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Results for "

HEPG-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acyltransferase (1) Akt (7) Aldehyde Dehydrogenase (ALDH) (1) AMPK (4) Amyloid-β (2) Angiotensin Receptor (3) Antibiotic (5) Apoptosis (88) Atg8/LC3 (1) Autophagy (12) Bacterial (17) Bcl-2 Family (8) BCRP (1) Beclin1 (1) Biochemical Assay Reagents (4) c-Met/HGFR (2) c-Myc (2) Calcium Channel (2) CaMK (1) Carbonic Anhydrase (2) Caspase (12) CDK (6) Cholinesterase (ChE) (1) ClpP (1) COX (6) Cyclophilin (1) Cytochrome P450 (9) Dihydrofolate reductase (DHFR) (2) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) Drug Metabolite (1) EGFR (12) Endogenous Metabolite (7) Endothelin Receptor (1) Ephrin Receptor (1) Epigenetic Reader Domain (2) ERK (1) Ferroptosis (3) Fluorescent Dye (5) Free Fatty Acid Receptor (1) Fungal (7) GABA Receptor (2) Glucocorticoid Receptor (1) Glucosidase (2) GLUT (2) HBV (20) HCV (1) HDAC (2) Histone Acetyltransferase (1) Histone Demethylase (2) Histone Methyltransferase (2) HIV (5) HMG-CoA Reductase (HMGCR) (6) HSP (2) Insulin Receptor (1) Interleukin Related (2) Isotope-Labeled Compounds (6) JAK (2) Keap1-Nrf2 (1) Ketohexokinase (2) LDLR (1) LXR (2) MAP3K (1) MDM-2/p53 (3) MetAP (1) Microtubule/Tubulin (15) Mitophagy (6) MMP (5) mTOR (3) Na+/K+ ATPase (1) nAChR (1) NAMPT (2) Necroptosis (1) NF-κB (13) NO Synthase (6) P-glycoprotein (4) p38 MAPK (2) Parasite (11) PARP (3) PCSK9 (3) PD-1/PD-L1 (2) PERK (3) Phosphodiesterase (PDE) (3) PI3K (3) Pim (4) PKA (1) PKC (2) Polo-like Kinase (PLK) (1) PPAR (2) Protease Activated Receptor (PAR) (1) Proteasome (1) Raf (3) Reactive Oxygen Species (15) Reverse Transcriptase (2) ROCK (1) Ser/Thr Protease (1) Sodium Channel (1) SphK (1) Src (4) STAT (2) Stearoyl-CoA Desaturase (SCD) (4) Thyroid Hormone Receptor (2) TNF Receptor (3) Topoisomerase (5) TrxR (1) Tyrosinase (1) VEGFR (20) Wnt (1) YAP (1)
By Research Areas:	Cancer (225) Cardiovascular Disease (17) Endocrinology (2) Infection (61) Inflammation/Immunology (25) Metabolic Disease (41) Neurological Disease (16)
Click Chemistry:	Azide (1)
Oligonucleotides:	Aptamers (1)

335

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

104

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0876

Arenobufagin 3 Publications Verification	Others	Cancer
Arenobufagin is a natural bufadienolide from toad venom; has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.

HY-147839

Topoisomerase II inhibitor 10	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 10 (compound 32a) is a potent topoisomerase II inhibitor with an IC₅₀ value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells .

HY-156097

Anticancer agent 158	Others	Cancer
Anticancer agent 158 (compound 7c) is a potent anticancer agent. The IC₅₀s for inhibiting HepG-2, MDA-MB-231, and HCT-116 cell lines are 7.93 μM, 9.28 μM, 13.28 μM, and 181.89 μM, respectively .

HY-155027

DPP-4-IN-8	Dipeptidyl Peptidase TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
DPP-4-IN-8 (compound 27) is a potent and selective DPP4 (dipeptidyl peptidase 4) inhibitor, with a K_i of 0.96 μM. DPP-4-IN-8 blocks the dipeptidase activity of DPP4 in both Caco-2 and HepG-2 cells. DPP-4-IN-8 also dose-dependently suppresses the expression levels of the chemokines tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) .

HY-N10853

3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone	Others	Cancer
3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone is a nature product that could be isolated from the fruits of Vitex rotundifolia. 3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone has potent cytotoxic activity against A549 and HepG-2 cell lines .

HY-168067

CDK-IN-14	CDK Caspase Apoptosis	Cancer
CDK-IN-14 (B34) is a *CDK2* inhibitor (IC₅₀=0.097 μM) with anti-hepatocellular carcinoma activity. CDK-IN-14 blocks the cell cycle of HepG-2 cancer cells through a caspase-mediated mechanism and induces apoptosis .

HY-157324

EGFR-IN-94	EGFR Apoptosis VEGFR	Cancer
EGFR-IN-94 (compound 5a) is a EGFR inhibitor with IC₅₀ of 0.086?μM, and also has IC₅₀ of 0.107μM and 2.52 μM for *VEGFR-2* and Topo II, respectively. EGFR-IN-94 induces cell apoptosis and arrests cell cycle at the S phase in HepG-2 cells .

HY-149815

HBV-IN-33	HBV	Infection Inflammation/Immunology
HBV-IN-33 (C-49), a HBV inhibitor, notably suppresses HBV replication in HepAD38, HepG2-HBV1.3 and HepG2-NTCP cells .

HY-163615

Antimicrobial agent-32	Bacterial	Infection
Antimicrobial agent-32 (Compound 4g) is an antimicrobial agent that exhibits significant activity against various bacteria, including Staphylococcus aureus, Bacillus subtilis, Bacillus cereus (MIC=1000 µg/mL), Klebsiella pneumonia, and Staphylococcus aureus (MRSA) (MIC=500 µg/mL), as well as Escherichia coli (MIC=250 µg/mL). Additionally, Antimicrobial agent-32 inhibits the proliferation of MCF-7, HCT-116, and HepG-2 cells, demonstrating anticancer activity .

HY-146465

Anticancer agent 60	Microtubule/Tubulin	Cancer
Anticancer agent 60 (compound 3h) has antiproliferative activity against human HepG2 cells (IC₅₀ = 4.13 μM) and presents antitumor efficacy in a human HepG2 xenograft mouse model .

HY-N10063

Penispidin A	Others	Metabolic Disease
Penispidin A inhibits hepatic lipid accumulation in HepG2 cells.

HY-122324

Tylophorine (+)-(S)-Tylophorine; DCB-3500; NSC-717335	Others	Cancer
Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation .

HY-133667

Bromoiodoacetamide	Apoptosis	Cancer
Bromoiodoacetamide is a kind of iodinated haloacetamides (I-HAcAms), with cytotoxicity. Bromoiodoacetamide induces cytotoxicity by via reactive oxygen species (ROS) accumulation and apoptosis in HepG-2 cells .

HY-N12706

Heilaohuguosu G	Endogenous Metabolite	Endocrinology
Heilaohuguosu G (compound 7) is a cyclolignan with hepatoprotective activity. Heilaohuguosu G against APAP toxicity with cell survival rates at 10 μM of 45.7% in HepG-2 cells .

HY-137605

WSF1-IN-1	Others	Cancer
WSF1-IN-1 (compound 136), an orally active WSF1 inhibitor, can be used in the study for WSF1 (Wolfram syndrome) related tumors, with IC₅₀ values of 0.33 μM and >27 μM in HepG2 parental and HepG2 WFS1 KO cell lines, respectively .

HY-N9010

Chartarlactam A	Others	Metabolic Disease
Chartarlactam A is a novel compound with anti-hyperlipidemic activity. Chartarlactam A exhibits inhibitory potential in HepG2 cells .

HY-156085

LP23	PD-1/PD-L1	Cancer
LP23 is a non-arylmethylamine PD-1/PD-L1 inhibitor (IC₅₀: 16.7 nM) with anti-tumor activity. LP23 restores immune cell function in HepG2/Jurkat T cells and promotes HepG2 cell death. LP23 is active in vivo in the B16-F10 tumor model (TGI=88.6% at 30 mg/kg) .

HY-151066

BMS-1233	PD-1/PD-L1	Cancer
BMS-1233 is an orally active inhibitor for programmed cell death-ligand 1 (PD-L1), with IC₅₀ of 14.5 nM. BMS-1233 promotes cell death of HepG2 in a Jurkat T cell and HepG2 cell co-culture model, exhibits antitumor activity against melanoma in mouse model .

HY-13623A

Entecavir monohydrate Maximum Cited Publications 15 Publications Verification BMS200475 monohydrate; SQ34676 monohydrate	HBV	Infection Cancer
Entecavir monohydrate (BMS200475 monohydrate; SQ34676 monohydrate) is a potent and selective inhibitor of HBV, with an EC₅₀ of 3.75 nM in HepG2 cell.

HY-13623

Entecavir Maximum Cited Publications 15 Publications Verification BMS200475; SQ34676	HBV	Infection Cancer
Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC₅₀ of 3.75 nM in HepG2 cell.

HY-N0125

Diosmetin 5+ Cited Publications	Cytochrome P450	Cancer
Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-N1323

Sanggenol P	HBV	Infection
Sanggenol P, a flavonoid, shows anti-HBV activity on HepG2.2.15 cell line in vitro .

HY-P1935

Cyclo(Ala-Pro)	Biochemical Assay Reagents	Cancer
Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .

HY-N1514

Ganoderenic acid B	P-glycoprotein	Cancer
Ganoderenic acid B is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderenic acid B exhibits potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to Doxorubicin .

HY-N11792

Pedunculosumoside F	Others	Others
Pedunculosumoside F is a homoflavonoid glucoside. Pedunculosumoside F can be isolated from Ophioglossum pedunculosum. Pedunculosumoside F has cytotoxicity against HepG2 22.15 cells with CC₅₀ value of 56.7 μM without anti-HBV activity. While its analogs block HBsAg secretion in HBV-infected HepG2 2.2.15 cells .

HY-N6683

15-Acetyl-deoxynivalenol	Drug Metabolite	Cancer
15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .

HY-N8882

Oleoside 11-methyl ester	Others	Cancer
Oleoside 11-methyl ester is a secoiridoid glucoside and possesses a strong cytotoxic activity against Hep-G2 cells .

HY-116920

Alyssin	Reactive Oxygen Species Microtubule/Tubulin	Cancer
Alyssin, found in Cruciferous Vegetables, exerts anticancer activity in HepG2 by increasing intracellular reactive oxygen species and tubulin depolymerization .

HY-N11433

Celosin L	Others	Others
Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

HY-139425

Cyclo(Pro-Ala)	Biochemical Assay Reagents	Cancer
Cyclo(Pro-Ala) is an anticancer agent that has toxic to cancer cells such as A549, HCT-116, and HepG2 .

HY-N0882

Desacetylcinobufotalin Deacetylcinobufotalin	Apoptosis	Cancer
Desacetylcinobufotalin is a natural compound; apoptosis inducer and shows the marked inhibition effect to HepG2 cells and the IC50 value is 0.0279μmol/ml.

HY-100303A

FR194738 2 Publications Verification	Others	Metabolic Disease
FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC₅₀ of 9.8 nM.

HY-N8934

6β-Hydroxytomentosin	Others	Cancer
6β-Hydroxytomentosin, a sesquiterpenoid, can be found in flowers of Inula japonica. 6β-Hydroxytomentosin exhibits weak cytotoxicities against A549, SK-OV-3, HepG-2 and HT-29 cell lines ^[2].

HY-118224

BPH-715	Parasite	Infection
BPH-715 is a bisphosphonate, inhibits Plasmodium liver-stage growth, with an IC₅₀ of 10 μM for Plasmodium exoerythrocytic forms in HepG2 cells .

HY-109969

Z060228	HBV	Infection
Z060228 is a capsid-targeting anti-HBV agent that inhibits HBV DNA replication in the supernatant of the HepG2.2.15 cell .

HY-100303

FR194738 free base 2 Publications Verification	Others	Metabolic Disease
FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC₅₀ of 9.8 nM.

HY-D1255

Sel-green	Fluorescent Dye	Cancer
Sel-green, a selective selenol fluorescent probe, is applied to quantify the Sec content in the selenoenzyme thioredoxin reductase and image endogenous Sec in live HepG2 cells .

HY-N10207

Penicitide A	Endogenous Metabolite	Infection Cancer
Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line .

HY-145821

Tubulin inhibitor 15	Microtubule/Tubulin	Cancer
Tubulin inhibitor 15 is a potent tubulin inhibitor. Tubulin inhibitor 15 shows antiproliferative activity. Tubulin inhibitor 15 shows cytotoxicity in HepG2 cells .

HY-145822

Tubulin inhibitor 16	Microtubule/Tubulin	Cancer
Tubulin inhibitor 16 is a potent tubulin inhibitor. Tubulin inhibitor 16 shows antiproliferative activity. Tubulin inhibitor 16 shows cytotoxicity in HepG2 cells .

HY-100249

XEN723	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC₅₀s of 45 and 524 nM in mouse and HepG2 cell, respectively.

HY-N8679

Physalin C	Endogenous Metabolite	Cancer
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-N12158

Pipermethystine	Apoptosis	Cancer
Pipermethystine is an alkaloid that can be isolated from the Kava plant. Pipermethystine decreases HepG2 cell cellular ATP levels, mitochondrial membrane potential, and induces apoptosis .

HY-N12426

Heilaohuguosu F	Others	Metabolic Disease
Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.

HY-13623S

Entecavir-d2 BMS200475-d₂; SQ34676-d₂	Isotope-Labeled Compounds HBV	Infection
Entecavir-d₂ is the deuterium labeled Entecavir. Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.

HY-N10089

Psiguadial D	Others	Cancer
Psiguadial D is a terpenoid that can be isolated from Psidium guajava, and it has a strong inhibitory effect on the growth of HepG2 cells, with an IC₅₀value of 128.3 nM .

HY-N12288

Wangzaozin A	Others	Cancer
Wangzaozin A is an ent-kaurene diterpenoid. Wangzaozin A has cytotoxic against HepG2 cells and Tb cells with IC₅₀ of 1.41 μM and 0.32 μM, respectively .

HY-155337

eIF4E-IN-6	Others	Cancer
eIF4E-IN-6(compound 4b) is a GMP analogs synthesized to targeteIF4Eand restrain its binding to cap mRNA.eIF4E-IN-6shows cell cytotoxicity against Caco-2, HepG-2,and MCF-7 cells, withIC₅₀values of 31, 27, and 21 μM, respectively .

HY-16679

Helioxanthin derivative 5-4-2 1 Publications Verification Helioxanthin 5-4-2	HBV	Infection
Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells.

HY-11034

CVT-12012	Stearoyl-CoA Desaturase (SCD)	Metabolic Disease
CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC₅₀s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively.

Cat. No.	Product Name	Type

HY-D1255

Sel-green	Fluorescent Dyes/Probes
Sel-green, a selective selenol fluorescent probe, is applied to quantify the Sec content in the selenoenzyme thioredoxin reductase and image endogenous Sec in live HepG2 cells .

HY-162129

Antitumor agent-131	Fluorescent Dyes/Probes
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC₅₀ value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .

HY-163286

BODIQPy-TPA	Dyes
BODIQPy-TPA is a lipophilic probes, which induces ferroptosis in B16 and HepG2 cells upon light irradiation through lipid peroxidation. BODIQPy-TPA reveals a maximum absorption wavelength of 488 nm and a maximum emission wavelength above 640 nm .

HY-163287

QPy-TPA	Dyes
QPy-TPA is a lipopjilc probes, which induces non-ferroptotic cell death and lipid dynamic regularion in B16 and HepG2 cells upon light irradiation. QPy-TPA reveals a maximum absorption wavelength of 400 nm and a maximum emission wavelength of 590 nm .

HY-D2315

Probe-Cys

Fluorescent Dyes/Probes

Probe-Cys is a water-soluble and selective near-infrared fluorescent probe for Cys (λex= 680 nm, λem=710 nm) that is not interfered by Hcy, GSH, and HS-. Probe-Cys can react with the stimulant 1,4-dimercaptothreitol (DTT) and the inhibitor N-ethylmaleimide (NEM) in HepG2 cells and zebrafish for the detection of endogenous Cys. Probe-Cys can also be used for imaging Cys in Arabidopsis thaliana. Probe-Cys provides a method for cancer diagnosis and exploration of plant sulfur metabolism .

Cat. No.	Product Name	Type

HY-124187

Pinolenic acid ethyl ester

Ethyl pinolenate

Drug Delivery

Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

Cat. No.	Product Name	Target	Research Area

HY-113064

Selenocystine 1 Publications Verification	Endogenous Metabolite	Cancer
Selenocystine is a broad-spectrum anti-cancer agent. Selenocystine induces DNA damage in HepG2 cells, particularly in the form of DNA double strand breaks (DSBs). Selenocystine exhibits great promise as a therapeutic or adjuvant agent targeting DNA repair for cancer treatment .

HY-P1935

Cyclo(Ala-Pro)	Biochemical Assay Reagents	Cancer
Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .

HY-139425

Cyclo(Pro-Ala)	Biochemical Assay Reagents	Cancer
Cyclo(Pro-Ala) is an anticancer agent that has toxic to cancer cells such as A549, HCT-116, and HepG2 .

HY-P4284

Z-GGF-CMK	ClpP Proteasome	Others
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. Z-GGF-CMK exhibits cytotoxic activity against HepG2 cells with a CC₅₀ value of 125 μM .

Cat. No.	Product Name

HY-K2014

PEI Transfection Reagent 5+ Cited Publications
MCE PEI Transfection Reagent is designed based on 25 kDa PEI. It has high-efficiency, low-toxicity, strong-stability, and is suitable for many cell types, such as HEK-293、HEK-293T、CHO-K1、COS-1、COS-7、NIH/3T3、Sf9、HepG2 and HeLa et, even some hard-to-transfect cells. It can also be applied to large-scale recombinant protein expression and virus production.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0876

Arenobufagin 3 Publications Verification	Structural Classification Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Others
Arenobufagin is a natural bufadienolide from toad venom; has potent antineoplastic activity against HCC HepG2 cells as well as corresponding multidrug-resistant HepG2/ADM cells.

HY-N0125

Diosmetin 5+ Cited Publications	Structural Classification Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Flavones Citrus limon (L.) Burm. F. Source classification Rutaceae Plants Endogenous metabolite Disease Research Fields Cancer	Cytochrome P450
Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-N1514

Ganoderenic acid B	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Endogenous metabolite Disease Research Fields Cancer	P-glycoprotein
Ganoderenic acid B is a lanostane-type triterpene isolated from Ganoderma lucidum. Ganoderenic acid B exhibits potent reversal effect on ABCB1-mediated multidrug resistance of HepG2/ADM cells to Doxorubicin .

HY-N10853

3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone	Source classification Vitis rotundifolia Michx. Plants Vitaceae	Others
3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone is a nature product that could be isolated from the fruits of Vitex rotundifolia. 3′,5-Dihydroxy-4′,6,7-trimethoxyflavanone has potent cytotoxic activity against A549 and HepG-2 cell lines .

HY-N10063

Penispidin A	Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Disease Research Fields	Others
Penispidin A inhibits hepatic lipid accumulation in HepG2 cells.

HY-122324

Tylophorine (+)-(S)-Tylophorine; DCB-3500; NSC-717335	Apocynaceae Source classification Plants Tylophora	Others
Tylophorine and its analogs are benzoindole alkaloids, most of which are derived from Garcinia plants. Tylophorine analogs all show potent growth inhibition against human hepatocellular carcinoma HepG2 and human nasopharyngeal carcinoma KB cell lines. Tylophorine analogs can also induce increased albumin expression and inhibit α-fetoprotein expression in HepG2 cells, and have the potential to induce HepG2 cell differentiation .

HY-N12706

Heilaohuguosu G	Structural Classification Source classification Lignans Phenylpropanoids Kadsura coccinea (Lem.) A. C. Smith Plants Schisandraceae	Endogenous Metabolite
Heilaohuguosu G (compound 7) is a cyclolignan with hepatoprotective activity. Heilaohuguosu G against APAP toxicity with cell survival rates at 10 μM of 45.7% in HepG-2 cells .

HY-N9010

Chartarlactam A	Structural Classification Natural Products Microorganisms Source classification	Others
Chartarlactam A is a novel compound with anti-hyperlipidemic activity. Chartarlactam A exhibits inhibitory potential in HepG2 cells .

HY-N1323

Sanggenol P	Structural Classification Flavonoids Flavonones Source classification Plants Moraceae Morus alba Linn.	HBV
Sanggenol P, a flavonoid, shows anti-HBV activity on HepG2.2.15 cell line in vitro .

HY-P1935

Cyclo(Ala-Pro)	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	Biochemical Assay Reagents
Cyclo(Ala-Pro) is an anticancer agent that is toxic to cancer cells such as A549, HCT-116 and HepG2 .

HY-N11792

Pedunculosumoside F	Structural Classification Flavonoids Source classification Ophioglossaceae Plants Other Flavonoids Ophioglossum reticulatum L.	Others
Pedunculosumoside F is a homoflavonoid glucoside. Pedunculosumoside F can be isolated from Ophioglossum pedunculosum. Pedunculosumoside F has cytotoxicity against HepG2 22.15 cells with CC₅₀ value of 56.7 μM without anti-HBV activity. While its analogs block HBsAg secretion in HBV-infected HepG2 2.2.15 cells .

HY-N6683

15-Acetyl-deoxynivalenol	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	Drug Metabolite
15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells .

HY-N8882

Oleoside 11-methyl ester	Iridoids Classification of Application Fields Oleaceae Ligustrum lucidum Ait. Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Oleoside 11-methyl ester is a secoiridoid glucoside and possesses a strong cytotoxic activity against Hep-G2 cells .

HY-N11433

Celosin L	Triterpenes Structural Classification Terpenoids Celosia cristata L. Source classification Amaranthaceae Plants	Others
Celosin L is a triterpenoid saponin with hepaprotective activity. Celosin L exhibits protective effects against APAP-induced hepatotoxicity in HepG2 cells .

HY-N0882

Desacetylcinobufotalin Deacetylcinobufotalin	Classification of Application Fields Animals Source classification Disease Research Fields Steroids Cancer	Apoptosis
Desacetylcinobufotalin is a natural compound; apoptosis inducer and shows the marked inhibition effect to HepG2 cells and the IC50 value is 0.0279μmol/ml.

HY-N8934

6β-Hydroxytomentosin	Phyllodium pulchellum (L.) Desv. Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Compositae Disease Research Fields Cancer	Others
6β-Hydroxytomentosin, a sesquiterpenoid, can be found in flowers of Inula japonica. 6β-Hydroxytomentosin exhibits weak cytotoxicities against A549, SK-OV-3, HepG-2 and HT-29 cell lines ^[2].

HY-N10207

Penicitide A	Infection Natural Products Microorganisms Classification of Application Fields Source classification Marine natural products Disease Research Fields Marine microorganism	Endogenous Metabolite
Penicitide A is a marine secondary metabolite. Penicitide A shows moderate cytotoxicity against pathogen A. brassicae and the human hepatocellular liver carcinoma (HepG2) cell line .

HY-N8679

Physalin C	Structural Classification Cardiacglycosides Source classification Physalis angulata L. Plants Solanaceae Steroids	Endogenous Metabolite
Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells .

HY-N12158

Pipermethystine	Structural Classification Alkaloids Other Alkaloids Source classification Piper methysticum Forst Piperaceae Plants	Apoptosis
Pipermethystine is an alkaloid that can be isolated from the Kava plant. Pipermethystine decreases HepG2 cell cellular ATP levels, mitochondrial membrane potential, and induces apoptosis .

HY-N12426

Heilaohuguosu F	Structural Classification Source classification Lignans Phenylpropanoids Plants Kadsura coccinea (Lem.) A. C. Smith Schisandraceae	Others
Heilaohuguosu F (compound 6) is a tetrahydrofuranolignan with weak hepatoprotective effects. Heilaohuguosu F has a mild protective effect against APAP-induced hepatotoxicity in HepG2 cells.

HY-N10089

Psiguadial D	Structural Classification Terpenoids Sesquiterpenes Source classification Psidium guajava Linn. Myrtaceae Plants	Others
Psiguadial D is a terpenoid that can be isolated from Psidium guajava, and it has a strong inhibitory effect on the growth of HepG2 cells, with an IC₅₀value of 128.3 nM .

HY-N12288

Wangzaozin A	Structural Classification Terpenoids Labiatae Source classification Diterpenoids Plants Kleinia odora (Forssk.) DC.	Others
Wangzaozin A is an ent-kaurene diterpenoid. Wangzaozin A has cytotoxic against HepG2 cells and Tb cells with IC₅₀ of 1.41 μM and 0.32 μM, respectively .

HY-N12440

Sarmenoside II	Structural Classification Source classification Crassulaceae Sedum sarmentosum Bunge Phenols Polyphenols Plants	Others
Sarmenoside II is a flavonol glycoside with activity that inhibits lipid accumulation. Sarmenoside II inhibits albumin-oleate-induced lipid accumulation in HepG2 cells by approximately 30% at 100 μM.

HY-N9532

Isobyakangelicol Anhydrobyakangelicin	Classification of Application Fields Source classification Coumarins Phenylpropanoids Plants Umbelliferae Helogyne apaloidea Nutt. Disease Research Fields Cancer	Others
Isobyakangelicol is a coumarin that can be found in the roots of Angelica dahurica. Isobyakangelicol inhibits the growth of HeLa and HepG2 cells, with IC₅₀s of 70.04 μM and 17.97 μM .

HY-N4067

Isochenodeoxycholic acid isoCDCA	Microorganisms Source classification	Others
Isochenodeoxycholic acid (isoCDCA) is a human fecal bile acid. Isochenodeoxycholic acid has cytoprotective against ethanol-induced cell injuries in HepG2 cells. Isochenodeoxycholic acid is a major metabolite of orally administered ursodeoxycholic acid (UDCA) .

HY-N3121

Pachypodol	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Cancer	Others
Pachypodol exerts antioxidant and cytoprotective effects in HepG2 cells .Pachypodol inhibits the growth of CaCo 2 colon cancer cell line in vitro(IC₅₀ = 185.6 mM) ^[2].

HY-N7464

Jolkinolide E	Structural Classification Terpenoids Source classification Euphorbia rapulum Kar. et Kir. Diterpenoids Euphorbiaceae Plants	Others
Jolkinolide E is a casbane diterpenoid from the roots of Euphorbia rapulum. Jolkinolide E shows weak selective activity against HepG2, MCF-7, and C6 cell lines .

HY-N0907

Ginsenoside Rg6	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NF-κB Apoptosis
Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC₅₀ of 29.34 μM in HepG2 cells. Ginsenoside Rg6 also exhibits apoptosis-inducing effect.

HY-N7605

11-epi-mogroside V	Triterpenes Classification of Application Fields Terpenoids Source classification Cucurbitaceae Metabolic Disease Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields	Others
11-epi-mogroside V is a mogroside in the fruit of Siraitia grosvenori. 11-epi-mogroside V exhibits considerable bioactivity in promoting glucose uptake in human HepG2 cells in vitro .

HY-N9339

Norglaucine (+)-Norglaucine	Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Others
Norglaucine ((+)-Norglaucine), a cytotoxic alkaloid, exhibits cytotoxicity towards the tumor cell lines B16-F10, HepG2, K562 and HL-60 cells .

HY-N8361

Glycoborinine	Structural Classification Alkaloids Glycosmis arborea (Retz.) Corrêa Source classification Rutaceae Plants Indole Alkaloids	HIV Apoptosis
Glycoborinine, a natural carbazole alkaloid, can be isolated from Glycosmis pentaphylla. Glycoborinine induces HepG2 cell apoptosis through mitochondrial pathway. Glycoborinine also inhibits HIV replication in cells ^[2].

HY-N2936

Bi-linderone	Structural Classification Natural Products Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Others
Bi-linderone is isolated as racemate from the traditional Chinese medicinal plant Lindera aggregata. Bi-linderone has activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 μg/mL .

HY-N0125R

Diosmetin (Standard)	Structural Classification Human Gut Microbiota Metabolites Flavonoids Classification of Application Fields Citrus limon (L.) Burm. F. Source classification Rutaceae Plants Endogenous metabolite Disease Research Fields Cancer	Cytochrome P450
Diosmetin (Standard) is the analytical standard of Diosmetin. This product is intended for research and analytical applications. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC₅₀ of 40 μM in HepG2 cell.

HY-126981

Sarasinoside B1	Structural Classification Polysaccharides Marine natural products Source classification Sponge Saccharides	Others
Sarasinoside B1 is a glycoside compound. Sarasinoside B1 exhibits moderate cytotoxicity against Neuro-2a and HepG2 cell lines (IC50=~5-18 μM).

HY-N7273

Soyasaponin III	Triterpenes Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Source classification Plants Disease Research Fields Cancer	Apoptosis
Soyasaponin III, a monodesmodic oleanane triterpenoid, is one of the main potentially bioactive saponins found in soy (Glycine max) and related products. Soyasaponin III can induce apoptosis in Hep-G2 cells .

HY-N1768

(2S)-3',4',7-Trimethoxyflavan	Structural Classification Flavonoids Narcissus tazetta Linn. Source classification Plants Other Flavonoids Amaryllidaceae	Others
(2S)-3',4',7-Trimethoxyflavan is a flavan, exhibits weak cytotoxicities against HCT116 and HepG2 with IC₅₀ values 34.36 μg/mL and 38.51 μg/mL, respectively .

HY-N7760

Neosalvianen	Structural Classification Alkaloids Terpenoids Other Alkaloids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants	Others
Neosalvianen is a N-containing compound that shows cytotoxic activities against the HeLa, HepG2, and OVCAR-3 cell lines, with IC₅₀ of 63.9 µM, 59.2 µM, and 74.6 µM, respectively .

HY-N9966

Sanggenol O	Structural Classification Flavonoids Flavonones Source classification Morus alba L. Plants Moraceae	Others
Sanggenol O? is an active product that can be extracted from Morus alba. Sanggenol O? has hepatoprotective and neuroprotective activities with EC₅₀s more than 80 μM in HepG2 and HT22 cells .

HY-N1324

Sanggenon N	Structural Classification Flavanonols Flavonoids Source classification Phenols Polyphenols Plants Moraceae Morus alba Linn.	Others
Sanggenon N is an isoprenylated flavonoid that can be isolated from the root bark of Morus alba.Sanggenon N has hepatoprotective activities on t-BHP-induced cell cytotoxicity in HepG2 cells with an EC₅₀ of 23.45 μM .

HY-N0906

Ginsenoside Rk3	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	NF-κB
Ginsenoside Rk3 is present in the roots Panax ginseng herbs. Ginsenoside Rk3 significantly inhibits TNF-α-induced NF-κB transcriptional activity, with an IC₅₀ of 14.24±1.30 μM in HepG2 cells.

HY-75564

Cyclo(Ala-Gly)	Natural Products Microorganisms Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC₅₀ values range from 9.5 to 18.1 μM .

HY-N7321

Eucomol	Structural Classification Flavonoids Source classification Plants Other Flavonoids Asparagaceae Juss.	Others
Eucomol has potent cytotoxicity against KKU-M156 and HepG2 cells with the IC₅₀ values of 7.12 and 25.76? μg/mL, respectively. Eucomol can be isolated from an ethanolic extract of D. cochinchinensis .

HY-N2882

Apigenin-4'-α-L-rhamnoside	Ranunculus sieboldii Miq. Structural Classification Flavonoids Flavones Source classification Ranunculaceae Plants	HBV
Apigenin-4'-α-L-rhamnoside is a potent inhibitor of HBV. Apigenin-4'-α-L-rhamnoside inhibits the secretory level of HBV surface antigen (HBsAg) in HepG2.2.15 cells .

HY-N0316

Mollugin 1 Publications Verification	Structural Classification Monophenols Classification of Application Fields Terpenoids Sesquiterpenes Source classification Rubiaceae Phenols Plants Disease Research Fields Rubia cordifolia L. Cancer	JAK NF-κB Reactive Oxygen Species Apoptosis VEGFR c-Myc
Mollugin is an orally active and potent NF-κB inhibitor. Mollugin induces S-phase arrest of HepG2 cells, and increased intracellular reactive oxygen species (ROS) levels. Mollugin induces DNA damage in HepG2 cells, as well as an increase in the expression of p-H2AX. Mollugin shows anti-cancer effect by inhibiting TNF-α-induced NF-κB activation. Mollugin enhances the osteogenic action of BMP-2 (bone morphogenetic protein 2) via the p38-Smad signaling pathway ^[2] .

HY-N10846

Neotriptonoterpene	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Plants Tripterygium wilfordii Hook. f.	Others
Neotriptonoterpene, a compound isolated from T. regelii, shows weak cytotoxic activity against A2780, HepG2 and MCF-7 cells with IC₅₀ values of 65.80, 35.45 and 64.80 µM respectively .

HY-N12128

Ophiopogonin R	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Polysaccharides Liliaceae Source classification Plants Saccharides	Others
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

HY-126644

Halocyamine B	Structural Classification Natural Products Animals Marine natural products Source classification Other marine organisms	Bacterial Fungal
Halocyamine B exhibits antimicrobial activity against a variety of bacteria and yeasts. Halocyamine B exhibits cytotoxicity to cultured neural cells of rat fetal brain, mouse neuroblastoma N18 cells, and human hepatoma HepG2 cells .

HY-N2078

Yamogenin Neodiosgenin	Structural Classification other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields Steroids	LXR
Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes .

HY-N7980

Rubipodanone A	Quinones Structural Classification Classification of Application Fields Rubia podantha Source classification Rubiaceae Plants Naphthalene Quinones Disease Research Fields Cancer	NF-κB
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-120607

Chevalone C	Infection Triterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Disease Research Fields	Parasite
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC₅₀ value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines ^[2].

Cat. No.	Product Name	Chemical Structure

HY-B0144AS1

Pitavastatin-d5 sodium
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-13623S

Entecavir-d2
Entecavir-d₂ is the deuterium labeled Entecavir. Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.

HY-N0125S

Diosmetin-d3
Diosmetin-d₃ is the deuterium labeled Diosmetin. Diosmetin is a natural flavonoid which inhibits human CYP1A enzyme activity with an IC50 of 40 μM in HepG2 cell.

HY-N6683S1

15-Acetyl-deoxynivalenol-13C17
15-Acetyl-deoxynivalenol- ¹³C₁₇ is the ¹³C labeled 15-Acetyl-deoxynivalenol (HY-N6683) . 15-Acetyl-deoxynivalenol is a highly toxic trichothecene found in cereals, and a metabolite of deoxynivalenol, exhibits toxicity to HepG2 cells ^[2].

HY-19937S1

Saroglitazar-d4
Saroglitazar-d₄ is the deuterium-labeled Saroglitazar (HY-19937). Saroglitazar-d₄ is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC₅₀ values of 0.65 pM and 3 nM in HepG2 cells, respectively.

HY-13623S1

Entecavir-13C2,15N
Entecavir- ¹³C₂, ¹⁵N (BMS200475- ¹³C₂, ¹⁵N; SQ34676- ¹³C₂, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Entecavir (HY-13623). Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC₅₀ of 3.75 nM in HepG2 cell.

HY-14914S1

Azilsartan-d4
Azilsartan-d₄ is the deuterium labeled Azilsartan[1]. Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research[2][3][4][5][6].

HY-B1826S2

Adefovir-d4
Adefovir-d₄ is the deuterium labeled Adefovir. Adefovir (GS-0393) is an adenosine monophosphate analog antiviral agent that after intracellular conversion to Adefovir diphosphate inhibits HBV DNA polymerase. Adefovir has an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir has good antiviral activity against several viruses, including HBV and herpesviruses[1][2][3].

HY-B0144S

Pitavastatin-d4 hemicalcium

Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

Cat. No.	Product Name		Classification

HY-162129

Antitumor agent-131		Azide
Antitumor agent-131 (Compound 2-p) is an ER fluorescent probe with an IC₅₀ value of 23 nM for HepG2 tumor cells. Antitumor agent-131 can be used as a photosensitizer for the study of cancer photodynamics .

Cat. No.	Product Name		Classification

HY-160059

JHIT2e aptamer sodium		Aptamers
JHIT2e aptamer sodium is a molecular probe based on the aptamer JHIT2 of human liver cancer cell line HepG2 cells. JHIT2e aptamer sodiu retains the ability to specifically bind HepG2 and can deliver fluorescent materials or radionuclides to tumors .

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