Search Result
Results for "
gram-positive,bacteria
" in MedChemExpress (MCE) Product Catalog:
6
Biochemical Assay Reagents
16
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-N14841
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-
-
- HY-W286362
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Palmitic acid anilide
|
Bacterial
|
Infection
|
Palmitanilide (Palmitic acid anilide) is an antibacterial agent against Gram-positive bacteria. Palmitanilide can electrostatically bind to relevant components in the cell walls of Gram-positive bacteria (such as Bacillus cereus), alter the cell membrane structure, and affect the normal functions of the cells. Palmitanilide is promising for research of infectious diseases caused by Gram-positive bacteria .
|
-
-
- HY-N14539
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-
-
- HY-N14497
-
|
Bacterial
|
Infection
|
Nocardicyclin A is resistant to Gram-positive bacteria, mycobacterium and Nocardia .
|
-
-
- HY-N5172
-
-
-
- HY-N13971
-
|
Bacterial
|
Infection
|
Bamicetin is mainly resistant to Gram-positive bacteria and Mycobacteria .
|
-
-
- HY-N14373
-
-
-
- HY-164003
-
|
Bacterial
|
Infection
|
Dapabutan is an antimicrobial agent with activity against Gram-positive bacteria .
|
-
-
- HY-N14891
-
-
-
- HY-N15396
-
-
-
- HY-126579
-
-
-
- HY-N15085
-
-
-
- HY-N13958
-
-
-
- HY-N14224
-
|
Bacterial
|
Infection
|
Enteromycin has anti-Gram positive bacteria and negative bacteria activity .
|
-
-
- HY-N14230
-
-
-
- HY-N5189
-
-
-
- HY-N14819
-
-
-
- HY-W782391
-
|
Bacterial
|
Others
|
Linolenyl alcohol is an unsaturated alcohol that inhibits Gram-positive bacteria .
|
-
-
- HY-W748035
-
-
-
- HY-N13987
-
-
-
- HY-N13972
-
-
-
- HY-N13952
-
-
-
- HY-N13985
-
-
-
- HY-N13969
-
-
-
- HY-N15100
-
-
-
- HY-N13983
-
-
-
- HY-N14964
-
-
-
- HY-N13956
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-
-
- HY-169506
-
-
-
- HY-N5188
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-
-
- HY-N14412
-
-
-
- HY-N14494
-
|
Bacterial
|
Infection
|
Neoviridogrisein I has been used to resist Gram-positive bacteria and mycoplasma .
|
-
-
- HY-N5174
-
Azet-II
|
Bacterial
|
Infection
|
Azetomycin II (Azet-II) has the effect of anti-Gram positive bacteria .
|
-
-
- HY-N14844
-
-
-
- HY-N14691
-
-
-
- HY-P2047
-
Antibiotic FR-900201
|
Antibiotic
Bacterial
|
Infection
|
Lavendomycin is a peptide antibiotic from Streptomyces. Lavendomycin inhibits Gram-positive bacteria .
|
-
-
- HY-N14651
-
|
Bacterial
|
Infection
|
Glucosylquestiomycin has anti-Gram positive bacteria, negative bacteria and yeast activity .
|
-
-
- HY-116272
-
-
-
- HY-N14489
-
|
Bacterial
Fungal
|
Infection
|
Neocopiamycin A is broad-spectrum resistant to Gram-positive bacteria, yeast and filamentous fungi .
|
-
-
- HY-119067
-
-
-
- HY-N14153
-
|
Bacterial
|
Infection
|
Enaminomycin B has anti-Gram positive bacteria and negative bacteria activity .
|
-
-
- HY-N13890
-
-
-
- HY-N14626
-
|
Bacterial
|
Infection
|
Pelagiomicin C has the activity against Gram-positive bacteria and Gram-negative bacteria .
|
-
-
- HY-N14256
-
-
-
- HY-N13887
-
|
Antibiotic
Bacterial
|
Infection
|
Aerocyanidin is an antibiotic containing an isonitrile group, which is mainly effective against Gram-positive bacteria.
|
-
-
- HY-N14154
-
|
Bacterial
|
Infection
|
Enaminomycin C has weak activity against Gram-positive bacteria and negative bacteria .
|
-
-
- HY-117660
-
U-10149
|
Antibiotic
Bacterial
|
Infection
|
Lincomycin, a lincosamide antibiotic, is an antimicrobial agent used for the research of Gram-positive bacteria infections .
|
-
-
- HY-N15059
-
|
Bacterial
|
Infection
|
Cissetin shows activity against Gram-positive bacteria, including drug-resistant strains .
|
-
-
- HY-N14825
-
|
Antibiotic
Bacterial
|
Infection
|
Erythroskyrine is a heterocyclic antibiotic with weak activity against Gram-positive bacteria such as Staphylococcus aureus .
|
-
-
- HY-N14546
-
|
Bacterial
|
Infection
|
Oxirapentyn has anti-Gram-positive bacteria and Mycobacterium activity, but the antibacterial activity is weak .
|
-
- HY-N14542
-
|
Bacterial
|
Infection
Cancer
|
Oleficin is resistant to Gram-positive bacteria and effective against subcutaneous transplantation of Yoshida sarcoma .
|
-
- HY-N14718
-
|
Antibiotic
Bacterial
|
Infection
|
Porothramycin A is an antibiotic. Porothramycin A has activity against Gram-positive bacteria and anaerobic bacteria .
|
-
- HY-N14727
-
|
Antibiotic
Bacterial
|
Infection
|
Primycin is a macrolide antibiotic. Primycin is active against Gram-positive bacteria, mycobacteria and protozoa .
|
-
- HY-N13900
-
-
- HY-N14433
-
|
Bacterial
|
Infection
|
Fumigatin has anti-Gram-positive bacteria, negative bacteria (weak) and vibrio cholerae activities .
|
-
- HY-N14477
-
|
Bacterial
|
Infection
|
Saframycin Mx2 has anti-Gram-positive bacteria and Gram-negative bacteria effects .
|
-
- HY-N14826
-
-
- HY-N14755
-
|
Bacterial
|
Infection
|
Juvenimicin A2 can resist Gram-positive bacteria and individual Gram-negative bacteria .
|
-
- HY-N14372
-
|
Antibiotic
Bacterial
|
Infection
|
Methymycin is a macrolide antibiotic with activity against Gram-positive bacteria and a few Gram-negative bacteria .
|
-
- HY-126577
-
|
Antibiotic
Bacterial
|
|
Dactylocycline B, an antibiotic, is active against gram-positive bacteria, including tetracycline-resistant bacteria .
|
-
- HY-N6728
-
Fumigacin
|
Bacterial
Antibiotic
|
Infection
|
Helvolic acid (Fumigacin) is an antibiotic isolated from Xylaria sp, active against the Gram-positive bacteria .
|
-
- HY-125395
-
-
- HY-123190
-
-
- HY-P2599
-
-
- HY-105350
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Ostreogrycin B2 ; Vernamycin Bβ
|
Antibiotic
Bacterial
|
Infection
|
Pristinamycin IB (Ostreogrycin B2) is an ester peptide antibiotic with anti-Gram-positive bacteria effects .
|
-
- HY-W011916
-
-
- HY-B0706
-
-
- HY-N14986
-
|
Antibiotic
Bacterial
|
Infection
|
Methylenomycin A is a cyclopentanone derived antibiotic that is effective against both Gram-negative and Gram-positive bacteria .
|
-
- HY-N14445
-
-
- HY-N14025
-
-
- HY-N14478
-
|
Bacterial
|
Infection
|
Saframycin Mx1 has anti-Gram-positive bacteria and Gram-negative bacteria effects .
|
-
- HY-B0706A
-
|
Bacterial
Antibiotic
|
Infection
|
Flomoxef sodium is a oxacephem group antibiotic, with excellent activity against various Gram-positive bacteria .
|
-
- HY-B1150
-
|
Bacterial
SARS-CoV
Antibiotic
|
Infection
Cancer
|
Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency .
|
-
- HY-N14784
-
|
Antibiotic
Bacterial
|
Infection
|
Dechloromycorrhizin A is an antibiotic with weak activity against Gram-positive bacteria, yeasts and mildew, and strong nematocidal activity .
|
-
- HY-112853
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FR-31564
|
Bacterial
Antibiotic
|
Infection
|
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.
|
-
- HY-N12681
-
|
Fungal
|
Infection
|
Phoslactomycin A has weak effect against Gram-positive bacteria, but has strong effect against fungi .
|
-
- HY-124111
-
Antibiotic YC 17
|
Antibiotic
Bacterial
|
Infection
|
10-Deoxymethymycin (Antibiotic YC 17) displays antibiotic activity against Gram positive bacteria .
|
-
- HY-121473
-
-
- HY-N14246
-
-
- HY-N14469
-
|
Antibiotic
Bacterial
|
Infection
|
Sakyomicin C is a Benzoquinone antibiotic. Sakyomicin C has activity against Gram-positive bacteria and mycobacteria .
|
-
- HY-W748030
-
|
Antibiotic
Bacterial
|
Infection
|
Griseoviridin is an Estopeptide antibiotic. Griseoviridin has anti-Gram positive bacteria, negative bacteria (individual) activity .
|
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- HY-129952
-
|
Bacterial
|
Infection
|
Dihydropleuromutilin is a reduced product of Pleuromutilin, which is active against gram-positive bacteria and shows lower toxicity .
|
-
- HY-W704321
-
|
Bacterial
|
Infection
|
Diploicin is a diphenyl ether lactone compound with anti-gram-positive bacteria activity, which is found in lichens .
|
-
- HY-N15104
-
-
- HY-N14750
-
|
Bacterial
Fungal
|
Infection
|
Emimycin has anti-Gram-positive bacteria, negative bacteria and brewer's yeast and other fungal activities .
|
-
- HY-129280
-
|
Bacterial
|
Infection
|
Janthinocin A has strong activity of anti-Gram-positive bacteria and moderate anti-Gram-negative bacteria .
|
-
- HY-125656
-
Rhodosporin
|
Antibiotic
Bacterial
|
Infection
|
Bostrycin (Rhodosporin) is a new type of red pigment antibiotic that is primarily effective against Gram-positive bacteria .
|
-
- HY-N14719
-
|
Antibiotic
Bacterial
|
Infection
|
Porothramycin B is an antibiotic. Porothramycin B has activity against Gram-positive bacteria and anaerobic bacteria .
|
-
- HY-N14128
-
|
Bacterial
|
Infection
|
Cirramycin B1 has the activity against Gram-positive bacteria, Gram-negative bacteria and mycoplasmas .
|
-
- HY-125618
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T-2636 D
|
Antibiotic
Bacterial
|
Infection
|
Lankacidinol A (T-2636 D) is an antibiotic, and shows antibacterial activity against Gram-positive bacteria .
|
-
- HY-N14987
-
|
Antibiotic
Bacterial
|
Infection
|
Methylenomycin b is a cyclopentanone derived antibiotic that is effective against both Gram-negative and Gram-positive bacteria .
|
-
- HY-N14492
-
|
Bacterial
|
Infection
|
Coumermycin A2 has anti-Gram positive bacteria, negative bacteria, mycobacterium (weak) activity .
|
-
- HY-N14803
-
-
- HY-N12682
-
|
Fungal
|
Infection
|
Phoslactomycin C has weak effect against Gram-positive bacteria, but has strong effect against fungi .
|
-
- HY-126469
-
|
Bacterial
|
Infection
|
Janthinocin B has strong activity of anti-Gram-positive bacteria and moderate anti-Gram-negative bacteria .
|
-
- HY-N14543
-
|
Bacterial
|
Infection
|
Olivomycin A has strong activity against Gram-positive bacteria and weak activity against Gram-negative bacteria .
|
-
- HY-N14714
-
|
Antibiotic
Bacterial
|
Infection
|
Gunacin is a quinone antibiotic. Gunacin has strong activity against Gram-positive bacteria, negative bacteria and mycoplasma .
|
-
- HY-N14759
-
|
Bacterial
|
Infection
|
Matlystatin B is a type IV collagenase inhibitor. Matlystatin B has anti-Gram-positive bacteria effect .
|
-
- HY-168117
-
|
Bacterial
|
Infection
|
HP-101 is a cell-permeable dual-substrate inhibitor of HPPK with activity against Gram-positive bacteria. .
|
-
- HY-N14261
-
|
Antibiotic
Bacterial
|
Infection
|
Angiolam A is an antibiotic found in Angiococcus disciformis. Angiolam A exhibits notable antibacterial activity against Gram-positive bacteria .
|
-
- HY-N13995
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
Serratamolide is a depsipeptide antibiotic. Serratamolide has anti-Gram-positive bacteria, mycobacteria and fungi activity, but the activity is weak .
|
-
- HY-115367
-
|
Antibiotic
Bacterial
|
Infection
|
Aldgamycin G is a macrolide antibiotic active against Gram-positive bacteria and can be isolated from Streptomyces avidinii .
|
-
- HY-N14745
-
|
Antibiotic
Parasite
|
Infection
|
Elaiomycin has activity against Gram-positive bacteria, some anaerobic bacteria, Eimeria tenella, E.acervulina .
|
-
- HY-130471
-
|
Antibiotic
Bacterial
|
Infection
|
Sannamycin C is an aminoglycoside antibiotic. Sannamycin C has weak antibacterial activity against Gram-positive bacteria .
|
-
- HY-121148
-
|
Antibiotic
Bacterial
|
Infection
|
Mutalomycin is a polyether antibiotic. Mutalomycin has anti-Gram-positive bacteria, anti-mycoplasma and anti-coccidial activity .
|
-
- HY-N14653
-
|
Bacterial
|
Infection
|
Glysperin A has anti-Gram positive bacteria and negative bacteria (including aminoglycoside antibiotic resistant bacteria) activity .
|
-
- HY-N12679
-
|
Fungal
|
Infection
|
Phoslactomycin D has weak effect against Gram-positive bacteria, but has strong effect against fungi .
|
-
- HY-N14125
-
|
Bacterial
|
Infection
|
Chloroquinocin has moderate activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) .
|
-
- HY-N12680
-
|
Fungal
|
Infection
|
Phoslactomycin B has weak effect against Gram-positive bacteria, but has strong effect against fungi .
|
-
- HY-N14174
-
|
Antibiotic
Bacterial
|
Infection
|
Epithienamycin A is a carbapenem antibiotic. Epithienamycin A has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .
|
-
- HY-N14998
-
|
Bacterial
Fungal
|
Infection
|
Damavaricin D has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-fungal effects .
|
-
- HY-N12676
-
|
Fungal
|
Infection
|
Phoslactomycin E has weak effect against Gram-positive bacteria, but has strong effect against fungi .
|
-
- HY-101726
-
|
Bacterial
Antibiotic
|
Infection
|
DuP 105 is an orally active oxazolidinone, a new class of synthetic antimicrobial agent with activity against gram-positive bacteria.
|
-
- HY-N12675
-
|
Fungal
|
Infection
|
Phoslactomycin F has weak effect against Gram-positive bacteria, but has strong effect against fungi .
|
-
- HY-N14610
-
|
Bacterial
|
Infection
|
Grahamimycin B has weak activity against Gram-positive bacteria, negative bacteria, cyanobacteria and green algae .
|
-
- HY-N14655
-
|
Bacterial
|
Infection
|
Paulomenol A has the effect of anti-Gram-positive bacteria including Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae and so on .
|
-
- HY-N14613
-
|
Bacterial
|
Infection
|
Rhodomycin B has the activity of anti-Gram-positive bacteria and weak effect on anti-Gram-negative bacteria and fungi .
|
-
- HY-N14768
-
|
Antibiotic
Bacterial
|
Infection
|
O-Demethylpaulomycin A is an antibiotic with antibacterial activity. O-Demethylpaulomycin A can inhibit Gram-positive bacteria, especially Staphylococcus aureus .
|
-
- HY-N15075
-
|
Antibiotic
Bacterial
|
Infection
|
Espinomycin A2 is a sixteen-membered macrolide antibiotic. Espinomycin A2 is active against Gram-positive bacteria .
|
-
- HY-14855B
-
-
- HY-N15082
-
|
Bacterial
Fungal
|
Infection
Cancer
|
Hypnophilin has a variety of activities, including anti-Gram-positive bacteria, negative bacteria, yeast, mold and tumor activities .
|
-
- HY-126629
-
|
Bacterial
|
Infection
|
Antibacterial agent 12, a biaryloxazolidinone analogue, is an antibacterial agent against antibiotic-susceptible and antibiotic-resistant Gram-positive bacteria .
|
-
- HY-N14680
-
|
Bacterial
|
Infection
|
Glysperin C has anti-Gram positive bacteria and negative bacteria (including aminoglycoside antibiotic resistant bacteria) activity .
|
-
- HY-N13892
-
-
- HY-N13884
-
|
Antibiotic
Bacterial
|
Infection
|
Amythiamicin D is a thiopeptide antibiotic that inhibits the growth of many Gram-positive bacteria, but not Gram-negative bacteria such as E.coli .
|
-
- HY-N14787
-
|
Bacterial
|
Infection
Cancer
|
Basidalin has the ability of anti-Gram-positive bacteria, negative bacteria and inhibition of mouse leukemia L-1210 cell.
|
-
- HY-105041
-
-
- HY-126151
-
|
Bacterial
|
Infection
|
Heneicomycin has anti-Gram-positive bacteria, negative bacteria and mycoplasma activities, and has the effect of promoting animal growth .
|
-
- HY-N14674
-
|
Antibiotic
Bacterial
|
Infection
|
Permetin A is a peptide antibiotic. Permetin A has anti-Gram-negative bacteria, Gram-positive bacteria and anaerobic bacteria activity .
|
-
- HY-N14167
-
|
Bacterial
|
Infection
|
Ekatetrone has the activity of anti-Gram-positive bacteria and negative bacteria, especially has strong effect on mycobacterium tuberculosis .
|
-
- HY-125419
-
|
Antibiotic
Parasite
Bacterial
|
Infection
|
Amythiamicin B is a trisubstituted pyridine thiopeptide with antibiotic properties against Gram-positive bacteria and activity against Plasmodium falciparum .
|
-
- HY-N14338
-
|
Antibiotic
Bacterial
|
Infection
|
Sannamycin L is an aminoglycoside antibiotic. Sannamycin L has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .
|
-
- HY-123321
-
|
Antibiotic
Bacterial
|
Infection
|
Sakyomicin A is an antibiotic isolated from Actinomycete strain M-53. Sakyomicin A is active against Gram-positive bacteria .
|
-
- HY-129034
-
|
Bacterial
Antibiotic
|
Infection
|
Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria .
|
-
- HY-129291
-
AM 6201
|
Antibiotic
Bacterial
Fungal
|
Infection
Cancer
|
Reductiomycin is an antibiotic, which exhibits antimicrobial activity against gram positive bacteria and fungi. Reductiomycin exhibits antitumor activity .
|
-
- HY-151567
-
|
Bacterial
|
Infection
|
Antibacterial agent 123 (compound 111) is a potent membrane-disrupting agent to combat antibiotic-resistant Gram-positive bacteria .
|
-
- HY-N15032
-
|
Antibiotic
Bacterial
|
Infection
|
Espinomycin A3 is a sixteen-membered macrolide antibiotic. Espinomycin A3 is active against Gram-positive bacteria .
|
-
- HY-N14327
-
|
Bacterial
|
Infection
|
Ferensimycin B is a polyether antibiotic with anti-Gram-positive bacteria and weak anti-Gram-negative bacteria, fungi and coccidia .
|
-
- HY-N14654
-
|
Bacterial
|
Infection
|
Glysperin B has anti-Gram positive bacteria and negative bacteria (including aminoglycoside antibiotic resistant bacteria) activity .
|
-
- HY-N14695
-
|
Bacterial
|
Infection
|
Korormicin has the effect of resisting Marine Gram-negative bacteria, but not against the marine Gram-positive bacteria and general bacteria .
|
-
- HY-123716
-
|
Antibiotic
Bacterial
|
Infection
|
Rubradirin B is an antibiotic, which inhibits a variety of Gram-positive bacteria and Haemophilus influenza. Rubradirin B affects the ribosome functions .
|
-
- HY-N14488
-
|
Bacterial
Fungal
|
Infection
|
Nemotinic acid has the activity against Gram-positive bacteria, mycobacterium and fungus, and also against Gram-negative bacteria, but the activity is weak .
|
-
- HY-B1222A
-
Antibiotic 6640; Rickamicin
|
Bacterial
Antibiotic
|
Infection
|
Sisomicin is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is highly active against Gram-positive bacteria .
|
-
- HY-N14829
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
Naphthoquinomycin A is an Ansa antibiotic with anti-Gram-positive bacteria and fungi activity, and can inhibit the synthesis of E. coli fatty acids .
|
-
- HY-P5628
-
|
Bacterial
|
Infection
|
Termicin is an antimicrobial peptide from Pseudacanthotermes spiniger. Termicin has anti-gram-positive bacteria, filamentous fungi and yeast activity .
|
-
- HY-B1222
-
|
Bacterial
Antibiotic
|
Infection
|
Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria.
|
-
- HY-118553
-
|
Bacterial
|
Infection
|
Saframycin D has the effect of anti-Gram-positive bacteria. Saframycin D also has weak activity against mycobacteria .
|
-
- HY-N14736
-
|
Bacterial
|
Infection
|
Drosophilin is an antibacterial agent found in fungi, including Drosophilin A, B, C, and D. Drosophilin inhibits the growth of Gram-positive bacteria .
|
-
- HY-N14209
-
|
Antibiotic
Bacterial
|
Infection
|
Epithienamycin D is a carbapenem antibiotic. Epithienamycin D has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .
|
-
- HY-P1699
-
-
- HY-N14301
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Aquayamycin is an angucycline antibiotic. Aquayamycin is active against Gram-positive bacteria, Ehrlich ascites carcinoma, and Yoshida rat sarcoma cells .
|
-
- HY-N13147
-
|
Antibiotic
Bacterial
|
Infection
|
Tetromycin C5 is an antibiotic, that exhibits board-spectrum antibacterial activity against gram-positive bacteria and their drug-resistant bacteria .
|
-
- HY-N13920
-
|
Antibiotic
Bacterial
|
Infection
|
Avilamycin C is an avilamycin-type antibiotic. Avilamycin C has antibacterial activity and can inhibit Gram-positive bacteria .
|
-
- HY-N14487
-
|
Bacterial
Fungal
|
Infection
|
Nemotin has the activity against Gram-positive bacteria, mycobacterium and fungus, and also against Gram-negative bacteria, but the activity is weak .
|
-
- HY-N14210
-
|
Antibiotic
Bacterial
|
Infection
|
Epithienamycin F is a carbapenem antibiotic. Epithienamycin F has anti-Gram-positive bacteria and anti-Gram-negative bacteria activity .
|
-
- HY-N14541
-
|
Bacterial
|
Infection
|
Saframycin B has the effect of anti-Gram-positive bacteria. Saframycin B also has weak activity against mycobacteria .
|
-
- HY-P5592
-
|
Bacterial
|
Infection
|
Temporin B is an antimicrobial peptide against Gram-positive bacteria. Temporin B is less active against Gram-negative bacteria .
|
-
- HY-118234
-
|
Bacterial
|
Others
|
(Rac)-PD 138312 is the racemate of PD 138312. PD 138312 is a potent and orally active antibacterial agent against Gram-positive bacteria .
|
-
- HY-P5592A
-
|
Bacterial
|
Infection
|
Temporin B acetate is an antimicrobial peptide against Gram-positive bacteria. Temporin B acetate is less active against Gram-negative bacteria .
|
-
- HY-N14538
-
|
Bacterial
|
Infection
|
Saframycin E has the effect of anti-Gram-positive bacteria. Saframycin B also has weak activity against mycobacteria .
|
-
- HY-B2094
-
|
Antibiotic
Bacterial
|
Infection
|
Arbekacin, an aminoglycoside antibiotic, exhibits broad antimicrobial activities against not only Gram-positive bacteria but also Gram-negative bacteria .
|
-
- HY-N14587
-
|
Antibiotic
Bacterial
|
Infection
|
Oxypyrrolnitrin is a nitrogen-containing heterocyclic antibiotic. Oxypyrrolnitrin has anti-Gram-positive bacteria, negative bacteria, mycobacterium and fungal effects .
|
-
- HY-N14656
-
|
Bacterial
|
Infection
|
Paulomenol B has the effect of anti-Gram-positive bacteria including Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pneumoniae and so on .
|
-
- HY-N14345
-
|
Antibiotic
Bacterial
|
Infection
|
Marcellomycin is a glycoside and quinone antibiotic. Marcellomycin has anti-Gram-positive bacteria effect, especially has strong effect on streptococcus .
|
-
- HY-16246
-
|
Fungal
|
Infection
|
Haloprogin is a potent antifungal agent. Haloprogin has activity against dermatophytes, Candida spp and a limited number of Gram-positive bacteria .
|
-
- HY-120383
-
Sacromycin; U-4761
|
Antibiotic
Bacterial
|
Infection
|
Amicetin is a potent antibiotic. Amicetin shows antibiotic activities against gram-positive bacteria. Amicetin inhibits protein synthesis .
|
-
- HY-N14380
-
|
Antibiotic
Bacterial
|
Infection
|
Sannamycin K is an aminoglycoside antibiotic. Sannamycin K has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .
|
-
- HY-N14178
-
|
Bacterial
|
Infection
|
Cyclacidin has anti-individual Gram-positive bacteria (subtilis, Gambosia occidentalis) activity, and has inhibitory effect on sarcoma 180 and so on .
|
-
- HY-152090
-
|
Bacterial
Sirtuin
|
Infection
Cancer
|
Antiproliferative agent-17 is an antiproliferative agent. Antiproliferative agent-17 inhibits Gram-positive bacteria and has anticancer activity .
|
-
- HY-N14513
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
Pyrrolomycin A is a pyrrole antibiotic. Pyrrolomycin A has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity .
|
-
- HY-N10081
-
-
- HY-N11408
-
|
Bacterial
|
Infection
|
Bagougeramine A is found in the strain of Bacillus circulans TB-2125. Bagougeramine A has activities against Gram-positive bacteria and negative bacteria .
|
-
- HY-N14396
-
|
Antibiotic
Bacterial
|
Infection
|
Sannamycin F is an aminoglycoside antibiotic. Sannamycin F has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .
|
-
- HY-N14840
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
1-Hydroxysulfurmycin A is an anthracycline antibiotic. 1-Hydroxysulfurmycin A has anti-Gram-positive bacteria and anti-tumor cell activity .
|
-
- HY-N13885
-
|
Antibiotic
Bacterial
Parasite
|
Infection
|
Amythiamicin A is an antimicrobial antibiotic against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA)) and activity against Plasmodium falciparum .
|
-
- HY-N14849
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
1-Hydroxyauramycin A is an anthracycline antibiotic. 1-Hydroxyauramycin A has anti-Gram-positive bacteria and anti-tumor cell activity .
|
-
- HY-P3466
-
-
- HY-N15038
-
|
Antibiotic
Bacterial
|
Infection
|
Haloquinone is a quinone antibiotic. Haloquinone has strong anti-bacterial activity on Halobacteria, and also has effects on Gram-positive bacteria and mycoplasma .
|
-
- HY-N14833
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
Naphthoquinomycin B is an Ansa antibiotic with anti-Gram-positive bacteria and fungi activity, and can inhibit the synthesis of E. coli fatty acids .
|
-
- HY-P2070
-
|
Bacterial
|
Infection
|
Aspartocin D is an analogue of Amphomycin (HY-P3078). Aspartocin D shows antimicrobial activities against Gram-positive bacteria .
|
-
- HY-N14119
-
|
Bacterial
|
Infection
|
Chloropolysporin C has strong activity of anti-Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and enterococcus bacteria .
|
-
- HY-N15106
-
|
Antibiotic
Bacterial
|
Infection
|
11-Deoxy-13-deoxodaunorubicin is an anthracycline antibiotic with anti-Gram-positive bacteria, negative bacteria and tumor activity .
|
-
- HY-127014
-
|
Bacterial
|
Infection
Cancer
|
Julimycin B2 has anti-Gram-positive bacteria and anti-virus activity and it has effects on ehrman ascites carcinoma in mice .
|
-
- HY-N14118
-
|
Bacterial
|
Infection
|
Chloropolysporin B has strong activity of anti-Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and enterococcus bacteria .
|
-
- HY-N13941
-
|
Bacterial
|
Infection
Cancer
|
Baciphelacin is mainly resistant to gram-positive bacteria and has the activity of inhibiting Newcastle disease virus and leukemia P-388 cells .
|
-
- HY-B1150R
-
|
Bacterial
SARS-CoV
Antibiotic
|
Infection
Cancer
|
Clofoctol (Standard) is the analytical standard of Clofoctol. This product is intended for research and analytical applications. Clofoctol is a bacteriostatic antibiotic. Clofoctol is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria. Clofoctol is only functional against Gram-positive bacteria and can penetrate into human lung tissue. Clofoctol is also an inhibitor of prostate cancer. Clofoctol has antiviral potency .
|
-
- HY-N14673
-
|
Antibiotic
Bacterial
|
Infection
|
Helvecardin A is a glycopeptidtic antibiotic. Helvecardin A has strong activity of anti-aerobic and anaerobic Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus .
|
-
- HY-126660
-
Cinerubine A
|
Bacterial
Fungal
Parasite
|
Infection
Cancer
|
Cinerubin A (Cinerubine A) has anti-Gram-positive bacteria, mycobacterium, fungis and amoeba activity, and has strong effect on mouse adenocarcinoma E0771 .
|
-
- HY-133704
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Pyrrolnitrin is an antibiotic isolated from Pseudomonas pyrrocinia. Pyrrolnitrin shows a broad spectrum of antibiotic activity against fungi, yeast and gram-positive bacteria .
|
-
- HY-118021
-
YL-0358M-A
|
Antibiotic
|
Infection
|
Hatomamicin is an alkaloid antibiotic that can be isolated from the culture filtrate of Sucrose Polyspora. Hatomamicin exhibits antibacterial activity against Gram-positive bacteria .
|
-
- HY-125608
-
Lipiarmycin B3
|
Antibiotic
Bacterial
|
Infection
|
Tiacumicin C (Lipiarmycin B3) is an antibiotic with activity against Gram-positive bacteria. Tiacumicin C is employed in research related to bacterial infections .
|
-
- HY-N14572
-
|
Bacterial
|
Infection
Cancer
|
Roseorubicin A has anti-Gram-positive bacteria and mycobacterium effect. Roseorubicin A also inhibits leukaemia L1210 with an IC50 of 0.04 μg/mL .
|
-
- HY-P1720
-
|
Antibiotic
Bacterial
|
Infection
|
Telomycin is a calcium-dependent antibiotic, which can be produced by Streptomyces. Telomycin inhibits gram-positive bacteria, including multidrug-resistant (MDR) pathogens .
|
-
- HY-B2237A
-
|
Bacterial
HIV
|
Infection
|
Lysozyme chloride is a bactericidal enzyme, and it lyses gram-positive bacteria. Lysozyme chloride can also be used for the research of HIV infection and pulmonary emphysema .
|
-
- HY-W780198
-
|
Bacterial
Fungal
|
Infection
|
Endophenazine A has activity against Gram-positive bacteria and filamentous fungi such as mucor and Penicillium. Its weeding ability to Lemna minor is relatively low .
|
-
- HY-N13881
-
|
Antibiotic
Bacterial
Parasite
|
Infection
|
Amythiamicin C is an antimicrobial antibiotic against Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus (MRSA)) and activity against Plasmodium falciparum .
|
-
- HY-107833
-
|
Bacterial
|
Infection
|
A40926, the precursor of Dalbavancin, is a second-generation glycopeptide antibiotic. A40926 inhibits gram-positive bacteria, and is very active against Neisseria gonorrhoeae .
|
-
- HY-W579772
-
|
Bacterial
|
Infection
|
Tetrabutylammonium (nitrite) is a compound with antibacterial activity. Tetrabutylammonium (nitrite) has inhibitory activity against some Gram-negative bacteria and some Gram-positive bacteria .
|
-
- HY-N13877
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Arugomycin, an anthracycline natural product, is antibiotic against Gram-positive bacteria. Arugomycin has potential as an antitumor agent from its ability to intercalate DNA .
|
-
- HY-125512
-
|
Antibiotic
|
Infection
|
Saccharocarcin B is a macrocyclic lactone antibiotic that is active against the Gram-positive bacteria M. luteus and S. aureus as well as the Gram-negative bacteria C. trachomatis.
|
-
- HY-123614
-
|
Bacterial
|
Infection
|
PD 140248 hydrochloride is a quinolone broad-spectrum antibacterial agent with good in vitro bacteriostatic activity, especially having a significant inhibitory effect on Gram-positive bacteria .
|
-
- HY-N14623
-
|
Bacterial
|
Infection
|
Paulomycin B has anti-Gram-positive bacteria effect, and it has inhibitory effect on Staphylococcus aureus resistant to penicillin, Streptomycin, Neomycin and Macrolide antibiotics .
|
-
- HY-N13962
-
|
Bacterial
Fungal
|
Infection
|
Bagremycin A is found in the strain of Streptomyce sp. Tu 4128. Bagremycin A has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans .
|
-
- HY-N15184
-
Pradimicin C
|
Bacterial
Fungal
|
Infection
|
Benanomicin B (Pradimicin C) is an antifungal antibiotic that also has antibacterial activity against two Gram-positive bacteria: Micrococcus luteus and Corynebacterium bovis .
|
-
- HY-P1607
-
-
- HY-116271
-
|
Antibiotic
Bacterial
|
Infection
|
Sperabillin C is an antibacterial antibiotic with activity against both Gram-negative and Gram-positive bacteria, including resistant strains of Pseudomonas aeruginosa and Staphylococcus aureus .
|
-
- HY-N12421
-
Volonomycin A
|
Bacterial
|
Infection
|
Paulomycin A (Volonomycin A) has anti-Gram-positive bacteria effect, and it has inhibitory effect on Staphylococcus aureus resistant to penicillin, Streptomycin, Neomycin and Macrolide antibiotics .
|
-
- HY-P5630
-
|
Bacterial
|
Infection
|
Aeschna defensing is an antimicrobial peptide derived from hemolymph of dragonfly aquatic larvae. Aeschna defensing has strong activity against gram-positive bacteria .
|
-
- HY-N14847
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
1-Hydroxyauramycin B is an anthracycline antibiotic. 1-Hydroxyauramycin B has anti-Gram-positive bacteria and anti-tumor cell activity .
|
-
- HY-W726164
-
|
Antibiotic
Bacterial
|
Infection
|
Gentamicin A is an antibiotic with good antibacterial activity to Gram-positive bacteria and negative bacteria. Gentamicin A has antibacterial activity against most methicillin-sensitive staphylococcus .
|
-
- HY-N14532
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
Pyrrolomycin E is a pyrrole antibiotic. Pyrrolomycin E has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity .
|
-
- HY-N14133
-
|
Bacterial
|
Infection
|
Enaminomycin A has activity against Gram-positive bacteria, Gram-negative bacteria and plant pathogenic fungi (weak), and it has the inhibitory effect of L-1210 .
|
-
- HY-N5187
-
|
Bacterial
Fungal
|
Infection
|
Edeine A1 can inhibit DNA replication and protein biosynthesis, and has anti-Gram-positive bacteria, Gram-negative bacteria, fungi and yeast activities .
|
-
- HY-N14008
-
|
Antibiotic
Bacterial
Fungal
Parasite
|
Infection
|
Carriomycin is an antibiotic that can be isolated from Streptomyces hygroscopicus. Carriomycin can inhibit Gram-positive bacteria, mycobacteria, yeasts and fungi, and is also an effective anticoccidial agent .
|
-
- HY-N14475
-
|
Antibiotic
Bacterial
|
Infection
|
Sakyomicin B is a Benzoquinone antibiotic found in the strain of Nocardia sp. M-53. Sakyomicin B has activity against Gram-positive bacteria and mycobacteria .
|
-
- HY-106597
-
|
Antibiotic
Bacterial
|
Infection
|
Pirlimycin, a lincosamide antibiotic, is active against Gram-positive bacteria. Pirlimycin acts by inhibiting bacterial protein synthesis via binding with the 50S subunit of the ribosome .
|
-
- HY-B1282A
-
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Sulfaquinoxaline sodium salt is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections .
|
-
- HY-P1926
-
|
Antibiotic
Bacterial
|
Infection
|
A-54556A (ADEP 1) is an acyldepsipeptide (ADEP) antibiotic. A-54556A shows antibacterial activity against a broad range of Gram-positive bacteria .
|
-
- HY-B1282
-
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections .
|
-
- HY-N15095
-
|
Antibiotic
Bacterial
Parasite
|
Infection
|
Aplasmomycin is a boron-containing macrodiolide antibiotic. Aplasmomycin shows antimicrobial activity against Gram-positive bacteria and exhibits inhibitory activity against plasmodium infections in vivo .
|
-
- HY-111264
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
Naphthomycin B is an antibiotic, which is initially isolated from Streptomyces sp. Naphthomycin B exhibits antimicrobial activities against gram positive bacteria and many fungis .
|
-
- HY-N13981
-
|
Antibiotic
Bacterial
|
Infection
|
Arylomycin B2, an antibiotic, is a potent signal peptidase I (SPase I) inhibitor. Arylomycin B2 has anti-Gram-positive bacteria activities .
|
-
- HY-N14528
-
|
Bacterial
|
Infection
|
Oganomycin A is more stable than cephalosporin and resistant to Gram-positive and negative bacteria. And it is more effective against Gram-negative bacteria than Gram-positive bacteria .
|
-
- HY-N14657
-
|
Bacterial
|
Infection
|
Paulomycin A2 has anti-Gram-positive bacteria effect, and it has inhibitory effect on Staphylococcus aureus resistant to penicillin, Streptomycin, Neomycin and Macrolide antibiotics .
|
-
- HY-106597A
-
|
Bacterial
Antibiotic
|
Infection
|
Pirlimycin hydrochloride, a lincosamide antibiotic, is active against Gram-positive bacteria. Pirlimycin hydrochloride acts by inhibiting bacterial protein synthesis via binding with the 50S subunit of the ribosome .
|
-
- HY-E70250
-
Cryptotackieine
|
Parasite
Bacterial
Fungal
|
Infection
|
Neocryptolepine (Cryptotackieine) has antiplasmodial activity. Neocryptolepine also shows antibacterial activity against Gram-positive bacteria (MIC < 100 μg/mL), and antifungal activity .
|
-
- HY-N14106
-
|
Bacterial
|
Infection
Cancer
|
Cinerubin R has anti-Gram-positive bacteria and inhibition of tumor cell activity, and its inhibition effect on multidrug resistant (MDR) cells is the same as that on protocells .
|
-
- HY-N14675
-
|
Antibiotic
Bacterial
|
Infection
|
Helvecardin B is a glycopeptidtic antibiotic. Helvecardin B has strong activity of anti-aerobic and anaerobic Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus .
|
-
- HY-N14706
-
|
Bacterial
|
Infection
|
Kibdelin A is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .
|
-
- HY-N7151
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
Aurachin D is an antibiotic. Aurachin D inhibits Gram-positive bacteria and a few funguses. Aurachin D blocks NADH oxidation in beef heart submitochondrial particles .
|
-
- HY-19581
-
|
Antibiotic
Bacterial
|
Infection
|
Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria .
|
-
- HY-N14551
-
|
Bacterial
|
Infection
Cancer
|
Roseorubicin B has anti-Gram-positive bacteria and mycobacterium effect. Roseorubicin B also inhibits leukaemia L1210 with an IC50 of 0.06 μg/mL .
|
-
- HY-105841A
-
M 139603
|
Antibiotic
|
Infection
|
Tetronasin (M 139603) sodium is a growth-promoting antibiotic with activity against Gram-positive bacteria. Tetronasin sodium is an oral activity that can be administered in the animal's food or water supply .
|
-
- HY-169810
-
|
Antibiotic
Bacterial
|
Infection
|
PKZ18 is an antibiotic and inhibits bacterial growth, with MIC values of 32-64 μg/mL against most Gram-positive bacteria. PKZ18 inhibits in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria and directly reduces T-box transcriptional read-through of the associated genes. PKZ18 prevents the codon-anticodon reading required for tRNA binding and is refractory to resistance .
|
-
- HY-B1252
-
-
- HY-N14707
-
|
Bacterial
|
Infection
|
Kibdelin B is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .
|
-
- HY-121341
-
Ro 10-5970
|
Bacterial
|
Infection
|
Brodimoprim (Ro 10-5970), a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria .
|
-
- HY-116168
-
|
Antibiotic
Bacterial
|
Infection
|
Aldecalmycin is an antibiotic showing antimicrobial activities against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) with MICs values of 6.25-25 μg/mL .
|
-
- HY-A0086
-
SCH-20569 sulfate
|
Bacterial
Antibiotic
|
Infection
|
Netilmicin (sulfate) (SCH-20569 (sulfate)) is an active aminoglycoside antibiotic against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin.
|
-
- HY-N14710
-
|
Bacterial
|
Infection
|
Kibdelin D is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .
|
-
- HY-N14830
-
|
Antibiotic
Bacterial
|
Infection
|
3-Hydroxyrifamycin S is an Ansa antibiotic. 3-Hydroxyrifamycin S has anti-Gram-positive bacteria and weaker anti-Gram-negative bacteria activity .
|
-
- HY-N14088
-
|
Bacterial
|
Infection
|
Chrysospermin A has antibacterial activities against individual Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Klebsiella pneumoniae and individual yeasts (Ocher echinoderma, saccharomyces cerevisiae) .
|
-
- HY-N6738
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K +-dependent ATPase of E. coli .
|
-
- HY-100528
-
Nanchangmycin A
|
Bacterial
Antibiotic
Flavivirus
|
Infection
|
Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria . Nanchangmycin is a broad spectrum antiviral active against Zika virus .
|
-
- HY-N1307
-
|
Bacterial
|
Infection
|
Sideroxylonal A is an effective marine antifouling agent isolated from Eucalyptus jensenii. Sideroxylonal A has antibacterial activity against the Gram-positive bacteria Staphylococcus aureus and Bacilus subtilis .
|
-
- HY-N14693
-
|
Antibiotic
Bacterial
|
Infection
|
Pluracidomycin B is a carbapenem antibiotic. Pluracidomycin B has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .
|
-
- HY-N13963
-
|
Bacterial
Fungal
|
Infection
|
Bagremycin B is found in the strain of Streptomyce sp. Tu 4128. Bagremycin B has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans .
|
-
- HY-P2331
-
Antibiotic A 3802-IV-3; Gardimycin
|
Antibiotic
|
Infection
|
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.
|
-
- HY-117660R
-
|
Antibiotic
Bacterial
|
Infection
|
Lincomycin (Standard) is the analytical standard of Lincomycin. This product is intended for research and analytical applications. Lincomycin, a lincosamide antibiotic, is an antimicrobial agent used for the research of Gram-positive bacteria infections .
|
-
- HY-B1252A
-
-
- HY-N14529
-
|
Bacterial
|
Infection
|
Oganomycin B is more stable than cephalosporin and resistant to Gram-positive and negative bacteria. And it is more effective against Gram-negative bacteria than Gram-positive bacteria .
|
-
- HY-119968
-
Granaticin A; Litmomycin
|
Bacterial
|
Infection
Cancer
|
Granaticin A inhibits the initial stage of RNA biosynthesis, has anti-Gram-positive bacteria, Mycobacterium (weak) and Vaginal trichomonas activity, but also can inhibit tumor cells .
|
-
- HY-W782391R
-
|
Bacterial
|
Others
|
Linolenyl alcohol (Standard) is the analytical standard of Linolenyl alcohol. This product is intended for research and analytical applications. Linolenyl alcohol is an unsaturated alcohol that inhibits Gram-positive bacteria .
|
-
- HY-N14677
-
|
Bacterial
|
Infection
Cancer
|
Pillaromycin A has anti-mycobacteria, Gram-positive bacteria and Gram-negative bacteria effects, but the effect of anti-Gram-negative bacteria is weak. Pillaromycin A also has antitumor activity .
|
-
- HY-B1459A
-
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus .
|
-
- HY-N14660
-
|
Bacterial
|
Infection
|
Granaticin B inhibits the initial stage of RNA biosynthesis, has anti-Gram-positive bacteria, Mycobacterium (weak) and Vaginal trichomonas activity, but also can inhibit tumor cells .
|
-
- HY-B1459
-
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
Dicloxacillin sodium is a β-lactam antibiotic of the penicillin family. Dicloxacillin sodium against Gram-positive bacteria. Dicloxacillin sodium is active against β-lactamase-producing organisms such as Staphylococcus aureus .
|
-
- HY-N11535
-
ENX IIa
|
Antibiotic
Bacterial
|
Infection
|
Enacyloxin IIa (ENX IIa) is a polyene antibiotic, which has the activity of anti-Gram-positive bacteria and negative bacteria. the activity of anti-fungus is weak, and has no effect on yeast .
|
-
- HY-129914
-
KY-109 free base
|
Bacterial
|
Infection
|
Cefcanel daloxate (KY-109 (free base)) is an orally active cephalosporin prodrug against Gram-positive bacteria and Haemophilus influenzae. Cefcanel daloxate is promising for research of uremia .
|
-
- HY-B0706AR
-
|
Bacterial
Antibiotic
|
Infection
|
Flomoxef (sodium) (Standard) is the analytical standard of Flomoxef (sodium). This product is intended for research and analytical applications. Flomoxef sodium is a oxacephem group antibiotic, with excellent activity against various Gram-positive bacteria .
|
-
- HY-N14091
-
|
Bacterial
|
Infection
|
Chrysospermin D has antibacterial activities against individual Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Klebsiella pneumoniae and individual yeasts (Ocher echinoderma, saccharomyces cerevisiae) .
|
-
- HY-N14202
-
|
Antibiotic
Bacterial
|
Infection
|
Maridomycin V is a macrolide antibiotic. Maridomycin Vhas the activity against Gram-positive bacteria and mycoplasma. Maridomycin V has the effect of protecting Gram-positive bacterial infection mice .
|
-
- HY-B1568A
-
Ambodryl hydrochloride
|
Histamine Receptor
Bacterial
|
Infection
Inflammation/Immunology
|
Bromodiphenhydramine hydrochloride is a potent antihistamine with antimicrobial property. Bromodiphenhydramine hydrochloride inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine hydrochloride can be used for cutaneous allergies research .
|
-
- HY-N14090
-
|
Bacterial
|
Infection
|
Chrysospermin C has antibacterial activities against individual Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Klebsiella pneumoniae and individual yeasts (Ocher echinoderma, saccharomyces cerevisiae) .
|
-
- HY-N14089
-
|
Bacterial
|
Infection
|
Chrysospermin B has antibacterial activities against individual Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis), Klebsiella pneumoniae and individual yeasts (Ocher echinoderma, saccharomyces cerevisiae) .
|
-
- HY-N14709
-
|
Bacterial
|
Infection
|
Kibdelin C2 is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .
|
-
- HY-N14708
-
|
Bacterial
|
Infection
|
Kibdelin C1 is resistant to Gram-positive bacteria and has similar effects against Staphylococcus aureus (including methicillin-resistant strains) as Vancomycin (HY-B0671) .
|
-
- HY-N13292
-
|
Antibiotic
Bacterial
|
Infection
|
Actinorhodin is a blue-pigmented, redox-active microbial secondary metabolite. Actinorhodin is a potent, bacteriostatic, pH-responsive antibiotic. Actinorhodin exhibits antimicrobial activity against Gram-positive bacteria .
|
-
- HY-N10229
-
|
Fungal
|
Infection
|
Harzianum A is a trichothecene compound. Harzianum A has no antibacterial activity against Gram-negative and Gram-positive bacteria, but has antifungal activity. In addition, Harzianum A is cytotoxic to tumor cells .
|
-
- HY-106882
-
MDL 62879
|
Bacterial
Antibiotic
|
Infection
|
GE 2270A (MDL 62879) is an antibiotic. GE 2270A inhibits gram-positive bacteria and anaerobes by inhibiting protein synthesis. GE 2270A can be used for the research of infection .
|
-
- HY-149801A
-
|
Bacterial
|
Infection
|
Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen photosensitizer for simultaneous dual applications of Gram-positive bacteria (G+) detection and treatment. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+) from other bacteria due to its interaction with lipoteichoic acids (LTA). Antibacterial agent 140 chloride also possessed robust antibacterial activity for G+ under light irradiation .
|
-
- HY-N14516
-
|
Bacterial
|
Infection
Cancer
|
Saframycin F has the effect of anti-Gram-positive bacteria. Saframycin F has the effect of inhibiting mouse lymphocyte L-1210 with an ID50 of 0.59 μM .
|
-
- HY-N13910
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Alnumycin is a naphthoquinone antibiotic with a narrow-spectrum antimicrobial activity against Gram-positive bacteria. Alnumycin inhibits the growth of K562 human leukemia cells with an IC50 of 0.53 μg/mL .
|
-
- HY-N14694
-
|
Antibiotic
Bacterial
|
Infection
|
Pluracidomycin C1 is a carbapenem antibiotic. Pluracidomycin C1 has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .
|
-
- HY-N14203
-
|
Antibiotic
Bacterial
|
Infection
|
Maridomycin VI is a macrolide antibiotic. Maridomycin VI has the activity against Gram-positive bacteria and mycoplasma. Maridomycin VI has the effect of protecting Gram-positive bacterial infection mice .
|
-
- HY-N14177
-
|
Bacterial
|
Infection
|
Cyathin A4 has weak activity against Gram-positive bacteria, negative bacteria, actinomycetes and dermatophytes, and has anti-ischemia effect (improving cerebral ischemia in rat model) .
|
-
- HY-N14692
-
|
Antibiotic
Bacterial
|
Infection
|
Pluracidomycin A1 is a carbapenem antibiotic . Pluracidomycin A1 has anti-Gram-positive bacteria and Gram-negative bacteria activity, and has the effect of inhibiting β-lactamase .
|
-
- HY-N14201
-
|
Antibiotic
Bacterial
|
Infection
|
Maridomycin IV is a macrolide antibiotic. Maridomycin IV has the activity against Gram-positive bacteria and mycoplasma. Maridomycin IV has the effect of protecting Gram-positive bacterial infection mice .
|
-
- HY-N5191
-
|
Antibiotic
Bacterial
|
Infection
|
Epidermin is a type A lantibiotic that is a tetracyclic 21-amino-acid peptide. Epidermin exhibits antibiotic activity against many Gram-positive bacteria. Epidermin has a role as a metabolite and an antibacterial agent .
|
-
- HY-B1568
-
Ambodryl
|
Histamine Receptor
Bacterial
|
Infection
Inflammation/Immunology
|
Bromodiphenhydramine (Ambodryl) is a potent antihistamine with antimicrobial property. Bromodiphenhydramine inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine can be used for cutaneous allergies research .
|
-
- HY-N14176
-
|
Bacterial
|
Infection
|
Cyathin A3 has weak activity against Gram-positive bacteria, negative bacteria, actinomycetes and dermatophytes, and has anti-ischemia effect (improving cerebral ischemia in rat model) .
|
-
- HY-N14515
-
|
Bacterial
|
Infection
Cancer
|
Saframycin G has the effect of anti-Gram-positive bacteria. Saframycin G has the effect of inhibiting mouse lymphocyte L-1210 with an ID50 of 0.03 μM .
|
-
- HY-N14398
-
|
Bacterial
|
Infection
|
Sannamycin E is an aminoglycoside antibiotic. Sannamycin E can be found in Streptomyces sannanensis KC-7038. Sannamycin E has weak antibacterial activity against Gram-positive bacteria .
|
-
- HY-N13949
-
|
Antibiotic
Bacterial
|
Infection
|
Seitomycin is an anthraquinone antibiotic. Seitomycin has moderate activity against Gram-positive bacteria such as Staphylococcus aureus and Bacillus subtilis, Gram-negative bacteria such as Escherichia coli and green Streptomyces chlorophyllus .
|
-
- HY-N14200
-
|
Antibiotic
Bacterial
|
Infection
|
Maridomycin II is a macrolide antibiotic. Maridomycin II has the activity against Gram-positive bacteria and mycoplasma. Maridomycin II has the effect of protecting Gram-positive bacterial infection mice .
|
-
- HY-N15334
-
|
NO Synthase
Bacterial
Fungal
Drug Derivative
|
Infection
|
Tricrozarin A is a Naphthazarin (HY-N7526) derivative, which is found in fresh bulbs of Tritonia crocosmaeflora. Tricrozarin A exhibits antimicrobial activity against gram-positive bacteria, fungi, and yeast .
|
-
- HY-N13894
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Auramycin A, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin A also exhibits antitumor activity against P388 and L1210 leukemia in mice .
|
-
- HY-B1596A
-
-
- HY-N14499
-
|
Bacterial
|
Infection
Cancer
|
Saframycin H has the effect of anti-Gram-positive bacteria. Saframycin H has the effect of inhibiting mouse lymphocyte L-1210 with an ID50 of 0.033 μM .
|
-
- HY-100528A
-
Nanchangmycin free acid
|
Bacterial
Antibiotic
Flavivirus
|
Infection
|
Dianemycin (Nanchangmycin free acid), a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria . Nanchangmycin is a broad spectrum antiviral active against Zika virus .
|
-
- HY-118992
-
X 5108; Goldinomycin
|
Antibiotic
Bacterial
|
Infection
|
Aurodox (X 5108) is an antibiotic obtained from a streptomyces variant, Aurodox can against a number of gram-positive bacteria. Aurodox shows a very low toxicity in mice and promoted poultry growth .
|
-
- HY-105387
-
-
- HY-121294
-
X 14547A
|
Antibiotic
|
Infection
|
Indanomycin is an antibiotic of the pyrroloketoindane class, which includes an unusual indane ring structure. It has bactericidal activity against Gram-positive bacteria, with minimum inhibitory concentration (MIC) values of ≤0.2 μg/mL.
|
-
- HY-N7139
-
Benzylpenicillin
|
Antibiotic
Bacterial
|
Infection
|
Penicillin G is a potent penicillinantibiotic. Penicillin G can be used for bacterial infection. Penicillin G has potent activity against all Gram-positive bacteria and Gram-negative cocci .
|
-
- HY-N14617
-
|
Bacterial
|
Infection
Cancer
|
Rhodirubin A has a strong anti-Gram-positive bacteria effect, and also has an effect on Mycobacterium. Rhodirubin A can also prolong the survival time of mice inoculated with leukemia L-1210 .
|
-
- HY-N9720
-
|
Antibiotic
Bacterial
Fungal
Others
|
Infection
|
Herbarin is a quinone antibiotic. Herbarin complex has anti-Gram-positive bacteria, negative bacteria, Citrus Canker xanthomonas, potato early blight, Aspergillus Niger, Decaprous and other fungal activities .
|
-
- HY-D0008
-
|
Bacterial
Fungal
Parasite
|
Infection
|
Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal parasites and fungus. Brilliant green is effective against Gram-positive bacteria .
|
-
- HY-125414
-
|
Antibiotic
Bacterial
|
Infection
|
Lydicamycin is an antibiotic isolated from the fermentation broth of an actinomycete strain identified as Streptomyces lydicus. Lydicamycin is active against Gram-positive bacteria and a certain yeast, but inactive against Gram-negative bacteria .
|
-
- HY-N14916
-
|
Bacterial
|
Infection
Cancer
|
Quinomycin C has a strong effect on Gram-positive bacteria and HeLa cells, and also on some Gram-negative bacteria. Quinomycin B also has a protective effect on mice inoculated with poliovirus .
|
-
- HY-125652
-
|
Antibiotic
|
Infection
|
Macrosphelide A is a macrolide antibiotic. Macrosphelide A inhibits growth of some ascomycetes, basidiomycetes, oomycetes and all four Gram-positive bacteria tested, including the medically important Staphylococcus aureus with a MIC of ≤500 μg/mL .
|
-
- HY-136295
-
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
Quinaldopeptin, a quinomycin antibiotic isolated from the culture of Streptoverticillium album strain, is highly active against Gram-positive bacteria and anaerobes and strongly cytotoxic against cultured B16 melanoma cells .
|
-
- HY-157027
-
|
Fungal
|
Others
|
Antifungal agent 85 (compound 24f) is a potent antibacterial compound with the minimum inhibitory concentration (MIC) values between 2.5 and 10 μM against various Gram-positive bacteria .
|
-
- HY-N14571
-
|
Bacterial
|
Infection
Cancer
|
Quinomycin B has a strong effect on Gram-positive bacteria and HeLa cells, and also on some Gram-negative bacteria. Quinomycin B also has a protective effect on mice inoculated with poliovirus .
|
-
- HY-114798
-
-
- HY-125104
-
|
Antibiotic
Bacterial
|
Infection
|
Mirosamicin is an antibiotic with high antibacterial activity that targets a wide range of gram-positive bacteria and certain Gram-negative bacteria as well as mycoplasma. Mirosamicin can be used for research in the field of food safety monitoring .
|
-
- HY-N13895
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Auramycin B, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin B also exhibits antitumor activity against P388 and L1210 leukemia in mice .
|
-
- HY-B0643
-
LY237216
|
Bacterial
Antibiotic
|
Infection
|
Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis .
|
-
- HY-N14010
-
|
Bacterial
|
Infection
|
Cationomycin inhibits the activity of Gram-positive bacteria and mycobacterium, but has no effect on Gram-negative bacteria, yeast and fungi. The feed containing 50-100 ppm Cationomycin could effectively prevent coccidiosis of chicken .
|
-
- HY-P3916
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
GVLSNVIGYLKKLGTGALNAVLKQ is an antimicrobial peptide with 24-amino acid. GVLSNVIGYLKKLGTGALNAVLKQ can potentially form α-helix. GVLSNVIGYLKKLGTGALNAVLKQ (PGQ) has activity against Gram-negative, Gram-positive bacteria and the yeast Candida albicans .
|
-
- HY-N15029
-
|
Antibiotic
Bacterial
Fungal
Parasite
Adenylate Cyclase
|
Infection
|
Destomycin A is an aminoglycoside antibiotic with antibacterial (Gram-positive bacteria, Gram-negative bacteria), antifungal and anthelmintic activities. Destomycin A inhibits the polypeptide synthesis in cells of Escherichia coli and stimulation of adenylate cyclase in animal tissues .
|
-
- HY-171233
-
|
Bacterial
|
Infection
|
MRSA antibiotic 2 (compound 2) shows MIC of 2 μg/mL for S. aureus (MRSA). MRSA antibiotic 2 selectively target Gram-positive bacteria over Gram-negative bacteria and human cells .
|
-
- HY-129329
-
|
Antibiotic
Bacterial
|
Infection
|
Lankamycin, a macrolide antibiotic, shows moderate antimicrobial activity against several gram-positive bacteria, acting as a synergistic pair with carbocyclic antibiotic Lankacidin C (HY-121412) by binding to the ribosome exit tunnel .
|
-
- HY-P0269
-
Magainin I
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .
|
-
- HY-B1222AR
-
|
Bacterial
Antibiotic
|
Infection
|
Sisomicin (Standard) is the analytical standard of Sisomicin. This product is intended for research and analytical applications. Sisomicin is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is highly active against Gram-positive bacteria .
|
-
- HY-N14619
-
|
Bacterial
|
Infection
Cancer
|
Rhodirubin B has a strong anti-Gram-positive bacteria effect, and also has an effect on Mycobacterium. Rhodirubin B can also prolong the survival time of mice inoculated with leukemia L-1210 .
|
-
- HY-125117
-
|
DNA/RNA Synthesis
Bacterial
|
Infection
Cancer
|
Simocyclinone D8 is an anthracycline antibiotic with antibacterial and antitumor activity against Gram-positive bacteria. Simocyclinone D8 inhibits DNA gyrase and thus has an inhibitory effect on a variety of tumor cell lines .
|
-
- HY-P3365
-
|
Bacterial
|
Inflammation/Immunology
Cancer
|
Cecropin D is an antimicrobial peptide with a MIC of 4.55 μg/mL. Cecropin D is effective against both Gram-negative and Gram-positive bacteria. Cecropin D has antiviral, antifungal, antitumor, and immunomodulatory .
|
-
- HY-P5561
-
|
Antibiotic
Bacterial
|
Infection
|
Aurein 2.2 is a major component of the skin secretion of L.aurea. Aurein 2.2 is an antibiotic with broad-spectrum antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and S. epidermidis .
|
-
- HY-123436
-
|
Antibiotic
Bacterial
|
Infection
|
Sarubicin B is an active product that can be isolated from the culture filtrate of a Streptomyces strain JA 2861. Sarubicin B is a quinone antibiotic that inhibit Gram-positive bacteria and not active against Gram-negative microorganisms .
|
-
- HY-B2237
-
|
Bacterial
HIV
|
Infection
|
Lysozyme from chicken egg white is a bactericidal enzyme, and it lyses gram-positive bacteria.
Lysozyme from chicken egg white can also be used for the research of HIV infection and pulmonary emphysema .
|
-
- HY-167651
-
|
Bacterial
Antibiotic
|
Infection
|
TAN-1057C is a potent antibiotic which exhibits antibacterial activity against Gram-negative and Gram-positive bacteria, including Methicillin (HY-121544)-resistant Staphylococcus aureus .
|
-
- HY-P5708
-
Dermaseptin b2
|
Antibiotic
Fungal
Bacterial
|
Infection
|
Adenoregulin (Dermaseptin b2) is an antimicrobial peptide antibiotic. Adenoregulin is active against Gram-negative and Gram-positive bacteria, yeast and fungi. Adenoregulin also enhances the binding of agonists to the A1 adenosine receptor .
|
-
- HY-P10352
-
|
Bacterial
|
Infection
|
Pediocin PA-1 is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 can be used as a food biopreservative .
|
-
- HY-P10210
-
|
Antibiotic
Bacterial
|
Infection
|
Paenilagicin is a Gram-positive active antibiotic with a unique diphosphorylated prenyl binding mechanism that does not induce drug resistance. Paenilagicin exhibits a MIC value of 2 μg/mL against multidrug-resistant Gram-positive bacteria .
|
-
- HY-14855BR
-
TR-701FA (Standard)
|
Bacterial
Antibiotic
Monoamine Oxidase
|
Infection
|
Tedizolid (phosphate) (Standard) is the analytical standard of Tedizolid (phosphate). This product is intended for research and analytical applications. Tedizolid phosphate (TR-701FA) is a MAO-A and MAO-B inhibitor with activity against Gram-positive bacteria[1].
|
-
- HY-N14365
-
|
Bacterial
|
Infection
|
Sannamycin J is an aminoglycoside antibiotic. Sannamycin J can be found in Streptomyces sannanensis sp. KC-7038. Sannamycin J has weak antibacterial activity against Gram-positive bacteria and Gram-negative bacteria .
|
-
- HY-E70234
-
SrtA
|
Bacterial
|
Others
|
Sortase A, S. aureus (SrtA), a transpeptidase enzyme is present in many Gram-positive bacteria and helps in the recruitment of the cell surface proteins. Sortase A, S. aureus plays an important part in ligation of various molecules on the cell surfaces .
|
-
- HY-105321A
-
PBT 2 hydrochloride
|
Bacterial
|
Neurological Disease
|
PBT 1033 hydrochloride is an orally active copper/zinc ionophore. PBT 1033 hydrochloride restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .
|
-
- HY-N14095
-
|
Bacterial
HIV
|
Infection
Cancer
|
Curromycin A has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin A can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .
|
-
- HY-P10219
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
Brevicidine analog 22 (22) exerts broad spectrum antimicrobial activity and excellent stability (t1/2 = 40.98 h), with MICs of 2-16 μM for gram-negative and gram-positive bacteria .
|
-
- HY-169079
-
|
Bacterial
|
Infection
|
RNAP-NusG-IN-1 is an RNAP-NusG inhibitor. RNAP-NusG-IN-1 has antibacterial activity against Gram-positive bacteria, with the strongest activity against Streptococcus pneumoniae, showing an MIC value of 1 μg/mL .
|
-
- HY-B1466A
-
BAY-f 1353
|
Antibiotic
Bacterial
|
Infection
|
Mezlocillin (BAY-f 1353) is a β-lactam antibiotic, a semisynthetic and extended-spectrum antibiotic. Mezlocillin is active against both gram-negative and gram-positive bacteria. Mezlocillin can be used in bacterial infection research .
|
-
- HY-19581S
-
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
Baquiloprim-d6 is deuterium labeled Baquiloprim. Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria[1][2].
|
-
- HY-B1282S
-
|
Isotope-Labeled Compounds
Bacterial
Parasite
Antibiotic
|
Infection
|
Sulfaquinoxaline-d4 is the deuterium labeled Sulfaquinoxaline. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].
|
-
- HY-173080
-
|
Bacterial
|
Infection
|
Antibacterial agent 267 (Compound h19) is a pleuromutilin derivative with a potent antibacterial activity on Gram-positive bacteria. Antibacterial agent 267 shows an antibacterial activity in methicillin-resistant Staphylococcus aureus (MRSA)-infected mouse models .
|
-
- HY-P2020
-
|
Bacterial
|
Infection
|
Berninamycin A is a cyclic thiopeptide antibiotic first isolated from S. bernensis. It inhibits protein biosynthesis in Gram positive bacteria through binding with ribosomal subunits. Cyclic thiopeptide antibiotics, including berninamycin A, induce the transcriptional activator TipA in Streptomyces.
|
-
- HY-149095
-
|
Bacterial
|
Infection
|
Antibacterial agent 139 has antibacterial activity against Gram-positive bacteria. Antibacterial agent 139 has anti-MRSA, anti-VISA, and anti-LRSE activities. Antibacterial agent 139 depolarizes the bacterial cell membrane .
|
-
- HY-B1466
-
BAY-f 1353 sodium
|
Bacterial
Antibiotic
|
Infection
|
Mezlocillin (BAY-f 1353) sodium is a β-lactam antibiotic, a semisynthetic and extended-spectrum antibiotic. Mezlocillin sodium is active against both gram-negative and gram-positive bacteria. Mezlocillin sodium can be used in bacterial infection research .
|
-
- HY-108191
-
Antibiotic 273a1α
|
Bacterial
Antibiotic
|
Infection
|
Paldimycin A (Antibiotic 273a1α) is an antibiotic derived from Streptomyces paulus, primarily targeting Gram-positive bacteria. Paldimycin A exerts its antibacterial effects by interfering with bacterial protein synthesis and cell membrane function .
|
-
- HY-N14652
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Glycocinnasperimicin D is a glycoside cinnamyl imide histamine antibiotic. Glycocinnasperimicin D has the activity of anti-Gram positive bacteria and negative bacteria. Glycocinnasperimicin D inhibits leukemia L1210 cell with an IC50 of 2.0 μg/mL .
|
-
- HY-P10352A
-
|
Bacterial
|
Infection
|
Pediocin PA-1 TFA is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 TFA can be used as a food biopreservative .
|
-
- HY-118951
-
|
Bacterial
|
Infection
|
VU0038882 is a small-molecule activator of coproporphyrinogen oxidase (CgoX). VU0038882 can activate CgoX from Gram-Positive bacteria in vitro. VU0038882 can be used for the research of skin and soft tissue infections (SSTIs) .
|
-
- HY-N6748
-
-
- HY-N14107
-
|
Antibiotic
Bacterial
|
Infection
|
Cinnabarin is an antibiotic which can be extracted from Polystiotus cinnabarinus, P. versicolo and Trametes cinnabarinus. Cinnabarin exhibits antibacterial activity against Gram-positive bacteria as well as antiviral activity, making it a potential candidate for infectious disease research .
|
-
- HY-105321
-
PBT 2
|
Bacterial
|
Neurological Disease
|
PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria .
|
-
- HY-P0269A
-
Magainin I TFA
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Magainin 1 TFA (Magainin I TFA) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 TFA exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .
|
-
- HY-19915A
-
MRX-4
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Contezolid acefosamil (MRX-4) is the orally active proagent of the active antimicrobial metabolite Contezolid (MRX-I), an oxazolidinone which shows potent in vitro activity against various multidrug-resistant Gram-positive bacteria, including MRSA .
|
-
- HY-B1825
-
|
Antibiotic
Bacterial
Beta-lactamase
|
Infection
|
Cefoxitin is a cephalosporin-class antibiotic. Cefoxitin is highly stable against β-Lactamase (HY-P2998). Cefoxitin has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria .
|
-
- HY-N14496
-
|
Bacterial
|
Infection
Cancer
|
Nisamycin has stronger anti-Gram-positive bacteria and weaker anti-fungal and individual Gram-negative bacteria activities. Nisamycin has weak cytotoxic effect. The IC50 of mouse leukemia P388 cells is 4.8 μg/mL .
|
-
- HY-N14608
-
|
Antibiotic
Bacterial
|
Infection
|
Pacidamycin D is a Pacidamycin antibiotic. Pacidamycin D has the activity against Pseudomonas aeruginosa with a MIC of 4-16 μg/mL. it has no effect on other Gram-negative bacteria and Gram-positive bacteria, and no effect on drug-resistant pseudomonas aeruginosa .
|
-
- HY-N14837
-
|
Others
|
Inflammation/Immunology
|
Lymphostin is an immunosuppressant. Lymphostin has inhibitory effects on lymphocyte kinase (IC50 is 0.05 μM), and it also inhibits mixed lymphocyte response (IC50 is 0.009 μM). Lymphostin has no effect on the Gram-positive bacteria and negative bacteria .
|
-
- HY-N15028
-
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
Depsidomycin is an immunomodulatory antibiotic with immunosuppressive activity that can be isolated from the culture broth of Streptomyces lavendofoliae MI951-62F2. Depsidomycin primarily exhibits antibacterial activity against Gram-positive bacteria .
|
-
- HY-B0359
-
REC 15-1476
|
Fungal
Antibiotic
|
Infection
|
Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis .
|
-
- HY-B0977
-
Dicloxacillin sodium salt monohydrate
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus .
|
-
- HY-N13990
-
|
Bacterial
|
Infection
|
Senfolomycin A has the effect of anti-Gram-positive bacteria and mycobacterium, and also has the effect of anti-Staphylococcus aureus resistant to penicillin, Streptomycin, Neomycin, Macrolide antibiotics. Senfolomycin A also has weaker effect of anti-Gram-negative bacteria .
|
-
- HY-N14110
-
|
Bacterial
HIV
|
Infection
|
Curromycin B has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin B can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .
|
-
- HY-P1631
-
|
Bacterial
|
Infection
|
Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against Gram-negative and Gram-positive bacteria. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges .
|
-
- HY-165101
-
10-Methyl dodecanoic acid; FA 13:0
|
Others
|
Others
|
10-Methyl lauric acid (10-Methyl dodecanoic acid) is a alkyl-substituted fatty acid. 10-Methyl lauric acid can be found in the Gram-positive bacteria B. acetylicum, as well as the mandibular gland secretions of carpenter ant species .
|
-
- HY-127093
-
|
Antibiotic
Bacterial
|
Infection
|
Sedecamycin is an antibiotic, which exhibits antibacterial activity against gram-positive bacteria. Sedecamycin inhibits Treponema hyodysenteriae, with MIC of 0.78 to 12.5 µg/ml. Sedecamycin exhibits protective and therapeutic effect against the swine dysentery in mouse models .
|
-
- HY-106597AR
-
|
Bacterial
Antibiotic
|
Infection
|
Pirlimycin (hydrochloride) (Standard) is the analytical standard of Pirlimycin (hydrochloride). This product is intended for research and analytical applications. Pirlimycin hydrochloride, a lincosamide antibiotic, is active against Gram-positive bacteria. Pirlimycin hydrochloride acts by inhibiting bacterial protein synthesis via binding with the 50S subunit of the ribosome .
|
-
- HY-19581R
-
|
Antibiotic
Bacterial
|
Infection
|
Baquiloprim (Standard) is the analytical standard of Baquiloprim. This product is intended for research and analytical applications. Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria .
|
-
- HY-N13991
-
|
Bacterial
|
Infection
|
Senfolomycin B has the effect of anti-Gram-positive bacteria and mycobacterium, and also has the effect of anti-Staphylococcus aureus resistant to penicillin, Streptomycin, Neomycin, Macrolide antibiotics. Senfolomycin A also has weaker effect of anti-Gram-negative bacteria .
|
-
- HY-119604
-
|
Antibiotic
Bacterial
|
Infection
|
Cafamycin is a polyether antibiotic active against gram-positive bacteria, including Staphylococcus aureus. Cafamycin also demonstrates insecticidal and antiprotozoal activities. Cafamycin is isolated from the culture fluid of Streptomyces sp., an organism producing the anthracycline antibiotic galtamycin .
|
-
- HY-130340
-
Teichomycin A3 factor 1; Antibiotic L 17054
|
Antibiotic
|
Infection
|
Teicoplanin A3-1 is a degradation product of teicoplanins A2-1 to 5 (Item Nos. 20187, 20188, 20189, 20192). Teicoplanins are glycopeptide antibiotics produced by A. teichomyceticus that are broadly effective against Gram-positive bacteria in vitro.
|
-
- HY-B1282R
-
|
Bacterial
Parasite
Antibiotic
|
Infection
|
Sulfaquinoxaline (Standard) is the analytical standard of Sulfaquinoxaline. This product is intended for research and analytical applications. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections .
|
-
- HY-N15019
-
|
Antibiotic
Bacterial
|
Infection
|
Glycothiohexide α is a peptide antibiotic. Glycothiohexide α has strong activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VREF), MIC values of 0.03-0.06 μg/mL .
|
-
- HY-N14171
-
|
Bacterial
Fungal
|
Infection
|
Epicorazine A has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine A also has effect on Candida albicans with a MIC of 25 μg/mL .
|
-
- HY-B1252R
-
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
Cefalonium (Standard) is the analytical standard of Cefalonium. This product is intended for research and analytical applications. Cefalonium is the first-generation β-lactam cephalosporin antibiotic that is widely used to research bovine mastitis caused by Gram-positive bacteria including staphylococci .
|
-
- HY-119188
-
|
Bacterial
|
Infection
Cancer
|
Saframycin A has the effect of anti-Gram-positive bacteria. Saframycin A also has weak activity against Gram-negative bacteria and mycobacteria. Saframycin A has the effect of inhibiting mouse lymphocyte L-1210 with an ID50 of 0.0056 μM .
|
-
- HY-17586
-
MDL-63397 hydrochloride; BI-397 hydrochloride
|
Bacterial
Antibiotic
|
Infection
|
Dalbavancin hydrochloride (MDL-63397 hydrochloride) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin hydrochloride inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively .
|
-
- HY-N15420
-
|
Antibiotic
Bacterial
|
Infection
|
Leucomycin A7 is a member of the leucomycin complex that can be isolated from Streptomyces kitasatoensis. Leucomycin A7 has antibacterial activity and has strong inhibitory effects on the growth of Gram-positive bacteria, but weak inhibitory effects on Gram-negative bacteria .
|
-
- HY-17586A
-
MDL-63397; BI-397
|
Bacterial
Antibiotic
|
Infection
|
Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively .
|
-
- HY-157482
-
|
Bacterial
|
Infection
|
EBP-59 is a bacterial inhibitor with antibiofilm activity against Gram-positive bacteria. EBP-59 is effective against Staphylococcus aureus and MRSA (methicillin–resistant staphylococcus aureus). EBP-59 can be used to study bacterial infections .
|
-
- HY-121341R
-
|
Bacterial
|
Infection
|
Brodimoprim (Standard) is the analytical standard of Brodimoprim. This product is intended for research and analytical applications. Brodimoprim (Ro 10-5970), a trimethoprim analogue, is an orally active dihydrofolate reductase inhibitor. Brodimoprim is highly active against a broad spectrum of gram-negative and gram-positive bacteria .
|
-
- HY-114227
-
|
DNA Stain
|
Inflammation/Immunology
|
Hexidium iodide, a fluorescent nucleic binding acid stain (excitation/emission ~ 518/600 nm), permeants to mammalian cells and selectively stains almost all gram-positive bacteria. Hexidium iodide can bind to the DNA of all bacteria after permeabilization by EDTA .
|
-
- HY-W031471A
-
|
Bacterial
Fungal
|
Infection
|
Pyrazine-2-amidoxime is a structural analogue of pyrazine-2-carboxamide with antimicrobial activity. Pyrazine-2-amidoxime shows killing and inhibiting properties against Candida albicans, fungal pathogen and Gram-positive bacteria .
|
-
- HY-114780
-
|
Penicillin-binding protein (PBP)
Bacterial
|
Infection
|
Lactivicin is a non-beta-lactam antibiotic showing beta-lactam action through binding to penicillin-binding protein (PBP). Lactivicin is moderately active against a wide range of Gram-negative bacteria and highly active against Gram-positive bacteria .
|
-
- HY-N14028
-
|
Bacterial
|
Infection
Cancer
|
Coriolin A has anti-Gram-positive bacteria, negative bacteria (weak), yeast and vaginal trichomoniasis activities. Coriolin A of 5 μg/mL can inhibit the growth of yoshida sarcoma 61.6%. Coriolin A has no inhibitory effect on Ehrlich ascites carcinoma in animals .
|
-
- HY-124712
-
|
Bacterial
|
Infection
|
Divin, a potent chelator of iron, is a potent inhibitor of bacterial cell division with bacteriostatic effect in Gram-negative and Gram-positive bacteria. Divin disrupts the assembly of late division proteins, reduces peptidoglycan remodeling at the division site, and blocks compartmentalization of the cytoplasm .
|
-
- HY-B1222R
-
|
Bacterial
Antibiotic
|
Infection
|
Sisomicin (sulfate) (Standard) is the analytical standard of Sisomicin (sulfate). This product is intended for research and analytical applications. Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria [4].
|
-
- HY-B1459AR
-
|
Beta-lactamase
Bacterial
Antibiotic
|
Infection
|
Dicloxacillin (Standard) is the analytical standard of Dicloxacillin. This product is intended for research and analytical applications. Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus .
|
-
- HY-19915
-
MRX-I
|
Bacterial
Antibiotic
Monoamine Oxidase
|
Infection
Inflammation/Immunology
|
Contezolid (MRX-I), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. Contezolid (MRX-I) markedly reduces potential for myelosuppression and monoamine oxidase inhibition (MAOI) .
|
-
- HY-B1354
-
SM-1652 free acid; Wy-44635 free acid
|
Beta-lactamase
Antibiotic
Bacterial
|
Infection
|
Cefpiramide (SM-1652) free acid is a semisynthetic cephalosporin with broad-spectrum antibacterial activity. Cefpiramide free acid shows strong antibacterial effect on both gram-positive bacteria and gram-negative bacteria. Cefpiramide free acid is moderately susceptible to β-lactamase .
|
-
- HY-127155
-
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Kigamicin C is an anti-tumor antibiotic that selectively kills pancreatic cancer PANC-1 cells only in nutrient-poor conditions. Kigamicin C has antimicrobial activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) .
|
-
- HY-130079
-
Penicillin G procaine
|
Bacterial
|
Infection
|
Procaine benzylpenicillin (Penicillin G procaine) is an antimicrobial agent. Procaine benzylpenicillin shows inhibitory activity against gram-positive bacteria and synergistic activity with Neomycin (HY-B0470). Procaine benzylpenicillin can be used in the study of bovine mastitis in animal husbandry .
|
-
- HY-126662
-
|
Bacterial
|
Infection
|
Netzahualcoyone is a triterpenoid compound isolated from the Celastraceae plant family. Netzahualcoyone exhibits broad-spectrum antibiotic activity against Gram-positive bacteria and yeasts, but is not active against Gram-negative bacteria. Netzahualcoyone can be utilized in the development of antibiotics and for studying antimicrobial mechanisms .
|
-
- HY-B1568AR
-
|
Histamine Receptor
Bacterial
|
Infection
Inflammation/Immunology
|
Bromodiphenhydramine (hydrochloride) (Standard) is the analytical standard of Bromodiphenhydramine (hydrochloride). This product is intended for research and analytical applications. Bromodiphenhydramine hydrochloride is a potent antihistamine with antimicrobial property. Bromodiphenhydramine hydrochloride inhibits a large number of Gram negative and Gram positive bacteria. Bromodiphenhydramine hydrochloride can be used for cutaneous allergies research .
|
-
- HY-10394
-
PNU-100766
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics .
|
-
- HY-B1117
-
MK-306
|
Bacterial
Antibiotic
Beta-lactamase
|
Infection
|
Cefoxitin sodium (MK-306) is a cephalosporin-class antibiotic. Cefoxitin sodium is highly stable against β-Lactamase (HY-P2998). Cefoxitin sodium has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria .
|
-
- HY-N14747
-
|
Bacterial
|
Infection
|
Elloramycin has weak activity against Gram-positive bacteria, streptomycete and L-1210 leukemic cells, but has no effect on mouse leukemic P388 cells in vivo, and also has a strong inhibition of Streptomyces (including the production of bacteria themselves) activity .
|
-
- HY-121407
-
|
Acyltransferase
|
Infection
Cancer
|
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188 . Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans .
|
-
- HY-135531
-
|
Antibiotic
Bacterial
|
Infection
|
Cefuzonam is an antibiotic, which exhibits antibacterial activity against gram positive bacteria, such as Staphylococcus, Streptococcus and Neisseria gonorrhoeae, with MIC ranginf from 0.63 to 2 μg/mL. Cefuzonam is an inhibitor for mild steel corrosion by increasing hydrophobicity of the metal surface to the acid solution .
|
-
- HY-19829
-
|
ADC Cytotoxin
Bacterial
Antibiotic
|
Infection
Cancer
|
Sandramycin ia a cyclic depsipeptide antibiotic isolated from cultured broth of a Nocardioides sp. Sandramycin is also a DNA intercalator that potently binds DNA and is an ADC cytotoxin. Sandramycin is active against Gram-positive bacteria and has potent antitumor activity .
|
-
- HY-A0086R
-
|
Bacterial
Antibiotic
|
Infection
|
Netilmicin (sulfate) (Standard) is the analytical standard of Netilmicin (sulfate). This product is intended for research and analytical applications. Netilmicin (sulfate) (SCH-20569 (sulfate)) is an active aminoglycoside antibiotic against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin.
|
-
- HY-N15063
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
10-Hydroxyundeca-2,4,6, 8-tetraynamide is a polyacetylene antibiotic. 10-Hydroxyundeca-2,4,6,8-tetraynamide has anti-Gram-positive bacteria, negative bacteria, yeast, fungus activity and cytotoxicity .
|
-
- HY-B1210
-
|
Bacterial
Antibiotic
|
Infection
|
Pipemidic acid , a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid inhibits DNA gyrase. Pipemidic acid is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid can be used for the research of intestinal, urinary, and biliary tract infections .
|
-
- HY-B1459AS
-
|
Bacterial
Antibiotic
|
Infection
|
Dicloxacillin- 13C4 is the 13C labeled Dicloxacillin[1]. Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus[2].
|
-
- HY-N13891
-
|
Antibiotic
Bacterial
Apoptosis
|
Infection
Cancer
|
Arisostatin A, a microbial secondary metabolite, is an antibiotic against Gram-positive bacteria and shown to possess potent anti-tumor properties. Arisostatin A induces apoptosis through the activation of caspase-3 and reactive oxygen species (ROS) generation in AMC-HN-4 cells .
|
-
- HY-W587753
-
|
Antibiotic
Bacterial
|
Infection
|
Bacitracin A is an antibiotic, which exhibits antibacterial activity against gram-positive bacteria. Bacitracin A forms complex with long-chain polyisoprenyl pyrophosphates in presence of metal ions, dephosphorylates the lipid carrier intermediate Css-bactoprenyl pyrophosphate, inhibits thus the bacterial cell wall biosynthesis .
|
-
- HY-B1252AS
-
|
Isotope-Labeled Compounds
|
Infection
|
Cefalonium-d4 (hydrate) is the deuterium labeled Cefalonium (hydrate)(HY-B1252A).Cefalonium hydrate is the first-generation β-lactam cephalosporin antibiotic that is widely used to research bovine mastitis caused by Gram-positive bacteria including staphylococci .
|
-
- HY-W748000
-
PM181104; Baringolin
|
Antibiotic
Bacterial
|
Infection
|
Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against Gram-positive bacteria, but no activity against fungi and Gram-negative bacteria .
|
-
- HY-N14172
-
|
Bacterial
Fungal
|
Infection
|
Epicorazine B has activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococcus (VRE), MICs of 12.5-25 μg/mL. Epicorazine B also has effect on Candida albicans with a MIC of 25 μg/mL .
|
-
- HY-100528R
-
Nanchangmycin A (Standard)
|
Bacterial
Antibiotic
Flavivirus
|
Infection
|
Nanchangmycin (Standard) is the analytical standard of Nanchangmycin. This product is intended for research and analytical applications. Nanchangmycin, a polyether antibiotic produced by Streptomyces nanchangensis NS3226, inhibits gram-positive bacteria[1]. Nanchangmycin is a broad spectrum antiviral active against Zika virus[2].
|
-
- HY-106338
-
|
Bacterial
ADC Cytotoxin
Parasite
|
Infection
Cancer
|
Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth of Gram-positive bacteria, and its MIC values is less than 0.2 µg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities .
|
-
- HY-126695
-
|
Antibiotic
|
Infection
|
Altromycin B is a member of the pluramycin antibiotic family isolated from South African bush soil. Altromycin B shows selective antibacterial activity against Gram-positive bacteria and has in vivo activity against P388 leukemia, colon cancer, lung cancer, and ovarian cancer.
|
-
- HY-162171
-
|
Bacterial
|
Infection
|
Antibacterial agent 179 (Compound 23) is a potent antibacterial agent, which effectively kills both Gram-negative and Gram-positive bacteria. Antibacterial agent 179 shows potent in vivo antibacterial efficacy in murine corneal infection models caused by Staphylococcus aureus or Pseudomonas aeruginosa .
|
-
- HY-123325
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Kapurimycin A1 is an anbitiotic that can be isolated from Streptomyces. Kapurimycin A1 has a significant inhibitory effect on Gram-positive bacteria, exhibits cytotoxicity to cultured mammalian cells, and shows strong antitumor activity against the mouse leukemia P388 cell line .
|
-
- HY-N14776
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
11-Demethyltomaymycin is an antibiotic. 11-Demethyltomaymycin has antiviral activity against Escherichia coli T1 and T3 phages and antibacterial activity against Gram-positive bacteria. In addition, 11-Demethyltomaymycin is cytotoxic to leukemia L1210 cells .
|
-
- HY-N14029
-
|
Bacterial
|
Infection
Cancer
|
Coriolin B has anti-Gram-positive bacteria, negative bacteria (weak), yeast and vaginal trichomoniasis activities. Coriolin B of 5 μg/mL can inhibit the growth of yoshida sarcoma 61.6%. Coriolin B has no inhibitory effect on Ehrlich ascites carcinoma in animals .
|
-
- HY-N14030
-
|
Bacterial
|
Infection
Cancer
|
Coriolin C has anti-Gram-positive bacteria, negative bacteria (weak), yeast and vaginal trichomoniasis activities. Coriolin C of 5 μg/mL can inhibit the growth of yoshida sarcoma 61.6%. Coriolin C has no inhibitory effect on Ehrlich ascites carcinoma in animals .
|
-
- HY-N15337
-
OS-4742 A1
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Vineomycin A1 (OS-4742 A1) is an antibiotic against Gram-positive bacteria, which is found in Streptomyces matensis subsp. vineus. Vineomycin A1 also shows antitumor activity in mice. Vineomycin A1 is promising for research of skin fibrosis .
|
-
- HY-125721
-
|
Fungal
Bacterial
Antibiotic
|
Infection
|
Tetranactin is an orally active antibiotic that has insecticidal properties and can inhibit the growth of Gram-positive bacteria and plant pathogenic fungal in vitro. Tetranactin LD50 for intraperitoneal injection in mice is greater than 300 mg/kg, and the LD50 is greater than 15,000 mg/kg .
|
-
- HY-B1002
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
|
Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice .
|
-
- HY-N1672
-
|
Others
|
Infection
|
5,7,2 ',6 '-Tetrahydroxyflavanone is an extract isolated from Scutellaria baicalensis. 5,7,2 ',6 '-Tetrahydroxyflavanone has significant antibacterial activity against gram-positive bacteria. 5,7,2 ',6 '-Tetrahydroxyflavanone can be used to study the treatment of inflammatory diseases .
|
-
- HY-162782A
-
|
Antibiotic
Bacterial
|
Infection
|
V–C6–Bg-PhCl TFA (compound 5e) is a biguanide-vancomycin conjugate. V–C6–Bg-PhCl TFA has broad-spectrum antibacterial activity against both Gram-negative and Gram-positive bacteria .
|
-
- HY-N14689
-
|
Src
|
Infection
Cancer
|
Hibarimicin D is a tyrosine kinase inhibitor. Hibarimicin D selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin D also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL .
|
-
- HY-15597
-
Procoxacin
|
Bacterial
Wnt
β-catenin
Mitophagy
Autophagy
Apoptosis
Antibiotic
Parasite
|
Cancer
|
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells .
|
-
- HY-N14685
-
|
Antibiotic
Fungal
|
Infection
|
Heptaibin is a peptaibol antifungal antibiotic. Heptaibin has the activity against Gram-positive bacteria (MIC is 8 μg/mL) such as Staphylococcus aureus and fungi (MIC is 13-32 μg/mL) such as Aspergillus, Candida albicans and cryptococcus neofordii, and it has moderate anti-Rhabditella pseudoelongata activity (MIC is 50 μg/mL) .
|
-
- HY-12480
-
GSK 1322322
|
Bacterial
|
Infection
|
Lanopepden (GSK 1322322) is a peptidyl peptidase (PDF) inhibitor. Lanopepden inhibits PDF activity, preventing bacterial protein synthesis, thereby exerting antibacterial activity. Lanopepden is primarily effective against Gram-positive bacteria. Lanopepden is used in the study of acute bacterial skin and skin structure infections .
|
-
- HY-N14959
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Deacetylravidomycin N-oxide is an antibiotic that can be produced by Streptomyces ravidus S50905. Deacetylravidomycin N-oxide is active against Gram-positive bacteria but inactive against Gram-negative bacteria. Deacetylravidomycin N-oxide has antitumor activity against P388 leukemia and methamphetamine A fibrosarcoma .
|
-
- HY-P10695
-
|
Bacterial
Antibiotic
|
Infection
|
Bac8c is an antimicrobial peptide with strong antibacterial activity against Gram-negative and Gram-positive bacteria. The MIC of Bac8c against S. aureus, MRSA, S. epidermidis, E. coli, and P. aeruginosa are 2, 8, 4, 4, and 4 μg/mL, respectively .
|
-
- HY-116598
-
GSK 1322322 mesylate
|
Bacterial
|
Infection
|
Lanopepden mesylate (GSK 1322322 mesylate) is a peptide deformase (PDF) inhibitor. Lanopepden mesylate has antibacterial activity by inhibiting the activity of PDF, preventing the correct synthesis of bacterial proteins. Lanopepden mesylate mainly targets Gram-positive bacteria. Lanopepden mesylate can be used in the study of acute bacterial skin and skin structural infections .
|
-
- HY-B0643R
-
|
Bacterial
Antibiotic
|
Infection
|
Dirithromycin (Standard) is the analytical standard of Dirithromycin. This product is intended for research and analytical applications. Dirithromycin (LY237216), a derivative of Erythromycin, is a potent and orally active semi-synthetic macrolide antibiotic. Dirithromycin is active against gram-positive bacteria, Legionella spp., Helicobacter pylori, and Chlamydia trachomatis .
|
-
- HY-122523
-
|
Bacterial
|
Infection
|
Tetromycin A is a tetronic acid-based antibiotic. It reportedly has pronounced activity against Gram-positive bacteria, including methicillin-resistant S. aureus. Related tetromycin derivatives have been found to have anti-trypanosomal activity and inhibit the cysteine protease cathepsin L with Ki values in the low micromolar range.
|
-
- HY-151402
-
|
Bacterial
|
Infection
|
Antimicrobial agent-8 (Compound 15) is a potent antimicrobial agent, and shows potent antimicrobial activity with an MIC range of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-8 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation.
|
-
- HY-129252
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Prothracarcin is an antibiotic with antitumor activity that exerts its tumor cell toxicity by covalently binding to the C-2 amino group of guanine residues in the minor groove of DNA. Prothracarcin also shows antibacterial activity against Gram-positive bacteria and some Gram-negative bacteria such as Escherichia coli .
|
-
- HY-D0008R
-
|
Bacterial
Fungal
Parasite
|
Infection
|
Brilliant green (Standard) is the analytical standard of Brilliant green. This product is intended for research and analytical applications. Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal parasites and fungus. Brilliant green is effective against Gram-positive bacteria .
|
-
- HY-N1416
-
|
Bacterial
Apoptosis
Autophagy
|
Infection
Inflammation/Immunology
Cancer
|
Pogostone is isolated from patchouli oil with anti-bacterial and anti-cancer activities. Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 µg/ml . Pogostone induces cell apoptosis and autophagy .
|
-
- HY-N12178
-
A 83094A; Omomycin
|
Antibiotic
Bacterial
Parasite
|
Infection
|
16-Deethylindanomycin (A 83094A) is an antibiotic, which can be produced by Streptomyces setonii. 16-Deethylindanomycin exhibits antimicrobial activities against gram-positive bacteria Staphylococcus spp. and Streptococcus with MIC of 2-4 µg/mL. 16-Deethylindanomycin exhibits anticoccidial activity against Eimeria tenella .
|
-
- HY-N14887
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Phleomycin E is a heteropeptide antibiotic. Phleomycin E has anti-Gram-positive bacteria, negative bacteria and mycobacterium effects. Phleomycin E extends the survival time of mice transplanted with Ehrman's ascites cancer. Phleomycin E inhibits airy entity carcinoma in mice with an IC50 of 0.31 μg/mL .
|
-
- HY-151401
-
|
Bacterial
|
Infection
|
Antimicrobial agent-7 (Compound 12) is a potent antimicrobial agent, and shows potent antimicrobial activity with an MIC range of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-7 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation .
|
-
- HY-B0275
-
|
Bacterial
HSV
Endogenous Metabolite
Antibiotic
|
Infection
|
Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .
|
-
- HY-B0136
-
FK-482; CI-983
|
Bacterial
Antibiotic
|
Infection
|
Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for infections caused by several Gram-negative and Gram-positive bacteria. Cefdinir can be used for the research of common bacterial infections of the ear, sinus, throat, and skin .
|
-
- HY-N7188
-
|
Bacterial
|
Infection
|
CJ-21,058 is a potent SecA inhibitor with an IC50 value of 15 µg/mL. CJ-21,058 inhibits ATP-dependent translocation of precursor proteins across a bacterial cell membrane. CJ-21,058 shows antibacterial activity against Gram-positive bacteria .
|
-
- HY-B1117R
-
MK-306 (Standard)
|
Bacterial
Antibiotic
Beta-lactamase
|
Infection
|
Cefoxitin sodium (Standard) is the analytical standard of Cefoxitin sodium. This product is intended for research and analytical applications. Cefoxitin sodium is a cephalosporin-class antibiotic. Cefoxitin sodium is highly stable against β-Lactamase (HY-P2998). Cefoxitin sodium has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria.
|
-
- HY-19915B
-
MRX-4 sodium
|
Bacterial
Antibiotic
Monoamine Oxidase
|
Infection
Inflammation/Immunology
|
Contezolid acefosamil sodium (MRX-4), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. Contezolid acefosamil sodium (MRX-4) markedly reduces potential for myelosuppression and monoamine oxidase inhibition (MAOI) .
|
-
- HY-N11137
-
|
Bacterial
|
Infection
|
3′-Omethyl-5′-hydroxydiplacone (compound 2), an C-6-geranylflavonoid, can be isolated from the ethanol extract of Paulownia tomentosa fruits. 3′-Omethyl-5′-hydroxydiplacone has antibacterial activity against Gram-positive bacteria .
|
-
- HY-B0275A
-
|
Bacterial
HSV
Antibiotic
Endogenous Metabolite
|
Infection
|
Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .
|
-
- HY-N6708
-
|
Antibiotic
Bacterial
|
Infection
|
Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .
|
-
- HY-W013766
-
|
Bacterial
Antibiotic
|
Infection
|
Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections .
|
-
- HY-N1671
-
|
Others
|
Infection
|
2',5,6',7-Tetraacetoxyflavanone is an extract isolated from Scutellaria baicalensis. 2',5,6',7-Tetraacetoxyflavanone shows significant antibacterial activity against gram-positive bacteria. 2',5,6',7-Tetraacetoxyflavanone can be used to study the treatment of inflammatory diseases .
|
-
- HY-19892
-
PMX 30063
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Brilacidin (PMX 30063) is an anti-infective antimicrobial with MIC90s of 1 and 8 μg/mL for Gram-positive bacteria Streptococcus pneumonia and Streptococcus viridans, and MIC90 of 8 and 4 μg/mL for Gram-negative bacteria Haemophilus influenza and Pseudomonas aeruginosa. Brilacidin is a defensin mimetic antibiotic compound .
|
-
- HY-N12496
-
|
Fungal
Bacterial
|
Infection
|
Di-O-methylhonokiol is a natural phenolic compound that can be isolated from magnolia flowers. Di-O-methylhonokiol has significant antibacterial activity against Gram-positive bacteria, acid-fast bacilli, and yeast-like and filamentous fungi. Di-O-methylhonokiol can be used in the study of fungal infections .
|
-
- HY-105846
-
|
DNA/RNA Synthesis
Bacterial
Antibiotic
|
Cancer
|
Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer .
|
-
- HY-159688
-
|
Bacterial
|
Infection
|
Cefditoren is an orally active antibiotic with broad-spectrum antibacterial activity, capable of inhibiting both Gram-negative and Gram-positive bacteria. It has a MIC50 of 0.25-0.5 mg/L against Streptococcus pneumoniae strains. Cefditoren is effective against respiratory tract infections and skin infections .
|
-
- HY-Y0264S
-
|
Isotope-Labeled Compounds
|
Infection
|
4-Hydroxybenzoic acid- 13C6 is the 13C labeled isotope of 4-Hydroxybenzoic acid- 13C6.4-Hydroxybenzoic acid is a phenolic derivative of benzoic acid, which can inhibit most Gram-positive bacteria and some Gram-negative bacteria with an IC50 value of 160 μg/mL.
|
-
- HY-168466
-
|
Bacterial
|
Infection
Neurological Disease
Inflammation/Immunology
|
Anti-neuroinflammation agent 2 (compound 4) demonstrates anti-neuroinflammatory and antibacterial activities, with IC50 values of 3.06 µM for TNF-α and 4.31 µM for IL-6, alongside EC50 values ranging from 0.87 to 3.16 µM against Gram-positive bacteria .
|
-
- HY-B1825R
-
|
Antibiotic
Bacterial
Beta-lactamase
|
Infection
|
Cefoxitin (Standard) is the analytical standard of Cefoxitin. This product is intended for research and analytical applications. Cefoxitin is a cephalosporin-class antibiotic. Cefoxitin is highly stable against β-Lactamase (HY-P2998). Cefoxitin has a broad spectrum of antibacterial activity, including Gram-negative and Gram-positive bacteria .
|
-
- HY-14849
-
Razupenem; SM 216601; SMP 601
|
Antibiotic
Bacterial
|
Others
|
PTZ601 (SMP 601) is an antibiotic, which inhibits the gram-positive bacteria, including the Vancomycin (HY-B0671)-resistant Enterococcus faecium (VREF) and Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). PTZ601 exhibits antimicrobial activity in infected mouse models .
|
-
- HY-N14530
-
|
Bacterial
|
Infection
Cancer
|
Cremeomycin has anti-Gram-positive bacteria activity including methicillin-resistant Staphylococcus aureus (MRSA), MIC is 0.2-0.39 μg/mL. Cremeomycin shows cytotoxicity to mouse tumor cell lines P388, L1210, IMC, S180, B16 and SS3 in vitro .
|
-
- HY-N15391
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
1-hydroxynon-2-yn-4-one is an antibiotic. 1-Hydroxy-2-nonyn-4-one has anti-yeast, filamentous fungus, tumor and weak anti-Gram-positive bacteria and Gram-negative bacteria activity .
|
-
- HY-N14144
-
|
Bacterial
|
Infection
Cancer
|
Cremimycin has anti-Gram-positive bacteria activity including methicillin-resistant Staphylococcus aureus (MRSA), MIC is 0.2-0.39 μg/mL. Cremimycin shows cytotoxicity to mouse tumor cell lines P388, L1210, IMC, S180, B16 and SS3 in vitro .
|
-
- HY-124082
-
Lauryl gallate
|
Flavivirus
Bacterial
|
Infection
|
Dodecyl gallate (Lauryl gallate) has been widely used as an antioxidant in food manufacturing, as well as in the pharmaceutical and cosmetic industries. Dodecyl gallate also acts antibacterial activity specifically against Gram-positive bacteria. Dodecyl gallate also is active against a highly relevant animal virus such as African swine fever virus (ASFV) .
|
-
- HY-111333
-
Dioxapyrrolomycin; LL-F42248α; AL-R2081
|
Bacterial
|
Infection
|
Pyrroxamycin is a novel antibiotic produced by Streptomyces, whose chemical structure was determined by chemical properties and X-ray crystallography and 13C NMR spectroscopy analysis. It is active against Gram-positive bacteria and dermatophytes. In this paper, the authors discuss the taxonomy, fermentation, isolation, physicochemical properties, chemical structure, and biological activity of the strain producing Pyrroxamycin.
|
-
- HY-B1466R
-
BAY-f 1353 sodium (Standard)
|
Bacterial
Antibiotic
|
Infection
|
Mezlocillin (sodium) (Standard) is the analytical standard of Mezlocillin (sodium). This product is intended for research and analytical applications. Mezlocillin (BAY-f 1353) sodium is a β-lactam antibiotic, a semisynthetic and extended-spectrum antibiotic. Mezlocillin sodium is active against both gram-negative and gram-positive bacteria. Mezlocillin sodium can be used in bacterial infection research[1][2].
|
-
- HY-W011117
-
|
Bacterial
DNA/RNA Synthesis
Antibiotic
|
Infection
|
Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase. Danofloxacinh has the potential for respiratory diseases in cattle, swine, and chickens treatment .
|
-
- HY-B0275C
-
|
Bacterial
HSV
Antibiotic
Endogenous Metabolite
|
Infection
|
Oxytetracycline calcium is an antibiotic belonging to the tetracycline class. Oxytetracycline calcium potently inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline calcium is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline calcium also possesses anti-HSV-1 activity .
|
-
- HY-145854
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
GA-O-06, a 18β-Glycyrrhetinic acid derivative, is a potent antimicrobial and anti-inflammatory agent. GA-O-06 exerts anti-inflammation through the inhibition of NO, pro-inflammatory cytokines and chemokines. GA-O-06 displays a high antimicrobial activity against Gram-positive bacteria .
|
-
- HY-A0097
-
Antibiotic MDL-507; MDL-507
|
Bacterial
Antibiotic
|
Infection
|
Teicoplanin is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .
|
-
- HY-P5563
-
|
Bacterial
|
Infection
|
PP113 is an antimicrobial peptide is active against Gram-negative and Gram-positive bacteria, E.coli (MIC: 73.3 uM), B. subtilis (MIC: 23.3 uM), S. aureus (MIC: 13 uM), S. lutea (MIC: 16.7 uM), and B. pumilu (MIC: 23.3 uM) .
|
-
- HY-119789
-
|
Antibiotic
Bacterial
|
Infection
|
Albofungin (Antibiotic P-42-1) is isolated from the culture filtrate of Actinomyces tumemacerans strain INMI.P-42. Albofungin shows highly active on a wide variety of gram-positive bacteria and fungi. Albofungin shows cytotoxic to HeLa cell cultures and exhibited antitumor activity on EHRLICH ascites tumor in mice.
|
-
- HY-B0977R
-
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Dicloxacillin (Sodium hydrate) (Standard) is the analytical standard of Dicloxacillin (Sodium hydrate). This product is intended for research and analytical applications. Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus .
|
-
- HY-A0097A
-
Antibiotic MDL-507 sodium; MDL-507 sodium
|
Antibiotic
HIV
SARS-CoV
|
Infection
|
Teicoplanin sodium is a glycopeptide antibiotic indicated for use in serious infections caused by Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus and Enterococcus aureus.Teicoplanin sodium shows antiviral activity for HIV-1, SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity .
|
-
- HY-126858
-
(+)-Ambuic acid
|
ERK
JNK
NO Synthase
COX
|
Infection
Inflammation/Immunology
|
Ambuic acid exhibits antimicrobial activity against Staphylococcus aureus, with IC50 of 43.9 μM for strain ATCC 6538. Ambuic acid is an inhbitor for the biosynthesis of cyclic peptide quorum sensing molecules (quormones) in gram-positive bacteria. Ambuic acid exhibits anti-inflammatory activity through ERK/JNK/MAPK signaling pathway .
|
-
- HY-161263
-
|
Bacterial
|
Infection
|
Antibacterial agent 182 (compound 8c) is an antibacterial agent that shows antibacterial activity against various Gram-positive bacteria, particularly against Vancomycin-resistant Enterococcus faecalis (MIC ≤0.125 μg/mL). Antibacterial agent 182 inhibits biofilm formation of Staphylococcus aureus and Pseudomonas aeruginosa at sub-MIC doses .
|
-
- HY-155682
-
|
Bacterial
|
Infection
|
Antibacterial agent 150 (compound 5g) is an antibacterial agent with potent antibacterial activity against both Gram-positive bacteria and Gram-negative bacteria (MIC values ranging from 1-32 μg/mL). Antibacterial agent 150 can increase survival rate of MRSA (Methicillin-resistant Staphylococcus aureus)-infected mice .
|
-
- HY-N10755A
-
|
Cytochrome P450
Bacterial
|
Infection
|
(±)-ε-Viniferin is a racemate of ε-Viniferin (HY-N3841). (±)-ε-Viniferin exhibits P450 inhibitory antioxidants, as well as hepato-protective and antimicrobial activities. (±)-ε-Viniferin has antibacterial and antibiofilm activity against Gram-positive bacteria Streptococcus pneumoniae with a MIC of 20 μM .
|
-
- HY-N12096
-
α-Acetylsalazinic acid
|
Bacterial
|
Infection
|
Galbinic acid (α-Acetylsalazinic acid), a lichen acid, shows antibacterial activities against the Gram-positive bacteria B. cereus, B. subtilis, and S. aureus (MICs=62.5, 62.5, 250 μg/ml, respectively). Galbinic acid inhibits the Gram-negative bacterium E. coli (MIC=125 μg/ml) .
|
-
- HY-122076
-
|
Antibiotic
Bacterial
Fungal
|
Infection
|
A-26771B is an antibiotic can be obtained from Penicillium turbatum. A-26771B exhibits moderate antimicrobial activity against Gram-positive bacteria, mycoplasma, and fungi. A-26771B also inhibits potassium-dependent ATPase in rat liver mitochondria .
|
-
- HY-145853
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
GA-O-02, a 18β-Glycyrrhetinic acid derivative, is a potent antimicrobial and anti-inflammatory agent. GA-O-02 exerts anti-inflammation through the inhibition of NO, pro-inflammatory cytokines and chemokines. GA-O-02 displays a high antimicrobial activity against Gram-positive bacteria .
|
-
- HY-W011117S
-
|
Isotope-Labeled Compounds
Bacterial
DNA/RNA Synthesis
|
Infection
|
Danofloxacin-d3 is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase[1][2].
|
-
- HY-B0275B
-
|
Bacterial
HSV
Antibiotic
Endogenous Metabolite
|
Infection
|
Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity .
|
-
- HY-19892A
-
PMX 30063 tetrahydrochloride
|
Bacterial
Antibiotic
|
Infection
Cancer
|
Brilacidin tetrahydrochloride (PMX 30063 tetrahydrochloride) is an anti-infective antimicrobial with MIC90s of 1 and 8 μg/mL for Gram-positive bacteria Streptococcus pneumonia and Streptococcus viridans, and MIC90 of 8 and 4 μg/mL for Gram-negative bacteria Haemophilus influenza and Pseudomonas aeruginosa. Brilacidin tetrahydrochloride is a defensin mimetic antibiotic compound .
|
-
- HY-W011117S1
-
|
Isotope-Labeled Compounds
|
Others
|
Danofloxacin-d3-1 is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase .
|
-
- HY-125365
-
|
Bacterial
Reactive Oxygen Species
Antibiotic
|
Infection
|
Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy .
|
-
- HY-170760
-
|
Bacterial
|
Infection
|
Antibacterial agent 258 (Compound 11e) is an antibacterial agent, that destory the bacteria cell membrane, and inhibits various gram-positive bacteria (MIC for Staphylococcus aureus is 1-2 μg/mL). Antibacterial agent 258 exhibits low hemolytic activity and low cytotoxicity. Antibacterial agent 258 exhibits anti-infectious efficacy in mouse models .
|
-
- HY-105321R
-
PBT 2 (Standard)
|
Bacterial
|
Neurological Disease
|
PBT 1033 (Standard) is the analytical standard of PBT 1033. This product is intended for research and analytical applications. PBT 1033 (PBT 2) is an orally active copper/zinc ionophore. PBT 1033 restores cognition in mouse models of Alzheimer's disease (AD). PB 1033 also has antibacterial activity against Gram-positive bacteria[1][2].
|
-
- HY-113829
-
|
Antibiotic
Bacterial
|
Infection
Inflammation/Immunology
|
Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs . Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury .
|
-
- HY-B0519A
-
Tylosin
1 Publications Verification
|
Bacterial
Antibiotic
|
Infection
|
Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-P5560
-
|
Bacterial
|
Infection
|
PP13 is an antimicrobial peptide, and is active against Gram-negative and Gram-positive bacteria E.coli (MIC: 16.7 uM), B. subtilis (MIC: 13.3 uM), S. aureus (MIC: 23.3 uM), S. lutea (MIC: 8.0 uM), and B. pumilu (MIC: 9.0 uM) .
|
-
- HY-P10539
-
|
Bacterial
|
Infection
|
Hp1404 is a novel cationic antimicrobial peptide. Hp1404 has specific inhibitory activity against Gram-positive bacteria, including Staphylococcus aureus (MRSA) resistant to Laburnetin (HY-N7382). Hp1404 has antimicrobial activity, low toxicity, and is not prone to drug resistance, and can be used in the research of antimicrobial agents .
|
-
- HY-17586AS
-
MDL-63397-d6; BI-397-d6
|
Bacterial
Antibiotic
|
Infection
|
Dalbavancin-d6 is the deuterium labeled Dalbavancin[1]. Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[2][3].
|
-
- HY-117840
-
|
Antibiotic
Bacterial
|
Infection
|
Altromycin F is an anthraquinone-derived antibiotic produced by the actinomycete AB 1246E-26 isolated from a South African bush soil. Altromycin F has antibacterial activity against Gram-positive bacteria, particularly Streptococcus and Staphylococcus, with a microbial inhibitory concentration (MIC) ranging from 0.2-3.12 μg/mL .
|
-
- HY-B0359R
-
|
Fungal
Antibiotic
|
Infection
|
Fenticonazole (Nitrate) (Standard) is the analytical standard of Fenticonazole (Nitrate). This product is intended for research and analytical applications. Fenticonazole Nitrate is an antifungal imidazole ring derivative. Fenticonazole Nitrate operates via hindering ergosterol integration, and sequentially destructing the cytoplasmatic outer membrane. Fenticonazole Nitrate is effective against Gram-positive bacteria, mycoses, and vaginal candidiasis .
|
-
- HY-N14415
-
|
Bacterial
|
Infection
Cancer
|
Cochleamycin A showed strong inhibitory activity against tumor cells, with IC50s (μg/mL) of P388, HL60, K562, COL0205 and HT29 cells of 1.6, 14.0, 6.2, 16.5 and 19.1, respectively. Cochleamycin A also has anti-Gram-positive bacteria activity .
|
-
- HY-N14548
-
|
Antibiotic
Bacterial
|
Infection
|
Cryptosporiopsin can be isolated from the strain of Cryptosporiopsis sp. and Sporormia affinis. Cryptosporiopsin has antibacterial activity to many kinds of basidiomycetes, algal fungi, ascomycetes and hemiplegia fungi that cause wood rot, and can inhibit spore germination of Phytophthora potatoes. Cryptosporiopsin also has certain activity against gram-positive bacteria and negative bacteria .
|
-
- HY-B1729R
-
|
Oxidative Phosphorylation
Bacterial
Fungal
|
Infection
|
Phenoxyethanol (Standard) is the analytical standard of Phenoxyethanol. This product is intended for research and analytical applications. Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .
|
-
- HY-B1729S1
-
|
Isotope-Labeled Compounds
Oxidative Phosphorylation
Bacterial
Fungal
|
Infection
|
Phenoxyethanol-d4 is the deuterium labeled Phenoxyethanol[1]. Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al[2].
|
-
- HY-N14111
-
|
Bacterial
Fungal
|
Infection
|
Cuevaene A can be isolated from the strain of gdmAI-disrupted Streptomyces sp. LZ35 and. Cuevaene A displays moderate activity against Gram-positive bacteria (e.g., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4) .
|
-
- HY-P1748
-
EC 3.4.24.27; TML
|
Endogenous Metabolite
|
Infection
|
Thermolysin, Bacillus thermoproteolyticus rokko (EC 3.4.24.27) (TML) is a thermostable neutral metalloproteinase enzyme secreted by the Gram-positive bacteria Bacillus thermoproteolyticus. Thermolysin catalyzes the hydrolysis of peptide bonds containing hydrophobic residues .
Optimal pH: 8.0. Considerably stable from pH 5 to 9.5.
Optimal temperature : 70 °C
|
-
- HY-N8316
-
|
Others
|
Infection
|
Rugulotrosin A is an antibiotic originally isolated from Penicillium. It is active against the Gram-positive bacteria E. faecalis, B. cereus, B. subtilis, and S. aureus with 99% lethal dose (LD99) values of 1.6, 3.1, 5.5, and 200 μg/mL, respectively.1 Rugulotrosin A is inactive against Gram-negative bacteria.
|
-
- HY-B0519B
-
|
Bacterial
Antibiotic
|
Infection
|
Tylosin phosphate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin phosphate is widely used as a feed additive for promoting animal growth. Tylosin phosphate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-B1729S
-
|
Isotope-Labeled Compounds
Oxidative Phosphorylation
Bacterial
Fungal
|
Infection
|
Phenoxyethanol-d2 is the deuterium labeled Phenoxyethanol[1]. Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al[2].
|
-
- HY-151399
-
|
Bacterial
|
Infection
|
Antimicrobial agent-5 is an potent antimicrobial agent, and displays excellent cell selectivity against Gram-negative bacteria and Gram-positive bacteria. Antimicrobial agent-5 blocks the interaction between LPS and CD14/TLR4 receptor, and shows anti-inflammatory activity against LPS-induced inflammation .
|
-
- HY-10394R
-
PNU-100766 (Standard)
|
Bacterial
Antibiotic
|
Infection
|
Linezolid (Standard) is the analytical standard of Linezolid. This product is intended for research and analytical applications. Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics .
|
-
- HY-B1002S
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
|
Oxolinic acid-d5 is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].
|
-
- HY-B1002R
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
|
Infection
|
Oxolinic acid (Standard) is the analytical standard of Oxolinic acid. This product is intended for research and analytical applications. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice .
|
-
- HY-B0519
-
|
Bacterial
Antibiotic
|
Infection
|
Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-123121
-
|
Antibiotic
Apoptosis
Bacterial
NF-κB
|
Infection
Inflammation/Immunology
Cancer
|
Nargenicin A1 is an antibiotic agent against various Gram-positive bacteria. Nargenicin A1 shows anti-inflammatory activity. Nargenicin A1 protects HINAE cells against Tacrolimus (HY-13756)-induced DNA damage and apoptosis. Nargenicin A1 can also be used for the research of acute myeloid leukemia .
|
-
- HY-13212
-
cis-2-Decenoic acid
|
Bacterial
|
Cancer
|
(Z)-2-decenoic acid (cis-2-Decenoic acid) is an unsaturated fatty acid produced by Pseudomonas aeruginosa. (Z)-2-decenoic acid induces a dispersion response in biofilms formed by a range of gram-negative bacteria, including P. aeruginosa, and by gram-positive bacteria. (Z)-2-decenoic acid inhibits biofilm development .
|
-
- HY-N14112
-
|
Bacterial
Fungal
|
Infection
|
Cuevaene B can be isolated from the strain of gdmAI-disrupted Streptomyces sp. LZ35 and. Cuevaene B displays moderate activity against Gram-positive bacteria (e.g., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4) .
|
-
- HY-16770
-
P-005672
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne .
|
-
- HY-B0275S
-
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
Endogenous Metabolite
HSV
|
Infection
|
Oxytetracycline-d6 is deuterium labeled Oxytetracycline. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .
|
-
- HY-125650
-
PUM
|
Antibiotic
DNA/RNA Synthesis
Bacterial
Nucleoside Antimetabolite/Analog
|
Infection
|
Pseudouridimycin (PUM) is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis .
|
-
- HY-B0220H
-
|
DNA/RNA Synthesis
Bacterial
Antibiotic
|
Infection
|
Erythromycin hydrochloride is a protein synthesis inhibitor with activity against the growth of both Gram-negative and Gram-positive bacteria. Erythromycin hydrochloride is commonly used in biomedicine to inhibit diseases caused by bacterial infections. Erythromycin hydrochloride is also involved in the inhibition of mammalian mRNA splicing. The application range of erythromycin hydrochloride includes respiratory tract infections, skin infections, and other infections caused by sensitive bacteria .
|
-
- HY-112959
-
TD-6424
|
Antibiotic
Bacterial
|
Infection
|
Telavancin (TD-6424) is a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). Telavancin disrupts cell membrane integrity, can be used for research of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria .
|
-
- HY-B1210R
-
|
Bacterial
Antibiotic
|
Infection
|
Pipemidic acid (Standard) is the analytical standard of Pipemidic acid. This product is intended for research and analytical applications. Pipemidic acid , a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid inhibits DNA gyrase. Pipemidic acid is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid can be used for the research of intestinal, urinary, and biliary tract infections .
|
-
- HY-B0226A
-
(E)-Nitrofural
|
Bacterial
Parasite
|
Infection
|
(E)-Nitrofurazone ((E)-Nitrofural) is a topical broad-spectrum antibacterial agent effective against both Gram-negative and Gram-positive bacteria. (E)-Nitrofurazone also possesses antiprotozoal and antiparasitic activities. (E)-Nitrofurazone is commonly used in the research of superficial wounds, burns, skin infections, pyoderma, infectious skin diseases, trypanosomiasis, and acute bacillary dysentery .
|
-
- HY-137323
-
|
Antibiotic
Bacterial
|
Infection
|
Leucinostatin H is a polypeptide antibiotic discovered in Paecilomyces marquandii, characterized by a tertiary amine-oxide terminal group. Leucinostatin H exhibits inhibitory activity against Gram-positive bacteria, such as Bacillus subtilis, B. cereus, and Staphylococcus aureus (MIC 10-100 μg/mL). Leucinostatin H holds potential for research in anti-infective and plant disease control applications .
|
-
- HY-13858A
-
P-005672 hydrochloride
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne
.
|
-
- HY-129454
-
Antibiotic TPU-0037-A
|
Antibiotic
|
Infection
|
TPU-0037A is an antibiotic and a congener of lydicamycin. It inhibits the growth of Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), B. subtilis, and M. luteus (MICs=1.56-12.5 μg/mL), but not Gram-negative E. coli, P. mirabilis, P. vulgaris, or P. aeruginosa strains (MICs=>50 μg/mL).
|
-
- HY-118906
-
|
Antibiotic
Bacterial
|
Infection
|
BO-1165 is an antibiotic with good antibacterial activity against Gram-negative bacteria, but almost no activity against Gram-positive bacteria and anaerobic bacteria. BO-1165 has high antibacterial activity against Pseudomonas aeruginosa (MIC50=3.12 mg/L) and P. cepacia (MIC50=1.56 mg/L) .
|
-
- HY-P1629
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .
|
-
- HY-130173
-
|
Bacterial
Fungal
Na+/K+ ATPase
Apoptosis
Antibiotic
|
Infection
Cancer
|
Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H +-ATPases (V-ATPases). Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi . Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) .
|
-
- HY-N7165
-
|
Phosphatase
Bacterial
|
Infection
Metabolic Disease
|
3-O-cis-p-Coumaroyl maslinic acid (compound 16) is a natural compound isolated from the ethyl acetate extract of leaves of Miconia albicans.3-O-cis-p-Coumaroyl maslinic acid can inhibit PTP1B, with the IC50 of 0.46 μM, and shows antimicrobial activity on Gram-positive bacteria and yeasts .
|
-
- HY-168109
-
|
Antibiotic
Bacterial
|
Infection
|
Antibacterial agent 246 (compound A33) is a antibacterial agent and has minimum inhibitory concentrations (MICs) of 0.5-4 μg/mL against twenty-three Gram-positive bacteria. Antibacterial agent 246 in combination with Polymyxin E(HY-113678) E inhibits the growth of various Gram-negative bacteria with the fractional inhibitory concentration index of 0.066 .
|
-
- HY-125042
-
|
Bacterial
|
Infection
|
Sarothralin G is an antibacterial compound isolated from Hypericum japonicum Thunb. (Japanese spurfle). The structure of Sarothralin G contains phenolic and aromatic acid moieties and shows excellent antibacterial activity against Gram-positive bacteria such as Staphylococcus aureus, Bacillus subtilis and Nocardia spp., which is stronger than Sarothralen A, B and Saroaspidin A, B, C. Sarothralin G exhibits significant antibacterial potential.
|
-
- HY-N14344
-
|
Bacterial
|
Infection
|
Manumycin G has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin G inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC50 is 15.6 μg/mL) .
|
-
- HY-164051
-
|
Bacterial
|
Infection
|
1650-M15 is an inhibitor of lipoteichoic acid synthase (LtaS). It has inhibitory activity against Gram-positive bacteria but has no significant inhibitory effect against Gram-negative bacteria. The IC50s of 1650-M15 against MRSA and MSSA are 62.44 μM and 66.42 μM, respectively, and the MICs are both 200 μM .
|
-
- HY-B0275R
-
|
Bacterial
HSV
Endogenous Metabolite
Antibiotic
|
Infection
|
Oxytetracycline (Standard) is the analytical standard of Oxytetracycline. This product is intended for research and analytical applications. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .
|
-
- HY-B0136R
-
|
Bacterial
Antibiotic
|
Infection
|
Cefdinir (Standard) is the analytical standard of Cefdinir. This product is intended for research and analytical applications. Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for infections caused by several Gram-negative and Gram-positive bacteria. Cefdinir can be used for the research of common bacterial infections of the ear, sinus, throat, and skin .
|
-
- HY-10394S1
-
PNU-100766-d8
|
Antibiotic
Bacterial
Isotope-Labeled Compounds
|
Infection
|
PNU-100766-d8 is deuterated labeled Linezolid (HY-10394). Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics .
|
-
- HY-N14342
-
|
Bacterial
|
Infection
|
Manumycin E has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin E inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC50 is 15.6 μg/mL) .
|
-
- HY-105751
-
Kalamycin; U-19718
|
Antibiotic
Bacterial
Beta-lactamase
Fungal
|
Infection
|
Kalafungin is an antibiotic, antimicrobial agent and a β-lactamase inhibitor from marine Streptomyces, with IC50 of 225.37 μM. Kalafungin destroys cell membranes. Kalafungin shows inhibitory activities against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria (such as S. aureus ATCC 33591 and S. aureus ATCC 23591), and, to a lesser extent, gram-negative bacteria .
|
-
- HY-18324
-
REP-3123
|
Antibiotic
|
Inflammation/Immunology
|
CRS3123 is a potent and orally active narrow-spectrum antibiotic. CRS3123 inhibits bacterial methionyl-tRNA synthetase. CRS3123 has potent activity against Clostridium difficile (C. difficile) and aerobic Gram-positive bacteria but little activity against Gram-negative bacteria, including anaerobes. CRS3123 has the potential for the research of C. difficile infections .
|
-
- HY-N14343
-
|
Bacterial
|
Infection
|
Manumycin F has anti-Gram-positive bacteria and Escherichia coli effects, but the effect is very weak against other anti-Gram-negative bacteria, and has no effect on fungi. Manumycin F inhibits RAS Faraday base transfer and has weak cytotoxic activity against human cloned cancer cell lines HCT-116 (IC50 is 15.6 μg/mL) .
|
-
- HY-125650A
-
PUM TFA
|
Antibiotic
DNA/RNA Synthesis
Bacterial
Nucleoside Antimetabolite/Analog
|
Infection
|
Pseudouridimycin (PUM) TFA is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin TFA is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin TFA inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis .
|
-
- HY-B0330D
-
Dextrofloxacin
|
Bacterial
Antibiotic
|
Infection
|
(R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .
|
-
- HY-N1416R
-
|
Bacterial
Apoptosis
Autophagy
|
Infection
Inflammation/Immunology
|
Pogostone (Standard) is the analytical standard of Pogostone. This product is intended for research and analytical applications. Pogostone is isolated from patchouli oil?with anti-bacterial and anti-cancer activities.?Pogostone inhibits both gram negative and gram positive bacteria, also show inhibitory effect on corynebacterium xerosis with a MIC value of 0.098 μg/ml .?Pogostone induces cell apoptosis and autophagy .
|
-
- HY-15597R
-
Procoxacin (Standard)
|
Bacterial
Wnt
β-catenin
Mitophagy
Autophagy
Apoptosis
Antibiotic
Parasite
|
Cancer
|
Salinomycin (Standard) is the analytical standard of Salinomycin. This product is intended for research and analytical applications. Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells[1][2][3].
|
-
- HY-A0279
-
Pristinamycine
|
Bacterial
Antibiotic
|
Infection
|
Pristinamycin, produced by Streptomyces pristinaespiralis, is an orally active streptogramin-like antibiotic consisting of two chemically unrelated components: Pristinamycin I (PI) and Pristinamycin II (PII). Pristinamycin is highly active against many antibiotic-resistant pathogens, particularly Gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA) and Enterococcus faecium (VREF) .
|
-
- HY-B0275AR
-
|
Bacterial
HSV
Antibiotic
Endogenous Metabolite
|
Infection
|
Oxytetracycline (hydrochloride) (Standard) is the analytical standard of Oxytetracycline (hydrochloride). This product is intended for research and analytical applications. Oxytetracycline hydrochloride is an antibiotic belonging to the tetracycline class. Oxytetracycline hydrochloride potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline hydrochloride is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline hydrochloride also possesses anti-HSV-1 activity .
|
-
- HY-23848
-
non-8-ynoic acid
|
Bacterial
|
Infection
|
8-Nonynoic acid (non-8-ynoic acid) is a fatty acid that belongs to the group of octynoic acids. It exhibits antibacterial activity against gram-positive bacteria by binding to bacterial fatty acids. 8-Nonynoicacid also inhibits growth of gram-negative bacteria by inhibiting the synthesis of fatty acids. It is also capable of inhibiting growth of both aerobic and anaerobic bacteria in biochemical assays.
|
-
- HY-117818
-
Antibiotic DC 116
|
Antibiotic
|
Cancer
|
Sapurimycin is an antitumor antibiotic isolated from Streptomyces DO-116 and belongs to the capramycin family. Sapurimycin exhibits potent activity against Gram-positive bacteria and exhibits significant antitumor effects against leukemia P388 and sarcoma 180 in mouse models. In vitro studies have shown that Sapurimycin can induce single-strand breaks in supercoiled plasmid DNA .
|
-
- HY-16485
-
TD-6424 hydrochloride
|
Antibiotic
Bacterial
|
Infection
|
Telavancin hydrochloride is the hydrochloride form of Telavancin (HY-112959). Telavancin hydrochloride is a semisynthetic derivative of vancomycin, and exhibits antibacterial efficacy through inhibition of cell wall synthesis and disruption of cell membrane barrier function. Telavancin hydrochloride is efficient against antibiotic resistant S. aureus strains MRSA, VISA, and hVISA. Telavancin hydrochloride attenuates gram positive bacteria induced complicated skin and skin structure infections (cSSSI) .
|
-
- HY-123347
-
|
Endogenous Metabolite
|
Infection
|
TPU-0037C is a metabolite of the marine actinomycete S. platensis that is structurally similar to Lydicamycin (HY-125414). It is active against Gram-positive bacteria (MICs=0.39-3.13 μg/mL), including methicillin-resistant S. aureus strains (MIC=3.13 μg/mL), but is ineffective against Gram-negative bacteria (MICs=>50 μg/mL).
|
-
- HY-B1916
-
Spiramycin B; Spiramycin II; Foromacidin B
|
Antibiotic
Bacterial
Parasite
|
Infection
|
Acetylspiramycin (Spiramycin B) is an effective oral macrolide antibiotic produced by Streptomyces, It can inhibit the splenic lymphocyte transformation induced by phytohemagglutinin (PHA), LPS (HY-D1056) and antigen, reduce the procoagulant activity of macrophages, have good antibacterial effect on gram-positive bacteria, and is also an effective antigenic insect agent, which can be used to fight parasitic infection .
|
-
- HY-118362
-
|
Bacterial
|
Infection
|
Netzahualcoyonol is a quinone methyl triterpene isolated from the roots of Salacia multiflora (Lam.) DC. Netzahualcoyonol exhibits antibacterial and anti-biofilm activities. Netzahualcoyonol inhibits Gram-positive bacteria (MIC=3.26–52 μM). Additionally, Netzahualcoyonol demonstrates cytotoxicity against Hep G2 cells (IC50 = 1.95 μM) but exhibits low toxicity towards Vero cells .
|
-
- HY-19827
-
(+)-Aeroplysinin-1
|
Bacterial
HIV
Apoptosis
|
Infection
Cancer
|
Aeroplysinin 1 ((+)-Aeroplysinin-1), a secondary metabolite isolated from marine sponges, shows potent antibiotic effects on Gram-positive bacteria and exerts antiviral activity against HIV-1 (IC50=14.6 μM). Aeroplysinin 1 has anti-inflammatory, anti-angiogenic and anti-tumor activities. Aeroplysinin 1 induces apoptosis in endothelial cells .
|
-
- HY-B0885
-
(±)-Econazol
|
Fungal
Bacterial
Calcium Channel
Cytochrome P450
|
Infection
Metabolic Disease
|
Econazole ((±)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage .
|
-
- HY-P0270
-
Magainin II
|
Bacterial
Antibiotic
Fungal
|
Infection
|
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .
|
-
- HY-N14056
-
|
Bacterial
|
Infection
Cancer
|
Chrolactomycin is found in the strain of Streptomyces sp. 569N-3. The IC50 of Chrolactomycin for ACHN, A431, McF-7 and T24 cells are 1.2 μM, 1.6 μM, 0.69 μM and 0.45 μM, respectively. Chrolactomycin has only anti-Gram-positive bacteria activity with the MIC of 5.2-10.4 μg/mL .
|
-
- HY-P10508
-
|
Bacterial
Apoptosis
|
Infection
Cancer
|
Pantinin-1 is an antimicrobial peptide found in the venom of the Pandinus imperator scorpion. Pantinin-1 has potent antimicrobial activity against Gram-positive bacteria and fungi, weak antimicrobial activity against Gram-negative bacteria, and very low hemolytic activity against human erythrocytes. Pantinin-1 also has anticancer activity and can induce apoptosis in tumor cells .
|
-
- HY-P10228
-
|
Fungal
Bacterial
|
Infection
|
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .
|
-
- HY-N14163
-
|
Bacterial
|
Infection
Cancer
|
Diperamycin has activity against Gram-positive bacteria, including Enterococcus seriolicida and MRSA (MICs of 0.10-0.20 μg/mL). Diperamycin also strongly inhibits the activity of L1210, P388, LS-180, KB, HeLaS3, Meth A and B16-BL6 (IC50s of 0.009-0.098 μg/mL) .
|
-
- HY-105463
-
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology .
|
-
- HY-16745A
-
KRP-AM1977 hydrochloride
|
Bacterial
|
Infection
|
Lascufloxacin (KRP-AM1977) hydrochloride is a potent antibacterial compound candidate with broad-spectrum activity against various clinical isolates. Lascufloxacin hydrochloride shows the most potent activity against Gram-positive bacteria compared to other tested quinolones. Lascufloxacin hydrochloride demonstrates incomplete cross-resistance against existing quinolone-resistant strains. Lascufloxacin hydrochloride has potent inhibitory activity against both wild-type and mutated target enzymes.
|
-
- HY-N6687
-
A-23187; Antibiotic A-23187
|
Oxidative Phosphorylation
Bacterial
Fungal
Apoptosis
Autophagy
Antibiotic
|
Infection
Cancer
|
Calcimycin (A-23187) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin induces Ca 2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin induces apoptosis .
|
-
- HY-W013766R
-
|
Bacterial
Antibiotic
|
Infection
|
Pipemidic acid (trihydrate) (Standard) is the analytical standard of Pipemidic acid (trihydrate). This product is intended for research and analytical applications. Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections .
|
-
- HY-149734
-
|
Bacterial
|
Infection
|
MA220607 is an antibacterial agent with low hemolytic toxicity and a dual-target mechanism of action (MOA). MA220607 promotes FtsZ protein polymerization, also increases the permeability of bacterial membranes and inhibits biofilm formation. The resistance rate of MA220607 is low, and the MICs against Gram-positive bacteria and Gram-negative bacteria are Table 0.062-2 μg/mL and 0.5-4 μg/mL, respectively) .
|
-
- HY-W011117R
-
|
Bacterial
DNA/RNA Synthesis
Antibiotic
|
Infection
|
Danofloxacin (Standard) is the analytical standard of Danofloxacin. This product is intended for research and analytical applications. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase. Danofloxacinh has the potential for respiratory diseases in cattle, swine, and chickens treatment .
|
-
- HY-B0519AS
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
Tylosin-d3 is the deuterium labeled Tylosin. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle[1][2][3].
|
-
- HY-132242R
-
|
HDAC
Apoptosis
Drug Metabolite
|
Cancer
|
Pipemidic acid (trihydrate) (Standard) is the analytical standard of Pipemidic acid (trihydrate). This product is intended for research and analytical applications. Pipemidic acid trihydrate, a derivative of Piromidic acid, is an antibacterial agent. Pipemidic acid trihydrate inhibits DNA gyrase. Pipemidic acid trihydrate is active against gram-negative bacteria including Pseudomonas aeruginosa as well as some gram-positive bacteria. Pipemidic acid trihydrate can be used for the research of intestinal, urinary, and biliary tract infections .
|
-
- HY-119894
-
NSC 102809
|
Antibiotic
|
Infection
|
Althiomycin is a polyketide synthase-derived thiazole antibiotic originally isolated from S. althioticus. It is active against Gram-positive bacteria, including S. aureus, S. epidermidis, and S. pyogenes (MICs=25, 25, and 3.1 μg/mL, respectively).2 Althiomycin inhibits protein synthesis in E. coli when used at concentrations of 1 and 10 μg/mL but not in isolated rabbit reticulocytes at 100 μg/mL.
|
-
- HY-B1050
-
SB-265805S; LB-20304a
|
Bacterial
Antibiotic
DNA/RNA Synthesis
Topoisomerase
|
Infection
|
Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections .
|
-
- HY-B0275BR
-
|
Bacterial
HSV
Antibiotic
Endogenous Metabolite
|
Infection
|
Oxytetracycline (dihydrate) (Standard) is the analytical standard of Oxytetracycline (dihydrate). This product is intended for research and analytical applications. Oxytetracycline dihydrate is an antibiotic belonging to the tetracycline class. Oxytetracycline dihydrate potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline dihydrate is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline dihydrate also possesses anti-HSV-1 activity .
|
-
- HY-121348
-
U-47929
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
Ficellomycin is a nitrogen-containing bicyclic antibiotic with strong activity against Gram-positive bacteria, including multidrug-resistant strains of Staphylococcus aureus. Ficellomycin works by inducing the formation of defective 34S DNA fragments, which interfere with the semi-conservative DNA replication process. These fragments lack the ability to integrate into larger DNA segments and eventually form a complete bacterial chromosome. Ficellomycin can be used in research for various bacterial diseases .
|
-
- HY-112661
-
Antibiotic PC-766B
|
Antibiotic
Bacterial
Fungal
|
Infection
Cancer
|
PC-766B is a macrolide antibiotic. PC-766B is active against Gram-positive bacteria, and some fungi and yeasts, but inactive against Gram-negative bacteria. PC-766B shows antitumor activity against murine tumor cells. PC-766B has weak inhibitory activity against Na +, K +-ATPase .
|
-
- HY-B0519AR
-
|
Bacterial
Antibiotic
|
Infection
|
Tylosin (Standard) is the analytical standard of Tylosin. This product is intended for research and analytical applications. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-146811
-
|
Bacterial
|
Inflammation/Immunology
|
HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model .
|
-
- HY-B0519BR
-
|
Bacterial
Antibiotic
|
Infection
|
Tylosin (phosphate) (Standard) is the analytical standard of Tylosin (phosphate). This product is intended for research and analytical applications. Tylosin phosphate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin phosphate is widely used as a feed additive for promoting animal growth. Tylosin phosphate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-125365R
-
|
Bacterial
Reactive Oxygen Species
Antibiotic
|
Infection
|
Rifamycin S (Standard) is the analytical standard of Rifamycin S. This product is intended for research and analytical applications. Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy .
|
-
- HY-P10515
-
|
Bacterial
Fungal
|
Infection
Cancer
|
AcrAP2 is an antimicrobial peptide present in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP2 is inhibitory against Gram-positive bacteria and yeast but is essentially inactive against Gram-negative bacteria. A cation-enhanced AcrAP2 analog (AcrAP2a) exhibits significant antiproliferative effects at low concentrations against certain human cancer cell lines. AcrAP2 can be used in antibacterial and anti-tumor research .
|
-
- HY-N6680
-
|
Bacterial
Antibiotic
|
Infection
|
Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections [1][2].
|
-
- HY-147546
-
|
Bacterial
|
Infection
|
Antibacterial agent 107 (compound 14) is a potent antibacterial agent. Antibacterial agent 107 shows potent antibacterial activity against Gram-positive bacteria, with a MIC of 1.56 μg/mL (MRSA). Antibacterial agent 107 exhibits low hemolytic activity, high membrane selectivity, and rapid bactericidal activity. Antibacterial agent 107 shows effective in vivo efficacy in the murine model of bacterial keratitis caused by Staphylococcus aureus ATCC29213 .
|
-
- HY-126735
-
|
Antibiotic
Bacterial
|
Infection
|
Saquayamycin D is an antibiotic, which can be isolated from Streptomyces nodosus culture broth. Saquayamycin D exhibits antibacterial activity against various gram-positive bacteria with MIC of 12.5-50 μg/mL. Saquayamycin D inhibits the proliferation of Doxorubicin (HY-15142)-sensitive P388/S and Doxorubicin-resistant P388/ADR with IC50 of 0.15 and 0.15 μg/mL .
|
-
- HY-13858AR
-
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
Sarecycline (hydrochloride) (Standard) is the analytical standard of Sarecycline (hydrochloride). This product is intended for research and analytical applications. Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloride has anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne .
|
-
- HY-D0215
-
Safranine T
|
Fluorescent Dye
Bacterial
|
Infection
Metabolic Disease
|
Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. Safranin can readily intercalate into biological macromolecules, including DNA and proteins. Safranin has antibacterial effects against gram-positive bacteria (S. aureus). Safranin can be used as a redox indicator in the determination of metal ion concentration .
|
-
- HY-N6687B
-
A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium
|
Oxidative Phosphorylation
Bacterial
Fungal
Apoptosis
Autophagy
|
Infection
Cancer
|
Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca 2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis .
|
-
- HY-N9481
-
-
- HY-146595
-
|
Bacterial
|
Infection
|
FtsZ-IN-1 is a potent FtsZ inhibitor with quinolinium ring. FtsZ-IN-1 has stronger antibacterial activity against Gram-positive bacteria with MICs of 0.5-8 μg/mL. FtsZ-IN-1 significantly causes cell elongation of B. subtilis by enhancing FtsZ polymerization. FtsZ-IN-1 exhibits low hemolytic toxicity and low tendency to induce agent resistance. FtsZ-IN-1 has against drug-resistant bacteria activity .
|
-
- HY-127146
-
|
Antibiotic
Bacterial
|
Infection
|
Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0.1 μM). Platensimycin targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance.
|
-
- HY-P10540
-
|
Bacterial
|
Infection
|
Pantinin-2 is a cysteine-free toxic peptide found in the emperor scorpion (paninus imperator). Pantinin-2 has high activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. Pantinin-2 also exhibits activity against Candida tropicalis and has relatively mild hemolytic activity against human erythrocytes. Pantinin-2 can be used in the development of antimicrobial drugs for drug-resistant pathogens .
|
-
- HY-16764A
-
JNJ-Q2 hydrochloride
|
Bacterial
|
Infection
Inflammation/Immunology
|
Acorafloxacin hydrochloride (JNJ-Q2 hydrochloride) is a broad-spectrum fluoroquinolone anti-bacterial drug being developed for the treatment of acute bacterial skin and skin-structure infections and community-acquired pneumonia .
Acorafloxacin hydrochloride (Avarofloxacin ) is an aminoethylidenylpiperidine fluoroquinolone that demonstrates antibacterial effect against numerous Gram-positive bacteria with a mean 0.12 mg/L MIC90 value .
Acorafloxacin hydrochloride (JNJ-Q2) has potential for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections .
|
-
- HY-B0330DS
-
|
Isotope-Labeled Compounds
Bacterial
Antibiotic
|
Infection
|
(R)-Ofloxacin-d3 is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .
|
-
- HY-B0885R
-
(±)-Econazol (Standard)
|
Fungal
Bacterial
Calcium Channel
Cytochrome P450
|
Infection
Metabolic Disease
|
Econazole (Standard) is the analytical standard of Econazole (HY-B0885). This product is intended for research and analytical applications. Econazole ((±)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage .
|
-
- HY-B0519R
-
|
Bacterial
Antibiotic
|
Infection
|
Tylosin (tartrate) (Standard) is the analytical standard of Tylosin (tartrate). This product is intended for research and analytical applications. Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-A0098
-
Tunicamycin
Maximum Cited Publications
110 Publications Verification
|
Bacterial
Fungal
Influenza Virus
Antibiotic
|
Infection
Inflammation/Immunology
Cancer
|
Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity .Tunicamycin increases exosome release in cervical cancer cells .
|
-
- HY-N0656A
-
|
mTOR
Bacterial
Autophagy
|
Infection
Inflammation/Immunology
Cancer
|
(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer and anti-inflammatory activity. (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .
|
-
- HY-P1708
-
BRN 537924; NSC 657143
|
Bacterial
|
Infection
|
Enopeptin A, originally isolated from a culture broth of Streptomyces sp. RK-1051, is a depsipeptide antibiotic that contains two unusual amino acids (N-methylalanine and 4-methylproline) and features a pentaenone side chain. It is effective against Gram-positive bacteria, including methicillin-resistant S. aureus (MIC=25 μg/mL), and Gram-negative bacteria, including mutant forms of E. coli and P. aeruginosa (MICs=200 μg/mL); however, it is not inhibitory to fungi.
|
-
- HY-121178
-
|
Bacterial
Fungal
|
Infection
|
Deoxyviolacein is a bacterial metabolite and byproduct in the biosynthesis of the bisindole alkaloid violacein (HY-119809) that has anticancer, antibacterial, and antifungal properties. It inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 μM. Deoxyviolacein (125 μg/mL) has antibacterial activity against Gram-positive bacteria, including S. aureus, B. subtilis, and B. megaterium. It also has antifungal activity against R. solani when used at a concentration of 2 mg/ml.
|
-
- HY-N6687A
-
A-23187 hemicalcium salt; Antibiotic A-23187 hemicalcium salt
|
Oxidative Phosphorylation
Bacterial
Fungal
Apoptosis
Autophagy
Antibiotic
|
Infection
Cancer
|
Calcimycin hemicalcium salt (A-23187 hemicalcium salt) is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemicalcium salt induces Ca 2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemicalcium salt inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemicalcium salt also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemicalcium salt induces apoptosis .
|
-
- HY-B0136S
-
FK-482-13C,15N2; CI-983-13C,15N2
|
Isotope-Labeled Compounds
Antibiotic
Bacterial
|
Infection
|
Cefdinir- 13C, 15N2 (FK-482- 13C, 15N2) is 13C and 15N labeled Cefdinir. Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for infections caused by several Gram-negative and Gram-positive bacteria. Cefdinir can be used for the research of common bacterial infections of the ear, sinus, throat, and skin .
|
-
- HY-N6263
-
AcEGCG; Peracetylated (-)-epigallocatechin-3-gallate
|
Bacterial
|
Infection
Cardiovascular Disease
Cancer
|
EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG). EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG Octaacetate reduces colitis-driven colon cancer in mice. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB) .
|
-
- HY-162923
-
|
Bacterial
Antibiotic
|
Infection
|
Antibacterial agent 244 is an orally active compound with broad-spectrum antibacterial activity, primarily targeting Gram-positive bacteria, with a MIC value of 1–4 μg/mL and low hemolytic toxicity (HC50 of 111.6 μg/mL). Antibacterial agent 244 disrupts bacterial transmembrane potential, increases membrane permeability, leading to leakage of cellular contents such as DNA and proteins, ultimately causing bacterial death. Antibacterial agent 244 can be used in research related to Gram-positive bacterial infections .
|
-
- HY-W016473
-
|
Bacterial
|
Infection
|
Adamantane-carboxylic acid is a compound with inhibitory activity against microorganisms. Although its specific target has not been clearly defined, it can inhibit Gram-positive bacteria and some Gram-negative bacteria. It forms a 1-monoacylglycerol derivative through a direct reaction with glycidol, and exerts its antibacterial effect by mechanisms such as altering the permeability of the bacterial cell membrane. This compound can be used in the research of antibacterial agents in the food and cosmetic industries to reduce harmful microbial flora and extend the shelf life of products .
|
-
- HY-N14722
-
|
Bacterial
|
Infection
Cancer
|
Lactonamycin had strong activity against Gram-positive bacteria including Staphylococcus, Streptococcus, Enterococcus, MRSA (MIC of 0.39-0.78 μg/mL) and VRE (MIC of 0.39-0.78 μg/mL). Lactonamycin also has inhibitory effect on L-1210, P388, S180, FS-3, Ehrlich, B16-BL5 and other tumor cell lines (IC50s of 0.06-3.3 μg/mL) .
|
-
- HY-16764
-
JNJ-Q2
|
Bacterial
Antibiotic
|
Infection
Inflammation/Immunology
|
Avarofloxacin (JNJ-Q2) is a broad-spectrum fluoroquinolone antibacterial agent being developed for the treatment of acute bacterial skin and skin-structure infections and community-acquired pneumonia with oral activity. Avarofloxacin (JNJ-Q2) is an aminoethylidenylpiperidine fluoroquinolone that demonstrates antibacterial effect against numerous Gram-positive bacteria with a mean 0.12 mg/L MIC90 value. Avarofloxacin (JNJ-Q2) has potential for treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections .
|
-
- HY-N13196
-
|
Bacterial
|
Infection
|
Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC50 values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively .
|
-
- HY-B1050R
-
|
Bacterial
Antibiotic
DNA/RNA Synthesis
Topoisomerase
|
Infection
|
Gemifloxacin (mesylate) (Standard) is the analytical standard of Gemifloxacin (mesylate). This product is intended for research and analytical applications. Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections .
|
-
- HY-B0330DR
-
Dextrofloxacin (Standard)
|
Bacterial
Antibiotic
|
Infection
|
(R)-Ofloxacin (Standard) is the analytical standard of (R)-Ofloxacin (HY-B0330D). (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .
|
-
- HY-B1158
-
|
Bacterial
Mas-related G-protein-coupled Receptor (MRGPR)
Interleukin Related
|
Infection
|
Imidazolidinyl urea is a commonly used antibacterial preservative in cosmetics and pharmaceuticals that releases formaldehyde through decomposition. Imidazolidinyl urea can also be used in the preparation of multifunctional hydrogels for the care of infectious wounds. Imidazolidinyl urea has broad-spectrum antibacterial activity, which mainly inhibits the reproduction of gram-negative bacteria and gram-positive bacteria, and restricts the growth of yeast and mold to a certain extent. Imidazolidinyl urea can induce non-histaminergic allergy by MRGPRX2 activation of mast cells .
|
-
- HY-13212R
-
cis-2-Decenoic acid (Standard)
|
Bacterial
|
Cancer
|
(Z)-2-Decenoic acid (Standard) is the analytical standard of (Z)-2-Decenoic acid. This product is intended for research and analytical applications. (Z)-2-decenoic acid (cis-2-Decenoic acid) is an unsaturated fatty acid produced by Pseudomonas aeruginosa. (Z)-2-decenoic acid induces a dispersion response in biofilms formed by a range of gram-negative bacteria, including P. aeruginosa, and by gram-positive bacteria. (Z)-2-decenoic acid inhibits biofilm development[1].
|
-
- HY-N14671
-
|
Antibiotic
Bacterial
|
Infection
|
Hedamycin is a quinone antibiotic. Hedamycin has anti-Gram-positive bacteria, negative bacterium, mycobacterium and yeast fungus activity (MIC is 0.031-3.2 μg/mL). 0.8 μg/mL of Hedamycin can inhibit Tetrahymena pyriformis. Hedamycin also can inhibit rat duodenum adenocarcinoma, rats Walker 256 tumor (50 μg/kg/day), HeLa cell (IG50 is 0.00013 μg/mL), e. coli lysogenic W1709 (λ) phage (MIC is 0.0125 μg/mL) .
|
-
- HY-N2150
-
|
HDAC
DNA Methyltransferase
DNA/RNA Synthesis
Bacterial
Aminopeptidase
Farnesyl Transferase
PPAR
Apoptosis
|
Infection
Inflammation/Immunology
Cancer
|
Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC50: 45 nM), DNA methyltransferases (IC50: 18.6 nM) and aminopeptidase N (APN) (IC50: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis .
|
-
- HY-P5601
-
|
Bacterial
Fungal
|
Infection
|
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
|
-
- HY-P10281
-
|
Bacterial
|
Infection
|
RW3 is a small cationic hexapeptide with amphiphilic properties. RW3 targets the plasma membrane of bacteria and works by inhibiting cell respiration and cell wall synthesis. RW3 shows high biological activity against gram-positive bacteria and does not show significant cytotoxic or hemolytic effects in previous studies. RW3 quickly kills 97% of the initial colony forming units (CFU) within 10 minutes at twice the minimum inhibitory concentration (MIC). RW3 can be used in antimicrobial and antifungal studies .
|
-
- HY-N0656AR
-
|
mTOR
Bacterial
Autophagy
|
Cancer
|
(+)-Usnic acid (Standard) is the analytical standard of (+)-Usnic acid. This product is intended for research and analytical applications. (+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity . (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .
|
-
- HY-122980
-
(S)-Myxochelin A
|
Lipoxygenase
|
Infection
|
Myxochelin A is a microbial metabolite that has been found in A. disciformis and has diverse biological activities. It is active against Gram-positive bacteria, including B. cereus, S. aureus, and M. luteus, but not Gram-negative bacteria or fungi in an agar diffusion assay when used at a concentration of 80 μg/disc. Myxochelin A inhibits 5-lipoxygenase (5-LO) activity with an IC50 value of 1.9 μM for the recombinant human enzyme. It is cytotoxic to 26-L5 colon cancer cells when used at a concentration of 3 μg/mL.
|
-
- HY-168258
-
|
Bacterial
|
Infection
|
Antibiofilm agent-13 (compound 14b) is a potent antibacterial agent that displays a broad-spectrum antimicrobial activity. Antibiofilm agent-13 could disintegrate the integrity of bacterial cell membranes by destroying transmembrane potential and enhancing membrane permeability, and causing the generation of intracellular ROS and the leakage of DNA and proteins, ultimately leading to bacterial death. Antibiofilm agent-13 inhibits both Gram-positive bacteria (MIC of 0.5-1 μg/mL) and Gram-negative bacteria (MIC of 1-32 μg/mL) .
|
-
- HY-N14774
-
|
Antibiotic
Bacterial
|
Infection
|
Lactoquinomycin B is a quinone antibiotic. Lactoquinomycin B has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin B inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.43, 0.21, 0.19, 0.16, 0.2 and 0.12, respectively .
|
-
- HY-12326A
-
Cyclic diadenylate disodium; Cyclic-di-AMP disodium
|
STING
Bacterial
Endogenous Metabolite
|
Inflammation/Immunology
|
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
|
-
- HY-B1924
-
Desmethyl-vancomycin hydrochloride
|
Bacterial
Antibiotic
|
Infection
|
Norvancomycin hydrochloride is a cell wall synthesis inhibitor targeting peptidoglycan precursors of Gram-positive bacteria and cannot pass the blood-brain barrier. Norvancomycin hydrochloride can competitively bind to peptidoglycan precursors, irreversibly inhibit bacterial cell wall synthesis, and exert antibacterial activity. Norvancomycin hydrochloride is mainly used in the study of Gram-positive bacterial infections, especially infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE). Norvancomycin hydrochloride can also be incorporated into the bionic calcium phosphate coating of titanium implants to enhance antibacterial activity and inhibit postoperative orthopedic infections .
|
-
- HY-N6680R
-
|
Bacterial
Antibiotic
|
Infection
|
Virginiamycin S1 (Standard) is the analytical standard of Virginiamycin S1. This product is intended for research and analytical applications. Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections .
|
-
- HY-16468
-
MSI-1256
|
Bacterial
HBV
FAK
Dengue Virus
|
Infection
Neurological Disease
Cancer
|
Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson ,s disease mouse models .
|
-
- HY-117285
-
Lactoquinomycin A; LQM-A
|
Antibiotic
Bacterial
|
Infection
Cancer
|
Lactoquinomycin A is a quinone antibiotic. Lactoquinomycin A has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.02, 0.006, 0.008, 0.033, 0.013 and 0.03, respectively .
|
-
- HY-12326B
-
Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium
|
STING
Bacterial
Endogenous Metabolite
|
Inflammation/Immunology
|
c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
|
-
- HY-P5601A
-
|
Bacterial
Fungal
|
Infection
|
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
|
-
- HY-N8256
-
Mycousunin
|
Fungal
|
Infection
|
(–)-Mycousnine is a microbial metabolite and derivative of Usnic Acid (HY-N0656) originally isolated from M. nawae that has antibacterial and antifungal activities. It is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and S. aureus (MICs=4, 8, and 4 g/ml, respectively) but not the Gram-negative bacteria E. coli, S. typhimurium, and K. pneumoniae (MICs=>128 g/ml for all).2 (–)-Mycousnine is also active against the fungi T. mentagrophytes, T. rubrum, and C. albicans (MICs=25, 25, and 100 μg/mL, respectively).
|
-
- HY-12326
-
Cyclic diadenylate; Cyclic-di-AMP
|
STING
Bacterial
Endogenous Metabolite
|
Inflammation/Immunology
|
c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .
|
-
- HY-170991
-
|
Bacterial
Reactive Oxygen Species
|
Infection
|
C12-rrw-NH2 (Compound Lip7) is an antibacterial agent against gram-positive bacteria, especially against Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). C12-rrw-NH2 induces bacterial death via depolarizing the bacterial cytoplasmic membrane, disrupting the integrity of the bacterial membrane, leading to leakage of nucleic acid and protein and promoting the generation of Reactive Oxygen Species. C12-rrw-NH2 is potential to be used for research of developing high-stability antimicrobial peptides .
|
-
- HY-B1158R
-
|
Bacterial
Mas-related G-protein-coupled Receptor (MRGPR)
Interleukin Related
|
Infection
|
Imidazolidinyl urea (Standard) is the analytical standard of Imidazolidinyl urea. This product is intended for research and analytical applications. Imidazolidinyl urea is a commonly used antibacterial preservative in cosmetics and pharmaceuticals that releases formaldehyde through decomposition. Imidazolidinyl urea can also be used in the preparation of multifunctional hydrogels for the care of infectious wounds. Imidazolidinyl urea has broad-spectrum antibacterial activity, which mainly inhibits the reproduction of gram-negative bacteria and gram-positive bacteria, and restricts the growth of yeast and mold to a certain extent. Imidazolidinyl urea can induce non-histaminergic allergy by MRGPRX2 activation of mast cells .
|
-
- HY-129900
-
|
Bacterial
Fungal
|
Infection
|
(-)-Luteoskyrin has a wide range of antibacterial activity, such as against malaria (with an IC50 of 0.51 μg/mL), tuberculosis (MIC of 6.25 μg/mL), and it also shows antibacterial effects (with MIC for Gram-positive bacteria ranging from 0.39 to 1.56 μg/mL, and for Gram-negative bacteria from 3.13 to 12.50 μg/mL), as well as antifungal activity (with MIC against plant pathogens ranging from 3.13 to 50μg/mL). (-)-Luteoskyrin exhibits cytotoxicity against NCI-H187 cells, with an IC50 range of 0.16–17.99 μg/mL .
|
-
- HY-105099
-
KRM-1648; ABI-1648
|
Antibiotic
DNA/RNA Synthesis
Bacterial
|
Infection
Inflammation/Immunology
|
Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase . Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml . Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB) .
|
-
- HY-117204
-
|
Antibiotic
|
Infection
|
AA-57 is an acidic lipophilic antibiotic isolated from the fermentation broth of Actinomycetes strain AA-57. The AA-57 strain was isolated from a soil sample collected in Koriyama City, Fukushima Prefecture, Japan. AA-57 has antibacterial properties against Gram-positive bacteria, Gram-negative bacteria, and acid-fast bacteria. AA-57 was discovered by screening actinomycete cultures for antibacterial properties. AA-57 exhibits significant antibacterial activity and has inhibitory effects against a variety of bacteria. The discovery of AA-57 provides new possibilities for antibacterial therapy.
|
-
- HY-69174
-
|
Bacterial
|
|
1-Amino-2,5-anhydro-1-deoxy-D-mannitol is a potent antibacterial compound with antibacterial activity against a variety of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). The application potential of 1-Amino-2,5-anhydro-1-deoxy-D-mannitol lies in its ability to effectively combat common drug-resistant bacterial infections. 1-Amino-2,5-anhydro-1-deoxy-D-mannitol may become an emerging antibacterial agent in clinical inhibition.
|
-
- HY-10393
-
PNU-100592
|
Bacterial
Antibiotic
|
Infection
|
Eperezolid (PNU-100592) is an orally active protein synthesis inhibitor that targets the bacterial 50S ribosomal subunit. Eperezolid competitively binds to a specific site on the ribosomal 50S subunit (overlapping with the binding sites of chloramphenicol (HY-B0239) and lincomycin (HY-117660)) to inhibit the translation initiation stage and exert antibacterial activity. Eperezolid can induce host cell autophagy to enhance the clearance of intracellular mycobacteria, and its MIC90 for Staphylococcus aureus and Enterococcus is 1-4 μg/mL. Eperezolid is mainly used for antibacterial research on infections with Gram-positive bacteria such as methicillin-resistant (HY-121544) Staphylococci and vancomycin-resistant (HY-B0671) Enterococci, as well as infections with intracellular bacteria such as Mycobacterium tuberculosis .
|
-
- HY-168729
-
|
Bacterial
|
Infection
|
Antibacterial agent 256 (Compound C09) is an inhibitor for type I signal peptidase (SPase I). Antibacterial agent 256 inhibits gram-positive bacteria, that inhibits S. aureus ATCC 29213, E. faecium QF31, E. faecalis SF23-1 and S. suis P1/7, with MIC of 1-16 μg/mL. Antibacterial agent 256 exhibits cytotoxicity in cancer cell HEp-2 and Caco-2 with CC50 of 14.65 μg/mL and 21.93 μg/mL. Antibacterial agent 256 exhibits a hemolytic activity on mouse RBCs, with an HC50 of 13.29 μg/mL. Antibacterial agent 256 ameliorates the MRSA skin infection in mouse model .
|
-
- HY-105099R
-
KRM-1648 (Standard); ABI-1648 (Standard)
|
Antibiotic
DNA/RNA Synthesis
Bacterial
|
Infection
Inflammation/Immunology
|
Rifalazil (Standard) is the analytical standard of Rifalazil. This product is intended for research and analytical applications. Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase[1]. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml[3]. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB)[2].
|
-
- HY-168204
-
|
Bacterial
Fungal
|
Infection
|
3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid (compound J1) is a potent antimicrobial agent. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid shows anti-gram-positive bacteria and fungi activity. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic acid can be used as antibiotic adjuvants. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic disrupts the bacterial cell membrane, inserts into the DNA, and binds to DNA gyrase. 3-Acetyl-28-N–(3–guanidinobutoxy)-oleanolic reduces microbial count in a mouse MRSA skin infection model and accelerates wound healing .
|
-
Cat. No. |
Product Name |
Type |
-
- HY-D0215
-
Safranine T
|
Dyes
|
Safranin (Safranin T) is an important and classical phenazinium dye. Safranin has been extensively used in the academic field as a spectroscopic probe and indicator. Safranin possesses a planar structure and cationic charge. Safranin can readily intercalate into biological macromolecules, including DNA and proteins. Safranin has antibacterial effects against gram-positive bacteria (S. aureus). Safranin can be used as a redox indicator in the determination of metal ion concentration .
|
Cat. No. |
Product Name |
Type |
-
- HY-P3466
-
|
Biochemical Assay Reagents
|
Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans .
|
-
- HY-W016473
-
|
Biochemical Assay Reagents
|
Adamantane-carboxylic acid is a compound with inhibitory activity against microorganisms. Although its specific target has not been clearly defined, it can inhibit Gram-positive bacteria and some Gram-negative bacteria. It forms a 1-monoacylglycerol derivative through a direct reaction with glycidol, and exerts its antibacterial effect by mechanisms such as altering the permeability of the bacterial cell membrane. This compound can be used in the research of antibacterial agents in the food and cosmetic industries to reduce harmful microbial flora and extend the shelf life of products .
|
-
- HY-B2237A
-
|
Biochemical Assay Reagents
|
Lysozyme chloride is a bactericidal enzyme, and it lyses gram-positive bacteria. Lysozyme chloride can also be used for the research of HIV infection and pulmonary emphysema .
|
-
- HY-D0008
-
|
Biochemical Assay Reagents
|
Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal parasites and fungus. Brilliant green is effective against Gram-positive bacteria .
|
-
- HY-D0008R
-
|
Biochemical Assay Reagents
|
Brilliant green (Standard) is the analytical standard of Brilliant green. This product is intended for research and analytical applications. Brilliant green is a cationic dye used to color silk and wool. Brilliant green inhibits propagation of mold, intestinal parasites and fungus. Brilliant green is effective against Gram-positive bacteria .
|
-
- HY-69174
-
|
Microbial Culture
|
1-Amino-2,5-anhydro-1-deoxy-D-mannitol is a potent antibacterial compound with antibacterial activity against a variety of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). The application potential of 1-Amino-2,5-anhydro-1-deoxy-D-mannitol lies in its ability to effectively combat common drug-resistant bacterial infections. 1-Amino-2,5-anhydro-1-deoxy-D-mannitol may become an emerging antibacterial agent in clinical inhibition.
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-129034
-
|
Bacterial
Antibiotic
|
Infection
|
Ramoplanin is a broad-spectrum lipoglycodepsipeptide antibiotic derived from the Actinoplanes spp with with activity against gram-positive bacteria .
|
-
- HY-P3466
-
-
- HY-P2047
-
Antibiotic FR-900201
|
Antibiotic
Bacterial
|
Infection
|
Lavendomycin is a peptide antibiotic from Streptomyces. Lavendomycin inhibits Gram-positive bacteria .
|
-
- HY-P2599
-
-
- HY-P5628
-
|
Bacterial
|
Infection
|
Termicin is an antimicrobial peptide from Pseudacanthotermes spiniger. Termicin has anti-gram-positive bacteria, filamentous fungi and yeast activity .
|
-
- HY-P1699
-
-
- HY-P5592
-
|
Bacterial
|
Infection
|
Temporin B is an antimicrobial peptide against Gram-positive bacteria. Temporin B is less active against Gram-negative bacteria .
|
-
- HY-P5592A
-
|
Bacterial
|
Infection
|
Temporin B acetate is an antimicrobial peptide against Gram-positive bacteria. Temporin B acetate is less active against Gram-negative bacteria .
|
-
- HY-P2070
-
|
Bacterial
|
Infection
|
Aspartocin D is an analogue of Amphomycin (HY-P3078). Aspartocin D shows antimicrobial activities against Gram-positive bacteria .
|
-
- HY-P1720
-
|
Antibiotic
Bacterial
|
Infection
|
Telomycin is a calcium-dependent antibiotic, which can be produced by Streptomyces. Telomycin inhibits gram-positive bacteria, including multidrug-resistant (MDR) pathogens .
|
-
- HY-P1607
-
-
- HY-P5630
-
|
Bacterial
|
Infection
|
Aeschna defensing is an antimicrobial peptide derived from hemolymph of dragonfly aquatic larvae. Aeschna defensing has strong activity against gram-positive bacteria .
|
-
- HY-P1926
-
|
Antibiotic
Bacterial
|
Infection
|
A-54556A (ADEP 1) is an acyldepsipeptide (ADEP) antibiotic. A-54556A shows antibacterial activity against a broad range of Gram-positive bacteria .
|
-
- HY-P2331
-
Antibiotic A 3802-IV-3; Gardimycin
|
Antibiotic
|
Infection
|
Actagardin is a tetracyclic lantibiotic produced by several species of Actinoplanes. It is composed of macrocyclic rings formed by thioether bridges. Actagardin preferably targets Gram-positive bacteria, inhibiting the synthesis of peptidoglycan.
|
-
- HY-106882
-
MDL 62879
|
Bacterial
Antibiotic
|
Infection
|
GE 2270A (MDL 62879) is an antibiotic. GE 2270A inhibits gram-positive bacteria and anaerobes by inhibiting protein synthesis. GE 2270A can be used for the research of infection .
|
-
- HY-P3916
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
GVLSNVIGYLKKLGTGALNAVLKQ is an antimicrobial peptide with 24-amino acid. GVLSNVIGYLKKLGTGALNAVLKQ can potentially form α-helix. GVLSNVIGYLKKLGTGALNAVLKQ (PGQ) has activity against Gram-negative, Gram-positive bacteria and the yeast Candida albicans .
|
-
- HY-P0269
-
Magainin I
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .
|
-
- HY-P3365
-
|
Bacterial
|
Inflammation/Immunology
Cancer
|
Cecropin D is an antimicrobial peptide with a MIC of 4.55 μg/mL. Cecropin D is effective against both Gram-negative and Gram-positive bacteria. Cecropin D has antiviral, antifungal, antitumor, and immunomodulatory .
|
-
- HY-P5561
-
|
Antibiotic
Bacterial
|
Infection
|
Aurein 2.2 is a major component of the skin secretion of L.aurea. Aurein 2.2 is an antibiotic with broad-spectrum antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and S. epidermidis .
|
-
- HY-P5708
-
Dermaseptin b2
|
Antibiotic
Fungal
Bacterial
|
Infection
|
Adenoregulin (Dermaseptin b2) is an antimicrobial peptide antibiotic. Adenoregulin is active against Gram-negative and Gram-positive bacteria, yeast and fungi. Adenoregulin also enhances the binding of agonists to the A1 adenosine receptor .
|
-
- HY-P10352
-
|
Bacterial
|
Infection
|
Pediocin PA-1 is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 can be used as a food biopreservative .
|
-
- HY-P10210
-
|
Antibiotic
Bacterial
|
Infection
|
Paenilagicin is a Gram-positive active antibiotic with a unique diphosphorylated prenyl binding mechanism that does not induce drug resistance. Paenilagicin exhibits a MIC value of 2 μg/mL against multidrug-resistant Gram-positive bacteria .
|
-
- HY-P10219
-
|
Bacterial
|
Infection
Inflammation/Immunology
|
Brevicidine analog 22 (22) exerts broad spectrum antimicrobial activity and excellent stability (t1/2 = 40.98 h), with MICs of 2-16 μM for gram-negative and gram-positive bacteria .
|
-
- HY-P2020
-
|
Bacterial
|
Infection
|
Berninamycin A is a cyclic thiopeptide antibiotic first isolated from S. bernensis. It inhibits protein biosynthesis in Gram positive bacteria through binding with ribosomal subunits. Cyclic thiopeptide antibiotics, including berninamycin A, induce the transcriptional activator TipA in Streptomyces.
|
-
- HY-P10352A
-
|
Bacterial
|
Infection
|
Pediocin PA-1 TFA is a broad-spectrum lactic acid bacterial bacteriocin that inhibits the activity of foodborne pathogens such as Listeria monocytogenes and Gram-positive bacteria. Pediocin PA-1 TFA can be used as a food biopreservative .
|
-
- HY-P0269A
-
Magainin I TFA
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Magainin 1 TFA (Magainin I TFA) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 TFA exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .
|
-
- HY-P1631
-
|
Bacterial
|
Infection
|
Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against Gram-negative and Gram-positive bacteria. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges .
|
-
- HY-W587753
-
|
Antibiotic
Bacterial
|
Infection
|
Bacitracin A is an antibiotic, which exhibits antibacterial activity against gram-positive bacteria. Bacitracin A forms complex with long-chain polyisoprenyl pyrophosphates in presence of metal ions, dephosphorylates the lipid carrier intermediate Css-bactoprenyl pyrophosphate, inhibits thus the bacterial cell wall biosynthesis .
|
-
- HY-W748000
-
PM181104; Baringolin
|
Antibiotic
Bacterial
|
Infection
|
Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against Gram-positive bacteria, but no activity against fungi and Gram-negative bacteria .
|
-
- HY-P10695
-
|
Bacterial
Antibiotic
|
Infection
|
Bac8c is an antimicrobial peptide with strong antibacterial activity against Gram-negative and Gram-positive bacteria. The MIC of Bac8c against S. aureus, MRSA, S. epidermidis, E. coli, and P. aeruginosa are 2, 8, 4, 4, and 4 μg/mL, respectively .
|
-
- HY-N6708
-
|
Antibiotic
Bacterial
|
Infection
|
Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes .
|
-
- HY-P5563
-
|
Bacterial
|
Infection
|
PP113 is an antimicrobial peptide is active against Gram-negative and Gram-positive bacteria, E.coli (MIC: 73.3 uM), B. subtilis (MIC: 23.3 uM), S. aureus (MIC: 13 uM), S. lutea (MIC: 16.7 uM), and B. pumilu (MIC: 23.3 uM) .
|
-
- HY-P5560
-
|
Bacterial
|
Infection
|
PP13 is an antimicrobial peptide, and is active against Gram-negative and Gram-positive bacteria E.coli (MIC: 16.7 uM), B. subtilis (MIC: 13.3 uM), S. aureus (MIC: 23.3 uM), S. lutea (MIC: 8.0 uM), and B. pumilu (MIC: 9.0 uM) .
|
-
- HY-P10539
-
|
Bacterial
|
Infection
|
Hp1404 is a novel cationic antimicrobial peptide. Hp1404 has specific inhibitory activity against Gram-positive bacteria, including Staphylococcus aureus (MRSA) resistant to Laburnetin (HY-N7382). Hp1404 has antimicrobial activity, low toxicity, and is not prone to drug resistance, and can be used in the research of antimicrobial agents .
|
-
- HY-P1629
-
|
Bacterial
Fungal
Antibiotic
|
Infection
|
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .
|
-
- HY-P0270
-
Magainin II
|
Bacterial
Antibiotic
Fungal
|
Infection
|
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .
|
-
- HY-P10508
-
|
Bacterial
Apoptosis
|
Infection
Cancer
|
Pantinin-1 is an antimicrobial peptide found in the venom of the Pandinus imperator scorpion. Pantinin-1 has potent antimicrobial activity against Gram-positive bacteria and fungi, weak antimicrobial activity against Gram-negative bacteria, and very low hemolytic activity against human erythrocytes. Pantinin-1 also has anticancer activity and can induce apoptosis in tumor cells .
|
-
- HY-P10228
-
|
Fungal
Bacterial
|
Infection
|
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na +/K +) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .
|
-
- HY-P10515
-
|
Bacterial
Fungal
|
Infection
Cancer
|
AcrAP2 is an antimicrobial peptide present in the venom of the Arabian scorpion (Androctonus crassicauda). AcrAP2 is inhibitory against Gram-positive bacteria and yeast but is essentially inactive against Gram-negative bacteria. A cation-enhanced AcrAP2 analog (AcrAP2a) exhibits significant antiproliferative effects at low concentrations against certain human cancer cell lines. AcrAP2 can be used in antibacterial and anti-tumor research .
|
-
- HY-P10540
-
|
Bacterial
|
Infection
|
Pantinin-2 is a cysteine-free toxic peptide found in the emperor scorpion (paninus imperator). Pantinin-2 has high activity against Gram-positive bacteria but weak activity against Gram-negative bacteria. Pantinin-2 also exhibits activity against Candida tropicalis and has relatively mild hemolytic activity against human erythrocytes. Pantinin-2 can be used in the development of antimicrobial drugs for drug-resistant pathogens .
|
-
- HY-N11615R
-
|
Peptides
|
Others
|
Tylosin (tartrate) (Standard) is the analytical standard of Tylosin (tartrate). This product is intended for research and analytical applications. Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-P5601
-
|
Bacterial
Fungal
|
Infection
|
Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
|
-
- HY-P10281
-
|
Bacterial
|
Infection
|
RW3 is a small cationic hexapeptide with amphiphilic properties. RW3 targets the plasma membrane of bacteria and works by inhibiting cell respiration and cell wall synthesis. RW3 shows high biological activity against gram-positive bacteria and does not show significant cytotoxic or hemolytic effects in previous studies. RW3 quickly kills 97% of the initial colony forming units (CFU) within 10 minutes at twice the minimum inhibitory concentration (MIC). RW3 can be used in antimicrobial and antifungal studies .
|
-
- HY-P5601A
-
|
Bacterial
Fungal
|
Infection
|
Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
|
-
- HY-K1050
-
1 Publications Verification
|
MCE Gentamicin, Sterile acts by binding to the 30S subunit of the bacterial ribosome leading to inhibition of protein synthesis and death in susceptible bacteria, mainly for gram-negative and gram-positive bacteria.
|
-
- HY-K1008
-
1 Publications Verification
|
MCE Gentamicin-Amphotericin B (500×), sterile is used to prevent contamination of cell culture due to their effective combined action against gram-positive bacteria, gram-negative bacteria, fungi and yeasts.
|
-
- HY-K1057
-
Maximum Cited Publications
28 Publications Verification
|
Puromycin is an aminonucleoside antibiotic produced by Streptomyces alboniger. It inhibits protein synthesis by disrupting peptide transfer on ribosomes, causing premature chain termination during translation. It can kill most gram-positive bacteria and various animal or insect cells.
|
-
- HY-K1097
-
|
MCE Gram Stain Kit can be used to differentiate between Gram-negative and Gram-positive bacteria.
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
- HY-N14477
-
-
- HY-N14826
-
-
- HY-N14755
-
-
- HY-N14372
-
-
- HY-126577
-
-
- HY-N6728
-
-
- HY-125395
-
-
- HY-123190
-
-
- HY-105350
-
-
- HY-W011916
-
-
- HY-N14986
-
-
- HY-N14445
-
-
- HY-N14025
-
-
- HY-N14478
-
-
- HY-B1150
-
-
- HY-N14784
-
-
- HY-N12681
-
-
- HY-124111
-
-
- HY-N14246
-
-
- HY-N14469
-
-
- HY-W748030
-
-
- HY-N15104
-
-
- HY-N14750
-
-
- HY-129280
-
-
- HY-125656
-
-
- HY-N14719
-
-
- HY-N14128
-
-
- HY-125618
-
-
- HY-N14987
-
-
- HY-N14492
-
-
- HY-N14803
-
-
- HY-N12682
-
-
- HY-126469
-
-
- HY-N14543
-
-
- HY-N14714
-
-
- HY-N14759
-
-
- HY-N14261
-
-
- HY-N13995
-
-
- HY-115367
-
-
- HY-N14745
-
-
- HY-130471
-
-
- HY-121148
-
-
- HY-N14653
-
-
- HY-N12679
-
-
- HY-N14125
-
-
- HY-N12680
-
-
- HY-N14174
-
-
- HY-N14998
-
-
- HY-N12676
-
-
- HY-N12675
-
-
- HY-N14610
-
-
- HY-N14655
-
-
- HY-N14613
-
-
- HY-N14768
-
-
- HY-N15075
-
-
- HY-N15082
-
-
- HY-N14680
-
-
- HY-N13892
-
-
- HY-N13884
-
-
- HY-N14787
-
-
- HY-126151
-
-
- HY-N14674
-
-
- HY-N14167
-
-
- HY-125419
-
-
- HY-N14338
-
-
- HY-123321
-
-
- HY-129034
-
-
- HY-129291
-
-
- HY-N15032
-
-
- HY-N14327
-
-
- HY-N14654
-
-
- HY-N14695
-
-
- HY-123716
-
-
- HY-N14488
-
-
- HY-B1222A
-
-
- HY-N14829
-
-
- HY-B1222
-
-
- HY-118553
-
-
- HY-N14736
-
-
- HY-N14209
-
-
- HY-N14301
-
-
- HY-N13147
-
-
- HY-N13920
-
-
- HY-N14487
-
-
- HY-N14210
-
-
- HY-N14541
-
-
- HY-N14538
-
-
- HY-N14587
-
-
- HY-N14656
-
-
- HY-N14345
-
-
- HY-120383
-
-
- HY-N14380
-
-
- HY-N14178
-
-
- HY-N14513
-
-
- HY-N10081
-
-
- HY-N11408
-
-
- HY-N14396
-
-
- HY-N14840
-
-
- HY-N13885
-
-
- HY-N14849
-
-
- HY-N15038
-
-
- HY-N14833
-
-
- HY-N14119
-
-
- HY-N15106
-
-
- HY-127014
-
-
- HY-N14118
-
-
- HY-N13941
-
-
- HY-B1150R
-
-
- HY-N14673
-
-
- HY-126660
-
-
- HY-133704
-
-
- HY-118021
-
-
- HY-125608
-
-
- HY-N14572
-
-
- HY-W780198
-
-
- HY-N13881
-
-
- HY-N13877
-
-
- HY-N14623
-
-
- HY-N13962
-
-
- HY-N15184
-
-
- HY-116271
-
-
- HY-N12421
-
-
- HY-N14847
-
-
- HY-W726164
-
-
- HY-N14532
-
-
- HY-N14133
-
-
- HY-N5187
-
-
- HY-N14008
-
-
- HY-N14475
-
-
- HY-N15095
-
-
- HY-111264
-
-
- HY-N13981
-
-
- HY-N14528
-
-
- HY-N14657
-
-
- HY-E70250
-
-
- HY-N14106
-
-
- HY-N14675
-
-
- HY-N14706
-
-
- HY-N7151
-
-
- HY-N14551
-
-
- HY-N14707
-
-
- HY-116168
-
-
- HY-N14710
-
-
- HY-N14830
-
-
- HY-N14088
-
-
- HY-N6738
-
-
- HY-100528
-
-
- HY-N1307
-
-
- HY-N14693
-
-
- HY-N13963
-
-
- HY-117660R
-
-
- HY-N14529
-
-
- HY-119968
-
-
- HY-W782391R
-
-
- HY-N14677
-
-
- HY-N14660
-
-
- HY-N11535
-
-
- HY-N14091
-
-
- HY-N14202
-
-
- HY-N14090
-
-
- HY-N14089
-
-
- HY-N14709
-
-
- HY-N14708
-
-
- HY-N13292
-
-
- HY-N10229
-
-
- HY-N14516
-
-
- HY-N13910
-
-
- HY-N14694
-
-
- HY-N14203
-
-
- HY-N14177
-
-
- HY-N14692
-
-
- HY-N14201
-
-
- HY-N5191
-
-
- HY-N14176
-
-
- HY-N14515
-
-
- HY-N14398
-
-
- HY-N13949
-
-
- HY-N14200
-
-
- HY-N15334
-
-
- HY-N13894
-
-
- HY-N14499
-
-
- HY-100528A
-
-
- HY-118992
-
-
- HY-N14617
-
-
- HY-N9720
-
-
- HY-N14916
-
-
- HY-125652
-
-
- HY-N14571
-
-
- HY-114798
-
-
- HY-125104
-
-
- HY-N13895
-
-
- HY-N14010
-
-
- HY-N15029
-
-
- HY-129329
-
-
- HY-P0269
-
-
- HY-B1222AR
-
-
- HY-N14619
-
-
- HY-125117
-
-
- HY-123436
-
-
- HY-B2237
-
-
- HY-P5708
-
-
- HY-N14365
-
-
- HY-N14095
-
-
- HY-108191
-
-
- HY-N14652
-
-
- HY-N6748
-
-
- HY-N14107
-
-
- HY-P0269A
-
-
- HY-N14496
-
-
- HY-N14608
-
-
- HY-N14837
-
-
- HY-N15028
-
-
- HY-N13990
-
-
- HY-N14110
-
-
- HY-N13991
-
-
- HY-119604
-
-
- HY-N15019
-
-
- HY-N14171
-
-
- HY-119188
-
-
- HY-N15420
-
-
- HY-N14028
-
-
- HY-B1222R
-
-
- HY-127155
-
-
- HY-126662
-
-
- HY-N14747
-
-
- HY-19829
-
-
- HY-N15063
-
-
- HY-N13891
-
-
- HY-W748000
-
PM181104; Baringolin
|
Microorganisms
Source classification
|
Antibiotic
Bacterial
|
Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against Gram-positive bacteria, but no activity against fungi and Gram-negative bacteria .
|
-
- HY-N14172
-
-
- HY-100528R
-
-
- HY-106338
-
-
- HY-126695
-
-
- HY-123325
-
-
- HY-N14776
-
-
- HY-N14029
-
-
- HY-N14030
-
-
- HY-N15337
-
-
- HY-125721
-
-
- HY-N1672
-
-
- HY-N14689
-
-
- HY-N14685
-
-
- HY-N14959
-
-
- HY-129252
-
-
- HY-N1416
-
-
- HY-N12178
-
-
- HY-N14887
-
-
- HY-B0275
-
-
- HY-N7188
-
-
- HY-N11137
-
-
- HY-B0275A
-
-
- HY-N6708
-
-
- HY-N1671
-
-
- HY-N12496
-
-
- HY-N14530
-
-
- HY-N15391
-
-
- HY-N14144
-
-
- HY-111333
-
Dioxapyrrolomycin; LL-F42248α; AL-R2081
|
Structural Classification
Microorganisms
Antibiotics
Source classification
|
Bacterial
|
Pyrroxamycin is a novel antibiotic produced by Streptomyces, whose chemical structure was determined by chemical properties and X-ray crystallography and 13C NMR spectroscopy analysis. It is active against Gram-positive bacteria and dermatophytes. In this paper, the authors discuss the taxonomy, fermentation, isolation, physicochemical properties, chemical structure, and biological activity of the strain producing Pyrroxamycin.
|
-
- HY-B0275C
-
-
- HY-A0097
-
-
- HY-119789
-
-
- HY-A0097A
-
-
- HY-126858
-
-
- HY-N10755A
-
-
- HY-N12096
-
-
- HY-B0275B
-
-
- HY-125365
-
-
- HY-113829
-
|
Structural Classification
Natural Products
Animals
Source classification
|
Antibiotic
Bacterial
|
Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs . Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury .
|
-
- HY-B0519A
-
-
- HY-117840
-
-
- HY-N14415
-
-
- HY-N14548
-
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Antibiotic
Bacterial
|
Cryptosporiopsin can be isolated from the strain of Cryptosporiopsis sp. and Sporormia affinis. Cryptosporiopsin has antibacterial activity to many kinds of basidiomycetes, algal fungi, ascomycetes and hemiplegia fungi that cause wood rot, and can inhibit spore germination of Phytophthora potatoes. Cryptosporiopsin also has certain activity against gram-positive bacteria and negative bacteria .
|
-
- HY-B1729R
-
|
Microorganisms
Source classification
|
Oxidative Phosphorylation
Bacterial
Fungal
|
Phenoxyethanol (Standard) is the analytical standard of Phenoxyethanol. This product is intended for research and analytical applications. Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al .
|
-
- HY-N14111
-
-
- HY-N8316
-
-
- HY-B0519B
-
-
- HY-B0519
-
-
- HY-123121
-
-
- HY-13212
-
-
- HY-N14112
-
-
- HY-125650
-
-
- HY-137323
-
-
- HY-130173
-
-
- HY-N7165
-
-
- HY-N14344
-
-
- HY-B0275R
-
-
- HY-N14342
-
-
- HY-105751
-
-
- HY-N14343
-
-
- HY-N1416R
-
-
- HY-A0279
-
-
- HY-B0275AR
-
-
- HY-117818
-
-
- HY-19827
-
-
- HY-P0270
-
-
- HY-N14056
-
-
- HY-N14163
-
-
- HY-105463
-
|
Quinones
Structural Classification
Microorganisms
Anthraquinones
Source classification
|
Antibiotic
Bacterial
|
Saptomycin D is an antibiotic with antitumor activity isolated from the Streptomyces sp. HP530 strain. Saptomycin D exhibits potent inhibitory effects against Gram-positive bacteria, while demonstrating weaker inhibitory activities against certain Gram-negative bacteria and yeasts. Saptomycin D also displays remarkable antitumor properties. Saptomycin D is applicable in research within the field of oncology .
|
-
- HY-N6687
-
-
- HY-B0275BR
-
-
- HY-121348
-
U-47929
|
Structural Classification
Microorganisms
Antibiotics
Source classification
Other Antibiotics
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Ficellomycin is a nitrogen-containing bicyclic antibiotic with strong activity against Gram-positive bacteria, including multidrug-resistant strains of Staphylococcus aureus. Ficellomycin works by inducing the formation of defective 34S DNA fragments, which interfere with the semi-conservative DNA replication process. These fragments lack the ability to integrate into larger DNA segments and eventually form a complete bacterial chromosome. Ficellomycin can be used in research for various bacterial diseases .
|
-
- HY-112661
-
-
- HY-B0519AR
-
-
- HY-B0519BR
-
-
- HY-125365R
-
-
- HY-N6680
-
-
- HY-N9481
-
-
- HY-B0519R
-
-
- HY-A0098
-
-
- HY-N11615R
-
|
Structural Classification
Alkaloids
Microorganisms
Other Alkaloids
Source classification
|
Others
|
Tylosin (tartrate) (Standard) is the analytical standard of Tylosin (tartrate). This product is intended for research and analytical applications. Tylosin tartrate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin tartrate is widely used as a feed additive for promoting animal growth. Tylosin tartrate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle .
|
-
- HY-N0656A
-
|
Structural Classification
other families
Classification of Application Fields
Ketones, Aldehydes, Acids
Plants
Lichen
Disease Research Fields
Cancer
|
mTOR
Bacterial
Autophagy
|
(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer and anti-inflammatory activity. (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .
|
-
- HY-N6687A
-
-
- HY-N14722
-
-
- HY-N13196
-
|
Structural Classification
Microorganisms
Antibiotics
Source classification
|
Bacterial
|
Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC50 values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively .
|
-
- HY-13212R
-
cis-2-Decenoic acid (Standard)
|
Structural Classification
Microorganisms
Ketones, Aldehydes, Acids
Source classification
|
Bacterial
|
(Z)-2-Decenoic acid (Standard) is the analytical standard of (Z)-2-Decenoic acid. This product is intended for research and analytical applications. (Z)-2-decenoic acid (cis-2-Decenoic acid) is an unsaturated fatty acid produced by Pseudomonas aeruginosa. (Z)-2-decenoic acid induces a dispersion response in biofilms formed by a range of gram-negative bacteria, including P. aeruginosa, and by gram-positive bacteria. (Z)-2-decenoic acid inhibits biofilm development[1].
|
-
- HY-N14671
-
|
Quinones
Structural Classification
Microorganisms
Source classification
Benzene Quinones
|
Antibiotic
Bacterial
|
Hedamycin is a quinone antibiotic. Hedamycin has anti-Gram-positive bacteria, negative bacterium, mycobacterium and yeast fungus activity (MIC is 0.031-3.2 μg/mL). 0.8 μg/mL of Hedamycin can inhibit Tetrahymena pyriformis. Hedamycin also can inhibit rat duodenum adenocarcinoma, rats Walker 256 tumor (50 μg/kg/day), HeLa cell (IG50 is 0.00013 μg/mL), e. coli lysogenic W1709 (λ) phage (MIC is 0.0125 μg/mL) .
|
-
- HY-N2150
-
-
- HY-N0656AR
-
|
Structural Classification
other families
Ketones, Aldehydes, Acids
Plants
Lichen
|
mTOR
Bacterial
Autophagy
|
(+)-Usnic acid (Standard) is the analytical standard of (+)-Usnic acid. This product is intended for research and analytical applications. (+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity . (+)-Usnic acid possesses antimicrobial activity against a number of planktonic gram-positive bacteria, including Staphylococcus aureus, Enterococcus faecalis, and Enterococcus faecium .
|
-
- HY-N14774
-
|
Structural Classification
Microorganisms
Antibiotics
Source classification
Other Antibiotics
|
Antibiotic
Bacterial
|
Lactoquinomycin B is a quinone antibiotic. Lactoquinomycin B has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin B inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.43, 0.21, 0.19, 0.16, 0.2 and 0.12, respectively .
|
-
- HY-12326A
-
-
- HY-N6680R
-
|
Structural Classification
Microorganisms
Macrolide Antibiotics
Antibiotics
Source classification
Antibacterial
Disease Research
|
Bacterial
Antibiotic
|
Virginiamycin S1 (Standard) is the analytical standard of Virginiamycin S1. This product is intended for research and analytical applications. Virginiamycin S1 is a cyclic hexadepsipeptide antibiotic, inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. Virginiamycin S1 belongs to the type B compounds in the streptogramin family and is produced by Streptomyces virginiae, shows a strong bactericidal activity against a wide range of Gram-positive bacteria. Virginiamycin S1 together with virginiamycin M1 is more effective in treat multidrug-resistant bacterial infections .
|
-
- HY-16468
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- HY-117285
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Lactoquinomycin A; LQM-A
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Structural Classification
Microorganisms
Antibiotics
Source classification
Other Antibiotics
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Antibiotic
Bacterial
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Lactoquinomycin A is a quinone antibiotic. Lactoquinomycin A has the activity of anti-Gram-positive bacteria and some Gram-negative bacteria, but the effect of anti-Gram-negative bacteria is weak and has no effect on fungi. Lactoquinomycin A inhibits a variety of cell lines including lymphoma L5178Y progenitor, Adriamycin resistant, Bleomycin-resistant, human leukemia K562, mouse leukemia L-1210 and mouse leukemia P 388 with ID50 (μg/mL) of 0.02, 0.006, 0.008, 0.033, 0.013 and 0.03, respectively .
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- HY-12326B
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- HY-12326
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- HY-117204
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Structural Classification
Natural Products
Microorganisms
Source classification
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Antibiotic
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AA-57 is an acidic lipophilic antibiotic isolated from the fermentation broth of Actinomycetes strain AA-57. The AA-57 strain was isolated from a soil sample collected in Koriyama City, Fukushima Prefecture, Japan. AA-57 has antibacterial properties against Gram-positive bacteria, Gram-negative bacteria, and acid-fast bacteria. AA-57 was discovered by screening actinomycete cultures for antibacterial properties. AA-57 exhibits significant antibacterial activity and has inhibitory effects against a variety of bacteria. The discovery of AA-57 provides new possibilities for antibacterial therapy.
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Cat. No. |
Product Name |
Chemical Structure |
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- HY-B1252AS
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Cefalonium-d4 (hydrate) is the deuterium labeled Cefalonium (hydrate)(HY-B1252A).Cefalonium hydrate is the first-generation β-lactam cephalosporin antibiotic that is widely used to research bovine mastitis caused by Gram-positive bacteria including staphylococci .
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- HY-W011117S1
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Danofloxacin-d3-1 is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase .
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- HY-19581S
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Baquiloprim-d6 is deuterium labeled Baquiloprim. Baquiloprim, an antibiotic, is a selective inhibitor of bacterial dihydrofolate reductases. Baquiloprim possesses in vitro bacteriostatic activity against both Gram-negative and Gram-positive bacteria[1][2].
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- HY-B1282S
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Sulfaquinoxaline-d4 is the deuterium labeled Sulfaquinoxaline. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections[1][2].
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- HY-B1459AS
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Dicloxacillin- 13C4 is the 13C labeled Dicloxacillin[1]. Dicloxacillin is a β-lactam antibiotic of the penicillin family. Dicloxacillin against Gram-positive bacteria. Dicloxacillin is active against β-lactamase-producing organisms such as Staphylococcus aureus[2].
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- HY-Y0264S
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4-Hydroxybenzoic acid- 13C6 is the 13C labeled isotope of 4-Hydroxybenzoic acid- 13C6.4-Hydroxybenzoic acid is a phenolic derivative of benzoic acid, which can inhibit most Gram-positive bacteria and some Gram-negative bacteria with an IC50 value of 160 μg/mL.
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- HY-W011117S
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Danofloxacin-d3 is deuterium labeled Danofloxacin. Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase[1][2].
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- HY-17586AS
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Dalbavancin-d6 is the deuterium labeled Dalbavancin[1]. Dalbavancin (MDL-63397) is a semisynthetic lipoglycopeptide antibiotic with potent bactericidal activity against Gram-positive bacteria. Dalbavancin inhibits Staphylococcus aureus and Bacillus anthracis with MIC90s of 0.06 μg/mL and 0.25 μg/mL, respectively[2][3].
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- HY-B1729S1
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Phenoxyethanol-d4 is the deuterium labeled Phenoxyethanol[1]. Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al[2].
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- HY-B1729S
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Phenoxyethanol-d2 is the deuterium labeled Phenoxyethanol[1]. Phenoxyethanol has a broad spectrum of antimicrobial activity against various gram-negative and gram-positive bacteria. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al[2].
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- HY-B1002S
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Oxolinic acid-d5 is the deuterium labeled Oxolinic acid. Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].
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- HY-B0275S
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Oxytetracycline-d6 is deuterium labeled Oxytetracycline. Oxytetracycline is an antibiotic belonging to the tetracycline class. Oxytetracycline potent inhibits Gram-negative and Gram-positive bacteria. Oxytetracycline is a protein synthesis inhibitor and prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity .
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- HY-10394S1
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PNU-100766-d8 is deuterated labeled Linezolid (HY-10394). Linezolid (PNU-100766) is the first member of the class of oxazolidinone synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. Linezolid is used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics .
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- HY-B0519AS
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Tylosin-d3 is the deuterium labeled Tylosin. Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle[1][2][3].
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- HY-B0330DS
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(R)-Ofloxacin-d3 is the deuterium labeled (R)-Ofloxacin. (R)-Ofloxacin is the dextrorotatory enantiomer of Ofloxacin (HY-B0125) and is an orally effective fluoroquinolone antibiotic. (R)-Ofloxacin can inhibit the activity of bacterial DNA topoisomerase II, interfere with bacterial DNA replication and repair, and exert a bactericidal effect. (R)-Ofloxacin has a broad-spectrum antibacterial activity and has inhibitory effects on both Gram-negative and Gram-positive bacteria .
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- HY-B0136S
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Cefdinir- 13C, 15N2 (FK-482- 13C, 15N2) is 13C and 15N labeled Cefdinir. Cefdinir (FK-482) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, which is proved to be effective for infections caused by several Gram-negative and Gram-positive bacteria. Cefdinir can be used for the research of common bacterial infections of the ear, sinus, throat, and skin .
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