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Results for "

proteasome

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Proteasome (126) ADC Antibody (2) Akt (5) Androgen Receptor (3) Antibiotic (1) Apoptosis (57) AUTACs (2) Autophagy (23) Bacterial (9) Bcl-2 Family (5) BCL6 (1) Bcr-Abl (2) Biochemical Assay Reagents (3) Btk (1) c-Fms (1) c-Kit (1) c-Met/HGFR (2) c-Myc (1) Calcium Channel (1) CaMK (1) Caspase (2) CD38 (2) CDK (7) Ceramidase (1) ClpP (1) Deubiquitinase (7) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (4) E3 Ligase Ligand-Linker Conjugates (2) EGFR (4) Endogenous Metabolite (8) Epigenetic Reader Domain (6) Estrogen Receptor/ERR (6) Ferroptosis (7) FGFR (1) FLT3 (3) Fluorescent Dye (1) Fungal (4) Glutaminase (1) Glutathione Peroxidase (1) HDAC (3) Hexokinase (1) Histone Demethylase (1) Histone Methyltransferase (9) HIV (6) HSP (4) IAP (1) IGF-1R (1) IKK (1) Interleukin Related (1) IRAK (1) Isotope-Labeled Compounds (2) JAK (2) Keap1-Nrf2 (4) Ligands for E3 Ligase (5) Ligands for Target Protein for PROTAC (1) Lipoxygenase (1) MAP4K (2) MDM-2/p53 (1) Mitophagy (3) MMP (2) Molecular Glues (9) NAMPT (3) NEKs (1) NF-κB (12) NOD-like Receptor (NLR) (1) Oxidative Phosphorylation (1) p97 (1) Parasite (8) PARP (2) PDGFR (1) PERK (1) Phosphatase (3) Phosphodiesterase (PDE) (1) PIN1 (2) PROTAC Linkers (9) PROTACs (56) RAD51 (2) Raf (2) RAR/RXR (1) Ras (2) Reactive Oxygen Species (3) Ribosomal S6 Kinase (RSK) (1) ROS Kinase (1) SARS-CoV (1) Ser/Thr Kinase (1) Ser/Thr Protease (2) SHP2 (1) Sigma Receptor (1) SNIPERs (6) STAT (5) STING (2) Target Protein Ligand-Linker Conjugates (1) VEGFR (1) WDR5 (1) Wnt (4) YAP (1) β-catenin (9)
By Research Areas:	Cancer (212) Cardiovascular Disease (2) Endocrinology (1) Infection (18) Inflammation/Immunology (43) Metabolic Disease (13) Neurological Disease (17)
Click Chemistry:	PROTAC Synthesis (2) Azide (1) Alkynes (1)

288

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Peptides

Inhibitory Antibodies

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Recombinant Proteins

Isotope-Labeled Compounds

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Click Chemistry

Targets Recommended: Proteasome

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3414A

Proteasome-activating peptide 1 TFA 1 Publications Verification	Proteasome	Neurological Disease
Proteasome-activating peptide 1 TFA is a peptide and a potent proteasome activator. Proteasome-activating peptide 1 TFA increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 TFA prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis .

HY-107412

Proteasome inhibitor IX PS-IX; AM114	Proteasome	Cancer
Proteasome inhibitor IX (PS-IX; AM114) is a Chalcone derivative and a chymotrypsin-like activity of the 20S proteasome inhibitor with an IC₅₀ value of ~1 μM. Proteasome inhibitor IX exhibits HCT116 p53 ^+/+ cells growth inhibitory activity with an IC₅₀ value of 1.49 μM. Proteasome inhibitor IX has potent anticancer activity .

HY-P1258

PSI proteasome Inhibitor 1; Z-Ile-Glu(OtBu)-Ala-Leu-CHO	Proteasome	Infection Cancer
PSI (Proteasome Inhibitor 1) is a potent *proteasome* inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas .

HY-157032

Proteasome-IN-5	Proteasome	Others
Proteasome-IN-5 (compound 5) is a proteasome inhibitor .

HY-144369

Proteasome-IN-4	Proteasome	Cancer
Proteasome-IN-4 is an excellent and non-covalent *proteasome* inhibitor (IC₅₀=8.39 nM). Proteasome-IN-4 has potent antiproliferative activities against RPMI-8226, MM-1S and MV-4-11 cell lines. Proteasome-IN-4 can be used for cancer research .

HY-157035

Proteasome β2c/i-IN-1	Proteasome	Others
Proteasome β2c/i-IN-1 (compound 37) is a subunit-selective human proteasome β2c and β2i inhibitor .

HY-100172

Proteasome-IN-1	Proteasome	Cancer
Proteasome-IN-1 is a *proteasome* inhibitor extracted from patent WO 2013142376 A1.

HY-170363

Proteasome-IN-6	Proteasome Parasite	Infection
Proteasome-IN-6 (Compound J-80) inhibits the β5 catalytic subunit of the Trypanosoma brucei 20S proteasome, inibits T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC₅₀s of 157 nM, 220 nM and 156 nM, respectively. Proteasome-IN-6 exhibits antitrypanosomal activity in mouse model .

HY-P3414

Proteasome-activating peptide 1	Proteasome	Neurological Disease
Proteasome-activating peptide 1 is a peptide, which increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis .

HY-P1258A

PSI TFA proteasome Inhibitor 1 TFA; Z-Ile-Glu(OtBu)-Ala-Leu-CHO TFA	Proteasome	Infection Cancer
PSI (TFA) is a potent *proteasome* inhibitor. PSI (TFA) inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI (TFA) can be used for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas .

HY-134961

Z-Ala-Arg-Arg-AMC Fluorogenic proteasome Substrate; Z-ARR-AMC	Proteasome	Others
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .

HY-150591

*20S Proteasome-IN-3*	Proteasome	Cancer
20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC₅₀=1.64 μM) . 20S Proteasome-IN-3 shows anti-tumor proliferation activity .

HY-151195

*20S Proteasome-IN-4*	Proteasome Parasite	Infection
20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC₅₀ of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT) .

HY-150590

*20S Proteasome-IN-2*	Proteasome	Cancer
20S Proteasome-IN-2 is a human 20S proteasome inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC₅₀ of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in vivo, and arrests cell cycle at G2/M .

HY-169134

*PROTAC 20S proteasome* subunit β5 degrader 1**	PROTACs Apoptosis	Cancer
PROTAC 20S proteasome subunit β5 degrader 1 (compound 12f) is a targeted degrader of PROTAC for 20S proteasome subunit β5, with a DC₅₀ value of 0.11 μM in FaDu cells. PROTAC 20S proteasome subunit β5 degrader 1 disrupts the cell cycle, promotes apoptosis, and inhibits cell proliferation and migration in both FaDu and KM3/BTZ cells. PROTAC 20S proteasome subunit β5 degrader 1 can be used to study the resistance of pharyngeal cancer and multiple myeloma to Bortezomib (HY-10227) (Pink: Target protein ligand (HY-10227); Blue: E3 ligase ligand (HY-103596); Black: Linker (HY-169142)) .

HY-139331

*20S Proteasome-IN-1*	Proteasome	Neurological Disease Inflammation/Immunology Cancer
20S Proteasome-IN-1 is a 26S proteasome inhibitor extracted from patent WO2006128196A2 compound 2. 20S Proteasome-IN-1 has the potential for cancer, immune-related disorders, inflammation, ischemic conditions, neurodegenerative disorders and other diseases research .

HY-157212

*PARP-1/Proteasome-IN-1*	Apoptosis PARP Proteasome	Cancer
PARP-1/Proteasome-IN-1 (compound 42i) is a dual PARP-1 and proteasome inhibitor with significant inhibitory effects on breast cancer. *PARP-1/Proteasome*-IN-1 can downregulate the expression of BRCA1 and RAD51 to inhibit homologous recombination repair function and induce apoptosis .

HY-158150

*20S Proteasome-IN-5*	Proteasome	Cancer
20S Proteasome-IN-5 (Compound 5) is a macrocyclic inhibitor of the 20S Proteasome, with IC₅₀ values of 0.19 and 52.5 μM for ChT-L and PGPH-L activity, respectively .

HY-150602

*20S Proteasome* activator 1**	Proteasome	Neurological Disease
20S Proteasome activator 1 is a potent 20S proteasome activator with EC₂₀₀ values of 0.3 μM, 0.7 μM and 1.8 μM for trypsin-like site, chymotrypsin-like site and caspase-like site. 20S Proteasome activator 1 translates well in a cellular system, preventing the accumulation of the pathogenic A53T mutant of α-synuclein. 20S Proteasome activator 1 can be used for researching neurodegenerative diseases .

HY-P10060

Boc-Val-Gly-Arg-AMC	Biochemical Assay Reagents	Others
Boc-Val-Gly-Arg-AMC is a peptide substrate that can be used to study activity of the proteasome .

HY-P10003

iso-VQA-ACC	Proteasome	Cancer
iso-VQA-ACC is a substrate for constitutive proteasome .

HY-P10003B

iso-VQA-ACC acetate	Proteasome	Others
iso-VQA-ACC acetate is a substrate for constitutive proteasome .

HY-P10003A

iso-VQA-ACC TFA	Proteasome	Others
iso-VQA-ACC TFA is a constitutive proteasome substrate .

HY-135070

Ac-RLR-AMC Ac-Arg-Leu-Arg-AMC	Proteasome	Others
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .

HY-P10317

Suc-YVAD-AMC	Fluorescent Dye	Others
Suc-YVAD-AMC is used to measure the cysteine proteins of the proteasome.Suc-YVAD-AMC releases fluorescent AMC when cleaved by cysteine proteases to assess the enzymatic activity of the proteasome .

HY-169135

*PROTAC 20S proteasome* subunit β5 degrader 2**	PROTACs Proteasome	Cancer
PROTAC 20S proteasome subunit β5 degrader 2 is a PROTAC degrader for *20S proteasome* subunit β5, with a DC₅₀** of 0.16 μM. PROTAC 20S proteasome subunit β5 degrader 2 inhibits the proliferation of cancer cell FaDu with IC₅₀ of 0.23 μM. PROTAC 20S proteasome subunit β5 degrader 2 exhibits antitumor efficacy in mice models . (Pink: Ligand for target protein (HY-10227); Blue: Ligand for E3 ligase (HY-103596); Black: Linker (HY-Y1760))

HY-115391

Boc-LRR-AMC Boc-Leu-Arg-Arg-AMC	Biochemical Assay Reagents	Others
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .

HY-N14927

Phepropeptin A	Proteasome	Inflammation/Immunology
Phepropeptin A, a microbial secondary metabolite, is a *proteasome* inhibitor with an IC₅₀ of 21 μg/mL .

HY-137281

HMB-Val-Ser-Leu-VE	Ser/Thr Protease	Others
HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC₅₀ of 0.033 μM .

HY-N14928

Phepropeptin B	Proteasome	Inflammation/Immunology
Phepropeptin B, a microbial secondary metabolite, is a *proteasome* inhibitor with an IC₅₀ of 11 μg/mL .

HY-135396

(1S,2S)-Bortezomib	Proteasome Apoptosis	Cancer
(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective *proteasome* inhibitor, and potently inhibits 20S proteasome (K_i of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans .

HY-N14940

Phepropeptin D	Proteasome	Inflammation/Immunology
Phepropeptin D, a microbial secondary metabolite, is a *proteasome* inhibitor with an IC₅₀ of 7.8 μg/mL .

HY-N14929

Phepropeptin C	Proteasome	Inflammation/Immunology
Phepropeptin C, a microbial secondary metabolite, is a *proteasome* inhibitor with an IC₅₀ of 12.5 μg/mL .

HY-149514

BC-05	Proteasome	Cancer
BC-05 is an orally active and potent inhibitor of CD13 and *proteasome. BC-05 has an IC₅₀* value of 0.13 μM for human CD13 and an IC₅₀ value of 1.39 μM for the 20S proteasome. BC-05 can be used in multiple myeloma research .

HY-153582

ML 2-23	PROTACs Bcr-Abl	Cancer
ML 2-23 is a potent PROTAC BCR-ABL degrader. ML 2-23 is selectively degrade BCR-ABL in a proteasome-dependent manner in leukemia cells .

HY-P2016

Ac-Nle-Pro-Nle-Asp-AMC	Proteasome	Others
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .

HY-129867

Z-Leu-Leu-Leu-AMC Z-LLL-AMC	Proteasome	Others
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .

HY-117398

HCI-2184	NEKs	Cancer
HCI-2184 is a Nek2 inhibitor with an IC₅₀ of 39.90 nM. HCI-2184 significantly increases the effectiveness of Bortezomib (HY-10227) in inhibiting proteasome activity .

HY-169351

Boc3Arg	Proteasome	Cancer
Boc 3 Arg is the tert-butyl carbamate-protected arginine. Boc 3 Arg is an efficient tag to induce degradation through directly localizing the protein to the 20S proteasome .

HY-123053

Z-Leu-Leu-Glu-AMC Z-LLE-AMC	Proteasome	Others
Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome

HY-169144

Bortezomib analog	Proteasome	Cancer
Bortezomib analog (Compound 13), an analog of Bortezomib (HY-10227), is an active control of 20S proteasome subunit β5 ligand.

HY-168048

ZINC09518833	Proteasome	Cancer
ZINC09518833 is a α-ketoamide nonpeptidic *proteasome* inhibitor with an IC₅₀ value of 12.4 μM. ZINC09518833 binds both primed and nonprimed sites of the proteasome. ZINC09518833 is promising for research of multiple myeloma (MM) .

HY-125939

Bortezomib-pinanediol	Proteasome	Cancer
Bortezomib-pinanediol is a *proteasome* inhibitor and a prodrug of Bortezomib (HY-10227). Bortezomib-pinanediol inhibits cell growth and can be used for study of multiple myeloma .

HY-137286

Z-Leu-Leu-Glu-βNA Z-Leu-Leu-Glu-β-naphthylamide	Proteasome	Others
Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome .

HY-W054146

RAMB4 1 Publications Verification	Proteasome	Cancer
RAMB4 is a *ubiquitin-proteasome* system (UPS)-stressor*. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome* catalytic activities. Anticancer activity .

HY-144980

E3 ligase Ligand 21	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 21 (compound 2) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .

HY-144983

E3 ligase Ligand 22	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 22 (compound 139) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .

HY-155103

Antitrypanosomal agent 15	Proteasome Parasite	Infection
Antitrypanosomal agent 15 (compound 26) is an orally active, brain-penetrant, selective inhibitor against **Trypanosoma cruzi proteasome, with an _pIC₅₀** of 7.4 and <4 for T. cruzi and human proteasome, respectively. Antitrypanosomal agent 15 has favorable ADME properties and can be used for Chagas disease study .

HY-144985

E3 ligase Ligand 23	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 23 (compound 17-6) is a cereblon binder for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway .

HY-163770

Anticancer agent 233	Proteasome	Cancer
Anticancer agent 233 (compound 5g) is a 3,5-bis(arylmethylene)-4-piperidinone derivative with anticancer activity, with GI₅₀ of 0.25 and 0.23 μM for cervical cancer (HeLa) and colon cancer (HCT116) cell lines, respectively. The chlorine atom on the aromatic ring of Anticancer agent 233 interacts well with the catalytic site of 20S proteasome, inhibiting the activity of 20S proteasome to exert its anticancer effect .

Cat. No.	Product Name

HY-L050

Ubiquitination Compound Library

305 compounds

Protein ubiquitination is an enzymatic post-translational modification in which an ubiquitin protein is attached to a substrate protein. Ubiquitination involves three main steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. Ubiquitination affects cellular processes such as apoptosis, cell cycle, DNA damage repair, and membrane transportation, etc. by regulating the degradation of proteins (via the proteasome and lysosome), altering the cellular localization of proteins, affecting proteins activity, and promoting or preventing protein-protein interactions. Deregulation of ubiquitin pathway leads to many diseases such as neurodegeneration, cancer, infection and immunity, etc.

MCE offers a unique collection of 305 small molecule modulators with biological activity used for ubiquitination research. Compounds in this library target the key enzymes in ubiquitin pathway. MCE Ubiquitination Compound Library is a useful tool for the research of ubiquitination regulation and the corresponding diseases.

HY-L151

PROTAC Library

329 compounds

PROTACs (Proteolysis-targeting chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy.

MCE supplies a unique collection of 329 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc.

HY-L012

Metabolism/Protease Compound Library

5,228 compounds

Metabolism is the set of life-sustaining chemical reactions in organisms. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of natural product small molecules within a cell or tissue. Acting as catalysts, enzymes are crucial to metabolism - they allow a reaction to proceed more rapidly - and they also allow the regulation of the rate of a metabolic reaction. Proteases are used throughout an organism for various metabolic processes. Proteases control a great variety of physiological processes that are critical for life, including the immune response, cell cycle, cell death, wound healing, food digestion, and protein and organelle recycling. Imbalances in metabolic activities have been found to be critical in a number of pathologies, such as cardiovascular diseases, inflammation, cancer, and neurodegenerative diseases.

MCE designs a unique collection of 5,228 Metabolism/Protease-related small molecules that act as a useful tool for drug discovery of metabolism-related diseases.

HY-L085

Anti-Parkinson's Disease Compound Library

1,579 compounds

Parkinson’s disease (PD), the second most common age-associated neurodegenerative disorder, is characterized by the loss of dopaminergic (DA) neurons and the presence of α-synuclein-containing aggregates in the substantia nigra pars compacta (SNpc). Motor features such as tremor, rigidity, bradykinesia and postural instability are common traits of PD. To date, there is no treatment to stop or at least slow down the progression of the disease. The etiology and pathogenesis of PD is still elusive, however, a large body of evidence suggests a prominent role of oxidative stress, inflammation, apoptosis, mitochondrial dysfunction and proteasome dysfunction in the pathogenesis of PD.

MCE offers a unique collection of 1,579 compounds with anti- Parkinson’s Disease activities or targeting the unique targets of PD. MCE Anti- Parkinson's Disease Compound Library is a useful tool for exploring the mechanism of PD and discovering new drugs for PD.

HY-L137

Molecular Glue Compound Library

54 compounds

Targeted protein degradation(TPD) is a novel and promising approach to new drug discovery and development. It shows great potential for treating diseases with “undruggable” pathogenic protein targets and for overcoming drug resistance. Molecular glues and PROTACs are both targeted protein degraders that have attracted the most attention.

Molecular glues are small molecular degraders that mainly induce novel interaction between an E3 ligase and a target protein to form a ternary complex, leading to protein ubiquitination and subsequent proteasome degradation. Compared with PROTACs, molecular glues generally possess more favorable drug-like properties, such as lower MW, higher cell permeability, and better oral absorption. Molecular glues are emerging as a promising new therapeutic strategy.

MCE supplies a unique collection of 54 molecular glues which target various proteins. MCE Molecular Glue Compound Library is a useful tool to conduct scientific research and disease mechanism study.

HY-L129

Target Protein Ligand Library

55 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 55 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

HY-L128

E3 Ligase Ligand Library

61 compounds

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 61 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

Cat. No.	Product Name	Target	Research Area

HY-P3414A

Proteasome-activating peptide 1 TFA 1 Publications Verification	Proteasome	Neurological Disease
Proteasome-activating peptide 1 TFA is a peptide and a potent proteasome activator. Proteasome-activating peptide 1 TFA increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 TFA prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis .

HY-P1258

PSI proteasome Inhibitor 1; Z-Ile-Glu(OtBu)-Ala-Leu-CHO	Proteasome	Infection Cancer
PSI (Proteasome Inhibitor 1) is a potent *proteasome* inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas .

HY-134961

Z-Ala-Arg-Arg-AMC Fluorogenic proteasome Substrate; Z-ARR-AMC	Proteasome	Others
Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorogenic substrate for assaying trypsin-like activity of proteasome .

HY-P10003B

iso-VQA-ACC acetate	Proteasome	Others
iso-VQA-ACC acetate is a substrate for constitutive proteasome .

HY-P3414

Proteasome-activating peptide 1	Proteasome	Neurological Disease
Proteasome-activating peptide 1 is a peptide, which increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis .

HY-P1258A

PSI TFA proteasome Inhibitor 1 TFA; Z-Ile-Glu(OtBu)-Ala-Leu-CHO TFA	Proteasome	Infection Cancer
PSI (TFA) is a potent *proteasome* inhibitor. PSI (TFA) inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI (TFA) can be used for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas .

HY-158150

*20S Proteasome-IN-5*	Proteasome	Cancer
20S Proteasome-IN-5 (Compound 5) is a macrocyclic inhibitor of the 20S Proteasome, with IC₅₀ values of 0.19 and 52.5 μM for ChT-L and PGPH-L activity, respectively .

HY-P10060

Boc-Val-Gly-Arg-AMC	Biochemical Assay Reagents	Others
Boc-Val-Gly-Arg-AMC is a peptide substrate that can be used to study activity of the proteasome .

HY-P10003

iso-VQA-ACC	Proteasome	Cancer
iso-VQA-ACC is a substrate for constitutive proteasome .

HY-P10003A

iso-VQA-ACC TFA	Proteasome	Others
iso-VQA-ACC TFA is a constitutive proteasome substrate .

HY-135070

Ac-RLR-AMC Ac-Arg-Leu-Arg-AMC	Proteasome	Others
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .

HY-P10317

Suc-YVAD-AMC	Fluorescent Dye	Others
Suc-YVAD-AMC is used to measure the cysteine proteins of the proteasome.Suc-YVAD-AMC releases fluorescent AMC when cleaved by cysteine proteases to assess the enzymatic activity of the proteasome .

HY-115391

Boc-LRR-AMC Boc-Leu-Arg-Arg-AMC	Biochemical Assay Reagents	Others
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .

HY-137281

HMB-Val-Ser-Leu-VE	Ser/Thr Protease	Others
HMB-Val-Ser-Leu-VE is a prototype vinyl ester inhibitor. HMB-Val-Ser-Leu-VE is against trypsin-like (T-L) proteasome activity with an IC₅₀ of 0.033 μM .

HY-P2016

Ac-Nle-Pro-Nle-Asp-AMC	Proteasome	Others
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis .

HY-129867

Z-Leu-Leu-Leu-AMC Z-LLL-AMC	Proteasome	Others
Z-Leu-Leu-Leu-AMC is a fluorogenic substrate for measuring the chymotrypsin-like protease activity of the 20S proteasome .

HY-123053

Z-Leu-Leu-Glu-AMC Z-LLE-AMC	Proteasome	Others
Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome

HY-137286

Z-Leu-Leu-Glu-βNA Z-Leu-Leu-Glu-β-naphthylamide	Proteasome	Others
Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for determination of the glutamylpeptidyl-peptide hydrolase activity of the 20S proteasome .

HY-123051

Ac-WLA-AMC	Proteasome	Inflammation/Immunology
Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate .

HY-P4284

Z-GGF-CMK	ClpP Proteasome	Others
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC₅₀ value of 125 μM .

HY-P1259

PR-39	Proteasome Bacterial	Inflammation/Immunology
PR-39, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric *proteasome* inhibitor. PR-39 reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-P1259A

PR-39 TFA	Proteasome Bacterial	Inflammation/Immunology
PR-39 TFA, a natural proline- and arginine-rich antibacterial peptide, is a noncompetitive, reversible and allosteric *proteasome* inhibitor. PR-39 TFAreversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway. PR-39 TFA stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice .

HY-135070B

Ac-RLR-AMC TFA Ac-Arg-Leu-Arg-AMC TFA	Proteasome	Others
Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA is a fluorogenic substrate for the 26S proteasome (Ex/Em: 380/440-460 nm). AMC is released upon cleavage, and its fluorescence can be used to quantify the trypsin-like activity of 26S proteasomes .

HY-W753820A

Boc-LRR-AMC TFA Boc-Leu-Arg-Arg-AMC TFA	Biochemical Assay Reagents	Others
Boc-LRR-AMC TFA (Boc-Leu-Arg-Arg-AMC TFA) is the TFA salt form of Boc-LRR-AMC (HY-115391). Boc-LRR-AMC TFA is a fluorogenic substrate, which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core .

HY-P4514

Z-Gly-Gly-Arg-βNA	Proteasome	Others
Z-Gly-Gly-Arg-βNA is the synthetic peptide substrate of trypsin-like activities of the proteasome .

HY-P5280

Ac-KQL-AMC	Ser/Thr Protease	Others
Ac-KQL-AMC is a fluorogenic substrate that can be used to quantify Trypsin-like activity, resulting in detectable fluorescence when cleaved by the proteasome .

HY-P5819

xStAx-VHLL	Wnt PROTACs β-catenin	Cancer
xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P4910

Baceridin	Proteasome Apoptosis	Cancer
Baceridin is a proteasome inhibitor and a cyclic hexapeptide. Baceridin can be isolated from the culture medium of Epiphytic Bacillus. Baceridin can inhibit cell cycle progression and induce tumor cell apoptosis through a p53-independent pathway. Baceridin can be used in cancer research .

HY-P5819A

xStAx-VHLL TFA	PROTACs β-catenin Wnt	Cancer
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL TFA inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P10438

Tat-braftide	Raf	Cancer
Tat-braftide is a peptide inhibitor designed to block the dimerization of BRAF, thereby inhibiting its kinase activity. The destruction of BRAF dimer by Tat-braftide makes BRAF protein more susceptible to proteasome degradation, directly inhibits the activity of BRAF kinase, and reduces the activation of MAPK signaling pathway. Tat-braftide can be used for the role of RAF kinase in MAPK signaling pathway and for the study of BRAF mutant cancers .

HY-P10714

Ub4ix	Proteasome Apoptosis Deubiquitinase	Cancer
Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC₅₀ value of 1.6 μM .

Cat. No.	Product Name	Target	Research Area

HY-P9915

Daratumumab 1 Publications Verification Anti-Human CD38, Human Antibody	CD38 ADC Antibody	Inflammation/Immunology Cancer
Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-P9915A

Daratumumab (PBS) 1 Publications Verification Anti-Human CD38, Human Antibody (PBS)	ADC Antibody CD38	Cancer
Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-P99672

Istiratumab MM 141; MM-005	IGF-1R EGFR	Cancer
Istiratumab (M-6495) is bispecific monoclonal antibody targeting IGF-1R and ErbB3. Istiratumab induces IGF-1R and ErbB3 receptor degradation through the proteasome pathway Istiratumab can be used for research of cancers .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7056

4'-Hydroxychalcone	Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Chalcones Monophenols Flavonoids Leguminosae Phenols Inflammation/Immunology Disease Research Fields Glycyrrhiza uralensis Fisch.	Oxidative Phosphorylation Proteasome
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via *proteasome* inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria .

HY-N14927

Phepropeptin A	Structural Classification Natural Products Microorganisms Source classification	Proteasome
Phepropeptin A, a microbial secondary metabolite, is a *proteasome* inhibitor with an IC₅₀ of 21 μg/mL .

HY-N14928

Phepropeptin B	Structural Classification Natural Products Microorganisms Source classification	Proteasome
Phepropeptin B, a microbial secondary metabolite, is a *proteasome* inhibitor with an IC₅₀ of 11 μg/mL .

HY-N14940

Phepropeptin D	Structural Classification Natural Products Microorganisms Source classification	Proteasome
Phepropeptin D, a microbial secondary metabolite, is a *proteasome* inhibitor with an IC₅₀ of 7.8 μg/mL .

HY-N14929

Phepropeptin C	Structural Classification Natural Products Microorganisms Source classification	Proteasome
Phepropeptin C, a microbial secondary metabolite, is a *proteasome* inhibitor with an IC₅₀ of 12.5 μg/mL .

HY-N15130

Cerpegin	Apocynaceae Ceropegia junceaRoxb. Structural Classification Alkaloids Source classification Pyridine Alkaloids Plants	Proteasome
Cerpegin, a pyridinone-fused c-lactone, is an inhibitor of 20S proteasome. Cerpegin can be used as a tranquillizer, anti-inflammatory, analgesic and antiulcer .

HY-N10332

Leptosphaerodione	Quinones Monophenols Microorganisms Classification of Application Fields Source classification Phenols Naphthalene Quinones Disease Research Fields Cancer	Proteasome
Leptosphaerodione, isolated from Remotididymella sp. Fungus, is a potent *ubiquitin-proteasome* system (UPS**) inhibitor. Leptosphaerodione exhibits cytotoxicity in HeLa cells with IC₅₀ value of 3.2 μM. Anti-tumor agent .

HY-13067R

Celastrol (Standard)	Triterpenes Structural Classification Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants	Proteasome Autophagy Mitophagy Apoptosis Endogenous Metabolite
Celastrol (Standard) is the analytical standard of Celastrol. This product is intended for research and analytical applications. Celastrol (Tripterine;Tripterin) is a proteasome inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM.

HY-N11620

Sadopeptins A	Structural Classification Monophenols Microorganisms Source classification Phenols	Proteasome
Sadopeptins A is a nature product that could be isolated from Streptomyces sp. Sadopeptins A is a potent proteasome inhibitor .

HY-N11621

Sadopeptins B	Structural Classification Monophenols Microorganisms Source classification Phenols	Proteasome
Sadopeptins B is a nature product that could be isolated from Streptomyces sp. Sadopeptins B is a potent proteasome inhibitor .

HY-10985

Marizomib 10+ Cited Publications Salinosporamide A; NPI-0052	Marine natural products Source classification Marine microorganism	Proteasome
Marizomib (Salinosporamide A) is a second-generation, irreversible, brain-penetrant, *pan-proteasome* inhibitor. Marizomib inhibits the CT-L (β5), CT-T-laspase-like (C-L, β1) and trypsin-like (T-L, β2) activities of the 20S proteasome (IC₅₀=3.5, 28, and 430 nM, respectively) .

HY-13067

Celastrol Maximum Cited Publications 38 Publications Verification Tripterine; Tripterin	Triterpenes Structural Classification Classification of Application Fields Anti-aging Terpenoids Source classification Celastraceae Tripterygium wilfordii Hook. f. Plants Inflammation/Immunology Disease Research Fields Cancer	Proteasome Autophagy Mitophagy Apoptosis Endogenous Metabolite Antibiotic Bacterial
Celastrol (Tripterine;Tripterin) is a *proteasome* inhibitor which potently and preferentially inhibits the chymotrypsin-like activity of a purified 20S proteasome with IC₅₀ of 2.5 μM. In addition, Celastrol is also an antibiotic with potent antimicrobial activity against standard and clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, inducing oxidative stress and inhibiting DNA synthesis by binding to P5CDH .

HY-108549

clasto-Lactacystin β-lactone Omuralide; β-Clastolactacystin	Classification of Application Fields Disease Research Fields Cancer	Proteasome
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.

HY-13821

Epoxomicin 10+ Cited Publications BU-4061T	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Inflammation/Immunology Disease Research Fields	Proteasome Apoptosis
Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible *proteasome* inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the *proteasome* and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity .

HY-N2117

Isoginkgetin 10+ Cited Publications	Structural Classification Flavonoids Ginkgoaceae Classification of Application Fields Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba Disease Research Fields Cancer	MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy .

HY-N0375

18α-Glycyrrhetinic acid	Triterpenes Structural Classification Neurological Disease Classification of Application Fields Leguminosae Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields	Proteasome NF-κB Apoptosis
18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of *proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis* .

HY-N2166

Tomatine α-Tomatine; Lycopersicin; Tomatin	Structural Classification Source classification Solanum lycopersicum L. Solanaceae Plants Steroids	Proteasome Apoptosis
Tomatine is a glycoalkaloid, found in the tomato plant (Lycopersicon esculentum Mill.). Tomatine elicits neurotoxicity in RIP1 kinase and caspase-independent manner. Tomatine promotes the upregulation of nuclear apoptosis inducing factor (AIF) in neuroblastoma cells. Tomatine also inhibits 20S proteasome activity .

HY-N2117R

Isoginkgetin (Standard)	Structural Classification Flavonoids Ginkgoaceae Source classification Phenols Polyphenols Plants Biflavones Ginkgo biloba	MMP Akt NF-κB Proteasome Apoptosis Autophagy
Isoginkgetin (Standard) is the analytical standard of Isoginkgetin. This product is intended for research and analytical applications. Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy .

HY-N0415

Trigonelline chloride 4 Publications Verification Trigonelline hydrochloride	Infection Alkaloids Structural Classification Classification of Application Fields Labiatae Source classification Pyridine Alkaloids Metabolic Disease Lactuca perennis Plants Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0414

Trigonelline 4 Publications Verification Trigenolline	Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Plants Endogenous metabolite Alkaloids Microorganisms other families Leguminosae Trigonella foenum-graecum Linn. Disease Research Fields	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N7695

Physalin B	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	Apoptosis Autophagy
Physalin B, one of the major active steroidal constituents of Cape gooseberry, induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro .

HY-N0375R

18α-Glycyrrhetinic acid (Standard)	Triterpenes Structural Classification Leguminosae Terpenoids Source classification Plants Glycyrrhiza uralensis Fisch.	Proteasome NF-κB Apoptosis
18α-Glycyrrhetinic acid (Standard) is the analytical standard of 18α-Glycyrrhetinic acid. This product is intended for research and analytical applications. 18α-Glycyrrhetinic acid, a diet-derived compound, is an inhibitor of NF-kB and an activator of proteasome, which serves as pro-longevity and anti-aggregation factor in a multicellular organism. 18α-Glycyrrhetinic acid induces apoptosis .

HY-N0414R

Trigonelline (Standard)	Alkaloids Structural Classification Microorganisms other families Leguminosae Source classification Pyridine Alkaloids Plants Endogenous metabolite Trigonella foenum-graecum Linn.	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline (Standard) is the analytical standard of Trigonelline. This product is intended for research and analytical applications. Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.

HY-N0415R

Trigonelline (chloride) (Standard)	Alkaloids Structural Classification Labiatae Source classification Pyridine Alkaloids Lactuca perennis Plants	Endogenous Metabolite Ferroptosis Apoptosis HIV Bacterial Fungal
Trigonelline (chloride) (Standard) is the analytical standard of Trigonelline (chloride). This product is intended for research and analytical applications. Trigonelline chloride is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline chloride is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline chloride also has anti-HSV-1, antibacterial, and antifungal activity, and induces ferroptosis.

HY-N0060B

(E)-Ferulic acid (E)-Coniferic acid	Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Monophenols Microorganisms other families Simple Phenylpropanols Phenols Phenylpropanoids Disease Research Fields Cancer	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite
(E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

HY-16594

Lactacystin 3 Publications Verification	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Proteasome Apoptosis ROS Kinase
Lactacystin is a potent, orally active, irreversible, cell-permeable, selective 20S *proteasome* inhibitor (IC₅₀ = 4.8 μM). Lactacystin also inhibits the lysosomal enzyme cathepsin A. Lactacystin inhibits cell growth and induces apoptosisand cell cycle arrest, and has antiviral and antioxidative activity. Lactacystin induces neurite outgrowth and hypertension. Lactacystin has the potential for the research of cancer, Neurological Disease, hypertension and Malaria, and so on ^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7] ^[8] ^[9] ^[10].

HY-N0060BR

(E)-Ferulic acid (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms other families Simple Phenylpropanols Source classification Phenols Phenylpropanoids Plants Endogenous metabolite	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite
(E)-Ferulic acid (Standard) is the analytical standard of (E)-Ferulic acid. This product is intended for research and analytical applications. (E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

Species:	Human (17) Mouse (3)
Tag:	His (16) Tag Free (4) Strep (2) Avi (8)
Source:	HEK293 (8) Sf9 insect cells (1) E. coli (11)

Cat. No.	Compare	Product Name	Species	Source

HY-P76554

	PSME3 Protein, Human (His) proteasome activator complex subunit 3; REG-gamma; PA28g; PSME3	Human	E. coli
	PSME3 is a subunit of the 11S REG-gamma proteasome modulator that forms a homoheptamer and is essential for activating the trypsin-like subunit of the proteasome and inhibiting the chymotrypsin-like and PGPH subunits. PSME3 promotes MDM2-p53 interaction, leading to p53 degradation and inhibiting apoptosis after DNA damage. PSME3 Protein, Human (His) is the recombinant human-derived PSME3 protein, expressed by E. coli , with N-His labeled tag. The total length of PSME3 Protein, Human (His) is 254 a.a., with molecular weight of 28-33 kDa.

HY-P75988

	PSMA3 Protein, Human (His) proteasome subunit alpha type-3; Macropain subunit C8; PSMA3; HC8; PSC8	Human	E. coli
	PSMA3 is a protein involved in protein degradation. PSMA3 Protein, Human (His) is the recombinant human-derived PSMA3 protein, expressed by E. coli , with N-His labeled tag.

HY-P76554A

	PSME3 Protein, Human (N-His) proteasome activator complex subunit 3; REG-gamma; PA28g; PSME3	Human	E. coli
	PSME3 is a subunit of the 11S REG-gamma proteasome modulator that forms a homoheptamer and is essential for activating the trypsin-like subunit of the proteasome and inhibiting the chymotrypsin-like and PGPH subunits. PSME3 promotes MDM2-p53 interaction, leading to p53 degradation and inhibiting apoptosis after DNA damage. PSME3 Protein, Human (N-His) is the recombinant human-derived PSME3 protein, expressed by E. coli , with N-His labeled tag.

HY-P701467

	PSMD7 Protein, Human (Sf9) PSMD7; 26S proteasome non-ATPase regulatory subunit 7; 26S proteasome regulatory subunit RPN8; 26S proteasome regulatory subunit S12; Mov34 protein homolog; proteasome subunit p40	Human	Sf9 insect cells
	The PSMD7 protein is a component of the 26S proteasome and promotes the ATP-dependent degradation of ubiquitinated proteins. It maintains protein homeostasis by eliminating misfolded or unnecessary proteins, thereby protecting cellular function. PSMD7 Protein, Human (Sf9) is the recombinant human-derived PSMD7 protein, expressed by Sf9 insect cells , with tag free. The total length of PSMD7 Protein, Human (Sf9) is 323 a.a., .

HY-P70213

	Gankyrin/PSMD10 Protein, Human rHu26S proteasome non-ATPase regulatory subunit 10/PSMD10; 26S proteasome Non-ATPase Regulatory Subunit 10; 26S proteasome Regulatory Subunit p28; Gankyrin; p28(GANK); PSMD10	Human	E. coli
	Gankyrin/PSMD10 protein is a key partner in 26S proteasome assembly and contributes to the formation of the PA700/19S regulatory complex (RC). In basal subcomplex assembly, it engages PSMD10, PSMC4, PSMC5, and PAAF1, and possibly PSMD5, PSMC2, PSMC1, and PSMD2. Gankyrin/PSMD10 Protein, Human is the recombinant human-derived Gankyrin/PSMD10 protein, expressed by E. coli , with tag free.

HY-P75989

	PSMB6 Protein, Mouse (His) proteasome subunit beta type-6; Psmb6; Lmp19	Mouse	E. coli
	PSMB6 protein is a component of the 20S core proteasome complex and participates in ubiquitin-dependent protein degradation within the 26S proteasome.This complex maintains protein homeostasis by eliminating misfolded or unnecessary proteins.PSMB6 Protein, Mouse (His) is the recombinant mouse-derived PSMB6 protein, expressed by E.coli , with N-His labeled tag.

HY-P701388

	PSMG3 Protein, Human PSMG3; proteasome assembly chaperone 3; PAC-3; hPAC3	Human	E. coli
	The PSMG3 protein acts as a chaperone and actively promotes the assembly of the 20S proteasome. It involves potential cooperation with the PSMG1-PSMG2 heterodimer to ensure precise assembly of the proteasome. PSMG3 Protein, Human is the recombinant human-derived PSMG3 protein, expressed by E. coli , with tag free. The total length of PSMG3 Protein, Human is 122 a.a., .

HY-P701390

	PSMG4 Protein, Human PSMG4; proteasome assembly chaperone 4; PAC-4; hPAC4	Human	E. coli
	PSMG4 protein functions as a chaperone, facilitating the assembly of the 20S proteasome. In its role as a chaperone, PSMG4 interacts with PSMG3, forming a functional complex that contributes to the proper assembly of the 20S proteasome. Notably, PSMG4 associates specifically with the alpha subunits of the 20S proteasome, highlighting its involvement in the intricate process of proteasomal maturation and functionality. PSMG4 Protein, Human is the recombinant human-derived PSMG4 protein, expressed by E. coli , with tag free. The total length of PSMG4 Protein, Human is 123 a.a., .

HY-P701389

	PSMG3 Protein, Human (His, StrepⅡ) PSMG3; proteasome assembly chaperone 3; PAC-3; hPAC3	Human	E. coli
	The PSMG3 protein acts as a chaperone and actively promotes the assembly of the 20S proteasome. It involves potential cooperation with the PSMG1-PSMG2 heterodimer to ensure precise assembly of the proteasome. PSMG3 Protein, Human (His, Strep) is the recombinant human-derived PSMG3 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of PSMG3 Protein, Human (His, Strep) is 122 a.a., .

HY-P701391

	PSMG4 Protein, Human (His, StrepⅡ) PSMG4; proteasome assembly chaperone 4; PAC-4; hPAC4	Human	E. coli
	PSMG4 protein functions as a chaperone, facilitating the assembly of the 20S proteasome. In its role as a chaperone, PSMG4 interacts with PSMG3, forming a functional complex that contributes to the proper assembly of the 20S proteasome. Notably, PSMG4 associates specifically with the alpha subunits of the 20S proteasome, highlighting its involvement in the intricate process of proteasomal maturation and functionality. PSMG4 Protein, Human (His, Strep) is the recombinant human-derived PSMG4 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of PSMG4 Protein, Human (His, Strep) is 123 a.a., .

HY-P75990

	PSME1 Protein, Human (His) proteasome activator complex subunit 1; REG-alpha; IGUP I-5111; PA28a; IFI5111	Human	E. coli
	The PSME1 protein is critical for immunoproteasome assembly and is essential for efficient antigen processing. As part of the PA28 activator complex, PSME1, together with PSME2, actively enhances the production of class I binding peptides by altering the cleavage pattern of the proteasome. PSME1 Protein, Human (His) is the recombinant human-derived PSME1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of PSME1 Protein, Human (His) is 248 a.a., with molecular weight of ~29 kDa.

HY-P75991

	PSME2 Protein, Human (His) proteasome activator complex subunit 2; REG-beta; PA28beta; PA28b; PSME2	Human	E. coli
	PSME2 Protein, vital for immunoproteasome assembly, is crucial for efficient antigen processing. In collaboration with PSME1, the PA28 activator complex modifies the proteasome's cleavage pattern, actively contributing to class I binding peptide generation. The hexameric ring structure of this heterodimeric complex underscores its significance in orchestrating processes essential for immune responses and antigen presentation. PSME2 Protein, Human (His) is the recombinant human-derived PSME2 protein, expressed by E. coli , with N-His labeled tag. The total length of PSME2 Protein, Human (His) is 239 a.a., with molecular weight of ~29 kDa.

HY-P77766

	*HLA-A0201 LMP2 Complex Protein, Human (HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; proteasome chain 7; PSMB9; RING12	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 LMP2 Complex Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 LMP2 Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 LMP2 Complex Protein, Human (HEK293, His-Avi), has molecular weight of 52-56 kDa.

HY-P77767

	*HLA-A0201 LMP2 Complex Protein, Human (Biotinylated, HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; proteasome chain 7; PSMB9; RING12	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 LMP2 Complex Protein, Human (Biotinylated, HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 LMP2 Complex protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 LMP2 Complex Protein, Human (Biotinylated, HEK293, His-Avi), has molecular weight of 51-60 kDa.

HY-P77768

	*HLA-A0201 LMP2 Complex Tetramer Protein, Human (HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; proteasome chain 7; PSMB9; RING12	Human	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. HLA-A0201 LMP2 Complex Tetramer Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived HLA-A0201 LMP2 Complex Tetramer protein, expressed by HEK293 , with C-Avi, C-His labeled tag. HLA-A*0201 LMP2 Complex Tetramer Protein, Human (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P77771

	*Chimeric HLA-A0201 LMP2 Protein, Human&Mouse (HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; proteasome chain 7; PSMB9; RING12	Mouse	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. Chimeric HLA-A0201 LMP2 Protein, Human&Mouse (HEK293, His-Avi) is the recombinant mouse-derived Chimeric HLA-A0201 LMP2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. Chimeric HLA-A*0201 LMP2 Protein, Human&Mouse (HEK293, His-Avi), has molecular weight of 52-65 kDa.

HY-P700933

	*HLA-A1101 LMP2 Complex Protein, Human (SSCSSCPLTK, HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; proteasome chain 7; PSMB9; RING12	Human	HEK293
	HLA-A1101as is a key MHCI molecule that presents viral and tumor-derived peptides that direct T cell immune responses against infected or transformed cells. It collaborates with B2M to showcase a diverse peptide library. HLA-A1101 LMP2 Complex Protein, Human (SSCSSCPLTK, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-A1101 and B2M/Beta-2-microglobulin Protein, expressed by HEK293* , with C-Avi, C-His labeled tag and SSCSSCPLTK peptide. HLA-A*1101 LMP2 Complex Protein, Human (SSCSSCPLTK, HEK293, His-Avi), has molecular weight of 51-60 kDa.

HY-P77772

	*Chimeric HLA-A0201 LMP2 Tetramer Protein, Human&Mouse (HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; proteasome chain 7; PSMB9; RING12	Mouse	HEK293
	HLA-A0201 MAGE-A4 Complex Protein, a member of the major histocompatibility complex (MHC) class I family, is highlighted. Additionally, the Chimeric HLA-A0201 WT-1 Complex Tetramer is recognized within the MHC class I family. Chimeric HLA-A0201 LMP2 Tetramer Protein, Human&Mouse (HEK293, His-Avi) is the recombinant mouse-derived Chimeric HLA-A0201 LMP2 Tetramer protein, expressed by HEK293 , with C-Avi, C-His labeled tag. Chimeric HLA-A*0201 LMP2 Tetramer Protein, Human&Mouse (HEK293, His-Avi), has molecular weight of 260-265 kDa.

HY-P700932

	*HLA-A1101 LMP2 Complex Protein, Human (Biotinylated, SSCSSCPLTK, HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; proteasome chain 7; PSMB9; RING12	Human	HEK293
	HLA-A1101as, a pivotal MHCI molecule, presents viral and tumor-derived peptides, guiding T cell immune responses against infected or transformed cells. Collaborating with B2M, it displays a diverse peptide repertoire. Both the presented peptide and MHCI contribute to antigen recognition specificity. HLA-A1101 typically presents 8 to 13 amino acid intracellular peptides, binding different peptides with allele-specific motifs. It plays a crucial role in controlling infections, presenting immunodominant epitopes from HIV-1, EBV, HBV, and contributing to the immune response against SARS-CoV-2. HLA-A1101 LMP2 Complex Protein, Human (Biotinylated, SSCSSCPLTK, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-A1101 and B2M/Beta-2-microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and SSCSSCPLTK peptide. HLA-A*1101 LMP2 Complex Protein, Human (Biotinylated, SSCSSCPLTK, HEK293, His-Avi), has molecular weight of 51-60 kDa.

HY-P700934

	*HLA-A1101 LMP2 Complex Tetramer Protein, Human (SSCSSCPLTK, HEK293, His-Avi)** MHC; RMF; LMP2; LMP-2; Macropain chain 7; proteasome chain 7; PSMB9; RING12	Human	HEK293
	HLA-A1101as is a key MHCI molecule that presents viral and tumor-derived peptides that direct T cell immune responses against infected or transformed cells. It collaborates with B2M to showcase a diverse peptide library. HLA-A1101 LMP2 Complex Tetramer Protein, Human (SSCSSCPLTK, HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-A1101 and B2M/Beta-2-microglobulin Protein, expressed by HEK293* , with C-Avi, C-His labeled tag and SSCSSCPLTK peptide. HLA-A*1101 LMP2 Complex Tetramer Protein, Human (SSCSSCPLTK, HEK293, His-Avi), has molecular weight of 260-265 kDa.

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Cat. No.	Product Name	Chemical Structure

HY-10227S

Bortezomib-d8
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity[1][2].

HY-10455S

Carfilzomib-d8
Carfilzomib-d₈ is deuterium labeled Carfilzomib. Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.

HY-W748328

Ixazomib-13C2,15N
Ixazomib- ¹³C₂, ¹⁵N is ¹³C and ¹⁵N labeled Ixazomib. Ixazomib (MLN2238) is a selective, potent, and reversible *proteasome* inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC₅₀ of 3.4 nM (K_i of 0.93 nM) .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80437

	Proteasome 20S LMP7 Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Proteasome 20S LMP7 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 30 kDa, targeting to Proteasome 20S LMP7. It can be used for WB,ICC,IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80876

	Proteasome beta 8 Antibody (YA684) PSMB8; LMP7; PSMB5i; RING10; Y2; proteasome subunit beta type-8; Low molecular mass protein 7; Macropain subunit C13; Multicatalytic endopeptidase complex subunit C13; proteasome component C13; proteasome subunit beta-5i; Really interesting	WB, IHC-F, IHC-P, ICC/IF	Human, Rat
	Proteasome beta 8 Antibody (YA684) is a non-conjugated and Mouse origined monoclonal antibody about 30 kDa, targeting to Proteasome beta 8 (3G3). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Rat.

HY-P83719

	PSMB5/MB1 Antibody DKFZp459C139 antibody; EC 3.4.25.1 antibody; LMPX antibody; Macropain epsilon chain antibody; MB1 antibody; MGC104214 antibody; MGC118075 antibody; MGC134464 antibody; Multicatalytic endopeptidase complex epsilon chain antibody; proteasome (prosome, macropain) subunit, beta type, 5 antibody; proteasome beta 5 subunit antibody; proteasome catalytic subunit 3 antibody; proteasome chain 6 antibody; proteasome epsilon chain antibody; proteasome subunit beta type-5 antibody; proteasome subunit MB1 antibody; proteasome subunit X antibody; proteasome subunit, beta type, 5 antibody; proteasome subunit, beta-5 antibody; PSB5_HUMAN antibody; PSMB5 antibody; PSX large multifunctional protease X antibody; X antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PSMB5/MB1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 26 kDa, targeting to PSMB5/MB1. It can be used for WB, IHC-P, IF-Cell, FC assays with tag free, in the background of Human,Mouse, Rat.

HY-P83718

	PSMB1 Antibody FLJ25321 antibody; HC5 antibody; KIAA1838 antibody; Macropain subunit C5 antibody; Multicatalytic endopeptidase complex subunit C5 antibody; proteasome (prosome macropain) subunit beta type 1 antibody; proteasome beta 1 subunit antibody; proteasome component C5 antibody; proteasome gamma chain antibody; proteasome subunit beta type 1 antibody; proteasome subunit beta type-1 antibody; proteasome subunit HC5 antibody; PSB1_HUMAN antibody; PSC5 antibody; PSMB 1 antibody; PSMB1 antibody	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PSMB1 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 26 kDa, targeting to PSMB1. It can be used for WB, IF-Cell, IHC-P, FC assays with tag free, in the background of Human,Mouse, Rat.

HY-P82641

	PSMA3 Antibody (YA2386) PSMA3; HC8; PSC8; proteasome subunit alpha type-3; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; proteasome component C8	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	PSMA3 Antibody (YA2386) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2386), targeting PSMA3, with a predicted molecular weight of 28 kDa (observed band size: 28 kDa). PSMA3 Antibody (YA2386) can be used for WB, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82556

	PSMA1 Antibody (YA2301) NU; HC2; PROS30; psmA1; PSC2; proteasome 20S C2	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
	PSMA1 Antibody (YA2301) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2301), targeting PSMA1, with a predicted molecular weight of 30 kDa (observed band size: 30 kDa). PSMA1 Antibody (YA2301) can be used for WB, IHC-P, ICC/IF, IP, FC experiment in human, mouse, rat background.

HY-P82004

	Proteasome alpha 6 Antibody (YA1749) proteasome subunit alpha 6; IOTA; p27K; PROS27	WB, ICC/IF	Human, Mouse, Rat
	Proteasome alpha 6 Antibody (YA1749) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1749), targeting Proteasome alpha 6, with a predicted molecular weight of 27 kDa (observed band size: 27 kDa). Proteasome alpha 6 Antibody (YA1749) can be used for WB, ICC/IF experiment in human, mouse, rat background.

HY-P81999

	Proteasome alpha 2 Antibody (YA1744) HC3; PMSA2; proteasome component C3; PSC2; PSC3; psmA2	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Proteasome alpha 2 Antibody (YA1744) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1744), targeting Proteasome alpha 2, with a predicted molecular weight of 26 kDa (observed band size: 26 kDa). Proteasome alpha 2 Antibody (YA1744) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human, mouse, rat background.

HY-P82002

	Proteasome beta 9 Antibody (YA1747) Beta1i; LMP2; PSMB 9; PSMB6i; PSMB9; RING12	WB, ICC/IF	Human, Mouse, Rat
	Proteasome beta 9 Antibody (YA1747) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1747), targeting Proteasome beta 9, with a predicted molecular weight of 23 kDa (observed band size: 23 kDa). Proteasome beta 9 Antibody (YA1747) can be used for WB, ICC/IF experiment in human, mouse, rat background.

HY-P82020

	PSMA4 Antibody (YA1765) proteasome subunit alpha 4; HC9; PSC9; HsT17706	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	PSMA4 Antibody (YA1765) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1765), targeting PSMA4, with a predicted molecular weight of 29 kDa (observed band size: 29 kDa). PSMA4 Antibody (YA1765) can be used for WB, IHC-F, IHC-P, ICC/IF, IP experiment in human, mouse, rat background.

HY-P82639

	PSMA2 Antibody (YA2384) HC3; PMSA2; proteasome component C3; PSC2; PSC3; psmA2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	PSMA2 Antibody (YA2384) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2384), targeting PSMA2, with a predicted molecular weight of 26 kDa (observed band size: 26 kDa). PSMA2 Antibody (YA2384) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P82505

	PSMD14 Antibody (YA2250) 26S proteasome non-ATPase regulatory subunit 14; PAD1; POH1; Psmd14; RPN11	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	PSMD14 Antibody (YA2250) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2250), targeting PSMD14, with a predicted molecular weight of 35 kDa (observed band size: 35 kDa). PSMD14 Antibody (YA2250) can be used for WB, IHC-P, ICC/IF experiment in human, mouse, rat background.