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Results for "

cns

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (25) AAK1 (2) Adenosine Receptor (4) Adenylate Cyclase (1) Adrenergic Receptor (9) Aldehyde Dehydrogenase (ALDH) (1) Amino acid Transporter (1) Amyloid-β (3) Anaplastic lymphoma kinase (ALK) (6) Angiotensin Receptor (1) Antibiotic (6) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (15) Aquaporin (3) Arginase (1) Atg8/LC3 (1) Autophagy (5) Bacterial (7) Bcl-2 Family (1) Beclin1 (1) Beta-secretase (3) Biochemical Assay Reagents (3) Bradykinin Receptor (1) c-Fms (2) c-Kit (1) Calcium Channel (10) Cannabinoid Receptor (4) Carbonic Anhydrase (1) Caspase (3) Cathepsin (1) CCR (1) CDK (2) Ceramidase (1) Cholecystokinin Receptor (5) Cholinesterase (ChE) (4) CMV (4) COMT (6) COX (2) CRAC Channel (1) CXCR (1) Cytochrome P450 (2) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (3) Dopamine Receptor (8) Dopamine Transporter (1) Drug Derivative (4) Drug Isomer (2) Drug Metabolite (4) DYRK (3) EGFR (4) Endogenous Metabolite (33) Epigenetic Reader Domain (1) ERK (2) Eukaryotic Initiation Factor (eIF) (2) FAAH (3) Fatty Acid Synthase (FASN) (1) Ferroptosis (3) Fungal (1) GABA Receptor (9) GCGR (3) GHSR (2) Glucosylceramide Synthase (GCS) (1) GlyT (2) GPR139 (1) GSK-3 (6) Guanylate Cyclase (1) HBV (6) HDAC (7) HIF/HIF Prolyl-Hydroxylase (2) Histamine Receptor (4) Histone Demethylase (1) HIV (9) HSV (4) iGluR (33) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (2) Integrin (3) Interleukin Related (3) IRAK (1) Isotope-Labeled Compounds (16) JNK (1) LDLR (1) LPL Receptor (3) LRRK2 (3) mAChR (7) MAGL (1) MAP3K (1) MARCKS (2) mGluR (16) MHC (1) Microtubule/Tubulin (4) MMP (1) Monoamine Oxidase (4) mTOR (2) Na+/K+ ATPase (1) nAChR (6) Neurokinin Receptor (10) Neuromedin U Receptor (NMUR) (1) Neuropeptide Y Receptor (2) NF-κB (1) NO Synthase (2) NOD-like Receptor (NLR) (2) Nucleoside Antimetabolite/Analog (4) OGA (1) Opioid Receptor (12) Orthopoxvirus (1) Oxytocin Receptor (4) P-glycoprotein (1) P2X Receptor (6) p38 MAPK (5) Parasite (3) PARP (1) PGE synthase (1) Phosphodiesterase (PDE) (9) Phospholipase (1) PI3K (2) PKC (1) Potassium Channel (6) Prostaglandin Receptor (1) Raf (2) Reactive Oxygen Species (1) Reference Standards (1) Reverse Transcriptase (6) ROCK (1) ROR (2) Serotonin Transporter (2) Sodium Channel (9) Somatostatin Receptor (2) Tau Protein (2) Thyroid Hormone Receptor (4) Topoisomerase (2) TRP Channel (5) Tyrosinase (1) Vasopressin Receptor (1) VDAC (1) VEGFR (3) Virus Protease (1) α-synuclein (1) γ-secretase (4)
By Research Areas:	Cancer (86) Cardiovascular Disease (17) Endocrinology (26) Infection (25) Inflammation/Immunology (42) Metabolic Disease (18) Neurological Disease (273)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Fillers (1) Antisense Oligonucleotides (2)

379

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156585

CNS-11	Tau Protein α-synuclein	Neurological Disease
CNS-11 is a blood-brain barrier permeable tau fibril-degrading compound. CNS-11 reduces α-synuclein. CNS-11 can be used in Alzheimer's and Parkinson's disease research .

HY-110097

Aptiganel hydrochloride cns 1102	iGluR	Neurological Disease
Aptiganel hydrochloride (Cerestat) is a non-competitive NMDA receptor antagonist with neuroprotective effect.

HY-N2321

Salsolinol-1-carboxylic acid 1 Publications Verification	Others	Neurological Disease
Salsolinol-1-carboxylic acid is an endogenous alkaloid in the central nervous system (CNS) .

HY-N5075

Quercetin 3-O-glucoside-7-O-rhamnoside	Others	Neurological Disease
Quercetin 3-O-glucoside-7-O-rhamnoside is a member of flavonoid glycosides group with an inhibitory activity on the CNS .

HY-101809A

CNS 5161	iGluR	Cardiovascular Disease
CNS-5161 is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.

HY-101809

CNS-5161 hydrochloride cns 5161A	iGluR	Cardiovascular Disease
CNS-5161 hydrochloride is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.

HY-100356

Aptiganel cns 1102 free base	iGluR	Neurological Disease
Aptiganel (CNS 1102 (free base)), peptide, is a noncompetitive NMDA antagonist with cerebroprotective effects. Aptiganel can be used for the research of stroke .

HY-167893

AGH-107	5-HT Receptor	Neurological Disease
AGH-107 is a high selective and brain-penetrant agonist of 5-HT7 receptor, with a K_i of 6 nM and EC₅₀ of 19 nM. AGH-107 exhibits high selectivity over related CNS targets, high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures .

HY-162232

mGluR2 agonist 1	mGluR	Neurological Disease
mGluR2 agonist 1 (Compound 5b) is a potent and selective metabotropic glutamate 2 receptor (mGluR) agonist with an EC₅₀ of 82 nM. mGluR2 agonist 1 can be used for the research of central nervous system (CNS) diseases .

HY-101281A

(Rac)-VU 6008667	mAChR	Neurological Disease
(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC₅₀=1.8 μM, pIC₅₀= 5.75), has high CNS penetration .

HY-118098

LY3202626	Beta-secretase	Neurological Disease
LY3202626 is a CNS penetrant BACE inhibitor with IC₅₀s of 0.615 nM and 0.871 nM against BACE1 and BACE2, respectively .

HY-144764

5-HT1A antagonist 1	5-HT Receptor	Neurological Disease
5-HT1A antagonist 1 (compound 6f) is a potent and selective antagonist of 5-HT_1A receptor, with a K_i of 35 nM. 5-HT1A antagonist 1 can be used for the research of CNS diseases .

HY-132981

Lu AF27139	P2X Receptor	Neurological Disease
Lu AF27139 is a potent, selective, and orally active antagonist of P2X7 receptor (IC₅₀s of 12 and 2.4 nM for human and rat, K_is of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 has rodent-active and CNS-penetrant character. Lu AF27139 has the potential for the research of CNS diseases .

HY-124382

AS1928370	TRP Channel	Neurological Disease
AS1928370 is a novel and central nervous system (CNS) penetrant TRPV1 antagonist and can prevent ligand-induced activation in vivo. AS1928370 is a promising agent for neuropathic pain treatment research .

HY-15722

SB-222200 3 Publications Verification	Neurokinin Receptor	Neurological Disease Endocrinology
SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant NK-3 receptor antagonist. SB-222200 is developed for central nervous system (CNS) disorders .

HY-107730

NPY5RA-972	Neuropeptide Y Receptor	Neurological Disease
NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor .

HY-122138

VU6010572	mGluR	Neurological Disease
VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC₅₀ of 245 nM. VU6010572 is highly CNS penetrant .

HY-110191

VU0469650	mGluR	Neurological Disease Cancer
VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu₁ receptor, with an IC₅₀ of 99 nM .

HY-B0250A

Lamivudine salicylate BCH-189 salicylate	HIV Reverse Transcriptase HBV	Infection Cancer
Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine salicylate can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-125692

L-740093	Cholecystokinin Receptor	Metabolic Disease
L-740093 is a potent cholecystokinin-B receptor antagonist. L-740093 has excellent central nervous system (CNS) penetration .

HY-133554

ASK1-IN-1	MAP3K p38 MAPK	Inflammation/Immunology
ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC₅₀=138 nM; Biochemical IC₅₀=21 nM) .

HY-101281

VU 6008667	mAChR	Neurological Disease
VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC₅₀s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration .

HY-139279

Zotizalkib TPX-0131	Anaplastic lymphoma kinase (ALK)	Cancer
Zotizalkib (TPX-0131) is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK (IC₅₀ of 1.4 nM) and ALK-resistant mutation, e.g. G1202R (IC₅₀ of 0.3 nM), L1196M (IC₅₀ of 0.3 nM). Zotizalkib has strong antitumor activities .

HY-109189

Rezivertinib 1 Publications Verification BPI-7711	EGFR	Cancer
Rezivertinib (BPI-7711) is an orally active, highly selective and irreversible third-generation EGFR tyrosine kinase inhibitor (TKI). Rezivertinib exhibits high potency against the common activation EGFR and the resistance T790M mutations. Rezivertinib has excellent central nervous system (CNS) penetration and has antitumor activity .

HY-P2457

rCRAMP (rat)	Bacterial	Infection Inflammation/Immunology
rCRAMP (rat) is the rat cathelin-related antimicrobial peptide. rCRAMP (rat) contributes to the antibacterial activity in rat brain peptide/protein extracts. rCRAMP (rat) is a potential key player in the innate immune system of rat CNS .

HY-118158

FAAH/MAGL-IN-4	FAAH	Neurological Disease
FAAH/MAGL-IN-4 (Compound 13) is a potent fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) inhibitor with IC₅₀s of 9.1 nM and 7.9 μM, respectively. FAAH/MAGL-IN-4 can be used for the research of pain and CNS disorders .

HY-10975

MK-0752 sodium	γ-secretase	Neurological Disease Cancer
MK-0752 sodium is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC₅₀ of 5 nM in human SH-SY5Y cells. MK-0752 sodium crosses the blood-brain barrier. MK-0752 sodium reduces newly generated CNS Aβ in vivo .

HY-10974

MK-0752 10+ Cited Publications	γ-secretase	Neurological Disease Cancer
MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC₅₀ of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo .

HY-147405

Tinlorafenib PF-07284890; ARRY-461	Raf ERK	Cancer
Tinlorafenib (PF-07284890) is the orally active inhibitor for BRAF and CRAF with IC₅₀s of 5.8 nM and 4.1 nM. Tinlorafenib (Compound 10) inhibits V600E mutated BRAF and V600K mutanted BRAF with IC₅₀s of 4.25 nM and 2.7 nM. Tinlorafenib can cross the blood brain barrier. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF-associated malignant and benign tumors of the CNS as well as extracranial malignancies .

HY-144372

TRPV1 antagonist 3	TRP Channel	Neurological Disease
TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist with an IC₅₀ of 2.66 nM against capsaicin. TRPV1 antagonist 3 is mode-selective, oral bioavailable (F = 60%) and CNS-penetrant .

HY-154957

mTOR inhibitor-11	mTOR	Neurological Disease
mTOR inhibitor-11 (Compound 9) is a brain-penetrant mTOR inhibitor (IC₅₀: 21 nM for pS6). mTOR inhibitor-11 also inhibits pCHK1 and PDE4D with IC₅₀s of 17.2 and 17.0 μM. mTOR inhibitor-11 can be used for research of CNS disease .

HY-144696

Dyrk1A/α-synuclein-IN-2	DYRK	Neurological Disease
Dyrk1A/α-synuclein-IN-2 (Compound b20) is a dual Dyrk1A and α-synuclein aggregation inhibitor with an IC₅₀ of 7.8 µM for α-synuclein. Dyrk1A/α-synuclein-IN-2 has high predictive CNS penetration and neuroprotective effect .

HY-147657

GABAA receptor modulator-2	GABA Receptor	Neurological Disease
GABAA receptor modulator-2 (Compound 20) is selective, orally active α5-GABA_AR negative allosteric modulator (NAM) with a K_i of 4.1 nM. GABAA receptor modulator-2 shows high-metabolic stability and good CNS safety .

HY-131068

BACE-1 inhibitor 2	Beta-secretase	Neurological Disease
BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC₅₀ of 1.5 nM in BACE-1 enzymatic assay .

HY-154958

mTOR inhibitor-12	mTOR	Neurological Disease
mTOR inhibitor-12 (Compound 11) is a selective brain penetrant mTOR inhibitor without genotoxicity risk. mTOR inhibitor-12 can be used for the research of CNS diseases .

HY-111263

NIAD-4	Amyloid-β	Neurological Disease
NIAD-4 is a fluorophore for optical imaging of amyloid-β (Aβ) in the central nervous system (CNS) for Alzheimer’s disease (AD). NIAD-4 binds to the same Aβ site with the binding affinity (K_i) of 10 nM .

HY-12776

GSK805 4 Publications Verification	ROR	Inflammation/Immunology
GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC₅₀ values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity .

HY-15043

ELN-441958	Bradykinin Receptor	Inflammation/Immunology Endocrinology
ELN-441958 is a potent, neutral, competitive and selective bradykinin B₁ receptor antagonist with a K_i of 0.26 nM against native human bradykinin B₁ receptor. ELN-441958 has high oral bioavailability, and has low CNS exposure in the mouse .

HY-146068

AEP-IN-1	Cathepsin	Neurological Disease
AEP-IN-1 (Compound 13e) is a CNS agent-like non-covalent inhibitor of asparagine endopeptidase (AEP), with the IC₅₀ of 89 nM. AEP-IN-1 can be used for the research of numerous neurological diseases such as Alzheimer’s disease (AD) .

HY-144695

Dyrk1A/α-synuclein-IN-1	DYRK	Neurological Disease
Dyrk1A/α-synuclein-IN-1 (Compound b1) is a dual Dyrk1A and α-synuclein aggregation inhibitor with IC₅₀ values of 177 nM and 10.5 µM, respectively. Dyrk1A/α-synuclein-IN-1 has high predictive CNS penetration and neuroprotective effect .

HY-131181

LEI-401 2 Publications Verification	Phospholipase	Neurological Disease
LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC₅₀ of 27 nM. LEI-401 modulates emotional behavior in mice .

HY-W105505

SAMe-1,4-Butanedisulfonate	Biochemical Assay Reagents	Neurological Disease Inflammation/Immunology
SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders .

HY-145695

Dual AChE-MAO B-IN-1	Cholinesterase (ChE) Monoamine Oxidase	Neurological Disease
Dual AChE-MAO B-IN-1 (compound 15) is an orally bioavailable CNS-permeant potent inhibitor of both human AChE (IC₅₀=550 nM) and MAO B (IC₅₀=8.2 nM). Dual AChE-MAO B-IN-1 behaves as a safe and metabolically stable neuroprotective agent, devoid of cytochrome liability .

HY-155079

DZD1516	EGFR	Cancer
DZD1516 is a potent and selective HER2 inhibitor (IC₅₀=0.56 nM) with good blood-brain permeability. DZD1516 exhibits antitumor activity in CNS and subcutaneous xenograft mouse models .

HY-124754

Navacaprant BTRX-335140; CYM-53093	Opioid Receptor	Neurological Disease Metabolic Disease
Navacaprant (BTRX-335140) is a selective and orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC₅₀ values of 0.8 nM, 110 nM, and 6500 nM, respectively. Navacaprant endows with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rats. Navacaprant distributes well into the CNS and can be used for the research of neuropathy .

HY-B0250

Lamivudine 5+ Cited Publications BCH-189	HIV Reverse Transcriptase HBV	Infection Cancer
Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-119974

Caracemide NSC-253272	DNA/RNA Synthesis Bacterial	Infection Cancer
Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide is a novel anticancer agent derived from a hydroxamic acid and has demonstrated to produce severe central nervous system (CNS) toxicity .

HY-18679

TC-N 22A	mGluR	Neurological Disease
TC-N 22A is a potent, selective, orally active and brain-permeable mGlu₄ PAM with an EC₅₀ of 9 nM in human mGlu₄-expressing BHK cells. TC-N 22A is less active (EC₅₀>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo .

HY-14905

Uridine triacetate Tri-O-acetyl uridine	Others	Neurological Disease
Uridine triacetate (Tri-O-acetyl uridine) is an orally active proagent of Uridine (HY-B1449). Uridine triacetate is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate is used for the research of 5-fluorouracil (5-FU) and capecitabine toxicity, or early-onset cardiac or central nervous system (CNS) .

HY-172118

CDKL5/GSK3-IN-1	GSK-3	Neurological Disease
CDKL5/GSK3-IN-1 (Compound 2) is a potent and selectivity chemical probe for CDKL5/GSK3.CDKL5/GSK3-IN-1 has potent inhibition of CDKL5 and GSK3α/β, with IC₅₀ values of 4.6, 24 and 9.5 nM for CDKL5, GSK3β and GSK3α, respectively, in the NanoBRET assay. CDKL5/GSK3-IN-1 can be used for the research of CNS diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2321

Salsolinol-1-carboxylic acid 1 Publications Verification	Structural Classification Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Endogenous metabolite	Others
Salsolinol-1-carboxylic acid is an endogenous alkaloid in the central nervous system (CNS) .

HY-N5075

Quercetin 3-O-glucoside-7-O-rhamnoside	Structural Classification Flavonoids Flavones Source classification Phenols Polyphenols Arabidopsis thaliana Plants Brassicaceae Saccharides Monosaccharides	Others
Quercetin 3-O-glucoside-7-O-rhamnoside is a member of flavonoid glycosides group with an inhibitory activity on the CNS .

HY-N8441

Neriifolin 17β-Neriifolin	Apocynaceae Structural Classification Classification of Application Fields Cardiacglycosides Cerbera manghas Linn. Source classification Plants Inflammation/Immunology Disease Research Fields Steroids	Atg8/LC3 Na+/K+ ATPase Apoptosis Beclin1
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na ⁺, K ⁺-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells ^[2.

HY-105231

Bryostatin 1 2 Publications Verification	Structural Classification Anti-inflammation/Immunoregulatory Neurological Disease Classification of Application Fields Marine natural products Source classification Other marine organisms Disease Research Infection Macrolide Antibiotics Animals Antibiotics Anticancer Inflammation/Immunology Disease Research Fields	PKC HIV Bacterial
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a potent and central nervous system (CNS)-permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with K_is of 8.07 nM and 0.45 nM, respectively. Bryostatin 1 has anti-cancer, anti-inflammatory, neuroprotective, anti-HIV-1 infection properties .

HY-P3960

(Glu2)-TRH	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	Thyroid Hormone Receptor Endogenous Metabolite
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

HY-N2428

N-(3-Methoxybenzyl)Palmitamide	Natural Products other families Source classification Plants	FAAH
N-(3-Methoxybenzyl)Palmitamide is a promising inhibitor of FAAH for the treatment of pain, inflammation and CNS degenerative disorders .

HY-B1473A

Serotonin 5+ Cited Publications 5-Hydroxytryptamine; 5-HT	Alkaloids Structural Classification Microorganisms Endogenous metabolite Indole Alkaloids	5-HT Receptor COMT Endogenous Metabolite
Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-N3295

Mesuaxanthone A	Structural Classification Flavonoids Mesua ferrea L. Source classification Plants Calophyllaceae Other Flavonoids	Others
Mesuaxanthone A is a xanthone with anti-inflammatory activities. Mesuaxanthone A shows typical CNS depressant effects .

HY-N3193

Neritaloside	Apocynaceae Natural Products Source classification Nerium indicum Mill. Plants	Others
Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect ^[2.

HY-N11451

Lacto-N-fucopentaose III LNFP-III	Structural Classification Polysaccharides Animals Source classification Saccharides	Arginase Aldehyde Dehydrogenase (ALDH) Indoleamine 2,3-Dioxygenase (IDO)
Lacto-N-fucopentaose III (LNFP-III) is an immune modulator. Lacto-N-fucopentaose III reduces the severity of experimental autoimmune encephalomyelitis (EAE) and CNS inflammation .

HY-B1473

Serotonin hydrochloride 5+ Cited Publications 5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride	Alkaloids Structural Classification Source classification Endogenous metabolite Indole Alkaloids	5-HT Receptor COMT Endogenous Metabolite
Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM.

HY-P0201

Substance P Maximum Cited Publications 20 Publications Verification Neurokinin P	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Neurokinin Receptor Endogenous Metabolite
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-N2072

Crocetin 1 Publications Verification Transcrocetin; trans-Crocetin	Structural Classification Classification of Application Fields Terpenoids Source classification Diterpenoids Lridaceae Plants Crocus sativus L. Endogenous metabolite Disease Research Fields Cancer	iGluR Endogenous Metabolite
Crocetin (Transcrocetin), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity . Crocetin is capable of crossing the blood-brain barrier and reach the central nervous system (CNS) .

HY-B0770

Artemotil 1 Publications Verification β-Arteether; (+)-Arteether; Arteether	Structural Classification Natural Products Classification of Application Fields Source classification Artemisia carvifolia Buch.-Ham. ex Roxb. Plants Compositae Disease Research Fields Cancer	CXCR Parasite
Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant *Plasmodium falciparum* malaria with an IC₅₀ of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys .

HY-N2072R

Crocetin (Standard)	Structural Classification Terpenoids Source classification Diterpenoids Lridaceae Plants Crocus sativus L. Endogenous metabolite	iGluR Endogenous Metabolite
Crocetin (Standard) is the analytical standard of Crocetin. This product is intended for research and analytical applications. Crocetin (Transcrocetin), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity . Crocetin is capable of crossing the blood-brain barrier and reach the central nervous system (CNS) .

HY-122381

Kyotorphin	Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields	Bacterial Endogenous Metabolite
Kyotorphin is an endogenou neuroactive dipeptide with analgesic properties. Kyotorphin possesses anti-inflammatory and antimicrobial activity. Kyotorphin levels in cerebro-spinal fluid correlate negatively with the progression of neurodegeneration in Alzheimer's Disease patients .

HY-Y0966

Glycine 5+ Cited Publications	Structural Classification Neurological Disease Classification of Application Fields Source classification Amino acids Endogenous metabolite Disease Research Fields	Endogenous Metabolite iGluR VEGFR
Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis .

HY-167825

Barakol	Seeds of Cassia tora Linn. Structural Classification Natural Products Leguminosae Source classification Plants	MMP Apoptosis Bcl-2 Family Reactive Oxygen Species
Barakol is a major compound found in Cassia siamea. Barakol inhibits MMP-3 activity. Barakol potentiates the anti-metastatic effect of Doxorubicin (HY-15142). Barakol induces apoptosis, with ROS generation, increase in expression ratio of Bax/Bcl-2, and caspase-9 activation. Barakol has laxative, anxiolytic, CNS depressant, and antioxidant, anticancer effects .

HY-Y0966R

Glycine (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Endogenous metabolite Cancer	Endogenous Metabolite iGluR VEGFR
Glycine (Standard) is the analytical standard of Glycine. This product is intended for research and analytical applications. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is orally active. Glycine can be used to study cell protection, cancer, neurological diseases, and angiogenesis .

HY-N7814R

2-Hydroxypalmitic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Endogenous Metabolite
Pheniramine (maleate) (Standard) is the analytical standard of Pheniramine (maleate). This product is intended for research and analytical applications. Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects .

HY-N0067R

γ-Aminobutyric acid (Standard) 3 Publications Verification 4-Aminobutyric acid (Standard)	Structural Classification Animals Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite GABA Receptor
γ-Aminobutyric acid (Standard) is the analytical standard of γ-Aminobutyric acid. This product is intended for research and analytical applications. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system .

HY-N0067

γ-Aminobutyric acid 3 Publications Verification 4-Aminobutyric acid	Structural Classification Animals Ketones, Aldehydes, Acids Endogenous metabolite	GABA Receptor Endogenous Metabolite
γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABA_A receptors) and metabotropic receptors (GABA_B receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system .

Cat. No.	Product Name	Chemical Structure

HY-B1473AS

Serotonin-d4
Serotonin-d₄ is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.

HY-Y0966S8

Glycine-d5
Glycine-d₅ is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-B0194S

Tizanidine-d4
Tizanidine-d₄ is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons[1][2].

HY-Y0966S1

Glycine-d2
Glycine-d₂ is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S3

Glycine-13C2
Glycine- ¹³C₂ is the ¹³C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S2

Glycine-2-13C
Glycine-2- ¹³C is the ¹³C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S4

Glycine-1-13C
Glycine-1- ¹³C is the ¹³C-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-B0250S

Lamivudine-15N,d2
Lamivudine- ¹⁵N,d₂ is ¹⁵N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-B0740S

Cyclobenzaprine-d3 hydrochloride
Cyclobenzaprine-d₃ (hydrochloride) is the deuterium labeled Cyclobenzaprine hydrochloride. Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

HY-Y0966S10

Glycine-d3
Glycine-d₃ is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S

Glycine-15N
Glycine- ¹⁵N is the ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[1].

HY-Y0966S9

Glycine-15N,d2
Glycine- ¹⁵N,d₂ is the deuterium and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S6

Glycine-13C2,15N
Glycine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S7

Glycine-2-13C,15N
Glycine-2- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-Y0966S5

Glycine-1-13C,15N
Glycine-1- ¹³C, ¹⁵N is the ¹³C- and ¹⁵N-labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

HY-B1473S1

Serotonin-13C2,15N hydrochloride
Serotonin- ¹³C₂, ¹⁵N hydrochloride is the ¹³C- and ¹⁵N-labeled Serotonin hydrochloride (HY-B1473). Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-B1473S

Serotonin-d4 hydrochloride
Serotonin-d₄ (5-Hydroxytryptamine-d₄) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473) . Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a K_i of 44 μM .

HY-Y0966S11

Glycine-13C2,15N,d2
Glycine- ¹³C₂, ¹⁵N,d₂ is the deuterium, ¹³C and ¹⁵N labeled Glycine[1]. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors[2].

HY-B0250S2

Lamivudine-13C,15N3
Lamivudine- ¹³C, ¹⁵N₃ (BCH-189- ¹³C, ¹⁵N₃) is ¹³C and ¹⁵N labeled Lamivudine. Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS .

HY-13011S1

Alectinib-d6
Alectinib-d₆ is deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].

HY-13011S

Alectinib-d8
Alectinib-d₈ is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].

HY-W739056

SAMe-1,4-Butanedisulfonate-d3
SAMe-1,4-Butanedisulfonate-d₃ is the deuterium labeled SAMe-1,4-Butanedisulfonate (HY-W105505). SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders

HY-12650S

Mirogabalin-13C2,d1 (Mixture of Diastereomers)
Mirogabalin-13C2,d1 (Mixture of Diastereomers) is a C13 and deuterium labeled Mirogabalin. Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS .

HY-B0250S1

Lamivudine-13C,15N2,d2
Lamivudine-13C,15N2,d2 (BCH-189-13C,15N2,d2) is a 13C, 15N, and deuterium labeled Lamivudine (HY-B0250). Lamivudine is an orally active and blood-brain barrier permeable nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus (HBV) reverse transcriptase .

HY-B0653AS

Levobupivacaine-d9 hydrochloride

Levobupivacaine-d₉ ((S)-(–)-Bupivacaie-d₉) hydrochloride is deuterium labeled Levobupivacaine (hydrochloride). Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a long-acting amide local agent that can suppress or relieve pain. Levobupivacaine hydrochloride exerts agent that can suppress or relieve pain. and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine hydrochloride can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine hydrochloride is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine hydrochloride can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer .

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