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Results for "

NK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Neurokinin Receptor (149) ADC Antibody (1) ADC Cytotoxin (1) Amino Acid Derivatives (1) Apoptosis (11) Autophagy (8) Bacterial (1) Biochemical Assay Reagents (2) Caspase (1) CD19 (1) CD38 (2) CDK (1) Checkpoint Kinase (Chk) (1) Complement System (2) Cytochrome P450 (2) Drug Metabolite (2) E1/E2/E3 Enzyme (3) Endogenous Metabolite (11) Estrogen Receptor/ERR (4) Fluorescent Dye (2) Fungal (2) Glycoprotein VI (1) HCV (1) HDAC (1) HIV (3) HMG-CoA Reductase (HMGCR) (7) IFNAR (6) Influenza Virus (1) Interleukin Related (10) Isotope-Labeled Compounds (7) JAK (1) JNK (1) Keap1-Nrf2 (1) LAG-3 (1) Liposome (1) LPL Receptor (5) mAChR (1) MAP4K (1) Mitochondrial Metabolism (1) Mitophagy (7) MMP (1) Natriuretic Peptide Receptor (NPR) (1) Neurotensin Receptor (1) NOD-like Receptor (NLR) (1) PAK (5) Parasite (1) PD-1/PD-L1 (1) PKC (1) Reactive Oxygen Species (2) SARS-CoV (2) Ser/Thr Protease (1) STAT (2) Tim3 (1) TNF Receptor (6) Toll-like Receptor (TLR) (4) Topoisomerase (2) Transmembrane Glycoprotein (2)
By Research Areas:	Cancer (83) Cardiovascular Disease (8) Endocrinology (48) Infection (17) Inflammation/Immunology (49) Metabolic Disease (13) Neurological Disease (127)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	CpG ODNs (7)

238

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Neurokinin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19734

NK-252 15+ Cited Publications	Keap1-Nrf2	Cancer
NK-252 is a potential Nrf2 activator, which exhibits a great Nrf2-activating potential.

HY-145250

NK1 receptor antagonist 2	Neurokinin Receptor	Neurological Disease
NK1 receptor antagonist 2 is a NK1 receptor antagonist. NK1 receptor antagonist 2 can be used for the research of tinnitus and hearing loss .

HY-136961

NK 1971 NK266 orotate	Fungal	Infection
NK 1971 (NK266 orotate) is a derivative of NK266 and shows potential antifungal activity. NK 1971 may result in decreased motor skills and seizures in animals .

HY-P10795

NK-2 Antibiotic NK 2	Parasite Bacterial Fungal	Infection
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed .

HY-W748297

NK 19 diiodide	Fluorescent Dye	Others
NK 19 diiodide is a photosensitive cyanin dye. NK 19 diiodide is an immunomodulator capable of modifying immunological function of the impaired lymphocytes. NK 19 diiodide can be used for research of wounds and burns .

HY-18626

NK 314	Topoisomerase	Cancer
NK 314 is an inhibitor for topoisomerase IIα, which generates the break of DNA double-strand. NK 314 arrests the cell cycle at G2 phase in human acute myeloid leukemia cells, inhibits the proliferation of CEM with IC₉₀ of 55 nM .

HY-12514

NK3201	Ser/Thr Protease
NK3201 is an orally active chymase inhibitor (IC₅₀: 2.5, 1.2, and 28 nM for human, dog and hamster chymase). NK3201 inhibits Bleomycin (HY-17565)-induced pulmonary fibrosis. NK3201 inhibits vascular proliferation in grafted vein .

HY-149358

NK3R-IN-1	Neurokinin Receptor	Endocrinology
NK3R-IN-1 (compound 16x), a imidazolepiperazine derivative, is an orally active Neurokinin Receptor *NK3R* inhibitor. NK3R-IN-1 decreases blood luteinizing hormone levels in ovariectomy (OVX) model .

HY-N10118

NK007	SARS-CoV	Infection
NK007 is a novel anti-SARS-CoV-2 agent with an EC₅₀ value of 30 nM.

HY-106659

SCH 900978 NK-1 Antagonist 1	Neurokinin Receptor	Neurological Disease Endocrinology
SCH 900978 (NK-1 Antagonist 1) is an antagonist of NK-1 receptor, used in the research of NK-1 related diseases and conditions such as cough, overactive bladder, alcohol dependency and depression .

HY-B0144

Pitavastatin Calcium 5+ Cited Publications NK-104 hemicalcium; Pitavastatin hemicalcium	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-B0144A

Pitavastatin NK-104	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-B0144B

Pitavastatin sodium NK-104 sodium	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Pitavastatin (NK-104) sodium is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin sodium inhibits cholesterol synthesis from acetic acid with an IC₅₀ of 5.8 nM in HepG2 cells. Pitavastatin sodium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin sodium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects .

HY-B0144AS1

Pitavastatin-d5 sodium NK-104-d₅ sodium	Apoptosis HMG-CoA Reductase (HMGCR) Mitophagy Autophagy	Metabolic Disease Cancer
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-B0144S

Pitavastatin-d4 hemicalcium NK-104-d₄ hemicalcium; Pitavastatin-d₄ hemicalcium	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Metabolic Disease Cancer
Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

HY-13704S

SN-38-d3 NK012-d₃	Topoisomerase ADC Cytotoxin Autophagy	Cancer
SN-38-d₃ is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].

HY-147020

Coronastat NK01-63	SARS-CoV	Infection
Coronastat is a potent inhibitor of the SARS-CoV-2 3CL protease. The SARS-CoV-2 3CL protease is a critical agent target for small molecule COVID-19, given its likely agentgability and essentiality in the viral maturation and replication cycle .

HY-B0005

Toremifene citrate 5+ Cited Publications Z-Toremifene citrate; NK 622; FC-1157a	Estrogen Receptor/ERR Apoptosis	Infection Cancer
Toremifene citrate (Z-Toremifene citrate) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 μM and 2.6 μM, respectively .

HY-P0197A

Neurokinin A TFA 3 Publications Verification Substance K TFA; Neurokinin α TFA; Neuromedin L TFA; NKA TFA	Neurokinin Receptor	Neurological Disease Endocrinology
Neurokinin A TFA (Substance K TFA), a peptide neurotransmitter of the tachykinin family, acts via the *NK-2* receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues .

HY-18006

NKP608 1 Publications Verification	Neurokinin Receptor	Neurological Disease Endocrinology
NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro(IC50=2.6 nM) and in vivo.

HY-B0005A

Toremifene 5+ Cited Publications Z-Toremifene; NK 622 free base; FC-1157a free base	Estrogen Receptor/ERR	Infection Cancer
Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 µM and 2.6 µM, respectively .

HY-B0144AS

Pitavastatin D4 NK-104 d₄	HMG-CoA Reductase (HMGCR) Autophagy Mitophagy Apoptosis	Metabolic Disease Cancer
Pitavastatin-d₄ is deuterium labeled Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.

HY-B0005S1

Toremifene-d6 hydrochloride Z-Toremifene-d₆ hydrochloride; NK 622-d₆ hydrochloride; FC-1157a-d₆ hydrochloride	Isotope-Labeled Compounds Estrogen Receptor/ERR	Infection
Toremifene-d6 (Z-Toremifene-d6) hydrochloride is deuterium labeled Toremifene. Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 µM and 2.6 µM, respectively .

HY-B0005AS

Toremifene-d6 Z-Toremifene-d₆; NK 622-d₆ free base; FC-1157a-d₆ free base	Isotope-Labeled Compounds Estrogen Receptor/ERR	Infection Cancer
Toremifene-d₆ is deuterium labeled Toremifene. Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

HY-P99143

Anti-Mouse NK1.1 Antibody (PK136)	Neurokinin Receptor	Inflammation/Immunology
Anti-Mouse NK1.1 Antibody is an anti-mouse NK1.1 IgG2a antibody inhibitor derived from host mouse.

HY-157743

SCH 60057	Neurokinin Receptor	Neurological Disease
SCH 60057 (Compound 7) is a neurokinin (NK) receptor inhibitor that can be isolated from Acremonium sp., with IC₅₀ values of 6 μM and 12 μM for NK₁ and NK₂, respectively .

HY-173102S

LQEEIDAVL(Pro-13C5,15N)NK TFA	Isotope-Labeled Compounds	Others
LQEEIDAVL(Pro- ¹³C₅, ¹⁵N)NK TFA is the ¹³C- and ¹⁵N-labeled LQEEIDAVL(Pro)NK TFA.

HY-109171

Elinzanetant NT-814; BAY3427080	Neurokinin Receptor	Cardiovascular Disease Neurological Disease
Elizanetant (NT-814) is an orally active, selective *NK-1,3* receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women .

HY-109171R

Elinzanetant (Standard)	Neurokinin Receptor	Cardiovascular Disease Neurological Disease
Elinzanetant (Standard) is the analytical standard of Elinzanetant. This product is intended for research and analytical applications. Elizanetant (NT-814) is an orally active, selective *NK-1,3* receptor antagonist. Elizanetant can reduce the levels of estradiol and progesterone, and is used in the study of vascular motor symptoms and sleep disorders related to menopause in women .

HY-Y0493

HODHBt HOOBt	STAT HIV	Infection Cancer
HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-113008B

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Endogenous Metabolite	Inflammation/Immunology
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

HY-137295

Ingenol 3,20-dibenzoate	PKC Apoptosis	Inflammation/Immunology
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

HY-14406A

L-733060 hydrochloride	Neurokinin Receptor	Neurological Disease Cancer
L-733060 hydrochloride is a potent tachykinin NK₁ receptor antagonist. L-733060 hydrochloride inhibits neurogenic plasma extravasation at doses that do not cause adverse cardiovascular effects in rodents and also acts as an antitumoral agent .

HY-P99752

Nemvaleukin alfa ALKS 4230; RDB-1450	Interleukin Related	Inflammation/Immunology Cancer
Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer .

HY-P990017

Englumafusp alfa CD19-4-1BBL; RO7227166; RG6076	CD19	Cancer
Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion construct comprised of a CD19-specific antibody domain fused to a trimerized extracellular domains of human 41BBL. Englumafusp alfa promotes CD19-specific 4-1BB cross-linking on the surface of T and NK cells .

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective *NK-2* (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity .

HY-P4032

HCV Peptide (35-44)	HCV	Inflammation/Immunology
HCV Peptide (35-44), a HCV core protein at positions 35 to 44, is a HLA-A2-restricted CTL epitope. HCV Peptide (35-44) inhibits NK cell activity via two distinct mechanisms, directly via KIR2DL2/3, and synergistically via the CD94:NKG2A receptor .

HY-151413

MEN 10207	Neurokinin Receptor	Neurological Disease
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.

HY-105346

WIN 51708	Neurokinin Receptor	Neurological Disease
WIN 51708 is a nonpeptide antagonist of neurokinin (NK)-1 receptor. WIN 51708 has a higher affinity for the rat NK-1 receptor compared to the human NK-1 receptor .

HY-116958

SCH 206272	Neurokinin Receptor	Inflammation/Immunology
SCH 206272 is a selective antagonist of the tachykinin (NK) receptor. SCH 206272 inhibits binding at human tachykinin NK(1), NK(2), and NK(3) receptors (K_i = 1.3, 0.4, and 0.3 nM, respectively). SCH 206272 has an orally active .

HY-P10599

Scyliorhinin I	Neurokinin Receptor	Neurological Disease
Scyliorhinin I is a tachykinin-1 (NK-1) and tachykinin-2 (NK-2) receptor agonist with a K_i value of 0.9 nM for rat submandibular gland NK-1 receptor and 2 nM for hamster bladder NK-2 receptor. Scyliorhinin I has the ability to contract the longitudinal muscles of the guinea pig ileum .

HY-129296

YM-44781 free acid	Endogenous Metabolite	Neurological Disease
YM-44781 free acid is a non-peptide neuropeptide receptor antagonist with efficient NK(2) and NK(1) receptor antagonist activity. YM-44781 exhibits significant binding affinity on the NK(2) receptor (pK_i = 9.94) and also on the NK(1) receptor Higher binding affinity (pK_i = 9.09). In addition, YM-44781 also showed significant inhibitory effects on bladder contraction induced by selective NK(1) receptor agonists .

HY-P3802

[D-Trp2,7,9] Substance P	Neurokinin Receptor	Neurological Disease
[D-Trp2,7,9] Substance P is a tachykinin (Neurokinin Receptor) antagonist with K_i values of 1 μM, 1.3 μM, and ~9 μM for *NK-1, NK-2*,and *NK-3* receptor, respectively .

HY-101249

L-732138	Neurokinin Receptor	Neurological Disease Cancer
L-732138 is a selective, potent and competitive neurokinin-1 (NK-1) receptor antagonist with an IC₅₀ of 2.3 nM. L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors, and has > 1000-fold more potent than human NK-2 and NK-3 receptors. L-732138 can reduce hyperalgesia and has antitumor action .

HY-P1276

Men 10376 Neurokinin-2 receptor antagonist	Neurokinin Receptor	Endocrinology
Men 10376 is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor.

HY-P1276A

Men 10376 TFA 1 Publications Verification Neurokinin-2 receptor antagonist TFA	Neurokinin Receptor	Endocrinology
Men 10376 TFA is a selective tachykinin NK-2 receptor antagonist, with a K_i of 4.4 μM for rat small intestine NK-2 receptor .

HY-117053

ZM 253270	Neurokinin Receptor	Neurological Disease
ZM 253270 is a species-selective non-peptide *NK-2* receptor (NK-2R) antagonist. ZM 253270 competitively inhibits the binding of [ ³H]NKA to native or cloned *NK-2R* from hamster bladder (K_i=2 nM), but has a weaker inhibitory effect (48-fold) on the binding of [ ³H]NKA to cloned human *NK-2R* .

HY-169005

Cbl-b-IN-27	E1/E2/E3 Enzyme	Inflammation/Immunology
Cbl-b-IN-27 is a casitas B-lymphoma proto-oncogene-b (Cbl-b) inhibitor with an IC₅₀ value of 7 nM. Cbl-b-IN-27 is promising for research of effector T cell function, T cell, natural killer (NK) cell and B cell activation regulation .

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective *NK₂* receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

Cat. No.	Product Name	Type

HY-116282

Dextran sulfate sodium salt (MW 5000)

2 Publications Verification

DSS (MW 5000); DXS (MW 5000)

Carbohydrates

Dextran sulfate sodium salt (DSS) (MW 5000) is a polymer of dehydrated glucose with a molecular weight of approximately 5000. DSS with different molecular weights exhibits different biological activities. Dextran sulfate sodium salt (DSS) (MW 5000) is an inhibitor of complement and coagulation pathways, and belongs to the glycosaminoglycans (GAG) family. Dextran sulfate sodium salt (MW 5000) acts as an anticoagulant, antiviral, and anti-lipemic agent. Dextran sulfate sodium salt (MW 5000) stops HIV-1 virus adsorption to host cells. Dextran sulfate sodium salt (MW 5000) prevents NK cell-mediated cytotoxicity. Dextran sulfate sodium salt (MW 5000) inhibits instant blood-mediated inflammatory reaction (IBMIR) .

Cat. No.	Product Name	Target	Research Area

HY-P99143

Anti-Mouse NK1.1 Antibody (PK136)	Neurokinin Receptor	Inflammation/Immunology
Anti-Mouse NK1.1 Antibody is an anti-mouse NK1.1 IgG2a antibody inhibitor derived from host mouse.

HY-P99752

Nemvaleukin alfa ALKS 4230; RDB-1450	Interleukin Related	Inflammation/Immunology Cancer
Nemvaleukin alfa (ALKS 4230) is a IL-2 fusion protein that selectively binds to intermediate-affinity IL-2R. Nemvaleukin alfa is an activator of NK and effector T cells. Nemvaleukin alfa can be used for research of cancer .

HY-P99032

Monalizumab 3 Publications Verification IPH2201	Checkpoint Kinase (Chk) IFNAR	Inflammation/Immunology Cancer
Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC) .

HY-P99408

Oxelumab R 4930; huMAb OX 40L; Ro 49-89991	Interleukin Related	Inflammation/Immunology
Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma .

HY-P9915

Daratumumab 1 Publications Verification Anti-Human CD38, Human Antibody	CD38 ADC Antibody	Inflammation/Immunology Cancer
Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition .

HY-P990017

Englumafusp alfa CD19-4-1BBL; RO7227166; RG6076	CD19	Cancer
Englumafusp alfa (CD19-4-1BBL; RO7227166) is a fusion construct comprised of a CD19-specific antibody domain fused to a trimerized extracellular domains of human 41BBL. Englumafusp alfa promotes CD19-specific 4-1BB cross-linking on the surface of T and NK cells .

HY-P990076

Lorukafusp alfa APN-301; hu14.18-IL2; EMD 273063	Inhibitory Antibodies	Cancer
Lorukafusp alfa (14.18 mAb; hu14.18-IL2) is an immunocytokine consisting of the humanized 14.18 anti-GD2 mAb linked to IL210. Lorukafusp alfa has activity mediated by activation of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity via the binding of hu14.18-IL2 to GD2 on the tumor cell surface, followed by binding to Fc receptors on effector cells along with activation of NK and T cells via IL2 receptor binding. Lorukafusp alfa has anti-tumor activity .

HY-P990710

Acimtamig AFM13	TNF Receptor	Cancer
Acimtamig (AFM13) is a CD30/CD16A bispecific innate cell engager. Acimtamig binds to the CD16A expressed on natural killer (NK) cells and binds to CD30 on CD30-expressing tumor cells, thereby selectively cross-linking tumor and NK cells. Acimtamig can be used for the study of eripheral T-cell lymphoma (PTCL) .

HY-P991077

Nogapendekin alfa inbakicept ALT-803; N-803; ANKtiva	Interleukin Related	Inflammation/Immunology Cancer
Nogapendekin alfa inbakicept is a IL-15 superagonist that enhances anti-tumor immune responses by activating NK cells and T cells, and is being studied for the treatment of non-muscle-invasive bladder cancer (NMIBC) .

HY-P990046

Tuparstobart Incagn-02385	LAG-3	Inflammation/Immunology
Tuparstobart (Incagn-02385) is an IgG1κ antibody targeting LAG-3. LAG-3 is an immune checkpoint receptor protein mainly expressed on activated T cells, NK cells, B cells and plasmacytoid dendritic cells .

HY-P99013

Codrituzumab 1 Publications Verification GC33; RO5137382	Glycoprotein VI	Cancer
Codrituzumab (GC33) is a humanized monoclonal antibody targeting human GPC3 (glypican-3), with high affinity (K_d of 0.673 nM). GPC3 is an oncofetal protein expressed on the cell surface of hepatocellular carcinoma (HCC). Codrituzumab induces antibody-dependent cellular cytotoxicity (ADCC) and inhibits tumor growth .

HY-P99419

Acasunlimab GEN1046	PD-1/PD-L1	Cancer
Acasunlimab (GEN1046) is a bispecific antibody (bsAb) targeting PD-L1 and 4-1BB. Acasunlimab enhances T-cell and NK-cell function through conditional 4-1BB stimulation while constitutively blocking the PD-1/PD-L1 inhibitory axis. Acasunlimab can be used in research of cancer .

HY-P990719

Efbalropendekin alfa XmAb24306	Interleukin Related	Inflammation/Immunology Cancer
Efbalropendekin Alfa (XmAb24306) is an IL-15/IL-15 receptor alpha complex fused to a heterodimeric Fc domain (IL15/IL15Rα-Fc). Efbalropendekin Alfa increases direct and antibody-dependent cellular cytotoxicity (ADCC)-mediated human natural killer (NK) cell cytotoxicity in vitro .

HY-P990031

Dargistotug M-6223	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting TIGIT (T cell immune receptor with Ig domain and ITIM). TIGIT is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .

HY-P99902

Simlukafusp alfa FAP-IL2v	Interleukin Related	Cancer
Simlukafusp alfa (FAP-IL2v) is an immunocytokine comprising an antibody against fibroblast activation protein α (FAPα) and an IL-2 variant that only binds IL-2Rβγ. Isotype: human IgG1 .

HY-P991095

ALG.APV-527 APV-527; ATOR-1016	Transmembrane Glycoprotein	Cancer
ALG.APV-527 (APV-527) is a bispecific 4-1BB (CD137) and 5T4 antibody. ALG.APV-527 is designed to activate 4-1BB on T and natural killer (NK) cells only when simultaneously bound to 5T4-expressing tumor cells. ALG.APV-527 has a potent antitumor activity .

HY-P99759

Nogapendekin alfa (his tag) IL-15N72D	Interleukin Related	Inflammation/Immunology Cancer
Nogapendekin alfa (his tag), a soluble protein subunit of a human interleukin (IL)-15 variant, is a superagonist of IL-15. Nogapendekin alfa (his tag) promotes the proliferation and viability of immune cells. Nogapendekin alfa (his tag) combines with Inbakicept (HY-P99661) at a ratio of 2:1, to form N-803 (Nogapendekin alfa inbakicept), an IL-15 cytokine antibody fusion protein. N-803 reduces tumor burden by activation of NK cells and CD8 ⁺ T cells .

HY-P99167

Lucatumumab HCD122	TNF Receptor	Cancer
Lucatumumab (HCD122) is a fully human anti-CD40 antagonist monoclonal antibody, which blocks CD40/CD40L-mediated signaling. Lucatumumab efficiently mediates antibody-dependent cell-mediated cytotoxicity (ADCC) and clearance of tumor cells, can be used for refractory lymphomas, CLL and multiple myeloma research .

HY-P99661

Inbakicept	Interleukin Related	Cancer
Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113008B

trans-Urocanic acid (E)-Urocanic acid; trans-UCA	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function .

HY-137295

Ingenol 3,20-dibenzoate	Classification of Application Fields Terpenoids Source classification Diterpenoids Euphorbia esula L. Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	PKC Apoptosis
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

HY-P0201

Substance P Maximum Cited Publications 19 Publications Verification Neurokinin P	Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology	Neurokinin Receptor Endogenous Metabolite
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, *NK1R*).

HY-W011978

N-Acetyl-L-tryptophan	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Mitochondrial Metabolism Neurokinin Receptor Caspase Interleukin Related
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to *NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β* and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases .

HY-N10118

NK007	Infection Alkaloids Structural Classification Cynanchum mongolicum (Maximowicz) Hemsley Pyrrole Alkaloids Classification of Application Fields Source classification Asclepiadaceae Plants Isoquinoline Alkaloids Disease Research Fields	SARS-CoV
NK007 is a novel anti-SARS-CoV-2 agent with an EC₅₀ value of 30 nM.

HY-N1684

20-Deoxyingenol 3-angelate	Structural Classification Terpenoids Source classification Diterpenoids Plants Meliaceae Aglaia elliptifolia	Others
20-Deoxyingenol 3-angelate (DI3A) increases degranulation and interferon-gamma secretion of NK cells. 20-Deoxyingenol 3-angelate enhances NK cell tumoricidal activity .

HY-P0255

Physalaemin	Structural Classification Animals Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields Endocrinology	Neurokinin Receptor
Physalaemin, a non-mammalian tachykinin, binds selectively to neurokinin-1 (NK1) receptor with high affinity.

HY-119552

Acetylaszonalenin LL-S490β	Alkaloids Microorganisms Source classification Indole Alkaloids	Endogenous Metabolite Neurokinin Receptor
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [ ³H]-SP binding to human astrocytoma cells with a K_i of 170 μM .

HY-N11662

Euphoheliosnoid A	Structural Classification Terpenoids Source classification Euphorbia helioscopia L. Diterpenoids Euphorbiaceae Plants	Others
Euphoheliosnoid A (Compound 24) is a diterpenoid that can significantly enhance the killing activity of natural killer (NK) cells towards H1299-luci cells and A549-luci cells at the concentration of 2.5 μM .

HY-118463

Benzomalvin A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Source classification Quinoline Alkaloids Endogenous metabolite	Neurokinin Receptor
Benzomalvin A is a potent antagonist of neurokinin receptor isolated from Penicillium sp. Benzomalvin A shows inhibitory activity against substance P with K_i values of 12, 42 and 43 μM at the guinea pig, rat and human neurokinin NK1 receptors, respectively .

HY-116620

Benzomalvin C	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Neurokinin Receptor
Benzomalvin C is a weak antagonist of the neurokinin-1 (NK1) receptor inhibiting binding of substance P by 46% when used at 100 μg/mL in vitro. It is also a weak inhibitor of indolamine 2,3-dioxygenase (IDO) with an IC₅₀ value of 130 μM for recombinant IDO. It is isolated from Penicillium and contains an epoxide group at C-19 and C-20, which is not present in benzomalvins A, B, or E.

HY-B0722

Histamine dihydrochloride 5+ Cited Publications	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species
Histamine dihydrochloride is a reactive oxygen species (ROS) inhibitor. Histamine dihydrochloride can suppress ROS production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histamine dihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-B0722R

Histamine (dihydrochloride) (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite Reactive Oxygen Species
Histamine (dihydrochloride) (Standard) is the analytical standard of Histamine (dihydrochloride). This product is intended for research and analytical applications. Histamine dihydrochloride is a reactive oxygen species (ROS) inhibitor. Histamine dihydrochloride can suppress ROS production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histamine dihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma .

HY-N7075

Inulin 2 Publications Verification	Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Compositae Endogenous metabolite Sophora tomentosa L. Human Gut Microbiota Metabolites Polysaccharides Microorganisms Disease Research Fields Saccharides	Endogenous Metabolite
Inulin is a prebiotic targeting the intestinal microbiota, selectively promoting the proliferation and activity of beneficial bacteria such as bifidobacteria and lactic acid bacteria, and playing a role in regulating the intestinal microecology. The functions of Inulin include: ① Fermentation by probiotics in the colon to produce short-chain fatty acids (such as butyrate and propionate), lowering the intestinal pH and inhibiting the overgrowth of harmful bacteria; ② Enhancing the intestinal barrier function and reducing endotoxin translocation; ③ Directly scavenging free radicals (such as superoxide free radicals, hydroxyl free radicals) and activating antioxidant enzymes (SOD, CAT) to reduce oxidative stress. Inulin can also be used in the study of intestinal diseases (constipation, IBD), metabolic syndrome (diabetes, obesity) and liver damage by regulating glucose and lipid metabolism (such as reducing triglycerides, improving insulin sensitivity) and immune response (enhancing NK cell activity, inhibiting inflammatory factors).

Species:	Human (36) Rhesus Macaque (2) Rat (2) Mouse (7) Cynomolgus (3)
Tag:	His (36) Tag Free (2) Avi (11) Myc (1) Fc (12) Flag (2)
Source:	HEK293 (36) CHO (1) Sf9 insect cells (3) P. pastoris (2) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P70551

	NKG2A Protein, Human (HEK293, His) NKG2-A/NKG2-B type II integral membrane protein; CD159 antigen-like family member A; NK cell receptor A; NKG2-A/B-activating NK receptor; CD159a; KLRC1; NKG2A	Human	HEK293
	The NKG2A protein is an important immunosuppressive receptor that forms a complex with KLRD1 on lymphocyte subsets for self-non-self discrimination. It recognizes HLA-E loaded with self-peptides, monitors MHC class I expression in healthy cells, and promotes self-tolerance. NKG2A Protein, Human (HEK293, His) is the recombinant human-derived NKG2A protein, expressed by HEK293 , with N-8*His labeled tag.

HY-P78576

	NKG2A Protein, Cynomolgus/Rhesus macaque (HEK293, His) NKG2A; CD159a; KLRC1; NK cell receptor A	Cynomolgus;Rhesus Macaque	HEK293
	NKG2A Protein, Cynomolgus/Rhesus macaque (HEK293, His) is the recombinant cynomolgus, Rhesus Macaque-derived NKG2A protein, expressed by HEK293 , with N-His labeled tag.

HY-P77106

	NKp30/NCR3 Protein, Rat (HEK293, His) Natural cytotoxicity triggering receptor 3; NK-p30; CD337; NCR3	Rat	HEK293
	NKp30/NCR3 protein is a cell membrane receptor on natural killer (NK) cells that activates cytotoxicity by binding to ligands such as BAG6 and NCR3LG1, stimulating NK cells to respond against neighboring cells (including tumor cells) expressing these ligands. NKp30/NCR3 Protein, Rat (HEK293, His) is the recombinant rat-derived NKp30/NCR3 protein, expressed by HEK293 , with C-His labeled tag. The total length of NKp30/NCR3 Protein, Rat (HEK293, His) is 129 a.a., with molecular weight of ~25-33 KDa.

HY-P78832

	NKp46/NCR1 Protein, Human (Biotinylated, HEK293, His) NCR1; LY94; CD335; NK-p46; hNKp46	Human	HEK293
	NKp46/NCR1 protein, a cytotoxicity-activating receptor on natural killer (NK) cells, potentially enhances their efficacy in tumor cell lysis. Interacting with CD247 and FCER1G, NKp46/NCR1 plays a pivotal role in signaling pathways associated with NK cell activation and cytotoxicity. It contributes to the regulatory network for recognizing and eliminating target cells, emphasizing its importance in immune surveillance and anti-tumor responses. NKp46/NCR1 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293 , with C-His labeled tag. The total length of NKp46/NCR1 Protein, Human (Biotinylated, HEK293, His) is 233 a.a., with molecular weight of 35-45 kDa.

HY-P72018

	NKG2D/CD314 Protein, Human (HEK293, Fc) CD314; CD314 antigen ; D12S2489E; Killer cell lectin like receptor subfamily K member 1; Killer cell lectin-like receptor subfamily K member 1; KLR; KLRC4 KLRK1 readthrough; KLRK1; NK cell receptor D; NK lectin-like receptor; NKG2 D activating NK receptor; NKG2 D type II integral membrane protein; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKg2d; NKG2D_HUMAN; NKLLR; NKR P2; NKrp2	Human	HEK293
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells.It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses.NKG2D/CD314 Protein, Human (HEK293, Fc) is the recombinant human-derived NKG2D/CD314 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77809

	NKG2C/CD159c Protein, Cynomolgus (HEK293, His) CD159c; KLRC2; NKG2C; NK cell receptor C	Cynomolgus	HEK293
	The NKG2C/CD159c protein is an immune-activating receptor that plays a critical role in self-non-self discrimination. It cooperates with KLRD1 to recognize non-classical MHC class Ib HLA-E loaded with HLA-G peptides, affecting adaptive NK cell function and maternal-fetal tolerance. NKG2C/CD159c Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived NKG2C/CD159c protein, expressed by HEK293 , with N-His labeled tag. The total length of NKG2C/CD159c Protein, Cynomolgus (HEK293, His) is 138 a.a., with molecular weight of 25-30 kDa.

HY-P700800

	NKG2C/CD159c Protein, Human (HEK293, hFc) CD159c; KLRC2; NKG2C; NK cell receptor C	Human	HEK293
	The NKG2C/CD159c protein is an immune-activating receptor that plays a critical role in self-non-self discrimination. It cooperates with KLRD1 to recognize non-classical MHC class Ib HLA-E loaded with HLA-G peptides, affecting adaptive NK cell function and maternal-fetal tolerance. NKG2C/CD159c Protein, Human (HEK293, hFc) is the recombinant human-derived NKG2C/CD159c protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NKG2C/CD159c Protein, Human (HEK293, hFc) is 134 a.a., with molecular weight of 48-58 kDa.

HY-P700801

	NKG2C/CD159c Protein, Mouse (HEK293, hFc) CD159c; KLRC2; NKG2C; NK cell receptor C	Mouse	HEK293
	The NKG2C/CD159c protein is an immune-activating receptor that critically differentiates self from non-self by forming a complex with KLRD1. It recognizes non-canonical MHC-E loaded with signal sequence-derived peptides from MHC-G molecules and contributes to the generation and effector function of adaptive NK cells, playing a role in maternal-fetal tolerance. NKG2C/CD159c Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived NKG2C/CD159c protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NKG2C/CD159c Protein, Mouse (HEK293, hFc) is 138 a.a., with molecular weight of 52-60 kDa.

HY-P78006

	NKG2C/CD159c Protein, Human (HEK293, His-Avi) CD159c; KLRC2; NKG2C; NK cell receptor C	Human	HEK293
	The NKG2C/CD159c protein is an immune-activating receptor that plays a critical role in self-non-self discrimination. It cooperates with KLRD1 to recognize non-classical MHC class Ib HLA-E loaded with HLA-G peptides, affecting adaptive NK cell function and maternal-fetal tolerance. NKG2C/CD159c Protein, Human (HEK293, His-Avi) is the recombinant human-derived NKG2C/CD159c protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of NKG2C/CD159c Protein, Human (HEK293, His-Avi) is 134 a.a., with molecular weight of 40-55 kDa.

HY-P75940

	NKG2D/CD314 Protein, Rhesus Macaque (sf9, His) NKG2-D type II integral membrane protein; NK cell receptor D; KLRK1	Rhesus Macaque	Sf9 insect cells
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance. It binds to stress-inducing ligands on tumor and virus-infected cells and triggers the innate immune response of NK cells. NKG2D/CD314 Protein, Rhesus Macaque (sf9, His) is the recombinant Rhesus Macaque-derived NKG2D/CD314 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of NKG2D/CD314 Protein, Rhesus Macaque (sf9, His) is 139 a.a., with molecular weight of ~18.3 kDa.

HY-P700799

	NKG2C/CD159c Protein, Human (Biotinylated, HEK293, His-Avi) CD159c; KLRC2; NKG2C; NK cell receptor C	Human	HEK293
	The NKG2C/CD159c protein is an immune-activating receptor that plays a critical role in self-non-self discrimination. It cooperates with KLRD1 to recognize non-classical MHC class Ib HLA-E loaded with HLA-G peptides, affecting adaptive NK cell function and maternal-fetal tolerance. NKG2C/CD159c Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived NKG2C/CD159c protein, expressed by HEK293 , with C-Avi, N-His labeled tag. The total length of NKG2C/CD159c Protein, Human (Biotinylated, HEK293, His-Avi) is 134 a.a., with molecular weight of 35-55 kDa.

HY-P70174

	NKp46/NCR1 Protein, Human (HEK293, Fc) rHuNatural Cytotoxicity Triggering Receptor 1/NCR1, Fc; Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD335; NCR1; LY94;	Human	HEK293
	NKp46/NCR1 Protein is a major NK cell-activating receptor that is involved in the elimination of target cells and recognizing a wide range of tumors, viruses, and bacteria. NKp46 forms microclusters structures at the immune synapse between NK cells and target cells. Over-expression of human NKp46 is correlated with increased accumulation of F-actin mesh at the immune synapse. NKp46 signaling directly regulates the NK lytic immune synapse from early formation to late function. NKp46/NCR1 Protein, Human (HEK293, Fc) is the recombinant human-derived NKp46/NCR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NKp46/NCR1 Protein, Human (HEK293, Fc) is 233 a.a., with molecular weight of ~66.0 kDa.

HY-P70562

	NKp46/NCR1 Protein, Mouse (HEK293, Fc) Activating receptor1; mAR-1; Lymphocyte antigen94; Naturalkiller cell p46-related protein; NK-p46; NKp46; mNKp46	Mouse	HEK293
	NKp46/NCR1 Protein, a cytotoxicity-activating receptor, boosts activated natural killer (NK) cells' efficacy in eliminating tumor cells.Its interaction with CD3Z and FCER1G suggests a potential role in aiding NK cells in recognizing and destroying cancerous cells.NKp46/NCR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived NKp46/NCR1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76512

	NKG2D/CD314 Protein, Human (CHO, Fc) NKG2-D type II integral membrane protein; NK cell receptor D; CD314; KLRK1; D12S2489E	Human	CHO
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses. NKG2D/CD314 Protein, Human (CHO, Fc) is the recombinant human-derived NKG2D/CD314 protein, expressed by CHO , with N-hFc labeled tag. The total length of NKG2D/CD314 Protein, Human (CHO, Fc) is 139 a.a., with molecular weight of 50-64 & 37 KDa, respectively.

HY-P76514

	NKp46/NCR1 Protein, Rat (HEK293, Fc) Activating receptor1; mAR-1; Lymphocyte antigen94; Naturalkiller cell p46-related protein; NK-p46; NKp46; mNKp46	Rat	HEK293
	The NKp46/NCR1 protein is a key cytotoxic activating receptor that increases the efficiency of activated natural killer (NK) cells, particularly in targeting tumor cell lysis. Through interactions with CD3Z and FCER1G, NKp46/NCR1 orchestrates important connections that enhance the ability of NK cells to destroy tumor cells. NKp46/NCR1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived NKp46/NCR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NKp46/NCR1 Protein, Rat (HEK293, Fc) is 239 a.a., with molecular weight of ~65 & 36 KDa, respectively.

HY-P70688

	NKG2D/CD314 Protein, Human (HEK293, His) CD314; KLRK1; CD314 antigen; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K; member 1; KLR; NK cell receptor D; NKG2-D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor; NKG2D	Human	HEK293
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells.It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses.NKG2D/CD314 Protein, Human (HEK293, His) is the recombinant human-derived NKG2D/CD314 protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P76513

	NKG2D/CD314 Protein, Mouse (sf9, Fc) NKG2-D type II integral membrane protein; NK cell receptor D; CD314; KLRK1; D12S2489E	Mouse	Sf9 insect cells
	NKG2D is an activating cell surface receptor that associates selectively with DAP10, an YxxM-bearing adaptor protein.NKG2D/CD314 Protein, Mouse (sf9, Fc) is the recombinant mouse-derived NKG2D/CD314 protein, expressed by Sf9 insect cells , with N-hFc labeled tag.

HY-P702811

	Granzyme K Protein, Human (His) Fragmentin-3; Granzyme-3; NK-tryptase-2 (NK-Tryp-2); GZMK	Human	E. coli
	Granzyme K Protein, Human (His) is the recombinant human-derived Granzyme K, expressed by E. coli , with N-6*His labeled tag. The total length of Granzyme K Protein, Human (His) is 238 a.a.,

HY-P702812

	Granzyme K Protein, Mouse (His, Myc) Fragmentin-3; Granzyme-3; NK-tryptase-2 (NK-Tryp-2); GZMK	Mouse	E. coli
	Granzyme K Protein, Mouse (His, Myc) is the recombinant mouse-derived Granzyme K, expressed by E. coli , with C-Myc, N-10*His labeled tag. The total length of Granzyme K Protein, Mouse (His, Myc) is 238 a.a.,

HY-P78403

	CD160 Protein, Human (HEK293, His-Avi) CD160; BY55; BY55FLJ46513; NK1; NK28	Human	HEK293
	The CD160 protein is found on immune cells and acts as a receptor that transmits stimulatory or inhibitory signals, complexly regulating cell activation and differentiation. It exists in a GPI-anchored and transmembrane form and may initiate different signaling pathways in NK cells and T cells. CD160 Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD160 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P76645

	SLAMF6 Protein, Human (HEK293) SLAM Family Member 6; Activating NK Receptor; NK-T-B-Antigen; NTB-A; CD352; KALIf	Human	HEK293
	SLAMF6 protein is an autoligand receptor in the SLAM family, which is critical for the activation and differentiation of immune cells and coordinates innate and adaptive immune responses. SLAMF6 is regulated by cytoplasmic adapters such as SH2D1A/SAP and/or SH2D1B/EAT-2, and can trigger the cytolytic activity of NK cells, including VAV1 phosphorylation and SH2D1B dependence. SLAMF6 Protein, Human (HEK293) is the recombinant human-derived SLAMF6 protein, expressed by HEK293 , with tag free.

HY-P76646

	SLAMF6 Protein, Human (HEK293, Fc) SLAM Family Member 6; Activating NK Receptor; NK-T-B-Antigen; NTB-A; CD352; KALIf	Human	HEK293
	SLAMF6 protein is an autoligand receptor in the SLAM family, which is critical for the activation and differentiation of immune cells and coordinates innate and adaptive immune responses. SLAMF6 is regulated by cytoplasmic adapters such as SH2D1A/SAP and/or SH2D1B/EAT-2, and can trigger the cytolytic activity of NK cells, including VAV1 phosphorylation and SH2D1B dependence. SLAMF6 Protein, Human (HEK293, Fc) is the recombinant human-derived SLAMF6 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71317

	SLAMF6 Protein, Human (HEK293, His) SLAM Family Member 6; Activating NK Receptor; NK-T-B-Antigen; NTB-A; CD352; SLAMF6; KALI	Human	HEK293
	SLAMF6 protein is an autoligand receptor in the SLAM family, which is critical for the activation and differentiation of immune cells and coordinates innate and adaptive immune responses. SLAMF6 is regulated by cytoplasmic adapters such as SH2D1A/SAP and/or SH2D1B/EAT-2, and can trigger the cytolytic activity of NK cells, including VAV1 phosphorylation and SH2D1B dependence. SLAMF6 Protein, Human (HEK293, His) is the recombinant human-derived SLAMF6 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76076

	SLAMF6 Protein, Mouse (HEK293, His) SLAM Family Member 6; Activating NK Receptor; NK-T-B-Antigen; NTB-A; CD352; SLAMF6; KALI	Mouse	HEK293
	SLAMF6 protein is a self-ligand receptor in the SLAM family, which complexly regulates the activation and differentiation of immune cells through homotypic or heterotypic interactions, affecting innate and adaptive immune responses. It relies on cytoplasmic adapters such as SH2D1A/SAP and/or SH2D1B/EAT-2 for activity control. SLAMF6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SLAMF6 protein, expressed by HEK293 , with C-His labeled tag. The total length of SLAMF6 Protein, Mouse (HEK293, His) is 209 a.a., with molecular weight of ~28-50 kDa.

HY-P72415

	SLAMF6 Protein, Human (HEK293, His-Avi) SLAM Family Member 6; Activating NK Receptor; NK-T-B-Antigen; NTB-A; CD352; SLAMF6; KALI	Human	HEK293
	SLAMF6 protein is an autoligand receptor in the SLAM family, which is critical for the activation and differentiation of immune cells and coordinates innate and adaptive immune responses. SLAMF6 is regulated by cytoplasmic adapters such as SH2D1A/SAP and/or SH2D1B/EAT-2, and can trigger the cytolytic activity of NK cells, including VAV1 phosphorylation and SH2D1B dependence. SLAMF6 Protein, Human (HEK293, His-Avi) is the recombinant human-derived SLAMF6 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of SLAMF6 Protein, Human (HEK293, His-Avi) is 204 a.a., with molecular weight of 35-50 kDa.

HY-P78421

	CD94 Protein, Human (HEK293, His-Avi) CD94; KLRD1; KP43; NK cell receptor	Human	HEK293
	CD94 protein is a key immune receptor for self-non-self discrimination. It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides. It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance. CD94 Protein, Human (HEK293, His-Avi) is the recombinant human-derived CD94 protein, expressed by HEK293 , with N-Avi, N-His labeled tag.

HY-P73884

	IL-32 alpha Protein, Human (HEK293, His) Interleukin-32; IL-32; NK4; TAIF; IL-32 alpha	Human	HEK293
	IL-32 protein is a member of the cytokine family whose expression increases following T cell activation or IL-2-induced NK cell activation. It plays a key role in inducing macrophages to produce TNFα, which contributes to the inflammatory response. IL-32 alphaProtein, Human (HEK293, His) is the recombinant human-derived IL-32 alpha protein, expressed by HEK293 , with C-His labeled tag.

HY-P78097

	CD94 Protein, Human (Biotinylated, HEK293, His-Avi) CD94; KLRD1; KP43; NK cell receptor	Human	HEK293
	CD94 protein is a key immune receptor for self-non-self discrimination. It forms a complex with KLRC1 or KLRC2 on lymphocyte subsets and recognizes HLA-E loaded with self-peptides. It allows cytotoxic cells to monitor MHC class I expression and promote self-tolerance. CD94 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived CD94 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P700462

	IL-12 Protein, Human (HEK293, His, Flag) Cytotoxic lymphocyte maturation factor; CLMF; IL-12; NK cell stimulatory factor; NKSF	Human	HEK293
	IL-12 beta protein is a multifunctional cytokine that serves as a growth factor for activated T cells and NK cells, amplifies the lytic activity of NK/lymphokine-activated killer cells, and induces IFN production by resting peripheral blood mononuclear cells -γ. peripheral blood mononuclear cells). IL-12 Protein, Human (HEK293, His, Flag) is a recombinant protein dimer complex containing human-derived IL-12 beta & IL-12 alpha Heterodimer protein, expressed by HEK293 , with C-10*His, C-Flag labeled tag. IL-12 Protein, Human (HEK293, His, Flag), has molecular weight of 39.7 kDa & 27.2 kDa.

HY-P76061

	Serpin B6b Protein, Mouse (sf9, His) NK13; Serine (Or cysteine) peptidase inhibitor, clade B, member 6B	Mouse	Sf9 insect cells
	Serpin B6b protein is an important member of the serine protease inhibitor family and plays a crucial role as a serine protease inhibitor, regulating proteolytic activity.His research enhances the understanding of cellular processes related to proteolysis and its therapeutic applications.Serpin B6b Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin B6b protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P700022AF

	Animal-Free BMP-13/GDF-6 Protein, Human (His) subunit (CLMF p35); NK cell Stimulating Factor Chain 1	Human	E. coli
	The BMP-13/GDF-6 protein is a key growth factor that regulates retinal protrusions, apoptosis, and dorsal-ventral positional information and is essential for the formation of the retinal tectum pattern. It is integral to the bones and joints of the limbs, skull, fingers and axial skeleton during skeletal development, shaping species-specific skeletal evolution. Animal-Free BMP-13/GDF-6 Protein, Human (His) is the recombinant human-derived animal-FreeBMP-13/GDF-6 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free BMP-13/GDF-6 Protein, Human (His) is 120 a.a., with molecular weight of ~14.50 kDa.This product is for cell culture use only.

HY-P701284

	FITC-Labeled NKG2D/CD314 Protein, Human (HEK293, Fc) NKG2D; CD314; KLRK1; NK cell receptor D	Human	HEK293
	The NKG2D/CD314 protein serves as a key activating and costimulatory receptor in immune surveillance, binding to multiple stress-inducing ligands on tumor and virus-infected cells. It plays a dual role by stimulating NK cells and enhancing T cell activation in CD8(+) T cell-mediated adaptive responses. FITC-Labeled NKG2D/CD314 Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled NKG2D/CD314 protein, expressed by HEK293 , with N-hFc, N-Flag labeled tag. The total length of FITC-Labeled NKG2D/CD314 Protein, Human (HEK293, Fc) is 139 a.a., with molecular weight of 50-70 kDa.

HY-P70114

	B3GAT1 Protein, Human (HEK293, His) rHuGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1/B3GAT1, His; B3GAT1; Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P); CD57; GlcAT-P; HNK1; NK1; NK-1	Human	HEK293
	B3GAT1 Protein is pivotal in L2/HNK-1 carbohydrate epitope biosynthesis on glycoproteins and glycosaminoglycan biosynthesis.Catalyzing substrates like ASOR and asialo-fetuin, its enzymatic function depends on sphingomyelin presence, with stearoyl-sphingomyelin being the most effective.Notably, it exclusively acts on saturated fatty acids in sphingomyelin, showing no reactivity with unsaturated fatty acids, regardless of acyl group length.B3GAT1 Protein, Human (HEK293, His) is the recombinant human-derived B3GAT1 protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P77970

	KIR2DL2/CD158b1 Protein, Human (HEK293, His-Avi) Killer cell immunoglobulin-like receptor 2DL2; CD158 antigen-like family member B1; MHC class I NK cell receptor; NKAT-6; p58 NK receptor CL-43; CD158b1; KIR2DL2; CD158B1; NKAT6	Human	HEK293
	KIR2DL2/CD158b1, found on NK cells, functions as a receptor for HLA-Cw1, Cw3, Cw7, and Cw8 allotypes. Its key role is to inhibit NK cell activity, serving as a regulator to prevent cellular lysis. Interacting with specific HLA-C molecules, KIR2DL2/CD158b1 contributes to the delicate balance of inhibitory signals in the immune system, shaping the responsiveness of NK cells to potential targets. KIR2DL2/CD158b1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived KIR2DL2/CD158b1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of KIR2DL2/CD158b1 Protein, Human (HEK293, His-Avi) is 224 a.a., with molecular weight of 45-50 kDa.

HY-P77971

	KIR2DL2/CD158b1 Protein, Human (Biotinylated, HEK293, His-Avi) Killer cell immunoglobulin-like receptor 2DL2; CD158 antigen-like family member B1; MHC class I NK cell receptor; NKAT-6; p58 NK receptor CL-43; CD158b1; KIR2DL2; CD158B1; NKAT6	Human	HEK293
	KIR2DL2/CD158b1, found on NK cells, functions as a receptor for HLA-Cw1, Cw3, Cw7, and Cw8 allotypes. Its key role is to inhibit NK cell activity, serving as a regulator to prevent cellular lysis. Interacting with specific HLA-C molecules, KIR2DL2/CD158b1 contributes to the delicate balance of inhibitory signals in the immune system, shaping the responsiveness of NK cells to potential targets. KIR2DL2/CD158b1 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived KIR2DL2/CD158b1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of KIR2DL2/CD158b1 Protein, Human (Biotinylated, HEK293, His-Avi) is 224 a.a., with molecular weight of 45-60 kDa.

HY-P700124AF

	Animal-Free IL-32 alpha Protein, Human (His) IL-32alpha; IL-32beta; IL-32delta; IL-32gamma; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd	Human	E. coli
	IL-32 alpha Protein, a cytokine, potentially contributes to innate and adaptive immune responses. It induces TNFA/TNF-alpha and IL8, activating typical cytokine signal pathways, including NF-kappa-B and p38 MAPK. Animal-Free IL-32 alpha Protein, Human (His) is the recombinant human-derived animal-FreeIL-32 alpha protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-32 alpha Protein, Human (His) is 131 a.a., with molecular weight of ~15.72 kDa.This product is for cell culture use only.

HY-P700828

	SLAMF6 Protein, Cynomolgus (HEK293, His) ANK-T-B-antigen; NTB-A; CD352; SLAMF6; KALI; Ly108; NK-T-B-antigen; KALIb; SF2000	Cynomolgus	HEK293
	SLAMF6 protein is a self-ligand receptor in the SLAM family, which complexly regulates the activation and differentiation of immune cells through homotypic or heterotypic interactions, affecting innate and adaptive immune responses. It relies on cytoplasmic adapters such as SH2D1A/SAP and/or SH2D1B/EAT-2 for activity control. SLAMF6 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived SLAMF6 protein, expressed by HEK293 , with C-His labeled tag. The total length of SLAMF6 Protein, Cynomolgus (HEK293, His) is 206 a.a., with molecular weight of 37-50 kDa.

HY-P71823

	KIR2DS1 Protein, Human (P.pastoris, His) KIR2DS1; CD158 antigen-like family member H; MHC class I NK cell receptor Eb6 ActI	Human	P. pastoris
	KIR2DS1, on NK cells, acts as a receptor for specific HLA-C alleles, like w6, without inhibiting NK cell activity. Interacting with the adapter protein TYROBP/DAP12, their collaboration enhances KIR2DS1 stability at the cell surface. This dynamic interplay highlights the intricate regulatory mechanisms associated with KIR2DS1, contributing to the modulation of NK cell responses. KIR2DS1 Protein, Human (P.pastoris, His) is the recombinant human-derived KIR2DS1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of KIR2DS1 Protein, Human (P.pastoris, His) is 224 a.a., with molecular weight of ~34 kDa.

HY-P71815

	KIR2DS3 Protein, Human (P.pastoris, His) KIR2DS3; NKAT7Killer cell immunoglobulin-like receptor 2DS3; MHC class I NK cell receptor; Natural killer-associated transcript 7; NKAT-7	Human	P. pastoris
	KIR2DS3, present on NK cells, selectively recognizes HLA-C alleles. In contrast to inhibitory KIRs, KIR2DS3 lacks inhibitory effects on NK cell activity. Its role is likely in activating or modulating NK cell functions, contributing to the nuanced balance of signals regulating the immune response. KIR2DS3 Protein, Human (P.pastoris, His) is the recombinant human-derived KIR2DS3 protein, expressed by P. pastoris , with N-His labeled tag.

HY-P77901

	OCIL/CLEC2D Protein, Human (HEK293, Fc-Avi) C-type lectin domain family 2 member D; Lectin-like NK cell receptor; Lectin-like transcript 1; LLT-1; CLAX; LLT1; OCIL; CLEC2D	Human	HEK293
	The OCIL/CLEC2D protein acts as a receptor for KLRB1 and protects target cells from natural killer cell-mediated lysis. It not only inhibits osteoclast formation and bone resorption, but also regulates the release of interferon-γ, indicating that it has immune and bone-related regulatory functions. OCIL/CLEC2D Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived OCIL/CLEC2D protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag. The total length of OCIL/CLEC2D Protein, Human (HEK293, Fc-Avi) is 132 a.a., with molecular weight of 68-78 kDa.

HY-P700191AF

	Animal-Free IL-12 beta Protein, Mouse (His) Interleukin-12 subunit beta; IL-12 subunit p40; IL-12B; Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40); NK cell Stimulating Factor Chain 2	Mouse	E. coli
	IL-12 beta protein is a cytokine that acts as a growth factor for activated T cells and NK cells, enhances lytic activity and stimulates IFN-γ production. It combines with IL23A to form IL-23, a cytokine critical in innate and adaptive immunity. Animal-Free IL-12 beta Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-12 beta protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-12 beta Protein, Mouse (His) is 313 a.a., with molecular weight of ~36.60 kDa.This product is for cell culture use only.

HY-P70617

	IL-12 beta Protein, Human (HEK293) Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; IL12B; NKSF2	Human	HEK293
	IL-12 beta Protein, also known as natural killer cell stimulatory factor 2, is a common subunit (p40) of IL-12 and IL-23. IL-12 is a inflammatory factor expressed by activated macrophages, and involves in Th1-type immune response against cancer. IL-12 beta Protein located outside the cell membrane, involves in singalling mediated by Jak-STAT. IL-12 beta Protein consists of 328 amino acids (M1-S328) with a fibronectin type-III domain (237-328 a.a). IL-12 beta Protein, Human (I23-S328) is produced in HEK293 cells with tag free.

HY-P700100AF

	Animal-Free IL-12 beta Protein, Human (His) Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2; IL12B; NKSF2	Human	E. coli
	IL-12 beta protein is a multifunctional cytokine that serves as a growth factor for activated T cells and NK cells, amplifies the lytic activity of NK/lymphokine-activated killer cells, and induces IFN production by resting peripheral blood mononuclear cells -γ. peripheral blood mononuclear cells). Animal-Free IL-12 beta Protein, Human (His) is the recombinant human-derived animal-FreeIL-12 beta protein, expressed by E. coli , with His labeled tag. The total length of Animal-Free IL-12 beta Protein, Human (His) is 306 a.a., with molecular weight of ~35.64 kDa.This product is for cell culture use only.

HY-P70754

	CD300a/LMIR1 Protein, Human (HEK293, Fc-His) CMRF35-like molecule 8; CD300 antigen-like family member A; CMRF-35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; NK inhibitory receptor	Human	HEK293
	CD300a/LMIR1 Protein, an inhibitory receptor, potentially diminishes cytolytic activity in NK cells and suppresses mast cell degranulation. It serves as a negative regulator in MYD88-mediated TLR signaling, activating PTPN6 but not TRIF. Upon tyrosine phosphorylation, CD300a/LMIR1 engages with PTN6/SHP-1, PTPN11/SHP-2, and INPP5D, showcasing its multifaceted involvement in immune regulation and cellular responses. CD300a/LMIR1 Protein, Human (HEK293, Fc-His) is the recombinant human-derived CD300a/LMIR1 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag.

HY-P7794

	CD158d/KIR2DL4 Protein, Human (HEK293, His) rHuCD158d, His; Killer Cell Immunoglobulin-Like Receptor 2DL4; CD158 Antigen-Like Family Member D; KIR-103AS; MHC Class I NK Cell Receptor KIR103AS; CD158d; KIR2DL4; KIR103AS	Human	HEK293
	CD158d/KIR2DL4 Protein, Human (HEK293, His) is a recombinant human CD158d expressed in HEK 293 cells with a His tag at the N-terminus. CD158d/KIR2DL4 Protein is an NK cell-activating receptor with inhibitory potential.

HY-P71595

	CD300LF Protein, Human (His) CD300 antigen like family member; CD300 antigen-like family member F; CD300 molecule like family member f; CD300f; CD300LF; CLM; CLM-1; CLM1; CMRF35-like molecule 1; IGSF; IgSF13; Inhibitory receptor IREM1; IREM; IREM-1; IREM1; Nepmucin; NK inhibitory receptor; NKIR; TREM	Human	E. coli
	The CD300LF protein acts as a multifunctional immunomodulator, acting as an inhibitory receptor on myeloid cells and mast cells. It plays a vital role in immune homeostasis by actively regulating the phagocytosis of apoptotic cells by binding to phosphatidylserine. CD300LF Protein, Human (His) is the recombinant human-derived CD300LF protein, expressed by E. coli , with N-6*His labeled tag.

HY-P78474

	KIR2DL3 Protein, Human (HEK293, His-Avi) cl-6; KIR2DL3; KIRCL23; KIR-K7b; KIR-K7c; MGC129943; NKAT; NKAT2; NKAT-2; NKAT2A; NK-receptor; p58; NKAT2GL183; CD158b; CD158B2; GL183; KIR-023GB; KIR2DS5; NKAT2B	Human	HEK293
	KIR2DL3, found on NK cells, selectively recognizes HLA-C alleles like HLA-Cw1, HLA-Cw3, and HLA-Cw7. Its interaction leads to inhibitory effects, preventing NK cell activity and cell lysis. KIR2DL3's association with ARRB2 underscores its role in cellular signaling pathways, intricately modulating NK cell functions. KIR2DL3 Protein, Human (HEK293, His-Avi) is the recombinant human-derived KIR2DL3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P78166

	KIR2DL3 Protein, Human (Biotinylated, HEK293, His-Avi) cl-6; KIR2DL3; KIRCL23; KIR-K7b; KIR-K7c; MGC129943; NKAT; NKAT2; NKAT-2; NKAT2A; NK-receptor; p58; NKAT2GL183; CD158b; CD158B2; GL183; KIR-023GB; KIR2DS5; NKAT2B	Human	HEK293
	KIR2DL3, found on NK cells, selectively recognizes HLA-C alleles like HLA-Cw1, HLA-Cw3, and HLA-Cw7. Its interaction leads to inhibitory effects, preventing NK cell activity and cell lysis. KIR2DL3's association with ARRB2 underscores its role in cellular signaling pathways, intricately modulating NK cell functions. KIR2DL3 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived KIR2DL3 protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P70354

	KIR2DL3 Protein, Human (HEK293, His) rHuKiller cell immunoglobulin-like receptor 2DL3/KIR2DL3, His; Killer Cell Immunoglobulin-Like Receptor 2DL3; CD158 Antigen-Like Family Member B2; KIR-023GB; Killer Inhibitory Receptor cl 2-3; MHC Class I NK Cell Receptor; NKAT2a; NKAT2b; Natural Killer-Associated Transcript 2; NKAT-2; p58 Natural Killer Cell Receptor Clone C	Human	HEK293
	KIR2DL3, found on NK cells, selectively recognizes HLA-C alleles like HLA-Cw1, HLA-Cw3, and HLA-Cw7. Its interaction leads to inhibitory effects, preventing NK cell activity and cell lysis. KIR2DL3's association with ARRB2 underscores its role in cellular signaling pathways, intricately modulating NK cell functions. KIR2DL3 Protein, Human (HEK293, His) is the recombinant human-derived KIR2DL3 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B0144AS1

Pitavastatin-d5 sodium
Pitavastatin-d₅ (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.

HY-13704S

SN-38-d3
SN-38-d₃ is the deuterium labeled SN-38. SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4].

HY-B0144AS

Pitavastatin D4
Pitavastatin-d₄ is deuterium labeled Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.

HY-16346S

Netupitant-d6
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist[1].

HY-11063S1

Fingolimod-d4 hydrochloride
Fingolimod-d₄ (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1].

HY-B0144S

Pitavastatin-d4 hemicalcium

Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

HY-B0005S1

Toremifene-d6 hydrochloride
Toremifene-d6 (Z-Toremifene-d6) hydrochloride is deuterium labeled Toremifene. Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC₅₀ of 0.07 µM and 2.6 µM, respectively .

HY-B0005AS

Toremifene-d6
Toremifene-d₆ is deuterium labeled Toremifene. Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

HY-173102S

LQEEIDAVL(Pro-13C5,15N)NK TFA
LQEEIDAVL(Pro- ¹³C₅, ¹⁵N)NK TFA is the ¹³C- and ¹⁵N-labeled LQEEIDAVL(Pro)NK TFA.

HY-12142S

rac-Vofopitant-d3
rac-Vofopitant-d₃ (rac-GR 205171-d₃) is the deuterium labeled Vofopitant (HY-12142) . Vofopitant is potent *tachykinin NK₁* receptor antagonist, with pK_i*s of 10.6, 9.5, and 9.8 for human, rat and ferret NK₁* receptor, respectively .

HY-11063S

Fingolimod-d4
Fingolimod-d₄ is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1].

HY-10053S

Maropitant-d3
Maropitant-d₃ is the deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting .

HY-10053S1

Maropitant-13C,d3
Maropitant- ¹³C,d₃ is the ¹³C- and deuterium labeled Maropitant. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81073

	NK1R Antibody Neurokinin 1; Neurokinin 1 Receptor; NK 1 receptor; NK 1R; NK1 receptor; NK-1R; NK1R; NKIR; SPR; Substance P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor; Tachykinin receptor 1; Tachykinin receptor 1; TACR1; NK1-R; NK1R	WB, ELISA, IHC-P, IHC-F, FC, ICC/IF	Human, Rat, Guinea Pig
	NK1R Antibody is an unconjugated, approximately 48 kDa, rabbit-derived, anti-NK1R polyclonal antibody. NK1R Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, rat, guinea pig, and predicted: mouse, dog, pig, cow, horse background without labeling.

HY-P81474

	NKX6.1 Antibody (YA1219) NKX6-1; NKX6A; Homeobox protein NKx-6.1; Homeobox protein NK-6 homolog A	IHC-P	Human
	NKX6.1 Antibody (YA1219) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1219), targeting NKX6.1. NKX6.1 Antibody (YA1219) can be used for IHC-P experiment in human background.

HY-P81637

	2B4 Antibody (YA1382) CD244; 2B4; Natural killer cell receptor 2B4; NK cell activation-inducing ligand; NAIL; NK cell type I receptor protein 2B4; NKR2B4; h2B4; CD244	ICC/IF, FC, ELISA	Human
	2B4 Antibody (YA1382) is a mouse-derived non-conjugated IgG antibody (Clone NO.: YA1382), targeting 2B4. 2B4 Antibody (YA1382) can be used for ICC/IF, FC, ELISA experiment in human background.

HY-P81447

	NCR1 Antibody (YA1192) natural cytotoxicity triggering receptor 1; LY94; CD335; NKP46; NK-p46	IHC-P	Human
	NCR1 Antibody (YA1192) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1192), targeting NCR1. NCR1 Antibody (YA1192) can be used for IHC-P experiment in human background.

HY-P83166

	IL-32 Antibody (YA2911) IL-32; IL 32alpha; IL 32beta; IL 32delta; IL 32gamma; IL32; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd	WB	Human
	IL-32 Antibody (YA2911) is a non-conjugated IgG antibody, targeting IL-32, with a predicted molecular weight of 27 kDa (observed band size: 23 kDa). IL-32 Antibody (YA2911) can be used for WB experiment in human background.

HY-P81469

	Nkx2.2 Antibody (YA1214) Homeobox protein NKx 2.2; NK 2 homolog B; NK2 homeobox 2; NKX2 2; NKX22; NKx2b	IHC-P	Human
	Nkx2.2 Antibody (YA1214) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1214), targeting Nkx2.2. Nkx2.2 Antibody (YA1214) can be used for IHC-P experiment in human background.

HY-P82572

	NKX3.1 Antibody (YA2317) NKX3-1; NKX3.1; NKX3A; Homeobox protein NKx-3.1; Homeobox protein NK-3 homolog A	WB, IHC-P	Human
	NKX3.1 Antibody (YA2317) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2317), targeting NKX3.1, with a predicted molecular weight of 26 kDa (observed band size: 32 kDa). NKX3.1 Antibody (YA2317) can be used for WB, IHC-P experiment in human background.

HY-P81727

	NTB-A Antibody (YA1472) NTB-A; SLAMF6; Ly108; NK-T-B-antigen; CD352; KALI	FC, ELISA	Human
	NTB-A Antibody (YA1472) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1472), targeting NTB-A. NTB-A Antibody (YA1472) can be used for FC, ELISA experiment in human background.

HY-P82232

	SLAMF6 Antibody (YA1977) NTB-A; SLAMF6; Ly108; NK-T-B-antigen; CD352; KALI	WB, ICC/IF, IP	Human
	SLAMF6 Antibody (YA1977) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1977), targeting SLAMF6, with a predicted molecular weight of 37 kDa (observed band size: 60 kDa). SLAMF6 Antibody (YA1977) can be used for WB, ICC/IF, IP experiment in human background.

HY-P81501

	KIR2DL3 Antibody (YA1246) KIR2DL3 ; CD158B2, KIRCL23, NKAT2; CD158b2; Killer cell immunoglobulin-like receptor 2DL3 ; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; NKAT2a; NKAT2b; Natural killer-associated transcript 2 (NKAT-2); p58 natural killer cell receptor clone CL-6 (p58 NK receptor CL-6); p58.2 MHC class-I-specific NK receptor	IHC-P	Human
	KIR2DL3 Antibody (YA1246) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1246), targeting KIR2DL3. KIR2DL3 Antibody (YA1246) can be used for IHC-P experiment in human background.

HY-P83008

	IL-12 beta Antibody (YA2753) IL12B; NKSF2; Interleukin-12 subunit beta; IL-12B; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2	WB	Human
	IL-12 beta Antibody (YA2753) is a non-conjugated IgG antibody, targeting IL-12 beta, with a predicted molecular weight of 37 kDa (observed band size: 40 kDa). IL-12 beta Antibody (YA2753) can be used for WB experiment in human background.

HY-P82552

	Thyroid Transcription Factor 1 Antibody (YA2297) NKX2-1; NKX2A; TITF1; TTF1; Homeobox protein NKx-2.1; Homeobox protein NK-2 homolog A; Thyroid nuclear factor 1; Thyroid transcription factor 1; TTF-1	WB, ICC/IF	Human, Hamster
	Thyroid Transcription Factor 1 Antibody (YA2297) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2297), targeting Thyroid Transcription Factor 1, with a predicted molecular weight of 39 kDa (observed band size: 39 kDa). Thyroid Transcription Factor 1 Antibody (YA2297) can be used for WB, ICC/IF experiment in human, hamster background.

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Clonality
Immunogen
Appearance
Isotype
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SwissProt ID
Purity
Formulation
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Cat. No.	Product Name		Classification

HY-105346

WIN 51708		Alkynes
WIN 51708 is a nonpeptide antagonist of neurokinin (NK)-1 receptor. WIN 51708 has a higher affinity for the rat NK-1 receptor compared to the human NK-1 receptor .

Cat. No.	Product Name		Classification

HY-150749A

ODN D-SL03 sodium		CpG ODNs
ODN D-SL03 sodium is a C class CpG oligonucleotides, and can induce stimulate PBMCs to produce high level of IFN-α. ODN D-SL03 sodium can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 sodium also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3' .

HY-150725C

ODN 1585 sodium		CpG ODNs
ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 sodium can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant .

HY-160229

ssRNA40 sodium R-1075 sodium		CpG ODNs
ssRNA40 (sodium) is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. ssRNA40 is a uridine-rich ssRNA derived from the HIV-1 long terminal repeat on activation of NK cells via TLR7/8 ^[1][2].

HY-150741C

ODN 2216 sodium 1 Publications Verification		CpG ODNs
ODN 2216 sodium is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN 2216 sodium induces high amounts of IFN-α and IFN-β. ODN 2216 sodium induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 sodium stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 sodium can activate NK cells and promote IFN-γ production of TCR-triggered CD4 ⁺ T cells .

HY-150749

ODN D-SL03		CpG ODNs
ODN D-SL03 is a C class CpG oligonucleotides, can induce stimulate PBMCs to produce high level of IFN-α. ODN D-SL03 can activate human B cells, NK cells and mononuclear cells and up-regulate expression of CD80, CD86 and HLA-DR on the surface of subsets in human PBMCs. ODN D-SL03 also can inhibit the growth of the tumor. ODN D-SL03 sequence: 5'-tcgcgaacgttcgccgcgttcgaacgcgg-3' .

HY-150725

ODN 1585		CpG ODNs
ODN 1585 is a potent inducer of IFN and TNFα production. ODN 1585 is a potent stimulator of NK (natural killer) function. ODN 1585 increases CD8+ T-cell function, including the CD8+ T cell-mediated production of IFN-γ. ODN 1585 induces regression of established melanomas in mice. ODN 1585 can confer complete protection against malaria in mice. ODN 1585 can be used for acute myelogenous leukemia (AML) and malaria research. ODN 1585 can be used as a vaccine adjuvant .

HY-150741

ODN 2216		CpG ODNs
ODN?2216 is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. ODN?2216 induces high amounts of IFN-α and IFN-β. ODN 2216 induces IFN-α by pDC (plasmacytoid DC) and IL-12 (p40) production by DC (dendritic cells). ODN 2216 stimulates IFN-γ production in peripheral blood mononuclear cells (PBMC), which is indirect and mediated by IFN-α/β. ODN 2216 can activate NK cells and promote IFN-γ production of TCR-triggered CD4 ⁺ T cells .

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