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Results for "

E 2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetyl-CoA Carboxylase (1) Amino Acid Derivatives (1) Androgen Receptor (1) Antibiotic (2) Apolipoprotein (1) Apoptosis (11) Autophagy (5) Bacterial (4) Bcl-2 Family (2) Biochemical Assay Reagents (10) Cannabinoid Receptor (2) Casein Kinase (1) CDK (10) Checkpoint Kinase (Chk) (1) COX (7) Cytochrome P450 (6) DNA/RNA Synthesis (1) Drug Derivative (3) Drug Isomer (1) Drug Metabolite (3) E1/E2/E3 Enzyme (7) Early 2 Factor (E2F) (3) EBV (1) Endogenous Metabolite (25) Epigenetic Reader Domain (2) Estrogen Receptor/ERR (14) Eukaryotic Initiation Factor (eIF) (1) Flavivirus (1) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (1) Fungal (1) HCV (3) HDAC (1) Histone Methyltransferase (3) HMG-CoA Reductase (HMGCR) (1) HPV (3) Interleukin Related (2) Isotope-Labeled Compounds (16) JNK (1) Keap1-Nrf2 (6) Lipoxygenase (4) MDM-2/p53 (2) Microtubule/Tubulin (5) Mixed Lineage Kinase (1) Molecular Glues (2) Monoamine Oxidase (2) nAChR (1) NF-κB (5) NO Synthase (4) Nuclear Hormone Receptor 4A/NR4A (1) Organoid (1) Parasite (2) PARP (2) PGE synthase (11) Phospholipase (2) PKC (1) Potassium Channel (1) PPAR (1) Prostaglandin Receptor (61) PROTACs (3) Reactive Oxygen Species (8) SARS-CoV (1) Small Interfering RNA (siRNA) (13) STAT (3) Steroid Sulfatase (1) Survivin (2) Syk (1) TNF Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (68) Cardiovascular Disease (18) Endocrinology (30) Infection (13) Inflammation/Immunology (45) Metabolic Disease (22) Neurological Disease (16)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (13) siRNAs (13)

211

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0141

Estradiol Maximum Cited Publications 87 Publications Verification β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Endocrinology Cancer
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-N3149

*(E)-2-Hydroxycinnamaldehyde*	STAT Apoptosis Reactive Oxygen Species	Cancer
(E)-2-Hydroxycinnamaldehyde is an aldehyde that can be separated from the stem bark of cinnamon. (E)-2-Hydroxycinnamaldehyde inhibits cell proliferation and induces apoptosis by inhibiting signal transduction of STAT3 and reactive oxygen species production. (E)-2-Hydroxycinnamaldehyde has antitumor activity .

HY-W010533

*(E)-2-Methyl-2-pentenoic acid*	Others	Others
(E)-2-Methyl-2-pentenoic acid is the component can be used to synthesize the cytotoxic natural product Lactimidomycin .

HY-13211

*(E)-2-Decenoic acid* trans-2-Decenoic acid	Endogenous Metabolite	Cancer
(E)-2-Decenoic acid is an interesting fatty acid isolated from royal jelly secretions of honey bees.

HY-133022

trans-2-Undecenoic acid (E)-2-Undecenoic acid; (E)-Undec-2-enoic acid	Drug Isomer	Metabolic Disease
trans-2-Undecenoic acid ((E)-2-Undecenoic acid) is an α,β-unsaturated carboxylic acid and is characterized by acid dimers. The corresponding dimers are connected via intermolecular hydrogen bonds of the carboxylic groups C=O···H-O .

HY-106828

E2-CDS Estradiol 17-Dihydrotrigonelline	Estrogen Receptor/ERR	Metabolic Disease
E2-CDS (Estradiol 17-Dihydrotrigonelline) is a redox-based chemical delivery system for estradiol (E2). E2-CDS is capable of sustained and brain-selective delivery of estradiol .

HY-N7557

*(E)-2'-Hydroxy-3,4-dimethoxychalcone*	Drug Derivative	Cancer
(E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) is a Chalcone derivative with orally active. (E)-2'-Hydroxy-3,4-dimethoxychalcone has anti-tumour activities .

HY-W082859A

*(E)-2′,4′-Dimethoxychalcone*	Others	Others
(E)-2′,4′-Dimethoxychalcone is a flavonoid compound .

HY-121683

*(E)-2-Hexadecenal* trans-2-Hexadecenal	Mixed Lineage Kinase Apoptosis JNK Microtubule/Tubulin	Cancer
(E)-2-Hexadecenal (trans-2-Hexadecenal) is an MLK3 activator that induces cytoskeletal remodeling, leading to cell rounding, detachment, and ultimately apoptosis in human and mouse cells. (E)-2-Hexadecenal activates the MLK3 signaling pathway, phosphorylating MKK4/7 and JNK, subsequently activating downstream targets of JNK, such as c-Jun phosphorylation, cytochrome c release, Bax activation, Bid cleavage, and Bim translocation to mitochondria. (E)-2-Hexadecenal has potential applications in research related to sphingolipid signaling pathways .

HY-117072

*(E)-2-Hexadecenal alkyne*	Fluorescent Dye	Others
(E)-2-Hexadecenal alkyne (compound 2) is a chemical probe used to explore the cellular targets of 2-trans-Hexadecenal. It can covalently modify multiple proteins in cells and provide a tool for studying lipid metabolism-related diseases.

HY-133655

*(E)-2,3-Dibromo-2-butenedioic acid*	Drug Derivative	Others
(E)-2,3-Dibromo-2-butenedioic acid is one of brominated haloacids, which are the drinking water disinfection byproducts (DBPs) .

HY-165761

D-Threo-sphingosine (E)-2-Aminooctadec-4-ene-1,3-diol	Biochemical Assay Reagents	Metabolic Disease
D-Threo-sphingosine ((E)-2-Aminooctadec-4-ene-1,3-diol) is an ester product.

HY-W013652

*(E)-2-(2-Methylbut-2-enamido)acetic acid* Tiglylglycine	Amino Acid Derivatives	Others
(E)-2-(2-Methylbut-2-enamido)acetic acid is a Glycine (HY-Y0966) derivative .

HY-RS04115

E2F6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
E2F6 Human Pre-designed siRNA Set A contains three designed siRNAs for E2F6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

E2F6 Human Pre-designed siRNA Set A E2F6 Human Pre-designed siRNA Set A

HY-RS04113

E2F4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
E2F4 Human Pre-designed siRNA Set A contains three designed siRNAs for E2F4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

E2F4 Human Pre-designed siRNA Set A E2F4 Human Pre-designed siRNA Set A

HY-RS04111

E2F2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
E2F2 Human Pre-designed siRNA Set A contains three designed siRNAs for E2F2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

E2F2 Human Pre-designed siRNA Set A E2F2 Human Pre-designed siRNA Set A

HY-RS04112

E2F3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
E2F3 Human Pre-designed siRNA Set A contains three designed siRNAs for E2F3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

E2F3 Human Pre-designed siRNA Set A E2F3 Human Pre-designed siRNA Set A

HY-RS04110

E2F1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
E2F1 Human Pre-designed siRNA Set A contains three designed siRNAs for E2F1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

E2F1 Human Pre-designed siRNA Set A E2F1 Human Pre-designed siRNA Set A

HY-RS04117

E2F8 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
E2F8 Human Pre-designed siRNA Set A contains three designed siRNAs for E2F8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

E2F8 Human Pre-designed siRNA Set A E2F8 Human Pre-designed siRNA Set A

HY-RS04114

E2F5 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
E2F5 Human Pre-designed siRNA Set A contains three designed siRNAs for E2F5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

E2F5 Human Pre-designed siRNA Set A E2F5 Human Pre-designed siRNA Set A

HY-RS04116

E2F7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
E2F7 Human Pre-designed siRNA Set A contains three designed siRNAs for E2F7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

E2F7 Human Pre-designed siRNA Set A E2F7 Human Pre-designed siRNA Set A

HY-173163

*(E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium trifluoromethanesulfonate*	Bacterial	Infection
(E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium (trifluoromethanesulfonate) (Compound 4a) is a Gram-negative outer membrane permeabilizer with synergistic antibacterial activity through the blockage on LptA/LptC interaction via targeting Met47 in LptA. (E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium (trifluoromethanesulfonate) potentiates pol B against both wild-typed and MDR A. baumannii and E. coli strains. (E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium (trifluoromethanesulfonate) can be used as antibiotic adjuvants against MDR Gram-negative bacteria .

HY-W710681S

*(E)-2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylic acid-d4*	Isotope-Labeled Compounds	Others
(E)-2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylic acid-d₄ is deuterium labeled (E)-2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylic acid .

HY-19340

TMS 5+ Cited Publications (E)-2,3',4,5'-tetramethoxystilbene	Cytochrome P450	Cancer
TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC₅₀ of 6 nM and a K_i value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC₅₀=300 nM) and CYP1A2 (IC₅₀=3.1 μM). TMS is a methylated derivative of resveratrol and has anti-cancer activity .

HY-U00112

Estradiol 3-sulfamate BLE 00084; E2MATE; ES-J 995	Steroid Sulfatase	Cancer
Estradiol 3-sulfamate (BLE 00084; E2MATE; ES-J 995) is a potent, long-acting, and orally active steroid sulfatase inhibitor; inhibits estrone sulfatase with an IC₅₀ of 251 nM and a K_i of 133 nM.

HY-13211R

*(E)-2-Decenoic acid (Standard)*	Endogenous Metabolite	Cancer

HY-Y1644

NSC 8751 (E)-2-Butenoic acid; (E)-Crotonic acid; trans-2-Butenoic acid; trans-Crotonic acid	Endogenous Metabolite	Metabolic Disease
NSC 8751 is an endogenous metabolite.

HY-B0141R

Estradiol (Standard) Maximum Cited Publications 87 Publications Verification β-Estradiol(Standard); E2(Standard); 17β-Estradiol(Standard); 17β-Oestradiol (Standard)	Estrogen Receptor/ERR Endogenous Metabolite Bacterial	Endocrinology Cancer
Estradiol (Standard) is the analytical standard of Estradiol. This product is intended for research and analytical applications. Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-B0141S6

Estradiol-d2-1 β-Estradiol-d₂-1; E2-d₂-1; 17β-Estradiol-d₂-1; 17β-Oestradiol-d₂-1	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Neurological Disease Inflammation/Immunology
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3][4].

HY-B0141S4

Estradiol-13C6 β-Estradiol-¹³C₆; E2-¹³C₆; 17β-Estradiol-¹³C₆; 17β-Oestradiol-¹³C₆	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol- ¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-B0141S5

Estradiol-13C2 β-Estradiol-¹³C₂; E2-¹³C₂; 17β-Estradiol-¹³C₂; 17β-Oestradiol-¹³C₂	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estradiol- ¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-133159

Resolvin E2 (-)-Resolvin E2	Lipoxygenase	Inflammation/Immunology
Resolvin E2 ((-)-Resolvin E2), a proresolving lipid mediator, is useful as a lead for anti-inflammatory agent .

HY-N12153

Theasaponin E2	Others	Cancer
Theasaponin E2 shows cytotoxicity against K562 and HL60 cells (IC₅₀: 14.7 μg/mL). Theasaponin E2 can be isolated from Camellia sinensis .

HY-N8098

Pulchinenoside E2	Others	Cancer
Pulchinenoside E2 (Compound 8) is a triterpene saponin isolated from the roots of Pulsatilla chinensis. Pulchinenoside E2 shows cytotoxic to HL-60 cells with an IC₅₀ value of 2.6 µg/mL .

HY-114910

11-Deoxy Prostaglandin E2	Prostaglandin Receptor	Cancer
11-Deoxy Prostaglandin E2 is a selective agonist of EP4 with an EC₅₀ of 0.66 nM. 11-Deoxy Prostaglandin E2 is an analog of prostaglandin E2. 11-Deoxy Prostaglandin E2 can be used in study bone healing, heart failure, and other receptor associated conditions .

HY-N12649

Timosaponin E2	Reactive Oxygen Species	Inflammation/Immunology
Timosaponin E2 is an antiinflammatory agent, and inhibits active oxygen production .

HY-169028

8-Iso prostaglandin E2 isopropyl ester	Prostaglandin Receptor	Cardiovascular Disease
8-Iso prostaglandin E2 isopropyl ester is a more lipophilic form of the free acid, 8-iso Prostaglandin E2.

HY-N7231

Licoricesaponin E2	Others	Others
Licoricesaponin E2 (compound 5) is a triterpene saponinthat can be found in Glycyrrhiza inflata .

HY-P4027

HCV-1 e2 Protein (554-569)	HCV	Infection
HCV-1 e2 Protein (554-569) is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) contains a putative n-glycosylation site, which was previously thought to influence the immune recognition of e2 .

HY-130694

15(R)-Prostaglandin E2 15-epi-Prostaglandin E2	Prostaglandin Receptor	Others
15(R)-Prostaglandin E2 is a prostaglandin derivative that can be isolated from the Plexaura homomalla .

HY-107027

Polymyxin E2 sulfate	Antibiotic	Infection
Polymyxin E2 sulfate is an antibiotic produced by the soil bacterium Bacillus polymyxa .

HY-P4027A

HCV-1 e2 Protein (554-569) (TFA)	HCV	Infection
HCV-1 e2 Protein (554-569) TFA is one of the main antigenic regions of HCV envelope 2 (e2) protein. The HCV-1 e2 Protein (554-569) TFA contains a putative N-glycosylation site, which was previously thought to influence the immune recognition of e2 .

HY-N9829

Methyl lucidenate E2	Others	Others
Methyl lucidenate E2 is a Triterpenoids product that can be isolated from the fruit body of Ganoderma lucidum .

HY-118681

8-Iso-16-cyclohexyl-tetranor prostaglandin E2	Prostaglandin Receptor	Others
8-Iso-16-cyclohexyl-tetranor prostaglandin E2 is an analog of Prostaglandin E2 (HY-101952) .

HY-N13710

20-Hydroxylucidenic acid E2	EBV	Infection Cancer
20-Hydroxylucidenic acid E2 is a triterpenoid compound found in Ganoderma lucidum. It exhibits significant inhibitory effects on inflammation induced by TPA (HY-18739). Additionally, 20-Hydroxylucidenic acid E2 can suppress the expression of EBV early antigen induced by TPA (HY-18739), with a IC₅₀ of 290 mol ratio/32 pmol TPA (meaning that when the molar concentration of this compound is 290 times that of 32 pmol of TPA, it can inhibit 50% of EBV early antigen expression). Therefore, 20-Hydroxylucidenic acid E2 has potential applications in anti-inflammatory and anticancer research .

HY-118556

Prostaglandin E2 serinol amide	Prostaglandin Receptor	Endocrinology
Prostaglandin E2 serinol amide is a weak inhibitor of the hydrolysis of [3H]2-oleoylglycerol. Prostaglandin E2 serinol amide is non-hydrolyzable to produce PGE2 and thus cannot inhibit leukotriene B4 biosynthesis, superoxide production, migration and antimicrobial peptide release .

HY-113205

15-keto-Prostaglandin E2 15-keto-PGE2	Endogenous Metabolite Prostaglandin Receptor STAT PPAR	Cancer
15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth .

HY-129920

Prostaglandin E2 methyl ester PGE2 methyl ester	Drug Derivative	Metabolic Disease
Prostaglandin E2 methyl ester (PGE2 methyl ester) is an lipophilic derivative analog of PGE2 (HY-101952). Prostaglandin E2 methyl ester has more central penetration ability than PGE2 .

HY-130304

8-Isoprostaglandin E2 iPE2-III	Prostaglandin Receptor	Cardiovascular Disease
8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A₂ (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway .

HY-101952G

Prostaglandin E2 PGE2; Dinoprostone	Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2 (GMP) is Prostaglandin E2 (HY-101952) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Prostaglandin E2, an inflammatory mediator, is a endogenous hormone-like substance that participate in a wide range of body functions .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0141

Estradiol Maximum Cited Publications 87 Publications Verification β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol	Structural Classification Classification of Application Fields Source classification Endocrine diseases Endogenous metabolite Monophenols Sunscreen Disease markers Phenols Cosmetic Research Disease Research Fields Steroids Cancer	Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-N3149

*(E)-2-Hydroxycinnamaldehyde*	Structural Classification Monophenols Cinnamomum cassia (L.) D. Don Source classification Phenols Plants Lauraceae	STAT Apoptosis Reactive Oxygen Species
(E)-2-Hydroxycinnamaldehyde is an aldehyde that can be separated from the stem bark of cinnamon. (E)-2-Hydroxycinnamaldehyde inhibits cell proliferation and induces apoptosis by inhibiting signal transduction of STAT3 and reactive oxygen species production. (E)-2-Hydroxycinnamaldehyde has antitumor activity .

HY-Y1644

NSC 8751 (E)-2-Butenoic acid; (E)-Crotonic acid; trans-2-Butenoic acid; trans-Crotonic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NSC 8751 is an endogenous metabolite.

HY-B0141R

Estradiol (Standard) Maximum Cited Publications 87 Publications Verification β-Estradiol(Standard); E2(Standard); 17β-Estradiol(Standard); 17β-Oestradiol (Standard)	Structural Classification Classification of Application Fields Sunscreen Source classification Disease markers Phenols Endocrine diseases Cosmetic Research Endogenous metabolite Disease Research Fields Steroids Cancer	Estrogen Receptor/ERR Endogenous Metabolite Bacterial
Estradiol (Standard) is the analytical standard of Estradiol. This product is intended for research and analytical applications. Estradiol (β-Estradiol) is a steroid hormone and the major female sex hormone. Estradiol can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. Estradiol can be used for the research of cancers, neurodegenerative diseases and neural tissue engineering .

HY-N12153

Theasaponin E2	Structural Classification Polysaccharides Source classification Plants Camellia sinensis (L.) O. Ktze. Saccharides Theaceae	Others
Theasaponin E2 shows cytotoxicity against K562 and HL60 cells (IC₅₀: 14.7 μg/mL). Theasaponin E2 can be isolated from Camellia sinensis .

HY-N8098

Pulchinenoside E2	Triterpenes Structural Classification Classification of Application Fields Terpenoids Ranunculaceae Source classification Plants Disease Research Fields Pulsatilla chinensis (Bunge) Regel Cancer	Others
Pulchinenoside E2 (Compound 8) is a triterpene saponin isolated from the roots of Pulsatilla chinensis. Pulchinenoside E2 shows cytotoxic to HL-60 cells with an IC₅₀ value of 2.6 µg/mL .

HY-N12649

Timosaponin E2	Structural Classification Polysaccharides Liliaceae Source classification Anemarrhena asphodeloides Bunge Plants Saccharides	Reactive Oxygen Species
Timosaponin E2 is an antiinflammatory agent, and inhibits active oxygen production .

HY-N7231

Licoricesaponin E2	Triterpenes Structural Classification Leguminosae Glycyrrhiza inflata Batal. Terpenoids Source classification Plants	Others
Licoricesaponin E2 (compound 5) is a triterpene saponinthat can be found in Glycyrrhiza inflata .

HY-N9829

Methyl lucidenate E2	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
Methyl lucidenate E2 is a Triterpenoids product that can be isolated from the fruit body of Ganoderma lucidum .

HY-N13710

20-Hydroxylucidenic acid E2	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	EBV
20-Hydroxylucidenic acid E2 is a triterpenoid compound found in Ganoderma lucidum. It exhibits significant inhibitory effects on inflammation induced by TPA (HY-18739). Additionally, 20-Hydroxylucidenic acid E2 can suppress the expression of EBV early antigen induced by TPA (HY-18739), with a IC₅₀ of 290 mol ratio/32 pmol TPA (meaning that when the molar concentration of this compound is 290 times that of 32 pmol of TPA, it can inhibit 50% of EBV early antigen expression). Therefore, 20-Hydroxylucidenic acid E2 has potential applications in anti-inflammatory and anticancer research .

HY-113205

15-keto-Prostaglandin E2 15-keto-PGE2	Structural Classification Ketones, Aldehydes, Acids Marine algae Marine natural products Source classification	Endogenous Metabolite Prostaglandin Receptor STAT PPAR
15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth .

HY-101952R

Prostaglandin E2 (Standard) 35+ Cited Publications PGE2(Standard); Dinoprostone (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Endocrinology	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E2 (Standard) is the analytical standard of Prostaglandin E2. This product is intended for research and analytical applications. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

HY-101952

Prostaglandin E2 35+ Cited Publications PGE2; Dinoprostone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Endocrinology	Organoid Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

HY-N11566

(+)-Oxypeucedanin methanolate	Structural Classification Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt.	Prostaglandin Receptor
(+)-Oxypeucedanin methanolate (compound 9) is a natural compound with inhibitory effect on prostaglandin E2 production .

HY-138063

Siegeskaurolic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Compositae Tephrosia candida DC.	TNF Receptor NF-κB
Siegeskaurolic acid is an orally active anti-inflammatory agent. Siegeskaurolic acid inhibits the productions of nitric oxide (NO), prostaglandin E(2) (PGE(2)), tumor necrosis factor-alpha (TNF-alpha) and the activationon of nuclear factor-kappaB .

HY-N10431

Stigmane B	Zea mays L. Terpenoids Gramineae Source classification Diterpenoids Plants	Keap1-Nrf2
Stigmane B (Compound 2) is a nuclear factor E2-related factor (Nrf2) activator. Stigmane B downregulates apoptosis and reactive oxygen species (ROS) generation, and increases antioxidant enzyme activities. Stigmane B shows neuroprotective effects .

HY-N2391

p-Hydroxycinnamic acid	Structural Classification Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite Disease Research Fields Endocrinology	Endogenous Metabolite Prostaglandin Receptor
p-Hydroxycinnamic acid, a common dietary phenol, could inhibit platelet activity, with IC₅₀s of 371 μM, 126 μM for thromboxane B₂ production and lipopolysaccharide-induced prostaglandin E₂ generation, respectively.

HY-N3380

Linderaspirone A	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	PGE synthase Interleukin Related
Linderaspirone A is a natural compound that can be isolated from the roots of Lindera aggregate. Linderaspirone A shows significant inhibitory effects on the production of prostaglandin E2 (PGE2),TNF-α, and IL-6 .

HY-N10226

Thielavin B	Cardiovascular Disease Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields	Prostaglandin Receptor
Thielavin B is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin B effectively influences the prostaglandin E2 synthesis from the endoperoxide. Thielavin B is significantly effective on carrageenan-induced oedema of rats when administered intravenously .

HY-N8127

*(1(10)E,2R,4R)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one*	other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Other Diseases Plants Disease Research Fields	Others
(1(10)E,2R,4R)-2-Methoxy-8,12-epoxygermacra-1(10),7,11-trien-6-one (compound 6) is a sesquiterpene .

HY-N0223

Epibetulinic acid	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Endocrinology	NO Synthase Prostaglandin Receptor
Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC₅₀s of 0.7 and 0.6 μM, respectively. Anti-inflammatory activity .

HY-114988

PGE-M tetranor-PGEM	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Endogenous Metabolite
PGE-M is a metabolite of prostaglandin E₂ (PEG₂) as a biomarker of inflammation and cancer including advanced colorectal neoplasia, ovarian cancer, prostate cancer and so on. Urinary PGE-M is positively associated with obesity, smoking and lung metastases with breast cancer .

HY-N6966

Ethyl Caffeate 1 Publications Verification	Structural Classification Classification of Application Fields Phenols Polyphenols Amburana cearensis (Allemão) A.C.Sm. Plants Compositae Inflammation/Immunology Disease Research Fields Cancer	NF-κB NO Synthase COX PGE synthase
Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin .

HY-N2106

Dehydroevodiamine 1 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids	NF-κB COX PGE synthase NO Synthase
Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated from Evodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes . Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells .

HY-N3535

Canniprene	Structural Classification Monophenols Cannabis sativa L Classification of Application Fields Source classification Phenols Plants Moraceae Inflammation/Immunology Disease Research Fields	Prostaglandin Receptor Lipoxygenase
Canniprene, an isoprenylated bibenzyl unique to Cannabis sativa, is a potent inhibitor of 5-lipoxygenase (5-LO) activity (IC₅₀=0.4 μM) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE₂; IC₅₀=10 μM). Canniprene inhibits the production of inflammatory eicosanoids and affects the generation of prostaglandins .

HY-N8160

Dehydrocurdione	Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Curcuma phaeocaulis Valeton Disease Research Fields Inflammation/Immunology Zingiberaceae	Keap1-Nrf2 Reactive Oxygen Species
Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity .

HY-N4237

Saikogenin D	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Umbelliferae Plants Inflammation/Immunology Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray	Prostaglandin Receptor Potassium Channel
Saikogenin D is isolated from?Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca ²⁺]i due to Ca ²⁺ release from intracellular stores .

HY-N0074

Byakangelicol 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt. Inflammation/Immunology Disease Research Fields	COX
Byakangelicol, isolated from Angelica dahurica, inhibits interleukin-1beta (IL-1beta) -induced prostaglandin E2 (PGE2) release in A549 cells mediated by suppression of cyclooxygenase-2 (COX-2) expression and the activity of COX-2 enzyme. Byakangelicol has therapeutic potential as an anti-inflammatory agent on airway inflammation .

HY-N6966A

Ethyl trans-caffeate	Source classification Lactuca perennis Plants Compositae	Others
Ethyl trans-caffeate is the trans form of Ethyl Caffeate (HY-N6966). Ethyl Caffeate is a natural phenolic compound isolated from Bidens pilosa. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and prostaglandin E₂ (PGE₂) in vitro or in mouse skin .

HY-N6802

Tigloylgomisin H	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Disease Research Fields Cancer	Keap1-Nrf2
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent .

HY-12033

2-Methoxyestradiol 25+ Cited Publications 2-ME2; NSC-659853	Structural Classification Monophenols Classification of Application Fields Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer	Microtubule/Tubulin Reactive Oxygen Species Apoptosis Autophagy Endogenous Metabolite
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa .

HY-N8936

Narchinol B	Structural Classification Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Others
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α). Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC₅₀=2.43 μM) .

HY-155156

PF-07238025	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
PF-07238025 is a BCKDC kinase (BDK) inhibitor (EC₅₀=19 nM). PF-07238025 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07238025 improved cardiometabolic endpoints and improves glucose tolerance in mice .

HY-155157

PF-07247685	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Endogenous Metabolite
PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC₅₀=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice .

Cat. No.	Product Name	Chemical Structure

HY-B0141S6

Estradiol-d2-1
Estradiol-d₂-1 is the deuterium labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3][4].

HY-B0141S5

Estradiol-13C2
Estradiol- ¹³C₂ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-101952S

Prostaglandin E2-d4
Prostaglandin E2-d₄ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-W710681S

*(E)-2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylic acid-d4*
(E)-2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylic acid-d₄ is deuterium labeled (E)-2-(2-((6-(2-Cyanophenoxy)pyrimidin-4-yl)oxy)phenyl)-3-methoxyacrylic acid .

HY-B0141S4

Estradiol-13C6
Estradiol- ¹³C₆ is the ¹³C-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway[1][2][3].

HY-121996S

Prostaglandin E2 ethanolamide-d4
Prostaglandin E2 Ethanolamide-d4 (PGE2 ethanolamide-d4) is the deuterium labeled Prostaglandin E2 Ethanolamide (HY-121996) .

HY-113205S1

15-Keto-prostaglandin E2-d4
15-Keto-prostaglandin E2-d₄ is the deuterium labeled 15-Keto-prostaglandin E2[1].

HY-113205S

15-Keto-prostaglandin E2-d9
15-Keto-prostaglandin E2-d₉ is the deuterium labeled 15-Keto-prostaglandin E2[1].

HY-130304S

8-Isoprostaglandin E2-d4

8-Isoprostaglandin E2-d₄ (iPE2-III-d₄) is deuterium labeled 8-Isoprostaglandin E2. 8-Isoprostaglandin E2 (iPE2-III) is a member of the isoprostane class of prostanoids. 8-Isoprostaglandin E2 acts at the receptor for thromboxane A₂ (the TP) in vivo to induce vasoconstriction and platelet aggregation. 8-Isoprostaglandin E2 enhances receptor-activated NFkappa B ligand (RANKL)-dependent osteoclastic potential of marrow hematopoietic precursors via the cAMP pathway .

HY-101952S1

Prostaglandin E2-d9
Prostaglandin E2-d₉ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-114826S

Prostaglandin E2-1-glyceryl ester-d5
Prostaglandin E2-1-glyceryl ester-d₅ (PGE2-1-glyceyl ester-d₅) is deuterium labeled Prostaglandin E2-1-glyceryl ester. Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB₁ receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca ²⁺ .

HY-W779542

(2E,4E,6E)-2,4,6-Nonatrienal-13C2
(2E,4E,6E)-2,4,6-Nonatrienal- ¹³C₂ is ¹³C labeled (2E,4E,6E)-2,4,6-Nonatrienal.

HY-13286S

*N-Hydroxy (E)-2-(4-methoxybenzoxy)-4-methoxy-3-prenylcinnamamide-d6*
N-Hydroxy (E)-2-(4-methoxybenzoxy)-4-methoxy-3-prenylcinnamamide-d₆ is the deuterium labeled N-Hydroxy (E)-2-(4-methoxybenzoxy)-4-methoxy-3-prenylcinnamamide[1].

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6][7].

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa[1][2][3][4][5][6].

HY-165668S

Pitavastatin lactone-d4
Pitavastatin lactone-d₄ (6S-((E)-2-(2-Cyclopropyl-4-(4-fluorophenyl-2,3,5,6-d₄)quinolin-3-yl)vinyl)-4R-hydroxytetrahydro-2H-pyran-2-one) is deuterium labeled Pitavastatin lactone .

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Species:	Virus (20) Human (61) Rat (1) Mouse (6) Xenopus laevis (1)
Tag:	GFP (1) His (58) Tag Free (17) Strep (16) Myc (3) GST (10) Flag (2) Fc (5)
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