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Results for "

cereblon E3 ligase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E1/E2/E3 Enzyme (4) E3 Ligase Ligand-Linker Conjugates (258) Ligands for E3 Ligase (76) Aldose Reductase (1) Androgen Receptor (3) Apoptosis (150) Aurora Kinase (1) Autophagy (166) Bcl-2 Family (1) BCL6 (1) Btk (5) c-Myc (1) CDK (4) EGFR (1) Epigenetic Reader Domain (4) Estrogen Receptor/ERR (1) FAK (1) FKBP (1) FLT3 (1) HDAC (1) Histone Methyltransferase (1) IKZF Family (1) Indoleamine 2,3-Dioxygenase (IDO) (2) Isotope-Labeled Compounds (5) Itk (1) Kinesin (1) MDM-2/p53 (1) Molecular Glues (20) mTOR (1) NF-κB (2) p38 MAPK (1) PARP (1) PROTAC Linkers (1) PROTACs (40) Ras (3) Sirtuin (1) STAT (1) YAP (1) α-synuclein (1)
By Research Areas:	Cancer (365) Endocrinology (1) Inflammation/Immunology (20) Neurological Disease (1)
Click Chemistry:	PROTAC Synthesis (1) Azide (19) Alkynes (2)

378

Inhibitors & Agonists

Screening Libraries

Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: Ligands for E3 Ligase E3 Ligase Ligand-Linker Conjugates E1/E2/E3 Enzyme

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130521

Pomalidomide-amido-PEG3-C2-NH2 cereblon Ligand-Linker Conjugates 22; E3 ligase Ligand-Linker Conjugates 55	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology .

HY-103612

Thalidomide-O-amido-C3-COOH cereblon Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 15	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-21930

Pomalidomide-PEG4-C-COOH cereblon Ligand -Linker Conjugates 1; E3 ligase Ligand-Linker Conjugates 1	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG4-C-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

HY-41549

Pomalidomide-PEG4-Ph-NH2 cereblon Ligand-Linker Conjugates 9; E3 ligase Ligand-Linker Conjugates 2	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

HY-103614

Thalidomide-O-amido-C8-NH2 TFA 1 Publications Verification cereblon Ligand -Linker Conjugates 2 TFA; E3 ligase Ligand-Linker Conjugates 20 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Others
Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-115560

Thalidomide-O-amido-C3-NH2 cereblon Ligand-Linker Conjugates 16; E3 ligase Ligand-Linker Conjugates 52	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-107439

Thalidomide-O-amido-C8-NH2 cereblon Ligand-Linker Conjugates 2; E3 ligase Ligand-Linker Conjugates 20	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C8-NH2 (Cereblon Ligand-Linker Conjugates 2), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs .

HY-107438

Thalidomide-O-amido-C4-NH2 cereblon Ligand-Linker Conjugates 6; E3 ligase Ligand-Linker Conjugates 19	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs .

HY-112618

Thalidomide-O-amido-C6-NH2 cereblon Ligand-Linker Conjugates 11; E3 ligase Ligand-Linker Conjugates 25	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C6-NH2 (Cereblon Ligand-Linker Conjugates 11), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs .

HY-128716B

Pomalidomide-PEG3-C2-NH2 hydrochloride cereblon Ligand-Linker Conjugates 5 hydrochloride; E3 ligase Ligand-Linker Conjugates 30 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-103613

Thalidomide-O-amido-C4-NH2 TFA cereblon Ligand-Linker Conjugates 6 TFA; E3 ligase Ligand-Linker Conjugates 19 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Others
Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-128716

Pomalidomide-PEG3-C2-NH2 cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

HY-112599

Pomalidomide-PEG4-C2-NH2 cereblon Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 22	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG4-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

HY-115560A

Thalidomide-O-amido-C3-NH2 TFA cereblon Ligand-Linker Conjugates 16 TFA; E3 ligase Ligand-Linker Conjugates 52 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-125884

Pomalidomide-amido-C4-amido-C6-NH-Boc cereblon Ligand-Linker Conjugates 21; E3 ligase Ligand-Linker Conjugates 54	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-amido-C4-amido-C6-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-112618A

Thalidomide-O-amido-C6-NH2 TFA cereblon Ligand-Linker Conjugates 11 TFA; E3 ligase Ligand-Linker Conjugates 25 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs .

HY-107440

Thalidomide-O-amido-PEG3-C2-NH2 cereblon Ligand-Linker Conjugates 3 ; E3 ligase Ligand-Linker Conjugates 14	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

HY-W145436

Thalidomide-Piperazine 5-fluoride hydrochloride	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis .

HY-112617A

Thalidomide-O-amido-PEG2-C2-NH2 TFA cereblon Ligand-Linker Conjugates 10 TFA; E3 ligase Ligand-Linker Conjugates 24 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Inflammation/Immunology Cancer
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

HY-103611

Thalidomide-O-amido-PEG3-C2-NH2 TFA cereblon Ligand-Linker Conjugates 3 TFA; E3 ligase Ligand-Linker Conjugates 14 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

HY-125883

Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc cereblon Ligand-Linker Conjugates 20; E3 ligase Ligand-Linker Conjugates 53	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-amido-C4-amido-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

HY-143715

Cereblon inhibitor 1	Ligands for E3 Ligase	Cancer
Cereblon inhibitor 1, an isoindoline derivative, is a cereblon E3 ubiquitin ligase modulating agent. Cereblon inhibitor 1 has the potential for cancer research.

HY-112600

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 cereblon Ligand-Linker Conjugates 12; E3 ligase Ligand-Linker Conjugates 23	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-128716A

Pomalidomide-PEG3-C2-NH2 TFA cereblon Ligand-Linker Conjugates 5 TFA; E3 ligase Ligand-Linker Conjugates 30 TFA	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs .

HY-128848

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH cereblon Ligand-Linker Conjugates 14; E3 ligase Ligand-Linker Conjugates 49	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-169357

Acepromazine-1-Piperazinepropanamine	E3 Ligase Ligand-Linker Conjugates	Cancer
Acepromazine-1-Piperazinepropanamine (compound 10) is a synthesized E3 ligase ligand-linker conjugate (E3 Ligase Ligand-Linker Conjugate) that incorporates a cereblon ligand and a linker. Acepromazine-1-Piperazinepropanamine can be connected to the target protein ligand to form a PROTAC molecule, TrimTAC1 (HY-169355) .

HY-136156

Pomalidomide-PEG6-butyl iodide	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG6-butyl iodide is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology .

HY-112600A

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA cereblon Ligand-Linker Conjugates 12 TFA; E3 ligase Ligand-Linker Conjugates 23 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

HY-103615

Thalidomide-O-amido-C4-N3 1 Publications Verification cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-133799

Pomalidomide-C7-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C7-COOH is a synthesized *E3 ligase* cereblon ligand-linker conjugate**. Pomalidomide-C7-COOH is an intermediate for the synthesis of PROTAC BCL-XL degraders .

HY-125843

Pomalidomide-PEG1-C2-N3 cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-100507

Avadomide 5+ Cited Publications CC 122	E1/E2/E3 Enzyme Apoptosis Molecular Glues NF-κB	Inflammation/Immunology Cancer
Avadomide is an orally active *cereblon* modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities .

HY-43722

Lenalidomide-Br	Ligands for E3 Ligase	Cancer
Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602) .

HY-100507A

Avadomide hydrochloride CC 122 hydrochloride	E1/E2/E3 Enzyme Apoptosis Molecular Glues NF-κB	Inflammation/Immunology Cancer
Avadomide hydrochloride (CC 122 hydrochloride) is the hydrochloride form of Avadomide (HY-100507). Avadomide hydrochloride is an orally active *cereblon* modulator. Avadomide hydrochloride modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide hydrochloride exhibits potent antitumor and immunomodulatory activities .

HY-101291

Iberdomide 5+ Cited Publications CC-220	Ligands for E3 Ligase Apoptosis Molecular Glues	Inflammation/Immunology Cancer
Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC₅₀ of ~150 nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities .

HY-W733176

E3 ligase Ligand 50	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 50 is the ligand for E3 ligase Cereblon. E3 ligase Ligand 50 can be used for synthesis of PROTAC BTK Degrader-10 (HY-160966) .

HY-W890189

E3 ligase Ligand 54	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 54 is the ligand for E3 ligase Cereblon and can be used for synthesis of PROTAC Degrader SJ44236 (HY-170900) .

HY-W247437

E3 ligase Ligand 56	Ligands for E3 Ligase	Cancer
E3 ligase Ligand 56 is the ligand for E3 ligase Cereblon and can be used for syntheisis of PROTAC CDK9 degrader-11 (HY-170978) .

HY-153357

NRX-0492	PROTACs Btk	Cancer
NRX-0492 is an orally active PROTAC-class BTK degrader. NRX-0492 catalyzes BTK ubiquitination and proteasome degradation (DC₅₀ ≤ 0.2 nM, DC₉₀ ≤ 0.5 nM) . NRX-0492 inhibits B cell receptor (BCR) mediated signaling, transcription programs, and chemokine secretion. NRX-0492 can bind non-covalently to the BTK binding domain and cereblon, which is an adapter protein in the E3 ubiquitin ligase complex . NRX-0492 consists of a target protein ligand (red part) BTK-IN-40 (HY-170324), an E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383), and a PROTAC linker (black part) (3R)-3-Pyrrolidinemethanol (HY-60263). E3 ubiquitin ligase and linker can form Thalidomide 5-pyrrolidine-CHO (HY-49372A); the active control for the target protein ligand is BTK ligand 12 (HY-49421).

HY-153321

NX-5948 BTK-IN-24	Btk PROTACs	Inflammation/Immunology Cancer
NX-5948 (BTK-IN-24) is an orally active chimeric targeting molecule (CTM) that induces specific BTK protein degradation by the cereblon E3 ligase (CRBN) complex without degradation of other cereblon neo-substrates. NX-5948 mediates potent anti-inflammatory activity via BTK degradation with resultant inhibition of B cell activation. NX-5948 exhibits potent tumor growth inhibition in TMD8 xenograft models that contain either wild-type BTK or BTKi-resistant mutations. NX-5948 is efficacious in a mouse collageninduced arthritis (CIA) model. NX-5948 can cross the blood brain barrier (BBB). NX-5948 is a PROTAC composed of the ligand for target protein, a linker, and a cereblon E3 ligase (CRBN) complex (Red: ligand for target protein; Blue: CRBN; Black: linker) .

HY-168911

E3 Ligase Ligand-linker Conjugate 168	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 168 is a conjugate composed of E3 ligase Cereblon ligand (HY-W249500) and a linker. E3 Ligase Ligand-linker Conjugate 168 can be used for synthesis of PROTAC c-Met degrader-3 (HY-168910) .

HY-157756

E3 Ligase Ligand-linker Conjugate 104	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 104 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 104 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162197

E3 ligase Ligand-Linker Conjugate 41	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 41 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 41 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157600

E3 ligase Ligand-Linker Conjugate 66	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 66 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase* Ligand-Linker Conjugate 66 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157747

E3 Ligase Ligand-linker Conjugate 99	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 99 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 99 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157748

E3 Ligase Ligand-linker Conjugate 100	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 100 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 100 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162180

E3 Ligase Ligand-linker Conjugate 2	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 2 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 2 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162203

E3 Ligase Ligand-linker Conjugate 51	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 51 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 51 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162190

E3 Ligase Ligand-linker Conjugate 17	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 17 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 17 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162192

E3 Ligase Ligand-linker Conjugate 20	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 20 is a *conjugate of E3 ligase* ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase* Ligand-linker Conjugate 20 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

Cat. No.	Product Name

HY-L128

E3 Ligase Ligand Library

65 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation.

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 65 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

Cat. No.	Product Name	Chemical Structure

HY-10984S2

Pomalidomide-d4
Pomalidomide-d₄ is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors<

HY-10984S1

Pomalidomide-d3
Pomalidomide-d₃ is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors[1][2].

HY-A0003S

Lenalidomide-d5

Lenalidomide-d₅ is deuterium labeled Lenalidomide. Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells[1][2].

HY-A0003S2

Lenalidomide-13C5,15N

Lenalidomide- ¹³C₅, ¹⁵N is ¹⁵N and ¹³C labeled Lenalidomide (HY-A0003). Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells .

HY-10984S

Pomalidomide-d5
Pomalidomide-d₅ is deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.

HY-10984S3

Pomalidomide-15N,13C5
Pomalidomide- ¹⁵N, ¹³C₅ is ¹⁵N and ¹³C labeled Pomalidomide (HY-10984). Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.

HY-14658S

Thalidomide-d4
Thalidomide-d₄ is a deuterium labeled Thalidomide. Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a Kd of ~250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties[1][2].

Cat. No.	Product Name		Classification

HY-103615

Thalidomide-O-amido-C4-N3 1 Publications Verification cereblon Ligand-Linker Conjugates 4; E3 ligase Ligand-Linker Conjugates 18		Azide
Thalidomide-O-amido-C4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-amido-C4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-125843

Pomalidomide-PEG1-C2-N3 cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50		Azide PROTAC Synthesis
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-126458

Thalidomide-O-PEG2-propargyl E3 ligase Ligand-Linker Conjugates 32		Alkynes
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Thalidomide-O-PEG2-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-148556

Thalidomide-O-C6-azide		Azide
Thalidomide-O-C6-azide is a synthesized *E3 ligase* ligand-linker conjugate** (E3 Ligase Ligand-Linker Conjugates) that incorporates the Thalidomide (Thalidomide (HY-14658)) based cereblon ligand and a linker used in PROTAC technology . Thalidomide-O-C6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-172361

Thalidomide-F-NH-C6-adize		Azide
Thalidomide-F-NH-C6-adize is the conjugate of an E3 ligase (Cereblon) ligand and a linker, and can be used for synthesis of PROTAC HDAC6 degrader 4 (HY-172359) .

HY-157511

Thalidomide-O-C5-azide		Azide
Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157510

Thalidomide-O-C3-azide		Azide
Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157515

Thalidomide 4'-ether-PEG2-azide		Azide
Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-139341

Pomalidomide 4'-alkylC3-azide		Azide
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .

HY-139343

Pomalidomide 4'-alkylC2-azide		Azide
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .

HY-163647

Lenalidomide-COCH-PEG2-azido		Azide
Lenalidomide-COCH-PEG2-azido is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based cereblon ligand and a linker. Lenalidomide-COCH-PEG2-azido can be used in the synthesis of PROTAC AKR1C3 degrader-1 (HY-163609) .

HY-140055

Thalidomide-PEG4-Propargyl		Alkynes
Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology . Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-141015

Pomalidomide-PEG4-azide		Azide
Pomalidomide-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-132208

Pomalidomide 4'-PEG2-azide		Azide
Pomalidomide 4'-PEG2-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology . Pomalidomide 4'-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140844

Thalidomide-O-PEG4-azide		Azide
Thalidomide-O-PEG4-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. Thalidomide-O-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137538

Pomalidomide-PEG3-azide		Azide
Pomalidomide-PEG3-azide is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology . Pomalidomide-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-137537

Pomalidomide-PEG2-azide		Azide
Pomalidomide-PEG2-azide is a synthesized *E3 ligase* ligand-linker conjugate** that incorporates the Pomalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology . Pomalidomide-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-161131

Lenalidomide 4'-alkyl-C3-azide		Azide
Lenalidomide 4'-alkyl-C3-azide (compound 4a) is a click chemical modified Lenalidomide (HY-A0003) that can be used to synthesize PROTACs. Lenalidomide is an orally active immunomodulator and a ligand for the ubiquitin E3 ligase cereblon (CRBN). Lenalidomide 4'-alkyl-C3-azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition reactions (SPAAC) can also occur with molecules containing DBCO or BCN groups .

HY-133139

Lenalidomide-PEG1-azide		Azide
Lenalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Lenalidomide-PEG1-azide incorporates the Lenalidomide based cereblon ligand and a linker.?Lenalidomide-PEG1-azide?can be used to design a PROTAC BRD4 Degrader-2 (HY-133136) . Lenalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-133138

Pomalidomide-PEG1-azide		Azide
Pomalidomide-PEG1-azide is a E3 ligase lgand-linker conjugate. Pomalidomide-PEG1-azide incorporates the Pomalidomide based cereblon ligand and a linker.?Pomalidomide-PEG1-azide?can be used to design a?PROTAC BRD4 Degrader-1 (HY-133131) . Pomalidomide-PEG1-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-130652

Pomalidomide 4'-PEG3-azide		Azide
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach . Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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