Search Result
Results for "
chelator
" in MedChemExpress (MCE) Product Catalog:
176
Biochemical Assay Reagents
7
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-163200
-
|
|
Cuproptosis
|
Neurological Disease
|
|
Cu(I) chelator 1 (Compound LH2) is a chelator which targets the Cu(I) redox state. Cu(I) chelator 1 prevents ROS production .
|
-
-
- HY-20512
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N,N'-Dibenzylethylenediamine forms chelator with metals. N,N'-Dibenzylethylenediamine interacts with penicillin, forms a stable and tasteless salt of penicillin .
|
-
-
- HY-100168
-
|
|
Phospholipase
|
Others
|
|
BAPTA is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca 2+ release from intracellular stores or influx via Ca 2+-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
|
-
-
- HY-100168B
-
|
|
Phospholipase
|
Others
|
|
BAPTA tetrapotassium is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca 2+ release from intracellular stores or influx via Ca 2+-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
|
-
-
- HY-W283556
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
DO2A-tert-butyl ester is a bifunctional chelator (BFC) that can be used for the coupling of peptides and radionuclides. DO2A-tert-butyl ester can be used in the development of radionuclide imaging tracers .
|
-
-
- HY-D0861
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages .
|
-
-
- HY-158070
-
-
-
- HY-W250574
-
-
-
- HY-W088413A
-
|
|
Biochemical Assay Reagents
|
Cancer
|
|
DOTA-amide (dihydrate) is a Bifunctional Chelators (BFCs). DOTA-amide (dihydrate) binds to the Affibody molecule ZHER2:S1. Its complex binds specifically to HER2 and can be used to detect bone metastases, which are common in prostate cancer .
|
-
-
- HY-101672
-
|
FBS 0701
|
Ferroptosis
Parasite
|
Infection
|
|
Deferitazole (FBS 0701) is an orally active iron chelator. Deferitazole shows antimalarial activity and
Can be used for study of malaria .
|
-
-
- HY-114837
-
|
|
Ferroptosis
|
Cancer
|
|
HBED is a potent iron chelator. HBED can be used to study transfusional iron overload .
|
-
-
- HY-16739
-
-
-
- HY-D1641
-
|
|
Fluorescent Dye
|
Others
|
|
5,5'-Dimethyl BAPTA tetrapotassium is a water-soluble, extracellular membrane metal chelator with relative selectivity for calcium ions .
|
-
-
- HY-D0179
-
|
|
Biochemical Assay Reagents
|
Infection
Cardiovascular Disease
|
|
Cyclam is a metal chelator that forms metal complexes with a variety of metal ions. Cyclam metal complexes exhibits anti-HIV (such as AMD3100), nitric oxide (NO) releasing and scavenging (such as Zn(II)-Cyclam and Ru(II)-Cyclam), and SOD mimetic (such as Mn(III)-Cyclam and Zn(II)-Cyclam) activities .
|
-
-
- HY-100168A
-
|
|
Phospholipase
|
Others
|
|
BAPTA tetrasodium is a selective chelator for calcium. BAPTA tetrasodium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrasodium is widely used as an intracellular buffer for investigating the effects of Ca 2+ release from intracellular stores or influx via Ca 2+-permeable channels in the plasma membrane. BAPTA tetrasodium can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
|
-
-
- HY-W087027
-
-
-
- HY-131060
-
|
CN328
|
Ferroptosis
|
Others
|
|
CN128 hydrochloride (CN328) is an orally active and selective iron chelator. CN128 is used for the research of β-thalassemia .
|
-
-
- HY-138134
-
-
-
- HY-132927A
-
-
-
- HY-138269A
-
|
CHX-A''-DTPA-NCS hydrochloride
|
Biochemical Assay Reagents
|
Others
|
|
Barzuxetan (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. Barzuxetan (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-134418A
-
-
-
- HY-17359
-
|
ICL 670
|
Bacterial
Ferroptosis
|
Cancer
|
|
Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .
|
-
-
- HY-W088413
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DOTA-amideis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-amide can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W678394
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DOTA-Thiolis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-Thiol can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-158067
-
-
-
- HY-W782078
-
-
-
- HY-156035
-
-
-
- HY-158072
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DOTAM-NHS-esteris a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-NHS-ester can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W717743
-
-
-
- HY-W717830
-
|
|
Biochemical Assay Reagents
|
Others
|
|
CB-Cyclamis a bifunctional chelator (Bifunctional Chelator; BFC), which is a main chain Cyclen derivative of the macrocyclic ligand tetradecane. CB-Cyclam can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W717782
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bz-DTPA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. Bz-DTPA (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W726767
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DO2Ais a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DO2A can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W250844A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DO3A (trisodium)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DO3A (trisodium) can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W087027A
-
-
-
- HY-158077
-
|
(R)-tetraMe-DOTA
|
Biochemical Assay Reagents
|
Others
|
|
(R)-tetraMe-Tetraxetanis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. (R)-tetraMe-Tetraxetan can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W539916
-
-
-
- HY-W717779
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Aminobutyl-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. 4-Aminobutyl-DOTA can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-158071
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-SCN-Bn-HEHA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-SCN-Bn-HEHA (hydrochloride) can be used for drug conjugation.
|
-
-
- HY-128890A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DOTA-NHS-ester (hexafluorophosphate TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-NHS-ester (hexafluorophosphate TFA) can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-A0074
-
|
tetra-tBu-DTPA
|
Biochemical Assay Reagents
|
Others
|
|
DTPA-tetra (t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. DTPA-tetra (t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W782087A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-SCN-Bn-PCTA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-SCN-Bn-PCTA (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W782083
-
-
-
- HY-W717781A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-NH?-Bn-DTPA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-NH?-Bn-DTPA (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W782088A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-NH?-Bn-PCTA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-NH?-Bn-PCTA (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W802013
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DOTA-4AMPis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-4AMP can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-158068
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Maleimido-mono-amide-DTPA (TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. Maleimido-mono-amide-DTPA (TFA) can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-156038
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(S)-p-SCN-Bn-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. (S)-p-SCN-Bn-DOTA can be used for conjugation of peptides and radionuclides.
|
-
-
- HY-W749627
-
-
-
- HY-159181
-
-
-
- HY-159180
-
-
- HY-138123
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-Glu(OtBu)-OSu is used for synthesizing N3S chelators and double branched and triple branched carboxyl terminated polyethylene glycol reagents .
|
-
- HY-W451440
-
-
- HY-131673A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
(S)-p-SCN-Bn-TCMC (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. (S)-p-SCN-Bn-TCMC (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717800A
-
-
- HY-156138A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
CB-TE2A (tetrahydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC), which is a TETA derivative of the macrocyclic ligand tetradecane backbone. CB-TE2A (tetrahydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717833
-
-
- HY-128370
-
|
Ca-DTPA trisodium salt hydrate
|
CMV
|
Infection
|
|
Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) is a metal chelator and a useful antidote (such as acute cadmium intoxication). Diethylenetriaminepentaacetic acid calcium trisodium salt hydrate is a nontoxic inhibitor of CMV replication .
|
-
- HY-W782075
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-NO2-Bn-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NO2-Bn-DOTA can be used for conjugation of peptides and radionuclides.
|
-
- HY-48876
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-NH2-Bn-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NH2-Bn-DOTA can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717742
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-NO2-Bn-Cyclenis a bifunctional chelator (Bifunctional Chelator; BFC), which is a derivative of the macrocyclic ligand dodecane backbone Cyclen. p-NO2-Bn-Cyclen can be used for conjugation of peptides and radionuclides.
|
-
- HY-158069
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-NH?-Bn-DTPA-penta (t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-NH?-Bn-DTPA-penta (t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W460274
-
|
|
Biochemical Assay Reagents
|
Others
|
|
4-Aminobutyl-DOTA-tris(t-butyl ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. 4-Aminobutyl-DOTA-tris(t-butyl ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-158066
-
-
- HY-W250929
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Maleimido-mono-amide-DOTA-tris(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Maleimido-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-148646A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-NH2-CHX-A"-DTPA (hydrochloride hydrate)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-NH2-CHX-A"-DTPA (hydrochloride hydrate) can be used for conjugation of peptides and radionuclides.
|
-
- HY-126164
-
|
|
Biochemical Assay Reagents
|
Others
|
|
LK 614 is a membrane permeable iron chelator that can be used to study the protective effects against L-Histidine (HY-N0832)-induced cell damage .
|
-
- HY-124452
-
|
Desferrioxamine E; Nocardamin
|
Bacterial
|
Others
|
|
Nocardamine (Deferrioxamine E)is an iron carrier/Iron chelator with antimicrobial activity .
|
-
- HY-W749603
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W749614
-
-
- HY-W782081
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-SCN-Bn-oxo-DO3Ais a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-SCN-Bn-oxo-DO3A can be used for conjugation of peptides and radionuclides.
|
-
- HY-160607
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Others
|
|
MMA-NODAGA is a chelator for site-specific labeling of targeting proteins containing unpaired cysteine. MMA-NODAGA can be used to conjugate with exosome and 64Cu in image with positron emission tomography (PET) <[2].
|
-
- HY-W717760
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-NH2-Bn-DOTA-tetra(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NH2-Bn-DOTA-tetra(t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W782080
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-NH2-Bn-oxo-DO3Ais a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NH2-Bn-oxo-DO3A can be used for conjugation of peptides and radionuclides.
|
-
- HY-108194
-
|
|
Biochemical Assay Reagents
|
Others
|
|
CGP 46700 (Compound 49) is an orally active iron chelator, that exhibits high affinity for iron, removes iron from ferritin and human serum transferrin. CGP 46700 promotes iron excretion in a mouse iron overload model .
|
-
- HY-W102590
-
|
|
Biochemical Assay Reagents
|
Others
|
|
DOTMP is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
-
- HY-W004649
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Tris-BOC-cyclen is a bifunctional chelator. Bifunctional chelating agentscan be used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
-
- HY-W402032
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis-Cbz-cyclen is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
-
- HY-45290
-
|
|
Biochemical Assay Reagents
|
Others
|
|
trans-1,2-Cyclohexanediaminetetraacetic acid is a commonly used aminopolycarboxylic acid and a strong chelator of heavy metal ions .
|
-
- HY-100133A
-
|
|
Integrin
|
Cancer
|
|
DOTA-ADIBO TFA is a DOTA-derived bifunctional chelator (BFC) that allows drug conjugation via an uncatalyzed, copper-free cycloaddition reaction. DOTA-ADIBO TFA enables the construction of fusion chelator systems that can be further used to synthesize radiotracers after Cu[64] modification. Positron emission tomography imaging of tumors expressing integrin αvβ6 .
|
-
- HY-126905
-
|
NSC328784
|
Reactive Oxygen Species
|
Cancer
|
|
ZMC3 (NSC328784) is a zinc chelator. ZMC3 shows Zinc metallochaperone properties. ZMC3 shows enhanced sensitivity in p53-R175H mutant cells. ZMC3 increases the cell ROS level .
|
-
- HY-132927B
-
|
|
Reactive Oxygen Species
|
Inflammation/Immunology
|
|
Salpyran dihydrochloride is a Cu(II) selective chelator with therapeutic potential. Salpyran dihydrochloride prevents the formation of reactive oxygen species from the binary Cu(II)/H2O2 system .
|
-
- HY-D1636
-
|
|
Fluorescent Dye
|
Others
|
|
5-Nitro BAPTA is a calcium chelator, combinded with 2-Me-substituted TM ( as a fluorescent moiety), can be used to form a red fluorescent probe (CaTM-2 AM), for imaging of cytoplasmic Ca 2+ in cultured living cells. 5-Nitro BAPTA is a building block used in the synthesis of Ca 2+ specific chelators, Ca 2+ buffers, and fluorescent Ca 2+ indicators .
|
-
- HY-D0973
-
EGTA-AM
5 Publications Verification
EGTA Acetoxymethyl ester
|
Biochemical Assay Reagents
|
Neurological Disease
|
|
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca 2+ chelator with slow chelating dynamics.
|
-
- HY-E70382
-
|
|
Phosphatase
Biochemical Assay Reagents
|
Others
|
|
Shrimp Alkaline Phosphatase (SAP), a nucleotide phosphatase, can catalyze the removal of 5′ phosphates from nucleic acid templates. Shrimp Alkaline Phosphatase is readily inactivated in the absence of chelators and is widely used phosphatases in molecular cloning .
|
-
- HY-D0861A
-
|
|
Biochemical Assay Reagents
|
Inflammation/Immunology
|
|
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages .
|
-
- HY-133513
-
|
(±)-H3L28
|
Drug Derivative
|
Cancer
|
|
(±)-H3RESCA-TFP ((±)-H3L28) is a tetrafluorophenyl ester derivative of restrained complexing agent (RESCA). (±)-H3RESCA-TFP can be used to conjugate the chelator with a biomolecule via amine coupling (e.g., N terminus and/or the ε-amino groups of lysine) .
|
-
- HY-D1746
-
|
EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
|
Biochemical Assay Reagents
|
Others
|
|
EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
|
-
- HY-124712
-
|
|
Bacterial
|
Infection
|
|
Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm .
|
-
- HY-N8707
-
|
|
Parasite
HDAC
NF-κB
|
Infection
Inflammation/Immunology
Cancer
|
|
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .
|
-
- HY-W686216
-
|
|
Ferroptosis
|
Neurological Disease
|
|
VK-28, a brain-permeable iron chelator, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 μM. VK-28 exhibits significant neuroprotective effects on ICV-6-OHDA. VK-28 can be used for the research of Parkinson’s disease and other neurodegenerative diseases .
|
-
- HY-108260
-
|
GT-56-252
|
Ferroptosis
|
Cardiovascular Disease
|
|
Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major .
|
-
- HY-170433
-
|
|
Apoptosis
Ferroptosis
|
Cancer
|
|
DefNEtTrp is a Fe dual chelator ligand, consisting of the Def and Trp moieties. DefNEtTrp exhibits potent and broad-spectrum antiproliferative and cell death behavior in cancer cell lines. DefNEtTrp induces both apoptosis and ferroptosis and has cytotoxicity with an IC50 value of 0.77 μM .
|
-
- HY-D0261
-
-
- HY-N0928
-
|
|
Apoptosis
|
Inflammation/Immunology
Cancer
|
|
Mimosine, a tyrosine analog , can act as an antioxidant by its potent iron-binding activity . Mimosine is a known chelator of Fe(III) . Mimosine induces apoptosis through metal ion chelation, mitochondrial activation and ROS production in human leukemic cells . Anti-cancer, antiinflammation.
|
-
- HY-W004544
-
|
1,10-Phenanthroline
|
MMP
|
Others
|
|
o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe 2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor .
|
-
- HY-100545
-
|
|
Potassium Channel
|
Cardiovascular Disease
|
|
BAPTA-AM is a well-known membrane permeable Ca 2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively .
|
-
- HY-D0836
-
|
Ethylenediaminetetraacetic acid dipotassium dihydrate
|
DNA/RNA Synthesis
|
Others
|
|
EDTA dipotassium dihydrate is a metal ion chelator that forms stable and water-soluble chelates with a variety of metal ions. EDTA dipotassium is commonly used as a blood anticoagulant, which can effectively prevent blood coagulation and maintain the morphology and function of cells in blood samples. In the industrial field, EDTA dipotassium can be used to remove the adverse effects of metal ions and prevent oxidation and deterioration caused by metal ions .
|
-
- HY-116767
-
BLT-1
3 Publications Verification
Block lipid transport-1
|
HCV
|
Metabolic Disease
Inflammation/Immunology
|
|
BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor .
|
-
- HY-135433
-
-
- HY-132927
-
-
- HY-13950
-
-
- HY-W017165
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Sodium malonate hydrate is a complexing agent for the determination of beryllium and copper. Sodium malonate hydrate is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-18973
-
-
- HY-B2153
-
|
|
Cuproptosis
|
Metabolic Disease
|
|
Tetraethylenepentamine pentahydrochloride is an effective chelator in increasing the urinary excretion of copper .
|
-
- HY-D0855
-
-
- HY-120391
-
|
|
Biochemical Assay Reagents
|
Others
|
|
LiLo is a new bifunctional chelator that has the activity of forming kinetically stable chelates with metal ions (such as indium). After using LiLo to bind indium-111 to monoclonal antibodies, the in vitro stability and in vivo biodistribution of the conjugates are superior to those using other chelators.
|
-
- HY-12691
-
-
- HY-100329
-
|
|
Ferroptosis
|
Others
|
|
CGP 65015 is an oral iron chelator, which can mobilize iron deposits.
|
-
- HY-131036
-
|
|
Monoamine Oxidase
|
Neurological Disease
|
|
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W614269
-
-
- HY-156776
-
|
|
Ferroptosis
|
Others
|
|
HAPSBC is an S-benzyl iron chelator that mobilizes intracellular 59Fe distribution .
|
-
- HY-160131
-
-
- HY-N14930
-
-
- HY-18670
-
-
- HY-16912
-
|
SP-420
|
Ferroptosis
|
Others
|
|
SP-420 is a tridentate iron chelator belonging to the class of iron chelators, with oral activity. It is a derivative of desferrithiocin but has higher iron clearance efficiency and minimized renal toxicity compared to desferrithiocin, with an ICE (Iron Clearance Efficiency) value of 26.7. SP-420 can be used in research related to β-thalassemia .
|
-
- HY-P10137
-
|
JR11
|
Somatostatin Receptor
|
Cancer
|
|
Satoreotide (JR11) is a SSTR2 antagonist. Satoreotide is usually conjugated with radiolabeled chelators used in neuroendocrine tumor imaing .
|
-
- HY-132851
-
|
|
ADC Cytotoxin
|
Cancer
|
|
Corixetan is a highly efficient thorium chelator. Corixetan can efficiently complex Th-227 with sufficient in vivo stability .
|
-
- HY-157977
-
-
- HY-121872
-
|
|
Others
|
Neurological Disease
|
|
DP-b99 is a chelator of zinc and calcium ions that acts selectively within cell membranes and has neuroprotective properties in animal models of stroke.
|
-
- HY-147962
-
|
|
Cholinesterase (ChE)
HDAC
|
Neurological Disease
|
|
COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research .
|
-
- HY-164574
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
BCN-DOTA is a cyclooctyne-linked DOTA chelator that can be radiolabeled with zirconium-89 as a radionuclide-labeled drug conjugate (RDC) to target specific biomolecules, cells, or tissues.
|
-
- HY-D1758
-
|
|
Fluorescent Dye
|
Others
|
|
Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
|
-
- HY-159888
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
SON38 is a copper chelator capable of chelating divalent copper. SON38 can inhibit the activity of cholinesterases and has potential applications in Alzheimer's disease research .
|
-
- HY-D1759
-
|
|
Fluorescent Dye
|
Others
|
|
Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
|
-
- HY-W094510
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Sodium pyrophosphate decahydrate can be as a buffering agent, a chelator and a hydrated salt nucleating agent. Sodium pyrophosphate decahydrate can also be used to a raw material for synthetic laundry scent additives .
|
-
- HY-17359S
-
-
- HY-164577
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
BCN-DOTA-GA is a cyclooctyne-linked DOTA chelator that can be labeled with radioactive zirconium-89 and used as a radionuclide-labeled drug conjugate (RDC) to target specific biomolecules, cells or tissues.
|
-
- HY-160078
-
|
|
Others
|
Metabolic Disease
|
|
Deferiprone O-β-D-glucuronide is a novel orally active iron chelator. Deferiprone O-β-D-glucuronide shows the capability of reducing the iron burden in patients with β-thalassemia .
|
-
- HY-17359R
-
|
ICL 670 (Standard)
|
Bacterial
Ferroptosis
|
Cancer
|
|
Deferasirox (Standard) is the analytical standard of Deferasirox. This product is intended for research and analytical applications. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .
|
-
- HY-145888
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Antioxidant agent-2 (comp 3c), an BBB-penetrated antioxidant agent and a selective metal ions chelator, presents good neuroprotective effect and hepatoprotective effect for the study of Alzheimer’s disease .
|
-
- HY-122939
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
MAIPGG is a bifunctional chelator and an intermediate in the synthesis of radionuclide drug conjugates (RDCs). MAIPGG can be for the radiolabeling of a variety of monoclonal antibodies with 99mTc or 186Re, which then can be used for radioimmunodetection and radioimmunotherapy of cancer .
|
-
- HY-104058
-
|
Oregon Green 488 BAPTA 1AM
|
Fluorescent Dye
|
Others
|
|
Oregon-BAPTA Green 1AM (Oregon Green 488 BAPTA 1AM) is a fluorescent Ca 2+ indicator that consists of a green fluorescent probe OG 488 and a cell-permeable Ca 2+ chelator BAPTA AM.
|
-
- HY-131673
-
|
|
Biochemical Assay Reagents
|
Others
|
|
p-SCN-Bn-TCMC tetrahydrochloride is a bifunctional chelator that exhibits high reactivity due to its powerful TCMC component, making it effective for binding radio-isotopic heavy metal ions, which are essential in radio-diagnostic imaging applications.
|
-
- HY-110075
-
|
|
Others
|
Cardiovascular Disease
|
|
Dexrazoxane monohydrochloride is the hydrochloride of Dexrazoxane (HY-B0581). Dexrazoxane can prevent or reduce cardiac damage and is an iron chelator and apoptosis inducer. Dexrazoxane has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities and inhibits ferroptosis .
|
-
- HY-P10273
-
-
- HY-164569
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
NH2 DOTA-GA is a DOTA-based metal chelator that can be used to prepare radionuclide drug conjugates (RDCs) whose carboxylic acid groups can complex metal ions. For example, NH2 DOTA-GA complexes Gd(III) ions.
|
-
- HY-P10273A
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Biochemical Assay Reagents
|
Cancer
|
|
DOTA-Octreotide TFA is composed of chelator DOTA and Octreotide (HY-P0036). DOTA-Octreotide TFA is used for research of cancer through combination with radioactive elements. DOTA-Octreotide TFA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .
|
-
- HY-W012898
-
|
Biacetyl dioxime
|
Biochemical Assay Reagents
|
Others
|
|
Dimethylglyoxime (Biacetyl dioxime) belongs to the class of oximes and consists of two acetyl groups attached to a nitrogen atom, which in turn is attached to another nitrogen atom through a diimine bond. Dimethylglyoxime is a specific chelator of Ni that inhibits or slows the aggregation of Aβ peptides in vitro .
|
-
- HY-164588
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
NH2-PEG4-NODA-GA is a NODA-type metal chelator that can bind to radionuclides to prepare radionuclide drug conjugates (RDCs). RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy.
|
-
- HY-169298
-
|
|
Ferroptosis
|
Cancer
|
|
Ferroptosis-IN-15 (compound 12) is a potent inhibitor of ferroptosis, with the EC50s of 0.76 and 0.67 μM in A375 cells and 786-O cells, respectively.Ferroptosis-IN-15 is a potential iron chelator and radical trapping antioxidant .
|
-
- HY-126907
-
-
- HY-159943
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
ROS151 is an AChE inhibitor, with IC50s of 14 nM (hAChE), 1.68 μM (eqBChE), 8.17 μM (hFAAH) respectively. ROS151 is also a chelator of Fe 3+ and Cu 2+. ROS151 can be used for research of Alzheimer's disease .
|
-
- HY-W035520
-
|
|
Biochemical Assay Reagents
|
Others
|
|
HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy .
|
-
- HY-103528
-
|
Salicylidene salicylhydrazide
|
GABA Receptor
|
Neurological Disease
Inflammation/Immunology
|
|
SCS (Salicylidene salicylhydrazide) is a potent, allosteric and selective inhibitor of β1-containing GABAA receptors with an IC50 of 32 nM against α2β1γ1θ by VIPR measurement. SCS is also a chelator of metal ions .
|
-
- HY-W241345
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies.
|
-
- HY-D1639
-
|
|
Fluorescent Dye
|
Others
|
|
5,5'-Dibromo BAPTA tetrapotassium is a calcium chelator, can be formulated into a buffer with a defined calcium ion concentration. 5,5'-Dibromo BAPTA tetrapotassium can control the concentration of calcium ions inside and outside the cell and can be used in studies of calcium physiological activity .
|
-
- HY-Y1841
-
|
1,10-Phenanthroline monohydrate
|
MMP
|
Others
|
|
o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe 2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor .
|
-
- HY-113354
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .
|
-
- HY-142072
-
|
|
Antibiotic
DNA/RNA Synthesis
Bacterial
|
Infection
|
|
Albomycin is an inhibitor of aminoacyl-tRNA synthetases with Trojan-horse effect. Albomycin is delivered by iron-chelator portion into bacterial through ferrichrome-specific transporter system. Albomycin combats against a wide range of Gram-positive and Gram-negative bacteria. Albomycin also serves as an efficient iron-scavenger of producer .
|
-
- HY-100202
-
|
TPEDA
|
Reactive Oxygen Species
Apoptosis
Autophagy
|
Cancer
|
|
TPEN (TPEDA) is a specific cell-permeable heavy metal chelator. TPEN has a higher affinity for Zn 2+, but a lower affinity for Mg 2+ and Ca 2+. TPEN induces DNA damage and increases intracellular ROS production. TPEN also inhibits cell proliferation and induces apoptosis .
|
-
- HY-W005561
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Dab(Boc)-OMe hydrochloride is an N-terminally protected diaminobutyric acid containing two protecting groups: methoxy (OMe) and tert-butyloxycarbonyl (Boc). H-Dab(Boc)-OMe hydrochloride can be used to synthesize the bifunctional chelator H3Dpaa that can rapidly complex 68Ga under physiological conditions .
|
-
- HY-D1643
-
|
|
Biochemical Assay Reagents
|
Others
|
|
5,5'-Dinitro BAPTA AM is a membrane-permeant, high-affinity calcium chelator, it can be used for investigation of the role of cytosolic Ca 2+. 5,5'-Dinitro BAPTA AM can be loaded by incubation into live cells, and is cleaved by cytosolic esterases to liberate the active tetra-carboxylate ligand .
|
-
- HY-W011060
-
|
4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane
|
Biochemical Assay Reagents
|
Others
|
|
Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+) .
|
-
- HY-W011118
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
DTPA anhydride is a bifunctional chelator whose anhydride can react with amino groups in proteins (such as lysine residues) to form stable amide bonds. DTPA anhydride can also bind to radionuclides to synthesize radionuclide-labeled drug conjugates (RDCs). RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy.
|
-
- HY-164364B
-
|
|
FAP
|
Cancer
|
|
DOTAGA.(SA.FAPi)2 analogue TFA is a DOTAGA.(SA.FAPi)2 TFA (HY-164364A) analogue, in which the ligand and the chelator are identical to those of DOTAGA.(SA.FAPi)2 TFA. DOTAGA.(SA.FAPi)2 TFA is a potent dimeric fibroblast-activation protein inhibitor (FAPi) .
|
-
- HY-120743
-
|
|
Biochemical Assay Reagents
|
Metabolic Disease
|
|
Triplin is a copper chelator, Triplin perturbs copper ion transport involved in the interaction of RAN1 and ATX1. Triplin suppresses the toxic effects of excess copper ions on plant root growth. Triplin increases the RNA expression of ERF1. Triplin acts through the ethylene signal transduction pathway. Triplin also is a bacterial pore-former .
|
-
- HY-P99239
-
|
HUJ-591
|
PSMA
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
Rosopatamab (HuJ591) is a humanized antiPSMA IgG1 monoclonal antibody that can be used in cancer research, especially prostate cancer. Rosopatamab can be linked to the low-energy beta-emitting radioisotope lutetium-177 ( 177Lu) through the bifunctional chelator DOTA-NHS ester to obtain a radioimmunoconjugate that targets malignant prostate cells with high efficiency .
|
-
- HY-B0300
-
|
D-(-)-Penicillamine
|
Cuproptosis
Drug Metabolite
|
Inflammation/Immunology
Cancer
|
|
Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .
|
-
- HY-113354S
-
|
|
Endogenous Metabolite
|
Neurological Disease
|
|
Anserine-d4 is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].
|
-
- HY-W111692
-
|
|
Biochemical Assay Reagents
|
|
|
Sodium polyphosphate, crystal, +200 mesh, 96% is a water-soluble inorganic stabilizer with surfactant and metal ion chelator activity. Sodium polyphosphate, crystal, +200 mesh, 96% can be widely used in food, cosmetics and industrial products to improve product texture and stability. Sodium polyphosphate, crystal, +200 mesh, 96% also helps prevent metal ion-induced degradation and extend the product's life.
|
-
- HY-P10846
-
|
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
HYNIC-CTP is a conjugate of HYNIC and CTP (cardiac-targeting peptide). HYNIC-CTP can bind with the radionuclide 99mTc through HYNIC acting as a chelator, forming 99mTc-HYNIC-CTP. 99mTc-HYNIC-CTP is specifically taken up by the heart and used for cardiac imaging, thereby facilitating research into heart diseases .
|
-
- HY-P6351
-
|
|
Integrin
|
Cancer
|
|
c(avb6)-DOTA TFA is a conjugate of the αvβ6 integrin selective peptide ring modified with DOTA chelator. The Lu(III) complex of c(avb6)-DOTA TFA has a comparable affinity for αvβ6 integrin (IC50=0.8 nM) and can be used as a tumor diagnostic .
|
-
- HY-D0716
-
|
Fluo-3-pentaacetoxymethyl ester
|
Fluorescent Dye
|
Others
|
|
Fluo-3 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-W012788
-
Maltol
2 Publications Verification
|
Endogenous Metabolite
Apoptosis
|
Infection
Neurological Disease
|
|
Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .
|
-
- HY-W105699
-
|
Ethylenediaminetetraacetic acid tetrasodium tetrahydrate
|
Biochemical Assay Reagents
|
Others
|
|
EDTA tetrasodium tetrahydrate is a metal chelator (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. EDTA tetrasodium tetrahydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. EDTA tetrasodium tetrahydrate can also decrease the formation of disulfide bonds .
|
-
- HY-101902
-
|
Quin-2 acetoxymethyl ester
|
Fluorescent Dye
|
Others
|
|
Quin-2AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-113354S1
-
|
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Anserine-d4 hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .
|
-
- HY-D1498
-
|
|
Fluorescent Dye
|
Others
|
|
Mag-Fluo-4 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-W004544S
-
|
1,10-Phenanthroline-d8
|
Isotope-Labeled Compounds
MMP
|
Others
|
|
o-Phenanthroline-d8 is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor[1][2].
|
-
- HY-117410
-
|
PSMA-617
|
Drug-Linker Conjugates for ADC
|
Cancer
|
|
Vipivotide tetraxetan (PSMA-617) is a high potent prostate-specific membrane antigen (PSMA) inhibitor, with a Ki of 0.37 nM. Vipivotide tetraxetan (PSMA-617) is designed consisting of three components: the pharmacophore Glutamate-urea-Lysine, the chelator DOTA able to complex both 68Ga or 177Lu, and a linker connecting these two entities. Glutamate-urea-Lysine is the selective pharmacophore to bind to prostate specific membrane antigen.
|
-
- HY-149090
-
|
|
Cholinesterase (ChE)
Monoamine Oxidase
|
Neurological Disease
|
|
AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent AChE/BuChE inhibitor and showed good blood brain barrier (BBB) permeability in vitro with an IC50 value of 5.3 μM, 12.4 μM, 1.9±0.08 μM, for AChE, BuChE, huMAO-B, respectively. AChE/BuChE/MAO-B-IN-2 (compound 4b) can inhibit excess AChE/BuChE in Alzheimer's disease (AD) brain. AChE/BuChE/MAO-B-IN-2 (compound 4b) can be used in anti-Alzheimer's research .
|
-
- HY-P10743
-
|
|
Radionuclide-Drug Conjugates (RDCs)
PSMA
|
Cancer
|
|
BQ7876 is a probe targeting prostate-specific membrane antigen (PSMA) that contains a DOTA chelator. BQ7876, after being radiolabeled with radionuclide (177Lu), functions in both radionuclide imaging and tumor cell destruction by specifically binding to PSMA. BQ7876 shows potential for research in the field of metastatic castration-resistant prostate cancer (mCRPC) . BQ7876 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
|
-
- HY-Y0682S
-
|
Ethylenediaminetetraacetic acid-d12
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
EDTA-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
|
-
- HY-P10913
-
|
|
Bacterial
|
Infection
|
|
HYNIC-UBI29-41 is composed of a bifunctional chelator HYNIC and an antimicrobial peptide UBI 29-41. HYNIC-UBI29-41 retains the antibacterial properties of UBI 29-41, and exhibits good affinity to Gram-positive and Gram-negative bacteria. HYNIC-UBI29-41 can be used as an imaging agent for bacterial infection detection in mouse models, when labeled with the radioactive element technetium (99mTc) .
|
-
- HY-B0300R
-
|
|
Cuproptosis
Drug Metabolite
|
Inflammation/Immunology
Cancer
|
|
Penicillamine (Standard) is the analytical standard of Penicillamine. This product is intended for research and analytical applications. Penicillamine (D-(-)-Penicillamine) is a penicillin metabolic degradation product, can be used as a heavy metal chelator. Penicillamine reduces free copper and reduces oxidative stress. Penicillamine has effect of seizures through nitric oxide/NMDA pathways. Penicillamine is a potential immune modulator. Penicillamine can be used for the research of Wilson disease, rheumatoid arthritis, and cystinuria .
|
-
- HY-Y0682S1
-
|
EDTA-d16
|
Isotope-Labeled Compounds
|
Neurological Disease
|
|
Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
|
-
- HY-169268
-
|
|
Amyloid-β
|
Neurological Disease
|
|
Aβ-IN-10 (Compound Alz -5) is a bifunctional copper chelator and an inhibitor for beta-amyloid (Aβ), that interacts with Aβ aggregates and reduces the neurotoxicity. Aβ-IN-10 exhibits antioxidant efficacy, reveals moderate cytotoxicity with the presence of CuCl2 in SH-SY5Y and HepG2 with IC50 of 65.5, 31.2 μM. Aβ-IN-10 reduces the increase of cell stiffness caused by Aβ .
|
-
- HY-W011060R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2. This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn2+, Co2+, Ni2+, Cu2+) .
|
-
- HY-W339484
-
|
|
Biochemical Assay Reagents
|
Others
|
|
1-Ethyl-2-methyl-3-hydroxypyrid-4-one is an α-ketohydroxypyridinium iron chelator with high specificity for iron and no specific activity against other metal ions such as copper, zinc, calcium and magnesium. In rabbits with iron overload, 1-Ethyl-2-methyl-3-hydroxypyrid-4-one increased iron excretion after oral or parenteral administration.
|
-
- HY-120475
-
|
ATH434
|
α-synuclein
|
Neurological Disease
|
|
PBT434 is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 has the potential for the research of Parkinson’s disease (PD) .
|
-
- HY-W012788R
-
|
|
Endogenous Metabolite
Apoptosis
|
Infection
Neurological Disease
|
|
Maltol (Standard) is the analytical standard of Maltol. This product is intended for research and analytical applications. Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .
|
-
- HY-W012788S
-
|
|
Isotope-Labeled Compounds
Endogenous Metabolite
Apoptosis
|
Infection
Neurological Disease
|
|
Maltol-d3 is a deuterium labeled Maltol (HY-W012788). Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .
|
-
- HY-144659
-
|
|
Beta-lactamase
Apoptosis
Bacterial
|
Infection
|
|
Metallo-β-lactamase-IN-5 (compound 5c) is a potent metallo-β-lactamases (MBL) inhibitor. Metallo-β-lactamase-IN-5 shows inhibitory activity against MBLs NDM-1 and VIM-1. Metallo-β-lactamase-IN-5 inhibits HUVECs with an IC50 of 45 μg/mL. Metallo-β-lactamase-IN-5 plus Imipenem exhibits synergistic antimicrobial activity .
|
-
- HY-12406
-
|
|
Oxidative Phosphorylation
Mitochondrial Metabolism
Autophagy
|
Cancer
|
|
VLX600 is an iron-chelating inhibitor of oxidative phosphorylation (OXPHOS). VLX600 causes mitochondrial dysfunction and induces a strong shift to glycolysis. VLX600 displays selective cytotoxic activity against malignant cell and induces autophagy. Anticancer activity .
|
-
- HY-40309
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Dibenzo-18-crown-6 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W127836
-
|
(S)-1-(4-Aminoxyacetamidobenzyl)ethylenediaminetetraacetic acid
|
Biochemical Assay Reagents
|
Others
|
|
(S)-1-(4-Aminoxyacetamidobenzyl)ethylenediaminetetraacetic Acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W052750
-
|
|
Biochemical Assay Reagents
|
|
|
5-Carboxy-2-thiouracil is a compound with antitumor activity that can form complexes with metal ions, thereby exhibiting significant biological effects.
|
-
- HY-131926R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
EDTA (iron sodium) (Standard) is the analytical standard of EDTA (iron sodium). This product is intended for research and analytical applications. EDTA iron sodium (NaFeEDTA; Sodium iron EDTA) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-Y0682R
-
|
|
Biochemical Assay Reagents
Bacterial
SOD
|
Cardiovascular Disease
Neurological Disease
Cancer
|
|
Ethylenediaminetetraacetic acid (Standard) is the analytical standard of Ethylenediaminetetraacetic acid. This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research [4] .
|
-
- HY-W128312
-
-
- HY-W109973
-
|
L-(+)-Tartaric acid diammonium
|
Endogenous Metabolite
|
Cardiovascular Disease
|
|
L-Tartaric acid diammonium (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. L-Tartaric acid diammonium has vasodilatory and antihypertensive effects. L-Tartaric acid diammonium can be used as flavorings and antioxidants in a range of foods and beverages. L-Tartaric acid diammonium can be used in laser frequency doubling and optical limiting applications .
|
-
- HY-W004650
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TETA hydrochloride hydrate is an effective selective chelating agent for copper (II). TETA hydrochloride hydrate can be used for drug coupling .
|
-
- HY-Y0262B
-
|
Ethanedioic acid (sodium),ACS, 99.5%
|
Biochemical Assay Reagents
|
Others
|
|
Sodium oxalate,ACS,99.5% (Ethanedioic acid (sodium),ACS, 99.5%) is a biochemical assay reagent.
|
-
- HY-Y0682
-
|
EDTA
|
Biochemical Assay Reagents
Bacterial
SOD
|
Cardiovascular Disease
Neurological Disease
Cancer
|
|
Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .
|
-
- HY-W555991
-
|
|
Biochemical Assay Reagents
|
|
|
2',3'-O-Isopropylidene-6-mercaptopurine riboside is a compound with excellent metal complexing activity. 2',3'-O-Isopropylidene-6-mercaptopurine riboside can be used to study the mechanism of metal complexing.
|
-
- HY-W087947
-
|
Ethylenediaminetetraacetic acid dihydrate tripotassium
|
Biochemical Assay Reagents
|
Others
|
|
EDTA·2H2O (tripotassium) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-21323R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Isophthalic acid (Standard) is the analytical standard of Isophthalic acid. This product is intended for research and analytical applications. Isophthalic acid is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-W127831
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Aminomethyl-15-crown-5 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W105875
-
-
- HY-W103245
-
|
B18C6
|
Biochemical Assay Reagents
|
Others
|
|
Benzo-18-crown-6-ether (B18C6) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K +; when Mg 2+ ions are present, 18-Crown-6-ether and K + ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load .
|
-
- HY-W106012
-
-
- HY-W691498
-
-
- HY-W108801
-
|
|
Biochemical Assay Reagents
|
|
|
α-D-Glucoheptonic acid sodium is a compound that modulates the immune system, has chelating activity, and can be used in the preparation of cleaning agents.
|
-
- HY-163966R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Decarboxyl ofloxacin (Standard) is the analytical standard of Decarboxyl ofloxacin. This product is intended for research and analytical applications. (±)-myo-Inositol-1-phosphate is a biochemical assay reagent.
|
-
- HY-131926
-
|
Ethylenediaminetetraacetic acid iron sodium
|
Biochemical Assay Reagents
|
Others
|
|
EDTA iron sodium (NaFeEDTA; Sodium iron EDTA) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-167181
-
-
- HY-111413
-
|
|
Integrin
|
Cancer
|
|
c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM .
|
-
- HY-W013851
-
|
|
Biochemical Assay Reagents
|
Others
|
|
EDTA-OH is a chelating agent, which forms thermodynamically stable chelates with metal ions like calcium, magnesium, iron, zinc and copper . EDTA-OH exhibits ability of phytoremediation in heavy-metal-contaminated soils . EDTA-OH is able to cross brain-blood barrier .
|
-
- HY-D0850
-
|
Sodium tartrate dibasic dihydrate; Sodium tartrate dihydrate
|
Phosphatase
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications .
|
-
- HY-W539893
-
|
NODAG
|
Biochemical Assay Reagents
|
Cancer
|
|
NODAGA-tris(t-Bu ester) (NODAG) is a NODAGA derivative. NODAGA-tris(t-Bu ester) can be used to label peptides, antibodies, etc., and subsequently radiolabeled for PET imaging .
|
-
- HY-W015236
-
|
Triglycine
|
Biochemical Assay Reagents
|
Others
|
|
H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.
|
-
- HY-W031536R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
2-Imidazolidone, 96% (Standard) is the analytical standard of 2-Imidazolidone, 96%. This product is intended for research and analytical applications. 2-Imidazolidone, 96% is a chelating agent that forms complexes with metal ions, enabling its use in catalytic processes.
|
-
- HY-107921
-
|
EDTA calcium disodium salt,98%; Adsorbonac,98%
|
Biochemical Assay Reagents
|
Others
|
|
EDTA Calcium disodium, 98% (EDTA calcium disodium salt, 98%; Adsorbonac, 98%) is a chelating agent for calcium and other metal ions, preventing them from participating in chemical reactions. It can effectively remove metal ions from solutions, preventing them from interfering with experimental processes.
|
-
- HY-B0812
-
|
SSA dihydrate
|
Biochemical Assay Reagents
|
Cancer
|
|
5-Sulfosalicylic acid dihydrate is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid dihydrate is effective against the breast cancer cell line, MCF-7, with less toxicity . 5-Sulfosalicylic acid dihydrate has antioxidant activities .
|
-
- HY-W008951
-
-
- HY-W127744R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Chlorophyll a (Standard) is the analytical standard of Chlorophyll a. This product is intended for research and analytical applications. Chlorophyll a is a plant extract.
|
-
- HY-W127802
-
|
(Rac)-(Bromoacetamidophenylmethyl)ethylenediaminetetraacetic acid
|
Biochemical Assay Reagents
|
Others
|
|
(Rac)-EDTA-bromoacetamidophenylmethyl is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-Y0682AR
-
|
|
Biochemical Assay Reagents
Bacterial
SOD
|
Cardiovascular Disease
Neurological Disease
Cancer
|
|
Ethylenediaminetetraacetic acid (disodium dihydrate) (Standard) is the analytical standard of Ethylenediaminetetraacetic acid (disodium dihydrate). This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research [4] .
|
-
- HY-W111522
-
|
di-Sodium hydrogen phosphite, 98%
|
Biochemical Assay Reagents
|
Others
|
|
Sodium phosphite dibasic pentahydrate, 98% is a metal chelating agent used to remove copper ions from water supplies.
|
-
- HY-W140537
-
|
|
Biochemical Assay Reagents
|
Others
|
|
EDTA diammonium salt hydrate, 97% is a derivative of ethylenediaminetetraacetic acid (EDTA), commonly used as a chelating agent in various applications due to its ability to bind with various metal ions and form stable complexes.
|
-
- HY-W008563
-
-
- HY-W749867
-
|
Calcium disodium EDTA dihydrate
|
Bacterial
|
Infection
Others
|
|
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning .
|
-
- HY-157917
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .
|
-
- HY-W007451
-
|
|
Biochemical Assay Reagents
|
Others
|
|
15-Crown-5 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W127779
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Deferasirox iron complex is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W130354
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Cucurbituril is a container molecule resembling a hollow pumpkin, with two identical inlets at each end and a hydrophobic cavity in the middle. Cucurbiturils have unique chemical properties that allow them to selectively encapsulate guest molecules such as drugs or catalysts within their cavities, shielding them from the surrounding environment. Cucurbituril has important potential applications in various fields such as drug delivery, catalysis and materials science.
|
-
- HY-W025784R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Kalibor (Standard) is the analytical standard of Kalibor. This product is intended for research and analytical applications. Kalibor (Sodium tetraphenylborate; Tetraphenylboron sodium) is a precipitating agent, performing a precipitating function in the gravimetric determination of various monovalent cations such as basic organic nitrogen compounds and metal ions .
|
-
- HY-W004563
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Neocuproine is an organic compound commonly used as a complexing reagent and copper ion detector. It can form stable complexes with copper ions, and can play a catalytic role in certain chemical reactions and analytical methods. In addition, this compound is also widely used in some biomedical fields, such as in the study of copper metabolism disorders and neurodegenerative diseases
|
-
- HY-W127785R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
N-ethyl-N-oxido-dodecan-1-amine (Standard) is the analytical standard of N-ethyl-N-oxido-dodecan-1-amine. This product is intended for research and analytical applications. N-ethyl-N-oxido-dodecan-1-amine is an amine oxide surfactant commonly used as a detergent, emulsifier and wetting agent in various industrial processes, especially in personal care products and household cleaning in the production of agents. N,N-Dimethyldodecylamine N-oxide has unique chemical properties that make it an effective ingredient in many product formulations to help reduce surface tension and enhance cleaning power.
|
-
- HY-W127785
-
|
N,N-Dimethyldodecylamine N-oxide; Dodecyldimethylamine oxide
|
Biochemical Assay Reagents
|
Others
|
|
N-ethyl-N-oxido-dodecan-1-amine is an amine oxide surfactant commonly used as a detergent, emulsifier and wetting agent in various industrial processes, especially in personal care products and household cleaning in the production of agents. N,N-Dimethyldodecylamine N-oxide has unique chemical properties that make it an effective ingredient in many product formulations to help reduce surface tension and enhance cleaning power.
|
-
- HY-D0180
-
|
18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane
|
Biochemical Assay Reagents
|
Others
|
|
18-Crown-6-ether (18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K +; when Mg 2+ ions are present, 18-Crown-6-ether and K + ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load .
|
-
- HY-157926
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Nitroso-PSAP is a sensitive and specific chromogenic reagent for iron (Fe 2+), which is used for the colorimetric determination of iron in blood after mineralization with periodic acid. TNitroso-PSAP chelates with iron (Fe 2+) to produce a green complex (λmax=756 nm, Epsilon = 4.5 x 10 < sup > 4 < / sup > dm < sup > 3 < / sup > mol < sup > 1 < / sup > cm < sup > 1 < / sup >) .
|
-
- HY-W031536
-
|
2-Oxoimidazolidine, 96%
|
Biochemical Assay Reagents
|
Others
|
|
2-Imidazolidone, 96% is a chelating agent that forms complexes with metal ions, enabling its use in catalytic processes.
|
-
- HY-W105700
-
|
EDTA sodium hydrate
|
Biochemical Assay Reagents
Bacterial
SOD
|
Cardiovascular Disease
Neurological Disease
Cancer
|
|
Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research .
|
-
- HY-158065
-
-
- HY-W013718
-
|
|
Biochemical Assay Reagents
|
Others
|
|
TTHA is a complexonate with high affinity towards light rare earth elements (LREE), especially for La 3+ in ternary mixtures and Y 3+ in quinary mixtures .
|
-
- HY-W015236R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.
|
-
- HY-W127744
-
-
- HY-W007369A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
BARF (sodium dihydrate) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-Y0682A
-
|
EDTA disodium dihydrate
|
Biochemical Assay Reagents
Bacterial
SOD
|
Cardiovascular Disease
Neurological Disease
Cancer
|
|
Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research .
|
-
- HY-W094712
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Potassium oxalate monohydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-B0658A
-
|
Zinc(II) acetate dihydrate, ACS, 98%
|
Biochemical Assay Reagents
|
Others
|
|
Zinc (acetate dihydrate), ACS, 98% is a metal chelating agent, also used in protein experiments.
|
-
- HY-W008585
-
-
- HY-W127776
-
|
Ethylenediaminetetraacetic acid zinc disodium tetrahydrate
|
Biochemical Assay Reagents
|
Others
|
|
Zn(Ⅱ)-EDTA (Ethylenediaminetetraacetic acid zinc) disodium tetrahydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-111413A
-
|
|
Integrin
|
Cancer
|
|
c(phg-isoDGR-(NMe)k) TFA is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM .
|
-
- HY-W129975
-
|
Boron trioxide,99.98% trace metals basis
|
Biochemical Assay Reagents
|
|
|
Boric anhydride,99.98% trace metals basis (Boron trioxide,99.98% trace metals basis) is a kind of biochemical reagent.
|
-
- HY-107921R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
EDTA Calcium disodium,98% (Standard) is the analytical standard of EDTA Calcium disodium,98%. This product is intended for research and analytical applications. EDTA Calcium disodium, 98% (EDTA calcium disodium salt, 98%; Adsorbonac, 98%) is a chelating agent for calcium and other metal ions, preventing them from participating in chemical reactions. It can effectively remove metal ions from solutions, preventing them from interfering with experimental processes.
|
-
- HY-W018746
-
|
Ethylenediaminetetraacetic acid disodium
|
Biochemical Assay Reagents
|
Others
|
|
EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
|
-
- HY-W115799
-
|
Ethylenediaminetetraacetic acid disodium manganese
|
Biochemical Assay Reagents
|
Others
|
|
Disodium manganese EDTA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W127774
-
|
Ethylenediaminetetraacetic acid hydrate sodium
|
Biochemical Assay Reagents
|
Others
|
|
EDTA (Ethylenediaminetetraacetic acid) hydrate sodium is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W009722A
-
|
Ditiocarb sodium trihydrate, ACS, 99.0%
|
HIV
Biochemical Assay Reagents
|
Infection
|
|
Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%) is a copper reagent. The reaction with Cu 2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer .
|
-
- HY-W127804
-
-
- HY-W073183
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H 2PtCl 6·6H 2O and FeCl 2·4H 2O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .
|
-
- HY-157915
-
|
Tetrakis[3,5-bis(1,1,1,3,3,3-hexafluoro-2-methoxy-2-propyl)phenyl]borate, sodium salt, trihydrate
|
Biochemical Assay Reagents
|
Others
|
|
HFPB (Compound 2) is a type of cation exchanger with high lipophilicity and acid resistivity, which can be used in membrane electrode research .
|
-
- HY-W273209
-
-
- HY-159184
-
-
- HY-W133934A
-
|
|
Biochemical Assay Reagents
|
Others
|
|
EDTA magnesium disodium, 99% is a chelating agent with the ability to effectively bind metal ions (including calcium, magnesium, and iron) and remove them from solution.
|
-
- HY-W127798
-
-
![[S-Methanethiosulfonylcysteaminyl]ethylenediamine-N,N,N',N'-tetraacetic acid](//file.medchemexpress.eu/product_pic/hy-w127798.gif)
- HY-W009048
-
|
DCH18C6; Perhydrodibenzo-18-crown-6
|
Biochemical Assay Reagents
|
Others
|
|
Dicyclohexano-18-crown-6-ether selectively extracts lysine-rich cytochrome c proteins from other cationic proteins under weakly acidic and neutral conditions, demonstrating specificity in ligand-protein interactions .
|
-
- HY-W127835
-
|
Ethylenediaminetetraacetic acid iron sodium hydrate
|
Biochemical Assay Reagents
|
Others
|
|
EDTA iron sodium hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-166984
-
-
- HY-W025784
-
|
Sodium tetraphenylborate; Tetraphenylboron sodium
|
Biochemical Assay Reagents
|
Others
|
|
Kalibor (Sodium tetraphenylborate; Tetraphenylboron sodium) is a precipitating agent, performing a precipitating function in the gravimetric determination of various monovalent cations such as basic organic nitrogen compounds and metal ions .
|
-
- HY-21323
-
-
- HY-157924
-
|
Bis[(benzo-15-crowN-5)-4-methyl]pimelate
|
Biochemical Assay Reagents
|
Others
|
|
Bis(benzo-15-crown-5) (Bis[(benzo-15-crowN-5)-4-methyl]pimelate) is a biochemical assay reagent, and can be used for chemical synthesis .
|
-
- HY-W008948
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Bis(L-tartaric acid) 18-crown-6 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-W009722
-
|
Ditiocarb sodium trihydrate
|
HIV
Biochemical Assay Reagents
|
Infection
|
|
Sodium diethylcarbamodithioate (Ditiocarb sodium) trihydrate is a copper reagent. The reaction with Cu 2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer .
|
-
- HY-W127793
-
|
(S)-1-(p-Bromoacetamidobenzyl)ethylenediaminetetraacetic acid
|
Biochemical Assay Reagents
|
Others
|
|
EDTA-p-Bromoacetamido benzyl ((S)-1-(p-Bromoacetamidobenzyl)ethylenediaminetetraacetic acid) is a compound of EDTA and phenylbromoacetamide that can be coupled to antibodies .
|
-
- HY-W018746R
-
|
|
Biochemical Assay Reagents
|
Others
|
|
EDTA (disodium) (Standard) is the analytical standard of EDTA (disodium). This product is intended for research and analytical applications. EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
|
-
- HY-163966
-
-
- HY-159183
-
-
- HY-W088011B
-
-
- HY-D0850R
-
|
|
Phosphatase
Endogenous Metabolite
|
Cardiovascular Disease
|
|
Tartaric acid (disodium dihydrate) (Standard) is the analytical standard of Tartaric acid (disodium dihydrate). This product is intended for research and analytical applications. Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications [4].
|
-
- HY-W102545
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Diaza-15-crown-5 extends the lifetime of M intermediates in BR membranes. Diaza-15-crown-5 is a crown ether compound that alters the surface charge of BR membranes. Diaza-15-crown-5 changes the surface charge of the BR film. and overall membrane stability. Diaza-15-crown-5 allows the M state to be maintained for a longer period of time .
|
-
- HY-107870
-
-
- HY-W127839
-
|
Ethylenediaminetetraacetic acid dipotassium magnesium
|
Biochemical Assay Reagents
|
Others
|
|
Ethylenediaminetetraacetic acid dipotassium magnesium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-Y0569H
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Magnesium D-gluconate hydrate, 98% is a strong chelating agent that chelates calcium, iron, aluminum, copper, and other heavy metal anions.
|
-
- HY-W134005
-
|
Ethylenediaminetetraacetic acid magnesium disodium tetrahydrate
|
Biochemical Assay Reagents
|
Others
|
|
Mg(II)-EDTA (disodium tetrahydrate) is an ion-chelating agent that can be used to prepare reagents for ion-sensitive experiments .
|
-
- HY-Y0286A
-
|
Carbonic acid (diammonium), 99.999% trace metals basis
|
Biochemical Assay Reagents
|
Others
|
|
Diammonium carbonate, 99.999% trace metals basis is a biochemical reagent and a buffer component .
|
-
- HY-W582564
-
|
Ethylenediaminetetraacetic acid copper disodium tetrahydrate
|
Biochemical Assay Reagents
|
Others
|
|
Cu(Ⅱ)-EDTA disodium tetrahydrate, a typical contaminant in industrial wastewater, is an EDTA-complexed heavy metal. Cu(Ⅱ)-EDTA disodium tetrahydrate can be used in research on the recovery of heavy metal resources from mixed wastewater .
|
-
- HY-W076042
-
|
Sodium tetrakis(4-fluorophenyl)borate dihydrate
|
Biochemical Assay Reagents
|
Others
|
|
Cesibor dihydrate is an additive salt used in ion-selective electrodes (ISEs) and micro ion-selective field effect transistors (μ-ISFETs) to enhance or modulate their selective responses to specific ions .
|
-
- HY-Y0262A
-
|
Ethanedioic acid diammonium monohydrate
|
Endogenous Metabolite
|
Metabolic Disease
|
|
Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
|
-
- HY-157914
-
|
6,6-Dibenzyl-1,4,8,11-tetraoxacyclotetradecane
|
Biochemical Assay Reagents
|
Others
|
|
Dibenzyl-14-crown-4 (6,6-Dibenzyl-1,4,8,11-tetraoxacyclotetradecane) is a crown ether derivate, which serves as neutral carrier in PVC ion-selective electrode, improves the Li + selectivity against Na + and K + .
|
-
- HY-B0988
-
-
- HY-B1625
-
-
- HY-B1005
-
|
8-Quinolinol
|
Bacterial
Antibiotic
|
Cancer
|
|
8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice .
|
-
- HY-W755033
-
|
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
NH2-PEG4-DOTA is a bifunctional, DOTA-type metal chelator. NH2-PEG4-DOTA can be conjugated with Dextran for quantitative analysis in the presence of a highly luminescent complex. NH2-PEG4-DOTA can also bind to radionuclides to prepare radionuclide drug conjugates (RDCs). RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy.
|
-
- HY-120475A
-
|
ATH434 mesylate
|
α-synuclein
|
Neurological Disease
|
|
PBT434 methanesulfonate is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 methanesulfonate can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 methanesulfonate inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 methanesulfonate prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 methanesulfonate has the potential for the research of Parkinson’s disease (PD) .
|
-
- HY-D1637
-
|
|
Fluorescent Dye
|
Others
|
|
5-Nitro BAPTA tetramethyl ester is a calcium chelator. 5-Nitro BAPTA tetramethyl ester involves in the two-photon probe synthesis, and is used for real-time imaging of intracellular calcium ions, calcium waves monitoring at a depth of 100-300 μm in liver tissues for 1100-4000 s. 5-Nitro BAPTA tetramethyl ester, together with fluorescent compound 2-Me-substituted TM, can be used to form a red fluorescent probe (CaTM-2 AM) .
|
-
- HY-164576
-
|
NODA-Bz-SCN
|
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
NCS-MP-NODA (NODA-Bz-SCN) is a bifunctional chelator that can be used to bind to the labeled peptide DK222 with high specificity for PD-L1. The corresponding fluorinated radioactive is synthesized by the aluminum fluoride method, and NCS-MP-NODA targets DK222 to obtain the radioactive analog [18/19F]DK222. [18F]DK222 can quantify PD-L1 in vivo via PET tracking in xenograft models of multiple cancer types.
|
-
- HY-158125
-
|
|
PSMA
|
Cancer
|
|
PSMA binder-2 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-149418
-
|
|
HDAC
Cholinesterase (ChE)
Tau Protein
|
Neurological Disease
|
|
BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.
|
-
- HY-115973
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
AChE-IN-11 (compound 5C) is a triple inhibitor targeting AChE/MAO-B/BACE1 (IC50=7.9 μM, 9.9 μM, 8.3 μM, respectively) and a selective metal ion chelators. AChE-IN-11 exhibits mixed AChE inhibitory effects, binding to both CAS and PAS of AChE. AChE-IN-11 also exhibits good antioxidant activity (ORAC=2.5 eq) and potential neuroprotective effects in Alzheimer's disease .
|
-
- HY-B0988R
-
|
|
Autophagy
HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species
Apoptosis
Akt
|
Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Deferoxamine (mesylate) (Standard) is the analytical standard of Deferoxamine (mesylate). This product is intended for research and analytical applications. Deferoxamine mesylate (Deferoxamine B mesylate) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine mesylate upregulates HIF-1α levels with good antioxidant activity. Deferoxamine mesylate also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine mesylate can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
|
-
- HY-P10781
-
|
|
Radionuclide-Drug Conjugates (RDCs)
PSMA
|
Cancer
|
|
PSMA-D5 has a binding affinity for PSMA with Ki of 0.21 nM and can be used for PSMA tracing after radiolabeling. PSMA-D5 ([ 68Ga]-labeled) contains a DOTA chelator, allowing convenient labeling with therapeutic radionuclides such as 177Lu and 225Ac. PSMA-D5 ([ 68Ga]-labeled) shows excellent pharmacokinetic properties, exhibiting remarkable tumor uptake in 22Rv1 tumors . PSMA-D5 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
|
-
- HY-B1625R
-
|
|
HIF/HIF Prolyl-Hydroxylase
Reactive Oxygen Species
Apoptosis
Akt
Autophagy
|
Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
|
|
Deferoxamine (Standard) is the analytical standard of Deferoxamine. This product is intended for research and analytical applications. Deferoxamine (Deferoxamine B) is an iron chelator (binds to Fe(III) and many other metal cations), is widely used to reduce iron accumulation and deposition in tissues. Deferoxamine upregulates HIF-1α levels with good antioxidant activity. Deferoxamine also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. Deferoxamine can be used in studies of diabetes, neurodegenerative diseases as well as anti-cancer and anti-COVID-19 .
|
-
- HY-156991
-
|
NODA-GA-NHS ester
|
Radionuclide-Drug Conjugates (RDCs)
EGFR
|
Cancer
|
|
NODAGA-NHS (NODA-GA-NHS ester) is a [64]Cu chelator and the dissociated form of DOTA-trastuzumab in vivo. NODAGA-NHS was added in 0.1 M borate buffer at a ratio of 5/20/100 and was able to effectively bind trastuzumab (10 mg/mL) (4°C, 20 h). The copper content of the [64]Cu-NODAGA-trastuzumab was up to 80%. After blood was drawn from the caudal vein of mice, [64]Cu-NODAGA-trastuzumab was injected and showed good tumor uptake in mice expressing HER2 tumors, showing good PET imaging tracking ability.
|
-
- HY-B1005R
-
|
|
Bacterial
Antibiotic
|
Cancer
|
|
8-Hydroxyquinoline (Standard) is the analytical standard of 8-Hydroxyquinoline. This product is intended for research and analytical applications. 8-Hydroxyquinoline (8-Quinolinol) is a lipophilic metal chelator that can be used as a fungicide .8-Hydroxyquinoline shows the MIC range of 27.56-55.11 μM (4-8 μg/mL) against the clinical isolates of Neisseria gonorrhoeae. 8-Hydroxyquinoline can bind to copper form complexes and transport copper into cells. 8-Hydroxyquinoline increases in the number of micronucleated polychromatic erythrocytes and can also make hair depigmented in mice .
|
-
- HY-W087187
-
|
|
Radionuclide-Drug Conjugates (RDCs)
EGFR
|
Cancer
|
|
DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride can be used to label monoclonal antibodies (mAbs) such as trastuzumab (targeting HER2/neu receptor with an affinity of 5.5 nM) under mild conditions (PBS pH 7.4, 25 °C, 30 minutes) after chelation with indium-111. [111In-DOTAGA]-trastuzumab showed a tumor uptake of 65% ID/g in mice bearing breast cancer BT-474 xenografts 72 hours after injection, which is valuable for SPECT/CT imaging and biodistribution studies.
|
-
- HY-163879
-
|
|
Monoamine Oxidase
Reactive Oxygen Species
Ferroptosis
|
Neurological Disease
|
|
hMAO-B-IN-9 (Compound 25c) is a non-competitive inhibitor for monoamine oxidase B (MAO-B) with an IC50 of 1.58 µM (hMAO-B). hMAO-B-IN-9 forms complex with iron ions as a chelator, and inhibits Erastin (HY-15763)-induced ferroptosis. hMAO-B-IN-9 exhibits antioxidant activity by downregulating the level of reactive oxygen species (ROS). hMAO-B-IN-9 improves cognitive function in mice, without significant toxicity (30 mg/kg). hMAO-B-IN-9 is blood-brain barrier permeable, according to the in silico prediction .
|
-
- HY-164575
-
|
|
Radionuclide-Drug Conjugates (RDCs)
PSMA
|
Cancer
|
|
NH2-NODAGA is a NODAGA-type metal chelator that can bind to radionuclides to prepare radionuclide conjugates (RDCs). NH2-NODAGA can react with diethyl squarate in 0.5M phosphate buffer (room temperature, 2 h, pH 7-7.5) to obtain NODAGA.SA. NODAGA.SA can target L-lysine urea-L-glutamate (KuE), which is a key structure of prostate-specific membrane antigen (PSMA). NODAGA.SA.KuE can bind [68]Ga and can be used for PET examination of NMRInu/nu nude mice bearing LNCaP tumors.
|
-
- HY-P10744
-
|
|
Radionuclide-Drug Conjugates (RDCs)
PSMA
|
Cancer
|
|
BQ7859 is a probe targeting PSMA that contains a NOTA chelator and demonstrates excellent imaging performance. BQ7859 can be labeled with various radionuclides, such as 68Ga, 18F, 55Co, and 111In. In a mouse prostate cancer xenograft model, BQ7859 (labeled with 111In) efficiently accumulates in tumor regions in a PSMA-dependent manner and provides high-contrast tumor imaging. BQ7859 shows potential for research in prostate cancer imaging, particularly in positron emission tomography (PET) and single-photon emission computed tomography (SPECT) . BQ7859 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
|
-
- HY-144790
-
|
|
Amyloid-β
Cholinesterase (ChE)
Monoamine Oxidase
|
Neurological Disease
|
|
AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC50s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC50 = 8.8 µM). AChE-IN-12 has remarkable inhibition of self- and Cu 2+-induced Aβ1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease .
|
-
- HY-129200
-
|
|
Endogenous Metabolite
|
Others
|
|
Aspergillomarasmine A is a natural aminopolycarboxylic acid with potent inhibitory activity against class B metallo-β-lactamases (MBLs). Aspergillomarasmine A inactivates MBLs by removing a catalytic Zn2+ cofactor. Aspergillomarasmine A acts as a selective Zn2+ scavenger, promoting the dissociation of the metal cofactor, thereby indirectly inactivating NDM-1. Aspergillomarasmine A causes the loss of Zn2+ ions from the low-affinity binding site of NDM-1. The action of Aspergillomarasmine A results in the rapid degradation of Zn2+-deficient NDM-1, thereby enhancing its potency as a β-lactam enhancer. The mechanism of Aspergillomarasmine A has broad applicability among different Zn2+ chelators .
|
-
- HY-158123
-
|
|
PSMA
|
Cancer
|
|
PSMA binder-1 is a ligand for PSMA and can be used to synthesize Ac-PSMA-trillium. Ac-PSMA-trillium is a suitable PSMA-targeting compound with improved PSMA binding properties and pharmacokinetic properties. PSMA ligands have different biological applications after being modified with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or it can be labeled with 225Ac (to obtain Actinium-225-PSMA-Trillium (BAY 3563254)), which has a radioactive killing effect; it can be used as a Macropa chelator for targeted radionuclide therapy (TRT) , has a strong inhibitory effect on metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-158122
-
|
|
DNA-PK
|
Cancer
|
|
Lys(CO-C3-p-I-Ph)-O-tBu is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules. Lys(CO-C3-p-I-Ph)-O-tBu can increase the residence time of PSMA ligand in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-O-tBu also reduces salivary gland absorption, possibly extending the half-life of the active compound. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-146669
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
BChE-IN-6 (compound 12) is a potent BChE inhibitor, with a Ki of 0.182 μM. BChE-IN-6 shows chelating capacity on Zn 2+. BChE-IN-6 can be used for Alzheimer’s disease (AD) research .
|
-
- HY-158118
-
|
|
DNA-PK
|
Cancer
|
|
Lys(CO-C3-p-I-Ph)-OMe is a pharmacokinetic modifier (PK modifier) that can improve the PK properties of PSMA ligand molecules (such as Ac-PSMA-trillium). Lys(CO-C3-p-I-Ph)-OMe can increase the residence time of Ac-PSMA-trillium in plasma by increasing its binding capacity to albumin. Lys(CO-C3-p-I-Ph)-OMe also reduces salivary gland absorption of Ac-PSMA-trillium, potentially extending its half-life. Ac-PSMA-trillium is a suitable PSMA-targeting compound that has different biological applications after modification with different radioactive isotopes. If labeled with 111In, it can be used as DOTA chelating agent and imaging agent. Or labeled with 225Ac as a Macropa chelator for targeted radionuclide therapy (TRT) in the study of metastatic castration-resistant prostate cancer (mCRPC) .
|
-
- HY-W157376
-
|
|
Bacterial
Antibiotic
Drug Intermediate
|
Infection
Cancer
|
|
PAMAM Dendrimer G0.0 amine is a pore-forming channel antagonist, including anthrax toxin protective antigen 63 (PA63, IC50 = 231 nM) and C. botulinum C2 toxin subunit (C2IIa, IC50 = 940 nM). At concentrations of 10 and 20 µM, PAMAM Dendrimer G0.0 amine reduces C2 toxin-induced death in HeLa cells. Additionally, PAMAM Dendrimer G0.0 amine is a chelator of nickel. In complexes with polysulfone membrane-bound chitosan, PAMAM Dendrimer G0.0 amine selectively captures and stores carbon dioxide (CO2) in a gas-feed system. PAMAM Dendrimer G0.0 amine has been used in the synthesis of PAMAM Dendrimer G0.5 Carboxylate (CAS 339334-01-9) and PAMAM Dendrimer G1.0 Amine (CAS 142986-44-5). PAMAM Dendrimer G0.0 amine can be used in research related to infections, cancer, and drug delivery systems .
|
-
- HY-D1639A
-
-
| Cat. No. |
Product Name |
Type |
-
- HY-D1746
-
|
EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester
|
Fluorescent Dyes/Probes
|
|
EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
|
-
- HY-104058
-
|
Oregon Green 488 BAPTA 1AM
|
Fluorescent Dyes/Probes
|
|
Oregon-BAPTA Green 1AM (Oregon Green 488 BAPTA 1AM) is a fluorescent Ca 2+ indicator that consists of a green fluorescent probe OG 488 and a cell-permeable Ca 2+ chelator BAPTA AM.
|
-
- HY-D0716
-
|
Fluo-3-pentaacetoxymethyl ester
|
Fluorescent Dyes/Probes
|
|
Fluo-3 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-D1498
-
|
|
Fluorescent Dyes/Probes
|
|
Mag-Fluo-4 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-D1641
-
|
|
Fluorescent Dyes/Probes
|
|
5,5'-Dimethyl BAPTA tetrapotassium is a water-soluble, extracellular membrane metal chelator with relative selectivity for calcium ions .
|
-
- HY-D1758
-
|
|
Fluorescent Dyes/Probes
|
|
Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
|
-
- HY-D1759
-
|
|
Fluorescent Dyes/Probes
|
|
Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
|
-
- HY-D1639
-
|
|
Fluorescent Dyes/Probes
|
|
5,5'-Dibromo BAPTA tetrapotassium is a calcium chelator, can be formulated into a buffer with a defined calcium ion concentration. 5,5'-Dibromo BAPTA tetrapotassium can control the concentration of calcium ions inside and outside the cell and can be used in studies of calcium physiological activity .
|
-
- HY-101902
-
|
Quin-2 acetoxymethyl ester
|
Fluorescent Dyes/Probes
|
|
Quin-2AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-D1639A
-
| Cat. No. |
Product Name |
Type |
-
- HY-20512
-
|
|
Chelators
|
|
N,N'-Dibenzylethylenediamine forms chelator with metals. N,N'-Dibenzylethylenediamine interacts with penicillin, forms a stable and tasteless salt of penicillin .
|
-
- HY-100168
-
|
|
Chelators
|
|
BAPTA is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA is widely used as an intracellular buffer for investigating the effects of Ca 2+ release from intracellular stores or influx via Ca 2+-permeable channels in the plasma membrane. BAPTA can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
|
-
- HY-100168B
-
|
|
Chelators
|
|
BAPTA tetrapotassium is a selective chelator for calcium. BAPTA, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca 2+ release from intracellular stores or influx via Ca 2+-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
|
-
- HY-W283556
-
|
|
Chelators
|
|
DO2A-tert-butyl ester is a bifunctional chelator (BFC) that can be used for the coupling of peptides and radionuclides. DO2A-tert-butyl ester can be used in the development of radionuclide imaging tracers .
|
-
- HY-D0861
-
|
|
Chelators
|
|
EGTA is a specific calcium ion chelator. EGTA has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA significantly inhibits the substrate adherence capacity of inflammatory macrophages .
|
-
- HY-158070
-
|
|
Chelators
|
|
Diamsar hydrochloride is a bifunctional chelator .
|
-
- HY-W250574
-
|
NOTA-bis(t-Butyl ester)
|
Chelators
|
|
NOTA-bis(tBu)ester (NOTA-bis(t-Butyl ester)), a NOTA derivative, is a bifunctional chelator that can be used for drug coupling .
|
-
- HY-W088413A
-
|
|
Chelators
|
|
DOTA-amide (dihydrate) is a Bifunctional Chelators (BFCs). DOTA-amide (dihydrate) binds to the Affibody molecule ZHER2:S1. Its complex binds specifically to HER2 and can be used to detect bone metastases, which are common in prostate cancer .
|
-
- HY-138134
-
|
|
Chelators
|
|
NOTPis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NOTP can be used for conjugation of peptides and radionuclides.
|
-
- HY-138269A
-
|
CHX-A''-DTPA-NCS hydrochloride
|
Chelators
|
|
Barzuxetan (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. Barzuxetan (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-134418A
-
|
|
Chelators
|
|
NOTA (trihydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NOTA (trihydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W088413
-
|
|
Chelators
|
|
DOTA-amideis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-amide can be used for conjugation of peptides and radionuclides.
|
-
- HY-W678394
-
|
|
Chelators
|
|
DOTA-Thiolis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-Thiol can be used for conjugation of peptides and radionuclides.
|
-
- HY-158067
-
|
DFO-DBCO
|
Chelators
|
|
Deferoxamine-DBCOis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DFO derivative used for tumor pre-targeting. Deferoxamine-DBCO can be used for conjugation of peptides and radionuclides.
|
-
- HY-W782078
-
|
|
Chelators
|
|
Butyne-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Butyne-DOTA can be used for conjugation of peptides and radionuclides.
|
-
- HY-158072
-
|
|
Chelators
|
|
DOTAM-NHS-esteris a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-NHS-ester can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717743
-
|
|
Chelators
|
|
DOTAM-mono-acidis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-mono-acid can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717830
-
|
|
Chelators
|
|
CB-Cyclamis a bifunctional chelator (Bifunctional Chelator; BFC), which is a main chain Cyclen derivative of the macrocyclic ligand tetradecane. CB-Cyclam can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717782
-
|
|
Chelators
|
|
Bz-DTPA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. Bz-DTPA (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W726767
-
|
|
Chelators
|
|
DO2Ais a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DO2A can be used for conjugation of peptides and radionuclides.
|
-
- HY-W250844A
-
|
|
Chelators
|
|
DO3A (trisodium)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DO3A (trisodium) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W087027A
-
|
|
Chelators
|
|
Maleimide-NOTA (TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. Maleimide-NOTA (TFA) can be used for conjugation of peptides and radionuclides.
|
-
- HY-158077
-
|
(R)-tetraMe-DOTA
|
Chelators
|
|
(R)-tetraMe-Tetraxetanis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. (R)-tetraMe-Tetraxetan can be used for conjugation of peptides and radionuclides.
|
-
- HY-W539916
-
|
|
Chelators
|
|
Azido-mono-amide-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Azido-mono-amide-DOTA can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717779
-
|
|
Chelators
|
|
4-Aminobutyl-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. 4-Aminobutyl-DOTA can be used for conjugation of peptides and radionuclides.
|
-
- HY-158071
-
|
|
Chelators
|
|
p-SCN-Bn-HEHA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-SCN-Bn-HEHA (hydrochloride) can be used for drug conjugation.
|
-
- HY-128890A
-
|
|
Chelators
|
|
DOTA-NHS-ester (hexafluorophosphate TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-NHS-ester (hexafluorophosphate TFA) can be used for conjugation of peptides and radionuclides.
|
-
- HY-A0074
-
|
tetra-tBu-DTPA
|
Chelators
|
|
DTPA-tetra (t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. DTPA-tetra (t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W782087A
-
|
|
Chelators
|
|
p-SCN-Bn-PCTA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-SCN-Bn-PCTA (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W782083
-
|
|
Chelators
|
|
p-SCN-Bn-NOTA (trihydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. p-SCN-Bn-NOTA (trihydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717781A
-
|
|
Chelators
|
|
p-NH?-Bn-DTPA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-NH?-Bn-DTPA (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W782088A
-
|
|
Chelators
|
|
p-NH?-Bn-PCTA (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-NH?-Bn-PCTA (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W802013
-
|
|
Chelators
|
|
DOTA-4AMPis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTA-4AMP can be used for conjugation of peptides and radionuclides.
|
-
- HY-158068
-
|
|
Chelators
|
|
Maleimido-mono-amide-DTPA (TFA)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. Maleimido-mono-amide-DTPA (TFA) can be used for conjugation of peptides and radionuclides.
|
-
- HY-156038
-
|
|
Chelators
|
|
(S)-p-SCN-Bn-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. (S)-p-SCN-Bn-DOTA can be used for conjugation of peptides and radionuclides.
|
-
- HY-W749627
-
|
|
Chelators
|
|
NO2A-Butyneis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NO2A-Butyne can be used for conjugation of peptides and radionuclides.
|
-
- HY-159181
-
|
|
Chelators
|
|
p-NCS-Bz-DOTA-GA is a bifunctional chelator.
|
-
- HY-159180
-
|
|
Chelators
|
|
p-NCS-Bz-NODA-GA is a bifunctional chelator.
|
-
- HY-W451440
-
|
|
Chelators
|
|
Butyne-DOTA-tris(t-butyl ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Butyne-DOTA-tris(t-butyl ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-131673A
-
|
|
Chelators
|
|
(S)-p-SCN-Bn-TCMC (hydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. (S)-p-SCN-Bn-TCMC (hydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717800A
-
|
|
Chelators
|
|
NO2A-Azide (trihydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NO2A-Azide (trihydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-156138A
-
|
|
Chelators
|
|
CB-TE2A (tetrahydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC), which is a TETA derivative of the macrocyclic ligand tetradecane backbone. CB-TE2A (tetrahydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717833
-
|
|
Chelators
|
|
NO2A-(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NO2A-(t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W782075
-
|
|
Chelators
|
|
p-NO2-Bn-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NO2-Bn-DOTA can be used for conjugation of peptides and radionuclides.
|
-
- HY-48876
-
|
|
Chelators
|
|
p-NH2-Bn-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NH2-Bn-DOTA can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717742
-
|
|
Chelators
|
|
p-NO2-Bn-Cyclenis a bifunctional chelator (Bifunctional Chelator; BFC), which is a derivative of the macrocyclic ligand dodecane backbone Cyclen. p-NO2-Bn-Cyclen can be used for conjugation of peptides and radionuclides.
|
-
- HY-158069
-
|
|
Chelators
|
|
p-NH?-Bn-DTPA-penta (t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-NH?-Bn-DTPA-penta (t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W460274
-
|
|
Chelators
|
|
4-Aminobutyl-DOTA-tris(t-butyl ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. 4-Aminobutyl-DOTA-tris(t-butyl ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-158066
-
|
|
Chelators
|
|
p-NH2-Bn-NOTA (hydrochloride hydrate)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. p-NH2-Bn-NOTA (hydrochloride hydrate) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W250929
-
|
|
Chelators
|
|
Maleimido-mono-amide-DOTA-tris(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Maleimido-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
- HY-148646A
-
|
|
Chelators
|
|
p-NH2-CHX-A"-DTPA (hydrochloride hydrate)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DPTA derivative used for tumor pre-targeting. p-NH2-CHX-A"-DTPA (hydrochloride hydrate) can be used for conjugation of peptides and radionuclides.
|
- HY-124452
-
|
Desferrioxamine E; Nocardamin
|
Chelators
|
|
Nocardamine (Deferrioxamine E)is an iron carrier/Iron chelator with antimicrobial activity .
|
- HY-W749603
-
|
|
Chelators
|
|
Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Fmoc-L-Lys-mono-amide-DOTA-tris(t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
- HY-W749614
-
|
|
Chelators
|
|
NO2A-Butyne-bis(t-Butyl ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NO2A-Butyne-bis(t-Butyl ester) can be used for conjugation of peptides and radionuclides.
|
- HY-W782081
-
|
|
Chelators
|
|
p-SCN-Bn-oxo-DO3Ais a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-SCN-Bn-oxo-DO3A can be used for conjugation of peptides and radionuclides.
|
- HY-W717760
-
|
|
Chelators
|
|
p-NH2-Bn-DOTA-tetra(t-Bu ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NH2-Bn-DOTA-tetra(t-Bu ester) can be used for conjugation of peptides and radionuclides.
|
- HY-W782080
-
|
|
Chelators
|
|
p-NH2-Bn-oxo-DO3Ais a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. p-NH2-Bn-oxo-DO3A can be used for conjugation of peptides and radionuclides.
|
- HY-W102590
-
|
|
Chelators
|
|
DOTMP is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
- HY-W004649
-
|
|
Chelators
|
|
Tris-BOC-cyclen is a bifunctional chelator. Bifunctional chelating agentscan be used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
- HY-W402032
-
|
|
Chelators
|
|
Bis-Cbz-cyclen is a bifunctional chelator. Bifunctional chelating agents are used to stably link the radiometal to the carrier moiety of the radiopharmaceutical .
|
- HY-45290
-
|
|
Chelators
|
|
trans-1,2-Cyclohexanediaminetetraacetic acid is a commonly used aminopolycarboxylic acid and a strong chelator of heavy metal ions .
|
- HY-100133A
-
|
|
Chelators
|
|
DOTA-ADIBO TFA is a DOTA-derived bifunctional chelator (BFC) that allows drug conjugation via an uncatalyzed, copper-free cycloaddition reaction. DOTA-ADIBO TFA enables the construction of fusion chelator systems that can be further used to synthesize radiotracers after Cu[64] modification. Positron emission tomography imaging of tumors expressing integrin αvβ6 .
|
- HY-D0973
-
EGTA-AM
5 Publications Verification
EGTA Acetoxymethyl ester
|
Chelators
|
|
EGTA-AM is a membrane permeable form of EGTA, can be passively loaded into cells to generate intracellular EGTA; EGTA-AM is also a Ca 2+ chelator with slow chelating dynamics.
|
- HY-D0861A
-
|
|
Biochemical Assay Reagents
|
|
EGTA tetrasodium is a specific calcium ion chelator. EGTA tetrasodium has an apparent calcium dissociation constant (Kd) of 60.5 nM at physiological pH (7.4) and has very high specificity for Ca 2+ over Mg 2+ (Mg 2+ Kd 1-10 mM). EGTA tetrasodium significantly inhibits the substrate adherence capacity of inflammatory macrophages .
|
- HY-W004544
-
|
1,10-Phenanthroline
|
Chelators
|
|
o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe 2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor .
|
- HY-100545
-
BAPTA-AM
Maximum Cited Publications
73 Publications Verification
|
Chelators
|
|
BAPTA-AM is a well-known membrane permeable Ca 2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively .
|
- HY-D0836
-
|
Ethylenediaminetetraacetic acid dipotassium dihydrate
|
Chelators
|
|
EDTA dipotassium dihydrate is a metal ion chelator that forms stable and water-soluble chelates with a variety of metal ions. EDTA dipotassium is commonly used as a blood anticoagulant, which can effectively prevent blood coagulation and maintain the morphology and function of cells in blood samples. In the industrial field, EDTA dipotassium can be used to remove the adverse effects of metal ions and prevent oxidation and deterioration caused by metal ions .
|
- HY-W017165
-
|
|
Biochemical Assay Reagents
|
|
Sodium malonate hydrate is a complexing agent for the determination of beryllium and copper. Sodium malonate hydrate is a kind of biological materials or organic compounds that are widely used in life science research .
|
- HY-D0855
-
- HY-W094510
-
|
|
Buffer Reagents
|
|
Sodium pyrophosphate decahydrate can be as a buffering agent, a chelator and a hydrated salt nucleating agent. Sodium pyrophosphate decahydrate can also be used to a raw material for synthetic laundry scent additives .
|
- HY-W012898
-
|
Biacetyl dioxime
|
Biochemical Assay Reagents
|
|
Dimethylglyoxime (Biacetyl dioxime) belongs to the class of oximes and consists of two acetyl groups attached to a nitrogen atom, which in turn is attached to another nitrogen atom through a diimine bond. Dimethylglyoxime is a specific chelator of Ni that inhibits or slows the aggregation of Aβ peptides in vitro .
|
- HY-W035520
-
|
|
Biochemical Assay Reagents
|
|
HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy .
|
- HY-Y1841
-
|
1,10-Phenanthroline monohydrate
|
Biochemical Assay Reagents
|
|
o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe 2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor .
|
- HY-W011060
-
|
4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane
|
Biochemical Assay Reagents
|
|
Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn 2+, Co 2+, Ni 2+, Cu 2+) .
|
- HY-W111692
-
|
|
Surfactants
|
|
Sodium polyphosphate, crystal, +200 mesh, 96% is a water-soluble inorganic stabilizer with surfactant and metal ion chelator activity. Sodium polyphosphate, crystal, +200 mesh, 96% can be widely used in food, cosmetics and industrial products to improve product texture and stability. Sodium polyphosphate, crystal, +200 mesh, 96% also helps prevent metal ion-induced degradation and extend the product's life.
|
- HY-W011060R
-
|
|
Biochemical Assay Reagents
|
|
Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2. This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelator that can be used as a reducing agent and stabilizer to prepare nanoparticles. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn2+, Co2+, Ni2+, Cu2+) .
|
- HY-40309
-
|
|
Chelators
|
|
Dibenzo-18-crown-6 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W127836
-
|
(S)-1-(4-Aminoxyacetamidobenzyl)ethylenediaminetetraacetic acid
|
Chelators
|
|
(S)-1-(4-Aminoxyacetamidobenzyl)ethylenediaminetetraacetic Acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W052750
-
|
|
Chelators
|
|
5-Carboxy-2-thiouracil is a compound with antitumor activity that can form complexes with metal ions, thereby exhibiting significant biological effects.
|
- HY-131926R
-
|
|
Chelators
|
|
EDTA (iron sodium) (Standard) is the analytical standard of EDTA (iron sodium). This product is intended for research and analytical applications. EDTA iron sodium (NaFeEDTA; Sodium iron EDTA) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-Y0682R
-
|
|
Chelators
|
|
Ethylenediaminetetraacetic acid (Standard) is the analytical standard of Ethylenediaminetetraacetic acid. This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research [4] .
|
- HY-W128312
-
|
1,3-DAPTA
|
Chelators
|
|
1,3-Diaminopropane-N,N,N',N'-tetraacetic acid (1,3-DAPTA) is a kind of biochemical reagent.
|
- HY-W109973
-
|
L-(+)-Tartaric acid diammonium
|
Chelators
|
|
L-Tartaric acid diammonium (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. L-Tartaric acid diammonium has vasodilatory and antihypertensive effects. L-Tartaric acid diammonium can be used as flavorings and antioxidants in a range of foods and beverages. L-Tartaric acid diammonium can be used in laser frequency doubling and optical limiting applications .
|
- HY-W004650
-
|
|
Chelators
|
|
TETA hydrochloride hydrate is an effective selective chelating agent for copper (II). TETA hydrochloride hydrate can be used for drug coupling .
|
- HY-Y0262B
-
|
Ethanedioic acid (sodium),ACS, 99.5%
|
Chelators
|
|
Sodium oxalate,ACS,99.5% (Ethanedioic acid (sodium),ACS, 99.5%) is a biochemical assay reagent.
|
- HY-Y0682
-
|
EDTA
|
Chelators
|
|
Ethylenediaminetetraacetic acid (EDTA) is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid can be used for coronary artery disease and neural system disease research .
|
- HY-W555991
-
|
|
Chelators
|
|
2',3'-O-Isopropylidene-6-mercaptopurine riboside is a compound with excellent metal complexing activity. 2',3'-O-Isopropylidene-6-mercaptopurine riboside can be used to study the mechanism of metal complexing.
|
- HY-W011425A
-
|
Nitrilotris(methylenephosphonic acid), trisodium salt
|
Chelators
|
|
NTPO trisodium is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO trisodium are abrogated by base excision repair (BER) but not nucleotide excision repair (NER) .
|
- HY-W087947
-
|
Ethylenediaminetetraacetic acid dihydrate tripotassium
|
Chelators
|
|
EDTA·2H2O (tripotassium) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-21323R
-
|
|
Chelators
|
|
Isophthalic acid (Standard) is the analytical standard of Isophthalic acid. This product is intended for research and analytical applications. Isophthalic acid is a kind of biological materials or organic compounds that are widely used in life science research .
|
- HY-W127831
-
|
|
Chelators
|
|
2-Aminomethyl-15-crown-5 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W105875
-
|
D-Gluconic acid iron(II) salt dihydrate, 98%
|
Chelators
|
|
Iron(II) D-gluconate dihydrate, 98% is used for blood coagulation.
|
- HY-W103245
-
|
B18C6
|
Chelators
|
|
Benzo-18-crown-6-ether (B18C6) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K +; when Mg 2+ ions are present, 18-Crown-6-ether and K + ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load .
|
- HY-W106012
-
|
|
Chelators
|
|
Aluminum sulfate hexadecahydrate is a kind of biochemical reagent.
|
- HY-W691498
-
|
|
Chelators
|
|
Sodiumα-glucoheptonate, 97% is a multifunctional chelating agent capable of forming stable complexes with various metal ions.
|
- HY-W108801
-
|
|
Chelators
|
|
α-D-Glucoheptonic acid sodium is a compound that modulates the immune system, has chelating activity, and can be used in the preparation of cleaning agents.
|
- HY-163966R
-
|
|
Chelators
|
|
Decarboxyl ofloxacin (Standard) is the analytical standard of Decarboxyl ofloxacin. This product is intended for research and analytical applications. (±)-myo-Inositol-1-phosphate is a biochemical assay reagent.
|
- HY-131926
-
|
Ethylenediaminetetraacetic acid iron sodium
|
Chelators
|
|
EDTA iron sodium (NaFeEDTA; Sodium iron EDTA) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-167181
-
|
|
Chelators
|
|
1,1′-Bis(phenylphosphino)ferrocene is a biochemical reagent.
|
- HY-111413
-
|
|
Chelators
|
|
c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM .
|
- HY-W013851
-
|
|
Chelators
|
|
EDTA-OH is a chelating agent, which forms thermodynamically stable chelates with metal ions like calcium, magnesium, iron, zinc and copper . EDTA-OH exhibits ability of phytoremediation in heavy-metal-contaminated soils . EDTA-OH is able to cross brain-blood barrier .
|
- HY-D0850
-
|
Sodium tartrate dibasic dihydrate; Sodium tartrate dihydrate
|
Chelators
|
|
Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications .
|
- HY-W539893
-
|
NODAG
|
Chelators
|
|
NODAGA-tris(t-Bu ester) (NODAG) is a NODAGA derivative. NODAGA-tris(t-Bu ester) can be used to label peptides, antibodies, etc., and subsequently radiolabeled for PET imaging .
|
- HY-W015236
-
|
Triglycine
|
Chelators
|
|
H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.
|
- HY-W031536R
-
|
|
Chelators
|
|
2-Imidazolidone, 96% (Standard) is the analytical standard of 2-Imidazolidone, 96%. This product is intended for research and analytical applications. 2-Imidazolidone, 96% is a chelating agent that forms complexes with metal ions, enabling its use in catalytic processes.
|
- HY-107921
-
|
EDTA calcium disodium salt,98%; Adsorbonac,98%
|
Chelators
|
|
EDTA Calcium disodium, 98% (EDTA calcium disodium salt, 98%; Adsorbonac, 98%) is a chelating agent for calcium and other metal ions, preventing them from participating in chemical reactions. It can effectively remove metal ions from solutions, preventing them from interfering with experimental processes.
|
- HY-B0812
-
|
SSA dihydrate
|
Chelators
|
|
5-Sulfosalicylic acid dihydrate is a sulfonated salicylic acid derivative. 5-Sulfosalicylic acid dihydrate is effective against the breast cancer cell line, MCF-7, with less toxicity . 5-Sulfosalicylic acid dihydrate has antioxidant activities .
|
- HY-W008951
-
|
EDTMP
|
Chelators
|
|
Ethylenediaminetetra(methylenephosphonic acid) (EDTMP) is a biochemical assay reagent.
|
- HY-W127744R
-
|
|
Chelators
|
|
Chlorophyll a (Standard) is the analytical standard of Chlorophyll a. This product is intended for research and analytical applications. Chlorophyll a is a plant extract.
|
- HY-W127802
-
|
(Rac)-(Bromoacetamidophenylmethyl)ethylenediaminetetraacetic acid
|
Chelators
|
|
(Rac)-EDTA-bromoacetamidophenylmethyl is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-Y0682AR
-
|
|
Chelators
|
|
Ethylenediaminetetraacetic acid (disodium dihydrate) (Standard) is the analytical standard of Ethylenediaminetetraacetic acid (disodium dihydrate). This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research [4] .
|
- HY-W111522
-
|
di-Sodium hydrogen phosphite, 98%
|
Chelators
|
|
Sodium phosphite dibasic pentahydrate, 98% is a metal chelating agent used to remove copper ions from water supplies.
|
- HY-W140537
-
|
|
Chelators
|
|
EDTA diammonium salt hydrate, 97% is a derivative of ethylenediaminetetraacetic acid (EDTA), commonly used as a chelating agent in various applications due to its ability to bind with various metal ions and form stable complexes.
|
- HY-W008563
-
|
|
Chelators
|
|
Bapta tetraethyl ester is a kind of biochemical reagent.
|
- HY-W749867
-
|
Calcium disodium EDTA dihydrate
|
Chelators
|
|
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning .
|
- HY-157917
-
|
|
Chelators
|
|
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .
|
- HY-W007451
-
|
|
Chelators
|
|
15-Crown-5 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W127779
-
|
|
Chelators
|
|
Deferasirox iron complex is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W130354
-
|
|
Chelators
|
|
Cucurbituril is a container molecule resembling a hollow pumpkin, with two identical inlets at each end and a hydrophobic cavity in the middle. Cucurbiturils have unique chemical properties that allow them to selectively encapsulate guest molecules such as drugs or catalysts within their cavities, shielding them from the surrounding environment. Cucurbituril has important potential applications in various fields such as drug delivery, catalysis and materials science.
|
- HY-W025784R
-
|
|
Chelators
|
|
Kalibor (Standard) is the analytical standard of Kalibor. This product is intended for research and analytical applications. Kalibor (Sodium tetraphenylborate; Tetraphenylboron sodium) is a precipitating agent, performing a precipitating function in the gravimetric determination of various monovalent cations such as basic organic nitrogen compounds and metal ions .
|
- HY-W004563
-
|
|
Chelators
|
|
Neocuproine is an organic compound commonly used as a complexing reagent and copper ion detector. It can form stable complexes with copper ions, and can play a catalytic role in certain chemical reactions and analytical methods. In addition, this compound is also widely used in some biomedical fields, such as in the study of copper metabolism disorders and neurodegenerative diseases
|
- HY-W127785R
-
|
|
Chelators
|
|
N-ethyl-N-oxido-dodecan-1-amine (Standard) is the analytical standard of N-ethyl-N-oxido-dodecan-1-amine. This product is intended for research and analytical applications. N-ethyl-N-oxido-dodecan-1-amine is an amine oxide surfactant commonly used as a detergent, emulsifier and wetting agent in various industrial processes, especially in personal care products and household cleaning in the production of agents. N,N-Dimethyldodecylamine N-oxide has unique chemical properties that make it an effective ingredient in many product formulations to help reduce surface tension and enhance cleaning power.
|
- HY-W127785
-
|
N,N-Dimethyldodecylamine N-oxide; Dodecyldimethylamine oxide
|
Chelators
|
|
N-ethyl-N-oxido-dodecan-1-amine is an amine oxide surfactant commonly used as a detergent, emulsifier and wetting agent in various industrial processes, especially in personal care products and household cleaning in the production of agents. N,N-Dimethyldodecylamine N-oxide has unique chemical properties that make it an effective ingredient in many product formulations to help reduce surface tension and enhance cleaning power.
|
- HY-D0180
-
|
18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane
|
Chelators
|
|
18-Crown-6-ether (18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane) is an organic compound that can be used to prepare stable microcapsule responsive layers for further assembly into bilayer microcapsules. For example, 18-Crown-6-ether is used to prepare the response layer and is coated with a G-quadruplex cross-linked hydrogel layer stabilized by K +; when Mg 2+ ions are present, 18-Crown-6-ether and K + ions can respectively Dissociates and locks with the G-quadruplex cross-linked layer, thereby achieving switchable controlled release of the load .
|
- HY-157926
-
|
|
Chelators
|
|
Nitroso-PSAP is a sensitive and specific chromogenic reagent for iron (Fe 2+), which is used for the colorimetric determination of iron in blood after mineralization with periodic acid. TNitroso-PSAP chelates with iron (Fe 2+) to produce a green complex (λmax=756 nm, Epsilon = 4.5 x 10 < sup > 4 < / sup > dm < sup > 3 < / sup > mol < sup > 1 < / sup > cm < sup > 1 < / sup >) .
|
- HY-W031536
-
|
2-Oxoimidazolidine, 96%
|
Chelators
|
|
2-Imidazolidone, 96% is a chelating agent that forms complexes with metal ions, enabling its use in catalytic processes.
|
- HY-W105700
-
|
EDTA sodium hydrate
|
Chelators
|
|
Ethylenediaminetetraacetic acid (EDTA) sodium hydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid sodium hydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid sodium hydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid sodium hydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid sodium hydrate can be used for coronary artery disease and neural system disease research .
|
- HY-158065
-
|
|
Chelators
|
|
Azido-mono-amide-DOTA-tris(t-Bu ester) is a biochemical assay reagent, and is a click chemistry reagent .
|
- HY-W013718
-
|
|
Chelators
|
|
TTHA is a complexonate with high affinity towards light rare earth elements (LREE), especially for La 3+ in ternary mixtures and Y 3+ in quinary mixtures .
|
- HY-W015236R
-
|
|
Chelators
|
|
H-Gly-Gly-Gly-OH (Standard) is the analytical standard of H-Gly-Gly-Gly-OH. This product is intended for research and analytical applications. H-Gly-Gly-Gly-OH, also known as Triglycine, is a tripeptide composed of glycine, glycine and glycine, which are linked by peptide bonds. Often used as a model compound in the study of protein structure and function. Glycylglycylglycine also acts as a neurotransmitter in the central nervous system and has been shown to have antioxidant properties. Furthermore, it may have potential research roles in various diseases such as cancer, diabetes and neurodegenerative diseases.
|
- HY-W127744
-
- HY-W007369A
-
|
|
Chelators
|
|
BARF (sodium dihydrate) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
- HY-Y0682A
-
|
EDTA disodium dihydrate
|
Chelators
|
|
Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research .
|
- HY-W094712
-
|
|
Chelators
|
|
Potassium oxalate monohydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-B0658A
-
|
Zinc(II) acetate dihydrate, ACS, 98%
|
Chelators
|
|
Zinc (acetate dihydrate), ACS, 98% is a metal chelating agent, also used in protein experiments.
|
- HY-W008585
-
|
B15C5
|
Chelators
|
|
Benzo-15-crown-5-ether can be used as a chelating agent for sodium and potassium .
|
- HY-W127776
-
|
Ethylenediaminetetraacetic acid zinc disodium tetrahydrate
|
Chelators
|
|
Zn(Ⅱ)-EDTA (Ethylenediaminetetraacetic acid zinc) disodium tetrahydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-111413A
-
|
|
Chelators
|
|
c(phg-isoDGR-(NMe)k) TFA is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM .
|
- HY-W129975
-
|
Boron trioxide,99.98% trace metals basis
|
Chelators
|
|
Boric anhydride,99.98% trace metals basis (Boron trioxide,99.98% trace metals basis) is a kind of biochemical reagent.
|
- HY-107921R
-
|
|
Chelators
|
|
EDTA Calcium disodium,98% (Standard) is the analytical standard of EDTA Calcium disodium,98%. This product is intended for research and analytical applications. EDTA Calcium disodium, 98% (EDTA calcium disodium salt, 98%; Adsorbonac, 98%) is a chelating agent for calcium and other metal ions, preventing them from participating in chemical reactions. It can effectively remove metal ions from solutions, preventing them from interfering with experimental processes.
|
- HY-W018746
-
|
Ethylenediaminetetraacetic acid disodium
|
Chelators
|
|
EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
|
- HY-W115799
-
|
Ethylenediaminetetraacetic acid disodium manganese
|
Chelators
|
|
Disodium manganese EDTA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W127774
-
|
Ethylenediaminetetraacetic acid hydrate sodium
|
Chelators
|
|
EDTA (Ethylenediaminetetraacetic acid) hydrate sodium is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W009722A
-
|
Ditiocarb sodium trihydrate, ACS, 99.0%
|
Chelators
|
|
Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% (Ditiocarb sodium trihydrate, ACS, 99.0%) is a copper reagent. The reaction with Cu 2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate, ACS, 99.0% can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer .
|
- HY-W127804
-
|
|
Chelators
|
|
Tetraacetoxymethyl bis(2-aminoethyl) ether N,N,N',N'-tetraacetic acid is a biochemical reagent.
|
- HY-W073183
-
|
|
Chelators
|
|
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H 2PtCl 6·6H 2O and FeCl 2·4H 2O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .
|
- HY-157915
-
|
Tetrakis[3,5-bis(1,1,1,3,3,3-hexafluoro-2-methoxy-2-propyl)phenyl]borate, sodium salt, trihydrate
|
Chelators
|
|
HFPB (Compound 2) is a type of cation exchanger with high lipophilicity and acid resistivity, which can be used in membrane electrode research .
|
- HY-W273209
-
|
|
Chelators
|
|
Pentamethoxy red is a kind of biochemical reagent.
|
- HY-159184
-
|
|
Chelators
|
|
THP-Mal is a biochemical assay reagent.
|
- HY-W133934A
-
|
|
Chelators
|
|
EDTA magnesium disodium, 99% is a chelating agent with the ability to effectively bind metal ions (including calcium, magnesium, and iron) and remove them from solution.
|
- HY-W127798
-
|
|
Chelators
|
|
[S-Methanethiosulfonylcysteaminyl]ethylenediamine-N,N,N',N'-tetraacetic acid is a biochemical assay reagent.
|
- HY-W009048
-
|
DCH18C6; Perhydrodibenzo-18-crown-6
|
Chelators
|
|
Dicyclohexano-18-crown-6-ether selectively extracts lysine-rich cytochrome c proteins from other cationic proteins under weakly acidic and neutral conditions, demonstrating specificity in ligand-protein interactions .
|
- HY-W127835
-
|
Ethylenediaminetetraacetic acid iron sodium hydrate
|
Chelators
|
|
EDTA iron sodium hydrate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-166984
-
|
|
Chelators
|
|
Phytic acid (calcium) is a biochemical assay reagent.
|
- HY-W025784
-
|
Sodium tetraphenylborate; Tetraphenylboron sodium
|
Chelators
|
|
Kalibor (Sodium tetraphenylborate; Tetraphenylboron sodium) is a precipitating agent, performing a precipitating function in the gravimetric determination of various monovalent cations such as basic organic nitrogen compounds and metal ions .
|
- HY-21323
-
|
|
Chelators
|
|
Isophthalic acid is a kind of biological materials or organic compounds that are widely used in life science research .
|
- HY-157924
-
|
Bis[(benzo-15-crowN-5)-4-methyl]pimelate
|
Chelators
|
|
Bis(benzo-15-crown-5) (Bis[(benzo-15-crowN-5)-4-methyl]pimelate) is a biochemical assay reagent, and can be used for chemical synthesis .
|
- HY-W008948
-
|
|
Chelators
|
|
Bis(L-tartaric acid) 18-crown-6 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-W009722
-
|
Ditiocarb sodium trihydrate
|
Chelators
|
|
Sodium diethylcarbamodithioate (Ditiocarb sodium) trihydrate is a copper reagent. The reaction with Cu 2+ solution resulted in the formation of a complex, which increased the copper displacement precipitation rate. Sodium diethylcarbamodithioate trihydrate can reduce HIV infection and can be used in adjuvant immune research of high-risk breast cancer .
|
- HY-W127793
-
|
(S)-1-(p-Bromoacetamidobenzyl)ethylenediaminetetraacetic acid
|
Chelators
|
|
EDTA-p-Bromoacetamido benzyl ((S)-1-(p-Bromoacetamidobenzyl)ethylenediaminetetraacetic acid) is a compound of EDTA and phenylbromoacetamide that can be coupled to antibodies .
|
- HY-W018746R
-
|
|
Chelators
|
|
EDTA (disodium) (Standard) is the analytical standard of EDTA (disodium). This product is intended for research and analytical applications. EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.
|
- HY-163966
-
|
|
Chelators
|
|
(±)-myo-Inositol-1-phosphate is a biochemical assay reagent.
|
- HY-159183
-
|
|
Chelators
|
|
THP-NCS is a biochemical assay reagent.
|
- HY-W088011B
-
|
Sodium hydroxyacetate, 98%
|
Chelators
|
|
Sodium glycolate, 98% is a metal chelating agent.
|
- HY-D0850R
-
|
|
Chelators
|
|
Tartaric acid (disodium dihydrate) (Standard) is the analytical standard of Tartaric acid (disodium dihydrate). This product is intended for research and analytical applications. Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications [4].
|
- HY-W102545
-
|
|
Chelators
|
|
Diaza-15-crown-5 extends the lifetime of M intermediates in BR membranes. Diaza-15-crown-5 is a crown ether compound that alters the surface charge of BR membranes. Diaza-15-crown-5 changes the surface charge of the BR film. and overall membrane stability. Diaza-15-crown-5 allows the M state to be maintained for a longer period of time .
|
- HY-107870
-
|
|
Chelators
|
|
1,2,4-Triazole-3-carboxylic acid, 97% is a biochemical assay reagent.
|
- HY-W127839
-
|
Ethylenediaminetetraacetic acid dipotassium magnesium
|
Chelators
|
|
Ethylenediaminetetraacetic acid dipotassium magnesium salt is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
- HY-Y0569H
-
|
|
Chelators
|
|
Magnesium D-gluconate hydrate, 98% is a strong chelating agent that chelates calcium, iron, aluminum, copper, and other heavy metal anions.
|
- HY-W134005
-
|
Ethylenediaminetetraacetic acid magnesium disodium tetrahydrate
|
Chelators
|
|
Mg(II)-EDTA (disodium tetrahydrate) is an ion-chelating agent that can be used to prepare reagents for ion-sensitive experiments .
|
- HY-Y0286A
-
|
Carbonic acid (diammonium), 99.999% trace metals basis
|
Chelators
|
|
Diammonium carbonate, 99.999% trace metals basis is a biochemical reagent and a buffer component .
|
- HY-W582564
-
|
Ethylenediaminetetraacetic acid copper disodium tetrahydrate
|
Chelators
|
|
Cu(Ⅱ)-EDTA disodium tetrahydrate, a typical contaminant in industrial wastewater, is an EDTA-complexed heavy metal. Cu(Ⅱ)-EDTA disodium tetrahydrate can be used in research on the recovery of heavy metal resources from mixed wastewater .
|
- HY-W076042
-
|
Sodium tetrakis(4-fluorophenyl)borate dihydrate
|
Chelators
|
|
Cesibor dihydrate is an additive salt used in ion-selective electrodes (ISEs) and micro ion-selective field effect transistors (μ-ISFETs) to enhance or modulate their selective responses to specific ions .
|
- HY-Y0262A
-
|
Ethanedioic acid diammonium monohydrate
|
Chelators
|
|
Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
|
- HY-157914
-
|
6,6-Dibenzyl-1,4,8,11-tetraoxacyclotetradecane
|
Chelators
|
|
Dibenzyl-14-crown-4 (6,6-Dibenzyl-1,4,8,11-tetraoxacyclotetradecane) is a crown ether derivate, which serves as neutral carrier in PVC ion-selective electrode, improves the Li + selectivity against Na + and K + .
|
- HY-D1639A
-
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P10137
-
|
JR11
|
Somatostatin Receptor
|
Cancer
|
|
Satoreotide (JR11) is a SSTR2 antagonist. Satoreotide is usually conjugated with radiolabeled chelators used in neuroendocrine tumor imaing .
|
-
- HY-P10273A
-
|
|
Radionuclide-Drug Conjugates (RDCs)
Biochemical Assay Reagents
|
Cancer
|
|
DOTA-Octreotide TFA is composed of chelator DOTA and Octreotide (HY-P0036). DOTA-Octreotide TFA is used for research of cancer through combination with radioactive elements. DOTA-Octreotide TFA can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .
|
-
- HY-P6351
-
|
|
Integrin
|
Cancer
|
|
c(avb6)-DOTA TFA is a conjugate of the αvβ6 integrin selective peptide ring modified with DOTA chelator. The Lu(III) complex of c(avb6)-DOTA TFA has a comparable affinity for αvβ6 integrin (IC50=0.8 nM) and can be used as a tumor diagnostic .
|
-
- HY-P10253
-
|
|
Peptides
|
Others
|
|
Homo-phytochelatin is heavy metal chelator presented in legumes .
|
-
- HY-P10273
-
-
- HY-W005561
-
|
|
Amino Acid Derivatives
|
Others
|
|
H-Dab(Boc)-OMe hydrochloride is an N-terminally protected diaminobutyric acid containing two protecting groups: methoxy (OMe) and tert-butyloxycarbonyl (Boc). H-Dab(Boc)-OMe hydrochloride can be used to synthesize the bifunctional chelator H3Dpaa that can rapidly complex 68Ga under physiological conditions .
|
-
- HY-P10846
-
|
|
Isotope-Labeled Compounds
|
Cardiovascular Disease
|
|
HYNIC-CTP is a conjugate of HYNIC and CTP (cardiac-targeting peptide). HYNIC-CTP can bind with the radionuclide 99mTc through HYNIC acting as a chelator, forming 99mTc-HYNIC-CTP. 99mTc-HYNIC-CTP is specifically taken up by the heart and used for cardiac imaging, thereby facilitating research into heart diseases .
|
-
- HY-P10743
-
|
|
Radionuclide-Drug Conjugates (RDCs)
PSMA
|
Cancer
|
|
BQ7876 is a probe targeting prostate-specific membrane antigen (PSMA) that contains a DOTA chelator. BQ7876, after being radiolabeled with radionuclide (177Lu), functions in both radionuclide imaging and tumor cell destruction by specifically binding to PSMA. BQ7876 shows potential for research in the field of metastatic castration-resistant prostate cancer (mCRPC) . BQ7876 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
|
-
- HY-P10913
-
|
|
Bacterial
|
Infection
|
|
HYNIC-UBI29-41 is composed of a bifunctional chelator HYNIC and an antimicrobial peptide UBI 29-41. HYNIC-UBI29-41 retains the antibacterial properties of UBI 29-41, and exhibits good affinity to Gram-positive and Gram-negative bacteria. HYNIC-UBI29-41 can be used as an imaging agent for bacterial infection detection in mouse models, when labeled with the radioactive element technetium (99mTc) .
|
-
- HY-P10781
-
|
|
Radionuclide-Drug Conjugates (RDCs)
PSMA
|
Cancer
|
|
PSMA-D5 has a binding affinity for PSMA with Ki of 0.21 nM and can be used for PSMA tracing after radiolabeling. PSMA-D5 ([ 68Ga]-labeled) contains a DOTA chelator, allowing convenient labeling with therapeutic radionuclides such as 177Lu and 225Ac. PSMA-D5 ([ 68Ga]-labeled) shows excellent pharmacokinetic properties, exhibiting remarkable tumor uptake in 22Rv1 tumors . PSMA-D5 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
|
-
- HY-P10744
-
|
|
Radionuclide-Drug Conjugates (RDCs)
PSMA
|
Cancer
|
|
BQ7859 is a probe targeting PSMA that contains a NOTA chelator and demonstrates excellent imaging performance. BQ7859 can be labeled with various radionuclides, such as 68Ga, 18F, 55Co, and 111In. In a mouse prostate cancer xenograft model, BQ7859 (labeled with 111In) efficiently accumulates in tumor regions in a PSMA-dependent manner and provides high-contrast tumor imaging. BQ7859 shows potential for research in prostate cancer imaging, particularly in positron emission tomography (PET) and single-photon emission computed tomography (SPECT) . BQ7859 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99239
-
|
HUJ-591
|
PSMA
Radionuclide-Drug Conjugates (RDCs)
|
Cancer
|
|
Rosopatamab (HuJ591) is a humanized antiPSMA IgG1 monoclonal antibody that can be used in cancer research, especially prostate cancer. Rosopatamab can be linked to the low-energy beta-emitting radioisotope lutetium-177 ( 177Lu) through the bifunctional chelator DOTA-NHS ester to obtain a radioimmunoconjugate that targets malignant prostate cells with high efficiency .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-113354S
-
|
|
|
Anserine-d4 is the deuterium labeled Anserine. Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice[1][2].
|
-
-
- HY-Y0682S
-
|
|
|
EDTA-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
|
-
-
- HY-17359S
-
|
|
|
Deferasirox-d4 is the deuterium labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload[1][2][3].
|
-
-
- HY-113354S1
-
|
|
|
Anserine-d4 hydrochloride is the deuterium labeled Anserine (HY-113354). Anserine, a methylated form of Carnosine, is an orally active, natural Histidine-containing dipeptide found in skeletal muscle of vertebrates. Anserine is not cleaved by serum carnosinase and act as biochemical buffers, chelators, antioxidants, and anti-glycation agents. Anserine improves memory functions in Alzheimer's disease (AD)-model mice .
|
-
-
- HY-W004544S
-
|
|
|
o-Phenanthroline-d8 is the deuterium labeled o-Phenanthroline. o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) is also a MMP inhibitor[1][2].
|
-
-
- HY-Y0682S1
-
|
|
|
Ethylenediaminetetraacetic acid-d16 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].
|
-
-
- HY-W012788S
-
|
|
|
Maltol-d3 is a deuterium labeled Maltol (HY-W012788). Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-158067
-
|
DFO-DBCO
|
|
DBCO
|
|
Deferoxamine-DBCOis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DFO derivative used for tumor pre-targeting. Deferoxamine-DBCO can be used for conjugation of peptides and radionuclides.
|
-
- HY-W782078
-
|
|
|
Alkynes
|
|
Butyne-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Butyne-DOTA can be used for conjugation of peptides and radionuclides.
|
-
- HY-W539916
-
|
|
|
Azide
|
|
Azido-mono-amide-DOTAis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Azido-mono-amide-DOTA can be used for conjugation of peptides and radionuclides.
|
-
- HY-W749627
-
|
|
|
Alkynes
|
|
NO2A-Butyneis a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NO2A-Butyne can be used for conjugation of peptides and radionuclides.
|
-
- HY-131036
-
|
|
|
Alkynes
|
|
MAO-IN-M30 dihydrochloride is an orally active, brain-permeable, and brain selective irreversible MAO-A (IC50=37 nM) and MAO-B (IC50=57 nM) inhibitor. MAO-IN-M30 dihydrochloride is a potent iron chelator and radical scavenger. MAO-IN-M30 dihydrochloride has a neuroprotective effect against Dexamethasone-induced brain cell apoptosis. MAO-IN-M30 dihydrochloride also exhibits neurorestorative activity in post MPTP and lactacystin models of Parkinson's disease . MAO-IN-M30 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-W451440
-
|
|
|
Alkynes
|
|
Butyne-DOTA-tris(t-butyl ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic DOTA derivative used for tumor pre-targeting. Butyne-DOTA-tris(t-butyl ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W717800A
-
|
|
|
Azide
|
|
NO2A-Azide (trihydrochloride)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NO2A-Azide (trihydrochloride) can be used for conjugation of peptides and radionuclides.
|
-
- HY-W749614
-
|
|
|
Alkynes
|
|
NO2A-Butyne-bis(t-Butyl ester)is a bifunctional chelator (Bifunctional Chelator; BFC) and a macrocyclic NOTA derivative used for tumor pre-targeting. NO2A-Butyne-bis(t-Butyl ester) can be used for conjugation of peptides and radionuclides.
|
-
- HY-158065
-
|
|
|
Azide
|
|
Azido-mono-amide-DOTA-tris(t-Bu ester) is a biochemical assay reagent, and is a click chemistry reagent .
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W012788
-
Maltol
2 Publications Verification
|
|
Sweetening Agents
Flavoring Agents
|
|
Maltol, a type of aromatic compound, is an antioxidant agent. Maltol enhances neural function by mitigating oxidative stress and cell apoptosis. Maltol is an inhibitor of oxidative damage in nerve cells and is effective in preventing diabetic peripheral neuropathy (DPN). Maltol is used extensively as a safe flavoring agent and food preservative. Maltol is a metal ion chelator that can be used in the field of catalysis, cosmetics, and medicine .
|
-
- HY-D0850
-
|
Sodium tartrate dibasic dihydrate; Sodium tartrate dihydrate
|
|
Chelating Agents
|
|
Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications .
|
-
- HY-Y0682A
-
|
EDTA disodium dihydrate
|
|
Antioxidants
Chelating Agents
|
|
Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research .
|
Your information is safe with us. * Required Fields.
Inquiry Information
- Product Name:
- Cat. No.:
- Quantity:
- MCE Japan Authorized Agent:
![[S-Methanethiosulfonylcysteaminyl]ethylenediamine-N,N,N',N'-tetraacetic acid](http://file.medchemexpress.eu/product_pic/hy-w127798.gif)
