2. Gene
  3. Ager - advanced glycosylation end product-specific receptor Gene

Ager - advanced glycosylation end product-specific receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as RAGE

Gene ID: 11596 | Gene type: protein coding

About Ager

Summary

Enables S100 protein binding activity; advanced glycation end-product binding activity; and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of long-term synaptic potentiation; and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of advanced glycation end-product receptor activity; and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ager Products(4)

mRNA Protein Name
NM_001271422.1 NP_001258351.1 advanced glycosylation end product-specific receptor isoform b precursor
NM_001271423.1 NP_001258352.1 advanced glycosylation end product-specific receptor isoform c precursor
NM_001271424.1 NP_001258353.1 advanced glycosylation end product-specific receptor isoform d
NM_007425.3 NP_031451.2 advanced glycosylation end product-specific receptor isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables S100 protein binding IPI
IPI: Inferred from physical interaction
18606705 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10399917 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within astrocyte development IMP
IMP: Inferred from mutant phenotype
22577135 MGI
involved in cellular response to amyloid-beta IMP
IMP: Inferred from mutant phenotype
19221410 MGI
acts upstream of or within induction of positive chemotaxis IMP
IMP: Inferred from mutant phenotype
14744997 MGI
acts upstream of or within inflammatory response IGI
IGI: Inferred from genetic interaction
21148126 MGI
involved in microglial cell activation IGI
IGI: Inferred from genetic interaction
22406537 MGI
involved in negative regulation of blood circulation IGI
IGI: Inferred from genetic interaction
12808450 MGI
involved in negative regulation of long-term synaptic potentiation IGI
IGI: Inferred from genetic interaction
18367618 MGI
acts upstream of or within positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
18323529 MGI
involved in positive regulation of chemokine production IGI
IGI: Inferred from genetic interaction
22406537 MGI
involved in positive regulation of endothelin production IGI
IGI: Inferred from genetic interaction
12808450 MGI
involved in positive regulation of interleukin-1 beta production IGI
IGI: Inferred from genetic interaction
22406537 MGI
involved in positive regulation of interleukin-6 production IGI
IGI: Inferred from genetic interaction
22406537 MGI
acts upstream of or within positive regulation of monocyte chemotactic protein-1 production IGI
IGI: Inferred from genetic interaction
24995813 MGI
involved in positive regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
22406537 MGI
acts upstream of or within protein localization to membrane IMP
IMP: Inferred from mutant phenotype
18323529 MGI
acts upstream of or within regulation of DNA binding IMP
IMP: Inferred from mutant phenotype
18323529 MGI
involved in regulation of inflammatory response IDA
IDA: Inferred from direct assay
10399917 MGI
involved in regulation of long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
19221410 MGI
involved in regulation of p38MAPK cascade IGI
IGI: Inferred from genetic interaction
18367618 MGI
involved in response to amyloid-beta IGI
IGI: Inferred from genetic interaction
18367618 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
18323529 MGI
involved in transcytosis IGI
IGI: Inferred from genetic interaction
22406537 MGI
involved in transcytosis IMP
IMP: Inferred from mutant phenotype
12808450 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

advanced glycosylation end product-specific receptor

advanced glycation end-products receptor

receptor for advanced glycosylation end products

Ager Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Ager Q62151 Prkcz Mus musculus Q02956
Anti Bait CoIP
21829704
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Ager Proteins

Cat. No. Product Name Accession Purity
HY-P74425 AGER Protein, Mouse (HEK293, His) Q62151-1/NP_031451.2 (Q24-A342) ≥95%

Related Agents

Approval
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0146 Verteporfin 99.58% Yes
HY-16561 Resveratrol 99.94% Yes
HY-113416 Dehydroepiandrosterone sulfate 99.28% Unkown
HY-B0167A Sodium Salicylate 99.93% Yes
HY-147080 Avacincaptad pegol sodium Inhibitor 98.53% Unkown
HY-109561 Pegaptanib sodium Inhibitor 98.09% Unkown
HY-14892 Gemigliptin Inhibitor / Unkown
HY-B0146R Verteporfin (Standard) / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108801 Aflibercept Inhibitor 97.90% Unkown
HY-P99116 Faricimab Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (32)
Cat. No. Product Name Effect
Purity Phase
HY-I0626 Cytosine 99.99% Phase 4
HY-W013494 L-Carnosine 99.94% Phase 3
HY-106024B Alagebrium chloride Inhibitor 99.93% Phase 3
HY-19720A Emixustat hydrochloride 99.29% Phase 3
HY-B1745 Pyridoxylamine 99.91% Phase 3
HY-19720 Emixustat Inhibitor 98.00% Phase 3
HY-16467 Squalamine lactate Inhibitor 98.27% Phase 3
HY-116098 Anecortave desacetate 98.36% Phase 3
HY-153484 Bevasiranib Inhibitor / Phase 3
HY-153484A Bevasiranib sodium Inhibitor / Phase 3
HY-112499 Menaquinone-7 ≥98.0% Phase 2
HY-128973 Pyropheophorbide-a ≥98.0% Phase 2
HY-P3204 POT-4 Inhibitor 99.64% Phase 2
HY-128850 N-Acetyl-D-mannosamine ≥98.0% Phase 2
HY-10186 TG 100801 Inhibitor 98.61% Phase 2
HY-136788 ALK4290 Inhibitor 99.79% Phase 2
HY-112499R Menaquinone-7 (Standard) / Phase 2
HY-P1930 Risuteganib Inhibitor / Phase 2
HY-P3204A POT-4 TFA Inhibitor / Phase 2
HY-P5285 Lunasin Inhibitor / Phase 2
HY-W250163 NAD+ lithium / Phase 2
HY-10187 TG 100801 Hydrochloride Inhibitor / Phase 2
HY-14564 GTS-21 Agonist / Phase 2
HY-N0088 Apocynin Inhibitor 99.96% Phase 1
HY-136093A Lixumistat acetate Activator 99.88% Phase 1
HY-N0160 Kinetin 99.47% Phase 1
HY-W050154 Kojic acid Inhibitor 99.99% Phase 1
HY-N1420 Rhamnose ≥98.0% Phase 1
HY-15114 S 17092 Inhibitor 98.42% Phase 1
HY-136093 Lixumistat hydrochloride Activator / Phase 1
HY-16387 PF 00337210 Inhibitor / Phase 1
HY-19692 Itasetron Antagonist / Phase 1
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-108801A Aflibercept (VEGF Trap) Inhibitor 97.66% Phase 4
HY-P99298 Lampalizumab Inhibitor 99.46% Phase 3
HY-P99576 Tarcocimab Inhibitor 98.35% Phase 3
HY-P99629 Galegenimab Inhibitor 99.91% Phase 2
Pre-clinical Phase
Bioactive Molecules (176)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131042 NNMTi Inhibitor 99.80% Unkown
HY-N0664 Aucubin Inhibitor 99.49% Unkown
HY-N1485 Cycloastragenol Activator ≥98.0% Unkown
HY-126255 SBI-797812 Activator 99.74% Unkown
HY-N0568 Madecassoside 99.58% Unkown
HY-N0033 Poliumoside Inhibitor 99.80% Unkown
HY-N0295 Protocatechualdehyde Inhibitor 99.98% Unkown
HY-147313 TH10785 Activator 99.93% Unkown
HY-129460 XJB-5-131 Inhibitor 99.9% Unkown
HY-147059 Dieckol 99.81% Unkown
HY-11068 SB 239063 Inhibitor 99.61% Unkown
HY-103157 PD146176 99.16% Unkown
HY-120912 Gingerenone A Activator 99.70% Unkown
HY-150069 UBX1325 99.16% Unkown
HY-129380 Fructosyl-lysine ≥95.0% Unkown
HY-110195 Smurf1-IN-A01 99.81% Unkown
HY-137817 BCH001 Inhibitor 98.83% Unkown
HY-16561R Resveratrol (Standard) 99.73% Unkown
HY-N2292 Kinsenoside 99.91% Unkown
HY-P1928 Humanin Inhibitor 99.83% Unkown
HY-N0012 Glycitin Inhibitor 99.84% Unkown
HY-W013573 S-Allyl-L-cysteine Inducer 98.64% Unkown
HY-402361 TERT activator-1 99.50% Unkown
HY-P1149A Epitalon TFA Activator 99.62% Unkown
HY-N2485 4'-Methoxyresveratrol 99.48% Unkown
HY-P3252A Pegcetacoplan acetate Inhibitor 98.72% Unkown
HY-14892A Gemigliptin tartrate Inhibitor 98.17% Unkown
HY-N5135 Liriopesides B 99.85% Unkown
HY-P1149 Epitalon Activator 99.50% Yes
HY-107811 Harmol 99.77% Unkown
HY-129566 Withanolide B Activator ≥99.0% Unkown
HY-B1745A Pyridoxylamine dihydrochloride 99.95% Unkown
HY-N6818 5,​7,​4'-​Trimethoxyflavone 99.65% Unkown
HY-N7690 3,5,7,3′,4′-Pentamethoxyflavone Inhibitor 99.15% Unkown
HY-106353 Smilagenin Agonist ≥98.0% Yes
HY-113303 FAPy-adenine 99.95% Unkown
HY-128463 N-tert-Butyl-α-phenylnitrone Inhibitor 99.94% Unkown
HY-129380A Fructosyl-lysine dihydrochloride ≥95.0% Unkown
HY-76383 LR-90 Inhibitor 99.59% Unkown
HY-N4089 Quercetin 3-gentiobioside Inhibitor 99.92% Unkown
HY-N6588 3,4,5-Tricaffeoylquinic acid Inhibitor 98.71% Unkown
HY-133968 24-Methylenecholesterol Activator 99.48% Unkown
HY-101528 IDRA 21 Modulator 99.33% Unkown
HY-N1517 Ganoderic acid C2 99.30% Unkown
HY-N4170 Chebulic acid 99.91% Unkown
HY-P5904 Caveolin-1 (82-101) amide (human, mouse, rat) Inhibitor 98.48% Unkown
HY-15289 Ciproxifan maleate Antagonist 99.75% Unkown
HY-B1340 Carbadox Inhibitor ≥98.0% Unkown
HY-N2278 Kushenol A Inhibitor 99.84% Unkown
HY-16561S Resveratrol-d4 ≥99.0% Unkown
HY-B1169 Timonacic ≥98.0% Unkown
HY-N7628 Cassiaside C 99.90% Unkown
HY-156781 Sirtuin-1 inhibitor 1 Inhibitor 98.09% Unkown
HY-110291 A-971432 Agonist ≥99.0% Unkown
HY-147108 Mitochondria degrader-1 Inducer 95.10% Unkown
HY-159062 Goji Extract Activator / Unkown
HY-W286743 Nε-(Carboxymethyl)-L-lysine 99.70% Unkown
HY-114653 SRPIN803 Inhibitor 99.17% Unkown
HY-132126 SPHINX Inhibitor 99.87% Unkown
HY-133859 M084 Inhibitor / Unkown
HY-154847 WM-662 Inhibitor 99.48% Unkown
HY-N3127 Orobol Inhibitor 99.28% Unkown
HY-P0064 Palmitoyl Tetrapeptide-3 Inhibitor 99.20% Unkown
HY-145486 1-Arachidonoyl-sn-glycerol 3-phosphate ammonium / Unkown
HY-N2550A (+)-Coclaurine hydrochloride 99.09% Unkown
HY-N2947 Boeravinone B Inhibitor ≥97.0% Unkown
HY-N9347 Stepharine Inhibitor ≥98.0% Unkown
HY-P2096 Hexapeptide-11 Inhibitor 99.52% Unkown
HY-117924 AUTEN-67 Inducer ≥92.0% Unkown
HY-W013494S L-Carnosine-d4 99.00% Unkown
HY-W337672 H-Pro-Hyp-OH ≥99.0% Unkown
HY-P1930A Risuteganib hydrochloride Inhibitor 98.66% Unkown
HY-11053 S 24795 Agonist 99.66% Unkown
HY-124609 CAD031 Inhibitor 99.39% Unkown
HY-126487A H-Arg-Lys-OH TFA 99.86% Unkown
HY-153917 CRT0063465 Ligand 99.59% Unkown
HY-15492 AG-13958 Inhibitor 99.71% Unkown
HY-163690 HTRA1-IN-1 Inhibitor / Unkown
HY-65008 N-Demethylricinine 99.84% Unkown
HY-I0626S2 Cytosine-d2 99.69% Unkown
HY-N12486A (3S,8R,9R)-Isofalcarintriol / Unkown
HY-N2284 Sophoflavescenol Inhibitor 98.15% Unkown
HY-N3757 (+)-Dihydrorobinetin ≥98.0% Unkown
HY-N7426 3-Deoxyglucosone / Unkown
HY-P10409 SHLP2 99.18% Unkown
HY-Q49697 Sirtuin modulator 3 Modulator 99.32% Unkown
HY-164159 α-Glucosylrutin Inhibitor / Unkown
HY-158821 ISTH0036 / Unkown
HY-158821A ISTH0036 sodium / Unkown
HY-N6818R 5,​7,​4'-​Trimethoxyflavone (Standard) / Unkown
HY-43515 ESI1 / Unkown
HY-107652 AF-DX 384 Antagonist / Unkown
HY-113033A Pentosidine TFA / Unkown
HY-116780A Prothipendyl hydrochloride Inhibitor / Unkown
HY-124223 AF-DX 384 methanesulfonate Antagonist / Unkown
HY-128463S N-tert-Butyl-α-phenylnitrone-d14 / Unkown
HY-133804 Arteanoflavone Inhibitor / Unkown
HY-133968S1 24-Methylenecholesterol-13C / Unkown
HY-136788A ALK4290 dihydrochloride Inhibitor / Unkown
HY-138830A (S,S)-TAK-418 / Unkown
HY-139464 Q134R 99.55% Unkown
HY-142025 Daumone / Unkown
HY-142778 Lp-PLA2-IN-10 / Unkown
HY-14567A Ciproxifan hydrochloride Antagonist / Unkown
HY-148322 Sirtuin modulator 5 Modulator / Unkown
HY-151487 CypD-IN-3 Inhibitor / Unkown
HY-151488 CypD-IN-4 Inhibitor / Unkown
HY-151489 CypE-IN-1 Inhibitor / Unkown
HY-151546 MRS4596 Antagonist / Unkown
HY-151547 MRS4719 Antagonist / Unkown
HY-153183 Lp-PLA2-IN-12 Inhibitor / Unkown
HY-153560 Lp-PLA2-IN-14 Inhibitor / Unkown
HY-15492A AG-13958 (mono(hydrochloride)) Inhibitor / Unkown
HY-155138 GLS1 Inhibitor-7 Inhibitor / Unkown
HY-155988 Sirtuin modulator 6 Modulator / Unkown
HY-156023 Sirtuin modulator 7 Modulator 99.28% Unkown
HY-157421 Nampt activator-4 Modulator / Unkown
HY-159007 BD-AcAc2 / Unkown
HY-161088 Anti-aging agent 1 / Unkown
HY-162269 Nampt activator-5 Activator / Unkown
HY-162515 8-OAc / Unkown
HY-162866 CXM102 Activator / Unkown
HY-162904 BPU17 / Unkown
HY-162968 MRTF-A-IN-1 Inhibitor / Unkown
HY-162969 MRTF-A-IN-2 Inhibitor / Unkown
HY-163403 VEGFR-2-IN-43 Inhibitor / Unkown
HY-16561G Resveratrol (GMP) / Unkown
HY-16561S1 Resveratrol-13C6 / Unkown
HY-167740 Glycerophosphoinositol (lysine) / Unkown
HY-169085 LRAT-IN-1 / Unkown
HY-169204 Mito-fisetin mF3 Inhibitor / Unkown
HY-169265 BRD-K20733377 Inhibitor / Unkown
HY-169266 BRD-K56819078 Inhibitor / Unkown
HY-66018 Palmitoyl tripeptide-5 biTFA / Unkown
HY-B0801AS Fexofenadine-d10 hydrochloride Inhibitor / Unkown
HY-B1340S Carbadox-d3 Inhibitor / Unkown
HY-E70022 D-Mannose isomerase (PsMaSeAF) / Unkown
HY-E70410 NAD Synthetase / Unkown
HY-I0626S Cytosine-2,4-13C2-1,3-15N2 / Unkown
HY-I0626S1 Cytosine-13C,15N2 / Unkown
HY-N1097 Venoterpine / Unkown
HY-N12653 Exserohilone Inhibitor / Unkown
HY-N13380 6′‐O‐Galloylsalidroside / Unkown
HY-N2550 (+)-Coclaurine / Unkown
HY-N3612 Communic acid Inhibitor / Unkown
HY-N6883 6-Methoxytricin Inhibitor / Unkown
HY-N8375 Sieboldin Inhibitor / Unkown
HY-P0095 Acetyl tetrapeptide-5 Inhibitor 98.05% Unkown
HY-P0104 Palmitoyl tripeptide-38 Inhibitor / Unkown
HY-P10140 JNK-IN-15, Cell-Permeable Inhibitor / Unkown
HY-P10141 JNK-IN-15, Cell-Permeable, Negative Control Inhibitor / Unkown
HY-P10611 [D-Ser14]-Humanin / Unkown
HY-P4308 Z-Pro-Pro-aldehyde-dimethyl acetal Inhibitor / Unkown
HY-RS00444 AGER Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W127725 Thymolphthalexon tetrasodium / Unkown
HY-W127738 6-O-Stearoyl-L-ascorbic acid / Unkown
HY-107758 Y-29794 oxalate Inhibitor / Unkown
HY-113033 Pentosidine / Unkown
HY-113127 L-Tryptophanamide / Unkown
HY-123754 AGN-201904 Inhibitor / Unkown
HY-123904 UoS12258 Activator / Unkown
HY-130221 (25S)-Δ7-Dafachronic acid / Unkown
HY-131528 Tenilsetam / Unkown
HY-145545 1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE / Unkown
HY-14567 Ciproxifan Antagonist / Unkown
HY-149708 UCM-13207 Inhibitor / Unkown
HY-154951 Oct4 inducer-2 Inducer / Unkown
HY-164066 Sodium Acetylated Hyaluronate / Unkown
HY-N1190 DL-Syringaresinol Inhibitor / Unkown
HY-N12071 Lucidin-ω-Me ether / Unkown
HY-N12486 Isofalcarintriol / Unkown
HY-N13232 Grape Skin Extract / Unkown
HY-N15147 Panax saponin C Activator / Unkown
HY-N8380 (-)-Latifolin / Unkown
HY-W268155 3,4'-Dihydroxypropiophenone / Unkown
HY-W701069 Isomyosmine / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9951A Ranibizumab (anti-VEGF) Inhibitor 98.08% Unkown
HY-P99905 Efdamrofusp alfa / Unkown
HY-P99402 Rinucumab Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ager NCBI NCBI:177
Macaca fascicularis Ager NCBI NCBI:102121124