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Tubulin polymerization inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Microtubule/Tubulin (203) ADC Cytotoxin (29) ADC Linker (2) Akt (3) Antibiotic (2) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (87) Autophagy (6) Bacterial (4) Casein Kinase (1) Caspase (3) CDK (1) Drug-Linker Conjugates for ADC (25) EGFR (3) ERK (1) Estrogen Receptor/ERR (1) Farnesyl Transferase (1) Fungal (1) HDAC (3) HIF/HIF Prolyl-Hydroxylase (2) Histone Demethylase (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Isotope-Labeled Compounds (2) JNK (1) Mitochondrial Metabolism (2) MMP (3) mTOR (1) NOD-like Receptor (NLR) (4) Parasite (4) PARP (1) PI3K (2) Polo-like Kinase (PLK) (1) Proton Pump (1) Reactive Oxygen Species (6) Src (1) STAT (1) TGF-beta/Smad (1) Topoisomerase (1) VEGFR (5) YAP (1)
By Research Areas:	Cancer (252) Cardiovascular Disease (2) Infection (5) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	DBCO (3)

258

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

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Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Microtubule/Tubulin

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-152156

Tubulin inhibitor 11	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 11 is a potent and orally active *tubulin* inhibitor. Tubulin inhibitor 11 targets the Colchicine binding site on tubulin, inhibits tubulin polymerization, promotes mitotic blockade and apoptosis .

HY-155359

Tubulin polymerization-IN-55	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-55 is a potent inhibitor of **Tubulin Polymerization*. Tubulin* polymerization-IN-55 has antiproliferative activity against A549, K562, HepG2, MDA-MB-231 and HFL-1 with IC₅₀ s of 8, 3, 9, 24 and 62 nM, respectively .

HY-162126

Tubulin polymerization-IN-58	Microtubule/Tubulin YAP	Cancer
Tubulin polymerization-IN-58 (Compound K18) is a **tubulin polymerization** inhibitor with an IC₅₀ of 0.446 μM. Tubulin polymerization-IN-58 also induces the degradation of oncogenic protein YAP via the UPS pathway, thus can be used for cancer research .

HY-152088

Neuroinflammatory-IN-3	Microtubule/Tubulin	Neurological Disease Inflammation/Immunology Cancer
Neuroinflammatory-IN-3, a *tubulin* inhibitor, is an anti-neuroinflammatory agent. Neuroinflammatory-IN-3 is a potent antitumor agent that functions by the inhibition of tubulin polymerization_[1] .

HY-155139

Tubulin polymerization-IN-45	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-45, a tubulin-targeting agent, is a **tubulin polymerization** inhibitor. Tubulin polymerization-IN-45 binds to the colchicine site of tubulin. Tubulin polymerization-IN-45 induces apoptotic cell death in hepatocellular cancer (HCC) cells .

HY-149016

Tubulin polymerization-IN-25	Microtubule/Tubulin Farnesyl Transferase	Cancer
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of **tubulin polymerization and farnesyl transferase (FTase) with IC₅₀*s of 1.11 μM and 0.39 μM, respectively. Tubulin* polymerization-IN-25 displays cytotoxicity and excellent antitumor activity .

HY-155841

Tubulin polymerization-IN-46	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-46 (compound 9q) is a microtubule/Tubulin inhibitor that inhibits tubulin polymerization and induces apoptosis. Tubulin polymerization-IN-46 inhibits mitosis and arrests MCF-7 cells in the G2/M phase. Tubulin polymerization-IN-46 has anti-proliferative activity against MCF-7 breast cancer cells with an IC₅₀ of 10 nM .

HY-149856

Tubulin inhibitor 33	Microtubule/Tubulin Apoptosis	Cancer
Tubulin inhibitor 33, a *tubulin* polymerization inhibitor, inhibits *tubulin* polymerization in a dose-dependent manner with an IC₅₀ of 9.05 μM. Tubulin inhibitor 33 has antitumor effects and induces cell apoptosis that can be used for antitumor research .

HY-122151

MPT0B002	Microtubule/Tubulin Apoptosis	Cancer
MPT0B002 is a potent microtubule inhibitor with anticancer activities. MPT0B002 disrupts tubulin polymerization, induces apoptosis, and arrests cell cycle at the G2/M phase .

HY-145951

Amidate-VC-PAB-MMAF	Drug-Linker Conjugates for ADC	Cancer
Amidate-VC-PAB-MMAF consists a cleavable ADC linker (Amidate-VC-PAB) and a potent tubulin polymerization inhibitor (MMAF). Amidate-VC-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs). Amidate-VC-PAB-MMAF reduces off-target cytotoxicity of ADCs .

HY-155249

KGP591	Microtubule/Tubulin	Cancer
KGP591 is a *tubulin* polymerization inhibitor (IC₅₀ 0.57 µM). KGP591 induces significant G2/M stagnation, inhibits cell migration, disrupts microtubule structure and cell morphology in MDA-MB-231 cells. KGP591 shows antitumor activity in orthotopic model of kidney cancer (RENCA) .

HY-151393

Tubulin polymerization-IN-32	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-32 is a *tubulin* polymerization inhibitor. Tubulin polymerization-IN-32 inhibits cancer cell proliferation. Tubulin polymerization-IN-32 can be used in the research of cancers like lymphomas .

HY-151397

Tubulin polymerization-IN-36	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-36 is a *tubulin* polymerization inhibitor (IC₅₀: 2.8 μΜ). Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-36 can be used in the research of cancers, such as lymphomas .

HY-151398

Tubulin polymerization-IN-37	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-37 is a *tubulin* polymerization inhibitor (IC₅₀: 2.3 μΜ). Tubulin polymerization-IN-37 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-37 can be used in the research of cancers, such as lymphomas .

HY-151982

Tubulin polymerization-IN-39	Microtubule/Tubulin	Cardiovascular Disease Cancer
Tubulin polymerization-IN-39 is a tubulin polymerization inhibitor (IC₅₀: 4.9 μM). Tubulin polymerization-IN-39 occupies the colchicine-binding site. Tubulin polymerization-IN-39 inhibits cancer cell proliferation .

HY-146362

Tubulin polymerization-IN-17	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-17 (compound 23g) is a potent inhibitor of *tubulin* polymerization. Tubulin polymerization-IN-17 exhibits tubulin depolymerization and induced cell apoptosis and inhibits migration. Tubulin polymerization-IN-17 has the potential for the research of cancer diseases .

HY-152143

Tubulin polymerization-IN-41	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-41 is a potent **tubulin polymerization** inhibitor with the IC₅₀ of 2.61 μM. Tubulin polymerization-IN-41 targets the Colchicine-binding site of tubulin. Tubulin polymerization-IN-41 has anticancer effects .

HY-156737

Tubulin polymerization-IN-49	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-49 (compound 12d) is a potent **tubulin polymerization** inhibitor. Tubulin polymerization-IN-49 bound to colchicine site on tubulin and inhibited tubulin polymerization. Tubulin polymerization-IN-49 induces cell cycle arrest at G2/M phase and apoptosis. Tubulin polymerization-IN-49 has anticancer active and prevents tumor generation, inhibits tumor proliferation and angiogenesis .

HY-157543

Tubulin polymerization-IN-59	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-59 ((R)-9k) is a potent inhibitor of colchicine binding site inhibitor (CBSI). Tubulin polymerization-IN-59 inhibits tubulin polymerization .

HY-101989

Tubulin polymerization-IN-24	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-24 (compound HMBA) is a potent **tubulin polymerization** inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly .

HY-146310

Tubulin polymerization-IN-15	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-15 (compound 4) is a potent inhibitor of *tubulin* polymerization. Tubulin polymerization-IN-15 has the potential for the research of cancer diseases .

HY-143446

Tubulin polymerization-IN-7	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-7 (compound 5) is a potent inhibitor of *tubulin* polymerization. Tubulin polymerization-IN-7 has the potential for the research of cancer diseases .

HY-168565

Tubulin polymerization-IN-70	Apoptosis Microtubule/Tubulin Reactive Oxygen Species	Cancer
Tubulin polymerization-IN-70 (compound Q19) is a potent **tubulin polymerization** inhibitor. Tubulin polymerization-IN-70 shows antiproliferative activity. Tubulin polymerization-IN-70 target the colchicine binding site of tubulin and inhibited tubulin polymerization. Tubulin polymerization-IN-70 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-70 induces mitochondrial membrane potential decrease and increases the levels of reactive oxygen species (ROS). Tubulin polymerization-IN-70 shows antiangiogenic and anticancer activity .

HY-163664

Tubulin polymerization-IN-63	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-63 (compound 6) is a tubulin polymerization inhibitor. The IC₅₀ value of Tubulin polymerization-IN-63 for MES-SA cells is 0.29 μM. Tubulin polymerization-IN-63 can be used in cancer research .

HY-146377

Tubulin polymerization-IN-19	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-19 (compound 4) is a potent inhibitor of *tubulin* polymerization. Tubulin polymerization-IN-20 has the potential for the research of breast cancers and chemoresistant colon cancers .

HY-146378

Tubulin polymerization-IN-20	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-20 (compound 11) is a potent inhibitor of *tubulin* polymerization. Tubulin polymerization-IN-20 has the potential for the research of breast cancers and chemoresistant colon cancers .

HY-146376

Tubulin polymerization-IN-18	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-18 (compound 8) is a potent inhibitor of *tubulin* polymerization. Tubulin polymerization-IN-18 has the potential for the research of breast cancers and chemoresistant colon cancers .

HY-146863

Tubulin polymerization-IN-10	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-10 is a potent **tubulin polymerization** inhibitor with an IC₅₀ of 4.25±0.75 μM. Tubulin polymerization-IN-10 has anti-tumor effects .

HY-147896

Tubulin polymerization-IN-29	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-29 (compound 6g) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-29 exhibits potent antiproliferative activity. Tubulin polymerization-IN-29 can induce HeLa cells arrest in G2/M phase .

HY-155963

Tubulin polymerization-IN-48	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-48 (Compound 4k) is a **tubulin polymerization** inhibitor. Tubulin polymerization-IN-48 has a moderate effect on disruption of the microtubule network. Tubulin polymerization-IN-48 inhibits neuroblastoma cancer cell proliferation, with IC₅₀s of 79 and 165 nM for Chp-134 and Kelly cell line .

HY-146164

Tubulin polymerization-IN-21	Microtubule/Tubulin	Metabolic Disease Cancer
Tubulin polymerization-IN-21 (compound 9a) is a **tubulin polymerization** inhibitor. Tubulin polymerization-IN-21 exhibits anti-cancer activity through disrupting cellular integrity and affecting glucose metabolism .

HY-146505

Tubulin polymerization-IN-6	Microtubule/Tubulin Apoptosis Reactive Oxygen Species	Cancer
Tubulin polymerization-IN-6 (compound 5f) is a potent **tubulin polymerization** inhibitor, with an IC₅₀ of 1.09 μM. Tubulin polymerization-IN-6 inhibits cell migration and tube formation and contributes to the anti-angiogenesis. Tubulin polymerization-IN-6 can greatly inhibit tumor growth on HT29 xenograft Balb/c nude mice .

HY-145868

Tubulin polymerization-IN-3	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-3 (compound 4c) is a potent **tubulin polymerization** inhibitor, with an IC₅₀ of 3.84 µM. Tubulin polymerization-IN-3 can induce apoptosis in colon cancer cells .

HY-147981

Tubulin polymerization-IN-31	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-31 (Compound 4c) is a **tubulin polymerization** inhibitor with an IC₅₀ of 3.64 μM. Tubulin polymerization-IN-31 induces cancer cell apoptosis and shows antitumor activity .

HY-144786

Tubulin polymerization-IN-4	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-4 is a potent **tubulin polymerization** inhibitor with IC₅₀ value of 4.6 μM. Tubulin polymerization-IN-4 can disrupt tubulin polymerization and vasculature, arrest the cell cycle at the G2/M phase, induce apoptosis, and suppress clonogenesis and migration in HeLa cells. Tubulin polymerization-IN-4 can be used for researching cervical cancer .

HY-147848

Tubulin polymerization-IN-27	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-27 (compound 5j) is a **tubulin polymerization** inhibitor. Tubulin polymerization-IN-27 can arrest cell cycle at G2/M phase and induce apoptosis .

HY-147824

Tubulin polymerization-IN-22	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-22 is a **tubulin polymerization** inhibitor with an IC₅₀ of 8.1 μM. Tubulin polymerization-IN-22 arrests cell cycle at G2/M phase and induces apoptosis .

HY-143447

Tubulin polymerization-IN-8	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-8 (compound IIc) is a potent inhibitor of *tubulin* polymerization. Tubulin polymerization-IN-8 concentration-dependently causes cell cycle arrest at the G2/M phase in HCT116 tumor cells, and displays a significant inhibition of tubulin polymerization with an IC₅₀ value of 12.7 μM. Tubulin polymerization-IN-8 has the potential for the research of cancer diseases ^{[ 1]}.

HY-155962

Tubulin polymerization-IN-47	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-47 (Compound 4h) is a *tubulin* polymerization inhibitor and mitotic inhibitor. Tubulin polymerization-IN-47 inhibits neuroblastoma cancer cell proliferation, with IC₅₀s of 7 and 12 nM for Chp-134 and Kelly cell line .

HY-146211

Tubulin polymerization-IN-14	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-14 (Compound 20a) is a **tubulin polymerization** inhibitor with an IC₅₀ of 3.15 μM. Tubulin polymerization-IN-14 shows potent anti-vascular and anticancer activities, induces cancer cell apoptosis .

HY-156271

Tubulin polymerization-IN-52	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-52 (compound SC23) is a potent *tubulin* polymerization inhibitor, with an IC₅₀ of 2.9 μM .

HY-161763

Tubulin polymerization-IN-65	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-65 is a tubulin polymerisation inhibitor with a broad spectrum cytotoxic. Tubulin polymerization-IN-65 induces G2 + M cell cycle arrest .

HY-155043

Tubulin polymerization-IN-42	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-42 (compound 10j), an indole-substituted furanone, is an inhibitor of tubulin polymerization with anti-cancer activity .

HY-163983

Tubulin polymerization-IN-68	Microtubule/Tubulin Apoptosis PARP Caspase	Cancer
Tubulin polymerization-IN-68 (compound 32) is a *tubulin* inhibitor that can inhibit tubulin polymerization and destroy the cellular microtubule network. Tubulin polymerization-IN-68 can upregulate the expression of PARP-1 and caspase-3 and induce cell apoptosis, and has anticancer activity. Tubulin polymerization-IN-68 can effectively inhibit HepG2 (IC₅₀=93 nM) and significantly inhibit the growth of HepG2 xenograft tumors in nude mice by oral administration .

HY-161338

Tubulin polymerization-IN-61	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-61 (Compound 9a) is a *tubulin* polymerization inhibitor. Tubulin polymerization-IN-61 destroys the microtubule skeleton, blocks the cell cycle in G2/M phase, induces Apoptosis, and inhibits cancer cell migration and colony formation. Tubulin polymerization-IN-61 shows antitumor activity in vivo against 4T1 xenograft model .

HY-146817

Tubulin polymerization-IN-11	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-11 is a potent **tubulin polymerization** inhibitor with an IC₅₀ value of 3.4 µM. Tubulin polymerization-IN-11 shows antiproliferative activity. Tubulin polymerization-IN-11 induces Apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-11 decreases the expression of cyclin B1, p-cdc2, and Bcl-2 protein levels and increases the expression of cleaved PARP .

HY-162264

Tubulin polymerization/V-ATPase-IN-1	Microtubule/Tubulin Proton Pump Apoptosis	Inflammation/Immunology Cancer
Tubulin polymerization/V-ATPase-IN-1 (compound F10) is a **Tubulin polymerization/V-ATPase** inhibitor. Tubulin polymerization/V-ATPase-IN-1 shows robust antiproliferation activity against four human cancer cell lines, and exerts antiproliferative activity by inhibiting tubulin and V-ATPase. Tubulin polymerization/V-ATPase-IN-1 induces immunogenic cell death in addition to apoptosis, and inhibits tumor growth in an RM-1 homograft model with enhanced T lymphocyte infiltration .

HY-146818

Tubulin polymerization-IN-12	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-12 is a tubulin polymerization inhibitor (IC₅₀=0.75 μM). Tubulin polymerization-IN-12 arrests cell cycle at G2/M phase, and exhibits cytotoxicity against cancer cells .

HY-147947

Tubulin polymerization-IN-30	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-30 (compound 6e) is a potent **Tubulin polymerization** inhibitor. Tubulin polymerization-IN-30 is a colchicine binding site inhibitor. Tubulin polymerization-IN-30 can disrupt intracellular microtubule organization, arrest cell cycle at the G2/M phase. Tubulin polymerization-IN-30 exhibits the high potency against the cancer cell lines including SGC-7901, A549 and HeLa, with IC₅₀ values of 2.16, 2.21, and 0.403 μM .

HY-163356

Tubulin polymerization-IN-60	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-60 (BF3) is a **tubulin polymerization** inhibitor with anticancer activity. Tubulin polymerization-IN-60 (BF3) belongs to the colchicine binding site inhibitors (CBSIs) and disturbs cell cycle progression leading to G2/M arrest and apoptosis .

Cat. No.	Product Name	Type

HY-15162G

Monomethyl auristatin E (GMP) MMAE (GMP); SGD-1010 (GMP); Vedotin (GMP)	Fluorescent Dye
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .

HY-15582G

Auristatin E (GMP)	Fluorescent Dye
Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor .

HY-100374G

Val-Cit-PAB-MMAE (GMP)	Fluorescent Dye
Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

HY-78931G

Boc-Dap-NE (GMP)	Fluorescent Dye
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-15579G

MMAF (GMP) Monomethylauristatin F (GMP)	Fluorescent Dye
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent **tubulin polymerization** inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .

HY-15579BG

MMAF sodium (GMP) Monomethylauristatin F sodium (GMP)	Fluorescent Dye
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent **tubulin polymerization** inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

HY-15578G

McMMAF (GMP) Maleimidocaproyl monomethylauristatin F (GMP)	Fluorescent Dye
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

Cat. No.	Product Name	Type

HY-15162G

Monomethyl auristatin E (GMP) MMAE (GMP); SGD-1010 (GMP); Vedotin (GMP)	Biochemical Assay Reagents
Monomethyl auristatin E (MMAE) (GMP) is Monomethyl auristatin E (HY-15162) produced by using GMP guidelines. Monomethyl auristatin E is a tubulin polymerization inhibitor .

HY-15582G

Auristatin E (GMP)	Biochemical Assay Reagents
Auristatin E (GMP) is Auristatin E (HY-15582) produced by using GMP guidelines. Auristatin E is a tubulin polymerization inhibitor .

HY-100374G

Val-Cit-PAB-MMAE (GMP)	Biochemical Assay Reagents
Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

HY-78931G

Boc-Dap-NE (GMP)	Biochemical Assay Reagents
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-15579G

MMAF (GMP) Monomethylauristatin F (GMP)	Biochemical Assay Reagents
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent **tubulin polymerization** inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .

HY-15579BG

MMAF sodium (GMP) Monomethylauristatin F sodium (GMP)	Biochemical Assay Reagents
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent **tubulin polymerization** inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

HY-15578G

McMMAF (GMP) Maleimidocaproyl monomethylauristatin F (GMP)	Biochemical Assay Reagents
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

Cat. No.	Product Name	Target	Research Area

HY-15580

Dolastatin 10 DLS 10; NSC 376128	Microtubule/Tubulin ADC Cytotoxin	Cancer
Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits *tubulin* polymerization.

HY-P10589

Phomopsinamine A	Microtubule/Tubulin	Cancer
Phomopsinamine A is a derivative of Phomopsin A (HY-N6793). Phomopsinamine A is an inhibitor for **tubulin polymerization with IC₅₀** of 0.53 μM. Phomopsinamine A inhibits the binding of Vinblastine (HY-13780) to tubulin (IC₅₀ =0.56 μM), promotes the the binding of Colchicine (HY-16569) to tubulin (IC₅₀ =0.32 μM) .

Cat. No.	Product Name	Target	Research Area

HY-164153

ADC Control Human IgG1-vcMMAE	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
ADC Control Human IgG1-vcMMAE is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAE and can inhibit *tubulin* polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is vcMMAE (HY-15575) .

HY-164154

ADC Control Human IgG1-vcMMAF	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
ADC Control Human IgG1-vcMMAF is a humanized monoclonal antibody that is an isotype control of ADC human IgG1-vcMMAF and can inhibit *tubulin* polymerization. The antibody portion is Human IgG1 kappa, Isotype Control (HY-P99001), and the drug-linker conjugate for ADC is MC-Val-Cit-PAB-MMAF (vcMMAF; HY-112786) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15580

Dolastatin 10 DLS 10; NSC 376128	Structural Classification Natural Products Classification of Application Fields Source classification Marine natural products Other marine organisms Disease Research Fields Cancer	Microtubule/Tubulin ADC Cytotoxin
Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits *tubulin* polymerization.

HY-13503

Epothilone A Epo A	Structural Classification Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis
Epothilone A is a competitive inhibitor of the binding of [ ³H] paclitaxel to *tubulin* polymers, with a K_i of 0.6-1.4 μM.

HY-N2415

Podophyllotoxone 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Lignans Dysosma versipellis (Hance) M. Cheng ex Ying Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Microtubule/Tubulin
Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the *tubulin* polymerization .

HY-N0282

Demecolcine 3 Publications Verification	Alkaloids Structural Classification other families Classification of Application Fields Other Alkaloids Source classification Plants Inflammation/Immunology Disease Research Fields	Microtubule/Tubulin Apoptosis
Demecolcine is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of *tubulin* polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-19474

Maytansinol Ansamitocin P-0	Alkaloids Microorganisms Other Alkaloids Source classification Disease Research Fields Cancer	Microtubule/Tubulin ADC Cytotoxin Apoptosis
Maytansinol (Ansamitocin P-0) is a derivative of Maytansine. Maytansinol can inhibit *tubulin* polymerization and induce apoptosis. Maytansinol has antitumor activity. Maytansinol can be used in cancer drug research .

HY-N9842

Violanone	Infection Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Isoflavones	Microtubule/Tubulin
Violanone, an isoflavanone compound, can inhibit tubulin polymerization. Violanone also exhibits larvicidal activity against A. aegypti .

HY-N3950

Glochidiol	Triterpenes Structural Classification Phyllanthaceae Glochidion eriocarpum Champ. ex Benth. Terpenoids Source classification Plants	Microtubule/Tubulin
Glochidiol is an orally active **tubulin polymerization** inhibitor with an IC₅₀ of 2.76 μM. Glochidiol shows anti-cancer activity .

HY-N8287

Oxaline	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	Microtubule/Tubulin
Oxaline is a fungal alkaloid that can be isolated from Penicillium oxalicum. Oxaline inhibits tubulin polymerization, resulting in cell cycle arrest at the M phase .

HY-N8745

α-Peltatin	Structural Classification Podophyllum peltatum L. Source classification Lignans Phenylpropanoids Plants Berberidaceae	Fungal
α-Peltatin is an aryl lignan. α-Peltatin has anticancer and antifungal activity. α-Peltatin inhibits DNA topoisomerase and tubulin polymerization .

HY-13503R

Epothilone A (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Disease Research Anticancer	Microtubule/Tubulin Apoptosis
Epothilone A (Standard) is the analytical standard of Epothilone A. This product is intended for research and analytical applications. Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers, with a Ki of 0.6-1.4 μM.

HY-N0282R

Colcemid (Standard)	Alkaloids Structural Classification other families Other Alkaloids Source classification Plants	Microtubule/Tubulin Apoptosis
Colcemid (Standard) is the analytical standard of Colcemid. This product is intended for research and analytical applications. Colcemid (Demecolcine) is a potent mitotic inhibitor with an IC₅₀ value of 2.4 μM for inhibition of *tubulin* polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research .

HY-N1391

10-Deacetyltaxol 10-Deacetylpaclitaxel	Structural Classification Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus wallichiana Zucc. Cancer	Microtubule/Tubulin
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of *tubulin* and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-N1243

Tubulysin B	Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	Microtubule/Tubulin Apoptosis
Tubulysin B is a highly cytotoxic peptide and potent microtubule destabilizing agents isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin B has IC₅₀ values in the picomolar range against many cancer cell lines, including those with multidrug resistant properties .Tubulysin B is a cytotoxic activity tubulysin which inhibits *tubulin* polymerization and leads to cell cycle arrest and apoptosis .

HY-16569

Colchicine Maximum Cited Publications 32 Publications Verification	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Disease Research Fields Cancer	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine, an orally active alkaloid, is a potent *tubulin* inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-N2348

Tubulysin D	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin D is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin D can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin D displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin D inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2346

Tubulysin E	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin E is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin E can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin E displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin E inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N2347

Tubulysin C	Structural Classification Natural Products Monophenols Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin C is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin C can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin C displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin C inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7049

Tubulysin F	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin F is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin F can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin F displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin F inhibits microtubule/Tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7050

Tubulysin G	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin G is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin G can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin G displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin G inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7051

Tubulysin H	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin H is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin H can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin H displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin H inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7052

Tubulysin I	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N7053

Tubulysin M	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	ADC Cytotoxin Microtubule/Tubulin
Tubulysin M is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin M can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin M displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC₅₀ values in the low nanomolar range. Tubulysin M inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis .

HY-N1391R

10-Deacetyltaxol (Standard)	Structural Classification Terpenoids Taxaceae Source classification Diterpenoids Plants Taxus wallichiana Zucc.	Microtubule/Tubulin
10-Deacetyltaxol (Standard) is the analytical standard of 10-Deacetyltaxol. This product is intended for research and analytical applications. 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc . 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro . 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines .

HY-16569R

Colchicine (Standard)	Structural Classification Natural Products other families Source classification Plants	Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

Cat. No.	Product Name	Chemical Structure

HY-116852S

Thiocolchicine-d3

Thiocolchicine-d₃ is deuterium labeled Thiocolchicine. Thiocolchicine, a derivative modified in the C Ring of Colchicine (HY-16569) with enhanced biological properties. Thiocolchicine is a potent inhibitor of tubulin polymerization (IC50=2.5 µM) and competitively binds to tubulin with a Ki of 0.7 µM. Thiocolchicine induces cell apoptosis[1][2]. Thiocolchicine can be used as an ADC cytotoxin in ADC technology.

HY-16569S

Colchicine-d6
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

HY-16569S1

Colchicine-d3
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM[1][2][3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs)[4].

Cat. No.	Product Name		Classification

HY-136314

DBCO-PEG4-VC-PAB-MMAE		DBCO
DBCO-PEG4-VC-PAB-MMAE consists a ADC linker (DBCO-PEG4-VC-PAB) and a tubulin polymerization inhibitor MMAE (HY-15162). DBCO-PEG4-VC-PAB-MMAE can be used in the synthesis of antibody-agent conjugates (ADCs). MMAE is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. DBCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-133492

DBCO-PEG4-MMAF		DBCO
DBCO-PEG4-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the tubulin polymerization inhibitor, MMAF, linked via the cleavable linker DBCO-PEG4. DBCO-PEG4-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-130990

DBCO-PEG4-Val-Cit-PAB-MMAF		DBCO
DBCO-PEG4-Val-Cit-PAB-MMAF consists a cleavable 4 unit PEG ADC linker (DBCO-PEG4-Val-Cit-PAB) and a potent tubulin polymerization inhibitor (MMAF). DBCO-PEG4-Val-Cit-PAB-MMAF can be used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-PEG4-Val-Cit-PAB-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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