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behaviors

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257

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5

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1

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6

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63

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31

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153015
    AAZ-A 154

    		5-HT Receptor Neurological Disease
    AAZ-A 154 is a selective, competitive and non-hallucinogenic 5-HT2AR antagonist. AAZ-A 154 can promote neuronal growth and produce long-lasting beneficial behavioral effects in rodents .
    AAZ-A 154
  • HY-103511
    TCS1105

    		GABA Receptor Neurological Disease
    TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion .
    TCS1105
  • HY-107718
    Midafotel

    SDZ-EAA 494

    		 iGluR Neurological Disease
    Midafotel (SDZ-EAA 494) is a potent and comprtitive NMDA antagonist with an ED50 value of 39 nM. Midafotel causes intense stereotyped behaviors. Midafotel shows neuroprotective effects .
    Midafotel
  • HY-153015B
    AAZ-A 154 hydrochloride

    		5-HT Receptor Neurological Disease
    AAZ-A 154 hydrochloride is a selective, competitive and non-hallucinogenic 5-HT2AR antagonist. AAZ-A 154 hydrochloride can promote neuronal growth and produce long-lasting beneficial behavioral effects in rodents .
    AAZ-A 154 hydrochloride
  • HY-153015D
    AAZ-A 154 mesylate

    		5-HT Receptor Neurological Disease
    AAZ-A 154 mesylate is a selective, competitive and non-hallucinogenic 5-HT2AR antagonist. AAZ-A 154 mesylate can promote neuronal growth and produce long-lasting beneficial behavioral effects in rodents .
    AAZ-A 154 mesylate
  • HY-153015A
    AAZ-A 154 hydrobromide

    		5-HT Receptor Neurological Disease
    AAZ-A 154 hydrobromide is a selective, competitive and non-hallucinogenic 5-HT2AR antagonist. AAZ-A 154 hydrobromide can promote neuronal growth and produce long-lasting beneficial behavioral effects in rodents .
    AAZ-A 154 hydrobromide
  • HY-153015C
    AAZ-A 154 benzoate

    		5-HT Receptor Neurological Disease
    AAZ-A 154 benzoate is a selective, competitive and non-hallucinogenic 5-HT2AR antagonist. AAZ-A 154 benzoate can promote neuronal growth and produce long-lasting beneficial behavioral effects in rodents .
    AAZ-A 154 benzoate
  • HY-131479
    Threo-dihydrobupropion hydrochloride

    		Drug Metabolite Neurological Disease
    Threo-dihydrobupropion hydrochloride is a primary metabolite of Bupropion. Threo-dihydrobupropion hydrochloride can be used for the research of the depression, behavioral, and biochemistry .
    Threo-dihydrobupropion hydrochloride
  • HY-P2014
    (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin

    		Oxytocin Receptor Neurological Disease
    (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin is an oxytocin antagonist and can be used for the research of sexual behavior .
    (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin
  • HY-121650A
    ADTN hydrobromide

    		Dopamine Receptor Neurological Disease
    ADTN hydrobromide is a long-acting dopamine agonist. ADTN hydrobromide significantly decreases the behavioral visual threshold of DA-IPC-depleted zebrafish .
    ADTN hydrobromide
  • HY-138639
    PW0787

    		GPR52 Neurological Disease
    PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC50=135 nM). PW0787 suppresses psychostimulant behavior .
    PW0787
  • HY-44134
    Dimethyl 2-oxoglutarate

    Dimethyl α-ketoglutarate

    		 Endogenous Metabolite Others
    Dimethyl 2-oxoglutarate serves as a crucial intermediate in the Krebs cycle and an essential nitrogen carrier in metabolic pathways during biological processes. The electrochemical behavior of Dimethyl 2-oxoglutarate can be investigated using cyclic voltammetry, square wave voltammetry, and differential pulse voltammetry with a glassy carbon electrode .
    Dimethyl 2-oxoglutarate
  • HY-133985
    7(Z)-Pentacosene

    		Others Others Neurological Disease
    7(Z)-Pentacosene is an aggregation pheromone of the European earwig (Forficula auricularia). 7(Z)-Pentacosene can be used in the study of insect behavior and neurobiology .
    7(Z)-Pentacosene
  • HY-168021
    MAO-A/SERT-IN-1

    		Monoamine Oxidase Serotonin Transporter Neurological Disease
    MAO-A/SERT-IN-1 is an inhibitor of MAO-A/serotonin transporter (SERT). MAO-A/SERT-IN-1 can reduce SERT-mediated reuptake of 5-HT and has neuroprotective effects in cell inhibition models. MAO-A/SERT-IN-1 can improve depressive behavior in zebrafish and mice .
    MAO-A/SERT-IN-1
  • HY-100998
    Metaphit

    		Others Neurological Disease
    Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates . Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms .
    Metaphit
  • HY-100719
    BRD-6929

    		HDAC HIV Infection Cardiovascular Disease
    BRD-6929 is a?potent, selective brain-penetrant inhibitor of class I histone deacetylase HDAC1 and HDAC2 inhibitor with IC50 of 1 nM and 8 nM, respectively. BRD-6929 shows high-affinity to HDAC1 and HDAC2 with?Ki?of 0.2 and 1.5 nM, respectively. BRD-6929 can be used for mood-related behavioral model research .
    BRD-6929
  • HY-18678
    Bremelanotide

    PT-141

    		 Melanocortin Receptor Endocrinology
    Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders .
    Bremelanotide
  • HY-N12715
    Valerena-4,7(11)-diene

    		Others Neurological Disease
    Valerena-4,7(11)-diene is a tranquilizer. Valerena-4,7(11)-diene suppresses stress-induced excitatory behaviors. Valerena-4,7(11)-diene is expressed via olfactory stimulation and pulmonary absorption .
    Valerena-4,7(11)-diene
  • HY-131587
    Integerrimine N-oxide

    		Others Others
    Integerrimine N-oxide, the main pyrrolizidine alkaloid found in the butanolic residue (BR) of Senecio brasiliensis. Prenatal exposure to integerrimine N-oxide induces maternal toxicity, impairment of maternal care and delays in physical and behavioral development of the offspring .
    Integerrimine N-oxide
  • HY-10174
    PD184161
    1 Publications Verification

    		 MEK Apoptosis Neurological Disease Cancer
    PD184161 is an orally active MEK inhibitor. PD184161 inhibits MEK activity (IC50=10-100 nM) in a time- and concentration-dependent manner. PD184161 inhibits cell proliferation and induces apoptosis. PD184161 produces depressive-like behavior .
    PD184161
  • HY-131181
    LEI-401
    2 Publications Verification

    		 Phospholipase Neurological Disease
    LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice .
    LEI-401
  • HY-119918
    Cycrimine

    		mAChR Neurological Disease
    Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder .
    Cycrimine
  • HY-P1216
    HS014

    		Melanocortin Receptor Neurological Disease
    HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. HS014 modulates the behavioral effects of morphine in mice. HS014 increases food intake in free-feeding rats .
    HS014
  • HY-17571
    Oxytocin
    10+ Cited Publications

    α-Hypophamine; Oxytocic hormone

    		 Oxytocin Receptor Endogenous Metabolite Endocrinology Cancer
    Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .
    Oxytocin
  • HY-17571A
    Oxytocin acetate
    10+ Cited Publications

    α-Hypophamine acetate; Oxytocic hormone acetate

    		 Oxytocin Receptor Endogenous Metabolite Endocrinology Cancer
    Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .
    Oxytocin acetate
  • HY-145196
    RTICBM-189

    		Cannabinoid Receptor Neurological Disease
    RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca 2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the addictive agent-seeking behavior in rats .
    RTICBM-189
  • HY-145153
    S-777469

    		Cannabinoid Receptor Neurological Disease
    S-777469 is a selective and orally available cannabinoid type 2 receptor (CB2) agonist with a Ki of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism .
    S-777469
  • HY-12700
    RO5256390
    2 Publications Verification

    		 Trace Amine-associated Receptor (TAAR) Neurological Disease
    RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine (HY-14541). RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176)-induced TNF secretion in mouse bone marrow-derived macrophages .
    RO5256390
  • HY-P5765
    Galanin (1-13)-spantide I

    		Neuropeptide Y Receptor Neurological Disease
    Galanin (1-13)-spantide I is a chimeric peptide composed of the N-terminal fragment of galanin (amino acids 1-13) and spantide, a known substance P receptor antagonist. Galanin (1-13)-spantide I has a high affinity for spinal galanin receptor (Kd=1.16 nM). Galanin (1-13)-spantide I can be used to study the effects of galanin on feeding behavior .
    Galanin (1-13)-spantide I
  • HY-P3035
    Corazonin

    		G Protein-coupled Receptor Kinase (GRK) Neurological Disease
    Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects, serves a central regulator of caste identity and behavior in social insects. Corazonin is also preferentially expressed in workers and/or foragers from other social insect species .
    Corazonin
  • HY-103377
    Antalarmin hydrochloride
    2 Publications Verification

    		 CRFR Inflammation/Immunology Endocrinology
    Antalarmin (hydrochloride) is an oral active non-peptide corticotropin-releasing hormone receptor 1 (CRHR1) antagonist with a Ki of 1 nM. Antalarmin hydrochloride suppresses CRH-induced ACTH secretion and blocks CRH and novelty induced anxiety-like behavior in animal models. Antalarmin hydrochloride produces anti-inflammatory effects in arthritis models, and suppresses stress-induced gastric ulceration related to irritable bowel syndrome .
    Antalarmin hydrochloride
  • HY-17571AR
    Oxytocin acetate (Standard)

    		Oxytocin Receptor Endogenous Metabolite Endocrinology Cancer
    Oxytocin (acetate) (Standard) is the analytical standard of Oxytocin (acetate). This product is intended for research and analytical applications. Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .
    Oxytocin acetate (Standard)
  • HY-103111
    MMPIP hydrochloride

    		mGluR Neurological Disease
    MMPIP hydrochloride is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (KB values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice .
    MMPIP hydrochloride
  • HY-107503
    MMPIP

    		mGluR Neurological Disease
    MMPIP is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (KB values 24 -30 nM). MMPIP acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP alleviates pain and normalizes affective and cognitive behavior in neuropathic mice .
    MMPIP
  • HY-108519
    AS1892802

    		ROCK Neurological Disease
    AS1892802 is a potent, orally active, and highly selective inhibitor of ROCK. The onset of antinociceptive effect of AS1892802 is as fast as those of Tramadol and Diclofenac. AS1892802 did not induce gastric irritation or abnormal behavior. AS1892802 is an attractive analgesic profile for the research of severe osteoarthritis pain .
    AS1892802
  • HY-106224
    Orexin A (human, rat, mouse)
    5+ Cited Publications

    Hypocretin-1 (human, rat, mouse)

    		 Orexin Receptor (OX Receptor) Neurological Disease
    Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)), a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .
    Orexin A (human, rat, mouse)
  • HY-106224A
    Orexin A (human, rat, mouse) (TFA)
    5+ Cited Publications

    Hypocretin-1 (human, rat, mouse) (TFA)

    		 Orexin Receptor (OX Receptor) Neurological Disease
    Orexin A (human, rat, mouse) (Hypocretin-1 (human, rat, mouse)) TFA, a 33 amino acid excitatory neuropeptide, orchestrates diverse central and peripheral processes. Orexin A (human, rat, mouse) TFA binds and activates two types of G protein-coupled receptors, the orexin-1 receptor (OX1R) and the orexin-2 receptor (OX2R). Orexin A (human, rat, mouse) TFA has a role in the regulation of feeding behavior. Orexin A (human, rat, mouse) TFA is an effective anti-nociceptive and anti-hyperalgesic agent in mice and rats .
    Orexin A (human, rat, mouse) (TFA)
  • HY-P3801
    [Glp5,(Me)Phe8,Sar9] Substance P (5-11)

    DiMe-C7

    		 Neurokinin Receptor Others Neurological Disease Metabolic Disease
    [Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats .
    [Glp5,(Me)Phe8,Sar9] Substance P (5-11)
  • HY-P10290
    Neuropeptide Y (human) (free acid)

    		Neuropeptide Y Receptor Neurological Disease
    Neuropeptide Y (human) free acid upregulates the adhesiveness of human endothelial cells for leukocytes. Neuropeptide Y belongs to the pancreatic polypeptide family, plays an important role in circadian rhythms, neurogenesis, and neuroprotection, nociception, feeding behavior, energy regulation, neuronal excitability, emotion, cognition, and stress response .
    Neuropeptide Y (human) (free acid)
  • HY-12711
    2-Methoxyidazoxan

    RX821002

    		 Others Others
    2-Methoxyidazoxan (RX821002) is a compound that modulates play behavior and can increase play behavior in F344 rats, suggesting that it may modulate play behavior by acting on NEα-2 receptors.
    2-Methoxyidazoxan
  • HY-W634602
    (R)-RO5263397

    		Others Others
    (R)-RO5263397 is a TAAR 1 agonist that demonstrates efficacy in reducing cocaine-mediated behaviors, including cocaine-induced behavioral sensitization, cue- and cocaine prime-induced reinstatement of cocaine-seeking behavior, and the expression of conditioned place preference.
    (R)-RO5263397
  • HY-W115718
    Cuprizone
    1 Publications Verification

    		 Dopamine β-hydroxylase Neurological Disease
    Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) .
    Cuprizone
  • HY-W020795
    Hexadecyl β-D-maltoside

    		Biochemical Assay Reagents Others
    Hexadecyl β-D-maltoside is the anomer of Hexadecyl α-d-maltoside. Hexadecyl β-D-maltoside is different from Hexadecyl α-d-maltoside, showing non-Newtonian behavior, including thixotropic behavior, shear-thinning, and viscoelastic behavior .
    Hexadecyl β-D-maltoside
  • HY-143880
    MRGPRX1 agonist 4

    		Mas-related G-protein-coupled Receptor (MRGPR) Neurological Disease
    MRGPRX1 agonist 4 (compound 1t) is a potent and orally active Mas-related G protein-coupled receptor X1 (MRGPRX1) positive allosteric modulator with an EC50 value of 0.1 μM. MRGPRX1 agonist 4 has good metabolic stability and oral bioavailability. MRGPRX1 agonist 4 can reduce behavioral heat hypersensitivity in a neuropathic pain model humanized MRGPRX1 mice. MRGPRX1 agonist 4 can be used for researching neuropathic pain .
    MRGPRX1 agonist 4
  • HY-131879
    NS383

    		Sodium Channel Neurological Disease
    NS383 is a potent and uniquely selective inhibitor of rat ASICs containing 1a and/or 3 subunits. NS383 inhibits H(+)-activated currents recorded from rat homomeric ASIC1a, ASIC3, and heteromeric ASIC1a+3 with IC50 values ranging from 0.61 to 2.2 μM. NS383 is well tolerated and capable of reversing pathological painlike behaviors, presumably via peripheral actions, but possibly also via actions within central pain circuits .
    NS383
  • HY-B1232
    Metyrapone
    5 Publications Verification

    Su-4885

    		 Endogenous Metabolite Cytochrome P450 Autophagy Neurological Disease Metabolic Disease Endocrinology Cancer
    Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .
    Metyrapone
  • HY-B1232A
    Metyrapone Tartrate

    Su-4885 Tartrate

    		 Endogenous Metabolite Cytochrome P450 Autophagy mTOR Neurological Disease Endocrinology
    Metyrapone (Su-4885) Tartrate is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone Tartrate inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone Tartrate increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone Tartrate can be used for researching Cushing's syndrome and depression .
    Metyrapone Tartrate
  • HY-B1232R
    Metyrapone (Standard)

    		Endogenous Metabolite Cytochrome P450 Autophagy Neurological Disease Metabolic Disease Endocrinology Cancer
    Metyrapone (Standard) is the analytical standard of Metyrapone. This product is intended for research and analytical applications. Metyrapone (Su-4885) is a potent and orally active 11β-hydroxylase inhibitor and an autophagy activator, also inhibits the production of aldosterone. Metyrapone inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion. In addition, Metyrapone increases the efficiency of autophagic process via downregulation of mTOR pathway, and interacts with Pseudomonas putida cytochrome P-450. Metyrapone can be used for researching Cushing's syndrome and depression .
    Metyrapone (Standard)
  • HY-101080
    3'-Fluorobenzylspiperone maleate

    		Others Neurological Disease
    3'-Fluorobenzylspiperone maleate is a ligand for dopamine D2 receptors with activity in improving behavioral disorders. 3'-Fluorobenzylspiperone maleate showed better inhibitory effects than placebo, especially in reducing behavioral disorders .
    3'-Fluorobenzylspiperone maleate
  • HY-B1978
    Iprodione

    		Fungal Reactive Oxygen Species Androgen Receptor Infection
    Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats .
    Iprodione

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