2. Gene
  3. Ache - acetylcholinesterase Gene

Ache - acetylcholinesterase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 11423 | Gene type: protein coding

About Ache

Chromosome 5: 137,285,781-137,292,728 forward strand.GRCm39:CM000998.3

This gene has 9 transcripts (splice variants), 234 orthologues, 25 paralogues and is associated with 50 phenotypes. Broad expression in cerebellum adult (RPKM 25.6), thymus adult (RPKM 23.5) and 19 other tissues.

Summary

Enables several functions, including acetylcholinesterase activity; identical protein binding activity; and protein self-association. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including acetylcholine catabolic process; acetylcholine receptor signaling pathway; and regulation of receptor recycling. Located in several cellular components, including basement membrane; cell surface; and neuromuscular junction. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human AChE (acetylcholinesterase (Cartwright blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Ache Products(2)

mRNA Protein Name
NM_009599.4 NP_033729.1 acetylcholinesterase precursor
NM_001290010.1 NP_001276939.1 acetylcholinesterase precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables acetylcholinesterase activity IDA
IDA: Inferred from direct assay
7512968 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
8626792 MGI
enables laminin binding IPI
IPI: Inferred from physical interaction
15474030 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20053883 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within acetylcholine catabolic process IDA
IDA: Inferred from direct assay
7512968 MGI
acts upstream of or within acetylcholine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
14645660 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
17038428 MGI
acts upstream of or within receptor internalization IMP
IMP: Inferred from mutant phenotype
14645660 MGI
acts upstream of or within regulation of receptor recycling IMP
IMP: Inferred from mutant phenotype
14645660 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
15579149 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basement membrane IDA
IDA: Inferred from direct assay
7885444 MGI
located in cell surface IDA
IDA: Inferred from direct assay
16434405 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
8626792 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
7885444 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
8626792 MGI
located in synapse IDA
IDA: Inferred from direct assay
10995443 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ache Protein Structure

COesterase

COesterase: pfam00135 (36 - 562)

AChE_tetra

AChE_tetra: pfam08674 (577 - 610)

  • 0
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  • 400
  • 500
  • 614 a.a.
Protein Preferred Names Protein Names

acetylcholinesterase

Recombinant Ache Proteins

Cat. No. Product Name Accession Purity
HY-P72811 Acetylcholinesterase/ACHE Protein, Mouse (HEK293, His) P21836-1/NP_033729.1 (E32-L614) ≥95%

Related Agents

Approval
Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0034 Donepezil Hydrochloride Inhibitor 99.92% Yes
HY-14566 Donepezil Inhibitor 99.91% Yes
HY-76299 Galanthamine Inhibitor 99.96% Yes
HY-17368 Rivastigmine Inhibitor 99.93% Yes
HY-B1266 Physostigmine salicylate Inhibitor 99.37% Unkown
HY-17387 (-)-Huperzine A Inhibitor 99.74% Yes
HY-B0207A Pyridostigmine bromide Inhibitor 99.93% Yes
HY-111338 Tacrine Inhibitor 99.91% Yes
HY-11017 Rivastigmine tartrate Inhibitor 99.71% Yes
HY-B1488 Tacrine hydrochloride Inhibitor 99.95% Unkown
HY-107922 Ethopropazine hydrochloride Inhibitor 99.66% Unkown
HY-B2244 Tacrine hydrochloride (hydrate) Inhibitor 99.98% Unkown
HY-B0732 Itopride hydrochloride Inhibitor 99.85% Unkown
HY-A0009 Galanthamine hydrobromide Inhibitor 99.93% Yes
HY-B1200 Pralidoxime chloride Activator 99.73% Unkown
HY-B1738A Pralidoxime iodide Activator ≥98.0% Unkown
HY-100919 Ambenonium chloride Inhibitor 95.01% Yes
HY-B2155 Acotiamide monohydrochloride trihydrate Inhibitor 99.49% Yes
HY-B1738 Pralidoxime Activator / Unkown
HY-114899 Azamethiphos Inhibitor 96.46% Unkown
HY-B0732A Itopride Antagonist / Unkown
HY-B0949A Protriptyline Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-N2320 Physostigmine hemisulfate Inhibitor ≥99.0% Phase 4
HY-103374 Phenserine Inhibitor 99.55% Phase 3
HY-19651 Zanapezil free base Inhibitor 99.23% Phase 3
HY-127165 Velnacrine Inhibitor / Phase 3
HY-10399A Ladostigil hydrochloride Inhibitor 99.94% Phase 2
Pre-clinical Phase
Bioactive Molecules (201)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108477 TMPyP4 tosylate Inhibitor ≥98.0% Unkown
HY-138097 α-NETA Inhibitor ≥98.0% Unkown
HY-107569 Garcinol Inhibitor ≥99.0% Unkown
HY-N0285 Imperatorin Inhibitor 98.72% Unkown
HY-N0342 Scopoletin Inhibitor 99.89% Unkown
HY-N0528 Linarin Inhibitor 98.00% Unkown
HY-16009 Buntanetap Inhibitor 99.71% Unkown
HY-N0286 Isoimperatorin Inhibitor 99.61% Unkown
HY-N0226A Epiberberine chloride Inhibitor 99.02% Unkown
HY-N5077 Sinapine Inhibitor 99.96% Unkown
HY-N0810 Timosaponin AIII 99.73% Unkown
HY-B0815 Chlorpyrifos Inhibitor 99.88% Unkown
HY-N0826 Corynoline Inhibitor 99.12% Unkown
HY-N0740 Jatrorrhizine chloride Inhibitor 99.88% Unkown
HY-N0450 Sinapine thiocyanate Inhibitor 99.74% Unkown
HY-N0923 Corydaline Inhibitor 99.70% Unkown
HY-B0832 Profenofos Inhibitor 96.07% Unkown
HY-N0825 Nodakenin Inhibitor 98.76% Unkown
HY-N4142 Cyanidin-3-O-galactoside chloride Inhibitor 99.20% Unkown
HY-N2425 Rhodiosin Inhibitor 99.36% Unkown
HY-75247 Coumaran Inhibitor 99.54% Unkown
HY-B0841 Acephate Inhibitor ≥98.0% Unkown
HY-N2230 N-p-trans-Coumaroyltyramine Inhibitor 98.78% Unkown
HY-W017423 (-)-Carvone Inhibitor 99.55% Unkown
HY-N0702 Tenuifolin Inhibitor 99.24% Unkown
HY-100620 RPR121056 Inhibitor 99.59% Unkown
HY-N6805 Isoeugenol acetate Inhibitor 99.92% Unkown
HY-N0241 Rhodionin Inhibitor 98.78% Unkown
HY-122203 PCS1055 dihydrochloride Inhibitor 98.88% Unkown
HY-124957 β-NETA Inhibitor ≥98.0% Unkown
HY-W014700 Glycyl-L-glutamic acid Modulator ≥95.0% Unkown
HY-P2616A Mca-YVADAP-Lys(Dnp)-OH TFA Chemical 98.85% Unkown
HY-135761 Penconazole Inhibitor 98.91% Unkown
HY-B1881 Pirimiphos-methyl Inhibitor 98.00% Unkown
HY-N1474 Picfeltarraenin IA Inhibitor 99.83% Unkown
HY-17388 (±)-Huperzine A Inhibitor 98.73% Unkown
HY-B1093 Fenchlorphos Inhibitor 99.87% Unkown
HY-155140 BChE-IN-17 Inhibitor 99.07% Unkown
HY-103373 PE154 Inhibitor 99.01% Unkown
HY-N0801 Polygalacic acid Inhibitor 98.92% Unkown
HY-N6895 Violanthin Inhibitor 95.14% Unkown
HY-N2211 Picfeltarraenin IB Inhibitor 98.53% Unkown
HY-118165 Phenthoate Inhibitor 98.71% Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.15% Unkown
HY-151368 AChE/BChE-IN-10 Inhibitor 99.67% Unkown
HY-164130 AChE-IN-65 Inhibitor / Unkown
HY-N0226 Epiberberine Inhibitor 98.46% Unkown
HY-N7263 Galanthamine N-Oxide Inhibitor 99.90% Unkown
HY-115910A Y13g dihydrochloride Inhibitor 99.89% Unkown
HY-126765 Territrem B Inhibitor ≥95.0% Unkown
HY-121072 ASS234 Inhibitor 99.6% Unkown
HY-19651B Zanapezil fumarate Inhibitor 99.63% Unkown
HY-N2192 Swertianolin Inhibitor 99.54% Unkown
HY-N2176A (±)-Marmesin ≥95.0% Unkown
HY-W795027 Anatoxin-a Inhibitor / Unkown
HY-19651A Zanapezil Inhibitor 99.63% Unkown
HY-105327 P11149 Inhibitor 99.23% Unkown
HY-N4191 Isorosmanol Inhibitor 98.08% Unkown
HY-122203A PCS1055 Inhibitor 98.02% Unkown
HY-107275 Ebeiedinone Inhibitor 99.51% Unkown
HY-149212 SD-6 Inhibitor / Unkown
HY-119419 Pirimicarb Inhibitor 99.50% Unkown
HY-N5120 Dihydrowithaferin A Inhibitor ≥99.0% Unkown
HY-110389 Pitofenone hydrochloride Inhibitor 99.88% Unkown
HY-N7993 Manghaslin Inhibitor ≥98.0% Unkown
HY-146678 HDAC6-IN-5 Inhibitor / Unkown
HY-131971 AChE/BChE-IN-1 Inhibitor / Unkown
HY-151436 ZLMT-12 Inhibitor / Unkown
HY-N11641 Methyl ganoderate A acetonide Inhibitor / Unkown
HY-162639 α-Glucosidase-IN-68 Inhibitor / Unkown
HY-168052 hAChE-IN-9 Inhibitor / Unkown
HY-144272 AChE-IN-5 Inhibitor / Unkown
HY-161243 AChE-IN-56 Inhibitor / Unkown
HY-108048A Desoxypeganine hydrochloride Inhibitor / Unkown
HY-162591 MR33317 Inhibitor / Unkown
HY-157440 AChE/Aβ-IN-3 Inhibitor / Unkown
HY-N10488 BChE-IN-11 Inhibitor / Unkown
HY-161508 AChE/BChE-IN-19 Inhibitor / Unkown
HY-149300 SB-1436 Inhibitor / Unkown
HY-N12423 Bis-(-)-8-demethylmaritidine Inhibitor / Unkown
HY-162933 AChE-IN-77 Inhibitor / Unkown
HY-158261 AChE-IN-63 Inhibitor / Unkown
HY-146315 AChE/BChE-IN-6 Inhibitor / Unkown
HY-158092 ChEs/MAOs-IN-2 Inhibitor / Unkown
HY-159898 AChE/BChE-IN-23 Inhibitor / Unkown
HY-162693 AChE-IN-68 Inhibitor / Unkown
HY-162681 eeAChE-IN-3 Inhibitor / Unkown
HY-163909 AChE-IN-72 Inhibitor / Unkown
HY-147938 AChE-IN-19 Inhibitor / Unkown
HY-161507 hCAI/II-IN-8 Inhibitor / Unkown
HY-151927 AChE-IN-28 Inhibitor / Unkown
HY-N10384 AChE-IN-17 Inhibitor / Unkown
HY-162036 α-Amylase/α-Glucosidase-IN-7 Inhibitor / Unkown
HY-163514 hAChE-IN-8 Inhibitor / Unkown
HY-161512 hAChE/hBACE-1-IN-4 Inhibitor / Unkown
HY-N8547A (Rac)-Sclerone Inhibitor / Unkown
HY-146959 K203 Activator / Unkown
HY-149237 hAChE-IN-2 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-155085 hAChE-IN-3 Inhibitor / Unkown
HY-143465 BChE-IN-5 Inhibitor / Unkown
HY-115910 Y13g Inhibitor / Unkown
HY-108048 Desoxypeganine Inhibitor / Unkown
HY-158695 Dual AChE-MAO B-IN-4 Inhibitor / Unkown
HY-159880 AChE/BChE-IN-24 Inhibitor / Unkown
HY-156372 AChE-IN-44 Inhibitor / Unkown
HY-150728 AChE-IN-22 Inhibitor / Unkown
HY-152110 AChE/MAO-IN-2 Inhibitor / Unkown
HY-115973 AChE-IN-11 Inhibitor / Unkown
HY-N12581 Kuwanon U Inhibitor / Unkown
HY-155284 K1833 Inhibitor / Unkown
HY-157982 BChE-IN-28 Inhibitor / Unkown
HY-148412 Monarsen Inhibitor / Unkown
HY-N12388 AChE-IN-46 Inhibitor / Unkown
HY-158334 NDs-IN-1 Inhibitor / Unkown
HY-157441 AChE/Aβ-IN-4 Inhibitor / Unkown
HY-167833 Suillin Inhibitor / Unkown
HY-163537 AChE/BuChE-IN-5 Inhibitor / Unkown
HY-158978 Multitarget AD inhibitor-2 Inhibitor / Unkown
HY-161150 AChE/BChE-IN-17 Inhibitor / Unkown
HY-159482 SBN-284 Inhibitor / Unkown
HY-101653 MHP 133 Inhibitor / Unkown
HY-163441 BChE-IN-31 Inhibitor / Unkown
HY-150545 AChE-IN-21 Inhibitor / Unkown
HY-W130236 Methylene Violet 3RAX Inhibitor / Unkown
HY-162812 H3R antagonist 4 Inhibitor / Unkown
HY-N10701 AChE/BChE-IN-11 Inhibitor / Unkown
HY-143291 AChE-IN-9 Inhibitor / Unkown
HY-N10917 Xanthohumol I Inhibitor / Unkown
HY-115919 AChE-IN-8 Inhibitor / Unkown
HY-B0830S Isoprocarb-d3 Inhibitor / Unkown
HY-N10781 Isograndifoliol Inhibitor / Unkown
HY-144762 K027 Inhibitor / Unkown
HY-144388 ChE/Aβ1-42-IN-1 Inhibitor / Unkown
HY-157382 AChE-IN-51 Inhibitor / Unkown
HY-149288 hAChE/hBACE-1-IN-2 Inhibitor / Unkown
HY-146663A AChE/BChE-IN-3 hydrochloride Inhibitor / Unkown
HY-169163 BChE-IN-36 Inhibitor / Unkown
HY-159116 AChE-IN-69 Inhibitor / Unkown
HY-157532 AChE-IN-55 Inhibitor / Unkown
HY-161142 Carbonic anhydrase/AChE-IN-1 Inhibitor / Unkown
HY-145235 AChE-IN-4 / Unkown
HY-151152 AChE-IN-24 Inhibitor / Unkown
HY-157978 AChE-IN-59 Inhibitor / Unkown
HY-127087 Isogarcinol Inhibitor / Unkown
HY-N2219 Picfeltarraegenin X Inhibitor / Unkown
HY-146762 MAO-B-IN-7 Inhibitor / Unkown
HY-143252 CEase-IN-1 Inhibitor / Unkown
HY-132903 eeAChE-IN-1 Inhibitor / Unkown
HY-161156 BChE-IN-26 Inhibitor / Unkown
HY-155366 hAChE-IN-6 Inhibitor / Unkown
HY-149272 tau/Aβ40 aggregation-IN-1 Inhibitor / Unkown
HY-152232 BChE-IN-15 Inhibitor / Unkown
HY-152111 AChE/MAO-B-IN-3 Inhibitor / Unkown
HY-B0830 Isoprocarb Inhibitor / Unkown
HY-149233 hAChE-IN-1 Inhibitor / Unkown
HY-49373 AChE-IN-64 Inhibitor / Unkown
HY-155714 AChE-IN-35 Inhibitor / Unkown
HY-144775 AChE-IN-10 Inhibitor / Unkown
HY-163126 AChE-IN-52 Inhibitor / Unkown
HY-162915 AChE-IN-75 Inhibitor / Unkown
HY-144389 hAChE/Aβ1-42-IN-1 Inhibitor / Unkown
HY-147846 AChE/PDE4-IN-1 Inhibitor / Unkown
HY-168241 Flucopride Inhibitor / Unkown
HY-149211 AChE/BChE-IN-12 Inhibitor / Unkown
HY-123887 Manumycin B Inhibitor / Unkown
HY-162606 MAO-A/B-IN-3 Inhibitor / Unkown
HY-132904 eeAChE-IN-2 Inhibitor / Unkown
HY-122080 Memoquin Inhibitor / Unkown
HY-152113 AChE/BChE/MAO-B-IN-3 Inhibitor / Unkown
HY-168603 AChE/CA I-IN-1 Inhibitor / Unkown
HY-155713 AChE-IN-34 Inhibitor / Unkown
HY-147939 AChE/BuChE-IN-3 Inhibitor / Unkown
HY-152109 AChE/MAO-IN-1 Inhibitor / Unkown
HY-151885 Dual AChE-MAO B-IN-3 Inhibitor / Unkown
HY-169162 hBChE-IN-3 Inhibitor / Unkown
HY-I1111S2 Fmoc-L-Val-OH-13C5,15N Inhibitor ≥98% Unkown
HY-157296 AChE-IN-47 Inhibitor / Unkown
HY-149287 hAChE/hBACE-1-IN-1 Inhibitor / Unkown
HY-152112 AChE/BChE/MAO-B-IN-2 Inhibitor / Unkown
HY-147952 AChE-IN-20 Inhibitor / Unkown
HY-151562 AChE/BuChE/MAO-B-IN-1 Inhibitor / Unkown
HY-157981 AChE-IN-60 Inhibitor / Unkown
HY-151260 AChE/BACE1/GSK3β-IN-1 Inhibitor / Unkown
HY-159081 AChE/BChE-IN-20 Inhibitor / Unkown
HY-149273 hBChE-IN-1 Inhibitor / Unkown
HY-161842 AChE-IN-67 Inhibitor / Unkown
HY-134006 Stemoninine Inhibitor / Unkown
HY-157087 AChE/MAO-B-IN-4 Inhibitor / Unkown
HY-149090 AChE/BuChE/MAO-B-IN-2 / Unkown
HY-114803 Kokusaginine Inhibitor / Unkown
HY-161311 AChE/BChE-IN-18 Inhibitor / Unkown
HY-N2898 Artanin Inhibitor / Unkown
HY-162338 BChE-IN-29 Inhibitor / Unkown
HY-149087 MR2938 Inhibitor / Unkown
HY-161029 T14-A24 Inhibitor / Unkown
HY-169173 AL284 Inhibitor / Unkown
HY-18039 WAY-361789 Agonist / Unkown
HY-W049312 7-Methoxytacrine Inhibitor / Unkown
HY-N7346 Lucidadiol Inhibitor / Unkown
HY-115650 TAE-1 Inhibitor 96.17% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ache NCBI NCBI:43
Canis familiaris Ache NCBI NCBI:489828
Macaca fascicularis Ache NCBI NCBI:102143626
Susscrofa domestica Ache NCBI
Leporidae Ache NCBI
Rattus norvegicus Ache NCBI NCBI:83817
Macaca mulatta Ache NCBI NCBI:713370