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Results for "

LIGHT

" in MedChemExpress (MCE) Product Catalog:

487

Inhibitors & Agonists

1

Screening Libraries

69

Fluorescent Dye

22

Biochemical Assay Reagents

23

Peptides

1

MCE Kits

216

Inhibitory Antibodies

31

Natural
Products

30

Recombinant Proteins

4

Isotope-Labeled Compounds

23

Antibodies

3

Click Chemistry

12

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126367
    Light green SF yellowish
    1 Publications Verification

    Acid Green 5

    		 Fluorescent Dye Others
    Light green SF yellowish (Acid Green 5) is a triarylmethane dye. Light green SF yellowish is a highly selective mitochondrial stain. Light green SF yellowish is usually available as a disodium salt and has a maximum absorption value as 629 nm. Light green SF yellowish can be used as a histological stain for collagen and a critical component of Papanicolaou stains .
    Light green SF yellowish
  • HY-B1556
    Benzyl salicylate

    NSC 6647

    		 Drug Derivative JNK ERK p38 MAPK Apoptosis Others
    Benzyl salicylate is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber.
    Benzyl salicylate
  • HY-P99481
    Birtamimab

    NEOD001

    		 Amyloid-β Neurological Disease
    Birtamimab (NEOD001) is an investigational monoclonal antibody that specifically and selectively target and clear the amyloid. Birtamimab can be used for the research of light chain amyloidosis .
    Birtamimab
  • HY-126789
    DM-Nitrophen

    		Biochemical Assay Reagents Others
    DM-Nitrophen is a Ca 2+ cage. DM-Nitrophen releases Ca 2+ when cleaved upon illumination with near-ultraviolet light .
    DM-Nitrophen
  • HY-154636A
    Light Liquid Paraffin

    		Biochemical Assay Reagents Others
    Light Liquid Paraffin can be used as an excipient, such as excipient, lubricant. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs .
    Light Liquid Paraffin
  • HY-D2754
    BP Light 550 carboxylic acid

    		Fluorescent Dye Others
    BP Light 550 acid is a vibrant orange-to-red fluorochrome with better performance t han other rhodamine derivatives, including BP Fluor 555, TRITC, and Cy3 dye for fluorescent applications. The high water solubility of BP Light Fluors means that a high dye-to-protein ratio can be attained without causing precipitation of the conjugates.
    BP Light 550 carboxylic acid
  • HY-D2736
    BP Light 800 NHS ester

    		Fluorescent Dye Others
    BP Light 800 NHS ester is an amine reactive hydrophilic fluorochrome . It can be conjugated to antibody with higher D/P ratio and widely used applications including western blotting, microscopy, flow cytometry, and cell based assays.
    BP Light 800 NHS ester
  • HY-P5998
    Myosin Light Chain Kinase Substrate (smooth muscle)

    		Myosin Cancer
    Myosin Light Chain Kinase Substrate (smooth muscle) is a smooth muscle myosin light chain kinase (MLCK) synthetic peptide substrate .
    Myosin Light Chain Kinase Substrate (smooth muscle)
  • HY-D2755
    BP Light 650 carboxylic acid

    		Fluorescent Dye Others
    BP Light 650 carboxylic acid is an vibrant far-red fluorochrome with comparable or improved performance over other dyes, including BP Fluor 647 and Cy5 dye, for fluorescent applications. It is used to label antibodies and other proteins as molecular probes for cellular imaging and other fluorescence detection methods application.
    BP Light 650 carboxylic acid
  • HY-P10346
    smMLCK peptide

    Smooth-Muscle Myosin LIGHT-Chain Kinase (796-815)

    		 Myosin Cardiovascular Disease Inflammation/Immunology
    smMLCK peptide is a specific inhibitor of smooth muscle myosin light chain kinase (smMLCK). The smMLCK peptide mimics the substrate and competitively inhibits the binding of the actual substrate to the enzyme, thereby inhibiting the kinase activity. This inhibition prevents the phosphorylation of the myosin light chain, thus inhibiting muscle contraction .
    smMLCK peptide
  • HY-131551
    Drometrizole

    		Biochemical Assay Reagents Others
    Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies .
    Drometrizole
  • HY-145890
    LC kinetic stabilizer-2

    		Amyloid-β Inflammation/Immunology
    LC kinetic stabilizer-2 is a potent  amyloidogenic immunoglobulin light chain (LC) kinetic stabilizer with an EC50 of 24 nM .
    LC kinetic stabilizer-2
  • HY-B1556R
    Benzyl salicylate (Standard)

    		Others Others
    Benzyl salicylate (Standard) is the analytical standard of Benzyl salicylate. This product is intended for research and analytical applications. Benzyl salicylate?is a salicylic acid benzyl ester. It can be used as a fragrance additive or UV light absorber.
    Benzyl salicylate (Standard)
  • HY-131551R
    Drometrizole (Standard)

    		Biochemical Assay Reagents Others
    Drometrizole (Standard) is the analytical standard of Drometrizole. This product is intended for research and analytical applications. Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies .
    Drometrizole (Standard)
  • HY-126913
    Rhodblock 6

    		ROCK Cancer
    Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits phospho-MRLC (myosin regulatory light chain) localization .
    Rhodblock 6
  • HY-148851
    Bacteriochlorophyll a, from Rhodopseudomonas sphaeroides (under argon)

    BChl a, from Rhodopseudomonas sphaeroides (under argon)

    		 Bacterial Others
    Bacteriochlorophyll a, from Rhodopseudomonas sphaeroides (under argon) (BChl a, from Rhodopseudomonas sphaeroides (under argon)) is a chlorophyll analog found in some bacteria that participates in the light absorption and energy transfer processes of photosynthesis .
    Bacteriochlorophyll a, from Rhodopseudomonas sphaeroides (under argon)
  • HY-131019
    JF-NP-26

    		mGluR Neurological Disease
    JF-NP-26, an inactive photocaged derivative of raseglurant, is the first caged mGlu5 receptor negative allosteric modulator. Uncaging of JF-NP-26 is elicited with light pulses in the visible spectrum (405 nm). JF-NP-26 induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals .
    JF-NP-26
  • HY-D1416
    HMBR

    		Fluorescent Dye Others
    HMBR is an analogue with an additional methyl group on the aromatic ring and is non-fluorescent. HMBR conjugated with Y-FAST emits yellow fluorescence under blue light excitation (Ex= 419 nm; Em= 525–539 nm). HMBR is non-toxic to zebrafish embryos. HMBR has high cell permeability .
    HMBR
  • HY-B0754A
    Hematoporphyrin dihydrochloride
    10+ Cited Publications

    Hematoporphyrin IX dihydrochloride

    		 Apoptosis Endogenous Metabolite Cancer
    Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin dihydrochloride can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .
    Hematoporphyrin dihydrochloride
  • HY-B0754
    Hematoporphyrin

    Hematoporphyrin IX

    		 Apoptosis Endogenous Metabolite Cancer
    Hematoporphyrin (Hematoporphyrin IX), a photosensitizer, is a substrate for affinity chromatography of heme-binding proteins. Hematoporphyrin can induce apoptosis in U87 glioma cells and decrease tumor growth in vivo when exposed to red light .
    Hematoporphyrin
  • HY-119994
    DFPM

    		Protein Arginine Deiminase Others
    DFPM activates plant resistance protein signaling in roots, and triggers root growth arrest. DFPM decreases root cell viability in accession Col-0. DFPM is light sensitive in aqueous solutions. DFPM becomes bioactive during light and oxygen-dependent modification .
    DFPM
  • HY-161092
    KIO-301 chloride

    		HCN Channel Potassium Channel Neurological Disease
    KIO-301 chloride is an azobenzene photoswitch compound that can block voltage-gated ion channels, including hyperpolarisation-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium channels during exposure to visible light .
    KIO-301 chloride
  • HY-126789A
    DM-Nitrophen tertasodium

    		Biochemical Assay Reagents Others
    DM-Nitrophen tertasodium is a Ca 2+ cage. DM-Nitrophen releases Ca 2+ when cleaved upon illumination with near-ultraviolet light . DM-Nitrophen tertasodium can be used for study of Ca 2+ signaling .
    DM-Nitrophen tertasodium
  • HY-161092A
    KIO-301 chloride (hydrochloride)

    		HCN Channel Potassium Channel Others
    KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels) .
    KIO-301 chloride (hydrochloride)
  • HY-161650
    PROTAC BRD4 Degrader-26

    		PROTACs Epigenetic Reader Domain Cancer
    PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC, which degrades 80% BRD4 at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 (HY-161651); Black: linker (HY-161653); Blue: E3 ligase ligand Thalidomide 4-fluoride (HY-41547))
    PROTAC BRD4 Degrader-26
  • HY-P99810
    Quisovalimab

    AVTX-002; AEVI 002; SAR 252067

    		 SARS-CoV Cardiovascular Disease
    Quisovalimab (AVTX-002; AEVI 002; SAR 252067) is a human monoclonal antibody against LIGHT, a tumor necrosis factor (TNF)-related cytokine (TNFSF14) that plays an important role in acute respiratory distress syndrome (ARDS) and cytokine release syndrome (CRS) COVID-19. Quisovalimab can be used in COVID-19 acute respiratory distress syndrome and other studies .
    Quisovalimab
  • HY-145889
    LC kinetic stabilizer-1

    		Biochemical Assay Reagents Others
    LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL * and WIL-FL * T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer .
    LC kinetic stabilizer-1
  • HY-P990785
    Etentamig

    ABBV-383; TNB 383B

    		 CD3 Cardiovascular Disease Inflammation/Immunology Cancer
    Etentamig is a BCMA × CD3 bispecific T-cell engager (BiTE) that can inhibit the activity of B-cell maturation antigen (BCMA) and activate the T-cell surface glycoprotein CD3 complex. Etentamig can be used for research in multiple myeloma, immunoglobulin light chain amyloidosis, and cardiovascular diseases .
    Etentamig
  • HY-P10628
    β Amyloid (1-14), human

    		Amyloid-β Neurological Disease
    β Amyloid (1-14), human is a peptide fragment of β-amyloid protein (Aβ), which is obtained by hydrolysis of Aβ1-40 peptide by catalytic antibody light chain #7TR. β Amyloid (1-14), human can be used for Alzheimer's disease research .
    β Amyloid (1-14), human
  • HY-116420
    ROCK2-IN-8

    		ROCK Neurological Disease
    ROCK2-IN-8 (Compound 1) is an orally active ROCK2 inhibitor, with an IC50 of 7.2 nM. ROCK2-IN-8 can be used for the research of aqueous humor outflow in porcine eyes and myosin light chain phosphorylation .
    ROCK2-IN-8
  • HY-155996
    FD2157

    		PI3K Apoptosis Cancer
    FD2157 is a photosensitive PI3K inhibitor, with IC50s of 43 nM, 83 nM, 84 nM, 14 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ respectively. FD2157 potently inhibits cancer cell proliferation and induces cell apoptosis when exposed to 365 nm UV light .
    FD2157
  • HY-112841
    PTZ-343

    3-(10′-Phenothiazinyl)propane-1-sulfonate sodium; SPTZ sodium

    		 Fluorescent Dye Cancer
    PTZ-343 is a potent enhancer of Luminol (HY-15922). PTZ-343 greatly increases the light output of the peroxidase-catalyzed luminol chemiluminescent oxidation reaction (>80%) .
    PTZ-343
  • HY-100912
    W-7 hydrochloride
    5 Publications Verification

    		 Phosphodiesterase (PDE) Myosin Apoptosis Calmodulin Cancer
    W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca 2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively . W-7 hydrochloride induces apoptosis and has antitumor activity .
    W-7 hydrochloride
  • HY-110211
    BODIPY TMR-X SE

    		Fluorescent Dye Others
    BODIPY TMR-X SE is a potent fluorescent dye. BODIPY TMR-X SE can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, orange fluorescent light. (λex=544 nm, λem=570 nm) .
    BODIPY TMR-X SE
  • HY-110212
    BODIPY TR-X

    BODIPY TR-X NHS Ester

    		 Fluorescent Dye Others
    BODIPY TR-X (BODIPY TR-X NHS Ester) is a potent fluorescent dye. BODIPY TR-X can be used to label the primary amines (R-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. BODIPY TR-X binds to protein or antibody and has bright, red fluorescent light. (λex=545 nm, λem=560 nm) .
    BODIPY TR-X
  • HY-W750459
    Fluorescent brightener 28 (Technical Grade)

    		Fluorescent Dye Others
    Fluorescent brightener 28 (Technical Grade) is a fluorescent whitening agent commonly used in the padding process of the textile industry. Fluorescent brightener 28 is capable of staining polysaccharides such as cellulose, and when the plasma membrane ruptures, it also weakly stains the cytoplasm and strongly stains the cell nucleus. Additionally, Fluorescent brightener 28 can be utilized to detect intracellular chitin in living cells. Fluorescent Brightener 28 also is a visible light emitting diode (LED)-light sensitive photoinitiator for free radical photopolymerizations .
    Fluorescent brightener 28 (Technical Grade)
  • HY-D0367
    Fluorescent Brightener 28 (25% in water)

    Calcofluor White M2R

    		 Fluorescent Dye Others
    Fluorescent brightener 28 is a fluorescent whitening agent commonly used in the padding process of the textile industry. Fluorescent brightener 28 is capable of staining polysaccharides such as cellulose, and when the plasma membrane ruptures, it also weakly stains the cytoplasm and strongly stains the cell nucleus. Additionally, Fluorescent brightener 28 can be utilized to detect intracellular chitin in living cells. Fluorescent Brightener 28 also is a visible light emitting diode (LED)-light sensitive photoinitiator for free radical photopolymerizations .
    Fluorescent Brightener 28 (25% in water)
  • HY-124717
    YC-001

    		Endogenous Metabolite Others
    YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration .
    YC-001
  • HY-125667
    PA1

    Photoamiloride-1

    		 Sodium Channel Metabolic Disease
    PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively .
    PA1
  • HY-100224
    SANT-1
    3 Publications Verification

    		 Smo Hedgehog Cancer
    SANT-1, a potent Smo antagonist, inhibits Hedgehog signaling. SANT-1 shows IC50s of 20 nM and 30 nM in Shh-LIGHT2 and SmoA1-LIGHT2 assay, respectively .
    SANT-1
  • HY-P99325
    Toralizumab

    IDEC-131; Anti-Human CD40 ligand Recombinant Antibody

    		 TNF Receptor Inflammation/Immunology
    Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab, a immunosuppressive agent, has the potential for active systemic lupus erythematosus (SLE) research .
    Toralizumab
  • HY-P2162
    Kemptamide

    		Myosin Cancer
    Kemptamide, a 13 amino acid fragment with a sequence corresponding to residues 11-23 of gizzard light chain. Kemptamide is a peptide substrate of myosin light-chain kinase (MLCK) .
    Kemptamide
  • HY-D0823
    CY3-SE

    Sulfo-Cy3 NHS ester; Sulfo Cyanine3 NHS ester

    		 Fluorescent Dye Others
    Storage: protect from light.
    CY3-SE
  • HY-D1815
    Allophycocyanin

    APC Dye

    		 Fluorescent Dye Others
    Allophycocyanin (APC Dye) is a light-harvesting protein, containing strongly coupled dimers of chromophores. Allophycocyanin serve as a minimal system to examine photosynthetic energy transfer. Allophycocyanin strongly absorbs far-red light (FRL), and expresses during acclimation to low light, likely associates with chlorophyll a-containing photosystem I .
    Allophycocyanin
  • HY-169740
    L-Luciferin

    		Fluorescent Dye Others
    L-Luciferin is a competitive inhibitor of firefly Luciferin and can be used as an alternative substrate for light production, increasing the concentration of the enzyme or L-luciferin reduces the amount of light produced compared to D-Luciferin catalysis .
    L-Luciferin
  • HY-161652
    Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione is the conjugate of a linker and a ligand for E3 ligase. Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione can be used for synthesis of PROTAC BRD4 Degrader-26 (HY-161650) .
    Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione
  • HY-161093
    PROTAC BRD4 Degrader-23

    		PROTACs Cancer
    PROTAC BRD4 Degrader-23 (compound 17) is an effective visible-light-controlled degrader. PROTAC BRD4 Degrader-23 can inhibit tumor cell proliferation under 405 nm light irradiation .
    PROTAC BRD4 Degrader-23
  • HY-D0012A
    Bromothymol Blue sodium

    		Biochemical Assay Reagents Others
    Bromothymol Blue sodium salt is a pH indicator. Storage: protect from light.
    Bromothymol Blue sodium
  • HY-161897
    CENP-E-IN-2

    		Kinesin Cancer
    CENP-E-IN-2 (compound 3) is a photoswitchable CENP-E inhibitor, with the pIC50 of 6.82 without light illumination and 5.85 with 365 nm light illumination. CENP-E-IN-2 has antitumor activity .
    CENP-E-IN-2
  • HY-P1004A
    Luciferase, firefly

    		Fluorescent Dye Others
    Luciferase, firefly is the light-emitting enzyme responsible for the bioluminescence of fireflies and click beetles.
    Luciferase, firefly

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