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Cleavage

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) AIM2 (1) Akt (2) AMPK (1) Amyloid-β (6) Anaplastic lymphoma kinase (ALK) (1) Antibiotic (9) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (41) ATP Citrate Lyase (5) Bacterial (13) Bcl-2 Family (1) Beta-secretase (3) Biochemical Assay Reagents (7) Bradykinin Receptor (3) c-Myc (1) Calcium Channel (2) Casein Kinase (1) Caspase (13) Cathepsin (7) CDK (2) Ceramidase (1) Cholinesterase (ChE) (2) Complement System (7) CRISPR/Cas9 (2) Cytochrome P450 (5) Dengue virus (2) Deubiquitinase (1) Dihydrofolate reductase (DHFR) (1) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (8) Drug Metabolite (2) Drug-Linker Conjugates for ADC (1) Dynamin (1) Elastase (2) Endogenous Metabolite (17) Enterovirus (1) Epigenetic Reader Domain (1) ERK (1) Factor Xa (3) Fatty Acid Synthase (FASN) (2) Flavivirus (2) Fluorescent Dye (12) Fungal (4) Furin (1) GCGR (3) GLP Receptor (1) Glucosidase (1) GnRH Receptor (1) HCV Protease (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (3) HIV (1) HIV Protease (4) HSV (1) IAP (1) IGF-1R (1) IKK (1) Influenza Virus (3) Integrin (1) Interleukin Related (4) IRAK (1) IRE1 (2) Isotope-Labeled Compounds (1) JNK (2) MALT1 (1) MDM-2/p53 (1) Microtubule/Tubulin (1) MMP (4) nAChR (2) NF-κB (5) NOD-like Receptor (NLR) (3) Notch (3) Nucleoside Antimetabolite/Analog (1) Opioid Receptor (2) Organoid (2) P-glycoprotein (2) Parasite (2) PARP (8) PCSK9 (1) PD-1/PD-L1 (3) Phosphatase (2) Phosphodiesterase (PDE) (1) Phospholipase (1) PKC (3) Polo-like Kinase (PLK) (1) PPAR (2) PROTACs (2) Protease Activated Receptor (PAR) (1) Proteasome (2) Pyroptosis (1) Raf (1) Ras (2) Reactive Oxygen Species (1) Reverse Transcriptase (1) Ribosomal S6 Kinase (RSK) (1) ROS Kinase (1) SARS-CoV (3) Ser/Thr Protease (1) Sirtuin (1) STAT (1) Thrombin (2) TNF Receptor (1) Topoisomerase (15) Virus Protease (1) Wnt (1) γ-secretase (5)
By Research Areas:	Cancer (89) Cardiovascular Disease (15) Infection (40) Inflammation/Immunology (35) Metabolic Disease (27) Neurological Disease (22)
Click Chemistry:	Azide (1)
Oligonucleotides:	Nucleoside Phosphoramidites (1) Aptamers (1) mRNA (1)

232

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

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Inhibitory Antibodies

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Isotope-Labeled Compounds

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N8245

2',3'-cGMP sodium Guanosine 2',3'-cyclic monophosphate sodium salt	Others	Others
2',3'-cGMP sodium, a cGMP analogue, is an intermediate of RNA catalytic cleavage by binase .

HY-125598

Secologanin	Others	Others
Secologanin, a secoiridoid glucoside, is a pivotal terpenoid intermediate in the biosynthesis of biologically active monoterpenoid indole alkaloids such as reserpine, ajmaline, and vinblastine. Secologanin synthase (cytochrome P450 isoform CYP72A1) catalyzes the oxidative cleavage of loganin into Secologanin .

HY-19024

Merbarone NSC 336628	Topoisomerase	Cancer
Merbarone (NSC 336628) is an orally active inhibitor of topoisomerase II. Merbarone acts primarily by blocking topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. Merbarone is an anticancer agent .

HY-19296

BDCRB 2-Bromo-5,6-dichloro-1-β-D-ribofuranosyl benzimidazole	Others	Infection
BDCRB is a selective Human cytomegalovirus (HCMV) inhibitor through blocking the maturational cleavage of high-molecular-weight DNA. BDCRB shows a mean IC₅₀ of 0.03 μM for viral yield at 72 h postinfection .

HY-148649

Demethyl bleomycin A2	Antibiotic	Others
Demethyl bleomycin A2 is a Bleomycin (HY-108345) congener. The DNA cleavage of demethyl bleomycin A2 is insensitive to the presence of 5-Methylcytidine (HY-113135) .

HY-P3934

HIV Protease Substrate I	HIV Protease	Infection
HIV Protease Substrate I is a chromogenic substrate of HIV-1 protease. HIV Protease Substrate I has the cleavage site of HIV protease .

HY-P2842

Aminopeptidase	Others	Others Cancer
Aminopeptidase catalyzes the cleavage of amino acids from the amino terminus of protein or peptide substrates .

HY-113630A

20β-22-Azacholesterol	Others	Others
20β-22-Azacholesterol is the β-configuration of 22-Azacholesterol (HY-113630). 20β-22-Azacholesterol is an inhibitor for cholesterol side chain cleavage reactions .

HY-P3234

Ac-ESMD-CHO	Casein Kinase	Others
Ac-ESMD-CHO is an inhibitor of caspase-3 and caspase-7. Ac-ESMD-CHO inhibits proteolytic cleavage of the caspase-3 precursor peptide (CPP32) at the Glu-Ser-Met-Asp (ESMD) site .

HY-N7569

Demethoxyfumitremorgin C	Apoptosis Caspase PPAR	Cancer
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to *PARP/ cleavage* .**

HY-108882

DNase I, Bovine pancreas 5 Publications Verification DNase	Others	Inflammation/Immunology Cancer
DNase I (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer .

HY-148994

Methotrexate-γ-aspartate	Dihydrofolate reductase (DHFR)	Cardiovascular Disease
Methotrexate-γ-aspartate is a Ll210 cell dihydrofolate reductase inhibitor. Methotrexate-γ-aspartate is apparently more resistant to enzymic cleavage than is methotrexate-y-glutamate. Methotrexate-γ-aspartate is promising for research of leukemic .

HY-125598R

Secologanin (Standard)	Others	Others
Secologanin (Standard) is the analytical standard of Secologanin. This product is intended for research and analytical applications. Secologanin, a secoiridoid glucoside, is a pivotal terpenoid intermediate in the biosynthesis of biologically active monoterpenoid indole alkaloids such as reserpine, ajmaline, and vinblastine. Secologanin synthase (cytochrome P450 isoform CYP72A1) catalyzes the oxidative cleavage of loganin into Secologanin .

HY-113642

CP-67804	Topoisomerase	Cancer
CP-67804 is a quinolone derivative, is a topoisomerase II-targeted agent. CP-67804 effectively enhances DNA cleavage mediated by eukaryotic topoisomerase II. CP-67804 has potential as an antineoplastic agent .

HY-105025B

Thymocartin acetate Thymopoietin II (32-35) (acetate); TP 4 acetate	Others	Inflammation/Immunology
Thymocartin (TP 4) (acetate) is the 32-35 fragment of thymic factor (thymopoietin). The metabolic pathway of Thymocartin (acetate) in nasal mucosa occurs according to a typical amino peptidase cleavage pattern, stepwise forming Lys-Asp-Val and Asp-Val .

HY-138188

KRA-533	Ras	Cancer
KRA-533 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.

HY-161401

PAR4 antagonist 2	Protease Activated Receptor (PAR)	Cardiovascular Disease
PAR4 antagonist 2 (Compound 31) is a protease activated receptor 4 (PAR4) antagonist, with IC₅₀ values of 95 nM and 367 nM for human PAR4 and mouse PAR4. PAR4 antagonist 2 is active against PAR4 activation by the native protease thrombin cleavage but not the synthetic PAR4 agonist peptide AYPGKF .

HY-N12129

6,6′-Dihydroxythiobinupharidine	Cathepsin	Others
6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively .

HY-101597

NVX-207	Apoptosis	Cancer
NVX-207, a Betulinic acid-derived anti-cancer compound, shows anti-tumor activity (mean IC₅₀=3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of PARP .

HY-128153

Thienopyridone	Phosphatase Apoptosis	Cancer
Thienopyridone is a potent and selective phosphatase of regenerating liver (PRL) phosphatase inhibitor with IC₅₀s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively. Thienopyridone shows minimal effects on other phosphatases. Thienopyridone induces p130Cas cleavage and apoptosis and has anticancer effects .

HY-107639

UK-370106	MMP	Inflammation/Immunology
UK-370106 is a potent and highly selective MMP-3 (IC₅₀ of 23 nM) and MMP-12 (IC₅₀ of 42 nM) inhibitor with >1200-fold higher potency than MMP-1, MMP-2, MMP-9, and MMP-14, and about 100-fold than MMP-13 and MMP-8. UK-370106 potently inhibits cleavage of [ ³H]-fibronectin by MMP-3 (IC₅₀ of 320 nM) and has little effect on keratinocyte migration in vitro .

HY-17624

Framycetin Neomycin B; Fradiomycin B	Bacterial Antibiotic	Infection
Framycetin (Neomycin B), an aminoglycoside antibiotic, is a potent *RNase P cleavage* activity inhibitor with a K_i of 35 μM. Framycetin competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin inhibits hammerhead ribozyme with a K_i** of 13.5 μM. Framycetin, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections .

HY-W007926

2-Oxobutanoic acid 1 Publications Verification 2-Ketobutyrate	Endogenous Metabolite	Others
2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.

HY-17624A

Framycetin sulfate Neomycin B sulfate; Fradiomycin B sulfate	Antibiotic Bacterial	Infection
Framycetin sulfate (Neomycin B sulfate), an aminoglycoside antibiotic, is a potent *RNase P cleavage* activity inhibitor with a K_i of 35 μM. Framycetin sulfate competes for specific divalent metal ion binding sites in RNase P RNA. Framycetin sulfate inhibits hammerhead ribozyme with a K_i** of 13.5 μM. Framycetin sulfate, a 5″-azido neomycin B precursor, binds the Drosha site in miR-525 and is used for hepatic encephalopathy and enteropathogenic E. coli infections .

HY-111329

JGB1741 ILS-JGB-1741	Sirtuin Apoptosis	Cancer
JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC₅₀ of ∼15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC₅₀>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research .

HY-103538

JLK-6	Amyloid-β	Neurological Disease
JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor .

HY-113915

Kuguaglycoside C	Apoptosis	Neurological Disease Cancer
Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C induces caspase‐independent DNA cleavage and cell death of neuroblastoma cells. Kuguaglycoside C also significantly increases the expression and cleavage of apoptosis-inducing factor (AIF) .

HY-100951

Beaucage reagent 1 Publications Verification	DNA/RNA Synthesis	Cancer
Beaucage reagent is found to be potent in causing DNA cleavage .

HY-N5048

Galloylpaeoniflorin 6'-O-Galloyl paeoniflorin	NF-κB	Others
Galloylpaeoniflorin is a NF-κB inhibitor . And Galloylpaeoniflorin is a inhibitor of DNA cleavage .

HY-156628

Opevesostat	Cytochrome P450	Others
Opevesostat is a cholesterol side-chain cleavage enzyme (CYP11A1) inhibitor .

HY-126488

H-Ser-His-OH	Endogenous Metabolite	Metabolic Disease
H-Ser-His-OH is a short peptide with hydrolysis cleavage activity, an endogenous metabolite .

HY-W341421

3-Indoxyl butyrate	Biochemical Assay Reagents	Others
3-Indoxyl butyrate is a chromogenic substrate for CES (carboxylesterase), producing a blue precipitate upon cleavage.

HY-13618

Edotecarin J 107088; PF 804950	Topoisomerase	Cancer
Edotecarin is a potent inhibitor of topoisomerase I that can induces single-strand DNA cleavage, with IC₅₀ of 50 nM.

HY-D1685

BZiPAR	Fluorescent Dye	Others
BZiPAR is a fluorescent probe. BZiPAR also is a substrate of trypsin that becomes fluorescent after cleavage by the protease .

HY-18350

Indimitecan LMP776	Topoisomerase	Cancer
Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities .

HY-137802

SAHO2 S-Adenosyl-L-homocysteine sulfone	Others	Others
SAHO2 is the sulfone form of the methyl donor S-(5'-adenosyl)-L-methionine chloride (SAM) and serves as a substrate for radical SAM enzymes .

HY-163738

Furin-IN-2	Furin SARS-CoV	Infection
Furin-IN-2 (compound P3) is a potent inhibitor of furin, with the IC₅₀ of 35 μM. Furin-IN-2 shows antiviral activity .

HY-18350A

Indimitecan hydrochloride LMP776 hydrochloride	Topoisomerase	Cancer
Indimitecan hydrochloride is a topoisomerase I (Top1) inhibitor with anticancer activities .

HY-P5830

Biotin-DEVD-CHO	Caspase	Others
Biotin-DEVD-CHO can be used for affinity labeling of Caspase-8 following in vitro caspase cleavage .

HY-N0499A

Cyanidin	Others	Inflammation/Immunology
Cyanidin, an antioxidant, has protective effect on DNA cleavage, free radical scavenging activity and significant inhibition of XO activity .

HY-120185

Saintopin UCT-1003	Topoisomerase	Infection Cancer
Saintopin is an antitumor antibiotic. Saintopin is also an inhibitor of DNA topoisomerases I and II. Saintopin induces DNA cleavage .

HY-103248

Toyocamycin 5 Publications Verification Vengicide	IRE1 Fungal Antibiotic Apoptosis CDK	Infection Cancer
Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC₅₀ value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC₅₀ value of 79 nM .

HY-148614

Isocaproaldehyde 4-Methylpentanal; 4-Methylvaleraldehyde	Others	Metabolic Disease
Isocaproaldehyde is a product of side-chain cleavage of cholesterol. Isocaproaldehyde is an endogenous specific substrate of mouse vas deferens protein (MVDP) .

HY-E70042

Nucleoside hydrolase (IAGNH)	Endogenous Metabolite	Metabolic Disease
Nucleoside hydrolase (IAGNH) is a glycosidase. Nucleoside hydrolase (IAGNH) catalyzes the cleavage of the N-glycosidic bond in nucleosides to enable the recycling of the nucleobases and Rib .

HY-P3632

[DAla2, DArg6] Dynorphin A, (1-13) (porcine) DADAD	Opioid Receptor	Neurological Disease Metabolic Disease
[DAla2, DArg6] Dynorphin A, (1-13) (porcine) (DADAD) is an opioid peptide (dynorphinl-13, DYN) derivative found in porcine pituitary extracts. DYN is highly potent at the peripheral opioid receptors GPI and MVD, but is readily and rapidly degraded in vivo. [DAla2, DArg6] Dynorphin A, (1-13) (porcine) has some resistance to enzymatic cleavage and prevents peptide cleavage by enzymes .

HY-P2610

Ac-VEID-pNA	Caspase	Others
Ac-VEID-pNA is an artificially synthesized peptide. Ac-VEID-pNA is utilized as substrate for caspase 6, that cleaves the lamin A at the cleavage site of VEID .

HY-13526

YO-01027 4 Publications Verification Dibenzazepine; DBZ	Notch γ-secretase	Cancer
YO-01027 (Dibenzazepine;DBZ) is a potent γ-secretase inhibitor with IC₅₀ values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively.

HY-147509

SBP-3	Fluorescent Dye	Others
SBP-3 is a sulfite bioluminescent probe (SBP). The recognition of SBP-3 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction .

HY-147508

SBP-2	Fluorescent Dye	Others
SBP-2 is a sulfite bioluminescent probe (SBP). The recognition of SBP-2 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction .

HY-W357151

6-Chloro-3-indoxyl-α-D-mannopyranoside	Fluorescent Dye	Others
6-Chloro-3-indoxyl-α-D-mannopyranoside is a chromogenic substrate for α-mannosidase resulting in a salmon colored precipitate upon cleavage.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125598

Secologanin	Structural Classification Caprifoliaceae Iridoids Classification of Application Fields Lonicera japonica Thunb. Terpenoids Source classification Other Diseases Plants Disease Research Fields	Others
Secologanin, a secoiridoid glucoside, is a pivotal terpenoid intermediate in the biosynthesis of biologically active monoterpenoid indole alkaloids such as reserpine, ajmaline, and vinblastine. Secologanin synthase (cytochrome P450 isoform CYP72A1) catalyzes the oxidative cleavage of loganin into Secologanin .

HY-W007926

2-Oxobutanoic acid 1 Publications Verification 2-Ketobutyrate	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.

HY-N5048

Galloylpaeoniflorin 6'-O-Galloyl paeoniflorin	Classification of Application Fields Paeonia lactiflora Pall. Source classification Other Diseases Phenols Polyphenols Plants Paeoniaceae Disease Research Fields	NF-κB
Galloylpaeoniflorin is a NF-κB inhibitor . And Galloylpaeoniflorin is a inhibitor of DNA cleavage .

HY-126488

H-Ser-His-OH	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
H-Ser-His-OH is a short peptide with hydrolysis cleavage activity, an endogenous metabolite .

HY-P2842

Aminopeptidase	Classification of Application Fields Disease Research Fields Cancer	Others
Aminopeptidase catalyzes the cleavage of amino acids from the amino terminus of protein or peptide substrates .

HY-113630A

20β-22-Azacholesterol	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Others
20β-22-Azacholesterol is the β-configuration of 22-Azacholesterol (HY-113630). 20β-22-Azacholesterol is an inhibitor for cholesterol side chain cleavage reactions .

HY-N7569

Demethoxyfumitremorgin C	Structural Classification Alkaloids Microorganisms Source classification Marine natural products Other marine organisms Indole Alkaloids	Apoptosis Caspase PPAR
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to *PARP/ cleavage* .**

HY-125598R

Secologanin (Standard)	Structural Classification Caprifoliaceae Iridoids Lonicera japonica Thunb. Terpenoids Source classification Plants	Others
Secologanin (Standard) is the analytical standard of Secologanin. This product is intended for research and analytical applications. Secologanin, a secoiridoid glucoside, is a pivotal terpenoid intermediate in the biosynthesis of biologically active monoterpenoid indole alkaloids such as reserpine, ajmaline, and vinblastine. Secologanin synthase (cytochrome P450 isoform CYP72A1) catalyzes the oxidative cleavage of loganin into Secologanin .

HY-N12129

6,6′-Dihydroxythiobinupharidine	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Plants Nuphar pumila (Timm) de Candolle Nymphaeaceae	Cathepsin
6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively .

HY-113915

Kuguaglycoside C	Structural Classification Natural Products Source classification Cucurbitaceae Plants Momordica charantia Linn.	Apoptosis
Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C induces caspase‐independent DNA cleavage and cell death of neuroblastoma cells. Kuguaglycoside C also significantly increases the expression and cleavage of apoptosis-inducing factor (AIF) .

HY-N0499A

Cyanidin	Structural Classification Caprifoliaceae Source classification Phenols Polyphenols Sambucus williamsii Hance Plants	Others
Cyanidin, an antioxidant, has protective effect on DNA cleavage, free radical scavenging activity and significant inhibition of XO activity .

HY-103248

Toyocamycin 5 Publications Verification Vengicide	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Disease Research Fields Other Antibiotics	IRE1 Fungal Antibiotic Apoptosis CDK
Toyocamycin (Vengicide) is an adenosine analog produced by Streptomyces diastatochromogenes, acts as an XBP1 inhibitor. Toyocamycin blocks RNA synthesis and ribosome function, and induces apoptosis. Toyocamycin affects IRE1α-XBP1 pathway, and inhibits XBP1 mRNA cleavage with an IC₅₀ value of 80 nM with affecting IRE1α auto-phosphorylation. Toyocamycin specifically inhibits CDK9 with an IC₅₀ value of 79 nM .

HY-148614

Isocaproaldehyde 4-Methylpentanal; 4-Methylvaleraldehyde	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
Isocaproaldehyde is a product of side-chain cleavage of cholesterol. Isocaproaldehyde is an endogenous specific substrate of mouse vas deferens protein (MVDP) .

HY-W007926R

2-Oxobutanoic acid (Standard) 2-Ketobutyrate (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite	Endogenous Metabolite
2-Oxobutanoic acid (Standard) is the analytical standard of 2-Oxobutanoic acid. This product is intended for research and analytical applications. 2-Oxobutanoic acid is a product in the enzymatic cleavage of cystathionine.

HY-13434

Ionomycin Maximum Cited Publications 61 Publications Verification SQ23377	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC) .

HY-13434A

Ionomycin calcium Maximum Cited Publications 61 Publications Verification SQ23377 calcium	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Disease Research Anticancer Disease Research Fields Other Antibiotics	Calcium Channel PKC Bacterial Apoptosis Antibiotic
Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC) .

HY-126490

Phleomycin	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Disease Research Fields Other Antibiotics	Bacterial Antibiotic DNA/RNA Synthesis
Phleomycin is an anticancer glycopeptide antibiotic found in Streptomyces verticillus, which cause DNA cleavage. Phleomycin binds and intercalates DNA to damage the integrity of the double helix, which is similar to Bleomycin (HY-17565A) .

HY-113091

Alpha-Tocotrienol	Structural Classification Monophenols Animals Source classification Phenols Endogenous metabolite	Apoptosis
Alpha-Tocotrienol is a vitamin E analog with anti-apoptotic neuroprotective action and antioxidant properties. Alpha-Tocotrienol prevents oxidative stress-independent apoptotic cell death, DNA cleavage, and nuclear morphological changes .

HY-N6865

Groenlandicine 2 Publications Verification	Alkaloids Piperidine Alkaloids Monophenols Classification of Application Fields Source classification Ranunculaceae Coptis chinensis Franch. Phenols Metabolic Disease Plants Isoquinoline Alkaloids Disease Research Fields	Topoisomerase
Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC₅₀ value of 154.2 μM for human recombinant aldose reductase (HRAR) . Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage .

HY-112058

Distamycin A NSC-82150	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Apoptosis
Distamycin A (NSC-82150), an oligopeptide antibiotic, is a minor groove binder which binds to B-form DNA, preferentially at A/T rich sites.Distamycin A can change Enediyne-induced DNA cleavage sites and enhances apoptosis .

HY-N2374

Eupatorin	Structural Classification Flavonoids Classification of Application Fields Flavones Cruciferae Source classification Phenols Polyphenols Isatis tinctoria L. Plants Disease Research Fields Cancer	Apoptosis
Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-N6861

Lucidenic acid B	Triterpenes Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Endogenous metabolite Disease Research Fields Cancer	Apoptosis
Lucidenic acid B is a natural compound isolated from Ganoderma lucidum, induces apoptosis of cancer cells, and causes the activation of caspase-9 and caspase-3, and cleavage of PARP. Lucidenic acid B does not affect the cell cycle profile, or the number of necrotic cells .

HY-134313A

8-NH2-ATP tetrasodium 8-Aminoadenosine-5'-O-triphosphate tetrasodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Endogenous Metabolite
8-NH2-ATP tetrasodium, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado tetrasodium induces apoptosis-related cleavage of poly (ADP-ribose) polymerase .

HY-113245

3-Indolyl-β-D-glucuronide	Structural Classification Alkaloids Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields Indole Alkaloids	Endogenous Metabolite
3-Indolyl-β-D-glucuronide, a chromogenic substrate for β-D-glucuronidase, employs in the detection and enumeration of E. coli, yielding a blue precipitate upon cleavage. 3-Indolyl-β-D-glucuronide in? patients' plasma act as a new indicator of renal failure .

HY-N7347

(-)-Hydroxycitric acid lactone Garcinia lactone	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Plants Disease Research Fields	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-134313

8-NH2-ATP 8-Aminoadenosine-5'-O-triphosphate	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Endogenous Metabolite
8-NH2-ATP, an inactive form of ATP, is produced by 8-NH2-Ado. 8-NH2-Ado is reported to be potent as shown by induction of apoptosis-related cleavage of poly (ADP-ribose) polymerase .

HY-113056A

N1-Acetylspermidine hydrochloride	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA .

HY-N2374R

Eupatorin (Standard)	Structural Classification Flavonoids Classification of Application Fields Cruciferae Source classification Phenols Isatis tinctoria L. Plants Disease Research Fields Cancer	Apoptosis
Eupatorin (Standard) is the analytical standard of Eupatorin. This product is intended for research and analytical applications. Eupatorin, a naturally occurring flavone, arrests cells at the G2-M phase of the cell cycle and induces apoptotic cell death involving activation of multiple caspases, mitochondrial release of cytochrome c and poly(ADP-ribose) polymerase cleavage .

HY-W748591

Cannflavin A	Structural Classification Flavonoids Cannabis sativa L Flavones Source classification Plants Moraceae	Apoptosis Amyloid-β
Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO). Cannflavin A activates apoptosis via caspase-3 cleavage .

HY-P9914

Eculizumab Anti-Human C5, Humanized Antibody	Classification of Application Fields Disease Research Fields Cancer	Complement System
Eculizumab (Anti-Human C5, Humanized Antibody) is a long-acting humanized monoclonal antibody targeted against complement C5. Eculizumab inhibits the cleavage of C5 into C5a and C5b and hence inhibits deployment of the terminal complement system including the formation of membrane attack complex (MAC). Eculizumab has the potential for haemolysis research .

HY-W748509

Pipernonaline	Piper longum Linn. Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants	Caspase Apoptosis
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca(2+), and mitochondrial membrane depolarization .

HY-N7168A

3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol	Structural Classification Terpenoids Source classification Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants	Others
3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol (compound 6) is a diterpene that can be isolated from Euphorbia kansui. 3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol shows cleavage inhibition activity of individual Xenopus cells at the blastular stage .

HY-N7347R

(-)-Hydroxycitric acid lactone (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	ATP Citrate Lyase
(-)-Hydroxycitric acid lactone (Standard) is the analytical standard of (-)-Hydroxycitric acid lactone. This product is intended for research and analytical applications. (-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent and a popular weight loss food supplement. (-)-Hydroxycitric acid lactone is a potent inhibitor of ATP-citrate lyase. (-)-Hydroxycitric acid lactone catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA, limits the availability of acetyl-CoA units required for fatty acid synthesis .

HY-W009310

9-cis-Retinal	Structural Classification Classification of Application Fields Terpenoids Source classification Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields	Endogenous Metabolite Organoid
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to cellular retinol-binding protein-I (CRBP-I) and CRBP-II with K_ds of 8 nM and 5 nM, respectively. 9-cis-Retinal expedites differentiation and maturation of rod photoreceptors in retinal organoids .

HY-B1295

Lithium citrate tetrahydrate 20+ Cited Publications Litarex tetrahydrate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	ATP Citrate Lyase Bacterial HIF/HIF Prolyl-Hydroxylase Endogenous Metabolite
Lithium citrate (Litarex) tetrahydrate is the major active ingredient of Garcinia cambogia. Lithium citrate tetrahydrate competitively inhibits ATP citrate lyase with weight loss benefits. Lithium citrate tetrahydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-W009156

Citric acid tripotassium hydrate 20+ Cited Publications Potassium citrate monohydrate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Guttiferae Metabolic Disease Plants Garcinia cambogia Inflammation/Immunology Disease Research Fields	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase Bacterial Endogenous Metabolite
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-W009156R

Citric acid tripotassium hydrate (Standard)	Structural Classification Ketones, Aldehydes, Acids Guttiferae Plants Garcinia cambogia	ATP Citrate Lyase HIF/HIF Prolyl-Hydroxylase Bacterial Endogenous Metabolite
Citric acid (tripotassium hydrate) (Standard) is the analytical standard of Citric acid (tripotassium hydrate). This product is intended for research and analytical applications. Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) is the major active ingredient of Garcinia cambogia. Hydroxycitric acid tripotassium hydrate competitively inhibits ATP citrate lyase with weight loss benefits. Hydroxycitric acid tripotassium hydrate effective inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation and anti-tumor effects .

HY-107910

Hyaluronidase 5 Publications Verification Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase	Classification of Application Fields Disease Research Fields Cancer	NF-κB
Hyaluronidase (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection .

HY-N7545

Protorubradirin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Reverse Transcriptase
Protorubradirin is an antibiotic that can be isolated from Streptomyces achromogenes var. rubradirin together with Rubradirin. Protorubradirin has inhibitory activity against HIV reverse transcriptase. In vitro studies have shown that Protorubradirin also inhibits Staphylococcus aureus strains and Streptococci. In infected mice, subcutaneous injection of Protorubradirin showed in vivo inhibitory efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may result in a significant reduction in the activity of Protorubradirin, possibly due to faster cleavage of its C-nitroso sugar in the acidic gastric environment compared to Rubradirin .

Cat. No.	Product Name	Chemical Structure

HY-113056AS

N1-Acetylspermidine-d6 hydrochloride

N1-Acetylspermidine-d₆ (hydrochloride) is the deuterium labeled N1-Acetylspermidine hydrochloride. N1-Acetylspermidine hydrochloride is an acetyl derivative of polyamine. N1-acetylspermine is the substrate for the polyamine oxidase (PAO). N1-Acetylspermidine hydrochloride selectively elevates its level in human colorectal adenocarcinomas. N1-acetylspermidine shows cleavage efficiency at apurinic sites in DNA[1][2][3].

HY-50936S

Trabectedin-d3

Trabectedin D3 (Ecteinascidin 743 D3) is deuterium labeled Trabectedin. Trabectedin is a tetrahydroisoquinoline alkaloid with potent antitumor activity. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB-453 cells. Trabectedin has tje potential for soft tissue sarcoma and ovarian cancer treatment .

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