AGER - advanced glycosylation end-product specific receptor Gene

Homo sapiens

Also known as RAGE; sRAGE; SCARJ1

Gene ID: 177 | Gene type: protein coding

About AGER

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,180,969-32,184,253 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 170 orthologues and 3 paralogues. Biased expression in lung (RPKM 397.6) and spleen (RPKM 11.0).

Summary

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]

AGER Products(9)

mRNA	Protein	Name
NM_001136.5	NP_001127.1	advanced glycosylation end product-specific receptor isoform 1 precursor
NM_001206929.2	NP_001193858.1	advanced glycosylation end product-specific receptor isoform 2 precursor
NM_001206932.2	NP_001193861.1	advanced glycosylation end product-specific receptor isoform 3 precursor
NM_001206934.2	NP_001193863.1	advanced glycosylation end product-specific receptor isoform 4 precursor
NM_001206936.2	NP_001193865.1	advanced glycosylation end product-specific receptor isoform 5 precursor
NM_001206940.2	NP_001193869.1	advanced glycosylation end product-specific receptor isoform 6 precursor
NM_001206954.2	NP_001193883.1	advanced glycosylation end product-specific receptor isoform 8 precursor
NM_001206966.2	NP_001193895.1	advanced glycosylation end product-specific receptor isoform 6 precursor
NM_172197.3	NP_751947.1	advanced glycosylation end product-specific receptor isoform 7 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables S100 protein binding	IPI IPI: Inferred from physical interaction	15033494	GOA
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	29518356	GOA
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	22406537	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	24119142	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	22194616	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16061848	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	29518356	GOA
enables signaling receptor activity	IMP IMP: Inferred from mutant phenotype	15457210	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in astrocyte activation	IGI IGI: Inferred from genetic interaction	15457210	GOA
involved in glucose mediated signaling pathway	IDA IDA: Inferred from direct assay	25689357	GOA
involved in learning or memory	IGI IGI: Inferred from genetic interaction	15457210	GOA
involved in microglial cell activation	IGI IGI: Inferred from genetic interaction	15457210	GOA
involved in negative regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	22473704	GOA
involved in negative regulation of long-term synaptic depression	IGI IGI: Inferred from genetic interaction	20739563	GOA
involved in negative regulation of long-term synaptic potentiation	IGI IGI: Inferred from genetic interaction	15457210	GOA
involved in neuron projection development	IGI IGI: Inferred from genetic interaction	10391939	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IGI IGI: Inferred from genetic interaction	15457210	GOA
involved in positive regulation of JNK cascade	IGI IGI: Inferred from genetic interaction	20739563	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	10391939	GOA
involved in positive regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	15944249	GOA
involved in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IGI IGI: Inferred from genetic interaction	22406537	GOA
involved in positive regulation of dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	15944249	GOA
involved in positive regulation of heterotypic cell-cell adhesion	IGI IGI: Inferred from genetic interaction	11078691	GOA
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	15944249	GOA
involved in positive regulation of monocyte extravasation	IMP IMP: Inferred from mutant phenotype	11078691	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IGI IGI: Inferred from genetic interaction	15457210	GOA
involved in positive regulation of p38MAPK cascade	IGI IGI: Inferred from genetic interaction	20739563	GOA
involved in positive regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	15457210	GOA
involved in regulation of CD4-positive, alpha-beta T cell activation	IDA IDA: Inferred from direct assay	22473704	GOA
involved in regulation of T cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	22473704	GOA
involved in regulation of spontaneous synaptic transmission	IGI IGI: Inferred from genetic interaction	15457210	GOA
involved in transport across blood-brain barrier	IDA IDA: Inferred from direct assay	23973487	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	26005850	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGER Protein Structure

Ig_2

C2-set_2

Ig_2

0
100
200
300
404 a.a.

Protein Preferred Names

Protein Names

advanced glycosylation end product-specific receptor

receptor for advanced glycation end-products

Recombinant AGER Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7467	AGER Protein, Human (HEK293, His)	Q15109 (A23-A344)	≥95%
HY-P74604	AGER Protein, Human (HEK293, hFc)	Q15109 (Q24-A344)	≥95%
HY-P74605	AGER Protein, Human (HEK293)	Q15109 (A23-A344)	≥95%
HY-P700146AF	Animal-Free AGER Protein, Human (His)	Q15109 (A23-S300)	≥95%

Related Diseases

Diseases

Alias

Diabetic Angiopathy

Diabetic Angiopathies	Diabetic Peripheral Angiopathy
Diabetic Vascular Disorder

Diabetic Neuropathy

Diabetic Neuropathies

Hyperglycemia

Leukostasis

Microvascular Complications Of Diabetes 5

Diabetic Retinopathy	Microvascular Complications Of Diabetes, Susceptibility To, 5
MVCD5	Retinopathy, Diabetic
Diabetic Nephropathy	Retinopathy, Diabetic, Susceptibility To
Retinal Abnormality - Diabetes-Related

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Kidney Disease

Renal Failure	Kidney Failure
Kidney Diseases	Nephropathy
Abnormality Of The Kidney	Impaired Renal Function Disease
Renal Anomaly	Kidney Dysfunction
Renal Disease	Nephropathies
Renal Failure Adverse Event	Abnormal Renal Function

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Diabetes Mellitus

Diabetes

Atherosclerosis Susceptibility

Atherosclerosis	Atherosclerosis, Susceptibility To
ATHS	Atherogenic Lipoprotein Phenotype
Alp	Arteriosclerosis

Granulomatosis With Polyangiitis

GPA	Wegener Granulomatosis
Wegener Granulomatosis, Formerly	Midline Granulomatosis
Wg, Formerly	Necrotizing Respiratory Granulomatosis
Wg	Wegeners Granulomatosis
Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Brain Edema

Cerebral Edema	Intracranial Swelling
Wet Brain

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Microvascular Complications Of Diabetes 3

Diabetic Nephropathy	Microvascular Complications Of Diabetes, Susceptibility To, 3
MVCD3	Nephropathy, Diabetic
Nephropathy, Diabetic, Susceptibility To	End-Stage Renal Disease, Diabetic
End-Stage Renal Disease, Diabetic, Susceptibility To	Diabetic End-Stage Renal Disease
Diabetic Nephropathies

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Pelvic Organ Prolapse

Rectal Prolapse	Pelvic Organ Prolapse, Susceptibility To, 1
Pelvic Organ Prolapse, Susceptibility To	Prolapse Of Vagina And Rectum
Vaginal Prolapse	Pelvic Organ Prolapse 1
Procidentia, Rectum	Prolapse Of Rectal Mucosa
Procidentia Of Rectum	Rectal Mucosa Prolapse
Rectum Prolapse	Procidentia Rectum
Rp - [Rectal Prolapse]	Male Proctocele
Male Rectocele	Proctoptosis
Female Genital Prolapse	Female Prolapse
Incompetence Of Pelvic Fundus	Relaxation Of Perineum
Deficiency Of Perineum

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Cardiomyopathy, Familial Hypertrophic, 6

Hypertrophic Cardiomyopathy 6	CMH6
Familial Hypertrophic Cardiomyopathy With Wolff-Parkinson-White Syndrome	Cardiomyopathy, Familial Hypertrophic 6
Cardiomyopathy, Hypertrophic 6	Cardiomyopathy, Hypertrophic, Familial, Type 6

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Partial Third-Nerve Palsy

Partial Third Nerve Palsy	Third Nerve Palsy With Pupil Sparing
Third Or Oculomotor Nerve Palsy, Partial	Oculomotor Nerve Diseases
Oculomotor Nerve Paralysis

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0146	Verteporfin		99.58%	Yes
HY-16561	Resveratrol		99.94%	Yes
HY-113416	Dehydroepiandrosterone sulfate		99.28%	Unkown
HY-B0167A	Sodium Salicylate		99.93%	Yes
HY-147080	Avacincaptad pegol sodium	Inhibitor	98.53%	Unkown
HY-109561	Pegaptanib sodium	Inhibitor	98.09%	Unkown
HY-14892	Gemigliptin	Inhibitor	/	Unkown
HY-B0146R	Verteporfin (Standard)		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108801	Aflibercept	Inhibitor	97.90%	Unkown
HY-P99116	Faricimab	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Phase
HY-I0626	Cytosine		99.99%	Phase 4
HY-106024B	Alagebrium chloride	Inhibitor	99.93%	Phase 3
HY-W013494	L-Carnosine		99.94%	Phase 3
HY-19720A	Emixustat hydrochloride		99.59%	Phase 3
HY-19720	Emixustat	Inhibitor	98.00%	Phase 3
HY-B1745	Pyridoxylamine		99.91%	Phase 3
HY-16467	Squalamine lactate	Inhibitor	98.27%	Phase 3
HY-116098	Anecortave desacetate		98.36%	Phase 3
HY-153484	Bevasiranib	Inhibitor	/	Phase 3
HY-153484A	Bevasiranib sodium	Inhibitor	/	Phase 3
HY-112499	Menaquinone-7		≥98.0%	Phase 2
HY-128973	Pyropheophorbide-a		≥98.0%	Phase 2
HY-P3204	POT-4	Inhibitor	99.64%	Phase 2
HY-136788	ALK4290	Inhibitor	99.79%	Phase 2
HY-128850	N-Acetyl-D-mannosamine		≥98.0%	Phase 2
HY-10186	TG 100801	Inhibitor	98.61%	Phase 2
HY-112499R	Menaquinone-7 (Standard)		/	Phase 2
HY-P3204A	POT-4 TFA	Inhibitor	/	Phase 2
HY-P5285	Lunasin	Inhibitor	/	Phase 2
HY-W250163	NAD+ lithium		/	Phase 2
HY-10187	TG 100801 Hydrochloride	Inhibitor	/	Phase 2
HY-14564	GTS-21	Agonist	/	Phase 2
HY-N0088	Apocynin	Inhibitor	99.96%	Phase 1
HY-136093A	Lixumistat acetate	Activator	99.88%	Phase 1
HY-N0160	Kinetin		99.47%	Phase 1
HY-W050154	Kojic acid	Inhibitor	99.99%	Phase 1
HY-N1420	Rhamnose		≥98.0%	Phase 1
HY-15114	S 17092	Inhibitor	98.42%	Phase 1
HY-136093	Lixumistat hydrochloride	Activator	/	Phase 1
HY-16387	PF 00337210	Inhibitor	/	Phase 1
HY-19692	Itasetron	Antagonist	/	Phase 1

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108801A	Aflibercept (VEGF Trap)	Inhibitor	97.66%	Phase 4
HY-P99298	Lampalizumab	Inhibitor	99.46%	Phase 3
HY-P99576	Tarcocimab	Inhibitor	98.35%	Phase 3
HY-P99629	Galegenimab	Inhibitor	99.91%	Phase 2

Pre-clinical Phase

Bioactive Molecules (169)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131042	NNMTi	Inhibitor	99.80%	Unkown
HY-N0664	Aucubin	Inhibitor	99.49%	Unkown
HY-N1485	Cycloastragenol	Activator	≥98.0%	Unkown
HY-126255	SBI-797812	Activator	99.74%	Unkown
HY-N0568	Madecassoside		99.58%	Unkown
HY-N0033	Poliumoside	Inhibitor	99.80%	Unkown
HY-103157	PD146176		99.16%	Unkown
HY-N0295	Protocatechualdehyde	Inhibitor	99.98%	Unkown
HY-129460	XJB-5-131	Inhibitor	99.9%	Unkown
HY-147059	Dieckol		99.81%	Unkown
HY-11068	SB 239063	Inhibitor	99.61%	Unkown
HY-147313	TH10785	Activator	99.93%	Unkown
HY-120912	Gingerenone A	Activator	99.70%	Unkown
HY-129380	Fructosyl-lysine		≥95.0%	Unkown
HY-150069	UBX1325		99.16%	Unkown
HY-110195	Smurf1-IN-A01		99.81%	Unkown
HY-137817	BCH001	Inhibitor	98.83%	Unkown
HY-16561R	Resveratrol (Standard)		99.73%	Unkown
HY-N2292	Kinsenoside		99.91%	Unkown
HY-N0012	Glycitin	Inhibitor	99.84%	Unkown
HY-P1928	Humanin	Inhibitor	≥95.0%	Unkown
HY-W013573	S-Allyl-L-cysteine	Inducer	98.64%	Unkown
HY-P1149A	Epitalon TFA	Activator	99.62%	Unkown
HY-N2485	4'-Methoxyresveratrol		99.48%	Unkown
HY-14892A	Gemigliptin tartrate	Inhibitor	98.17%	Unkown
HY-129566	Withanolide B	Activator	≥99.0%	Unkown
HY-N5135	Liriopesides B		99.85%	Unkown
HY-N7690	3,5,7,3′,4′-Pentamethoxyflavone	Inhibitor	99.15%	Unkown
HY-107811	Harmol		99.77%	Unkown
HY-N6818	5,7,4'-Trimethoxyflavone		99.65%	Unkown
HY-106353	Smilagenin	Agonist	≥98.0%	Yes
HY-128463	N-tert-Butyl-α-phenylnitrone	Inhibitor	99.94%	Unkown
HY-129380A	Fructosyl-lysine dihydrochloride		≥95.0%	Unkown
HY-B1745A	Pyridoxylamine dihydrochloride		99.95%	Unkown
HY-N6588	3,4,5-Tricaffeoylquinic acid	Inhibitor	98.71%	Unkown
HY-P1149	Epitalon	Activator	98.67%	Yes
HY-P3252A	Pegcetacoplan acetate	Inhibitor	98.72%	Unkown
HY-113303	FAPy-adenine		99.95%	Unkown
HY-133968	24-Methylenecholesterol	Activator	99.48%	Unkown
HY-101528	IDRA 21	Modulator	99.33%	Unkown
HY-N4089	Quercetin 3-gentiobioside	Inhibitor	99.92%	Unkown
HY-76383	LR-90	Inhibitor	99.59%	Unkown
HY-B1340	Carbadox	Inhibitor	≥98.0%	Unkown
HY-N4170	Chebulic acid		99.91%	Unkown
HY-P5904	Caveolin-1 (82-101) amide (human, mouse, rat)	Inhibitor	98.48%	Unkown
HY-15289	Ciproxifan maleate	Antagonist	99.75%	Unkown
HY-B1169	Timonacic		≥98.0%	Unkown
HY-N1517	Ganoderic acid C2		99.30%	Unkown
HY-156781	Sirtuin-1 inhibitor 1	Inhibitor	98.09%	Unkown
HY-110291	A-971432	Agonist	≥99.0%	Unkown
HY-132126	SPHINX	Inhibitor	99.87%	Unkown
HY-147108	Mitochondria degrader-1	Inducer	95.10%	Unkown
HY-16561S	Resveratrol-d4		≥99.0%	Unkown
HY-N2278	Kushenol A	Inhibitor	99.84%	Unkown
HY-N7628	Cassiaside C		99.90%	Unkown
HY-114653	SRPIN803	Inhibitor	99.17%	Unkown
HY-133859	M084	Inhibitor	/	Unkown
HY-154847	WM-662	Inhibitor	99.48%	Unkown
HY-N3127	Orobol	Inhibitor	99.28%	Unkown
HY-W286743	Nε-(Carboxymethyl)-L-lysine		99.70%	Unkown
HY-159062	Goji Extract	Activator	/	Unkown
HY-N2550A	(+)-Coclaurine hydrochloride		99.09%	Unkown
HY-N2947	Boeravinone B	Inhibitor	≥97.0%	Unkown
HY-N9347	Stepharine	Inhibitor	≥98.0%	Unkown
HY-117924	AUTEN-67	Inducer	≥92.0%	Unkown
HY-W013494S	L-Carnosine-d4		99.00%	Unkown
HY-11053	S 24795	Agonist	99.66%	Unkown
HY-124609	CAD031	Inhibitor	99.39%	Unkown
HY-126487A	H-Arg-Lys-OH TFA		99.86%	Unkown
HY-145486	1-Arachidonoyl-sn-glycerol 3-phosphate ammonium		/	Unkown
HY-153917	CRT0063465		99.59%	Unkown
HY-15492	AG-13958	Inhibitor	99.71%	Unkown
HY-65008	N-Demethylricinine		99.84%	Unkown
HY-I0626S2	Cytosine-d2		99.69%	Unkown
HY-N12486A	(3S,8R,9R)-Isofalcarintriol		/	Unkown
HY-N2284	Sophoflavescenol	Inhibitor	98.15%	Unkown
HY-N3757	(+)-Dihydrorobinetin		≥98.0%	Unkown
HY-N7426	3-Deoxyglucosone		/	Unkown
HY-P2096	Hexapeptide-11	Inhibitor	99.52%	Unkown
HY-Q49697	Sirtuin modulator 3	Modulator	99.32%	Unkown
HY-163690	HTRA1-IN-1	Inhibitor	/	Unkown
HY-164159	α-Glucosylrutin	Inhibitor	/	Unkown
HY-158821	ISTH0036		/	Unkown
HY-158821A	ISTH0036 sodium		/	Unkown
HY-43515	ESI1		/	Unkown
HY-106024A	Alagebrium bromide		/	Unkown
HY-107652	AF-DX 384	Antagonist	/	Unkown
HY-113033A	Pentosidine TFA		/	Unkown
HY-116780A	Prothipendyl hydrochloride	Inhibitor	/	Unkown
HY-124223	AF-DX 384 methanesulfonate	Antagonist	/	Unkown
HY-128463S	N-tert-Butyl-α-phenylnitrone-d14		/	Unkown
HY-133804	Arteanoflavone	Inhibitor	/	Unkown
HY-133968S1	24-Methylenecholesterol-13C		/	Unkown
HY-136788A	ALK4290 dihydrochloride	Inhibitor	/	Unkown
HY-138830A	(S,S)-TAK-418		/	Unkown
HY-139464	Q134R		99.55%	Unkown
HY-142025	Daumone		/	Unkown
HY-142778	Lp-PLA2-IN-10		/	Unkown
HY-14567A	Ciproxifan hydrochloride	Antagonist	/	Unkown
HY-148322	Sirtuin modulator 5	Modulator	/	Unkown
HY-151487	CypD-IN-3	Inhibitor	/	Unkown
HY-151488	CypD-IN-4	Inhibitor	/	Unkown
HY-151489	CypE-IN-1	Inhibitor	/	Unkown
HY-151546	MRS4596	Antagonist	/	Unkown
HY-151547	MRS4719	Antagonist	/	Unkown
HY-153183	Lp-PLA2-IN-12	Inhibitor	/	Unkown
HY-153560	Lp-PLA2-IN-14	Inhibitor	/	Unkown
HY-15492A	AG-13958 (mono(hydrochloride))	Inhibitor	/	Unkown
HY-155138	GLS1 Inhibitor-7	Inhibitor	/	Unkown
HY-155988	Sirtuin modulator 6	Modulator	/	Unkown
HY-156023	Sirtuin modulator 7	Modulator	99.28%	Unkown
HY-157421	Nampt activator-4	Modulator	/	Unkown
HY-159007	BD-AcAc2		/	Unkown
HY-161088	Anti-aging agent 1		/	Unkown
HY-162269	Nampt activator-5	Activator	/	Unkown
HY-162515	8-OAc		/	Unkown
HY-162866	CXM102	Activator	/	Unkown
HY-162904	BPU17		/	Unkown
HY-162968	MRTF-A-IN-1	Inhibitor	/	Unkown
HY-162969	MRTF-A-IN-2	Inhibitor	/	Unkown
HY-163403	VEGFR-2-IN-43	Inhibitor	/	Unkown
HY-16561G	Resveratrol (GMP)		/	Unkown
HY-16561S1	Resveratrol-13C6		/	Unkown
HY-167740	Glycerophosphoinositol (lysine)		/	Unkown
HY-169085	LRAT-IN-1		/	Unkown
HY-169265	BRD-K20733377	Inhibitor	/	Unkown
HY-169266	BRD-K56819078	Inhibitor	/	Unkown
HY-66018	Palmitoyl tripeptide-5 biTFA		/	Unkown
HY-B0801AS	Fexofenadine-d10 hydrochloride	Inhibitor	/	Unkown
HY-B1340S	Carbadox-d3	Inhibitor	/	Unkown
HY-E70022	D-Mannose isomerase (PsMaSeAF)		/	Unkown
HY-E70410	NAD Synthetase		/	Unkown
HY-I0626S	Cytosine-2,4-13C2-1,3-15N2		/	Unkown
HY-I0626S1	Cytosine-13C,15N2		/	Unkown
HY-N1097	Venoterpine		/	Unkown
HY-N12653	Exserohilone	Inhibitor	/	Unkown
HY-N13380	6′‐O‐Galloylsalidroside		/	Unkown
HY-N2550	(+)-Coclaurine		/	Unkown
HY-N3612	Communic acid	Inhibitor	/	Unkown
HY-N6883	6-Methoxytricin	Inhibitor	/	Unkown
HY-N8375	Sieboldin	Inhibitor	/	Unkown
HY-P0095	Acetyl tetrapeptide-5	Inhibitor	98.05%	Unkown
HY-P0104	Palmitoyl tripeptide-38	Inhibitor	/	Unkown
HY-P10140	JNK-IN-15, Cell-Permeable	Inhibitor	/	Unkown
HY-P10141	JNK-IN-15, Cell-Permeable, Negative Control	Inhibitor	/	Unkown
HY-P10409	SHLP2		99.18%	Unkown
HY-P10611	[D-Ser14]-Humanin		/	Unkown
HY-P4308	Z-Pro-Pro-aldehyde-dimethyl acetal	Inhibitor	/	Unkown
HY-RS00444	AGER Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W127725	Thymolphthalexon tetrasodium		/	Unkown
HY-W127738	6-O-Stearoyl-L-ascorbic acid		/	Unkown
HY-107758	Y-29794 oxalate	Inhibitor	/	Unkown
HY-113033	Pentosidine		/	Unkown
HY-113127	L-Tryptophanamide		/	Unkown
HY-123754	AGN-201904	Inhibitor	/	Unkown
HY-130221	(25S)-Δ7-Dafachronic acid		/	Unkown
HY-131528	Tenilsetam		/	Unkown
HY-145545	1-Stearoyl-2-Adrenoyl-sn-glycero-3-PE		/	Unkown
HY-14567	Ciproxifan	Antagonist	/	Unkown
HY-149708	UCM-13207	Inhibitor	/	Unkown
HY-154951	Oct4 inducer-2	Inducer	/	Unkown
HY-164066	Sodium Acetylated Hyaluronate		/	Unkown
HY-N1190	DL-Syringaresinol	Inhibitor	/	Unkown
HY-N12071	Lucidin-ω-Me ether		/	Unkown
HY-N12486	Isofalcarintriol		/	Unkown
HY-N13232	Grape Skin Extract		/	Unkown
HY-N8380	(-)-Latifolin		/	Unkown
HY-W268155	3,4'-Dihydroxypropiophenone		/	Unkown
HY-W701069	Isomyosmine		/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9951A	Ranibizumab (anti-VEGF)	Inhibitor	98.08%	Unkown
HY-P99905	Efdamrofusp alfa		/	Unkown
HY-P99402	Rinucumab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AGER	MGD	MGI:893592
Canis familiaris	AGER	VGNC	VGNC:37699
Rattus norvegicus	AGER	RGD	RGD:69258
Macaca mulatta	AGER	VGNC	VGNC:69743
Bos taurus	AGER	VGNC	VGNC:25724
Felis catus	AGER	VGNC	VGNC:59680
Macaca fascicularis	AGER	NCBI	NCBI:102121124
Others	AGER	NCBI