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Results for "

Oxidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Monoamine Oxidase (204) NADPH Oxidase (23) Protoporphyrinogen IX oxidase (5) VAP-1 (2) Xanthine Oxidase (64) 5-HT Receptor (5) Acyltransferase (1) Adenosine Receptor (2) Adrenergic Receptor (12) Akt (3) AMPK (1) Amyloid-β (2) Androgen Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (4) Apoptosis (25) Aryl Hydrocarbon Receptor (2) Autophagy (8) Bacterial (24) Bcl-2 Family (2) Biochemical Assay Reagents (6) c-Met/HGFR (6) Carbonic Anhydrase (1) Caspase (1) Cathepsin (1) Cholinesterase (ChE) (14) COMT (2) COX (2) Cytochrome P450 (5) DNA Stain (1) DNA/RNA Synthesis (1) Dopamine Receptor (3) Dopamine Transporter (2) Dopamine β-hydroxylase (2) Drug Metabolite (15) EGFR (3) Endogenous Metabolite (56) ERK (4) Estrogen Receptor/ERR (1) Ferroptosis (6) Fluorescent Dye (4) Formyl Peptide Receptor (FPR) (3) GABA Receptor (1) Guanylate Cyclase (6) HBV (1) HDAC (2) Histamine Receptor (1) Histone Demethylase (12) HIV (2) HSP (1) HSV (2) iGluR (3) Imidazoline Receptor (5) Influenza Virus (5) Isotope-Labeled Compounds (17) JAK (1) JNK (2) Liposome (1) Lipoxygenase (2) Microtubule/Tubulin (5) Mitochondrial Metabolism (2) nAChR (1) Necroptosis (1) NF-κB (1) NO Synthase (9) Nucleoside Antimetabolite/Analog (7) Opioid Receptor (1) Oxidative Phosphorylation (6) p38 MAPK (2) Parasite (10) PARP (3) Phosphatase (1) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (2) PKC (2) Ras (1) Reactive Oxygen Species (21) Reverse Transcriptase (1) Ser/Thr Protease (2) Small Interfering RNA (siRNA) (2) Sodium Channel (1) Survivin (2) Tau Protein (1) TGF-beta/Smad (2) Thrombopoietin Receptor (2) TNF Receptor (1) Toll-like Receptor (TLR) (4) TRP Channel (1) Tyrosinase (1) URAT1 (2) α-synuclein (2)
By Research Areas:	Cancer (101) Cardiovascular Disease (35) Endocrinology (13) Infection (54) Inflammation/Immunology (89) Metabolic Disease (93) Neurological Disease (183)
Click Chemistry:	Alkynes (16)
Oligonucleotides:	Nucleosides and their Analogs (4) Nucleoside Phosphoramidites (2) Phospholipids (1) siRNAs (2)

532

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Xanthine Oxidase NADPH Oxidase Monoamine Oxidase Protoporphyrinogen IX oxidase VAP-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P3263

Glutamate oxidase L-Glutamate Oxidase	Others	Others
Glutamate oxidase (L-Glutamate oxidase) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2888

Bilirubin oxidase BOD	Endogenous Metabolite	Metabolic Disease
Bilirubin oxidase (BOD) is a multi-copper oxidase that catalyzes the oxidation of bilirubin to biliverdin and reduces molecular oxygen to water. Bilirubin oxidase can participate in the metabolism of porphyrin and chlorophyll, and is widely used in biochemical research as a catalyst for oxygen reduction .

HY-150257

*Xanthine oxidase-IN-10*	Xanthine Oxidase	Others
Xanthine oxidase-IN-10 (XO8 analog) is an xanthine oxidase (XO) inhibitor .

HY-150257A

*Xanthine oxidase-IN-11*	Xanthine Oxidase	Others
Xanthine oxidase-IN-11 (XO8 analog) is an xanthine oxidase (XO) inhibitor .

HY-E70385

Oxalate Oxidase	Endogenous Metabolite	Others
Oxalate Oxidase, or oxalate oxidase, catalyzes the oxidation of oxalic acid to hydrogen peroxide and carbon dioxide in the presence of oxygen. Oxalate Oxidase can be found in a variety of plants (such as barley) and microorganisms and can be used to treat wastewater and filtrates containing oxalic acid .

HY-162961

*Xanthine oxidase-IN-16*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-16 is potent and orally active *xanthine oxidase* (XO) inhibitor with an IC₅₀** of 102 nM. Xanthine oxidase-IN-16 shows significant efficacy in hyperuricemia rats .

HY-W176012

*Glycolate oxidase-IN-1*	Others	Metabolic Disease
Glycolate oxidase-IN-1(compound 26), a salicylic acid derivative, is a glycolate oxidase (GO) inhibitor with an IC₅₀ of 38.2 μM. Glycolate oxidase-IN-1 has the ability to reduce oxalate production in hyperoxalate hepatocytes and can be used in the study of primary hyperoxaluria type 1 (PH1) .

HY-N10432

*Xanthine oxidase-IN-8* Icarisids J	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM .

HY-E70375

*Fructosyl-peptide oxidase* (FPOX-CE)** Fructosyl-peptide: oxygen oxidoreductase	Others	Others
Fructosyl-peptide oxidase (FPOX-CE) (Fructosyl-peptide: oxygen oxidoreductase) is an enzyme that catalyzes the oxidation of glycopeptides. Fructosyl-peptide oxidase (FPOX-CE) shows high activity against small molecule glycated peptides, but no activity is detected against the glycated hexapeptide standard fVHLTPE used in the study. Fructosyl-peptide oxidase (FPOX-CE) can be used in the study of diabetes monitoring .

HY-161455

*Xanthine oxidase-IN-13*	Xanthine Oxidase	Inflammation/Immunology
Xanthine oxidase-IN-13 (Compound 10) is a selective xanthine oxidase inhibitor (IC₅₀: 149.56 μM for bovine xanthine oxidase). Xanthine oxidase-IN-13 can be used for research of inflammatory arthritis .

HY-156360

*Xanthine oxidase-IN-12*	Xanthine Oxidase Reactive Oxygen Species	Inflammation/Immunology
Xanthine oxidase-IN-12 (Compound 11) is a *xanthine oxidase* (XO) inhibitor with an IC₅₀** of 91 nM. Xanthine oxidase-IN-12 also has antioxidant activity and reduces intracellular ROS .

HY-146273

*Xanthine oxidase-IN-7*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-7 (compound1h) is a potent andorally active XO (xanthine oxidase) inhibitor with an IC₅₀ of 0.36 µM. Xanthine oxidase-IN-7 effectively reduces serum uric acid levels. Xanthine oxidase-IN-7 has the potential for the research of hyperuricemia and gout .

HY-144303

*Xanthine oxidase-IN-4*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent *xanthine oxidase* (XO) inhibitor, with an IC₅₀** of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research .

HY-P2743

Choline oxidase	Biochemical Assay Reagents	Others
Choline oxidase (EC 1.1.3.17) catalyzes the oxidation of choline to glycine betaine via betaine aldehyde in glycine betaine biosynthesis and betaine acts as an osmolyte. Choline oxidase has potential in enzymatic betaine production .

HY-161514

*Xanthine oxidase-IN-15*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-15 (Compound 6c) is a selective inhibitor of *Xanthine oxidase* (XO) (IC₅₀*=0.13 μM). Xanthine oxidase-IN-15 inhibits XO catalysis by forming a stable interaction with the active site of XO. Xanthine oxidase*-IN-15 is mainly used in the study of hyperuricemia and gout .

HY-P2891

*Pyruvate Oxidase, Microorganisms* PoxB	Endogenous Metabolite	Others
Pyruvate Oxidase, Microorganisms (PoxB) is a thiamine pyrophosphate-dependent oxidase that catalyzes the oxidative decarboxylation of pyruvate to acetyl phosphate, carbon dioxide and water. Pyruvate oxidase is an important enzyme in bacterial metabolism and is often used in biochemical research .

HY-P2986

D-Amino acid oxidase	Endogenous Metabolite	Metabolic Disease
D-Amino acid oxidase is an enzyme to metabolize exogenous D-amino acids in animals for detoxifying action. D-Amino acid oxidase also modulates the level of D-serine in brain .

HY-P2742B

*Ascorbate oxidase, acremonium sp*	Endogenous Metabolite	Metabolic Disease
Ascorbate oxidase, acremonium sp is a member of the multicopper blue oxidase family and primarily exists in plants as a free enzyme in the cytoplasm or bound to the cell wall. Ascorbate oxidase, acremonium sp has a high activity in catalyzing the oxidation of ascorbic acid to dehydroascorbic acid, regulating various cellular processes related to plant growth, protection, and development. Ascorbate oxidase, acremonium sp can be used to detect hydrogen peroxide .

HY-146560

*Xanthine oxidase-IN-6*	Xanthine Oxidase NF-κB Toll-like Receptor (TLR) TNF Receptor	Metabolic Disease Inflammation/Immunology
Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity .

HY-134757

*Lactate oxidase, Microorganism*	Others	Others
Lactate oxidase (EC 1.13.12.4) belongs to a group of FMN-dependent enzymes and they catalyze a conversion of lactate to pyruvate with a release of hydrogen peroxide. Lactate oxidase can be used in the detection of Lactate .

HY-144456

*Xanthine oxidase-IN-5*	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-5 is an effective and orally active xanthine oxidase (XO) inhibitor with IC₅₀ value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model .

HY-P2987

L-Amino acid oxidase	Endogenous Metabolite	Metabolic Disease
L-Amino acid oxidase is a homodimeric proteins containing flavin adenine dinucleotide. L-Amino acid oxidase can catalyze the stereospecific oxidative deamination of L-amino acids to α-keto acids and ammonia .

HY-W560574

*Xanthine oxidase-IN-14*	Xanthine Oxidase	Cancer
Xanthine oxidase-IN-14 (Compound 3f) is an inhibitor for xanthine oxidase, with IC₅₀ >100 μM. Xanthine oxidase-IN-14 inhibits proliferations of cancer cells MCF-7, NCI-H460 and SF-268, with IC₅₀ greater than 150 μM .

HY-P2965

L-Lysine α-oxidase	Others	Cancer
L-Lysine α-oxidase is a potent anticancer agent. L-Lysine α-oxidase also a L-amino acid oxidase, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. L-Lysine α-oxidase shows cytotoxicity and anticancer activity .

HY-152026

*NADPH oxidase-IN-1*	NADPH Oxidase	Neurological Disease
NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC₅₀s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .

HY-151549

*Mtb-cyt-bd oxidase-IN-2*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-2 is an inhibitor of Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) with an IC₅₀ value of 0.67 μM. Mtb-cyt-bd oxidase-IN-2 inhibits the growth of Mycobacterium tuberculosis with a MIC value of 256 μM. Mtb-cyt-bd oxidase-IN-2 can be used for the research of infection .

HY-P2921

*Urate oxidase, Microorganism* Uox	Endogenous Metabolite	Others
Urate oxidase, Microorganism (Uox), i.e., uricase, is often used in biochemical studies. Urate oxidase is a peroxisomal enzyme that catalyzes the oxidation of uric acid to allantoin in most mammals .

HY-151548

*Mtb-cyt-bd oxidase-IN-1*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-1 (compound 1x) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.13 μM. Mtb-cyt-bd oxidase-IN-1 can be used in tuberculosis research .

HY-151550

*Mtb-cyt-bd oxidase-IN-3*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-3 (compound 1u) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.36 μM. Mtb-cyt-bd oxidase-IN-3 inhibits the growth of Mycobacterium tuberculosis (MIC=32 μM). Mtb-cyt-bd oxidase-IN-3 can be used in tuberculosis research .

HY-151551

*Mtb-cyt-bd oxidase-IN-4*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-4 (compound 1g) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC₅₀ value of 0.25 μM. Mtb-cyt-bd oxidase-IN-4 inhibits the growth of Mycobacterium tuberculosis (MIC=8 μM). Mtb-cyt-bd oxidase-IN-4 can be used in tuberculosis research .

HY-151553

*Mtb-cyt-bd oxidase-IN-6*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-6 is a potent Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC₅₀ value of 0.35 μM. Mtb-cyt-bd oxidase-IN-6 can effectively inhibit the growth of Mtb (MIC= 4 μM). Mtb-cyt-bd oxidase-IN-6 can be used in the study of tuberculosis .

HY-P3182

NADH oxidase	Others	Others
NADH oxidase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2742A

*L-Ascorbate oxidase, Cucumber*	Endogenous Metabolite	Metabolic Disease
L-Ascorbate oxidase, Cucumber belongs to the family of oxidoreductases acting on diphenols and related substances as donor with oxygen as acceptor. L-Ascorbate oxidase, Cucumber catalyses the oxidation of L‐Ascorbate (HY-B0166) with oxygen to dehydroascorbate with the generation of water. L-Ascorbate oxidase, Cucumber can be used in baking processes and cereal‐based processes .

HY-151552

*Mtb-cyt-bd oxidase-IN-5*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-5 (compound 1k) is a Mycobacterium tuberculosis (Mtb) cytochrome bd (cyt-bd) oxidase (MtbCyt-bd Oxidase) inhibitor with an IC₅₀ value of 0.37 μM. Mtb-cyt-bd oxidase-IN-5 can effectively inhibit the growth of Mtb (MIC= 256 μM). Mtb-cyt-bd oxidase-IN-5 can be used in the study of tuberculosis .

HY-P2902

Glucose oxidase 2 Publications Verification	Endogenous Metabolite	Cancer
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O₂) to produce hydrogen peroxide (H₂O₂) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation .

HY-P2910

*Galactose Oxidase, Dactylium dendroides* 1 Publications Verification GOase	Endogenous Metabolite	Others
Galactose Oxidase, Dactylium dendroides (GOase) from fungus is often used in biochemical studies. Galactose oxidase is a type II copper metalloenzyme, and it containing a single polypeptide. Galactose oxidase catalyzes two-electron oxidation of primary alcohols to their corresponding aldehydes, coupling with the reduction of dioxygen to hydrogen peroxide .

HY-P2848

*Cholesterol oxidase, Microorganism* ChOx	Endogenous Metabolite	Others
Cholesterol oxidase, Microorganism (ChOx) is a bacterial flavin oxidase containing FAD, commonly used in biochemical research. Cholesterol oxidase catalyzes the oxidation of the C(3)-OH group of cholesterol (and other sterols) to cholest-5-en-3-one and isomerizes it to cholest-4-en-3-one .

HY-151956

*Mtb-cyt-bd oxidase-IN-7*	Bacterial	Infection
Mtb-cyt-bd oxidase-IN-7 is a *cytochrome bd terminal oxidase* (Cyt-bd) inhibitor with a K_d** value of 4.17 μM. Mtb-cyt-bd oxidase-IN-7 shows anti-tuberculosis activities .

HY-22166

*Glycolic acid oxidase* inhibitor 1**	Others	Metabolic Disease
Glycolic acid oxidase inhibitor 1 is a glycolate oxidase inhibitor, extracted from patent EP0021228A1, in Table IV.

HY-144824

*Monoamine oxidase/Aromatase-IN-1*	Cytochrome P450 Monoamine Oxidase	Neurological Disease Cancer
Monoamine oxidase/Aromatase-IN-1 (compound 2q) is a highly potent *monoamine oxidase* (MAO) and aromatase dual inhibitor with IC₅₀*s of 39 nM and 31 nM for MAO-B and aromatase, respectively. Monoamine oxidase*/Aromatase-IN-1 can be used for researching neurological disorder and breast cancer .

HY-P2742

*Ascorbate oxidase, Cucurbit sp.* ASO, Cucurbit sp.	Endogenous Metabolite	Metabolic Disease
Ascorbate oxidase, Cucurbit sp., also known as vitamin C oxidase, is a REDOX enzyme involved in the regulation of extracellular matrix. Ascorbate oxidase catalyzes the reaction of ascorbic acid and oxygen to produce dehydroascorbic acid .

HY-N10433

*Xanthine oxidase-IN-9* Icarisids E	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent *xanthine oxidase* (XOD) inhibitor with an IC₅₀** of 31.81 μM .

HY-E70074

*Monoamine oxidase, plasma*	Monoamine Oxidase	Neurological Disease
Monoamine oxidase (EC 1.4.3.4) is an enzyme composed of different polypeptides. Monoamine oxidation catalyzes the oxidative deamination of various biological amines in brain and peripheral tissues by producing hydrogen peroxide. Monoamine oxidase plays an important role in maintaining the regulation of synaptic transmission, emotional behavior and other brain functions .

HY-P2733

*Glycerol-3-phosphate oxidase, E. coli* GPO	Endogenous Metabolite	Metabolic Disease
Glycerol-3-phosphate oxidase, E. coli (GPO) is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase is the skeleton of phospholipids in membrane lipids, and also a substrate in the respiratory chain. Glycerol-3-phosphate oxidase produces electrons through oxidation .

HY-P2848A

*Cholesterol oxidase, rhodococcus sp*	Toll-like Receptor (TLR)	Infection Metabolic Disease
Cholesterol oxidase, Rhodococcus sp. is a key enzyme in the cholesterol degradation process. It catalyzes the isomerization and oxidation of cholesterol mediated by the coenzyme FAD. Research indicates that cholesterol oxidase plays a crucial role in the pathogenicity of Mycobacterium tuberculosis by modulating the host macrophage immune response through inhibition of the Toll-like receptor 2 (TLR2) signaling pathway, thereby enhancing the survival of Mycobacterium tuberculosis. Cholesterol oxidase, from Rhodococcus sp., shows potential for research in the field of tuberculosis .

HY-P2758

Diamine oxidase DAO	Others	Others
Diamine oxidase (DAO) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2891A

*Pyruvate oxidase, Aerococcus viridans* PoxB, Aerococcus viridans	Endogenous Metabolite	Others
Pyruvate oxidase, Aerococcus viridans (PoxB) is a thiamine pyrophosphate-dependent oxidase that catalyzes the oxidative decarboxylation of pyruvate to produce acetyl phosphate, carbon dioxide, and water. Pyruvate oxidase, Aerococcus viridans is an important enzyme in bacterial metabolism and can enhance ATP production. Additionally, Pyruvate oxidase, Aerococcus viridans can be used for the determination of aspartate aminotransferase and alanine aminotransferase activities .

HY-162573

*Monoamine Oxidase* B inhibitor 5**	Monoamine Oxidase	Neurological Disease
Monoamine Oxidase B inhibitor 5 (Compound 16d) is a selective and reversible inhibitor for monoamine oxidase B (hMAO-B) with an IC₅₀ of 67.3 nM and a K_i of 82.5 nM. Monoamine Oxidase B inhibitor 5 exhibits good pharmacokinetic characters and weak toxicity in rats model. Monoamine Oxidase B inhibitor 5 alleviates MPTP-induced (HY-15608) motor impairment in Parkinson’s mouse model. Monoamine Oxidase B inhibitor 5 is blood-brain barrier (BBB) penetrate .

HY-143244

*Monoamine Oxidase* B inhibitor 1**	Monoamine Oxidase	Neurological Disease
Monoamine Oxidase B inhibitor 1 is a potent, reversible, orally active and selective *monoamine oxidase* B (MAO-B) inhibitor with an IC₅₀** of 0.02 nM. Monoamine Oxidase B inhibitor 1 has antioxidant and anti-neuroinflammatory activities. Monoamine Oxidase B inhibitor 1 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study .

HY-143245

*Monoamine Oxidase* B inhibitor 2**	Monoamine Oxidase	Neurological Disease
Monoamine Oxidase B inhibitor 2 is a potent, reversible, orally active and selective *monoamine oxidase* B (MAO-B) inhibitor with an IC₅₀** of 1.33 nM. Monoamine Oxidase B inhibitor 2 has antioxidant and anti-neuroinflammatory activities. Monoamine Oxidase B inhibitor 2 can across the blood-brain barrier (BBB), and can be used for Parkinson’s disease study .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N9608

6-Ketocholestanol 3β-Hydroxy-5α-cholestan-6-one	Apocynaceae Diospyros virginiana L. Source classification Plants Steroids	Others
6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. 6-Ketocholestanol increases the membrane dipole potential .

HY-N9329

Glicoricone	Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Isoflavones	Monoamine Oxidase Estrogen Receptor/ERR
Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of *monoamine oxidase* (MAO), with an IC₅₀ of 140 μM. Glicoricone binds to estrogen receptor (ER)** and shows estrogen antagonist activity .

HY-13675

ME-143 NV-143	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
ME-143 is a second-generation tumor-specific inhibitor of NADH oxidase. ME-143 inhibits the WNT/β-catenin pathway in colorectal cancer cells. ME-143 has broadly active against cancers in vitro and in vivo .

HY-N9540

Methyl citrate	Cactaceae Ketones, Aldehydes, Acids Source classification Opuntia ficus-indica (L.) Mill. Plants	Monoamine Oxidase
Methyl citrate is a Monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.23 mM). Methyl citrate is isolated from the fruits of Opuntia ficus-indica var. saboten Makino .

HY-N10432

*Xanthine oxidase-IN-8* Icarisids J	Flavonols Flavonoids Juglandaceae Source classification Cyclocarya paliurus (Batal.) Iljinsk. Plants	Xanthine Oxidase
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM .

HY-N10433

*Xanthine oxidase-IN-9* Icarisids E	Flavonoids Juglandaceae Source classification Cyclocarya paliurus (Batal.) Iljinsk. Plants	Xanthine Oxidase
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent *xanthine oxidase* (XOD) inhibitor with an IC₅₀** of 31.81 μM .

HY-N7397

Forsythoside F Arenarioside	Classification of Application Fields Oleaceae Simple Phenylpropanols Source classification Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Forsythia suspensa (Thunb.) Vahl Disease Research Fields	Xanthine Oxidase
Forsythoside F (Arenarioside) is a xanthine oxidase inhibitor and possesses antihyperuricemic effects in vivo .

HY-N12916

Dihydrogeodin	Structural Classification Microorganisms Source classification Phenols Polyphenols	Others
Dihydrogeodin is a substrate of dihydrodixin oxidase and can be isolated from Aspergillus terreus .

HY-119596

Eupatoriochromene	Structural Classification Monophenols Source classification Phenols Helianthella quinquenervis (Hook.) A.Gray Plants Compositae	Xanthine Oxidase
Eupatoriochromene is a chromene and has inhibitory activity against *xanthine oxidase* (XO)** .

HY-N10741

Ellagic acid 4-O-β-D-xylopyranoside	Structural Classification Natural Products Source classification Plants Cunoniaceae Cunonia macrophylla Brongn. & Gris	Xanthine Oxidase Bacterial
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an xanthine oxidase inhibitor with an ₅₀ of 2.1 μg/mL .

HY-P99047

Simtuzumab AB 0024; GS 6624	Classification of Application Fields Disease Research Fields Cancer	Monoamine Oxidase
Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab can be used for the research of primary sclerosing cholangitis (PSC) .

HY-N13185

POPi	Structural Classification Malus pumila Mill. Source classification Rosaceae Phenols Polyphenols Plants	Endogenous Metabolite
POPi (phloridzin oxidation product i) is a colorless oxidation product of phloridzin catalyzed by the apple polyphenol oxidase with DPPH radicalscavenging activity. POPi can be utilized in antioxidant research .

HY-W041301

(±)-Dihydroactinidiolide	Natural Products Classification of Application Fields Nicotiana tabacum L. Source classification Other Diseases Plants Solanaceae Disease Research Fields	Others
(±)-Dihydroactinidiolide, an important aroma compound of black tea and tobacco, has been isolated from several plants. (±)-Dihydroactinidiolide can be formation from β-Carotene by the treatment of polyphenoloxidase, the lipoxygenase, and the xanthine oxidase .

HY-N1162

Tetrahydroamentoflavone Amentoflavanone	Structural Classification Flavonoids Source classification Plants Biflavones Semecarpus anacardium L.f. Anacardiaceae	Xanthine Oxidase
Tetrahydroamentoflavone (Amentoflavanone) is a potent *xanthine oxidase* (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC₅₀ and K_i** values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout .

HY-129137

Cyanidin 3-sophoroside chloride Cy 3-soph	Rosaceae Plants Prunus cerasus L.	Others
Cyanidin 3-sophoroside chloride is a potent non-competitive reversible polyphenol oxidase (PPO) inhibitor. Also, Cyanidin 3-sophoroside chloride can be used as an anti-browning agent to inhibit the degree of PPO browning, enhance the antioxidant damage capacity of fruits and prolong the storage period .

HY-W014502

D-Kynurenine	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Aryl Hydrocarbon Receptor Endogenous Metabolite
D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR) .

HY-Y1750

β-Aminopropionitrile 2 Publications Verification BAPN	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Monoamine Oxidase Endogenous Metabolite
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active *lysyl oxidase* (LOX)** inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes .

HY-Y1750A

β-Aminopropionitrile hydrochloride BAPN hydrochloride	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Monoamine Oxidase Endogenous Metabolite
β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active *lysyl oxidase* (LOX)** inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes .

HY-113056A

N1-Acetylspermidine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA .

HY-N1636

1-Methyl-2-nonyl-4(1H)-quinolone	Alkaloids Neurological Disease Classification of Application Fields Source classification Rutaceae Quinoline Alkaloids Plants Disease Research Fields	Monoamine Oxidase
1-Methyl-2-nonyl-4(1H)-quinolone, a quinolone alkaloid, is a potent and selective MAO-B (monoamine oxidase) inhibitor. 1-Methyl-2-nonyl-4(1H)-quinolone exhibites inhibitory activity on leukotriene biosynthesis, with an IC₅₀ of 12.1 μM .

HY-W018555

D-Cysteine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Source classification Amino acids Endogenous metabolite	Endogenous Metabolite Bacterial
D-Cysteine is the D-isomer of cysteine and a powerful inhibitor of *Escherichia coli* growth. D-cysteine is mediated by D-amino acid oxidase to produce H₂S and is a neuroprotectant against cerebellar ataxias. D-Cysteine could inhibit the growth and cariogenic virulence of dual-species biofilms formed by *S. mutans* and *S. sanguinis* .

HY-N0327

Lobetyolin 2 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Campanulaceae Metabolic Disease Codonopsis pilosula Plants Disease Research Fields	Apoptosis Xanthine Oxidase
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism . Lobetyolin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-116688

2-Hydroxy-4-(methylthio)butyric acid	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
2-Hydroxy-4-(methylthio)butyric acid is a dietary essential amino acid which is converted to Methionine (HY-13694) by 2-hydroxy acid dehydrogenase and 2-hydroxy acid oxidase. 2-Hydroxy-4-(methylthio)butyric acid is promising for research of gut disease .

HY-W008566

Norharmane Norharman; β-Carboline	Structural Classification Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Biological Pesticide Research Indole Alkaloids Agricultural Research Infection Alkaloids Microorganisms Disease Research Fields Cancer	Monoamine Oxidase Endogenous Metabolite
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

HY-W008566R

Norharmane (Standard)	Alkaloids Structural Classification Microorganisms Source classification Pyridine Alkaloids Endogenous metabolite Indole Alkaloids	Monoamine Oxidase Endogenous Metabolite
Norharmane (Standard) is the analytical standard of Norharmane. This product is intended for research and analytical applications. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

HY-N1638

1-Methyl-2-undecyl-4(1H)-quinolone	Alkaloids Structural Classification Evodia rutaecarpa (Juss.) Benth. Source classification Rutaceae Quinoline Alkaloids Plants	Monoamine Oxidase
1-Methyl-2-undecyl-4(1H)-quinolone is a potent, irreversible and selective inhibitor of type B monoamine oxidase (MAO-B). 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of MAO-B activity with the IC₅₀ and K_i values of 15.3 μM and 9.91 μM, respectively, but did not inhibit type A MAO (MAO-A) activity. Methyl-2-undecyl-4(1H)-quinolone, as a quinolone alkaloid, is isolated from fresh leaves and fruits of Evodia rutaecarpa HOOK. f. et THOMS .

HY-N13041

Acacetin 7-O-(6-O-malonylglucoside)	Structural Classification Flavonoids Flavones Labiatae Source classification Agastache rugosa (Fisch. & C. A. Mey.) Kuntze Plants	Monoamine Oxidase
Acacetin 7-O-(6-O-malonylglucoside) is a monoamine oxidase inhibitor with strong inhibitory effects on monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC₅₀ values of 2.34 and 1.87 μM, respectively. Acacetin 7-O-(6-O-malonylglucoside) is a reversible MAO inhibitor that can be used in the research of neurodegenerative diseases and affective disorders .

HY-N9330

Broussoflavonol F	Flavonols Flavonoids other families Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Xanthine Oxidase
Broussoflavonol F possess xanthine oxidase inhibitory activity .

HY-Y0127

D(-)-2-Aminobutyric acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

HY-W018324

5-Hydroxymethylcytosine 5hmC	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development .

HY-22385A

Salsolidine hydrochloride	Alkaloids other families Source classification Plants Isoquinoline Alkaloids	Monoamine Oxidase
Salsolidine hydrochloride, a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive *MAO A (monoamine oxidase* A)** inhibitor.

HY-I0637

Isovanillin 3-Hydroxy-4-methoxybenzaldehyde	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Asclepiadaceae Phenols Plants Periploca sepium Bunge	Others
Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-N3906

Fraxamoside	Structural Classification Oleaceae Source classification Phenols Polyphenols Plants Fraxinus americana L.	Xanthine Oxidase
Fraxamoside is a competitive xanthine oxidase inhibitor with an IC₅₀ of 16.1 μM and a K_i of 0.9 μM .

HY-N8315

Echitovenidine	Apocynaceae Structural Classification Alkaloids Alstonia yunnanensis Diels Source classification Plants	Monoamine Oxidase
Echitovenidine is an alkaloid that can be isolated from Alstonia yunnanensis. Echitovenidine is an inhibitor of *monoamine oxidase* (MAO)** .

HY-N3614

Confluentic acid	Structural Classification Natural Products Microorganisms Source classification	Others
Confluentic acid exhibits selective inhibition of Monoamine oxidase B, demonstrating an IC50 value of 0.22 micromolar.

HY-N0196

Baicalein Maximum Cited Publications 21 Publications Verification 5,6,7-Trihydroxyflavone	Structural Classification Classification of Application Fields Flavones Anti-aging Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Labiatae Phenols Polyphenols Medicago truncatula Gaertn. Disease Research Fields Cancer	Xanthine Oxidase Influenza Virus Ferroptosis
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC₅₀ value of 3.12 μM.

HY-101392

Harmane 1 Publications Verification	Alkaloids Structural Classification other families Source classification Pyridine Alkaloids Plants Indole Alkaloids	Imidazoline Receptor Monoamine Oxidase Adrenergic Receptor nAChR GABA Receptor Opioid Receptor
Harmane is an inhibitor that binds to benzodiazepine receptors (with an IC₅₀ value of 7 μM), has an IC₅₀ of 24 μM for muscarinic acetylcholine receptors (QNB), an IC₅₀ of 2.8 μM for opioid receptors, and IC₅₀ values of 163 and 101 μM for spironolactone and serotonin, respectively. Harmane is a selective monoamine oxidase inhibitor (with IC₅₀ values of 0.5 μM for MAO A and 5 μM for MAO B). Harman inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing levodopa (L-DOPA)-induced toxicity in PC12 cells. Harmane lowers blood pressure in rats through the I1 imidazoline receptor (I1 receptor) and has antidepressant, anxiolytic, anticonvulsant, and analgesic effects. Harmane enhances the mutagenicity induced by 2-acetylaminofluorene (AAF) .

HY-W004570

5-Nitro-1,10-phenanthroline 5-NP	Infection Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields	Endogenous Metabolite
5-Nitro-1,10-phenanthroline (5-NP), is a o-Phenanthroline (HY-W004544) derivative, as a mediator of glucose oxidase (GOX) with antituberculous activity. 5-Nitro-1,10-phenanthroline can be applied as redox mediators for oxidases and is suitable for the development of reagent-less biosensors and biofuel cells .

HY-N2697

6-Acetonyl-N-methyldihydrodecarine	Structural Classification Alkaloids Source classification Zanthoxylum rigidum Humb. & Bonpl. ex Willd. Rutaceae Plants Isoquinoline Alkaloids	Monoamine Oxidase
6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid that can be isolated from roots of Zanthoxylum rigidum. An inhibitor of monoamine oxidases .

HY-125515

Tetrahydroharmine Leptaflorine	Structural Classification Alkaloids Banisteriopsis caapi (Spruce ex Griseb.) Morton Source classification Malpighiaceae Plants Indole Alkaloids	Monoamine Oxidase
Tetrahydroharmine (Leptaflorine) is A monoamine oxidase (MAO) inhibitor with a IC₅₀ value of 74 nM for MAO-A. Tetrahydroharmine can be used in the study of neurodegenerative diseases .

HY-19657

Oxypurinol Oxipurinol	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Drug Metabolite Endogenous Metabolite Xanthine Oxidase
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-N8600

7,8,3′,4′-Tetrahydroxyflavone	Structural Classification Flavonoids Flavones Leguminosae Source classification Plants Acacia confusa Merr.	Xanthine Oxidase
7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent *xanthine oxidase* (XOD) inhibitor with an IC₅₀** value of 10.488 µM .

HY-108844

Rasburicase	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Rasburicase is a recombinant urate oxidase and a hyperuricemia inhibitor. Rasburicase converts uric acid into allantoin, making it easier to be cleared by the kidneys and improving the elevated level of uric acid in the blood .

HY-N1547

Prudomestin	Flavonols Structural Classification Flavonoids Classification of Application Fields Source classification Rosaceae Phenols Polyphenols Prunus domestica L. Plants Inflammation/Immunology Disease Research Fields	Xanthine Oxidase
Prudomestin, isolated from the heartwood of Prunus domestica, shows potent *xanthine oxidase* (XO)** inhibitory activity (IC₅₀≈6 µM) .

HY-I0637R

Isovanillin (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Asclepiadaceae Phenols Plants Periploca sepium Bunge	Others
Isovanillin (Standard) is the analytical standard of Isovanillin. This product is intended for research and analytical applications. Isovanillin is an aldehyde oxidase inhibitor . Antispasmodic activities . Antidiarrheal activities .

HY-N7603

Rubrofusarin triglucoside	Seeds of Cassia tora Linn. Monophenols other families Leguminosae Ketones, Aldehydes, Acids Source classification Phenols Plants	Monoamine Oxidase
Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits *human monoamine oxidase* A (hMAO-A) with an IC₅₀** of 85.5 μM .

HY-22385B

(S)-Salsolidine	Alkaloids Structural Classification Source classification Salsola Plants Isoquinoline Alkaloids Chenopodiaceae	Monoamine Oxidase Endogenous Metabolite
(S)-Salsolidine is a weak *monoamine oxidase* (MAO) inhibitor (K_i**=63 μM). The R enantiomer of Salsolidine is more potent than the S form (K_i=26 μM) .

HY-N0196R

Baicalein (Standard)	Structural Classification Human Gut Microbiota Metabolites Flavonoids Flavones Labiatae Source classification Phenols Polyphenols Plants Endogenous metabolite Medicago truncatula Gaertn.	Xanthine Oxidase Influenza Virus Ferroptosis
Baicalein (Standard) is the analytical standard of Baicalein. This product is intended for research and analytical applications. Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.

HY-N9324

Ilexoside O	Aquifoliaceae Triterpenes Classification of Application Fields Terpenoids Source classification Ilex pubescens Hook. et Arn. Plants Disease Research Fields Inflammation/Immunology	Xanthine Oxidase
Ilexoside O is a triterpene saponin isolated from the roots of Ilex pubescens. Ilexoside O exhibits weak *xanthine oxidase* (XOD)** inhibitory activity (IC₅₀=53.05 μM) .

HY-N10863

Aurantiamide benzoate	Structural Classification Alkaloids Source classification Celastraceae Pyridine Alkaloids Celastrus rugosus Rehd. et Wils. Plants	Xanthine Oxidase
Aurantiamide benzoate is a nature product that could be isolated from two tropical medicinal plants, Cunila spicata and Hyptis fasciculata. Aurantiamide benzoate is a potent xanthine oxidase inhiobitor with an IC₅₀ value of 70 μM .

Cat. No.	Product Name	Chemical Structure

HY-14268S

Febuxostat-d9
Febuxostat-d₉ is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.

HY-B0219S

Allopurinol-d2
Allopurinol-d₂ is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

HY-B0203BS2

(Rac)-Nebivolol-d2,15N

(Rac)-Nebivolol-d₂, ¹⁵N is ¹⁵N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

HY-B0831S

Buprofezin-d6

Buprofezin-d₆ is the deuterium labeled Buprofezin. Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets developmental stage coleopteran pests.Buprofezin promotes the conversion of energy metabolism from the aerobic tricarboxylic acid (TCA) cycle and oxidative phosphorylation to anaerobic glycolysis. Buprofezin also promotes the production of reactive oxygen species (ROS) by inhibiting cytochrome c oxidase[1][2].

HY-14268S1

Febuxostat-d7
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1].

HY-N0088S

Apocynin-d3
Apocynin-d₃ is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].

HY-I0637S

Isovanillin-d3
Isovanillin-d₃ is the deuterium labeled Isovanillin[1]. Isovanillin is an aldehyde oxidase inhibitor[2]. Antispasmodic activities[3]. Antidiarrheal activities[4].

HY-Y0127S

D(-)-2-Aminobutyric acid-d6
D(-)-2-Aminobutyric acid-d₆ is the deuterium labeled D(-)-2-Aminobutyric acid. D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

HY-Y0882S1

Hydroxylamine-d3 hydrochloride
Hydroxylamine-d₃ (hydrochloride) is the deuterium labeled Hydroxyamine hydrochloride[1]. Hydroxyamine hydrochloride is a selective monoamine oxidase (MAO) inhibitor used for inhibiting of platelet aggregation. Hydroxyamine hydrochloride is an intermediate of organic synthesis[2].

HY-B1111S1

Amitraz-d3
Amitraz-d₃ is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

HY-W725473

Oxyfluorfen-d5
Oxyfluorfen-d₅ is deuterated labeled Oxyfluorfen (HY-119176) Oxyfluorfen is a pre- and post-emergence diphenyl ether herbicide to control annual broad-leaved and grass weeds. Oxyfluorfen is a protoporphyrinogen oxidase inhibitor and inhibits photosynthesis by blocking chlorophyll synthesis.

HY-19657S

Oxypurinol-13C,15N2
Oxypurinol- ¹³C, ¹⁵N₂ is ¹⁵N and ¹³C labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout .

HY-B0534S1

Moclobemide-d4
Moclobemide-d₄ is deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A[1].Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-W015490S

1,4-Naphthoquinone-d6
1,4-Naphthoquinone-d₆ is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].

HY-B2010S

Fomesafen-d3
Fomesafen-d₃ is the deuterium-labeled Fomesafen (HY-B2010). Fomesafen-d₃ is a type of efficient and selective *protoporphyrinogen IX oxidase* (PPO)** inhibitor. Fomesafen-d₃ is a herbicide and has the advantages of low toxicity and high selectivity .

HY-B1111S

Amitraz-d6
Amitraz-d6 (BTS-27419-d6) is the deuterium labeled Amitraz. Amitraz is a non-systemic acaricide and insecticide, with alpha-adrenergic agonist activity, interaction with octopamine receptors of the central nervous system and inhibition of monoamine oxidases and prostaglandin synthesis.

HY-50683S

JNJ-38877605-d1
JNJ-38877605-d1 (compound DO-2) is a highly selective MNNG HOS transforming (MET) inhibitor. JNJ-38877605-d1 is thought to diminish the formation of the Aldehyde Oxidase 1 inactive metabolite M3 .

HY-17447SA

Tranylcypromine-d5 hydrochloride

Tranylcypromine-d₅ (hydrochloride) is a deuterium labeled (rel)-Tranylcypromine hydrochloride. Tranylcypromine hydrochloride is an irreversible, nonselective monoamine oxidase (MAO) inhibitor used in the treatment of depression. Tranylcypromine hydrochloride is also a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis[1][2].

HY-B0534S

Moclobemide-d8
Moclobemide-d₈ (Ro111163-d₈) is the deuterium labeled Moclobemide. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC₅₀ of 6.061 μM for hMAO-A .Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

HY-14605BS

Rasagiline-13C3 mesylate racemic

Rasagiline- ¹³C₃ (mesylate racemic) is a ¹³C-labeled Rasagiline mesylate racemic. Rasagiline mesylate racemic is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor[1]. Rasagiline-13C3 (mesylate racemic) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-121246S

Fluorofenidone-d3
Fluorofenidone-d₃ is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].

HY-14605S

Rasagiline-13C3 mesylate
Rasagiline- ¹³C₃ ((R)-AGN1135- ¹³C₃; TVP1012- ¹³C₃) mesylateis the deuterium labeledRasagiline (mesylate)(HY-14605) . Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43?nM and 412?nM for rat brain MAO B and A activity, respectively .

HY-113056AS

N1-Acetylspermidine-d6 hydrochloride

N1-Acetylspermidine-d₆ (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA[1][2][3].

HY-13653S

(+/-)-Epigallocatechin Gallate-13C3

(+/-)-Epigallocatechin Gallate- ¹³C₃ is the ¹³C-labeled (-)-Epigallocatechin Gallate. (-)-Epigallocatechin Gallate is a tea flavonoid with potent antioxidant, antiinflammatory, and anticarcinogenic properties. (-)-Epigallocatechin Gallate is reported to inhibit EGFR signaling and thereby exert anticancer effects[1]. (-)-Epigallocatechin Gallate (EGCG) is a glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) inhibitor. Epigallocatechin-3-gallate induces oxidative phosphorylation (OXPHOS) by activating cytochrome c oxidase.

HY-17447AS

(1S,2R)-Tranylcypromine-d5 hydrochloride

(1S,2R)-Tranylcypromine-d₅ (hydrochloride) is the deuterium labeled Tranylcypromine hydrochloride[1]. Tranylcypromine hydrochloride (SKF 385 hydrochloride) is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Tranylcypromine hydrochloride inhibits LSD1, MAO A and MAO B with IC50s of 20.7, 2.3 and 0.95 μM, respectively. Tranylcypromine hydrochloride can be used for the research of depression[2][3][4].

HY-101392S

Harmane-d1

Harmane-d is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-101392S1

Harmane-d2

Harmane-d₂ is the deuterium labeled Harmane. Harmane, a β-Carboline alkaloid (BCA), is a potent neurotoxin that causes severe action tremors and psychiatric manifestations. Harmane shows 1000-fold selectivity for I1-Imidazoline receptor (IC50=30 nM) over α2-adrenoceptor (IC50=18 μM). Harmane is also a potent and selective inhibitor of monoamine oxidase (MAO) (IC50s=0.5 and 5 μM for human MAO A/B, respectively)[1][2][3][4].

HY-70057S1

Safinamide-d4-1

Safinamide-d₄-1 is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM)[1]. Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al[2][3].

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