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Type II

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (1) 5 alpha Reductase (5) Adenylate Cyclase (1) Adrenergic Receptor (1) Akt (6) AMPK (4) Amylases (2) Amylin Receptor (2) Androgen Receptor (4) Angiotensin Receptor (54) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (20) AP-1 (6) Apelin Receptor (APJ) (2) Apoptosis (43) Arrestin (3) Autophagy (21) Bacterial (25) Bcr-Abl (7) Biochemical Assay Reagents (13) BMX Kinase (1) c-Fms (3) c-Kit (3) c-Met/HGFR (1) Calcium Channel (6) CaMK (3) Carbonic Anhydrase (2) Caspase (6) CD20 (1) CD28 (1) CDK (4) CRFR (3) Cytochrome P450 (2) Dipeptidyl Peptidase (2) Discoidin Domain Receptor (1) DNA/RNA Synthesis (3) Drug Metabolite (4) Endogenous Metabolite (12) Estrogen Receptor/ERR (2) Ferroptosis (1) FGFR (1) FLT3 (5) Fluorescent Dye (1) Free Fatty Acid Receptor (8) Fungal (3) GCGR (1) GLP Receptor (4) Glycosidase (5) GnRH Receptor (2) GSK-3 (2) HBV (1) HCV (1) HDAC (1) HIV (1) HSV (1) Interleukin Related (3) IPK Superfamily (1) IRAK (1) Isotope-Labeled Compounds (15) JAK (3) JNK (6) Ligands for Target Protein for PROTAC (3) Liposome (3) Lipoxygenase (1) LRRK2 (1) MAGL (1) MEK (3) Melanocortin Receptor (1) mGluR (2) MHC (4) Mineralocorticoid Receptor (2) Mitochondrial Metabolism (2) MMP (12) nAChR (1) Neprilysin (2) NF-κB (7) Nuclear Hormone Receptor 4A/NR4A (1) p38 MAPK (2) p97 (1) PACAP Receptor (4) Parasite (8) PDGFR (4) Phosphatase (1) Phosphodiesterase (PDE) (1) PI3K (6) PKA (5) PKC (2) PKG (1) Potassium Channel (1) PPAR (5) Prostaglandin Receptor (2) Raf (2) Ras (1) Reactive Oxygen Species (13) RET (2) RIP kinase (3) SARS-CoV (1) Ser/Thr Protease (3) SGLT (1) Sodium Channel (6) Src (1) Stearoyl-CoA Desaturase (SCD) (1) STING (1) TAM Receptor (1) TGF-beta/Smad (2) TGF-β Receptor (7) Thyroid Hormone Receptor (2) TNF Receptor (1) Topoisomerase (23) Trk Receptor (6) TrxR (1) VEGFR (2) Xanthine Oxidase (1)
By Research Areas:	Cancer (95) Cardiovascular Disease (56) Endocrinology (40) Infection (38) Inflammation/Immunology (46) Metabolic Disease (76) Neurological Disease (33)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pegylated Lipids (1) Liposomal Film-forming Agents (1) Emulsifiers (1)

288

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Photosystem II C-type Lectin-like Receptors (CTLRs) Scavenger Receptor Class B type I (SR-BI） PCSK9 CD74

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70005B

*Collagenase, Type* II** 2 Publications Verification	MMP	Others
Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-NP133A

*NP-KLH,Type* II** 4-Hydroxy-3-nitrophenylacetyl-Keyhole Limpet Hemocyanin,Type II	Biochemical Assay Reagents	Inflammation/Immunology
NP-KLH,Type II (4-Hydroxy-3-nitrophenylacetyl-Keyhole Limpet Hemocyanin,Type II) is a 4-Hydroxy-3-nitrophenylacetyl (NP) hapten. NP-KLH,Type II can be used for study as a carrier protein in immunological research .

HY-NP102

*Highly purified Type* II collagen, from bovine articular cartilage** Bovine Type II collagen, immunization grade	Biochemical Assay Reagents	Inflammation/Immunology
Highly purified Type II collagen, from bovine articular cartilage (Bovine Type II collagen, immunization grade), an immunization grade, is the major matrix protein in cartilage that can be used for the study of arthritis .

HY-150044

Type II topoisomerase inhibitor 1	DNA/RNA Synthesis Topoisomerase Bacterial	Infection
Type II topoisomerase inhibitor 1 is a potent and selective E. coli DNA gyrase inhibitor (IC₅₀: 1.7 nM), and forms hydrogen bonds with Asp73 residue. Type II topoisomerase inhibitor 1 inhibits topoisomerase IV activity (IC₅₀: 0.98 μM). Type II topoisomerase inhibitor 1 can be used in the research of antibacterial area .

HY-163004

Type II TRK inhibitor 2	Trk Receptor	Cancer
Type II TRK inhibitor 2 (compound 40l) is a selective type II TRK inhibitor with plasma stability and moderate hepatic microsomal stability. Type II TRK inhibitor 2 significantly inhibits Km-12, Ba/F3-TRKA ^G595R and Ba/F3-TRKA ^G667C cell proliferation (IC₅₀: 4.1 nM, 41.5 nM, 1.4 nM). Type II TRK inhibitor 2 can be used to study NTRK fusion cancers .

HY-146807

Type II TRK inhibitor 1	Trk Receptor	Cancer
Type II TRK inhibitor 1 is a potent TRK inhibitor, which inhibits various TRK fusion protein variants and wild type. Type II TRK inhibitor 1 exhibits antiproliferative activity against Ba/F3 cells harboring CD74-TRKA ^G667C and ETV6-TRKC ^G696C fusion proteins with IC₅₀s of 6 nM and 1.7 nM, respectively . Type II TRK inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-P5003

*Collagen Type* II Fragment**	MMP	Inflammation/Immunology
Collagen Type II Fragment is an anti-inflammatory peptide that potently inhibits collagen-induced arthritis (CIA) in mice. Collagen Type II Fragment can be used for research on inflammation and immunity .

HY-P10597

*Angiotensin II type* 1 receptor (181-187)**	Angiotensin Receptor	Others
Angiotensin II type 1 receptor (181-187) is a 9-amino acid sequence of the second extracellular loop of angiotensin II (Ang II) in the renin-angiotensin system. Angiotensin II type 1 receptor (181-187) serves as the localization epitope of angiotensin II receptor autoantibodies (AT1RaAb) and is used to detect and quantify AT1RaAb levels in serum .

HY-114632

Oxeglitazar	PPAR	Metabolic Disease
Oxeglitazar is an orally active compound that can be used for the research of type II diabetes .

HY-NP123

*Highly purified Type* II collagen, from porcine articular cartilage** Porcine Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type II collagen, from porcine articular cartilage (Porcine Type II collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP113

*Highly purified Type* II collagen, from chick sternal cartilage** Chick Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type II collagen, from chick sternal cartilage (Chick Type II collagen, immunization grade) is an immune grade collagen derived from chick sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP108

*Highly purified type* II collagen, from rat sternal cartilage** Rat Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified type II collagen, from rat sternal cartilage (Rat Type II collagen, immunization grade) is an immune grade collagen derived from rat sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP110

*Highly purified Type* II collagen, from mouse sternal cartilage** Mouse Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type II collagen, from mouse sternal cartilage (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP129

*Highly purified Type* II collagen, from sheep articular cartilage** Sheep Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type II collagen, from sheep articular cartilage (Sheep Type II collagen, immunization grade) is an immune grade collagen derived from sheep articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP130

*Highly purified Type* II collagen, from goat articular cartilage** Goat Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type II collagen, from goat articular cartilage (Goat Type II collagen, immunization grade) is an immune grade collagen derived from goat articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP117

*Highly purified Type* II collagen, from human sternal cartilage** Human Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type II collagen, from human sternal cartilage (Human Type II collagen, immunization grade) is an immune grade collagen derived from human sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-A0104J

*HPMC (Type* II,Viscosity:5mPa.s)** Hypromellose (Type II,Viscosity:5mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:5mPa.s); Celacol HPM 5000 (Type II,Viscosity:5mPa.s)	Biochemical Assay Reagents	Others
HPMC (Hypromellose) (Type II,Viscosity:5mPa.s) is a hydrophilic, non-ionic cellulose ether used to form swellable-soluble matrices. HPMC (Type II,Viscosity:5mPa.s) is widely used in agent formulations due to its biocompatibility, uncharged nature, solubility in water and thermoplastic behavior .

HY-A0104K

*HPMC (Type* II,Viscosity:3mPa.s)** Hypromellose (Type II,Viscosity:3mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:3mPa.s); Celacol HPM 5000 (Type II,Viscosity:3mPa.s)	Biochemical Assay Reagents	Others
HPMC (Type II,Viscosity:3mPa.s) is a derivative of Cellulose (HY-B2221), which forms pH-stable transparent colloidal solution in water. HPMC (Type II,Viscosity:3mPa.s) contains no ionized group, and exhibits good thermoplasticity, viscosity, biocompatibility and biodegradability, that can be used as stabilizer, thickener, and emulsifier in medicine, food, coatings, adhesives and construction industries .

HY-A0104I

*HPMC (Type* II,Viscosity:100000mPa.s)** Hypromellose (Type II,Viscosity:100000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:100000mPa.s); Celacol HPM 5000 (Type II,Viscosity:100000mPa.s)	Biochemical Assay Reagents	Others
Hydroxypropylmethylcellulose (Type II,Viscosity:100000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104E

*HPMC (Type* II,Viscosity:100mPa.s)** Hypromellose (Type II,Viscosity:100mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:100mPa.s); Celacol HPM 5000 (Type II,Viscosity:100mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:100mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104H

*HPMC (Type* II,Viscosity:15000mPa.s)** Hypromellose (Type II,Viscosity:15000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:15000mPa.s); Celacol HPM 5000 (Type II,Viscosity:15000mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:15000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104F

*HPMC (Type* II,Viscosity:400mPa.s)** Hypromellose (Type II,Viscosity:400mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:400mPa.s); Celacol HPM 5000 (Type II,Viscosity:400mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:400mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-A0104G

*HPMC (Type* II,Viscosity:4000mPa.s)** Hypromellose (Type II,Viscosity:4000mPa.s); (Hydroxypropyl)methyl cellulose (Type II,Viscosity:4000mPa.s); Celacol HPM 5000 (Type II,Viscosity:4000mPa.s)	Biochemical Assay Reagents	Others
Hypromellose (Type II,Viscosity:4000mPa.s) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-19859

AMG-222 tosylate	Dipeptidyl Peptidase	Metabolic Disease
AMG-222 (tosylate) is a DPP-IV inhibitor that can be used in the research of type II diabete .

HY-161057

HG-7-86-01	Bcr-Abl	Inflammation/Immunology Cancer
HG-7-86-01 (Compound 26) is type II tyrosine kinase inhibitor. HG-7-86-01 has anti-proliferative activity .

HY-P9910

Obinutuzumab GA101; Anti-Human CD20 Type II, Humanized Antibody	CD20	Cancer
Obinutuzumab (GA101) a novel glycoengineered Type II CD20 humanized IgG1 monoclonal antibody in development for non-Hodgkin lymphoma.

HY-105010

FK-739 free base	Angiotensin Receptor	Cardiovascular Disease
FK-739 (free base) is an angiotensin II type 1 (AT1) receptor antagonist used in the study of hypertension .

HY-120886

GW 2433	PPAR	Metabolic Disease
GW 2433 is a dual PPARα and PPARδ agonist. GW 2433 has the potential for the study of type II diabetes and dyslipidemia .

HY-162042

AMPK activator 14	AMPK	Metabolic Disease
AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes .

HY-145985

CBR-3465	Bacterial	Infection
CBR-3465 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.16 μM against Mtb .

HY-145986

CBR-6672	Bacterial	Infection
CBR-6672 is a mycobacterium tuberculosis (Mtb) type II NADH dehydrogenase inhibitor, with the MIC of 0.14 μM against Mtb .

HY-13635A

Finasteride acetate MK-906 acetate	5 alpha Reductase	Cancer
Finasteride (MK-906) acetate is a potent and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride acetate has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride acetate can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-P3674

LH-RH (7-10)	GnRH Receptor	Endocrinology
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes .

HY-108196

PTP1B-IN-15	Phosphatase	Endocrinology
PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity .

HY-13635

Finasteride 4 Publications Verification MK-906	5 alpha Reductase	Cancer
Finasteride (MK-906) is an orally active and competitive 5α-reductase inhibitor, with an IC₅₀ of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia .

HY-112603

AP5	Free Fatty Acid Receptor	Metabolic Disease
AP5 is a potent, orlly active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 demonstrates rat and human inositol monophosphate (IP1) EC₅₀ values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 has the potential for type II diabetes research .

HY-112603A

AP5 sodium	Free Fatty Acid Receptor	Metabolic Disease
AP5 sodium is a potent, orall active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 sodium demonstrates rat and human inositol monophosphate (IP1) EC₅₀ values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 sodium has the potential for type II diabetes research .

HY-14810

Atigliflozin AVE-2268	SGLT	Metabolic Disease
Atigliflozin (AVE-2268) is an orally active and selective SGLT-2 inhibitor, with IC₅₀s of 10 nM and 8.2 μM for hSGLT-2 and hSGLT-1) respectively. Atigliflozin can lower the blood glucose and improve the impaired oral glucose tolerance. Atigliflozin can be used for research of type II diabetes mellitus .

HY-P2501

Amylin (8-37), human	Amylin Receptor	Metabolic Disease
Amylin (8-37), human is a fragment of human Amylin. Amylin (8-37), human has direct vasodilator effects in the isolated mesenteric resistance artery of the rat. Human Amylin is a small hormone secreted by pancreatic β-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus .

HY-16619

AM-5262	Free Fatty Acid Receptor	Metabolic Disease
AM-5262 is a GPR40 full agonist with an EC₅₀ value of 0.081 μM. AM-5262 can be used for the research of type II diabetes .

HY-147964

α-Glucosidase-IN-9	Glycosidase	Metabolic Disease
α-Glucosidase-IN-9 (compound 7) is a potent α-glucosidase inhibitor, with an IC₅₀ of 55.6 μM. α-Glucosidase-IN-9 can be used for type II diabetes research .

HY-147965

α-Glucosidase-IN-10	Glycosidase	Metabolic Disease
α-Glucosidase-IN-10 (compound 13) is a potent α-glucosidase inhibitor, with an IC₅₀ of 92.7 μM. α-Glucosidase-IN-10 can be used for type II diabetes research .

HY-148072

MM3122	SARS-CoV	Infection
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC₅₀ value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells .

HY-109500

Masoprocol meso-Nordihydroguaiaretic acid; meso-NDGA	Lipoxygenase	Metabolic Disease Cancer
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes .

HY-114564

Satigrel E5510	Prostaglandin Receptor	Cardiovascular Disease
Satigrel (E5510) is a potent inhibitor of platelet aggregation. Satigrel inhibits collagen- and arachidonic acid-induced platelet aggregation through preventing thromboxane A2 synthesis by selective inhibition of the target enzyme, PGHS1, which exists in platelets. Satigrel inhibits PGHS1 (IC₅₀: 0.081 μM) and PGHS2 (IC₅₀: 5.9 μM). Satigrel is against Type III PDE, Type V and Type II (IC₅₀: 15.7 μM, 39.8 μM and 62.4 μM, respectively) .

HY-N9153A

Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether	Others	Metabolic Disease
Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether is a DGAT1 inhibitor with an IC₅₀ of 92.7 μM and can be extracted from Eleutherococcus senticosus. Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether can be utilized in research related to type II diabetes and obesity .

HY-P4767

Amylin (1-13) (human)	Amylin Receptor	Metabolic Disease
Amylin (1-13) (human) is a fragment and a residues within amyloid cores of Amylin (human IAPP). Amylin is a glucose-regulating hormone, deposits as amyloid fibrils in condition of type II diabetes (T2D). Amylin (1-13) (human) has no effect on firbl formation, as it cannot form fibrils by itself .

HY-103195

NKY80 2 Publications Verification	Adenylate Cyclase	Metabolic Disease
NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC₅₀s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues .

HY-120160A

Darglitazone Sodium CP 86325 Sodium	PPAR	Neurological Disease Metabolic Disease
Darglitazone Sodium, a thiazolidinedione, is an orally active, potent, and selective PPAR-γ (peroxisome proliferator-activated receptor) agonist. Darglitazone Sodium is effective in controlling blood glucose and lipid metabolism, and can be used for type II diabetes research .

HY-128348

PK68	RIP kinase	Inflammation/Immunology Cancer
PK68 is a potent orally active and specifical type II inhibitor of receptor-interacting kinase 1 (RIPK1) with an IC₅₀ of ~90 nM, displays inhibition of RIPK1-dependent necroptosis. PK68 powerfully ameliorates TNF-induced systemic inflammatory response syndrome, and can be used for the research of inflammatory disorders and cancer metastasis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-109500

Masoprocol meso-Nordihydroguaiaretic acid; meso-NDGA	other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Lipoxygenase
Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes .

HY-W011303

Phytosphingosine 1 Publications Verification 4-Hydroxysphinganine	Infection Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-13948

Angiotensin II human Maximum Cited Publications 125 Publications Verification Angiotensin II; Ang II; DRVYIHPF	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Cancer	Angiotensin Receptor Apoptosis
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-N0891

Tubeimoside II Tubeimoside-B	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Tubeimoside II (Tubeimoside-B) is a natural analogue of oleanane type of triterpenoid saponin; show anti-inflammatory, antitumor, and antitumor-promoting effects.

HY-N2589

Isosaponarin	Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae	TGF-β Receptor
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin increases collagen synthesis, caused by up-regulated *TGF-β type* II receptor (TβR-II) and prolyl 4-hydroxylase (P4H)** proteins production .

HY-B0199A

Mycophenolate mofetil hydrochloride 5+ Cited Publications RS 61443 hydrochloride; TM-MMF hydrochloride	Structural Classification Monophenols Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Bacterial
Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-N9153A

Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether	Structural Classification Monophenols Source classification Phenols Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Others
Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether is a DGAT1 inhibitor with an IC₅₀ of 92.7 μM and can be extracted from Eleutherococcus senticosus. Guaiacylglycerol-8-O-4'-(sinapyl alcohol) ether can be utilized in research related to type II diabetes and obesity .

HY-N7542

Praeroside II	Natural Products Chrysanthemum × morifolium (Ramat.) Hemsl. Plants Umbelliferae	Others
Praeroside II is an *angular-type* pyranocoumarm glycoside*. Praeroside II can be isolated from the n-butanol-extracts of P. praeruptorum Dunn*. Praeroside II can be used for pharmacological study .

HY-113767

Momordin II	Triterpenes Structural Classification Terpenoids Source classification Cucurbitaceae Plants Momordica charantia Linn.	DNA/RNA Synthesis
Momordin II, an oleanane-type triterpene glycoside, is a ribosome inactivating protein. Momordin II inhibits cell-free protein synthesis, releases adenine from rat liver ribosomes and from DNA, and has no RNase activity .

HY-N3269

Methyl p-hydroxyphenyllactate	Monophenols Classification of Application Fields Labiatae Source classification Other Diseases Phenols Peucephyllum schottii A.Gray Plants Disease Research Fields	Others
Methyl p-hydroxyphenyllactate (MeHPLA) is an important cell growth-regulating agent which binds to nuclear type II binding sites in normal and malignant cells .

HY-N12191

Cangorinine E-1	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Celastraceae Plants Tripterygium wilfordii Hook. f.	HSV
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) .

HY-131577

Neutral protease, Paenibacillus polymyxa 1 Publications Verification Dispase II, Dispase	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Neutral protease, Paenibacillus polymyxa (Dispase II, Dispase) is a neutral protease and potent fibronectinase and type IV collagenase. Neutral protease, Paenibacillus polymyxa can be used to separate the intact epidermis from the dermis and intact epithelial sheets in culture from the substratum .

HY-42680

D-Tagatose D-(-)-Tagatose	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Sweeteners Saccharides Monosaccharides Food Research	Endogenous Metabolite
D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice, and beverages. D-Tagatose is also a potential antidiabetic agent for the research of type II diabetes and a prebiotic to help elevate beneficial bacteria in the colon, prevent colon cancer, and lower cholesterol .

HY-N6732

K-252a 15+ Cited Publications SF2370; Antibiotic K 252a; Antibiotic SF 2370	Alkaloids Structural Classification Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields Indole Alkaloids	PKC PKA CaMK Trk Receptor Autophagy Antibiotic
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

HY-W011303A

(Rac)-Phytosphingosine (Rac)-4-Hydroxysphinganine	Structural Classification Natural Products other families Source classification Plants	Apoptosis
(Rac)-Phytosphingosine ((Rac)-4-Hydroxysphinganine) is the racemate of Phytosphingosine (HY-W011303). Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-42680R

D-Tagatose (Standard)	Structural Classification Microorganisms Source classification Endogenous metabolite Saccharides Monosaccharides	Endogenous Metabolite
D-Tagatose (Standard) is the analytical standard of D-Tagatose. This product is intended for research and analytical applications. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice, and beverages. D-Tagatose is also a potential antidiabetic agent for the research of type II diabetes and a prebiotic to help elevate beneficial bacteria in the colon, prevent colon cancer, and lower cholesterol .

HY-B1234

Octinoxate Octyl methoxycinnamate	Structural Classification Natural Products other families Classification of Application Fields Source classification Other Diseases Cosmetic Research Plants Disease Research Fields	Androgen Receptor Estrogen Receptor/ERR Thyroid Hormone Receptor Cytochrome P450
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

HY-N0716

Berberine Natural Yellow 18	Structural Classification Classification of Application Fields Anti-aging Ranunculaceae Source classification Plants Endogenous metabolite Biological Pesticide Research Agricultural Research Alkaloids Coptis chinensis Franch. Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Cancer	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-N0716B

Berberine sulfate 45+ Cited Publications Natural Yellow 18 sulfate	Alkaloids Structural Classification Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine sulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine sulfate induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine sulfate has antineoplastic properties. The sulfate form improves bioavailability .

HY-N0716A

Berberine hemisulfate 45+ Cited Publications Natural Yellow 18 hemisulfate	Infection Structural Classification Alkaloids Classification of Application Fields Coptis chinensis Franch. Ranunculaceae Source classification Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields Cancer	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity .

HY-N0716AR

Berberine (hemisulfate) (Standard)	Structural Classification Alkaloids Coptis chinensis Franch. Ranunculaceae Source classification Plants Isoquinoline Alkaloids	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine (hemisulfate) (Standard) is the analytical standard of Berberine (hemisulfate). This product is intended for research and analytical applications. Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity .

HY-N0716R

Berberine (Standard)	Alkaloids Structural Classification Coptis chinensis Franch. Ranunculaceae Source classification Plants Endogenous metabolite Isoquinoline Alkaloids	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB
Berberine (Standard) is the analytical standard of Berberine. This product is intended for research and analytical applications. Berberine (Natural Yellow 18) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. Berberine (Natural Yellow 18) induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase. Berberine (Natural Yellow 18) has antineoplastic properties. The sulfate form (HY-N0716B) improves bioavailability .

HY-N0716BR

Berberine (sulfate) (Standard)	Alkaloids Structural Classification Coptis chinensis Franch. Ranunculaceae Source classification Plants Isoquinoline Alkaloids	Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species Parasite Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB

HY-W011303R

Phytosphingosine (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Source classification Endogenous metabolite	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor

Cat. No.	Product Name	Chemical Structure

HY-13948BS

Angiotensin II human-13C6,15N TFA

Angiotensin II human- ¹³C₆, ¹⁵N TFA (Ang II- ¹³C₆, ¹⁵N TFA) is ¹³C- and ¹⁵N-labeled Angiotensin II human (TFA) (HY-13948B). Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions .

HY-13635S

Finasteride-d9

Finasteride-d₉ is deuterium labeled Finasteride. Finasteride (MK-906) is a potent and competitive 5α-reductase inhibitor, with an IC50 of 4.2 nM for type II 5α-reductase. Finasteride has approximately a 100-fold greater affinity for type II 5α-reductase enzyme than for the type I enzyme. Finasteride can be used for the research of benign prostatic hyperplasia (BPH) and androgenic alopecia[1][2][3].

HY-14914S

Azilsartan-d5
Azilsartan-d₅ is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.

HY-B0202S

Irbesartan-d4
Irbesartan-d₄ is the deuterium labeled Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist.

HY-B0202S3

Irbesartan-d7
Irbesartan-d₇ is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active *Ang II type* 1 (AT1) receptor blocker (ARB)**. Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0202AS

Irbesartan-d7 hydrochloride

Irbesartan-d₇ hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-17512AS

Losartan-d6 hydrochloride
Losartan-d₆ hydrochloride is deuterated labeled Losartan potassium (HY-17512A). Losartan potassium (DuP-753 potassium) is an *angiotensin II receptor type* 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀** of 20 nM.

HY-W005288S

4-Vinylphenol-d4
4-Vinylphenol-d₄ is deuterated labeled Losartan (potassium) (HY-17512A). Losartan potassium (DuP-753 potassium) is an *angiotensin II receptor type* 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀** of 20 nM.

HY-B0202S1

Irbesartan-d6
Irbesartan-d₆ is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

HY-13955S1

Telmisartan-d4
Telmisartan-d₄ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

HY-13955S

Telmisartan-d3
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM[1][2].

HY-B0199AS

Mycophenolate Mofetil-d4 hydrochloride
Mycophenolate Mofetil-d₄ hydrochloride is deuterated labeled Mycophenolate mofetil hydrochloride (HY-B0199A). Mycophenolate mofetil (RS 61443) hydrochloride is a immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPD) type I/II with IC₅₀s of 39 nM and 27 nM, respectively.

HY-13955S2

Telmisartan-13C,d3
Telmisartan- ¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

HY-13955S3

Telmisartan-d7
Telmisartan-d₇ (BIBR 277-d₇) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of *angiotensin II type* 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀** of 9.2 nM.

HY-B1837S

Cyfluthrin-d6
Cyfluthrin-d₆ (β-Cyfluthi-d₆) is deuterium labeled Cyfluthrin. Cyfluthrin is a type II pyrethroid and has effects on various insects. Cyfluthrin is a modulator of Nav_1.8 sodium channels by repetitive stimulation. Cyfluthrin can be applied in agriculture,veterinary, insecticide,pyrethroid and stored product .

HY-12765S1

Losartan carboxylic acid-d4 hydrochloride

Losartan carboxylic acid-d₄ (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].

HY-14914S1

Azilsartan-d4
Azilsartan-d₄ is the deuterium labeled Azilsartan[1]. Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research[2][3][4][5][6].

HY-B0202S2

Irbesartan-d6-1
Irbesartan-d₆-1 is the deuterium labeled Irbesartan[1]. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[2].

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-W011303S

Phytosphingosine-d7

Phytosphingosine-d₇ (4-Hydroxysphinganine-d₇) is deuterium labeled Phytosphingosine. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-B1234S

Octinoxate-13C,d3

Octinoxate-13C,d3 is the deuterium labeled Octinoxate (HY-W245806). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo .

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