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RP

" in MedChemExpress (MCE) Product Catalog:

135

Inhibitors & Agonists

1

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1

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3

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6

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74

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12

Isotope-Labeled Compounds

23

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4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-151462
    RP-6685
    1 Publications Verification

    DNA/RNA Synthesis Cancer
    RP-6685 is a potent, selective and orally active DNA polymerase theta (Polθ) inhibitor with an IC50 value of 5.8 nM (PicoGreen assay). RP-6685 shows antitumor efficacy in mouse tumor xenograft model . RP-6685 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    RP-6685
  • HY-101939A

    LPL Receptor Neurological Disease
    RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5 .
    RP-001 hydrochloride
  • HY-B0512
    Sulfamerazine
    1 Publications Verification

    RP2632

    Bacterial Antibiotic Infection
    Sulfamerazine (RP-2632) is a sulfonamide antibacterial.
    Sulfamerazine
  • HY-P5568

    HIV Infection
    RP 71955 is an antimicrobial peptide against HIV-1 .
    RP 71955
  • HY-100288

    Acyltransferase Metabolic Disease
    RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity.
    RP 73163 Racemate
  • HY-135110

    RP-8-bromo-Cyclic GMPS sodium

    Calcium Channel PKG HCN Channel Metabolic Disease
    Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca 2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca 2+ reduction by activating Ca 2+-ATPase and subsequently removing Ca 2+ from the cell .
    Rp-8-Br-cGMPS sodium
  • HY-135110A

    RP-8-bromo-Cyclic GMPS

    Calcium Channel PKG HCN Channel Metabolic Disease
    Rp-8-Br-cGMPS (Rp-8-bromo-Cyclic GMPS) sodium salt is a potent Ca 2+-ATPase activator. Rp-8-Br-cGMPS is also an agonist of the rod CNG channel and an inhibitor of PKG. Rp-8-Br-cGMPS sodium salt mediates cytosolic Ca 2+ reduction by activating Ca 2+-ATPase and subsequently removing Ca 2+ from the cell .
    Rp-8-Br-cGMPS
  • HY-110221

    PKG Neurological Disease
    Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner .
    Rp-8-pCPT-cGMPS sodium
  • HY-101939

    LPL Receptor Neurological Disease
    RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5 .
    RP-001
  • HY-114966

    Cholecystokinin Receptor Inflammation/Immunology
    RP73870 is an orally active gastrin/cholecystokinin-B receptor antagonist. RP73870 inhibits basal gastric acid secretion in the rat. RP73870 has potent anti-ulcer activity .
    RP73870
  • HY-137640B

    PKA Inflammation/Immunology Cancer
    Rp-8-Br-cAMPS is an analog of cAMP and an inhibitor of PKA. Rp-8-Br-cAMPS occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS also inhibits insulin secretion .
    Rp-8-Br-cAMPS
  • HY-137640C

    PKA Inflammation/Immunology Cancer
    Rp-8-Br-cAMPS sodium is an analog of cAMP and an inhibitor of PKA. Rp-8-Br-cAMPS sodium occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS sodium can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS sodium also inhibits insulin secretion .
    Rp-8-Br-cAMPS sodium
  • HY-101716

    Interleukin Related Inflammation/Immunology
    RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.
    RP-54745
  • HY-16437

    Acyltransferase Cardiovascular Disease
    RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).
    RP-64477
  • HY-122319

    RP-020630

    Herbicide Others
    Oxadiargyl (RP-020630) is an herbicide that inhibits protoporphyrinogen oxidase and has both pre- and early post-emergent weed activity. Oxadiargyl (RP-020630) has a short residual activity period, broad weed spectrum, and can be used in various soil types .
    Oxadiargyl
  • HY-P5565

    Bacterial Infection Cancer
    RP-1 is an antimicrobial peptide, and is active against S. aureus, S. typhimurium, E. coli, and C. albicans .
    RP-1
  • HY-108548

    RP-8-Bromo-PET-cGMPS

    Others Inflammation/Immunology
    Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.
    Rp-8-Br-PET-cGMPS sodium
  • HY-123270

    CCR Infection Inflammation/Immunology
    RP23618 is a non peptidic RANTES antagonist with the IC50 of 3 μM. RP23618 inhibit RANTES-induced chemotaxis of THP-1 cells .
    RP23618
  • HY-137373

    PKG Others
    Rp-8-pCPT-cGMPS is a competitive inhibitor of cGMP-dependent protein kinase (PKG) (Ki=0.5 μM). Rp-8-pCPT-cGMPS has high lipid solubility and can more easily penetrate the cell membrane and reach sufficient concentration inside the cell to inhibit cGMP-dependent protein kinase. Rp-8-pCPT-cGMPS can be used to study the activity and function of cGMP-dependent protein kinase in platelets .
    Rp-8-pCPT-cGMPS
  • HY-101576

    Acyltransferase Metabolic Disease
    RP 70676 is a potent inhibitor of ACAT, with IC50 of 25 and 44 nM for rat and rabbit ACAT.
    RP 70676
  • HY-120994

    PKA Neurological Disease Inflammation/Immunology
    Rp-8-CPT-cAMPS sodium, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS sodium preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI .
    Rp-8-CPT-cAMPS sodium
  • HY-120994A

    PKA Neurological Disease Inflammation/Immunology
    Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI .
    Rp-8-CPT-cAMPS
  • HY-108483

    Neurokinin Receptor Neurological Disease Inflammation/Immunology
    RP 67580 is a non-peptide antagonist of substance P (SP), competitively inhibits the binding of [3H]SP to neurokinin receptor 1 (NK1 receptor) in rat brain membranes with a Ki value of 4.16 nM. RP 67580 is a specific antagonist of NK1 receptors and can be used in the research of pain and neurogenic inflammation .
    RP 67580
  • HY-135359

    Drug Metabolite Neurological Disease
    RP 48497, an impurity of Eszopiclone, is a photodegradation product of Eszopiclone. Eszopiclone is a non-benzodiazepine agent used in the treatment of insomnia .
    RP 48497
  • HY-100481

    RPR101048

    Cholecystokinin Receptor Neurological Disease
    RP 72540 is a selective CCK-B receptor antagonist, with IC50 values of 2.4, 1.2, and 3.8 nM for CCK-B receptors in the guinea pig cerebral cortex, rat cerebral cortex, and mouse brain, respectively. RP 72540 effectively inhibits CCK-8-induced neuronal firing and dose-dependently inhibits gastric acid secretion, making it potentially valuable in studies of acid secretion. RP 72540 is an important tool for investigating the physiological functions of CCK B receptors .
    RP 72540
  • HY-136576

    LPL Receptor Drug Metabolite Inflammation/Immunology
    RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile .
    RP101075
  • HY-126715

    RP 44102

    Others Inflammation/Immunology
    Pimelautide (RP 44102), a desmuramyl peptidolipid, is an adjuvant. Pimelautide shows a LD50 of 410 mg/kg (i.v, mouse) .
    Pimelautide
  • HY-100530A

    PKA Neurological Disease
    Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases .
    Rp-cAMPS
  • HY-100530D
    Rp-cAMPS sodium salt
    3 Publications Verification

    PKA Neurological Disease
    Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases .
    Rp-cAMPS sodium salt
  • HY-145817A
    lunresertib
    1 Publications Verification

    RP-6306

    Wee1 Cancer
    lunresertib (RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC50 of 14 nM. lunresertib shows a high degree of selectivity over other kinases in cellular binding assays. lunresertib shows anticancer effects .
    lunresertib
  • HY-101665

    (+)-RP-59037; IP-456; RP-62955

    GABA Receptor Neurological Disease
    Pagoclone is an active (+)-enantiomer of the racemate RP 59037. Pagoclone is a partial GABA(A) receptor agonist used for the treatment of panic and anxiety disorders.
    Pagoclone
  • HY-B0227
    Ketoprofen
    4 Publications Verification

    RP-19583

    COX Metabolic Disease Inflammation/Immunology Cancer
    Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .
    Ketoprofen
  • HY-169089

    Others Cancer
    RP-182-PEG3-K palmitic acid (Compound 1a) inhibits CD206 high M2-like macrophage (IC50 of 3.2 µM) and induces phagocytosis. RP-182-PEG3-K palmitic acid exhibits antitumor efficacy in mouse B16 melanoma allografts .
    RP-182-PEG3-K(palmitic acid)
  • HY-101585

    RP 58802B

    Adrenergic Receptor Neurological Disease Endocrinology
    Imoxiterol (RP 58802B) is a β-adrenergic agonist.
    Imoxiterol
  • HY-100530

    PKA Neurological Disease
    Rp-cAMPS triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS triethylammonium salt is resistant to hydrolysis by phosphodiesterases .
    Rp-cAMPS triethylammonium salt
  • HY-137618B

    HIV Others
    Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates .
    Rp-dGTPαS
  • HY-B0011
    Docetaxel
    Maximum Cited Publications
    101 Publications Verification

    RP-56976

    Microtubule/Tubulin Apoptosis Endogenous Metabolite Cancer
    Docetaxel (RP-56976) is a microtubule depolymerization inhibitor, with an IC50 of 0.2 μM. Docetaxel attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .
    Docetaxel
  • HY-100664

    RP 29753

    Drug Metabolite GABA Receptor Neurological Disease
    Zopiclone N-oxide (RP 29753) is a less active metabolite of Zopiclone. Zopiclone N-oxide is also an impurity of Eszopiclone and is formed by the oxidation of Eszopiclone .
    Zopiclone N-oxide
  • HY-116139

    Merlin; RP-201772

    Herbicide Infection
    Isoxaflutole (Merlin; RP-201772) is a selective herbicide for pre-emergence control of a wide range of important broadleaf and grass weeds in corn and sugarcane. Isoxaflutole is a precursor and delivery vector of diketonitrile (DKN), which is an inhibitor for 4-hydroxyphenylpyruvate dioxygenase (HPPD), leads to a characteristic bleaching of susceptible species .
    Isoxaflutole
  • HY-106038

    Dacopafant; RP 55778

    HIV Platelet-activating Factor Receptor (PAFR) Infection
    Acopafant (Dacopafant; RP 55778) is a potent platelet-activating factor antagonist. Acopafant inhibits the induction of human immunodeficiency virus (HIV) expression in chronically infected cells. Acopafant has the potential for the research of HIV infection .
    Acopafant
  • HY-106635

    RP31264

    GABA Receptor Neurological Disease
    Suriclone (RP31264) is a GABA receptor agonist. Suriclone is an anxiolytic agent with a high affinity for the benzodiazepine receptors. Suriclone has oral activity .
    Suriclone
  • HY-B0227A

    RP-19583 (lysinate)

    COX Metabolic Disease Inflammation/Immunology Cancer
    Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .
    Ketoprofen (lysinate)
  • HY-RS12138

    Small Interfering RNA (siRNA) Others

    RP1 Human Pre-designed siRNA Set A contains three designed siRNAs for RP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RP1 Human Pre-designed siRNA Set A
    RP1 Human Pre-designed siRNA Set A
  • HY-RS12140

    Small Interfering RNA (siRNA) Others

    RP2 Human Pre-designed siRNA Set A contains three designed siRNAs for RP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RP2 Human Pre-designed siRNA Set A
    RP2 Human Pre-designed siRNA Set A
  • HY-RS12141

    Small Interfering RNA (siRNA) Others

    RP9 Human Pre-designed siRNA Set A contains three designed siRNAs for RP9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RP9 Human Pre-designed siRNA Set A
    RP9 Human Pre-designed siRNA Set A
  • HY-12887

    RP 73401; RPR 73401

    Phosphodiesterase (PDE) Inflammation/Immunology Cancer
    Piclamilast (RP 73401) is a phosphodiesterase 4 (PDE4) inhibitor, with IC50 values of 16 nM and 2 nM in pig aorta and eosinophil soluble, respectively .
    Piclamilast
  • HY-100160

    2-Octadecyl-1H-indole-5-carboxylic acid

    Others Cardiovascular Disease
    RP 54275 (2-Octadecyl-1H-indole-5-carboxylic acid) is a novel hypocholesterolaemic agent.
    RP 54275
  • HY-B1231

    RP-2831 hydrochloride

    Others Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    Heptaminol (RP-2831) hydrochloride is a vasoconstrictor used in the study of hypotension, especially orthostatic hypotension. Heptaminol is also a skin cancer proliferation inhibitor that inhibits immune inflammation induced by the tumor promoting factor 12-O-tetradecanoylphorbol-13-acetate (TPA) in an NO-dependent manner. Heptaminol also acts as a sympathomimetic amine, exerting indirect sympathetic effects. Heptaminol is also an antagonist of catecholamine release and uptake and can increase intracellular free calcium levels .
    Heptaminol hydrochloride
  • HY-17645
    Tenalisib
    1 Publications Verification

    RP6530

    PI3K Cancer
    Tenalisib (RP6530) is a novel, potent, and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively.
    Tenalisib
  • HY-B0227R

    RP-19583 (Standard)

    COX Metabolic Disease Inflammation/Immunology Cancer
    Ketoprofen (Standard) is the analytical standard of Ketoprofen. This product is intended for research and analytical applications. Ketoprofen (RP-19583) is a non-steroidal anti-inflammatory agent. Ketoprofen can inhibits the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity .
    Ketoprofen (Standard)

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