS1			topoisomerase II alpha
T-2513		Topoisomerase I
Razoxane			Topoisomerase II	99.16%
Topoisomerase IIα-IN-3			topoisomerase II alpha
Heliquinomycin		Topoisomerase I	Topoisomerase II
Topoisomerase II/EGFR-IN-1			Topoisomerase II
VcMMAE-Deruxtecan		Topoisomerase I
Anticancer agent 75			Topoisomerase II
CP-67804			Topoisomerase II
DTS-108		Top1
Pixantrone hydrochloride			Topoisomerase II
Topoisomerase II inhibitor 4			Topoisomerase II
Topoisomerase IIα-IN-6			topoisomerase II alpha, IC₅₀: 0.67 μM
Topoisomerase IIα-IN-2			topoisomerase II alpha topoisomerase II beta
Topoisomerase IIα-IN-4			topoisomerase II alpha, IC₅₀: 3.8 μM topoisomerase II beta, IC₅₀: 10.1 μM
ZLHQ-5f		Top1
3-Fluoro-evodiamine glucose		Topoisomerase I	Topoisomerase II
Topo I-IN-1		Topoisomerase I
Topoisomerase I/II inhibitor 6		Topoisomerase I, IC₅₀: 4.77 μM	Topoisomerase II, IC₅₀: 15 μM
EGFR-IN-116			Topoisomerase II, IC₅₀: 19.74 μM
Top/HDAC-IN-2		Top1	Topoisomerase II
Anti-MRSA agent 7	TOPO IV, IC₅₀: 0.059 μM (E. coli ) TOPO IV, IC₅₀: 0.341 μM (S. aureus)
Topoisomerase II inhibitor 18			Topoisomerase II, IC₅₀: 7.5 μM
Topoisomerase I inhibitor 17		Top1
Elomotecan		Topoisomerase I	Topoisomerase II
Topoisomerase II inhibitor 5			Topoisomerase II
LE01		Topoisomerase I
HSP90-IN-13	Topoisomerase-2, IC₅₀: 25.85 nM
Topoisomerase I inhibitor 2		Topoisomerase I, IC₅₀: 0.58 μM
iNOS/TopoI-IN-1		Topoisomerase I, Ki: 2.72 μM
Topoisomerase II inhibitor 10			Topoisomerase II, IC₅₀: 7.45 μM
Salvicine			Topoisomerase II, IC₅₀: 3 μM
Topoisomerase IV inhibitor 1	TOPO IV, IC₅₀: 0.23 μM
Topoisomerase II inhibitor 13			Topoisomerase II	99.26%
EGFR-IN-57			topoisomerase II beta, IC₅₀: 0.13 μM
Topoisomerase IIα-IN-1			topoisomerase II alpha topoisomerase II beta
Huanglongmycin N		Topoisomerase I, EC₅₀: 14 μM
Topoisomerase IIα-IN-8			topoisomerase II alpha
Tilatamig samrotecan		Topoisomerase I
Deruxtecan-Eribulin		Topoisomerase I
CP-67015			Topoisomerase II
Tapcin		Topoisomerase I, IC₅₀: 203 nM	Topoisomerase II, IC₅₀: 71 nM
Topoisomerase I inhibitor 12		Topoisomerase I
Topoisomerase II inhibitor 17			Topoisomerase II, IC₅₀: 0.23 μM
Topoisomerase I/II inhibitor 2		Topoisomerase I	Topoisomerase II
Topo I/II-IN-2		Topoisomerase I	Topoisomerase II
Saintopin		Topoisomerase I	Topoisomerase II
Intoplicine dimesylate		Topoisomerase I	Topoisomerase II	98.28%
Topoisomerase IV inhibitor 2	TOPO IV, IC₅₀: 0.35 μM
Topoisomerase II inhibitor 7			topoisomerase II alpha, IC₅₀: 3.19 μM
Topoisomerase I/II inhibitor 7		Topoisomerase I	Topoisomerase II
Topoisomerase IIα-IN-7			topoisomerase II alpha, IC₅₀: 7.7 μM
Niranthin	Topoisomerase
Epolactaene			Topoisomerase II, IC₅₀: 10 μM
Topoisomerase I inhibitor 3		Topoisomerase I
Topoisomerase II inhibitor 19			Topoisomerase II, IC₅₀: 0.34 μM
Corydamine		Topoisomerase I	Topoisomerase II
TP0480066			Topoisomerase II
AZD5099			Topoisomerase II
Topoisomerase I inhibitor 16		Topoisomerase I
TP3011		Topoisomerase I
Topoisomerase II inhibitor 8			Topoisomerase II, IC₅₀: 0.52 μM
Topoisomerase I/II inhibitor 3		Topoisomerase I	Topoisomerase II
Gatifloxacin mesylate			Topoisomerase II, IC₅₀: 36.7 μM
Topoisomerase IIα-IN-5			topoisomerase II alpha
Thaspine acetate		Topoisomerase I	Topoisomerase II
Antibacterial agent 229	TOPO IV, IC₅₀: 10.88 μM
(-)-BO 2367			Topoisomerase II
8-Chloro-ATP tetrasodium			Topoisomerase II
Garenoxacin	TOPO IV, IC₅₀: 1.5-2.5 μg/mL
HU 331			Topoisomerase II
Luotonin F			Topoisomerase II
Topovale		Topoisomerase I
NK 314			topoisomerase II alpha
8-Chloro-ATP			Topoisomerase II

Name
Email *

	Sorry, but the email address you supplied was invalid.

Topoisomerase

Topoisomerase

Topoisomerase Isoform Specific Products:

Topoisomerase Isoform Specific Products:

Topoisomerase Related Products (558)

Antibodies (4)

Topoisomerase Isoform Comparison

Topoisomerase Related Products (558):