2. Gene
  3. ACHE - acetylcholinesterase Gene

ACHE - acetylcholinesterase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 83817 | Gene type: protein coding

About ACHE

Primary_assembly 12: 19,407,360-19,413,651 reverse strand.mRatBN7.2:CM026985.1

This gene has 2 transcripts (splice variants), 234 orthologues, 27 paralogues and is associated with 38 phenotypes. Biased expression in Muscle (RPKM 131.4), Brain (RPKM 122.4) and 7 other tissues.

Summary

Enables acetylcholine binding activity; acetylcholinesterase activity; and choline binding activity. Involved in several processes, including acetylcholine catabolic process; positive regulation of neurogenesis; and response to Insulin. Located in several cellular components, including endoplasmic reticulum; neuronal cell body; and synaptic membrane. Is active in neuromuscular junction and synaptic cleft. Biomarker of acute stress disorder and leptospirosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human AChE (acetylcholinesterase (Cartwright blood group)). [provided by Alliance of Genome Resources, Apr 2022]

ACHE Products(1)

mRNA Protein Name
NM_172009.2 NP_742006.2 acetylcholinesterase precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acetylcholine binding IDA
IDA: Inferred from direct assay
126256 RGD
enables acetylcholinesterase activity IDA
IDA: Inferred from direct assay
126256 RGD
enables choline binding IDA
IDA: Inferred from direct assay
1133098 RGD
Biological Process GO Annotation Evidence Reference Source
involved in acetylcholine catabolic process IDA
IDA: Inferred from direct assay
126256 RGD
involved in acetylcholine metabolic process IMP
IMP: Inferred from mutant phenotype
16628397 RGD
involved in brain development IEP
IEP: Inferred from expression pattern
20147288 RGD
involved in choline metabolic process IDA
IDA: Inferred from direct assay
1133098 RGD
involved in choline metabolic process IMP
IMP: Inferred from mutant phenotype
16628397 RGD
involved in positive regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
12799140 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
12799140 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
27491636 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
8293290 RGD
involved in response to insecticide IEP
IEP: Inferred from expression pattern
7537966 RGD
involved in response to insulin IDA
IDA: Inferred from direct assay
19347982 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
20309727 RGD
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
12799140 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
1133098 RGD
located in cell surface IDA
IDA: Inferred from direct assay
2731551 RGD
located in dendrite IDA
IDA: Inferred from direct assay
1133098 RGD
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
1133098 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
20147288 RGD
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
26820598 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
1133098 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
1133098 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16052514 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
3655326 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
3655326 RGD
is active in synaptic cleft IDA
IDA: Inferred from direct assay
26820598 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACHE Protein Structure

COesterase

COesterase: pfam00135 (36 - 562)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 616 a.a.
Protein Preferred Names Protein Names

acetylcholinesterase

glycolipid-anchored form of acetylcholinesterase

Related Agents

Approval
Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0034 Donepezil Hydrochloride Inhibitor 99.92% Yes
HY-14566 Donepezil Inhibitor 99.87% Yes
HY-76299 Galanthamine Inhibitor 99.96% Yes
HY-17368 Rivastigmine Inhibitor 99.93% Yes
HY-B1266 Physostigmine salicylate Inhibitor 99.37% Unkown
HY-17387 (-)-Huperzine A Inhibitor 99.74% Yes
HY-11017 Rivastigmine tartrate Inhibitor 99.03% Yes
HY-111338 Tacrine Inhibitor 99.91% Yes
HY-B0207A Pyridostigmine bromide Inhibitor 99.93% Yes
HY-B1488 Tacrine hydrochloride Inhibitor 99.95% Unkown
HY-107922 Ethopropazine hydrochloride Inhibitor 99.66% Unkown
HY-B0732 Itopride hydrochloride Inhibitor 99.85% Unkown
HY-B2244 Tacrine hydrochloride (hydrate) Inhibitor 99.98% Unkown
HY-A0009 Galanthamine hydrobromide Inhibitor 99.93% Yes
HY-B1200 Pralidoxime chloride Activator 99.73% Unkown
HY-B1738A Pralidoxime iodide Activator ≥98.0% Unkown
HY-100919 Ambenonium chloride Inhibitor 96.18% Yes
HY-B2155 Acotiamide monohydrochloride trihydrate Inhibitor 99.49% Yes
HY-B1738 Pralidoxime Activator / Unkown
HY-B0949A Protriptyline Inhibitor / Unkown
HY-B0732A Itopride Antagonist / Unkown
HY-114899 Azamethiphos Inhibitor 96.46% Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-N2320 Physostigmine hemisulfate Inhibitor ≥99.0% Phase 4
HY-103374 Phenserine Inhibitor 99.55% Phase 3
HY-19651 Zanapezil free base Inhibitor 99.23% Phase 3
HY-127165 Velnacrine Inhibitor / Phase 3
HY-10399A Ladostigil hydrochloride Inhibitor 99.94% Phase 2
Pre-clinical Phase
Bioactive Molecules (214)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108477 TMPyP4 tosylate Inhibitor ≥98.0% Unkown
HY-138097 α-NETA Inhibitor ≥98.0% Unkown
HY-107569 Garcinol Inhibitor ≥99.0% Unkown
HY-N0285 Imperatorin Inhibitor 98.72% Unkown
HY-N0342 Scopoletin Inhibitor 99.89% Unkown
HY-N0528 Linarin Inhibitor 98.00% Unkown
HY-16009 Buntanetap Inhibitor 99.71% Unkown
HY-N0226A Epiberberine chloride Inhibitor 99.02% Unkown
HY-N0286 Isoimperatorin Inhibitor 99.61% Unkown
HY-N5077 Sinapine Inhibitor 99.96% Unkown
HY-N0810 Timosaponin AIII 99.73% Unkown
HY-B0815 Chlorpyrifos Inhibitor 99.94% Unkown
HY-N0826 Corynoline Inhibitor 99.12% Unkown
HY-N0923 Corydaline Inhibitor 99.70% Unkown
HY-N0740 Jatrorrhizine chloride Inhibitor 99.88% Unkown
HY-N0450 Sinapine thiocyanate Inhibitor 99.74% Unkown
HY-B0832 Profenofos Inhibitor 96.07% Unkown
HY-N0825 Nodakenin Inhibitor 98.76% Unkown
HY-N2425 Rhodiosin Inhibitor 99.36% Unkown
HY-B0841 Acephate Inhibitor ≥98.0% Unkown
HY-75247 Coumaran Inhibitor 99.54% Unkown
HY-N4142 Cyanidin-3-O-galactoside chloride Inhibitor 99.20% Unkown
HY-W017423 (-)-Carvone Inhibitor 99.91% Unkown
HY-N2230 N-p-trans-Coumaroyltyramine Inhibitor 98.78% Unkown
HY-N0702 Tenuifolin Inhibitor 99.24% Unkown
HY-N0241 Rhodionin Inhibitor 98.78% Unkown
HY-100620 RPR121056 Inhibitor 99.59% Unkown
HY-N6805 Isoeugenol acetate Inhibitor 99.92% Unkown
HY-W014700 Glycyl-L-glutamic acid Modulator ≥95.0% Unkown
HY-17388 (±)-Huperzine A Inhibitor 98.73% Unkown
HY-124957 β-NETA Inhibitor ≥98.0% Unkown
HY-122203 PCS1055 dihydrochloride Inhibitor 98.88% Unkown
HY-P2616A Mca-YVADAP-Lys(Dnp)-OH TFA Chemical 98.85% Unkown
HY-135761 Penconazole Inhibitor 98.91% Unkown
HY-N1474 Picfeltarraenin IA Inhibitor 99.83% Unkown
HY-B1093 Fenchlorphos Inhibitor 99.87% Unkown
HY-103373 PE154 Inhibitor 99.01% Unkown
HY-I0020 Galanthaminone Inhibitor 99.63% Unkown
HY-N2211 Picfeltarraenin IB Inhibitor 98.53% Unkown
HY-N0801 Polygalacic acid Inhibitor 98.92% Unkown
HY-155140 BChE-IN-17 Inhibitor 99.07% Unkown
HY-N6895 Violanthin Inhibitor 95.14% Unkown
HY-B1881 Pirimiphos-methyl Inhibitor 98.00% Unkown
HY-N7993 Manghaslin Inhibitor ≥98.0% Unkown
HY-118165 Phenthoate Inhibitor 98.71% Unkown
HY-W795027 Anatoxin-a Inhibitor / Unkown
HY-N7263 Galanthamine N-Oxide Inhibitor 99.90% Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.15% Unkown
HY-122203A PCS1055 Inhibitor 98.02% Unkown
HY-149212 SD-6 Inhibitor ≥98.0% Unkown
HY-119419 Pirimicarb Inhibitor 99.50% Unkown
HY-N4191 Isorosmanol Inhibitor 98.08% Unkown
HY-19651B Zanapezil fumarate Inhibitor 99.63% Unkown
HY-N5120 Dihydrowithaferin A Inhibitor ≥99.0% Unkown
HY-151368 AChE/BChE-IN-10 Inhibitor 99.67% Unkown
HY-164130 AChE-IN-65 Inhibitor / Unkown
HY-N0226 Epiberberine Inhibitor 98.46% Unkown
HY-N2176A (±)-Marmesin ≥95.0% Unkown
HY-115910A Y13g dihydrochloride Inhibitor 99.89% Unkown
HY-105327 P11149 Inhibitor 99.23% Unkown
HY-121072 ASS234 Inhibitor 99.6% Unkown
HY-107275 Ebeiedinone Inhibitor 99.51% Unkown
HY-N2192 Swertianolin Inhibitor 99.54% Unkown
HY-19651A Zanapezil Inhibitor 99.63% Unkown
HY-110389 Pitofenone hydrochloride Inhibitor 99.88% Unkown
HY-126765 Territrem B Inhibitor ≥95.0% Unkown
HY-131971 AChE/BChE-IN-1 Inhibitor / Unkown
HY-151436 ZLMT-12 Inhibitor / Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-168052 hAChE-IN-9 Inhibitor / Unkown
HY-N10701 AChE/BChE-IN-11 Inhibitor / Unkown
HY-151562 AChE/BuChE/MAO-B-IN-1 Inhibitor / Unkown
HY-108048A Desoxypeganine hydrochloride Inhibitor / Unkown
HY-152111 AChE/MAO-B-IN-3 Inhibitor / Unkown
HY-170560 AChE/hCA I-IN-1 Inhibitor / Unkown
HY-161842 AChE-IN-67 Inhibitor / Unkown
HY-101653 MHP 133 Inhibitor / Unkown
HY-169962 hCA I-IN-4 Inhibitor / Unkown
HY-149300 SB-1436 Inhibitor / Unkown
HY-144388 ChE/Aβ1-42-IN-1 Inhibitor / Unkown
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / Unkown
HY-151885 Dual AChE-MAO B-IN-3 Inhibitor / Unkown
HY-158092 ChEs/MAOs-IN-2 Inhibitor / Unkown
HY-159081 AChE/BChE-IN-20 Inhibitor / Unkown
HY-B0830S Isoprocarb-d3 Inhibitor / Unkown
HY-N10781 Isograndifoliol Inhibitor / Unkown
HY-162915 AChE-IN-75 Inhibitor / Unkown
HY-163909 AChE-IN-72 Inhibitor / Unkown
HY-143252 CEase-IN-1 Inhibitor / Unkown
HY-144775 AChE-IN-10 Inhibitor / Unkown
HY-N2898 Artanin Inhibitor / Unkown
HY-170417 hAChE/hBuChE/GSK-3β-IN-1 Inhibitor / Unkown
HY-108048 Desoxypeganine Inhibitor / Unkown
HY-151927 AChE-IN-28 Inhibitor / Unkown
HY-114803 Kokusaginine Inhibitor / Unkown
HY-144389 hAChE/Aβ1-42-IN-1 Inhibitor / Unkown
HY-162639 α-Glucosidase-IN-68 Inhibitor / Unkown
HY-157532 AChE-IN-55 Inhibitor / Unkown
HY-145235 AChE-IN-4 / Unkown
HY-146959 K203 Activator / Unkown
HY-132904 eeAChE-IN-2 Inhibitor / Unkown
HY-132903 eeAChE-IN-1 Inhibitor / Unkown
HY-115910 Y13g Inhibitor / Unkown
HY-146315 AChE/BChE-IN-6 Inhibitor / Unkown
HY-149233 hAChE-IN-1 Inhibitor / Unkown
HY-149287 hAChE/hBACE-1-IN-1 Inhibitor / Unkown
HY-159116 AChE-IN-69 Inhibitor / Unkown
HY-152109 AChE/MAO-IN-1 Inhibitor / Unkown
HY-162681 eeAChE-IN-3 Inhibitor / Unkown
HY-115919 AChE-IN-8 Inhibitor / Unkown
HY-156372 AChE-IN-44 Inhibitor / Unkown
HY-147846 AChE/PDE4-IN-1 Inhibitor / Unkown
HY-N12581 Kuwanon U Inhibitor / Unkown
HY-163514 hAChE-IN-8 Inhibitor / Unkown
HY-157087 AChE/MAO-B-IN-4 Inhibitor / Unkown
HY-123887 Manumycin B Inhibitor / Unkown
HY-B0830 Isoprocarb Inhibitor / Unkown
HY-163537 AChE/BuChE-IN-5 Inhibitor / Unkown
HY-168241 Flucopride Inhibitor / Unkown
HY-155713 AChE-IN-34 Inhibitor / Unkown
HY-162933 AChE-IN-77 Inhibitor / Unkown
HY-W130236 Methylene Violet 3RAX Inhibitor / Unkown
HY-159482 SBN-284 Inhibitor / Unkown
HY-149288 hAChE/hBACE-1-IN-2 Inhibitor / Unkown
HY-159880 AChE/BChE-IN-24 Inhibitor / Unkown
HY-105853 Pitofenone Inhibitor / Unkown
HY-169162 hBChE-IN-3 Inhibitor / Unkown
HY-157296 AChE-IN-47 Inhibitor / Unkown
HY-162591 MR33317 Inhibitor / Unkown
HY-144762 K027 Inhibitor / Unkown
HY-147952 AChE-IN-20 Inhibitor / Unkown
HY-N12423 Bis-(-)-8-demethylmaritidine Inhibitor / Unkown
HY-147938 AChE-IN-19 Inhibitor / Unkown
HY-N10917 Xanthohumol I Inhibitor / Unkown
HY-169961 BChE-IN-38 Inhibitor / Unkown
HY-148412 Monarsen Inhibitor / Unkown
HY-146663A AChE/BChE-IN-3 hydrochloride Inhibitor / Unkown
HY-149273 hBChE-IN-1 Inhibitor / Unkown
HY-122080 Memoquin Inhibitor / Unkown
HY-169163 BChE-IN-36 Inhibitor / Unkown
HY-I1111S2 Fmoc-L-Val-OH-13C5,15N Inhibitor ≥98% Unkown
HY-146762 MAO-B-IN-7 Inhibitor / Unkown
HY-170561 AChE/BuChE-IN-6 Inhibitor / Unkown
HY-161512 hAChE/hBACE-1-IN-4 Inhibitor / Unkown
HY-157978 AChE-IN-59 Inhibitor / Unkown
HY-127087 Isogarcinol Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-150545 AChE-IN-21 Inhibitor / Unkown
HY-149090 AChE/BuChE/MAO-B-IN-2 / Unkown
HY-149211 AChE/BChE-IN-12 Inhibitor / Unkown
HY-155366 hAChE-IN-6 Inhibitor / Unkown
HY-144272 AChE-IN-5 Inhibitor / Unkown
HY-152232 BChE-IN-15 Inhibitor / Unkown
HY-N12388 AChE-IN-46 Inhibitor / Unkown
HY-163441 BChE-IN-31 Inhibitor / Unkown
HY-N11641 Methyl ganoderate A acetonide Inhibitor / Unkown
HY-149237 hAChE-IN-2 Inhibitor / Unkown
HY-155714 AChE-IN-35 Inhibitor / Unkown
HY-157382 AChE-IN-51 Inhibitor / Unkown
HY-168603 AChE/CA I-IN-1 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-N10488 BChE-IN-11 Inhibitor / Unkown
HY-161508 AChE/BChE-IN-19 Inhibitor / Unkown
HY-151152 AChE-IN-24 Inhibitor / Unkown
HY-158261 AChE-IN-63 Inhibitor / Unkown
HY-155284 K1833 Inhibitor / Unkown
HY-170389 BChE-IN-39 Inhibitor / Unkown
HY-150728 AChE-IN-22 Inhibitor / Unkown
HY-161156 BChE-IN-26 Inhibitor / Unkown
HY-161507 hCAI/II-IN-8 Inhibitor / Unkown
HY-162693 AChE-IN-68 Inhibitor / Unkown
HY-168731 AChE/BChE-IN-25 Inhibitor / Unkown
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / Unkown
HY-149272 tau/Aβ40 aggregation-IN-1 Inhibitor / Unkown
HY-162036 α-Amylase/α-Glucosidase-IN-7 Inhibitor / Unkown
HY-158978 Multitarget AD inhibitor-2 Inhibitor / Unkown
HY-49373 AChE-IN-64 Inhibitor / Unkown
HY-N8547A (Rac)-Sclerone Inhibitor / Unkown
HY-118222 KBR 2822 Inhibitor / Unkown
HY-163126 AChE-IN-52 Inhibitor / Unkown
HY-155085 hAChE-IN-3 Inhibitor / Unkown
HY-162812 H3R antagonist 4 Inhibitor / Unkown
HY-170583 hAChE-IN-10 Inhibitor / Unkown
HY-143291 AChE-IN-9 Inhibitor / Unkown
HY-158695 Dual AChE-MAO B-IN-4 Inhibitor / Unkown
HY-157981 AChE-IN-60 Inhibitor / Unkown
HY-159898 AChE/BChE-IN-23 Inhibitor / Unkown
HY-151260 AChE/BACE1/GSK3β-IN-1 Inhibitor / Unkown
HY-162338 BChE-IN-29 Inhibitor / Unkown
HY-162606 MAO-A/B-IN-3 Inhibitor / Unkown
HY-152110 AChE/MAO-IN-2 Inhibitor / Unkown
HY-115973 AChE-IN-11 Inhibitor / Unkown
HY-N10384 AChE-IN-17 Inhibitor / Unkown
HY-134006 Stemoninine Inhibitor / Unkown
HY-143465 BChE-IN-5 Inhibitor / Unkown
HY-157982 BChE-IN-28 Inhibitor / Unkown
HY-161142 Carbonic anhydrase/AChE-IN-1 Inhibitor / Unkown
HY-161311 AChE/BChE-IN-18 Inhibitor / Unkown
HY-161150 AChE/BChE-IN-17 Inhibitor / Unkown
HY-161243 AChE-IN-56 Inhibitor / Unkown
HY-147939 AChE/BuChE-IN-3 Inhibitor / Unkown
HY-149087 MR2938 Inhibitor / Unkown
HY-157441 AChE/Aβ-IN-4 Inhibitor / Unkown
HY-N2219 Picfeltarraegenin X Inhibitor / Unkown
HY-157440 AChE/Aβ-IN-3 Inhibitor / Unkown
HY-W130025 p-Xylene bis(pyridinium bromide) Inhibitor / Unkown
HY-18039 WAY-361789 Agonist / Unkown
HY-N2971 Buxbodine B Inhibitor / Unkown
HY-N7346 Lucidadiol Inhibitor / Unkown
HY-134137 Donepezil N-oxide Inhibitor / Unkown
HY-W049312 7-Methoxytacrine Inhibitor / Unkown
HY-161029 T14-A24 Inhibitor / Unkown
HY-169173 AL284 Inhibitor / Unkown
HY-115650 TAE-1 Inhibitor 96.17% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ACHE NCBI NCBI:43
Canis familiaris ACHE NCBI NCBI:489828
Macaca fascicularis ACHE NCBI NCBI:102143626
Mus musculus ACHE NCBI NCBI:11423
Susscrofa domestica ACHE NCBI
Leporidae ACHE NCBI
Macaca mulatta ACHE NCBI NCBI:713370